# annotation

uniprotID: A0A075B6T7
geneSymbol: TRAV6
name: T cell receptor alpha variable 6
length: 132
go: ENSG00000211780;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MAFWLRSLGLHFRPHLGRRMESFLGGVLLILWLQVDWVKSQKIEQNSEALNIQEGKTATLTCNYTNYSPAYLQWYRQDPGRGPVFLLLIRENEKEKRKERLKVTFDTTLKQSLFHITASQPADSATYLCALD


uniprotID: A0A0K0K1G8
geneSymbol: TRBV10-2
name: T cell receptor beta variable 10-2
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLFFYVALCLLWAGHRDAGITQSPRYKITETGRQVTLMCHQTWSHSYMFWYRQDLGHGLRLIYYSAAADITDKGEVPDGYVVSRSKTENFPLTLESATRSQTSVYFCASSE


uniprotID: A0A0K0K1G6
geneSymbol: TRBV10-3
name: T cell receptor beta variable 10-3
length: 114
go: ENSG00000275791;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLFFYVALCLLWTGHMDAGITQSPRHKVTETGTPVTLRCHQTENHRYMYWYRQDPGHGLRLIHYSYGVKDTDKGEVSDGYSVSRSKTEDFLLTLESATSSQTSVYFCAISE


uniprotID: A0A0K0K1C0
geneSymbol: TRBV11-1
name: T cell receptor beta variable 11-1
length: 115
go: ENSG00000211720;
opentargets: plasma membrane [GO:0005886]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSTRLLCWMALCLLGAELSEAEVAQSPRYKITEKSQAVAFWCDPISGHATLYWYRQILGQGPELLVQFQDESVVDDSQLPKDRFSAERLKGVDSTLKIQPAELGDSAMYLCASSL


uniprotID: A0A0B4J262
geneSymbol: TRAV8-6
name: T cell receptor alpha variable 8-6
length: 113
go: ENSG00000211795;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLLLVPAFQVIFTLGGTRAQSVTQLDSQVPVFEEAPVELRCNYSSSVSVYLFWYVQYPNQGLQLLLKYLSGSTLVESINGFEAEFNKSQTSFHLRKPSVHISDTAEYFCAVS


uniprotID: A0A087WT02
geneSymbol: TRAV9-2
name: T cell receptor alpha variable 9-2
length: 112
go: ENSG00000211793;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MNYSPGLVSLILLLLGRTRGDSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYPGEGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSVQVSDSAVYFCALS

opentargets:
extracellular space [GO:0005615]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; immunoglobulin production [GO:0002377]


uniprotID: A0A075B6T6
geneSymbol: TRAV12-2
pdb: 1AO7;4ZDH;5NHT;
name: T cell receptor alpha variable 12-2
length: 113
go: ENSG00000211789;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKSLRVLLVILWLQLSWVWSQQKEVEQNSGPLSVPEGAIASLNCTYSDRGSQSFFWYRQYSGKSPELIMFIYSNGDKEDGRFTAQLNKASQYVSLLIRDSQPSDSATYLCAVN


uniprotID: A0A0B4J271
geneSymbol: TRAV12-3
pdb: 4WWK;5C07;5C08;5C09;5C0A;5C0B;5C0C;5HYJ;
name: T cell receptor alpha variable 12-3
length: 114
go: ENSG00000211794;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MMKSLRVLLVILWLQLSWVWSQQKEVEQDPGPLSVPEGAIVSLNCTYSNSAFQYFMWYRQYSRKGPELLMYTYSSGNKEDGRFTAQVDKSSKYISLFIRDSQPSDSATYLCAMS


uniprotID: A0A0B4J241
geneSymbol: TRAV13-1
name: T cell receptor alpha variable 13-1
length: 112
go: ENSG00000211788;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MTSIRAVFIFLWLQLDLVNGENVEQHPSTLSVQEGDSAVIKCTYSDSASNYFPWYKQELGKGPQLIIDIRSNVGEKKDQRIAVTLNKTAKHFSLHITETQPEDSAVYFCAAS


uniprotID: A0A0B4J235
geneSymbol: TRAV13-2
name: T cell receptor alpha variable 13-2
length: 113
go: ENSG00000211791;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MAGIRALFMYLWLQLDWVSRGESVGLHLPTLSVQEGDNSIINCAYSNSASDYFIWYKQESGKGPQFIIDIRSNMDKRQGQRVTVLLNKTVKHLSLQIAATQPGDSAVYFCAEN


uniprotID: A0A075B6X5
geneSymbol: TRAV18
name: T cell receptor alpha variable 18
length: 111
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLSASCSGLVILLIFRRTSGDSVTQTEGPVTLPERAALTLNCTYQSSYSTFLFWYVQYLNKEPELLLKSSENQETDSRGFQASPIKSDSSFHLEKPSVQLSDSAVYYCALR

opentargets:
extracellular space [GO:0005615]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; immunoglobulin production [GO:0002377]


uniprotID: A0A0K0K1C4
geneSymbol: TRBV27
name: T cell receptor beta variable 27
length: 114
go: ENSG00000211752;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGPQLLGYVVLCLLGAGPLEAQVTQNPRYLITVTGKKLTVTCSQNMNHEYMSWYRQDPGLGLRQIYYSMNVEVTDKGDVPEGYKVSRKEKRNFPLILESPSPNQTSLYFCASSL


uniprotID: A0A5B7
geneSymbol: TRBV29-1
name: T cell receptor beta variable 29-1
length: 111
go: ENSG00000232869;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLSLLLLLLGLGSVFSAVISQKPSRDICQRGTSLTIQCQVDSQVTMMFWYRQQPGQSLTLIATANQGSEATYESGFVIDKFPISRPNLTFSTLTVSNMSPEDSSIYLCSVE


uniprotID: A0A0B4J277
geneSymbol: TRAV22
pdb: 4UDT;4UDU;5FK9;5FKA;
name: T cell receptor alpha variable 22
length: 110
go: ENSG00000211802;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKRILGALLGLLSAQVCCVRGIQVEQSPPDLILQEGANSTLRCNFSDSVNNLQWFHQNPWGQLINLFYIPSGTKQNGRLSATTVATERYSLLYISSSQTTDSGVYFCAVE


uniprotID: A0A576
geneSymbol: TRBV3-1
name: T cell receptor beta variable 3-1
length: 114
go: ENSG00000237702;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGCRLLCCVVFCLLQAGPLDTAVSQTPKYLVTQMGNDKSIKCEQNLGHDTMYWYKQDSKKFLKIMFSYNNKELIINETVPNRFSPKSPDKAHLNLHINSLELGDSAVYFCASSQ


uniprotID: A0A577
geneSymbol: TRBV4-1
name: T cell receptor beta variable 4-1
length: 114
go: ENSG00000211710;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGCRLLCCAVLCLLGAVPIDTEVTQTPKHLVMGMTNKKSLKCEQHMGHRAMYWYKQKAKKPPELMFVYSYEKLSINESVPSRFSPECPNSSLLNLHLHALQPEDSALYLCASSQ


uniprotID: A0A578
geneSymbol: TRBV5-1
pdb: 5BRZ;5BS0;
name: T cell receptor beta variable 5-1
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGSRLLCWVLLCLLGAGPVKAGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQTPGQGLQFLFEYFSETQRNKGNFPGRFSGRQFSNSRSEMNVSTLELGDSALYLCASSL


uniprotID: A0A0B4J273
geneSymbol: TRAV34
name: T cell receptor alpha variable 34
length: 112
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
METVLQVLLGILGFQAAWVSSQELEQSPQSLIVQEGKNLTINCTSSKTLYGLYWYKQKYGEGLIFLMMLQKGGEEKSHEKITAKLDEKKQQSSLHITASQPSHAGIYLCGAD


uniprotID: A0A0B4J244
geneSymbol: TRAV3
name: T cell receptor alpha variable 3
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MASAPISMLAMLFTLSGLRAQSVAQPEDQVNVAEGNPLTVKCTYSVSGNPYLFWYVQYPNRGLQFLLKYITGDNLVKGSYGFEAEFNKSQTSFHLKKPSALVSDSALYFCAVRD


uniprotID: A0A0B4J280
geneSymbol: TRAV40
name: T cell receptor alpha variable 40
length: 105
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MNSSLDFLILILMFGGTSSNSVKQTGQITVSEGASVTMNCTYTSTGYPTLFWYVEYPSKPLQLLQRETMENSKNFGGGNIKDKNSPIVKYSVQVSDSAVYYCLLG

opentargets:
extracellular space [GO:0005615]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; immunoglobulin production [GO:0002377]


uniprotID: A0A1B0GX49
geneSymbol: TRBV6-4
name: T cell receptor beta variable 6-4
length: 114
go: ENSG00000211713;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSIRLLCCVAFSLLWAGPVTAGITQAPTSQILAAGRSMTLRCTQDMRHNAMYWYRQDLGLGLRLIHYSNTAGTTGKGEVPDGYSVSRANTDDFPLTLASAVPSQTSVYFCASSD


uniprotID: A0A1B0GX31
geneSymbol: TRBV7-6
name: T cell receptor beta variable 7-6
length: 115
go: ENSG00000211727;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTSLLCWVVLGFLGTDHTGAGVSQSPRYKVTKRGQDVALRCDPISGHVSLYWYRQALGQGPEFLTYFNYEAQQDKSGLPNDRFSAERPEGSISTLTIQRTEQRDSAMYRCASSL


uniprotID: A0A1B0GX51
geneSymbol: TRBV7-8
name: T cell receptor beta variable 7-8
length: 115
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLLCWVVLGFLGTDHTGAGVSQSPRYKVAKRGQDVALRCDPISGHVSLFWYQQALGQGPEFLTYFQNEAQLDKSGLPSDRFFAERPEGSVSTLKIQRTQQEDSAVYLCASSL


uniprotID: P04435
geneSymbol: TRBV7-9
reactome: R-HSA-198933;R-HSA-202424;R-HSA-202427;R-HSA-202430;R-HSA-202433;R-HSA-389948;
name: T cell receptor beta variable 7-9
length: 115
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTSLLCWMALCLLGADHADTGVSQNPRHKITKRGQNVTFRCDPISEHNRLYWYRQTLGQGPEFLTYFQNEAQLEKSRLLSDRFSAERPKGSFSTLEIQRTEQGDSAMYLCASSL

opentargets:
plasma membrane [GO:0005886]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]


uniprotID: Q9BXU2
geneSymbol: TEX13B
name: Testis-expressed protein 13B
length: 312
go: ENSG00000170925;
sequence:


uniprotID: A0A0J9YWL9
geneSymbol: TEX13C
name: Putative testis-expressed protein 13C
length: 993
opentargets: metal ion binding [GO:0046872]
sequence:


uniprotID: Q6UWH6
geneSymbol: TEX261
name: Protein TEX261
length: 196
go: ENSG00000144043;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MWFMYLLSWLSLFIQVAFITLAVAAGLYYLAELIEEYTVATSRIIKYMIWFSTAVLIGLYVFERFPTSMIGVGLFTNLVYFGLLQTFPFIMLTSPNFILSCGLVVVNHYLAFQFFAEEYYPFSEVLAYFTFCLWIIPFAFFVSLSAGENVLPSTMQPGDDVVSNYFTKGKRGKRLGILVVFSFIKEAILPSRQKIY

opentargets:
COPII-coated ER to Golgi transport vesicle [GO:0030134]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of Golgi membrane [GO:0030173]; COPII adaptor activity [GO:0097020]; ER to Golgi vesicle-mediated transport [GO:0006888]


uniprotID: Q9GZX9
geneSymbol: TWSG1
name: Twisted gastrulation protein homolog 1
length: 223
go: ENSG00000128791;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
sequence:

opentargets:
extracellular space [GO:0005615]; transforming growth factor beta binding [GO:0050431]; BMP signaling pathway [GO:0030509]; camera-type eye development [GO:0043010]; cell differentiation [GO:0030154]; forebrain development [GO:0030900]; hemopoiesis [GO:0030097]; mesoderm formation [GO:0001707]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of CD4-positive, alpha-beta T cell activation [GO:2000515]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of cytokine production [GO:0001818]; negative regulation of osteoblast differentiation [GO:0045668]; ossification [GO:0001503]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; salivary gland morphogenesis [GO:0007435]; transforming growth factor beta receptor signaling pathway [GO:0007179]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9GZX9-1; Sequence=Displayed; Name=2; IsoId=Q9GZX9-2; Sequence=VSP_042538, VSP_042539; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q9P2K2
geneSymbol: TXNDC16
name: Thioredoxin domain-containing protein 16
length: 825
go: ENSG00000087301;
snps: rs28759013 rs28593180 rs7155490
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; cell redox homeostasis [GO:0045454]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25122923}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:21359175, ECO:0000269|PubMed:25122923}.


uniprotID: Q9BRA2
geneSymbol: TXNDC17
pdb: 1WOU;
length: 123
go: ENSG00000129235;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14607844}.
name:
Thioredoxin domain-containing protein 17 (14 kDa thioredoxin-related protein) (TRP14) (Protein 42-9-9) (Thioredoxin-like protein 5)

sequence:
MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; peroxidase activity [GO:0004601]; protein-disulfide reductase activity [GO:0047134]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: P42681
geneSymbol: TXK
reactome: R-HSA-2871809;
pdb: 2DM0;
name: Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)
length: 527
go: ENSG00000074966;
snps: rs7658300 rs41265727 rs11724347
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II regulatory region DNA binding [GO:0001012]; activation of phospholipase C activity [GO:0007202]; adaptive immune response [GO:0002250]; cytokine production [GO:0001816]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interferon-gamma-mediated signaling pathway [GO:0060335]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; T cell receptor signaling pathway [GO:0050852]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17177976}. Nucleus {ECO:0000269|PubMed:17177976}. Cell membrane {ECO:0000269|PubMed:17177976}; Peripheral membrane protein {ECO:0000269|PubMed:17177976}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.


uniprotID: Q8N3L3
geneSymbol: TXLNB
name: Beta-taxilin (Muscle-derived protein 77) (hMDP77)
length: 684
go: ENSG00000164440;
opentargets: cytoplasm [GO:0005737]; syntaxin binding [GO:0019905]
snps: rs9321712 rs17068451 rs9495392 rs9495391
sequence:


uniprotID: Q9NUQ3
geneSymbol: TXLNG
length: 528
go: ENSG00000086712;
snps: rs5969783
name:
Gamma-taxilin (Environmental lipopolysaccharide-responding gene protein) (Factor inhibiting ATF4-mediated transcription) (FIAT) (Lipopolysaccharide-specific response protein 5)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear membrane [GO:0031965]; protein heterodimerization activity [GO:0046982]; syntaxin binding [GO:0019905]; cell cycle [GO:0007049]; regulation of bone mineralization [GO:0030500]; regulation of cell cycle [GO:0051726]; regulation of cell cycle process [GO:0010564]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NUQ3-1; Sequence=Displayed; Name=2; IsoId=Q9NUQ3-2; Sequence=VSP_039391; 

location:
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15911876}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BHN1}.


uniprotID: Q8NBS9
geneSymbol: TXNDC5
reactome: R-HSA-432720;R-HSA-432722;R-HSA-6798695;
pdb: 2DIZ;3UJ1;3UVT;3WGD;3WGE;3WGX;
length: 432
go: ENSG00000239264;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
name:
Thioredoxin domain-containing protein 5 (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)

sequence:

opentargets:
azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; lysosomal lumen [GO:0043202]; isomerase activity [GO:0016853]; apoptotic cell clearance [GO:0043277]; cell redox homeostasis [GO:0045454]; negative regulation of apoptotic process [GO:0043066]; neutrophil degranulation [GO:0043312]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NBS9-1; Sequence=Displayed; Name=2; IsoId=Q8NBS9-2; Sequence=VSP_045181; Note=No experimental confirmation available.; 


uniprotID: Q86XW9
geneSymbol: NME9
name: Thioredoxin domain-containing protein 6 (Thioredoxin-like protein 2) (Txl-2)
length: 330
go: ENSG00000181322;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoside diphosphate kinase activity [GO:0004550]; cell redox homeostasis [GO:0045454]; CTP biosynthetic process [GO:0006241]; GTP biosynthetic process [GO:0006183]; UTP biosynthetic process [GO:0006228]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86XW9-1; Sequence=Displayed; Name=2; IsoId=Q86XW9-2; Sequence=VSP_010375, VSP_010377, VSP_010378; Note=No experimental confirmation available.; Name=3; IsoId=Q86XW9-3; Sequence=VSP_010376, VSP_010378; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity). {ECO:0000250}.


uniprotID: Q8N427
geneSymbol: NME8
length: 588
go: ENSG00000086288;
snps: rs2722372 rs10250905 rs56128139
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11737268}.
name:
Thioredoxin domain-containing protein 3 (NM23-H8) (NME/NM23 family member 8) (Spermatid-specific thioredoxin-2) (Sptrx-2)

sequence:

opentargets:
outer dynein arm [GO:0036157]; sperm cytoplasmic droplet [GO:0097598]; sperm principal piece [GO:0097228]; microtubule binding [GO:0008017]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; cellular response to reactive oxygen species [GO:0034614]; cilium assembly [GO:0060271]; flagellated sperm motility [GO:0030317]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]


uniprotID: P53007
geneSymbol: SLC25A1
reactome: R-HSA-70263;R-HSA-75105;
length: 311
go: ENSG00000100075;
snps: rs781925968 rs782335811 rs431905509 rs431905509
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
name:
Tricarboxylate transport protein, mitochondrial (Citrate transport protein) (CTP) (Solute carrier family 25 member 1) (Tricarboxylate carrier protein)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]; citrate transmembrane transporter activity [GO:0015137]; tricarboxylic acid transmembrane transporter activity [GO:0015142]; fatty-acyl-CoA biosynthetic process [GO:0046949]; gluconeogenesis [GO:0006094]; mitochondrial citrate transmembrane transport [GO:0006843]


uniprotID: Q8TAI1
geneSymbol: TYMSOS
name: TYMS opposite strand protein
length: 123
snps: rs2853533
sequence:
MTPASGATASLGRLRARPRSRWDAAYLPAVAAVCVARASHVPNGTLRFGVCKARRTMRPLPRRIEVRTKRGPQRPAAPERSPQPRLPPSRHPSRRGPRRHLSGCSAPACRIPTGCRCPCGRPS


uniprotID: P40126
geneSymbol: DCT
reactome: R-HSA-5662702;
pdb: 4HX1;
length: 519
go: ENSG00000080166;
name:
L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)

sequence:

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; copper ion binding [GO:0005507]; dopachrome isomerase activity [GO:0004167]; oxidoreductase activity [GO:0016491]; cell development [GO:0048468]; developmental pigmentation [GO:0048066]; epidermis development [GO:0008544]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; positive regulation of neuroblast proliferation [GO:0002052]; ventricular zone neuroblast division [GO:0021847]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P40126-1; Sequence=Displayed; Name=2; Synonyms=TRP-2-6b; IsoId=P40126-2; Sequence=VSP_043581; 

location:
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000250|UniProtKB:P29812}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P29812}.


uniprotID: Q8NFQ8
geneSymbol: TOR1AIP2
pdb: 5J1S;5J1T;
name: Torsin-1A-interacting protein 2 (Lumenal domain-like LAP1)
length: 470
go: ENSG00000169905;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; nuclear membrane [GO:0031965]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; endoplasmic reticulum organization [GO:0007029]; positive regulation of ATPase activity [GO:0032781]; protein localization to nuclear envelope [GO:0090435]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=TOR1AIP2; IsoId=Q8NFQ8-1; Sequence=Displayed; Name=IFRG15; IsoId=Q9H496-1; Sequence=External; Note=No experimental confirmation available. Dubious isoform.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane.


uniprotID: O60784
geneSymbol: TOM1
reactome: R-HSA-6798695;
pdb: 1ELK;1WRD;2N2N;2N9D;
name: Target of Myb protein 1
length: 492
go: ENSG00000100284;
snps: rs11558473 rs34371697
sequence:

opentargets:
azurophil granule membrane [GO:0035577]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; clathrin binding [GO:0030276]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O60784-1; Sequence=Displayed; Name=2; IsoId=O60784-2; Sequence=VSP_038366; Note=No experimental confirmation available.; Name=3; IsoId=O60784-3; Sequence=VSP_038365; Note=No experimental confirmation available.; Name=4; IsoId=O60784-4; Sequence=VSP_038364, VSP_038366; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.


uniprotID: P02585
geneSymbol: TNNC2
reactome: R-HSA-390522;
name: Troponin C, skeletal muscle
length: 160
go: ENSG00000101470;
drug: DB01373;DB01023;DB04682;
sequence:
MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGTIDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGDKNNDGRIDFDEFLKMMEGVQ

opentargets:
cytosol [GO:0005829]; troponin complex [GO:0005861]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; muscle filament sliding [GO:0030049]; regulation of muscle contraction [GO:0006937]; skeletal muscle contraction [GO:0003009]


uniprotID: Q9H3S4
geneSymbol: TPK1
reactome: R-HSA-196819;
pdb: 1OLY;3S4Y;
length: 243
go: ENSG00000196511;
drug: DB04768;DB00152;
snps: rs387906936 rs387906935 rs371271054
name:
Thiamin pyrophosphokinase 1 (hTPK1) (EC 2.7.6.2) (Placental protein 20) (PP20) (Thiamine pyrophosphokinase 1)

sequence:

opentargets:
cytosol [GO:0005829]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; thiamine binding [GO:0030975]; thiamine diphosphokinase activity [GO:0004788]; thiamine diphosphate biosynthetic process [GO:0009229]; thiamine metabolic process [GO:0006772]; thiamine-containing compound metabolic process [GO:0042723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H3S4-1; Sequence=Displayed; Name=2; IsoId=Q9H3S4-2; Sequence=VSP_056302, VSP_056303; Note=No experimental confirmation available.; 


uniprotID: P20396
geneSymbol: TRH
reactome: R-HSA-375276;R-HSA-416476;
length: 242
go: ENSG00000170893;
snps: rs5658
location: SUBCELLULAR LOCATION: Secreted.
name:
Pro-thyrotropin-releasing hormone (Pro-TRH) (Prothyroliberin) [Cleaved into: Thyrotropin-releasing hormone (TRH) (Protirelin) (TSH-releasing factor) (Thyroliberin) (Thyrotropin-releasing factor) (TRF)]

sequence:

opentargets:
extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; thyrotropin-releasing hormone activity [GO:0008437]; adult walking behavior [GO:0007628]; cell-cell signaling [GO:0007267]; eating behavior [GO:0042755]; G protein-coupled receptor signaling pathway [GO:0007186]; histamine metabolic process [GO:0001692]; hormone-mediated signaling pathway [GO:0009755]; negative regulation of feeding behavior [GO:2000252]; negative regulation of glutamate secretion [GO:0014050]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of insulin secretion [GO:0032024]; response to cold [GO:0009409]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to glucose [GO:0009749]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]


uniprotID: Q9BQ50
geneSymbol: TREX2
pdb: 1Y97;
name: Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2)
length: 279
go: ENSG00000183479;
snps: rs35132777
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; 3'-5'-exodeoxyribonuclease activity [GO:0008296]; exodeoxyribonuclease III activity [GO:0008853]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; protein homodimerization activity [GO:0042803]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BQ50-1; Sequence=Displayed; Name=2; IsoId=Q9BQ50-2; Sequence=VSP_010447; 


uniprotID: Q9UDY6
geneSymbol: TRIM10
reactome: R-HSA-877300;
name: Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9)
length: 481
go: ENSG00000204613;
snps: rs12212092 rs17194446
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11331580}.
sequence:

opentargets:
cytoplasm [GO:0005737]; zinc ion binding [GO:0008270]; erythrocyte differentiation [GO:0030218]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Alpha; IsoId=Q9UDY6-1; Sequence=Displayed; Name=Beta; IsoId=Q9UDY6-2; Sequence=VSP_005748; 


uniprotID: Q96BQ3
geneSymbol: TRIM43
name: Tripartite motif-containing protein 43
length: 446
go: ENSG00000144015;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: Q8IYL2
geneSymbol: TRMT44
reactome: R-HSA-6782315;
name: Probable tRNA (uracil-O(2)-)-methyltransferase (EC 2.1.1.211) (Methyltransferase-like protein 19)
length: 757
snps: rs73211375 rs1880024 rs34873641 rs150441746
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; tRNA (uracil) methyltransferase activity [GO:0016300]; tRNA methylation [GO:0030488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IYL2-1; Sequence=Displayed; Name=2; IsoId=Q8IYL2-2; Sequence=VSP_020589, VSP_020590, VSP_020591, VSP_020592; Note=No experimental confirmation available.; Name=3; IsoId=Q8IYL2-3; Sequence=VSP_039538; 


uniprotID: Q96F44
geneSymbol: TRIM11
reactome: R-HSA-983168;
length: 468
go: ENSG00000154370;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
name:
E3 ubiquitin-protein ligase TRIM11 (EC 2.3.2.27) (Protein BIA1) (RING finger protein 92) (RING-type E3 ubiquitin transferase TRIM11) (Tripartite motif-containing protein 11)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein domain specific binding [GO:0019904]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of neurogenesis [GO:0050768]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of viral entry into host cell [GO:0046598]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96F44-1; Sequence=Displayed; Name=2; IsoId=Q96F44-2; Sequence=VSP_012057, VSP_012058; Note=No experimental confirmation available.; Name=3; IsoId=Q96F44-3; Sequence=VSP_039628; Note=May be due to competing acceptor splice site. No experimental confirmation available.; 


uniprotID: Q96LD4
geneSymbol: TRIM47
length: 638
go: ENSG00000132481;
snps: rs1047043
name:
E3 ubiquitin-protein ligase TRIM47 (EC 2.3.2.27) (Gene overexpressed in astrocytoma protein) (RING finger protein 100) (Tripartite motif-containing protein 47)

sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; ligase activity [GO:0016874]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96LD4-1; Sequence=Displayed; Name=2; IsoId=Q96LD4-2; Sequence=VSP_055440; Note=No experimental confirmation available. {ECO:0000244|PubMed:22814378}; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11511098}. Nucleus {ECO:0000269|PubMed:11511098}.


uniprotID: Q14142
geneSymbol: TRIM14
reactome: R-HSA-877300;
name: Tripartite motif-containing protein 14
length: 442
go: ENSG00000106785;
snps: rs2296079
sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=Alpha; IsoId=Q14142-1; Sequence=Displayed; Name=Beta; IsoId=Q14142-2; Sequence=VSP_000510, VSP_000511; Name=3; IsoId=Q14142-3; Sequence=VSP_044099; Name=4; IsoId=Q14142-4; Sequence=VSP_044097, VSP_044098, VSP_044099; 

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:29053956}.


uniprotID: Q9P272
geneSymbol: TRMT9B
reactome: R-HSA-6782315;
name: Probable tRNA methyltransferase 9B (Probable tRNA methyltransferase 9-like protein) (EC 2.1.1.-)
length: 454
go: ENSG00000250305;
snps: rs757023992 rs528255 rs3739310 rs505480 rs3739308 rs502882 rs34995506 rs608052
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706]; tRNA (uracil) methyltransferase activity [GO:0016300]; tRNA binding [GO:0000049]; tRNA methyltransferase activity [GO:0008175]; tRNA modification [GO:0006400]; tRNA wobble uridine modification [GO:0002098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P272-1; Sequence=Displayed; Name=2; IsoId=Q9P272-3; Sequence=VSP_059378, VSP_059379; 


uniprotID: Q32P41
geneSymbol: TRMT5
reactome: R-HSA-6782861;
length: 509
snps: rs7142228 rs2882686 rs2296928
name:
tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog)

sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; tRNA (guanine(37)-N(1))-methyltransferase activity [GO:0052906]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA methyltransferase activity [GO:0008175]; mitochondrial tRNA methylation [GO:0070901]; tRNA methylation [GO:0030488]; tRNA N1-guanine methylation [GO:0002939]

location:
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03152, ECO:0000269|PubMed:26189817}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03152}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03152}. Note=Predominantly in the mitochondria and in the nucleus. {ECO:0000255|HAMAP-Rule:MF_03152}.


uniprotID: Q9BZY9
geneSymbol: TRIM31
reactome: R-HSA-877300;
pdb: 2YSJ;2YSL;
length: 425
go: ENSG00000204616;
snps: rs36063651 rs3734838 rs2523989 rs35775852 rs1116221
name:
E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM31) (Tripartite motif-containing protein 31)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein ubiquitination [GO:0016567]; regulation of viral release from host cell [GO:1902186]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Alpha; IsoId=Q9BZY9-1; Sequence=Displayed; Name=Beta; IsoId=Q9BZY9-2; Sequence=VSP_005764, VSP_005765; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18773414}. Mitochondrion {ECO:0000269|PubMed:18773414}. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.


uniprotID: Q9UPN9
geneSymbol: TRIM33
reactome: R-HSA-2173795;
pdb: 3U5M;3U5N;3U5O;3U5P;5MR8;
length: 1127
go: ENSG00000197323;
snps: rs6691166 rs56151583 rs6537825 rs55688622 rs55784699
name:
E3 ubiquitin-protein ligase TRIM33 (EC 2.3.2.27) (Ectodermin homolog) (RET-fused gene 7 protein) (Protein Rfg7) (RING-type E3 ubiquitin transferase TRIM33) (Transcription intermediary factor 1-gamma) (TIF1-gamma) (Tripartite motif-containing protein 33)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; co-SMAD binding [GO:0070410]; DNA binding [GO:0003677]; R-SMAD binding [GO:0070412]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; protein ubiquitination [GO:0016567]; regulation of transforming growth factor beta receptor signaling pathway [GO:0017015]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Alpha; IsoId=Q9UPN9-1; Sequence=Displayed; Name=Beta; IsoId=Q9UPN9-2; Sequence=VSP_005774; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15820681, ECO:0000269|PubMed:16751102, ECO:0000269|PubMed:19135894}. Note=In discrete nuclear dots resembling nuclear bodies. {ECO:0000250}.


uniprotID: O00635
geneSymbol: TRIM38
reactome: R-HSA-877300;
length: 465
go: ENSG00000112343;
snps: rs10317
name:
E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (RING-type E3 ubiquitin transferase TRIM38) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)

sequence:

opentargets:
cytosol [GO:0005829]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of defense response to virus [GO:0050687]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of viral entry into host cell [GO:0046598]; positive regulation of viral genome replication [GO:0045070]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; regulation of interferon-beta production [GO:0032648]


uniprotID: Q86VQ6
geneSymbol: TXNRD3
pdb: 3H8Q;
length: 643
go: ENSG00000197763;
name:
Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2)

sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; protein disulfide oxidoreductase activity [GO:0015035]; thioredoxin-disulfide reductase activity [GO:0004791]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum {ECO:0000250}. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000250|UniProtKB:Q99MD6}.


uniprotID: Q16881
geneSymbol: TXNRD1
reactome: R-HSA-1989781;R-HSA-2408550;R-HSA-3299685;R-HSA-499943;R-HSA-5263617;R-HSA-5336415;R-HSA-5628897;
pdb: 1W1C;2CFY;2J3N;2ZZ0;2ZZB;2ZZC;3QFA;3QFB;
length: 649
go: ENSG00000198431;
drug: DB01169;DB03147;DB04106;DB05428;DB02338;DB05448;DB03566;
snps: rs1127954
name:
Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; methylseleninic acid reductase activity [GO:0098626]; methylselenol reductase activity [GO:0098625]; protein disulfide oxidoreductase activity [GO:0015035]; thioredoxin-disulfide reductase activity [GO:0004791]; cell proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; mesoderm formation [GO:0001707]; nucleobase-containing small molecule interconversion [GO:0015949]; regulation of lipid metabolic process [GO:0019216]; selenium compound metabolic process [GO:0001887]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=V, TXNRD1_v3; IsoId=Q16881-1; Sequence=Displayed; Note=Minor isoform.; Name=2; Synonyms=II, TXNRD1_v4; IsoId=Q16881-2; Sequence=VSP_031560, VSP_031565; Name=3; Synonyms=III, TXNRD1_v5; IsoId=Q16881-3; Sequence=VSP_031562, VSP_031563; Name=4; Synonyms=IV, TXNRD1_v2, TrxR1b; IsoId=Q16881-4; Sequence=VSP_031561, VSP_031564; Name=5; Synonyms=I, TXNRD1_v1, TrxR1a; IsoId=Q16881-5; Sequence=VSP_031558; Note=Major isoform. The N-terminus of the sequence is processed into a mature form that lacks residues Met-151 and Asn-152 at the N-terminus. {ECO:0000244|PubMed:19413330, ECO:0000244|PubMed:22223895}; Name=6; Synonyms=VI; IsoId=Q16881-6; Sequence=VSP_031559; Name=7; IsoId=Q16881-7; Sequence=VSP_053819; Note=No experimental confirmation.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 5: Cytoplasm.


uniprotID: Q99816
geneSymbol: TSG101
reactome: R-HSA-162588;R-HSA-174490;R-HSA-917729;
pdb: 1KPP;1KPQ;1M4P;1M4Q;1S1Q;2F0R;3IV1;3OBQ;3OBS;3OBU;3OBX;3P9G;3P9H;4EJE;4YC1;4ZNY;5VKG;
name: Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)
length: 390
go: ENSG00000074319;
snps: rs34385327
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; microtubule organizing center [GO:0005815]; multivesicular body [GO:0005771]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; DNA binding [GO:0003677]; nuclear receptor transcription coactivator activity [GO:0030374]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; transcription corepressor activity [GO:0003714]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; virion binding [GO:0046790]; autophagosome maturation [GO:0097352]; cell cycle arrest [GO:0007050]; cell division [GO:0051301]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; exosomal secretion [GO:1990182]; extracellular transport [GO:0006858]; keratinocyte differentiation [GO:0030216]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; protein monoubiquitination [GO:0006513]; protein transport [GO:0015031]; regulation of cell growth [GO:0001558]; regulation of extracellular exosome assembly [GO:1903551]; regulation of MAP kinase activity [GO:0043405]; regulation of viral budding via host ESCRT complex [GO:1903772]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist. Several shorter isoforms are detected in primary breast cancers and other tumors.; Name=1; IsoId=Q99816-1; Sequence=Displayed; Name=2; IsoId=Q99816-2; Sequence=VSP_004440; Note=Detected in normal as well as cancer tissues.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17853893}. Early endosome membrane {ECO:0000269|PubMed:23166352}; Peripheral membrane protein {ECO:0000305|PubMed:23166352}; Cytoplasmic side {ECO:0000305|PubMed:23166352}. Late endosome membrane {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17229889}; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17853893}. Midbody, Midbody ring {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. Nucleus {ECO:0000269|PubMed:17229889}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}.


uniprotID: Q8NHM4
geneSymbol: PRSS3P2
name: Putative trypsin-6 (EC 3.4.21.4) (Serine protease 3 pseudogene 2) (Trypsinogen C)
length: 247
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular space [GO:0005615]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; endothelial cell migration [GO:0043542]; proteolysis [GO:0006508]


uniprotID: Q96QS1
geneSymbol: TSPAN32
name: Tetraspanin-32 (Tspan-32) (Protein Phemx)
length: 320
go: ENSG00000064201;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]; integrin alphaIIb-beta3 complex [GO:0070442]; intracellular [GO:0005622]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; defense response to protozoan [GO:0042832]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of cell proliferation [GO:0008285]; negative regulation of myeloid dendritic cell activation [GO:0030886]; platelet aggregation [GO:0070527]; regulation of defense response to virus [GO:0050688]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q96QS1-1; Sequence=Displayed; Name=2; IsoId=Q96QS1-2; Sequence=VSP_003932; Name=3; IsoId=Q96QS1-3; Sequence=VSP_003937, VSP_003938; Name=4; IsoId=Q96QS1-4; Sequence=VSP_003932, VSP_003933, VSP_003934; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q96QS1-5; Sequence=VSP_003935, VSP_003936; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: O14817
geneSymbol: TSPAN4
name: Tetraspanin-4 (Tspan-4) (Novel antigen 2) (NAG-2) (Transmembrane 4 superfamily member 7)
length: 238
go: ENSG00000214063;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
focal adhesion [GO:0005925]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; antigen binding [GO:0003823]; integrin binding [GO:0005178]; cell surface receptor signaling pathway [GO:0007166]; protein-containing complex assembly [GO:0065003]


uniprotID: Q9BXA7
geneSymbol: TSSK1B
length: 367
go: ENSG00000212122;
snps: rs747955728 rs55930004 rs55940513 rs55738530 rs34696815 rs11953478
name:
Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250}.


uniprotID: Q9BY10
geneSymbol: SLC46A2
name: Thymic stromal cotransporter homolog (Solute carrier family 46 member 2)
length: 475
go: ENSG00000119457;
snps: rs16917454
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; symporter activity [GO:0015293]; negative regulation of T cell apoptotic process [GO:0070233]; regulation of T cell differentiation [GO:0045580]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]


uniprotID: O95801
geneSymbol: TTC4
name: Tetratricopeptide repeat protein 4 (TPR repeat protein 4)
length: 387
go: ENSG00000243725;
snps: rs1147990
sequence:


uniprotID: Q9H892
geneSymbol: TTC12
name: Tetratricopeptide repeat protein 12 (TPR repeat protein 12)
length: 705
go: ENSG00000149292;
opentargets: centrosome [GO:0005813]
snps: rs723077 rs35852218 rs35303225
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H892-1; Sequence=Displayed; Name=2; IsoId=Q9H892-2; Sequence=VSP_009119; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q8N831
geneSymbol: TSPYL6
name: Testis-specific Y-encoded-like protein 6 (TSPY-like protein 6)
length: 410
go: ENSG00000178021;
opentargets: nucleus [GO:0005634]; nucleosome assembly [GO:0006334]
snps: rs6743719 rs843704 rs13424808 rs17189743
sequence:


uniprotID: Q49AM3
geneSymbol: TTC31
name: Tetratricopeptide repeat protein 31 (TPR repeat protein 31)
length: 519
go: ENSG00000115282;
snps: rs6707475 rs35852562
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q49AM3-1; Sequence=Displayed; Name=2; IsoId=Q49AM3-2; Sequence=VSP_023990, VSP_023991; 


uniprotID: A8MYJ7
geneSymbol: TTC34
name: Tetratricopeptide repeat protein 34 (TPR repeat protein 34)
length: 566
go: ENSG00000215912;
sequence:


uniprotID: A6NLP5
geneSymbol: TTC36
name: Tetratricopeptide repeat protein 36 (TPR repeat protein 36) (HSP70-binding protein 21)
length: 189
go: ENSG00000172425;
snps: rs7111428
sequence:
MGTPNDQAVLQAIFNPDTPFGDIVGLDLGEEAEKEEREEDEVFPQAQLEQSKALELQGVMAAEAGDLSTALERFGQAICLLPERASAYNNRAQARRLQGDVAGALEDLERAVELSGGRGRAARQSFVQRGLLARLQGRDDDARRDFERAARLGSPFARRQLVLLNPYAALCNRMLADMMGQLRRPRDSR

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NLP5-1; Sequence=Displayed; Name=2; IsoId=A6NLP5-2; Sequence=VSP_055760; Note=No experimental confirmation available.; 


uniprotID: P33981
geneSymbol: TTK
length: 857
go: ENSG00000112742;
snps: rs2230513 rs2230512
pdb:
2X9E;2ZMC;2ZMD;3CEK;3DBQ;3GFW;3H9F;3HMN;3HMO;3HMP;3VQU;3W1F;3WYX;3WYY;3WZJ;3WZK;4B94;4BHZ;4BI0;4BI1;4BI2;4C4E;4C4F;4C4G;4C4H;4C4I;4C4J;4CV8;4CV9;4CVA;4D2S;4H7X;4H7Y;4JS8;4JT3;4O6L;4ZEG;5AP0;5AP1;5AP2;5AP3;5AP4;5AP5;5AP6;5AP7;5EH0;5EHL;5EHO;5EHY;5EI2;5EI6;5EI8;5LJJ;5MRB;5N7V;5N84;5N87;5N93;5N9S;5NA0;5NAD;5NTT;5O91;6B4W;6H3K;

name:
Dual specificity protein kinase TTK (EC 2.7.12.1) (Phosphotyrosine picked threonine-protein kinase) (PYT)

sequence:

opentargets:
cytoplasm [GO:0005737]; kinetochore [GO:0000776]; membrane [GO:0016020]; spindle [GO:0005819]; ATP binding [GO:0005524]; kinetochore binding [GO:0043515]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; chromosome separation [GO:0051304]; female meiosis chromosome segregation [GO:0016321]; meiotic spindle assembly checkpoint [GO:0033316]; mitotic spindle assembly checkpoint [GO:0007094]; mitotic spindle organization [GO:0007052]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of cell proliferation [GO:0008284]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; protein autophosphorylation [GO:0046777]; protein localization to kinetochore [GO:0034501]; protein localization to meiotic spindle midzone [GO:1903096]; spindle organization [GO:0007051]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P33981-1; Sequence=Displayed; Name=2; IsoId=P33981-2; Sequence=VSP_043072; Note=No experimental confirmation available.; 


uniprotID: Q6ZVT0
geneSymbol: TTLL10
reactome: R-HSA-8955332;
name: Inactive polyglycylase TTLL10 (Tubulin--tyrosine ligase-like protein 10)
length: 673
go: ENSG00000162571;
snps: rs139755178 rs13374146 rs1320571 rs2274791
sequence:

opentargets:
cytosol [GO:0005829]; ATP binding [GO:0005524]; protein-glycine ligase activity [GO:0070735]; protein polyglycylation [GO:0018094]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZVT0-1; Sequence=Displayed; Name=2; IsoId=Q6ZVT0-2; Sequence=VSP_032262; Name=3; IsoId=Q6ZVT0-3; Sequence=VSP_032262, VSP_032263, VSP_032264; 


uniprotID: Q9BWV7
geneSymbol: TTLL2
reactome: R-HSA-8955332;
length: 592
go: ENSG00000120440;
name:
Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2)

sequence:

opentargets:
ATP binding [GO:0005524]; ligase activity [GO:0016874]; cellular protein modification process [GO:0006464]

snps:
rs12526094 rs34350976 rs11540664 rs6936639 rs34286114 rs909545 rs41266331 rs9457304 rs12528714 rs34931196 


uniprotID: Q13454
geneSymbol: TUSC3
reactome: R-HSA-446203;R-HSA-5223345;
pdb: 4M8G;4M90;4M91;4M92;
name: Tumor suppressor candidate 3 (Magnesium uptake/transporter TUSC3) (Protein N33)
length: 348
go: ENSG00000104723;
snps: rs11545035
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of plasma membrane [GO:0005887]; mitochondrion [GO:0005739]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; magnesium ion transmembrane transporter activity [GO:0015095]; cognition [GO:0050890]; magnesium ion transport [GO:0015693]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13454-1; Sequence=Displayed; Name=2; IsoId=Q13454-2; Sequence=VSP_003776; 


uniprotID: Q14679
geneSymbol: TTLL4
reactome: R-HSA-8955332;
pdb: 5T6X;
name: Tubulin polyglutamylase TTLL4 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 4)
length: 1199
go: ENSG00000135912;
snps: rs11542786 rs3731877 rs3731875 rs2114664 rs17851914 rs17851915 rs17856640 rs9989776
sequence:

opentargets:
cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; protein-glutamic acid ligase activity [GO:0070739]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; peptidyl-glutamic acid modification [GO:0018200]; protein polyglutamylation [GO:0018095]

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8}. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000250|UniProtKB:Q80UG8}.


uniprotID: Q8N841
geneSymbol: TTLL6
reactome: R-HSA-8955332;
name: Tubulin polyglutamylase TTLL6 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 6)
length: 843
snps: rs2032844 rs17853181
sequence:

opentargets:
ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; protein-glutamic acid ligase activity [GO:0070739]; tubulin binding [GO:0015631]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; positive regulation of cilium movement [GO:0003353]; protein polyglutamylation [GO:0018095]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:14702039}; IsoId=Q8N841-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16443334}; IsoId=Q8N841-2; Sequence=VSP_052727, VSP_052728; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:22246503}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22246503}. Note=CEP41 is required for its transport between the basal body and the cilium. {ECO:0000269|PubMed:22246503}.


uniprotID: Q9BTX7
geneSymbol: TTPAL
name: Alpha-tocopherol transfer protein-like
length: 342
go: ENSG00000124120;
opentargets: membrane [GO:0016020]
snps: rs59069332
sequence:


uniprotID: A0A0A6YYC5
geneSymbol: TRAV14DV4
name: T cell receptor alpha variable 14/delta variable 4
length: 116
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSLSSLLKVVTASLWLGPGIAQKITQTQPGMFVQEKEAVTLDCTYDTSDPSYGLFWYKQPSSGEMIFLIYQGSYDQQNATEGRYSLNFQKARKSANLVISASQLGDSAMYFCAMRE


uniprotID: A0A0A6YYK6
geneSymbol: TRAV16
name: T cell receptor alpha variable 16
length: 109
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKPTLISVLVIIFILRGTRAQRVTQPEKLLSVFKGAPVELKCNYSYSGSPELFWYVQYSRQRLQLLLRHISRESIKGFTADLNKGETSFHLKKPFAQEEDSAMYYCALS


uniprotID: A0A0B4J275
geneSymbol: TRAV17
name: T cell receptor alpha variable 17
length: 112
go: ENSG00000211797;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
METLLGVSLVILWLQLARVNSQQGEEDPQALSIQEGENATMNCSYKTSINNLQWYRQNSGRGLVHLILIRSNEREKHSGRLRVTLDTSKKSSSLLITASRAADTASYFCATD


uniprotID: A0A0A6YYK7
geneSymbol: TRAV19
reactome: R-HSA-198933;R-HSA-202424;R-HSA-202427;R-HSA-202430;R-HSA-202433;R-HSA-389948;
name: T cell receptor alpha variable 19 (T-cell receptor alpha chain V region HPB-MLT)
length: 116
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLTASLLRAVIASICVVSSMAQKVTQAQTEISVVEKEDVTLDCVYETRDTTYYLFWYKQPPSGELVFLIRRNSFDEQNEISGRYSWNFQKSTSSFNFTITASQVVDSAVYFCALSE

opentargets:
extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; immunoglobulin production [GO:0002377]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]


uniprotID: A0A075B6W5
geneSymbol: TRAV23DV6
name: T cell receptor alpha variable 23/delta variable 6
length: 121
go: ENSG00000211803;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MDKILGASFLVLWLQLCWVSGQQKEKSDQQQVKQSPQSLIVQKGGISIINCAYENTAFDYFPWYQQFPGKGPALLIAIRPDVSEKKEGRFTISFNKSAKQFSSHIMDSQPGDSATYFCAAS


uniprotID: A0A539
geneSymbol: TRBV4-2
name: T cell receptor beta variable 4-2
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGCRLLCCAVLCLLGAVPMETGVTQTPRHLVMGMTNKKSLKCEQHLGHNAMYWYKQSAKKPLELMFVYNFKEQTENNSVPSRFSPECPNSSHLFLHLHTLQPEDSALYLCASSQ


uniprotID: A0A589
geneSymbol: TRBV4-3
name: T cell receptor beta variable 4-3
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGCRLLCCAVLCLLGAVPMETGVTQTPRHLVMGMTNKKSLKCEQHLGHNAMYWYKQSAKKPLELMFVYSLEERVENNSVPSRFSPECPNSSHLFLHLHTLQPEDSALYLCASSQ


uniprotID: A0A597
geneSymbol: TRBV5-5
name: T cell receptor beta variable 5-5
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGPGLLCWVLLCLLGAGPVDAGVTQSPTHLIKTRGQQVTLRCSPISGHKSVSWYQQVLGQGPQFIFQYYEKEERGRGNFPDRFSARQFPNYSSELNVNALLLGDSALYLCASSL


uniprotID: A0A075B6V5
geneSymbol: TRAV36DV7
name: T cell receptor alpha variable 36/delta variable 7
length: 113
go: ENSG00000211815;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MMKCPQALLAIFWLLLSWVSSEDKVVQSPLSLVVHEGDTVTLNCSYEVTNFRSLLWYKQEKKAPTFLFMLTSSGIEKKSGRLSSILDKKELFSILNITATQTGDSAIYLCAVE


uniprotID: Q12792
geneSymbol: TWF1
name: Twinfilin-1 (Protein A6) (Protein tyrosine kinase 9)
length: 350
go: ENSG00000151239;
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; negative regulation of actin filament polymerization [GO:0030837]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of neuron projection development [GO:0010976]; regulation of actin phosphorylation [GO:0043538]; regulation of lamellipodium assembly [GO:0010591]; sequestering of actin monomers [GO:0042989]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000305}; IsoId=Q12792-2; Sequence=Displayed; Name=3; IsoId=Q12792-3; Sequence=VSP_017899; Name=4; IsoId=Q12792-4; Sequence=VSP_038075; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity). {ECO:0000250}.


uniprotID: A0A0J9YX75
geneSymbol: TRBV6-9
name: T cell receptor beta variable 6-9
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSIGLLCCVAFSLLWAGPVNAGVTQTPKFHILKTGQSMTLQCAQDMNHGYLSWYRQDPGMGLRRIHYSVAAGITDKGEVPDGYNVSRSNTEDFPLRLESAAPSQTSVYFCASSY


uniprotID: A0A1B0GXF2
geneSymbol: TRBV7-2
name: T cell receptor beta variable 7-2
length: 115
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLLFWVAFCLLGADHTGAGVSQSPSNKVTEKGKDVELRCDPISGHTALYWYRQSLGQGLEFLIYFQGNSAPDKSGLPSDRFSAERTGGSVSTLTIQRTQQEDSAVYLCASSL


uniprotID: Q9BXU3
geneSymbol: TEX13A
name: Testis-expressed protein 13A
length: 409
go: ENSG00000268629;
opentargets: metal ion binding [GO:0046872]
sequence:


uniprotID: O14907
geneSymbol: TAX1BP3
reactome: R-HSA-5666185;
pdb: 2KG2;2L4S;2L4T;2VZ5;3GJ9;3SFJ;4E3B;4NNL;4NNM;
length: 124
go: ENSG00000213977;
snps: rs1057517690
name:
Tax1-binding protein 3 (Glutaminase-interacting protein 3) (Tax interaction protein 1) (TIP-1) (Tax-interacting protein 1)

sequence:
MSYIPGQPVTAVVQRVEIHKLRQGENLILGFSIGGGIDQDPSQNPFSEDKTDKGIYVTRVSEGGPAEIAGLQIGDKIMQVNGWDMTMVTHDQARKRLTKRSEEVVRLLVTRQSLQKAVQQSMLS

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; fibrillar center [GO:0001650]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; protein C-terminus binding [GO:0008022]; activation of GTPase activity [GO:0090630]; negative regulation of cell proliferation [GO:0008285]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of Wnt signaling pathway [GO:0030178]; Rho protein signal transduction [GO:0007266]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Recruited to the cell membrane by interaction with membrane proteins.


uniprotID: Q9Y6I9
geneSymbol: TEX264
reactome: R-HSA-114608;
name: Testis-expressed protein 264 (Putative secreted protein Zsig11)
length: 313
go: ENSG00000164081;
snps: rs11553574
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; platelet alpha granule lumen [GO:0031093]; platelet degranulation [GO:0002576]


uniprotID: P07101
geneSymbol: TH
reactome: R-HSA-209905;
pdb: 2XSN;4J6S;
name: Tyrosine 3-monooxygenase (EC 1.14.16.2) (Tyrosine 3-hydroxylase) (TH)
length: 528
go: ENSG00000180176;
drug: DB00120;DB00135;DB03552;DB00765;DB00360;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; melanosome membrane [GO:0033162]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perikaryon [GO:0043204]; smooth endoplasmic reticulum [GO:0005790]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]; amino acid binding [GO:0016597]; dopamine binding [GO:0035240]; enzyme binding [GO:0019899]; ferric iron binding [GO:0008199]; ferrous iron binding [GO:0008198]; oxygen binding [GO:0019825]; protein domain specific binding [GO:0019904]; tetrahydrobiopterin binding [GO:0034617]; tyrosine 3-monooxygenase activity [GO:0004511]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; catecholamine biosynthetic process [GO:0042423]; cellular response to alkaloid [GO:0071312]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; cellular response to manganese ion [GO:0071287]; cellular response to nicotine [GO:0071316]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle [GO:0042745]; dopamine biosynthetic process [GO:0042416]; dopamine biosynthetic process from tyrosine [GO:0006585]; eating behavior [GO:0042755]; embryonic camera-type eye morphogenesis [GO:0048596]; epinephrine biosynthetic process [GO:0042418]; eye photoreceptor cell development [GO:0042462]; fatty acid metabolic process [GO:0006631]; glycoside metabolic process [GO:0016137]; heart development [GO:0007507]; heart morphogenesis [GO:0003007]; isoquinoline alkaloid metabolic process [GO:0033076]; learning [GO:0007612]; locomotory behavior [GO:0007626]; mating behavior [GO:0007617]; memory [GO:0007613]; multicellular organism aging [GO:0010259]; neurotransmitter biosynthetic process [GO:0042136]; norepinephrine biosynthetic process [GO:0042421]; phthalate metabolic process [GO:0018963]; phytoalexin metabolic process [GO:0052314]; pigmentation [GO:0043473]; regulation of heart contraction [GO:0008016]; response to activity [GO:0014823]; response to amphetamine [GO:0001975]; response to corticosterone [GO:0051412]; response to electrical stimulus [GO:0051602]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to ether [GO:0045472]; response to herbicide [GO:0009635]; response to hypoxia [GO:0001666]; response to immobilization stress [GO:0035902]; response to isolation stress [GO:0035900]; response to light stimulus [GO:0009416]; response to lipopolysaccharide [GO:0032496]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to pyrethroid [GO:0046684]; response to salt stress [GO:0009651]; response to water deprivation [GO:0009414]; response to zinc ion [GO:0010043]; sensory perception of sound [GO:0007605]; social behavior [GO:0035176]; sphingolipid metabolic process [GO:0006665]; synaptic transmission, dopaminergic [GO:0001963]; terpene metabolic process [GO:0042214]; visual perception [GO:0007601]

snps:
rs766704202 rs6356 rs80338892 rs121917763 rs762304556 rs28934581 rs755536257 rs199961079 rs121917764 rs1288483479 rs28934580 rs121917765 rs763039181 rs1057520384 rs745551241 rs121917762 rs370962049 rs367874223 rs767635052 rs45471299 rs771351747 rs1800033 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=TH transcripts lacking exons 8 and 9 present concomitant splicing in exons 1b and 2.; Name=3; Synonyms=TH type 4; IsoId=P07101-1; Sequence=Displayed; Name=1; Synonyms=TH type 3; IsoId=P07101-2; Sequence=VSP_000543; Name=2; Synonyms=HTH-1, hTH-Delta1b,2, TH type 1; IsoId=P07101-3; Sequence=VSP_000544; Name=4; Synonyms=hTH-Delta2, TH type 2; IsoId=P07101-4; Sequence=VSP_000541; Name=5; Synonyms=hTH-Delta2,8,9; IsoId=P07101-5; Sequence=VSP_000541, VSP_054338; Note=Lacks catalytic activity.; Name=6; Synonyms=hTH-Delta1b,2,8,9; IsoId=P07101-6; Sequence=VSP_000544, VSP_054338; Note=Lacks catalytic activity.; 


uniprotID: P19971
geneSymbol: TYMP
reactome: R-HSA-73614;R-HSA-73621;
pdb: 1UOU;2J0F;2WK5;2WK6;
length: 482
go: ENSG00000025708;
drug: DB01101;DB00369;DB00322;DB00544;DB09343;DB00432;
snps: rs28931613 rs121913037 rs121913038 rs149977726 rs121913036 rs11479
name:
Thymidine phosphorylase (TP) (EC 2.4.2.4) (Gliostatin) (Platelet-derived endothelial cell growth factor) (PD-ECGF) (TdRPase)

sequence:

opentargets:
cytosol [GO:0005829]; growth factor activity [GO:0008083]; phosphorylase activity [GO:0004645]; protein homodimerization activity [GO:0042803]; pyrimidine-nucleoside phosphorylase activity [GO:0016154]; thymidine phosphorylase activity [GO:0009032]; transferase activity, transferring pentosyl groups [GO:0016763]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; mitochondrial genome maintenance [GO:0000002]; pyrimidine nucleobase metabolic process [GO:0006206]; pyrimidine nucleoside catabolic process [GO:0046135]; pyrimidine nucleoside metabolic process [GO:0006213]; pyrimidine nucleoside salvage [GO:0043097]; regulation of gastric motility [GO:1905333]; regulation of myelination [GO:0031641]; regulation of transmission of nerve impulse [GO:0051969]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P19971-1; Sequence=Displayed; Name=2; IsoId=P19971-2; Sequence=VSP_045556; Note=No experimental confirmation available.; 


uniprotID: O75643
geneSymbol: SNRNP200
reactome: R-HSA-72163;R-HSA-72165;
pdb: 2Q0Z;3JCR;4F91;4F92;4F93;4KIT;5O9Z;5URJ;5URK;5URM;5XJC;5YZG;5Z56;5Z57;5Z58;
length: 2136
go: ENSG00000144028;
snps: rs959069360 rs527236113 rs527236114 rs397514575 rs267607077 rs397514574 rs749546665 rs201691299
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9539711}.
name:
U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; post-mRNA release spliceosomal complex [GO:0071014]; spliceosomal complex [GO:0005681]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; ATP binding [GO:0005524]; ATP-dependent helicase activity [GO:0008026]; ATP-dependent RNA helicase activity [GO:0004004]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; cis assembly of pre-catalytic spliceosome [GO:0000354]; mRNA splicing, via spliceosome [GO:0000398]; osteoblast differentiation [GO:0001649]; spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [GO:0000388]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75643-1; Sequence=Displayed; Name=2; IsoId=O75643-2; Sequence=VSP_026622; Note=No experimental confirmation available.; 


uniprotID: C9J2P7
geneSymbol: USP17L15
reactome: R-HSA-5689880;
name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 15 (EC 3.4.19.12)
length: 530
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
sequence:


uniprotID: P61077
geneSymbol: UBE2D3
pdb: 1X23;2FUH;3L1Z;3RPG;3UGB;4BVU;4R8P;4S3O;5EGG;5IFR;6CP0;
length: 147
go: ENSG00000109332;
reactome:
R-HSA-1234176;R-HSA-168927;R-HSA-201451;R-HSA-2173795;R-HSA-8866654;R-HSA-8951664;R-HSA-9033241;R-HSA-936440;R-HSA-937041;R-HSA-983168;

name:
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)

sequence:
MALKRINKELSDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDRDKYNRISREWTQKYAM

opentargets:
cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cellular protein modification process [GO:0006464]; DNA repair [GO:0006281]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein targeting to mitochondrion [GO:1903955]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P61077-1; Sequence=Displayed; Name=2; IsoId=P61077-2; Sequence=VSP_038097; Name=3; IsoId=P61077-3; Sequence=VSP_038096; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}. Endosome membrane {ECO:0000269|PubMed:18508924}; Peripheral membrane protein {ECO:0000269|PubMed:18508924}.


uniprotID: Q16222
geneSymbol: UAP1
reactome: R-HSA-446210;
pdb: 1JV1;1JV3;1JVD;1JVG;
length: 522
go: ENSG00000117143;
drug: DB02196;DB03397;
snps: rs1128539
name:
UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)]

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; UDP-N-acetylglucosamine diphosphorylase activity [GO:0003977]; UDP-N-acetylglucosamine biosynthetic process [GO:0006048]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=AGX2; Synonyms=AGX-2; IsoId=Q16222-1; Sequence=Displayed; Name=AGX1; Synonyms=AGX-1; IsoId=Q16222-2; Sequence=VSP_004483; Name=3; IsoId=Q16222-3; Sequence=VSP_014523; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.


uniprotID: Q96Q05
geneSymbol: TRAPPC9
reactome: R-HSA-204005;R-HSA-8876198;
length: 1148
go: ENSG00000167632;
name:
Trafficking protein particle complex subunit 9 (NIK- and IKBKB-binding protein) (Tularik gene 1 protein)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; trans-Golgi network [GO:0005802]; TRAPP complex [GO:0030008]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; cerebral cortex development [GO:0021987]; COPII vesicle coating [GO:0048208]; neuron differentiation [GO:0030182]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96Q05-1; Sequence=Displayed; Name=2; IsoId=Q96Q05-2; Sequence=VSP_034349; Note=No experimental confirmation available.; Name=3; IsoId=Q96Q05-3; Sequence=VSP_034350; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Processes and cell bodies of neurons. {ECO:0000250}.


uniprotID: Q5GJ75
geneSymbol: TNFAIP8L3
reactome: R-HSA-1483255;
pdb: 4Q9V;
length: 292
go: ENSG00000183578;
snps: rs17647084
name:
Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transporter activity [GO:0008526]; inositol lipid-mediated signaling [GO:0048017]; phospholipid metabolic process [GO:0006644]; phospholipid transport [GO:0015914]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of apoptotic process [GO:0042981]; regulation of lipid metabolic process [GO:0019216]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25479791}. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000250|UniProtKB:Q3TBL6}.


uniprotID: P07951
geneSymbol: TPM2
reactome: R-HSA-390522;R-HSA-445355;
name: Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)
length: 284
go: ENSG00000198467;
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of ATPase activity [GO:0043462]

snps:
rs199476145 rs137853306 rs104894127 rs727504180 rs199476151 rs104894129 rs199476152 rs137853305 rs104894128 rs137853307 rs3180843 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Skeletal muscle; IsoId=P07951-1; Sequence=Displayed; Name=2; Synonyms=non-muscle, Fibroblast TM36, Epithelial TMe1; IsoId=P07951-2; Sequence=VSP_006595, VSP_006596; Name=3; Synonyms=non-muscle; IsoId=P07951-3; Sequence=VSP_006594, VSP_006595, VSP_006596; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775}.


uniprotID: Q9UI30
geneSymbol: TRMT112
reactome: R-HSA-156581;R-HSA-6782315;R-HSA-6790901;R-HSA-72764;
pdb: 6G4W;
name: Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog)
length: 125
go: ENSG00000173113;
sequence:
MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; protein heterodimerization activity [GO:0046982]; protein methyltransferase activity [GO:0008276]; peptidyl-glutamine methylation [GO:0018364]; positive regulation of rRNA processing [GO:2000234]; rRNA (guanine-N7)-methylation [GO:0070476]; tRNA methylation [GO:0030488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UI30-1; Sequence=Displayed; Name=2; IsoId=Q9UI30-2; Sequence=VSP_054748; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25851604}. Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604). {ECO:0000269|PubMed:25851604}.


uniprotID: Q5T6R2
geneSymbol: TPTE2P1
name: Putative phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2P1
length: 138
sequence:
MPAAFPCVFPPQSLQVFPQMIVKVWEKQSLPLPGLRGSPVERLYLPRNELDNPHKQKAWKIYPPEFAVEILFGMVSVDSLLFVLSSPHWWLHLAQGSFWMSEGGFSLCHPGWSVVAQSLLTSTSAFCVRAILLPQPPE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T6R2-1; Sequence=Displayed; Name=2; IsoId=Q5T6R2-2; Sequence=VSP_033857; 


uniprotID: Q13077
geneSymbol: TRAF1
reactome: R-HSA-5357905;R-HSA-5357956;
pdb: 3M0D;5E1T;5H10;
name: TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
length: 416
go: ENSG00000056558;
snps: rs113495277
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-containing complex assembly [GO:0065003]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13077-1; Sequence=Displayed; Name=2; IsoId=Q13077-2; Sequence=VSP_043092; Note=No experimental confirmation available.; 


uniprotID: Q15629
geneSymbol: TRAM1
reactome: R-HSA-1799339;
name: Translocating chain-associated membrane protein 1
length: 374
go: ENSG00000067167;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of membrane [GO:0016021]; rough endoplasmic reticulum [GO:0005791]; signaling receptor activity [GO:0038023]; cotranslational protein targeting to membrane [GO:0006613]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15629-1; Sequence=Displayed; Name=2; IsoId=Q15629-2; Sequence=VSP_056213; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1315422}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9UBP6
geneSymbol: METTL1
reactome: R-HSA-6782315;
pdb: 3CKK;
length: 276
go: ENSG00000037897;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:15861136}.
name:
tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase)

sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]; tRNA (guanine-N7-)-methyltransferase activity [GO:0008176]; tRNA binding [GO:0000049]; RNA (guanine-N7)-methylation [GO:0036265]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UBP6-1; Sequence=Displayed; Name=2; IsoId=Q9UBP6-2; Sequence=VSP_044671, VSP_044672; Note=No experimental confirmation available.; 


uniprotID: Q9BYJ4
geneSymbol: TRIM34
reactome: R-HSA-877300;
pdb: 2EGP;
length: 488
go: ENSG00000258659;
snps: rs6578670 rs3740997 rs16933844
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811}.
name:
Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; interferon-gamma-mediated signaling pathway [GO:0060333]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; protein trimerization [GO:0070206]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Medium; IsoId=Q9BYJ4-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9BYJ4-2; Sequence=VSP_011921, VSP_011922; 


uniprotID: Q7RTX1
geneSymbol: TAS1R1
reactome: R-HSA-418594;R-HSA-420499;
name: Taste receptor type 1 member 1 (G-protein coupled receptor 70)
length: 841
go: ENSG00000173662;
snps: rs10864628 rs34160967 rs35118458
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; protein heterodimerization activity [GO:0046982]; taste receptor activity [GO:0008527]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of umami taste [GO:0050917]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Gm148 form B; IsoId=Q7RTX1-1; Sequence=Displayed; Name=2; Synonyms=Gm148 form C; IsoId=Q7RTX1-2; Sequence=VSP_012418; Note=No experimental confirmation available.; Name=3; Synonyms=Gm148 form A; IsoId=Q7RTX1-3; Sequence=VSP_012418, VSP_012420; Note=No experimental confirmation available. {ECO:0000305}; Name=4; Synonyms=Gm148 form D; IsoId=Q7RTX1-4; Sequence=VSP_012418, VSP_012421, VSP_012422; Note=Incomplete sequence.; 


uniprotID: Q15631
geneSymbol: TSN
reactome: R-HSA-426486;
pdb: 1J1J;3PJA;3QB5;4WYV;
name: Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO)
length: 228
go: ENSG00000211460;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; DNA recombination [GO:0006310]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15631-1; Sequence=Displayed; Name=2; IsoId=Q15631-2; Sequence=VSP_044937, VSP_044938; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11801738}. Nucleus {ECO:0000269|PubMed:11801738}.


uniprotID: Q5TAA0
geneSymbol: TTC22
name: Tetratricopeptide repeat protein 22 (TPR repeat protein 22)
length: 569
go: ENSG00000006555;
snps: rs671108
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TAA0-1; Sequence=Displayed; Name=2; IsoId=Q5TAA0-2; Sequence=VSP_021859, VSP_021860; Note=No experimental confirmation available.; 


uniprotID: A2A3L6
geneSymbol: TTC24
name: Tetratricopeptide repeat protein 24 (TPR repeat protein 24)
length: 582
go: ENSG00000187862;
snps: rs6682716 rs17392348 rs12090808
sequence:


uniprotID: Q8N4P2
geneSymbol: TTC30B
reactome: R-HSA-5620924;
name: Tetratricopeptide repeat protein 30B (TPR repeat protein 30B)
length: 665
go: ENSG00000196659;
snps: rs11694988 rs2695315
location: SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
sequence:

opentargets:
ciliary tip [GO:0097542]; cilium [GO:0005929]; intraciliary transport particle B [GO:0030992]; intraciliary transport [GO:0042073]; intraciliary transport involved in cilium assembly [GO:0035735]


uniprotID: Q9ULT0
geneSymbol: TTC7A
name: Tetratricopeptide repeat protein 7A (TPR repeat protein 7A)
length: 858
go: ENSG00000068724;
snps: rs147914967 rs2304290 rs776906926 rs6755258 rs139010200 rs149602485 rs587776972 rs876657393
sequence:

opentargets:
cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; cellular iron ion homeostasis [GO:0006879]; hemopoiesis [GO:0030097]; phosphatidylinositol phosphorylation [GO:0046854]; protein localization to plasma membrane [GO:0072659]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9ULT0-1; Sequence=Displayed; Name=2; IsoId=Q9ULT0-3; Sequence=VSP_039347, VSP_039348; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q9ULT0-4; Sequence=VSP_057271; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25546680}. Cell membrane {ECO:0000250|UniProtKB:Q86TV6}. Note=Localizes to the cytosol and is recruited to the plasma membrane following interaction with EFR3 (EFR3A or EFR3B). {ECO:0000250|UniProtKB:Q86TV6}.


uniprotID: Q5TCY1
geneSymbol: TTBK1
pdb: 4BTJ;4BTK;4BTM;4NFM;4NFN;
name: Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)
length: 1321
go: ENSG00000146216;
snps: rs34993661 rs3800294 rs35175743 rs56377340 rs3800295 rs267601046 rs3800297 rs3800298
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16923168}.
sequence:

opentargets:
cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; learning or memory [GO:0007611]; negative regulation of gene expression [GO:0010629]; negative regulation of protein binding [GO:0032091]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of cyclin-dependent protein kinase activity [GO:1904031]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of protein polymerization [GO:0032273]; protein phosphorylation [GO:0006468]; substantia nigra development [GO:0021762]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TCY1-1; Sequence=Displayed; Name=2; IsoId=Q5TCY1-2; Sequence=VSP_026497, VSP_026498, VSP_026499; Note=No experimental confirmation available.; 


uniprotID: Q01534
geneSymbol: TSPY1
name: Testis-specific Y-encoded protein 1 (Cancer/testis antigen 78) (CT78)
length: 308
go: ENSG00000258992;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; sex differentiation [GO:0007548]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Short, TSPY-S; IsoId=Q01534-1; Sequence=Displayed; Name=2; Synonyms=Long, TSPY-L; IsoId=Q01534-2; Sequence=VSP_008012; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8923009}. Nucleus {ECO:0000269|PubMed:8923009}. Note=Predominantly cytoplasmic. Also found in nucleus.


uniprotID: Q8NA56
geneSymbol: TTC29
length: 475
go: ENSG00000137473;
snps: rs35123039 rs17610219 rs10013280
name:
Tetratricopeptide repeat protein 29 (TPR repeat protein 29) (Protein TBPP2A) (Testis development protein NYD-SP14)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NA56-1; Sequence=Displayed; Name=2; IsoId=Q8NA56-2; Sequence=VSP_026638; Note=No experimental confirmation available.; 


uniprotID: Q6PID6
geneSymbol: TTC33
name: Tetratricopeptide repeat protein 33 (TPR repeat protein 33) (Osmosis-responsive factor)
length: 262
go: ENSG00000113638;
snps: rs837105
sequence:


uniprotID: Q13432
geneSymbol: UNC119
pdb: 3GQQ;3RBQ;4GOJ;4GOK;5L7K;6H6A;
name: Protein unc-119 homolog A (Retinal protein 4) (hRG4)
length: 240
go: ENSG00000109103;
snps: rs199714731
sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; lipid binding [GO:0008289]; chemical synaptic transmission [GO:0007268]; endocytosis [GO:0006897]; lipoprotein transport [GO:0042953]; mitotic cytokinesis [GO:0000281]; negative regulation of caveolin-mediated endocytosis [GO:2001287]; negative regulation of clathrin-dependent endocytosis [GO:1900186]; nervous system development [GO:0007399]; phototransduction [GO:0007602]; positive regulation of protein tyrosine kinase activity [GO:0061098]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=A; IsoId=Q13432-1; Sequence=Displayed; Name=B; IsoId=Q13432-2; Sequence=VSP_004545; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:23535298}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23535298}. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells. {ECO:0000269|PubMed:23535298}.


uniprotID: A6NIH7
geneSymbol: UNC119B
reactome: R-HSA-5624138;
name: Protein unc-119 homolog B
length: 251
go: ENSG00000175970;
sequence:

opentargets:
ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytosol [GO:0005829]; lipid binding [GO:0008289]; cilium assembly [GO:0060271]; lipoprotein transport [GO:0042953]; nervous system development [GO:0007399]

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:22085962}. Note=Enriched at the transition zone and extended into the proximal end of the cilium.


uniprotID: O95164
geneSymbol: UBL3
pdb: 2GOW;
name: Ubiquitin-like protein 3 (Membrane-anchored ubiquitin-fold protein) (HsMUB) (MUB) (Protein HCG-1)
length: 117
go: ENSG00000122042;
opentargets: extracellular exosome [GO:0070062]; intracellular [GO:0005622]; plasma membrane [GO:0005886]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
sequence:
MSSNVPADMINLRLILVSGKTKEFLFSPNDSASDIAKHVYDNWPMDWEEEQVSSPNILRLIYQGRFLHGNVTLGALKLPFGKTTVMHLVARETLPEPNSQGQRNREKTGESNCCVIL


uniprotID: Q9Y5T5
geneSymbol: USP16
reactome: R-HSA-5689880;
pdb: 2I50;
length: 823
go: ENSG00000156256;
snps: rs2274802
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17914355}.
name:
Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transcription coactivator activity [GO:0003713]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; histone deubiquitination [GO:0016578]; histone H2A K63-linked deubiquitination [GO:0070537]; mitotic cell cycle [GO:0000278]; mitotic nuclear division [GO:0140014]; monoubiquitinated histone H2A deubiquitination [GO:0035522]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of translational elongation [GO:0045901]; protein deubiquitination [GO:0016579]; protein homotetramerization [GO:0051289]; regulation of cell cycle [GO:0051726]; regulation of transcription by RNA polymerase II [GO:0006357]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9Y5T5-1; Sequence=Displayed; Name=2; IsoId=Q9Y5T5-2; Sequence=VSP_036715; Name=3; IsoId=Q9Y5T5-3; Sequence=VSP_036714, VSP_036715; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y5T5-4; Sequence=VSP_036713; Note=No experimental confirmation available.; Name=5; IsoId=Q9Y5T5-5; Sequence=VSP_036716; 


uniprotID: Q8TEY7
geneSymbol: USP33
reactome: R-HSA-5689880;R-HSA-9010553;
pdb: 2UZG;
length: 942
go: ENSG00000077254;
name:
Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)

sequence:

opentargets:
cell body [GO:0044297]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; VCB complex [GO:0030891]; cysteine-type endopeptidase activity [GO:0004197]; G protein-coupled receptor binding [GO:0001664]; Ral GTPase binding [GO:0017160]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; zinc ion binding [GO:0008270]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cellular response to starvation [GO:0009267]; centrosome duplication [GO:0051298]; endocytosis [GO:0006897]; negative regulation of protein binding [GO:0032091]; positive regulation of protein binding [GO:0032092]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TEY7-1; Sequence=Displayed; Name=2; IsoId=Q8TEY7-2; Sequence=VSP_008591; Name=3; IsoId=Q8TEY7-3; Sequence=VSP_008592, VSP_008593, VSP_008594; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19118533}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23486064}. Note=Associates with centrosomes predominantly in S and G2 phases but less in G1 phase (PubMed:23486064). {ECO:0000269|PubMed:23486064}.; SUBCELLULAR LOCATION: Isoform 3: Golgi apparatus {ECO:0000269|PubMed:21801292}.


uniprotID: Q9P275
geneSymbol: USP36
length: 1123
go: ENSG00000055483;
snps: rs3744793 rs3744795 rs9889908 rs3088040 rs3744797 rs1057040 rs61760231 rs866027510
name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.4.19.12) (Deubiquitinating enzyme 36) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; cysteine-type endopeptidase activity [GO:0004197]; RNA binding [GO:0003723]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; histone deubiquitination [GO:0016578]; negative regulation of macroautophagy [GO:0016242]; nucleolus organization [GO:0007000]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of protein stability [GO:0031647]; regulation of rRNA processing [GO:2000232]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19208757, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:27445338}. Cytoplasm {ECO:0000269|PubMed:27445338}.


uniprotID: O94782
geneSymbol: USP1
reactome: R-HSA-110314;R-HSA-6783310;
length: 785
go: ENSG00000162607;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15694335}.
name:
Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; monoubiquitinated protein deubiquitination [GO:0035520]; protein deubiquitination [GO:0016579]; regulation of DNA repair [GO:0006282]; response to UV [GO:0009411]; skeletal system development [GO:0001501]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: P62068
geneSymbol: USP46
pdb: 5CVM;5CVN;5CVO;5L8H;
length: 366
go: ENSG00000109189;
snps: rs17475800
name:
Ubiquitin carboxyl-terminal hydrolase 46 (EC 3.4.19.12) (Deubiquitinating enzyme 46) (Ubiquitin thioesterase 46) (Ubiquitin-specific-processing protease 46)

sequence:

opentargets:
glutamatergic synapse [GO:0098978]; cysteine-type endopeptidase activity [GO:0004197]; metal ion binding [GO:0046872]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; adult feeding behavior [GO:0008343]; behavioral fear response [GO:0001662]; behavioral response to ethanol [GO:0048149]; protein deubiquitination [GO:0016579]; regulation of postsynaptic neurotransmitter receptor internalization [GO:0099149]; regulation of synaptic transmission, GABAergic [GO:0032228]; righting reflex [GO:0060013]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P62068-1; Sequence=Displayed; Name=2; IsoId=P62068-2; Sequence=VSP_037618, VSP_037621; Note=No experimental confirmation available.; Name=3; IsoId=P62068-3; Sequence=VSP_037619; Note=No experimental confirmation available.; Name=4; IsoId=P62068-4; Sequence=VSP_037620; Note=No experimental confirmation available.; 


uniprotID: Q8NB14
geneSymbol: USP38
pdb: 4RXX;
length: 1042
go: ENSG00000170185;
name:
Ubiquitin carboxyl-terminal hydrolase 38 (EC 3.4.19.12) (Deubiquitinating enzyme 38) (HP43.8KD) (Ubiquitin thioesterase 38) (Ubiquitin-specific-processing protease 38)

sequence:

opentargets:
cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NB14-1; Sequence=Displayed; Name=2; IsoId=Q8NB14-2; Sequence=VSP_054486; Note=No experimental confirmation available.; 


uniprotID: Q9NVE5
geneSymbol: USP40
length: 1235
go: ENSG00000085982;
snps: rs838543 rs34026756 rs1048603
name:
Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.4.19.12) (Deubiquitinating enzyme 40) (Ubiquitin thioesterase 40) (Ubiquitin-specific-processing protease 40)

sequence:

opentargets:
cytosol [GO:0005829]; cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; protein deubiquitination [GO:0016579]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NVE5-1; Sequence=Displayed; Name=2; IsoId=Q9NVE5-2; Sequence=VSP_008595, VSP_008596, VSP_012819; Note=No experimental confirmation available.; Name=3; IsoId=Q9NVE5-3; Sequence=VSP_040938; 


uniprotID: Q86UV5
geneSymbol: USP48
reactome: R-HSA-5689880;
length: 1035
go: ENSG00000090686;
snps: rs4253886 rs12097805
name:
Ubiquitin carboxyl-terminal hydrolase 48 (EC 3.4.19.12) (Deubiquitinating enzyme 48) (Ubiquitin thioesterase 48) (Ubiquitin-specific peptidase 48) (Ubiquitin-specific protease 48) (Ubiquitin-specific-processing protease 48)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q86UV5-1; Sequence=Displayed; Name=2; IsoId=Q86UV5-2; Sequence=VSP_020480; Note=No experimental confirmation available.; Name=3; IsoId=Q86UV5-3; Sequence=VSP_020479; Note=No experimental confirmation available.; Name=4; IsoId=Q86UV5-4; Sequence=VSP_020473, VSP_020474; Note=No experimental confirmation available.; Name=5; IsoId=Q86UV5-5; Sequence=VSP_020472, VSP_020475, VSP_020478, VSP_020480; Note=No experimental confirmation available. {ECO:0000305}; Name=6; IsoId=Q86UV5-6; Sequence=VSP_020471, VSP_020481; Note=No experimental confirmation available.; Name=7; Synonyms=USP31S1; IsoId=Q86UV5-7; Sequence=VSP_020476, VSP_020477; Name=8; IsoId=Q86UV5-8; Sequence=VSP_054487, VSP_054488; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16214042}. Nucleus {ECO:0000269|PubMed:16214042}.


uniprotID: P40818
geneSymbol: USP8
reactome: R-HSA-1358803;R-HSA-4641263;R-HSA-5689880;R-HSA-6807004;
pdb: 1WHB;2A9U;2GFO;2GWF;3N3K;6F09;
length: 1118
go: ENSG00000138592;
snps: rs587777201 rs3743044 rs672601308 rs672601307 rs672601311 rs11638390 rs1056577
name:
Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; early endosome [GO:0005769]; extrinsic component of endosome membrane [GO:0031313]; extrinsic component of plasma membrane [GO:0019897]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; cysteine-type endopeptidase activity [GO:0004197]; SH3 domain binding [GO:0017124]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; cell proliferation [GO:0008283]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to nerve growth factor stimulus [GO:1990090]; endosome organization [GO:0007032]; mitotic cytokinesis [GO:0000281]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P40818-1; Sequence=Displayed; Name=2; IsoId=P40818-2; Sequence=VSP_054594, VSP_054595; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858, ECO:0000269|PubMed:19427866, ECO:0000269|PubMed:28505279}. Nucleus {ECO:0000250|UniProtKB:Q80U87}. Endosome membrane {ECO:0000269|PubMed:16520378, ECO:0000269|PubMed:17711858}; Peripheral membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:16520378}; Peripheral membrane protein {ECO:0000305}.


uniprotID: Q70CQ1
geneSymbol: USP49
reactome: R-HSA-5689880;
length: 688
go: ENSG00000164663;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:23824326}.
name:
Ubiquitin carboxyl-terminal hydrolase 49 (EC 3.4.19.12) (Deubiquitinating enzyme 49) (Ubiquitin thioesterase 49) (Ubiquitin-specific-processing protease 49)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; cysteine-type endopeptidase activity [GO:0004197]; histone binding [GO:0042393]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; zinc ion binding [GO:0008270]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; mRNA splicing, via spliceosome [GO:0000398]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q70CQ1-1; Sequence=Displayed; Name=2; IsoId=Q70CQ1-2; Sequence=VSP_011556; Note=No experimental confirmation available.; 


uniprotID: Q70EL4
geneSymbol: USP43
reactome: R-HSA-5656169;
length: 1123
go: ENSG00000154914;
name:
Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43)

sequence:

opentargets:
nucleoplasm [GO:0005654]; ISG15-specific protease activity [GO:0019785]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; protein deubiquitination [GO:0016579]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q70EL4-1; Sequence=Displayed; Name=2; IsoId=Q70EL4-2; Sequence=VSP_020466, VSP_020468; Note=No experimental confirmation available.; Name=3; IsoId=Q70EL4-3; Sequence=VSP_020467; Note=No experimental confirmation available.; Name=4; IsoId=Q70EL4-4; Sequence=VSP_046779; Note=No experimental confirmation available.; 


uniprotID: O95071
geneSymbol: UBR5
pdb: 1I2T;2QHO;3PT3;
length: 2799
go: ENSG00000104517;
snps: rs1062822
location: SUBCELLULAR LOCATION: Nucleus.
name:
E3 ubiquitin-protein ligase UBR5 (EC 2.3.2.26) (E3 ubiquitin-protein ligase, HECT domain-containing 1) (HECT-type E3 ubiquitin transferase UBR5) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; zinc ion binding [GO:0008270]; cell proliferation [GO:0008283]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of gene expression [GO:0010628]; positive regulation of protein import into nucleus, translocation [GO:0033160]; progesterone receptor signaling pathway [GO:0050847]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95071-1; Sequence=Displayed; Name=2; IsoId=O95071-2; Sequence=VSP_054399; Note=No experimental confirmation available.; 


uniprotID: P57075
geneSymbol: UBASH3A
pdb: 2CRN;5WDI;
length: 661
go: ENSG00000160185;
snps: rs2277798 rs2277800 rs775952011 rs13048049 rs13048049 rs17114930
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
name:
Ubiquitin-associated and SH3 domain-containing protein A (Cbl-interacting protein 4) (CLIP4) (Suppressor of T-cell receptor signaling 2) (STS-2) (T-cell ubiquitin ligand 1) (TULA-1)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; phosphatase activity [GO:0016791]; negative regulation of signal transduction [GO:0009968]; negative regulation of T cell receptor signaling pathway [GO:0050860]; regulation of cytokine production [GO:0001817]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Long; IsoId=P57075-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P57075-2; Sequence=VSP_006703; Name=3; IsoId=P57075-3; Sequence=VSP_006703, VSP_045549, VSP_045550; Note=No experimental confirmation available.; 


uniprotID: Q8TF42
geneSymbol: UBASH3B
pdb: 2CPW;2E5K;5VR6;5W5G;
length: 649
go: ENSG00000154127;
snps: rs12790613 rs35343548
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
name:
Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; phosphatase activity [GO:0016791]; phosphoprotein binding [GO:0051219]; protein tyrosine phosphatase activity [GO:0004725]; ubiquitin protein ligase binding [GO:0031625]; collagen-activated signaling pathway [GO:0038065]; collagen-activated tyrosine kinase receptor signaling pathway [GO:0038063]; negative regulation of bone resorption [GO:0045779]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of platelet aggregation [GO:0090331]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet aggregation [GO:0070527]; regulation of osteoclast differentiation [GO:0045670]; regulation of protein binding [GO:0043393]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]


uniprotID: Q96LJ8
geneSymbol: UBXN10
name: UBX domain-containing protein 10 (UBX domain-containing protein 3)
length: 280
go: ENSG00000162543;
opentargets: cilium [GO:0005929]; cilium assembly [GO:0060271]
sequence:

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:26389662}. Note=Recruited to cilia in a VCP-dependent manner. {ECO:0000269|PubMed:26389662}.


uniprotID: Q8IWV8
geneSymbol: UBR2
reactome: R-HSA-983168;
pdb: 3NY2;3NY3;5TDA;5TDB;5TDD;5UM3;
length: 1755
go: ENSG00000024048;
snps: rs6905054 rs6917033 rs6917033 rs6917033
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associated with chromatin during meiosis.
name:
E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)

sequence:

opentargets:
chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; leucine binding [GO:0070728]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cellular response to leucine [GO:0071233]; chromatin silencing [GO:0006342]; histone H2A ubiquitination [GO:0033522]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; negative regulation of TOR signaling [GO:0032007]; negative regulation of transposition [GO:0010529]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; ubiquitin-dependent protein catabolic process via the N-end rule pathway [GO:0071596]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8IWV8-1; Sequence=Displayed; Name=2; IsoId=Q8IWV8-2; Sequence=VSP_015167, VSP_015168; Name=3; IsoId=Q8IWV8-3; Sequence=VSP_015166, VSP_015169, VSP_015170, VSP_015171; Note=No experimental confirmation available.; Name=4; IsoId=Q8IWV8-4; Sequence=VSP_017130; Note=Derived from mouse cDNA data. No experimental confirmation available.; 


uniprotID: P25874
geneSymbol: UCP1
reactome: R-HSA-167826;R-HSA-167827;
length: 307
go: ENSG00000109424;
snps: rs45539933 rs2270565
name:
Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; cardiolipin binding [GO:1901612]; long-chain fatty acid binding [GO:0036041]; oxidative phosphorylation uncoupler activity [GO:0017077]; purine ribonucleotide binding [GO:0032555]; transmembrane transporter activity [GO:0022857]; adaptive thermogenesis [GO:1990845]; brown fat cell differentiation [GO:0050873]; cellular response to fatty acid [GO:0071398]; cellular response to hormone stimulus [GO:0032870]; cellular response to reactive oxygen species [GO:0034614]; diet induced thermogenesis [GO:0002024]; mitochondrial transmembrane transport [GO:1990542]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; regulation of reactive oxygen species biosynthetic process [GO:1903426]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cold [GO:0009409]; response to nutrient levels [GO:0031667]; response to temperature stimulus [GO:0009266]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P12242}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P04633}.


uniprotID: P55851
geneSymbol: UCP2
reactome: R-HSA-167826;R-HSA-167827;
name: Mitochondrial uncoupling protein 2 (UCP 2) (Solute carrier family 25 member 8) (UCPH)
length: 309
go: ENSG00000175567;
snps: rs660339 rs45541732 rs45486692 rs45490393 rs45596837
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; oxidative phosphorylation uncoupler activity [GO:0017077]; adaptive thermogenesis [GO:1990845]; aging [GO:0007568]; cellular response to amino acid starvation [GO:0034198]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; female pregnancy [GO:0007565]; liver regeneration [GO:0097421]; mitochondrial transmembrane transport [GO:1990542]; negative regulation of apoptotic process [GO:0043066]; negative regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061179]; positive regulation of cell death [GO:0010942]; positive regulation of cold-induced thermogenesis [GO:0120162]; proton transmembrane transport [GO:1902600]; regulation of mitochondrial membrane potential [GO:0051881]; response to cold [GO:0009409]; response to fatty acid [GO:0070542]; response to hypoxia [GO:0001666]; response to superoxide [GO:0000303]


uniprotID: Q9HAW7
geneSymbol: UGT1A7
reactome: R-HSA-156588;
length: 530
go: ENSG00000244122;
drug: DB00688;DB01024;DB00197;
snps: rs17868323 rs386656364 rs17868324 rs11692021
name:
UDP-glucuronosyltransferase 1-7 (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) (UDP-glucuronosyltransferase 1A7)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; drug binding [GO:0008144]; enzyme binding [GO:0019899]; enzyme inhibitor activity [GO:0004857]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; retinoic acid binding [GO:0001972]; UDP-glycosyltransferase activity [GO:0008194]; cellular glucuronidation [GO:0052695]; coumarin metabolic process [GO:0009804]; drug metabolic process [GO:0017144]; excretion [GO:0007588]; fatty acid metabolic process [GO:0006631]; flavone metabolic process [GO:0051552]; flavonoid glucuronidation [GO:0052696]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; retinoic acid metabolic process [GO:0042573]; xenobiotic glucuronidation [GO:0052697]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=i1; IsoId=Q9HAW7-1; Sequence=Displayed; Name=2; Synonyms=i2, UGT1A7s; IsoId=Q9HAW7-2; Sequence=VSP_053963; 


uniprotID: P98066
geneSymbol: TNFAIP6
reactome: R-HSA-6798695;
pdb: 1O7B;1O7C;2N40;2PF5;2WNO;
length: 277
go: ENSG00000123610;
drug: DB08818;
snps: rs1046668
name:
Tumor necrosis factor-inducible gene 6 protein (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule lumen [GO:1904813]; tertiary granule lumen [GO:1904724]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; inflammatory response [GO:0006954]; negative regulation of inflammatory response [GO:0050728]; neutrophil degranulation [GO:0043312]; ovulation [GO:0030728]; positive regulation of cell migration [GO:0030335]; signal transduction [GO:0007165]


uniprotID: P49815
geneSymbol: TSC2
reactome: R-HSA-1632852;R-HSA-165181;R-HSA-198323;R-HSA-380972;R-HSA-5628897;R-HSA-5674400;R-HSA-8854214;
name: Tuberin (Tuberous sclerosis 2 protein)
length: 1807
go: ENSG00000103197;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; lysosome [GO:0005764]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; TSC1-TSC2 complex [GO:0033596]; GTPase activator activity [GO:0005096]; Hsp90 protein binding [GO:0051879]; phosphatase binding [GO:0019902]; protein homodimerization activity [GO:0042803]; small GTPase binding [GO:0031267]; anoikis [GO:0043276]; endocytosis [GO:0006897]; heart development [GO:0007507]; insulin-like growth factor receptor signaling pathway [GO:0048009]; negative regulation of cell proliferation [GO:0008285]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of mitophagy [GO:1901525]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of Wnt signaling pathway [GO:0030178]; neural tube closure [GO:0001843]; positive chemotaxis [GO:0050918]; positive regulation of macroautophagy [GO:0016239]; protein import into nucleus [GO:0006606]; protein kinase B signaling [GO:0043491]; protein localization [GO:0008104]; regulation of cell cycle [GO:0051726]; regulation of endocytosis [GO:0030100]; regulation of insulin receptor signaling pathway [GO:0046626]; regulation of small GTPase mediated signal transduction [GO:0051056]; vesicle-mediated transport [GO:0016192]; viral process [GO:0016032]

snps:
rs1051616 rs45517107 rs45517109 rs45517122 rs137854875 rs45502703 rs45517130 rs45517136 rs1800748 rs45517138 rs45487497 rs137853986 rs1131825 rs45517153 rs45517147 rs1800725 rs45517154 rs45517156 rs45484298 rs45443091 rs45517171 rs45486599 rs45517175 rs45457694 rs45517187 rs1800729 rs45517198 rs45517202 rs45517203 rs28934872 rs45469298 rs45454398 rs45481105 rs1131826 rs45509392 rs45486196 rs45517214 rs45499191 rs1051621 rs45517236 rs45517238 rs45517249 rs45470695 rs45517259 rs45517258 rs45517275 rs45438192 rs45517286 rs34870424 rs45517294 rs45438205 rs45446700 rs397514916 rs45517323 rs45462593 rs45474795 rs45517338 rs45497997 rs137854879 rs745895675 rs45517355 rs45511204 rs45446901 rs45482398 rs45517380 rs45517381 rs45501091 rs45517382 rs45517383 rs45490993 rs45483392 rs45476793 rs137854882 rs45474691 rs45517393 rs45507199 rs45507199 rs45517413 rs45459299 rs45517418 rs9209 rs45517419 rs45517421 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=P49815-1; Sequence=Displayed; Name=2; IsoId=P49815-2; Sequence=VSP_004470; Note=No experimental confirmation available.; Name=3; IsoId=P49815-3; Sequence=VSP_004471; Note=No experimental confirmation available.; Name=4; IsoId=P49815-4; Sequence=VSP_004472; Name=5; IsoId=P49815-5; Sequence=VSP_004471, VSP_004472; Name=6; IsoId=P49815-6; Sequence=VSP_038355, VSP_004470, VSP_004472; Name=7; IsoId=P49815-7; Sequence=VSP_054163, VSP_004470, VSP_004472; Note=No experimental confirmation available.; Name=8; Synonyms=H, I; IsoId=P49815-8; Sequence=VSP_055896, VSP_055897; Note=May be due to an intron retention.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.


uniprotID: Q6PGP7
geneSymbol: TTC37
reactome: R-HSA-429958;
length: 1564
go: ENSG00000198677;
snps: rs763816083 rs17084873 rs146627706 rs2303650 rs376720108
name:
Tetratricopeptide repeat protein 37 (TPR repeat protein 37) (SKI3 homolog) (Ski3) (Tricho-hepatic-enteric syndrome protein) (Thespin)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]; transcriptionally active chromatin [GO:0035327]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16024656}. Nucleus {ECO:0000269|PubMed:16024656}.


uniprotID: Q5W5X9
geneSymbol: TTC23
length: 447
go: ENSG00000103852;
name:
Tetratricopeptide repeat protein 23 (TPR repeat protein 23) (Cervical cancer proto-oncogene 8 protein) (HCC-8)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5W5X9-1; Sequence=Displayed; Name=2; IsoId=Q5W5X9-2; Sequence=VSP_026017; Name=3; IsoId=Q5W5X9-3; Sequence=VSP_026018; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; 


uniprotID: Q969E8
geneSymbol: TSR2
name: Pre-rRNA-processing protein TSR2 homolog
length: 191
go: ENSG00000158526;
snps: rs786203996
sequence:
MAGAAEDARALFRAGVCAALEAWPALQIAVENGFGGVHSQEKAKWLGGAVEDYFMRNADLELDEVEDFLGELLTNEFDTVVEDGSLPQVSQQLQTMFHHFQRGDGAALREMASCITQRKCKVTATALKTARETDEDEDDVDSVEEMEVTATNDGAATDGVCPQPEPSDPDAQTIKEEDIVEDGWTIVRRKK

opentargets:
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]


uniprotID: Q6P2S7
geneSymbol: TTC41P
length: 1318
opentargets: cytoplasm [GO:0005737]
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Putative tetratricopeptide repeat protein 41 (TPR repeat protein 41) (Grp94-neighboring nucleotidase)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6P2S7-1; Sequence=Displayed; Name=2; IsoId=Q6P2S7-2; Sequence=VSP_034495, VSP_034496; Note=No experimental confirmation available.; Name=3; IsoId=Q6P2S7-3; Sequence=VSP_034494; Note=No experimental confirmation available.; 


uniprotID: Q8WU66
geneSymbol: TSPEAR
name: Thrombospondin-type laminin G domain and EAR repeat-containing protein (TSP-EAR)
length: 669
go: ENSG00000175894;
snps: rs782068174
sequence:

opentargets:
cell surface [GO:0009986]; ciliary membrane [GO:0060170]; extracellular region [GO:0005576]; stereocilium [GO:0032420]; sensory perception of sound [GO:0007605]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WU66-1; Sequence=Displayed; Name=2; IsoId=Q8WU66-2; Sequence=VSP_004006, VSP_004007; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell surface {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Note=Secreted protein which may bind to the cell surface via a membrane receptor. {ECO:0000250}.


uniprotID: Q5I0X7
geneSymbol: TTC32
name: Tetratricopeptide repeat protein 32 (TPR repeat protein 32)
length: 151
go: ENSG00000183891;
sequence:
MEGQRQESHATLTLAQAHFNNGEYAEAEALYSAYIRRCACAASSDESPGSKCSPEDLATAYNNRGQIKYFRVDFYEAMDDYTSAIEVQPNFEVPYYNRGLILYRLGYFDDALEDFKKVLDLNPGFQDATLSLKQTILDKEEKQRRNVAKNY


uniprotID: Q9BSA4
geneSymbol: TTYH2
reactome: R-HSA-2672351;
name: Protein tweety homolog 2 (hTTY2)
length: 534
go: ENSG00000141540;
snps: rs11538875 rs11538876 rs35682745 rs35999669 rs9892705 rs12600564 rs9899862
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
chloride channel complex [GO:0034707]; plasma membrane [GO:0005886]; intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BSA4-1; Sequence=Displayed; Name=2; IsoId=Q9BSA4-2; Sequence=VSP_040567; Note=No experimental confirmation available.; 


uniprotID: Q6NXR4
geneSymbol: TTI2
name: TELO2-interacting protein 2
length: 508
go: ENSG00000129696;
opentargets: ASTRA complex [GO:0070209]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]
snps: rs2304748 rs3736497 rs398122367
sequence:


uniprotID: Q14166
geneSymbol: TTLL12
reactome: R-HSA-8955332;
name: Tubulin--tyrosine ligase-like protein 12
length: 644
go: ENSG00000100304;
opentargets: ATP binding [GO:0005524]; cellular protein modification process [GO:0006464]
snps: rs138951 rs13058467 rs11704935 rs34074034
sequence:


uniprotID: Q6NUM6
geneSymbol: TYW1B
length: 668
go: ENSG00000277149;
name:
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B)

sequence:

opentargets:
4 iron, 4 sulfur cluster binding [GO:0051539]; FMN binding [GO:0010181]; metal ion binding [GO:0046872]; tRNA-4-demethylwyosine synthase activity [GO:0102521]; oxidation-reduction process [GO:0055114]; tRNA processing [GO:0008033]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NUM6-1; Sequence=Displayed; Name=2; IsoId=Q6NUM6-2; Sequence=VSP_056092; Note=No experimental confirmation available.; 


uniprotID: Q15695
geneSymbol: ZRSR2P1
length: 479
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Putative U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 1)

sequence:

opentargets:
spliceosomal complex [GO:0005681]; U2AF [GO:0089701]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; mRNA splicing, via spliceosome [GO:0000398]


uniprotID: Q15696
geneSymbol: ZRSR2
reactome: R-HSA-72165;
length: 482
go: ENSG00000169249;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15146077}.
name:
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)

sequence:

opentargets:
nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U12-type spliceosomal complex [GO:0005689]; U2AF [GO:0089701]; metal ion binding [GO:0046872]; pre-mRNA 3'-splice site binding [GO:0030628]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]


uniprotID: A8MUK1
geneSymbol: USP17L5
reactome: R-HSA-5689880;
length: 530
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 5) (Ubiquitin thioesterase 17-like protein 5) (Ubiquitin-specific-processing protease 17-like protein 5)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; apoptotic process [GO:0006915]; protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q6QN14
geneSymbol: USP17L6P
length: 398
name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 6 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 6) (Ubiquitin thioesterase 17-like protein 6) (Ubiquitin-specific-processing protease 17-like protein 6)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17109758}. Cytoplasm {ECO:0000269|PubMed:17109758}.


uniprotID: D6RA61
geneSymbol: USP17L22
reactome: R-HSA-5689880;
name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 22 (EC 3.4.19.12)
length: 530
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
sequence:


uniprotID: A0A1B0GUS4
geneSymbol: UBE2L5
name: Ubiquitin-conjugating enzyme E2 L5 (EC 2.3.2.23) (Ubiquitin-protein ligase L5)
length: 154
go: ENSG00000236444;
sequence:
MAASRRLMKELEEIRKCGMENFRNIQVDEANLLTWQGLIVPDNPPYNKGAFRIEINFPAEYPFKPPRITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHPLRADLAEEYSNDRKKFCKNAEEFTKKYGEKRPVD

opentargets:
ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; protein K11-linked ubiquitination [GO:0070979]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q7Z7E8
geneSymbol: UBE2Q1
reactome: R-HSA-983168;
pdb: 2QGX;
length: 422
go: ENSG00000160714;
name:
Ubiquitin-conjugating enzyme E2 Q1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme Q1) (Protein NICE-5) (Ubiquitin carrier protein Q1) (Ubiquitin-protein ligase Q1)

sequence:

opentargets:
cytosol [GO:0005829]; filopodium [GO:0030175]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; embryo implantation [GO:0007566]; fertilization [GO:0009566]; mating behavior [GO:0007617]; prolactin secretion [GO:0070459]; reproductive system development [GO:0061458]; suckling behavior [GO:0001967]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z7E8-1; Sequence=Displayed; Name=2; IsoId=Q7Z7E8-2; Sequence=VSP_017296; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7TSS2}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q7TSS2}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q7TSS2}.


uniprotID: Q9GZZ9
geneSymbol: UBA5
reactome: R-HSA-983168;
pdb: 3GUC;3H8V;5HKH;5IA8;5IAA;5L95;
length: 404
go: ENSG00000081307;
snps: rs774318611 rs532178791 rs886039761 rs886039759 rs886039762 rs114925667 rs886039760
name:
Ubiquitin-like modifier-activating enzyme 5 (Ubiquitin-activating enzyme 5) (ThiFP1) (UFM1-activating enzyme) (Ubiquitin-activating enzyme E1 domain-containing protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; UFM1 activating enzyme activity [GO:0071566]; neuromuscular process [GO:0050905]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; response to endoplasmic reticulum stress [GO:0034976]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=UBE1DC1A; IsoId=Q9GZZ9-1; Sequence=Displayed; Name=2; Synonyms=UBE1DC1B; IsoId=Q9GZZ9-2; Sequence=VSP_038528; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18442052, ECO:0000269|PubMed:26872069}. Nucleus {ECO:0000269|PubMed:18442052}. Golgi apparatus {ECO:0000269|PubMed:26872069}. Note=Localizes mainly in the cytoplasm, while it localizes to the nucleus in presence of SUMO2 (PubMed:18442052).


uniprotID: A0AVT1
geneSymbol: UBA6
reactome: R-HSA-8866652;R-HSA-983168;
length: 1052
go: ENSG00000033178;
snps: rs10010188
name:
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; FAT10 activating enzyme activity [GO:0019780]; ubiquitin activating enzyme activity [GO:0004839]; amygdala development [GO:0021764]; dendritic spine development [GO:0060996]; hippocampus development [GO:0021766]; learning [GO:0007612]; locomotory behavior [GO:0007626]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=A0AVT1-1; Sequence=Displayed; Name=2; Synonyms=nUBE1L; IsoId=A0AVT1-2; Sequence=VSP_023083; Name=3; IsoId=A0AVT1-3; Sequence=VSP_023086, VSP_023087; Name=4; IsoId=A0AVT1-4; Sequence=VSP_023084, VSP_023085; 


uniprotID: Q9BSL1
geneSymbol: UBAC1
reactome: R-HSA-983168;
pdb: 2DAI;
length: 405
go: ENSG00000130560;
snps: rs11103231
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10857748, ECO:0000269|PubMed:15531880}.
name:
Ubiquitin-associated domain-containing protein 1 (UBA domain-containing protein 1) (E3 ubiquitin-protein ligase subunit KPC2) (Glialblastoma cell differentiation-related protein 1) (Kip1 ubiquitination-promoting complex protein 2)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; protein ubiquitination [GO:0016567]


uniprotID: Q96LR5
geneSymbol: UBE2E2
reactome: R-HSA-983168;
pdb: 1Y6L;
length: 201
go: ENSG00000182247;
name:
Ubiquitin-conjugating enzyme E2 E2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E2) (UbcH8) (Ubiquitin carrier protein E2) (Ubiquitin-protein ligase E2)

sequence:

opentargets:
ATP binding [GO:0005524]; ISG15 transferase activity [GO:0042296]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; ISG15-protein conjugation [GO:0032020]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]


uniprotID: Q8NBM4
geneSymbol: UBAC2
length: 344
go: ENSG00000134882;
name:
Ubiquitin-associated domain-containing protein 2 (UBA domain-containing protein 2) (Phosphoglycerate dehydrogenase-like protein 1)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein localization to endoplasmic reticulum [GO:0070972]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8NBM4-1; Sequence=Displayed; Name=2; IsoId=Q8NBM4-2; Sequence=VSP_023911, VSP_023912; Name=3; IsoId=Q8NBM4-3; Sequence=VSP_023910; Name=4; IsoId=Q8NBM4-4; Sequence=VSP_023909; Name=5; IsoId=Q8NBM4-5; Sequence=VSP_023913, VSP_023914; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23297223}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q8IYN6
geneSymbol: UBALD2
pdb: 2DZL;
name: UBA-like domain-containing protein 2
length: 164
go: ENSG00000185262;
sequence:
MSVNMDELRHQVMINQFVLAAGCAADQAKQLLQAAHWQFETALSTFFQETNIPNSHHHHQMMCTPSNTPATPPNFPDALAMFSKLRASEGLQSSNSPMTAAACSPPANFSPFWASSPPSHQAPWIPPSSPTTFHHLHRPQPTWPPGAQQGGAQQKAMAAMDGQR


uniprotID: P60604
geneSymbol: UBE2G2
reactome: R-HSA-8866652;R-HSA-983168;
pdb: 2CYX;2KLY;2LXP;3H8K;4LAD;
length: 165
go: ENSG00000184787;
name:
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)

sequence:
MAGTALKRLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHAPGDDPMGYESSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQIVQKSLGL

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein catabolic process [GO:0044257]; cellular response to interferon-beta [GO:0035458]; negative regulation of retrograde protein transport, ER to cytosol [GO:1904153]; protein K48-linked ubiquitination [GO:0070936]; protein N-linked glycosylation via asparagine [GO:0018279]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P60604-1; Sequence=Displayed; Name=2; IsoId=P60604-2; Sequence=VSP_046260; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: O00762
geneSymbol: UBE2C
pdb: 1I7K;4YII;5A31;5KHR;5L9U;
length: 179
go: ENSG00000175063;
reactome:
R-HSA-141430;R-HSA-174048;R-HSA-174084;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-176407;R-HSA-176408;R-HSA-176409;R-HSA-176412;R-HSA-179409;R-HSA-2467813;R-HSA-2559582;R-HSA-69017;R-HSA-8866652;R-HSA-983168;

name:
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)

sequence:
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKEKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP

opentargets:
anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of exit from mitosis [GO:0031536]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O00762-1; Sequence=Displayed; Name=2; IsoId=O00762-2; Sequence=VSP_045647; Note=No experimental confirmation available.; Name=3; IsoId=O00762-3; Sequence=VSP_045648; Note=No experimental confirmation available.; Name=4; IsoId=O00762-4; Sequence=VSP_045649; Note=No experimental confirmation available.; 


uniprotID: Q969M7
geneSymbol: UBE2F
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 2EDI;3FN1;4GBA;
length: 185
go: ENSG00000184182;
name:
NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F)

sequence:
MLTLASKLKRDDGLKGSRTAATASDSTRRVSVRDKLLVKEVAELEANLPCTCKVHFPDPNKLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVDDYIKRYAR

opentargets:
cytosol [GO:0005829]; ATP binding [GO:0005524]; NEDD8 conjugating enzyme activity [GO:0061654]; NEDD8 transferase activity [GO:0019788]; post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q969M7-1; Sequence=Displayed; Name=2; IsoId=Q969M7-2; Sequence=VSP_037274; Note=No experimental confirmation available.; Name=3; IsoId=Q969M7-3; Sequence=VSP_037270; Note=No experimental confirmation available.; Name=4; IsoId=Q969M7-4; Sequence=VSP_037272, VSP_037273; Note=No experimental confirmation available.; Name=5; IsoId=Q969M7-5; Sequence=VSP_037271; Note=No experimental confirmation available.; Name=6; IsoId=Q969M7-6; Sequence=VSP_055750; Note=Gene prediction based on EST data.; Name=7; IsoId=Q969M7-7; Sequence=VSP_055749; Note=Gene prediction based on EST data.; 


uniprotID: P62256
geneSymbol: UBE2H
reactome: R-HSA-8866652;R-HSA-983168;
pdb: 2Z5D;
length: 183
go: ENSG00000186591;
name:
Ubiquitin-conjugating enzyme E2 H (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme H) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme H) (UbcH2) (Ubiquitin carrier protein H) (Ubiquitin-conjugating enzyme E2-20K) (Ubiquitin-protein ligase H)

sequence:
MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL

opentargets:
cytosol [GO:0005829]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P62256-1; Sequence=Displayed; Name=2; IsoId=P62256-2; Sequence=VSP_044580; Note=No experimental confirmation available.; 


uniprotID: Q05086
geneSymbol: UBE3A
reactome: R-HSA-983168;
pdb: 1C4Z;1D5F;1EQX;2KR1;4GIZ;4XR8;
length: 875
go: ENSG00000114062;
name:
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; brain development [GO:0007420]; positive regulation of protein ubiquitination [GO:0031398]; progesterone receptor signaling pathway [GO:0050847]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; regulation of circadian rhythm [GO:0042752]; regulation of ubiquitin-dependent protein catabolic process [GO:2000058]; response to progesterone [GO:0032570]; rhythmic process [GO:0048511]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]

snps:
rs587784511 rs587781241 rs587782907 rs587782915 rs147145506 rs587780581 rs587780582 rs587780583 rs1059383 rs587782908 rs141984760 rs587781242 rs587780584 rs587781243 rs587782916 rs587781233 rs587781244 rs587781235 rs587782918 rs587782919 rs587781236 rs587782920 rs587781237 rs587782910 rs587781239 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=II; IsoId=Q05086-1; Sequence=Displayed; Name=I; IsoId=Q05086-2; Sequence=VSP_006705; Name=III; IsoId=Q05086-3; Sequence=VSP_006706; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O08759}. Nucleus {ECO:0000250|UniProtKB:O08759}.


uniprotID: Q7Z3V4
geneSymbol: UBE3B
reactome: R-HSA-983168;
name: Ubiquitin-protein ligase E3B (EC 2.3.2.26) (HECT-type ubiquitin transferase E3B)
length: 1068
go: ENSG00000151148;
snps: rs7298565 rs398123023
sequence:

opentargets:
ubiquitin conjugating enzyme activity [GO:0061631]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=UBE3B_v1; IsoId=Q7Z3V4-1; Sequence=Displayed; Note=Major isoform.; Name=2; Synonyms=UBE3B_v2; IsoId=Q7Z3V4-2; Sequence=VSP_024087, VSP_024088; Name=3; IsoId=Q7Z3V4-3; Sequence=VSP_024085, VSP_024086; Note=No experimental confirmation available.; 


uniprotID: Q7Z6J8
geneSymbol: UBE3D
reactome: R-HSA-983168;
length: 389
go: ENSG00000118420;
snps: rs12528542 rs7739323
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
name:
E3 ubiquitin-protein ligase E3D (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase E3D) (UbcH10-binding protein with a HECT-like domain) (Ubiquitin-conjugating enzyme E2C-binding protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; ubiquitin ligase complex [GO:0000151]; cyclin binding [GO:0030332]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]


uniprotID: O95155
geneSymbol: UBE4B
pdb: 2KRE;3L1X;3L1Z;5O75;
length: 1302
go: ENSG00000130939;
snps: rs17034499
name:
Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; ubiquitin-ubiquitin ligase activity [GO:0034450]; granzyme-mediated apoptotic signaling pathway [GO:0008626]; neuron projection development [GO:0031175]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; response to UV [GO:0009411]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]; ventricular trabecula myocardium morphogenesis [GO:0003222]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O95155-1; Sequence=Displayed; Name=2; IsoId=O95155-2; Sequence=VSP_007102; Name=3; IsoId=O95155-3; Sequence=VSP_007101, VSP_007102, VSP_007103; Note=No experimental confirmation available.; Name=4; Synonyms=UFD2a-7/7a, UFD2A-III; IsoId=O95155-4; Sequence=VSP_053372; Note=Expressed exclusively in mature striated muscle cells.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17369820}. Nucleus {ECO:0000250|UniProtKB:Q9ES00}.


uniprotID: A6NDN8
name: Putative ubiquitin-like protein FUBI-like protein ENSP00000310146
length: 102
sequence:
MRGRRRAWRGAWRGGGAADLSLLCPQVAYVRARELHTLEVTGLETVAQSKAHVASLEGLIPEDKVVLLAGSPLQNEATLGQCGVEALTTLEVVGRRLGVHNV


uniprotID: Q9BZL1
geneSymbol: UBL5
pdb: 1P0R;4PYU;
name: Ubiquitin-like protein 5
sequence: MIEVVCNDRLGKKVRVKCNTDDTIGDLKKLIAAQTGTRWNKIVLKKWYTIFKDHVSLGDYEIHDGMNLELYYQ
length: 73
go: ENSG00000198258;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11161819}.
opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein tag [GO:0031386]; cellular protein modification process [GO:0006464]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein targeting to mitochondrion [GO:1903955]


uniprotID: Q92995
geneSymbol: USP13
reactome: R-HSA-5689880;R-HSA-8948751;
pdb: 2L80;2LBC;
length: 863
go: ENSG00000058056;
name:
Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; BAT3 complex binding [GO:1904288]; chaperone binding [GO:0051087]; cysteine-type endopeptidase activity [GO:0004197]; proteasome binding [GO:0070628]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-like protein ligase binding [GO:0044389]; ubiquitin-specific protease activity involved in positive regulation of ERAD pathway [GO:1904454]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; cell proliferation [GO:0008283]; maintenance of unfolded protein involved in ERAD pathway [GO:1904378]; melanocyte differentiation [GO:0030318]; positive regulation of ERAD pathway [GO:1904294]; protein deubiquitination [GO:0016579]; protein K29-linked deubiquitination [GO:0035523]; protein K6-linked deubiquitination [GO:0044313]; protein K63-linked deubiquitination [GO:0070536]; protein stabilization [GO:0050821]; regulation of autophagy [GO:0010506]; regulation of transcription, DNA-templated [GO:0006355]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92995-1; Sequence=Displayed; Name=2; IsoId=Q92995-2; Sequence=VSP_043954; Note=No experimental confirmation available.; 


uniprotID: Q14694
geneSymbol: USP10
reactome: R-HSA-5656169;R-HSA-5689880;
length: 798
go: ENSG00000103194;
snps: rs1862792 rs2326391 rs1812061
name:
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; cysteine-type endopeptidase activity [GO:0004197]; ion channel binding [GO:0044325]; p53 binding [GO:0002039]; RNA binding [GO:0003723]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; autophagy [GO:0006914]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to interleukin-1 [GO:0071347]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; protein deubiquitination [GO:0016579]; regulation of autophagy [GO:0010506]; translesion synthesis [GO:0019985]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q14694-1; Sequence=Displayed; Name=2; IsoId=Q14694-2; Sequence=VSP_038869; Name=3; IsoId=Q14694-3; Sequence=VSP_038868; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20096447}. Nucleus {ECO:0000269|PubMed:20096447, ECO:0000269|PubMed:24845384}. Early endosome {ECO:0000269|PubMed:19398555}. Note=Cytoplasmic in normal conditions (PubMed:20096447). After DNA damage, translocates to the nucleus following phosphorylation by ATM (PubMed:20096447). {ECO:0000269|PubMed:20096447}.


uniprotID: Q9UK80
geneSymbol: USP21
reactome: R-HSA-5357786;R-HSA-5357905;R-HSA-5357956;R-HSA-5689880;
pdb: 2Y5B;3I3T;3MTN;
length: 565
go: ENSG00000143258;
snps: rs34779722 rs17356051 rs1127525
name:
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; cysteine-type peptidase activity [GO:0008234]; metal ion binding [GO:0046872]; NEDD8-specific protease activity [GO:0019784]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transcription coactivator activity [GO:0003713]; histone deubiquitination [GO:0016578]; neuron projection development [GO:0031175]; positive regulation of transcription, DNA-templated [GO:0045893]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UK80-1; Sequence=Displayed; Name=2; IsoId=Q9UK80-2; Sequence=VSP_036717, VSP_036718; Note=No experimental confirmation available.; Name=3; IsoId=Q9UK80-3; Sequence=VSP_036719; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21888622}. Nucleus {ECO:0000269|PubMed:21888622}.


uniprotID: Q9Y4E8
geneSymbol: USP15
reactome: R-HSA-2173788;R-HSA-5689603;R-HSA-5689880;
pdb: 1W6V;3LMN;3PPA;3PV1;3T9L;4A3O;4A3P;5JJW;6GH9;6GHA;
length: 981
go: ENSG00000135655;
name:
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; identical protein binding [GO:0042802]; SMAD binding [GO:0046332]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transforming growth factor beta receptor binding [GO:0005160]; ubiquitin modification-dependent histone binding [GO:0061649]; BMP signaling pathway [GO:0030509]; histone H2B conserved C-terminal lysine deubiquitination [GO:0035616]; monoubiquitinated protein deubiquitination [GO:0035520]; pathway-restricted SMAD protein phosphorylation [GO:0060389]; protein deubiquitination [GO:0016579]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9Y4E8-1; Sequence=Displayed; Name=2; IsoId=Q9Y4E8-2; Sequence=VSP_005261; Name=3; IsoId=Q9Y4E8-3; Sequence=VSP_005260; Name=4; IsoId=Q9Y4E8-4; Sequence=VSP_045165, VSP_045166; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Nucleus {ECO:0000269|PubMed:21947082, ECO:0000269|PubMed:24526689}. Mitochondrion {ECO:0000269|PubMed:24852371}.


uniprotID: Q9UPT9
geneSymbol: USP22
reactome: R-HSA-3214847;R-HSA-5689880;
length: 525
go: ENSG00000124422;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5DU02}.
name:
Ubiquitin carboxyl-terminal hydrolase 22 (EC 3.4.19.12) (Deubiquitinating enzyme 22) (Ubiquitin thioesterase 22) (Ubiquitin-specific-processing protease 22)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; enzyme binding [GO:0019899]; nuclear receptor transcription coactivator activity [GO:0030374]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transcription coactivator activity [GO:0003713]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; embryo development ending in birth or egg hatching [GO:0009792]; histone deubiquitination [GO:0016578]; histone H4 acetylation [GO:0043967]; histone ubiquitination [GO:0016574]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of transcription, DNA-templated [GO:0045893]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UPT9-1; Sequence=Displayed; Name=2; IsoId=Q9UPT9-2; Sequence=VSP_036720; 


uniprotID: Q5SRN2
geneSymbol: TSBP1
name: Testis-expressed basic protein 1 (Uncharacterized protein C6orf10)
length: 563
go: ENSG00000204296;
opentargets: integral component of membrane [GO:0016021]; nucleus [GO:0005634]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

snps:
rs3129941 rs9268384 rs9268368 rs1033500 rs1265754 rs1003878 rs9405090 rs560505 rs4947338 rs34498363 rs3749966 rs7775397 rs16870005 rs7751028 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5SRN2-1; Sequence=Displayed; Name=2; IsoId=Q5SRN2-2; Sequence=VSP_014645, VSP_014646, VSP_014647; Note=No experimental confirmation available.; Name=3; IsoId=Q5SRN2-3; Sequence=VSP_014645, VSP_055702; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q92574
geneSymbol: TSC1
reactome: R-HSA-1632852;R-HSA-165181;R-HSA-380972;R-HSA-5628897;R-HSA-8854214;
pdb: 4Z6Y;5EJC;
name: Hamartin (Tuberous sclerosis 1 protein)
length: 1164
go: ENSG00000165699;
sequence:

opentargets:
cell cortex [GO:0005938]; chaperone complex [GO:0101031]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; TSC1-TSC2 complex [GO:0033596]; ATPase inhibitor activity [GO:0042030]; chaperone binding [GO:0051087]; GTPase activating protein binding [GO:0032794]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein N-terminus binding [GO:0047485]; activation of GTPase activity [GO:0090630]; adaptive immune response [GO:0002250]; adult locomotory behavior [GO:0008344]; cardiac muscle cell differentiation [GO:0055007]; cell projection organization [GO:0030030]; cell-matrix adhesion [GO:0007160]; cellular response to oxygen-glucose deprivation [GO:0090650]; cerebral cortex development [GO:0021987]; glucose import [GO:0046323]; hippocampus development [GO:0021766]; kidney development [GO:0001822]; memory T cell differentiation [GO:0043379]; myelination [GO:0042552]; negative regulation of ATPase activity [GO:0032780]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of macroautophagy [GO:0016242]; negative regulation of neuron projection development [GO:0010977]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; negative regulation of TOR signaling [GO:0032007]; negative regulation of translation [GO:0017148]; neural tube closure [GO:0001843]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macroautophagy [GO:0016239]; positive regulation of stress fiber assembly [GO:0051496]; potassium ion transport [GO:0006813]; protein heterooligomerization [GO:0051291]; protein stabilization [GO:0050821]; regulation of cell cycle [GO:0051726]; regulation of cell-matrix adhesion [GO:0001952]; regulation of neuron death [GO:1901214]; regulation of phosphoprotein phosphatase activity [GO:0043666]; regulation of protein kinase activity [GO:0045859]; regulation of stress fiber assembly [GO:0051492]; regulation of translation [GO:0006417]; response to insulin [GO:0032868]; rRNA export from nucleus [GO:0006407]; synapse organization [GO:0050808]

snps:
rs749030456 rs118203342 rs118203345 rs118203347 rs118203354 rs118203368 rs397514843 rs397514784 rs118203381 rs118203385 rs118203385 rs118203396 rs118203403 rs1060505021 rs397514834 rs118203426 rs118203436 rs118203468 rs118203468 rs1073123 rs397514808 rs397514864 rs397514840 rs77464996 rs118203518 rs118203538 rs118203543 rs118203548 rs397514880 rs118203571 rs118203576 rs75820036 rs397514800 rs397514802 rs118203639 rs118203655 rs118203657 rs118203670 rs118203692 rs397514814 rs118203699 rs118203721 rs76801599 rs397514859 rs118203742 rs118203750 rs118203753 rs397514806 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92574-1; Sequence=Displayed; Name=2; IsoId=Q92574-2; Sequence=VSP_042890; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9809973}. Membrane {ECO:0000269|PubMed:9809973}; Peripheral membrane protein {ECO:0000269|PubMed:9809973}. Note=At steady state found in association with membranes. {ECO:0000269|PubMed:9809973}.


uniprotID: P0CV99
geneSymbol: TSPY4
name: Testis-specific Y-encoded protein 4
length: 314
sequence:

opentargets:
nucleus [GO:0005634]; cell differentiation [GO:0030154]; gonadal mesoderm development [GO:0007506]; nucleosome assembly [GO:0006334]; spermatogenesis [GO:0007283]


uniprotID: A1L157
geneSymbol: TSPAN11
name: Tetraspanin-11 (Tspan-11)
length: 253
go: ENSG00000110900;
snps: rs2075333
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; cell surface receptor signaling pathway [GO:0007166]


uniprotID: P62079
geneSymbol: TSPAN5
name: Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
length: 268
go: ENSG00000168785;
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of Notch signaling pathway [GO:0045747]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q7Z4L5
geneSymbol: TTC21B
reactome: R-HSA-5610787;R-HSA-5620924;
length: 1316
go: ENSG00000123607;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
name:
Tetratricopeptide repeat protein 21B (TPR repeat protein 21B) (Intraflagellar transport 139 homolog)

sequence:

opentargets:
ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; nuclear chromatin [GO:0000790]; forebrain dorsal/ventral pattern formation [GO:0021798]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; protein localization to cilium [GO:0061512]; regulation of smoothened signaling pathway [GO:0008589]; regulation of transcription by RNA polymerase II [GO:0006357]; smoothened signaling pathway [GO:0007224]; ventricular system development [GO:0021591]

snps:
rs371571631 rs1432273 rs140511594 rs80026831 rs149925563 rs74447004 rs377061787 rs7592429 rs112868646 rs779121249 rs185089786 rs199873923 rs533077805 rs16851307 rs2163649 rs146320075 rs139441507 rs77106136 rs200291881 rs759317777 rs539769126 rs387907060 rs766811699 rs7595010 rs746700857 rs76726265 rs137926033 rs751382210 rs151227843 rs146496725 rs777427926 rs761842893 rs757541819 rs1482808126 rs1040877016 rs376308209 rs189519760 rs139537546 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z4L5-1; Sequence=Displayed; Name=2; IsoId=Q7Z4L5-2; Sequence=VSP_026306, VSP_026307; Note=No experimental confirmation available.; 


uniprotID: Q9UJK0
geneSymbol: TSR3
reactome: R-HSA-6790901;
name: Ribosome biogenesis protein TSR3 homolog
length: 312
go: ENSG00000007520;
sequence:

opentargets:
cytosol [GO:0005829]; transferase activity [GO:0016740]; maturation of SSU-rRNA [GO:0030490]; rRNA modification [GO:0000154]


uniprotID: P49746
geneSymbol: THBS3
reactome: R-HSA-186797;
name: Thrombospondin-3
length: 956
go: ENSG00000169231;
snps: rs35154152
sequence:

opentargets:
extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; heparin binding [GO:0008201]; bone trabecula formation [GO:0060346]; cell-matrix adhesion [GO:0007160]; growth plate cartilage development [GO:0003417]; ossification involved in bone maturation [GO:0043931]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P49746-1; Sequence=Displayed; Name=2; IsoId=P49746-2; Sequence=VSP_045328; 


uniprotID: P30536
geneSymbol: TSPO
reactome: R-HSA-196108;
length: 169
go: ENSG00000100300;
drug: DB01178;DB01068;DB00628;DB00829;DB00402;DB01544;DB01587;DB00186;DB00231;DB00897;DB00962;DB01198;
snps: rs6971 rs6972 rs9333342
name:
Translocator protein (Mitochondrial benzodiazepine receptor) (PKBS) (Peripheral-type benzodiazepine receptor) (PBR)

sequence:
MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAMGYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAAATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; mitochondrial outer membrane [GO:0005741]; androgen binding [GO:0005497]; benzodiazepine receptor activity [GO:0008503]; cholesterol binding [GO:0015485]; cholesterol transporter activity [GO:0017127]; ion channel binding [GO:0044325]; adrenal gland development [GO:0030325]; aging [GO:0007568]; anion transport [GO:0006820]; apoptotic process [GO:0006915]; behavioral response to pain [GO:0048266]; C21-steroid hormone biosynthetic process [GO:0006700]; cell proliferation [GO:0008283]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; contact inhibition [GO:0060242]; glial cell migration [GO:0008347]; heme biosynthetic process [GO:0006783]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of autophagy of mitochondrion [GO:1903147]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of necrotic cell death [GO:0010940]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein targeting to mitochondrion [GO:0006626]; regulation of cholesterol transport [GO:0032374]; regulation of steroid biosynthetic process [GO:0050810]; response to manganese ion [GO:0010042]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; steroid metabolic process [GO:0008202]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P30536-1; Sequence=Displayed; Name=2; Synonyms=PBR-S; IsoId=B1AH88-1; Sequence=External; Note=No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.; 

location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:1847678}; Multi-pass membrane protein {ECO:0000269|PubMed:1847678}.


uniprotID: Q6P3X3
geneSymbol: TTC27
name: Tetratricopeptide repeat protein 27 (TPR repeat protein 27)
length: 843
go: ENSG00000018699;
snps: rs2273660 rs34188947 rs2273664 rs17012268
sequence:


uniprotID: Q9NRJ4
geneSymbol: TULP4
reactome: R-HSA-8951664;
name: Tubby-related protein 4 (Tubby superfamily protein) (Tubby-like protein 4)
length: 1543
go: ENSG00000130338;
snps: rs705956 rs35262826 rs12206717 rs34622886 rs34559793 rs3749852
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; phosphatidylinositol binding [GO:0035091]; post-translational protein modification [GO:0043687]; protein localization to cilium [GO:0061512]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NRJ4-1; Sequence=Displayed; Name=2; IsoId=Q9NRJ4-2; Sequence=VSP_006676, VSP_006677; 


uniprotID: Q6EMB2
geneSymbol: TTLL5
reactome: R-HSA-8955332;
length: 1281
go: ENSG00000119685;
snps: rs2303345 rs17856074 rs199882533 rs11848004 rs10130991 rs11844617 rs1133834
name:
Tubulin polyglutamylase TTLL5 (EC 6.-.-.-) (SRC1 and TIF2-associated modulatory protein) (Tubulin--tyrosine ligase-like protein 5)

sequence:

opentargets:
centrosome [GO:0005813]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; tubulin-glutamic acid ligase activity [GO:0070740]; protein polyglutamylation [GO:0018095]; retina development in camera-type eye [GO:0060041]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6EMB2-1; Sequence=Displayed; Name=2; IsoId=Q6EMB2-2; Sequence=VSP_037453, VSP_037456, VSP_037457; Name=3; IsoId=Q6EMB2-3; Sequence=VSP_037454, VSP_037455; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:24791901}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8CHB8}. Nucleus {ECO:0000269|PubMed:17116691}. Cytoplasm {ECO:0000269|PubMed:17116691}. Note=Localized to the base of the connecting cilium between the basal body and the adjacent daughter centriole of the cilium. In osteosarcoma cells, found in both cytoplasm and nucleus in the absence of steroid but located exclusively in the nucleus in the presence of steroid. {ECO:0000250|UniProtKB:Q8CHB8, ECO:0000269|PubMed:24791901}.


uniprotID: Q6ZT98
geneSymbol: TTLL7
reactome: R-HSA-8955332;
pdb: 4YLR;4YLS;
length: 887
go: ENSG00000137941;
name:
Tubulin polyglutamylase TTLL7 (EC 6.-.-.-) (Testis development protein NYD-SP30) (Tubulin--tyrosine ligase-like protein 7)

sequence:

opentargets:
cilium [GO:0005929]; cytosol [GO:0005829]; dendrite [GO:0030425]; microtubule [GO:0005874]; perikaryon [GO:0043204]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; tubulin-glutamic acid ligase activity [GO:0070740]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]; protein polyglutamylation [GO:0018095]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZT98-1; Sequence=Displayed; Name=2; IsoId=Q6ZT98-2; Sequence=VSP_015199, VSP_015200; Name=3; IsoId=Q6ZT98-3; Sequence=VSP_015201, VSP_015202; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:A4Q9F0}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A4Q9F0}. Cell projection, dendrite {ECO:0000250|UniProtKB:A4Q9F0}. Perikaryon {ECO:0000250|UniProtKB:A4Q9F0}. Note=In cells with primary cilia, found in both cilia and basal bodies. In neuronal cells, found in dendrites and perikaryon. {ECO:0000250|UniProtKB:A4Q9F0}.


uniprotID: A6PVC2
geneSymbol: TTLL8
reactome: R-HSA-8955332;
name: Protein monoglycylase TTLL8 (EC 6.3.2.-) (Tubulin--tyrosine ligase-like protein 8)
length: 850
snps: rs59727397 rs17013076 rs9628315
sequence:

opentargets:
axoneme [GO:0005930]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; ATP binding [GO:0005524]; protein-glycine ligase activity [GO:0070735]; protein-glycine ligase activity, initiating [GO:0070736]; protein polyglycylation [GO:0018094]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6PVC2-1; Sequence=Displayed; Name=2; IsoId=A6PVC2-2; Sequence=VSP_054007, VSP_054008, VSP_054009; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.


uniprotID: Q3SXZ7
geneSymbol: TTLL9
reactome: R-HSA-8955332;
name: Probable tubulin polyglutamylase TTLL9 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 9)
length: 439
go: ENSG00000131044;
snps: rs17093689
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; microtubule [GO:0005874]; ATP binding [GO:0005524]; ligase activity [GO:0016874]; cellular protein modification process [GO:0006464]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q3SXZ7-1; Sequence=Displayed; Name=2; IsoId=Q3SXZ7-2; Sequence=VSP_035765, VSP_035767, VSP_035769; Note=No experimental confirmation available.; Name=3; IsoId=Q3SXZ7-3; Sequence=VSP_035765, VSP_035766, VSP_035767, VSP_035768; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.


uniprotID: Q8NG68
geneSymbol: TTL
reactome: R-HSA-8955332;
name: Tubulin--tyrosine ligase (TTL) (EC 6.3.2.25)
length: 377
go: ENSG00000114999;
sequence:

opentargets:
cell [GO:0005623]; ATP binding [GO:0005524]; tubulin-tyrosine ligase activity [GO:0004835]; C-terminal protein-tyrosinylation [GO:0018166]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of mitotic cell cycle [GO:0045931]; regulation of axon extension [GO:0030516]; regulation of metaphase plate congression [GO:0090235]


uniprotID: A0A0B4J249
geneSymbol: TRAV5
name: T cell receptor alpha variable 5
length: 113
go: ENSG00000211779;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKTFAGFSFLFLWLQLDCMSRGEDVEQSLFLSVREGDSSVINCTYTDSSSTYLYWYKQEPGAGLQLLTYIFSNMDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAES


uniprotID: A0A075B6U4
geneSymbol: TRAV7
name: T cell receptor alpha variable 7
length: 112
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MEKMRRPVLIIFCLCLGWANGENQVEHSPHFLGPQQGDVASMSCTYSVSRFNNLQWYRQNTGMGPKHLLSMYSAGYEKQKGRLNATLLKNGSSLYITAVQPEDSATYFCAVD


uniprotID: A0A0A6YYK1
geneSymbol: TRAV8-1
name: T cell receptor alpha variable 8-1
length: 113
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLLLIPVLGMIFALRDARAQSVSQHNHHVILSEAASLELGCNYSYGGTVNLFWYVQYPGQHLQLLLKYFSGDPLVKGIKGFEAEFIKSKFSFNLRKPSVQWSDTAEYFCAVN


uniprotID: A0A0B4J237
geneSymbol: TRAV8-2
name: T cell receptor alpha variable 8-2
length: 113
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLLLVPVLEVIFTLGGTRAQSVTQLDSHVSVSEGTPVLLRCNYSSSYSPSLFWYVQHPNKGLQLLLKYTSAATLVKGINGFEAEFKKSETSFHLTKPSAHMSDAAEYFCVVS


uniprotID: P01737
geneSymbol: TRAV8-4
reactome: R-HSA-198933;R-HSA-202424;R-HSA-202427;R-HSA-202430;R-HSA-202433;R-HSA-389948;
name: T cell receptor alpha variable 8-4 (T cell receptor alpha chain V region PY14)
length: 113
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLLLVPVLEVIFTLGGTRAQSVTQLGSHVSVSEGALVLLRCNYSSSVPPYLFWYVQYPNQGLQLLLKYTSAATLVKGINGFEAEFKKSETSFHLTKPSAHMSDAAEYFCAVS

opentargets:
plasma membrane [GO:0005886]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]


uniprotID: A0A5A6
geneSymbol: TRBV11-3
name: T cell receptor beta variable 11-3
length: 115
go: ENSG00000276597;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLLCWVAFCLLVEELIEAGVVQSPRYKIIEKKQPVAFWCNPISGHNTLYWYLQNLGQGPELLIRYENEEAVDDSQLPKDRFSAERLKGVDSTLKIQPAELGDSAVYLCASSL


uniprotID: Q9NYZ1
geneSymbol: TVP23B
name: Golgi apparatus membrane protein TVP23 homolog B
length: 205
go: ENSG00000171928;
snps: rs61075345
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of Golgi membrane [GO:0030173]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]


uniprotID: A0A0B4J2E0
geneSymbol: TRBV12-4
pdb: 5C07;5C08;5C09;5C0A;5C0B;5C0C;5HYJ;
name: T cell receptor beta variable 12-4
length: 115
go: ENSG00000276953;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGSWTLCCVSLCILVAKHTDAGVIQSPRHEVTEMGQEVTLRCKPISGHDYLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSEPRDSAVYFCASSL


uniprotID: A0A075B6N4
geneSymbol: TRBV25-1
name: T cell receptor beta variable 25-1
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MTIRLLCYVGFYFLGAGLMEADIYQTPRYLVIGTGKKITLECSQTMGHDKMYWYQQDPGMELHLIHYSYGVNSTEKGDLSSESTVSRIRTEHFPLTLESARPSHTSQYLCASSE


uniprotID: A0A0B4J240
geneSymbol: TRAV10
name: T cell receptor alpha variable 10
length: 114
go: ENSG00000211784;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKKHLTTFLVILWLYFYRGNGKNQVEQSPQSLIILEGKNCTLQCNYTVSPFSNLRWYKQDTGRGPVSLTIMTFSENTKSNGRYTATLDADTKQSSLHITASQLSDSASYICVVS


uniprotID: A0A0B4J248
geneSymbol: TRAV1-1
name: T cell receptor alpha variable 1-1
length: 108
go: ENSG00000255569;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MWGAFLLYVSMKMGGTAGQSLEQPSEVTAVEGAIVQINCTYQTSGFYGLSWYQQHDGGAPTFLSYNALDGLEETGRFSSFLSRSDSYGYLLLQELQMKDSASYFCAVR


uniprotID: A0A0A6YYD4
geneSymbol: TRBV13
name: T cell receptor beta variable 13
length: 124
go: ENSG00000276405;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLSPDLPDSAWNTRLLCRVMLCLLGAGSVAAGVIQSPRHLIKEKRETATLKCYPIPRHDTVYWYQQGPGQDPQFLISFYEKMQSDKGSIPDRFSAQQFSDYHSELNMSSLELGDSALYFCASSL


uniprotID: A0A087X0M5
geneSymbol: TRBV18
name: T cell receptor beta variable 18
length: 115
go: ENSG00000276557;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MDTRLLCCAVICLLGAGLSNAGVMQNPRHLVRRRGQEARLRCSPMKGHSHVYWYRQLPEEGLKFMVYLQKENIIDESGMPKERFSAEFPKEGPSILRIQQVVRGDSAAYFCASSP


uniprotID: A0A075B6N1
geneSymbol: TRBV19
pdb: 5HHM;5HHO;
name: T cell receptor beta variable 19
length: 114
go: ENSG00000211746;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSI


uniprotID: A0A0B4J279
geneSymbol: TRAV21
pdb: 2BNQ;2BNR;2BNU;4WW1;4WW2;5BRZ;5BS0;5EU6;
name: T cell receptor alpha variable 21
length: 112
go: ENSG00000211801;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
METLLGLLILWLQLQWVSSKQEVTQIPAALSVPEGENLVLNCSFTDSAIYNLQWFRQDPGKGLTSLLLIQSSQREQTSGRLNASLDKSSGRSTLYIAASQPGDSATYLCAVR


uniprotID: A0A087WT01
geneSymbol: TRAV27
pdb: 5HHM;5HHO;
name: T cell receptor alpha variable 27
length: 109
go: ENSG00000211809;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MVLKFSVSILWIQLAWVSTQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQTGDTGLYLCAG


uniprotID: A0A0B4J234
geneSymbol: TRAV2
name: T cell receptor alpha variable 2
length: 112
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MALQSTLGAVWLGLLLNSLWKVAESKDQVFQPSTVASSEGAVVEIFCNHSVSNAYNFFWYLHFPGCAPRLLVKGSKPSQQGRYNMTYERFSSSLLILQVREADAAVYYCAVE


uniprotID: A0A599
geneSymbol: TRBV5-6
name: T cell receptor beta variable 5-6
length: 114
go: ENSG00000211728;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGPGLLCWALLCLLGAGLVDAGVTQSPTHLIKTRGQQVTLRCSPKSGHDTVSWYQQALGQGPQFIFQYYEEEERQRGNFPDRFSGHQFPNYSSELNVNALLLGDSALYLCASSL


uniprotID: A0A5A2
geneSymbol: TRBV5-8
name: T cell receptor beta variable 5-8
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGPRLLFWALLCLLGTGPVEAGVTQSPTHLIKTRGQQATLRCSPISGHTSVYWYQQALGLGLQFLLWYDEGEERNRGNFPPRFSGRQFPNYSSELNVNALELEDSALYLCASSL


uniprotID: A0A0K0K1D8
geneSymbol: TRBV6-1
name: T cell receptor beta variable 6-1
length: 114
go: ENSG00000211706;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSIGLLCCVAFSLLWASPVNAGVTQTPKFQVLKTGQSMTLQCAQDMNHNSMYWYRQDPGMGLRLIYYSASEGTTDKGEVPNGYNVSRLNKREFSLRLESAAPSQTSVYFCASSE


uniprotID: A0A0J9YXY3
geneSymbol: TRBV6-2
name: T cell receptor beta variable 6-2
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSLGLLCCGAFSLLWAGPVNAGVTQTPKFRVLKTGQSMTLLCAQDMNHEYMYWYRQDPGMGLRLIHYSVGEGTTAKGEVPDGYNVSRLKKQNFLLGLESAAPSQTSVYFCASSY


uniprotID: A0A0B4J268
geneSymbol: TRAV4
pdb: 6AT6;6AVF;6AVG;
name: T cell receptor alpha variable 4
length: 109
go: ENSG00000211778;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MRQVARVIVFLTLSTLSLAKTTQPISMDSYEGQEVNITCSHNNIATNDYITWYQQFPSQGPRFIIQGYKTKVTNEVASLFIPADRKSSTLSLPRVSLSDTAVYYCLVGD


uniprotID: Q15672
geneSymbol: TWIST1
reactome: R-HSA-6785807;R-HSA-8878166;R-HSA-8939902;
pdb: 2MJV;
name: Twist-related protein 1 (Class A basic helix-loop-helix protein 38) (bHLHa38) (H-twist)
length: 202
go: ENSG00000122691;
snps: rs545987863 rs575299986 rs104894057 rs121909189 rs104894059 rs121909190 rs121909191
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transcription factor binding [GO:0008134]; aortic valve morphogenesis [GO:0003180]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in heart valve development [GO:2000793]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hypoxia [GO:0071456]; cranial suture morphogenesis [GO:0060363]; cytokine-mediated signaling pathway [GO:0019221]; embryonic camera-type eye formation [GO:0060900]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cushion morphogenesis [GO:0003203]; eyelid development in camera-type eye [GO:0061029]; in utero embryonic development [GO:0001701]; mitral valve morphogenesis [GO:0003183]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone acetylation [GO:0035067]; negative regulation of histone phosphorylation [GO:0033128]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of oxidative phosphorylation uncoupler activity [GO:2000276]; negative regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035359]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of tumor necrosis factor production [GO:0032720]; neural tube closure [GO:0001843]; neuron migration [GO:0001764]; odontogenesis [GO:0042476]; ossification [GO:0001503]; osteoblast differentiation [GO:0001649]; outer ear morphogenesis [GO:0042473]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell motility [GO:2000147]; positive regulation of DNA-templated transcription, initiation [GO:2000144]; positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation [GO:2000802]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of fatty acid beta-oxidation [GO:0032000]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of bone mineralization [GO:0030500]; rhythmic process [GO:0048511]; roof of mouth development [GO:0060021]


uniprotID: O95551
geneSymbol: TDP2
reactome: R-HSA-5693571;
pdb: 5INO;5J3P;5J3S;
length: 362
go: ENSG00000111802;
snps: rs35977478 rs2294689 rs17249952 rs77273535
name:
Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase)

sequence:

opentargets:
aggresome [GO:0016235]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; 5'-tyrosyl-DNA phosphodiesterase activity [GO:0070260]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; nuclease activity [GO:0004518]; single-stranded DNA binding [GO:0003697]; transcription corepressor activity [GO:0003714]; tyrosyl-RNA phosphodiesterase activity [GO:0036317]; cell surface receptor signaling pathway [GO:0007166]; double-strand break repair [GO:0006302]; neuron development [GO:0048666]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O95551-1; Sequence=Displayed; Name=2; IsoId=O95551-2; Sequence=VSP_038523; Note=No experimental confirmation available.; Name=3; IsoId=O95551-3; Sequence=VSP_038524; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Nucleus, nucleolus. Cytoplasm. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22908287}. Note=(Microbial infection) In case of infection by picornavirus, relocalizes to cytoplasmic sites distinct from those containing viral proteins associated with RNA replication or encapsidation. {ECO:0000269|PubMed:22908287}.


uniprotID: P14679
geneSymbol: TYR
reactome: R-HSA-5662702;
length: 529
go: ENSG00000077498;
drug: DB00548;DB09526;DB01055;DB00600;DB00157;
name:
Tyrosinase (EC 1.14.18.1) (LB24-AB) (Monophenol monooxygenase) (SK29-AB) (Tumor rejection antigen AB)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi-associated vesicle [GO:0005798]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; copper ion binding [GO:0005507]; monooxygenase activity [GO:0004497]; monophenol monooxygenase activity [GO:0004503]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cell proliferation [GO:0008283]; eye pigment biosynthetic process [GO:0006726]; melanin biosynthetic process [GO:0042438]; melanin biosynthetic process from tyrosine [GO:0006583]; pigmentation [GO:0043473]; response to cAMP [GO:0051591]; response to UV [GO:0009411]; response to vitamin D [GO:0033280]; thymus development [GO:0048538]; visual perception [GO:0007601]

snps:
rs61753177 rs61753178 rs61753179 rs28940878 rs755700581 rs61753180 rs61753182 rs28940879 rs61753185 rs61753184 rs544053015 rs61753188 rs28940876 rs28940877 rs137854890 rs61753252 rs61753253 rs33955261 rs11545463 rs145513733 rs61753259 rs138487695 rs779878377 rs1042602 rs750553908 rs61754362 rs28940880 rs61754363 rs63159160 rs61754365 rs63159160 rs61754367 rs774670098 rs61754369 rs61754370 rs62645902 rs104894314 rs757754120 rs200854796 rs61754375 rs61754374 rs1042608 rs61754377 rs61754378 rs61754379 rs61754380 rs372534292 rs62645906 rs62645907 rs773970123 rs62645908 rs151206295 rs61754383 rs776054795 rs61754385 rs61754387 rs61754386 rs61754388 rs61754391 rs104894315 rs121908011 rs62645914 rs752344007 rs62645916 rs1126809 rs104894316 rs62645920 rs104894313 rs61754392 rs61754393 rs758747581 rs281865325 rs281865327 rs104894317 rs104894318 rs1050708792 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P14679-1; Sequence=Displayed; Name=2; IsoId=P14679-2; Sequence=VSP_006701, VSP_006702; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000250|UniProtKB:P11344}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P11344}.


uniprotID: P17643
geneSymbol: TYRP1
reactome: R-HSA-5662702;
pdb: 5M8L;5M8M;5M8N;5M8O;5M8P;5M8Q;5M8R;5M8S;5M8T;
length: 537
go: ENSG00000107165;
snps: rs61758405 rs387907171 rs16929374 rs281865424
name:
5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA oxidase) (EC 1.14.18.-) (Catalase B) (Glycoprotein 75) (Melanoma antigen gp75) (Tyrosinase-related protein 1) (TRP) (TRP-1) (TRP1)

sequence:

opentargets:
clathrin-coated endocytic vesicle membrane [GO:0030669]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; metal ion binding [GO:0046872]; monooxygenase activity [GO:0004497]; oxidoreductase activity [GO:0016491]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; acetoacetic acid metabolic process [GO:0043438]; melanin biosynthetic process [GO:0042438]; melanin metabolic process [GO:0006582]; melanocyte differentiation [GO:0030318]; melanosome organization [GO:0032438]; positive regulation of melanin biosynthetic process [GO:0048023]

location:
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250|UniProtKB:P07147}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07147}. Melanosome {ECO:0000250|UniProtKB:P07147}. Note=Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250|UniProtKB:P07147}.


uniprotID: Q06418
geneSymbol: TYRO3
pdb: 1RHF;
length: 890
go: ENSG00000092445;
snps: rs17854578 rs12148316 rs17857363 rs1042057 rs17854579 rs17857364
location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
name:
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)

sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; integral component of plasma membrane [GO:0005887]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; phosphatidylinositol 3-kinase binding [GO:0043548]; protein heterodimerization activity [GO:0046982]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; Wnt-protein binding [GO:0017147]; apoptotic cell clearance [GO:0043277]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; forebrain cell migration [GO:0021885]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of inflammatory response [GO:0050728]; negative regulation of innate immune response [GO:0045824]; negative regulation of lymphocyte activation [GO:0051250]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of signal transduction [GO:0009968]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; neuron cellular homeostasis [GO:0070050]; neuropeptide signaling pathway [GO:0007218]; ovulation cycle [GO:0042698]; phosphatidylinositol 3-kinase signaling [GO:0014065]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; protein autophosphorylation [GO:0046777]; protein kinase B signaling [GO:0043491]; secretion by cell [GO:0032940]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; substrate adhesion-dependent cell spreading [GO:0034446]; vagina development [GO:0060068]; Wnt signaling pathway [GO:0016055]


uniprotID: Q7RTZ2
geneSymbol: USP17L1
reactome: R-HSA-5689880;
length: 530
go: ENSG00000230549;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 1 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 1) (Ubiquitin thioesterase 17-like protein 1) (Ubiquitin-specific-processing protease 17-like protein 1)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; apoptotic process [GO:0006915]; protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: C9JLJ4
geneSymbol: USP17L13
reactome: R-HSA-5689880;
name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 13 (EC 3.4.19.12)
length: 530
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
sequence:


uniprotID: D6R9N7
geneSymbol: USP17L18
reactome: R-HSA-5689880;
name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 18 (EC 3.4.19.12)
length: 530
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
sequence:


uniprotID: D6RBM5
geneSymbol: USP17L23
name: Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23
length: 183
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
sequence:
MEDDSLYLGGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMEKACLPGHKQV


uniprotID: P51668
geneSymbol: UBE2D1
pdb: 2C4P;2YHO;3OJ4;3PTF;4AP4;4QPL;5FER;5TUT;
length: 147
go: ENSG00000072401;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18845142}.
reactome:
R-HSA-1234176;R-HSA-141430;R-HSA-168927;R-HSA-174048;R-HSA-174084;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-176407;R-HSA-176408;R-HSA-176409;R-HSA-176412;R-HSA-179409;R-HSA-201451;R-HSA-202424;R-HSA-2173795;R-HSA-2467813;R-HSA-2559582;R-HSA-2871837;R-HSA-5607764;R-HSA-5689896;R-HSA-69017;R-HSA-8866652;R-HSA-8866654;R-HSA-8951664;R-HSA-9033241;R-HSA-936440;R-HSA-937041;R-HSA-983168;

name:
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)

sequence:
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; BMP signaling pathway [GO:0030509]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; protein deubiquitination [GO:0016579]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q712K3
geneSymbol: UBE2R2
reactome: R-HSA-8866652;R-HSA-983168;
length: 238
go: ENSG00000107341;
name:
Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2)

sequence:

opentargets:
cytosol [GO:0005829]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q9Y2X8
geneSymbol: UBE2D4
reactome: R-HSA-983168;
length: 147
go: ENSG00000078967;
name:
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)

sequence:
MALKRIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAREWTQKYAM

opentargets:
ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q969T4
geneSymbol: UBE2E3
reactome: R-HSA-8866652;R-HSA-983168;
length: 207
go: ENSG00000170035;
snps: rs2368192
name:
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; regulation of growth [GO:0040008]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15545318}. Cytoplasm {ECO:0000269|PubMed:15545318}. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.


uniprotID: Q5T6F2
geneSymbol: UBAP2
name: Ubiquitin-associated protein 2 (UBAP-2)
length: 1119
go: ENSG00000137073;
snps: rs1785506 rs10971809 rs307658 rs307692 rs16935295
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T6F2-1; Sequence=Displayed; Name=2; IsoId=Q5T6F2-2; Sequence=VSP_056073; Note=No experimental confirmation available.; 


uniprotID: P61081
geneSymbol: UBE2M
reactome: R-HSA-2173789;R-HSA-5607761;R-HSA-5676590;R-HSA-8951664;R-HSA-983168;
pdb: 1TT5;1Y8X;2NVU;3TDU;3TDZ;4GAO;4P5O;
length: 183
go: ENSG00000130725;
name:
NEDD8-conjugating enzyme Ubc12 (EC 2.3.2.-) (NEDD8 carrier protein) (Ubiquitin-conjugating enzyme E2 M)

sequence:
MIKLFSLKQQKKEEESAGGTKGSSKKASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLVICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETMVYHPNIDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPEDPLNKEAAEVLQNNRRLFEQNVQRSMRGGYIGSTYFERCLK

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; NEDD8 transferase activity [GO:0019788]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein modification process [GO:0006464]; positive regulation of neuron apoptotic process [GO:0043525]; post-translational protein modification [GO:0043687]; protein neddylation [GO:0045116]


uniprotID: P0CG48
geneSymbol: UBC
name: Polyubiquitin-C [Cleaved into: Ubiquitin]
length: 685
go: ENSG00000150991;
drug: DB04464;
location: SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
reactome:
R-HSA-110312;R-HSA-110314;R-HSA-110320;R-HSA-1169091;R-HSA-1169408;R-HSA-1234176;R-HSA-1236382;R-HSA-1236974;R-HSA-1253288;R-HSA-1295596;R-HSA-1358803;R-HSA-162588;R-HSA-168638;R-HSA-168927;R-HSA-168928;R-HSA-174048;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-174490;R-HSA-175474;R-HSA-179409;R-HSA-180534;R-HSA-180585;R-HSA-182971;R-HSA-187577;R-HSA-195253;R-HSA-201681;R-HSA-202424;R-HSA-205043;R-HSA-209543;R-HSA-209560;R-HSA-211733;R-HSA-2122947;R-HSA-2122948;R-HSA-2173788;R-HSA-2173791;R-HSA-2173795;R-HSA-2173796;R-HSA-2467813;R-HSA-2559580;R-HSA-2559582;R-HSA-2559585;R-HSA-2565942;R-HSA-2644606;R-HSA-2672351;R-HSA-2691232;R-HSA-2871837;R-HSA-2894862;R-HSA-2979096;R-HSA-3134975;R-HSA-3322077;R-HSA-349425;R-HSA-3769402;R-HSA-3785653;R-HSA-382556;R-HSA-400253;R-HSA-445989;R-HSA-450302;R-HSA-450321;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-4641263;R-HSA-5205685;R-HSA-532668;R-HSA-5357905;R-HSA-5357956;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5654726;R-HSA-5654727;R-HSA-5654732;R-HSA-5654733;R-HSA-5655862;R-HSA-5656121;R-HSA-5656169;R-HSA-5658442;R-HSA-5668541;R-HSA-5675221;R-HSA-5675482;R-HSA-5676590;R-HSA-5678895;R-HSA-5684264;R-HSA-5685942;R-HSA-5687128;R-HSA-5689603;R-HSA-5689877;R-HSA-5689880;R-HSA-5689896;R-HSA-5689901;R-HSA-5693565;R-HSA-5693607;R-HSA-5696394;R-HSA-5696395;R-HSA-5696397;R-HSA-5696400;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6783310;R-HSA-6804756;R-HSA-6804757;R-HSA-6804760;R-HSA-6807004;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69231;R-HSA-69481;R-HSA-69541;R-HSA-69601;R-HSA-8849469;R-HSA-8852276;R-HSA-8854050;R-HSA-8856825;R-HSA-8856828;R-HSA-8863795;R-HSA-8866652;R-HSA-8866654;R-HSA-8875360;R-HSA-8876493;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948747;R-HSA-8948751;R-HSA-8951664;R-HSA-901032;R-HSA-9010553;R-HSA-9013507;R-HSA-9013973;R-HSA-9014325;R-HSA-9020702;R-HSA-9033241;R-HSA-912631;R-HSA-917729;R-HSA-917937;R-HSA-936440;R-HSA-936964;R-HSA-937039;R-HSA-937041;R-HSA-937042;R-HSA-937072;R-HSA-9604323;R-HSA-975110;R-HSA-975144;R-HSA-975163;R-HSA-977225;R-HSA-983168;

pdb:
1C3T;1CMX;1D3Z;1F9J;1FXT;1G6J;1GJZ;1NBF;1OGW;1Q5W;1S1Q;1SIF;1TBE;1UBI;1UBQ;1UD7;1XD3;1XQQ;1YX5;1YX6;1ZGU;1ZO6;2AYO;2BGF;2DEN;2FUH;2G45;2GBJ;2GBK;2GBM;2GBN;2GBR;2GMI;2HTH;2IBI;2J7Q;2JF5;2JRI;2JY6;2JZZ;2K25;2K6D;2K8B;2K8C;2KDF;2KHW;2KJH;2KLG;2KN5;2KX0;2L3Z;2LD9;2LVO;2LVP;2LVQ;2LZ6;2MBO;2MBQ;2MCN;2MI8;2MJ5;2MOR;2MRE;2MWS;2N2K;2NR2;2O6V;2OJR;2PE9;2PEA;2RR9;2RU6;2W9N;2WDT;2XEW;2Y5B;2Z59;2ZCB;2ZVN;2ZVO;3A33;3ALB;3AUL;3B08;3B0A;3BY4;3C0R;3DVG;3DVN;3EEC;3EFU;3EHV;3H7P;3H7S;3HM3;3I3T;3IFW;3IHP;3JSV;3JVZ;3JW0;3K9O;3K9P;3KVF;3KW5;3LDZ;3MHS;3MTN;3N30;3N32;3N3K;3NS8;3O65;3OFI;3OJ3;3OJ4;3ONS;3PRM;3PT2;3PTF;3Q3F;3RUL;3TMP;3U30;3UGB;3V6C;3V6E;3VFK;3VUW;3VUX;3VUY;3WXE;3WXF;3ZLZ;3ZNH;3ZNI;3ZNZ;4AP4;4AUQ;4BOS;4BOZ;4BVU;4DDG;4DDI;4DHJ;4DHZ;4FJV;4HK2;4HXD;4I6L;4I6N;4IG7;4IUM;4JQW;4K1R;4K7S;4K7U;4K7W;4KSK;4KSL;4LCD;4LDT;4MDK;4MM3;4MSM;4MSQ;4NQK;4UN2;4V3K;4V3L;4WZP;4XOK;4XOL;4ZQS;5A5B;5AF4;5AF5;5AF6;5AIT;5AIU;5B83;5C7J;5C7M;5E6J;5H07;5NL4;5NLF;5NLI;5NMC;5OE7;5OHV;5OXH;5OXI;5UDH;5WQ4;5ZQ3;5ZQ4;5ZQ5;5ZQ6;5ZQ7;6AQR;6B7M;6B7O;6EQI;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; host cell [GO:0043657]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; protease binding [GO:0002020]; protein tag [GO:0031386]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; activation of MAPK activity [GO:0000187]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular protein metabolic process [GO:0044267]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, detection of DNA damage [GO:0042769]; endosomal transport [GO:0016197]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; global genome nucleotide-excision repair [GO:0070911]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; interleukin-1-mediated signaling pathway [GO:0070498]; interstrand cross-link repair [GO:0036297]; intracellular transport of virus [GO:0075733]; JNK cascade [GO:0007254]; membrane organization [GO:0061024]; modification-dependent protein catabolic process [GO:0019941]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; protein polyubiquitination [GO:0000209]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]; regulation of mRNA stability [GO:0043488]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; stress-activated MAPK cascade [GO:0051403]; transcription-coupled nucleotide-excision repair [GO:0006283]; transforming growth factor beta receptor signaling pathway [GO:0007179]; translesion synthesis [GO:0019985]; transmembrane transport [GO:0055085]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; viral life cycle [GO:0019058]; virion assembly [GO:0019068]; Wnt signaling pathway [GO:0016055]


uniprotID: Q15386
geneSymbol: UBE3C
reactome: R-HSA-983168;
name: Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (HectH2)
length: 1083
go: ENSG00000009335;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
intracellular [GO:0005622]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q15386-1; Sequence=Displayed; Name=2; IsoId=Q15386-2; Sequence=VSP_013956, VSP_013957; Note=No experimental confirmation available.; Name=3; IsoId=Q15386-3; Sequence=VSP_013953, VSP_013954, VSP_013955; Note=No experimental confirmation available.; 


uniprotID: Q14139
geneSymbol: UBE4A
reactome: R-HSA-983168;
pdb: 1WGM;
name: Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A)
length: 1066
go: ENSG00000110344;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:E9Q735}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; ubiquitin-ubiquitin ligase activity [GO:0034450]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14139-1; Sequence=Displayed; Name=2; IsoId=Q14139-2; Sequence=VSP_013673; Note=No experimental confirmation available.; 


uniprotID: Q96I45
geneSymbol: TMEM141
pdb: 2LOR;
name: Transmembrane protein 141
length: 108
go: ENSG00000244187;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MVNLGLSRVDDAVAAKHPGLGEYAACQSHAFMKGVFTFVTGTGMAFGLQMFIQRKFPYPLQWSLLVAVVAGSVVSYGVTRVESEKCNNLWLFLETGQLPKDRSTDQRS


uniprotID: P01375
geneSymbol: TNF
length: 233
go: ENSG00000232810;
snps: rs4645843 rs1800620
reactome:
R-HSA-381340;R-HSA-5357786;R-HSA-5357905;R-HSA-5357956;R-HSA-5626978;R-HSA-5668541;R-HSA-6783783;R-HSA-6785807;R-HSA-75893;

pdb:
1A8M;1TNF;2AZ5;2E7A;2TUN;2ZJC;2ZPX;3ALQ;3IT8;3L9J;3WD5;4G3Y;4TSV;4TWT;4Y6O;5M2I;5M2J;5M2M;5MU8;5TSW;5UUI;5WUX;5YOY;

name:
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

sequence:

opentargets:
cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic cup [GO:0001891]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; transcription regulatory region DNA binding [GO:0044212]; tumor necrosis factor receptor binding [GO:0005164]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of MAPK activity [GO:0000187]; activation of MAPKKK activity [GO:0000185]; astrocyte activation [GO:0048143]; cellular response to amino acid stimulus [GO:0071230]; cellular response to nicotine [GO:0071316]; cellular response to organic cyclic compound [GO:0071407]; chronic inflammatory response to antigenic stimulus [GO:0002439]; cognition [GO:0050890]; cortical actin cytoskeleton organization [GO:0030866]; cytokine-mediated signaling pathway [GO:0019221]; death-inducing signaling complex assembly [GO:0071550]; defense response to Gram-positive bacterium [GO:0050830]; embryonic digestive tract development [GO:0048566]; endothelial cell apoptotic process [GO:0072577]; epithelial cell proliferation involved in salivary gland morphogenesis [GO:0060664]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; glucose metabolic process [GO:0006006]; humoral immune response [GO:0006959]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; JNK cascade [GO:0007254]; leukocyte tethering or rolling [GO:0050901]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; MAPK cascade [GO:0000165]; microglial cell activation [GO:0001774]; necroptotic signaling pathway [GO:0097527]; negative regulation of alkaline phosphatase activity [GO:0010693]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of branching involved in lung morphogenesis [GO:0061048]; negative regulation of cytokine secretion involved in immune response [GO:0002740]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of gene expression [GO:0010629]; negative regulation of glucose import [GO:0046325]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of lipid catabolic process [GO:0050995]; negative regulation of lipid storage [GO:0010888]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of neurogenesis [GO:0050768]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein complex disassembly [GO:0043242]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral genome replication [GO:0045071]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of blood microparticle formation [GO:2000334]; positive regulation of calcidiol 1-monooxygenase activity [GO:0060559]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cell adhesion [GO:0045785]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000343]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of chemokine production [GO:0032722]; positive regulation of chemokine secretion [GO:0090197]; positive regulation of chronic inflammatory response to antigenic stimulus [GO:0002876]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production [GO:0001819]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fever generation [GO:0031622]; positive regulation of fractalkine biosynthetic process [GO:0050754]; positive regulation of gene expression [GO:0010628]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of hair follicle development [GO:0051798]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of leukocyte adhesion to arterial endothelial cell [GO:1904999]; positive regulation of leukocyte adhesion to vascular endothelial cell [GO:1904996]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of mononuclear cell migration [GO:0071677]; positive regulation of neuroinflammatory response [GO:0150078]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of phagocytosis [GO:0050766]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of podosome assembly [GO:0071803]; positive regulation of programmed cell death [GO:0043068]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein complex disassembly [GO:0043243]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein transport [GO:0051222]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of superoxide dismutase activity [GO:1901671]; positive regulation of synaptic transmission [GO:0050806]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of translational initiation by iron [GO:0045994]; positive regulation of vascular smooth muscle cell proliferation [GO:1904707]; positive regulation of vitamin D biosynthetic process [GO:0060557]; protein import into nucleus, translocation [GO:0000060]; protein kinase B signaling [GO:0043491]; protein localization to plasma membrane [GO:0072659]; receptor biosynthetic process [GO:0032800]; regulation of branching involved in salivary gland morphogenesis [GO:0060693]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of immunoglobulin secretion [GO:0051023]; regulation of insulin secretion [GO:0050796]; regulation of microglial cell activation [GO:1903978]; regulation of synapse organization [GO:0050807]; regulation of synaptic transmission, glutamatergic [GO:0051966]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to glucocorticoid [GO:0051384]; response to salt stress [GO:0009651]; response to virus [GO:0009615]; sequestering of triglyceride [GO:0030730]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

drug:
DB05250;DB00051;DB04956;DB05879;DB01427;DB05676;DB05066;DB08904;DB00608;DB01407;DB05744;DB05869;DB05758;DB00668;DB00005;DB01296;DB06674;DB05767;DB00065;DB02325;DB05303;DB05218;DB08910;DB01411;DB00852;DB05412;DB05207;DB01041;DB05470;DB05017;

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; SUBCELLULAR LOCATION: Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form: Secreted.; SUBCELLULAR LOCATION: C-domain 1: Secreted.; SUBCELLULAR LOCATION: C-domain 2: Secreted.


uniprotID: Q9NZC2
geneSymbol: TREM2
reactome: R-HSA-198933;R-HSA-2172127;R-HSA-2424491;R-HSA-416700;
pdb: 5ELI;5UD7;5UD8;6B8O;
length: 230
go: ENSG00000095970;
snps: rs2234253 rs2234253 rs28939079 rs2234255 rs28937876 rs150277350 rs2234256 rs200820365
name:
Triggering receptor expressed on myeloid cells 2 (TREM-2) (Triggering receptor expressed on monocytes 2)

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; lipopolysaccharide binding [GO:0001530]; lipoteichoic acid binding [GO:0070891]; peptidoglycan binding [GO:0042834]; phospholipid binding [GO:0005543]; scaffold protein binding [GO:0097110]; signaling receptor activity [GO:0038023]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to peptidoglycan [GO:0071224]; dendritic cell differentiation [GO:0097028]; detection of lipopolysaccharide [GO:0032497]; detection of lipoteichoic acid [GO:0070392]; detection of peptidoglycan [GO:0032499]; humoral immune response [GO:0006959]; innate immune response [GO:0045087]; osteoclast differentiation [GO:0030316]; phagocytosis, engulfment [GO:0006911]; positive regulation of antigen processing and presentation of peptide antigen via MHC class II [GO:0002588]; positive regulation of C-C chemokine receptor CCR7 signaling pathway [GO:1903082]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of CD40 signaling pathway [GO:2000350]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to plasma membrane [GO:1903078]; regulation of immune response [GO:0050776]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NZC2-1; Sequence=Displayed; Name=2; Synonyms=TREM-2V; IsoId=Q9NZC2-2; Sequence=VSP_010792; Note=No experimental confirmation available. {ECO:0000269|PubMed:27067662}; Name=3; IsoId=Q9NZC2-3; Sequence=VSP_010793; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:27995897}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Secreted {ECO:0000305}.


uniprotID: Q9UJV3
geneSymbol: MID2
pdb: 2DJA;2DMK;
length: 735
go: ENSG00000080561;
snps: rs551253128 rs587777605 rs12849510
location: SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
name:
Probable E3 ubiquitin-protein ligase MID2 (EC 2.3.2.27) (Midin-2) (Midline defect 2) (Midline-2) (RING finger protein 60) (RING-type E3 ubiquitin transferase MID2) (Tripartite motif-containing protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphoprotein binding [GO:0051219]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein localization to microtubule [GO:0035372]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UJV3-1; Sequence=Displayed; Name=2; IsoId=Q9UJV3-2; Sequence=VSP_009009; 


uniprotID: P03986
geneSymbol: TRGC2
pdb: 1HXM;
name: T-cell receptor gamma-2 chain C region (T-cell receptor gamma chain C region PT-gamma-1/2)
length: 189
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDIIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEESLDKEHRCIVRHENNKNGIDQEIIFPPIKTDVTTVDPKDSYSKDANDVITMDPKDNWSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLGRTAFCCNGEKS

opentargets:
integral component of plasma membrane [GO:0005887]; transmembrane signaling receptor activity [GO:0004888]; immune response [GO:0006955]


uniprotID: Q14669
geneSymbol: TRIP12
reactome: R-HSA-983168;
length: 1992
go: ENSG00000153827;
snps: rs373429636
location: SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:20208519}.
name:
E3 ubiquitin-protein ligase TRIP12 (EC 2.3.2.26) (E3 ubiquitin-protein ligase for Arf) (ULF) (HECT-type E3 ubiquitin transferase TRIP12) (Thyroid receptor-interacting protein 12) (TR-interacting protein 12) (TRIP-12)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; thyroid hormone receptor binding [GO:0046966]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; negative regulation of double-strand break repair [GO:2000780]; negative regulation of histone H2A K63-linked ubiquitination [GO:1901315]; protein polyubiquitination [GO:0000209]; regulation of embryonic development [GO:0045995]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q14669-1; Sequence=Displayed; Name=2; IsoId=Q14669-2; Sequence=VSP_044328, VSP_044329; Name=3; IsoId=Q14669-3; Sequence=VSP_044326, VSP_044328; Note=No experimental confirmation available.; Name=4; IsoId=Q14669-4; Sequence=VSP_044327, VSP_044328, VSP_044329; Note=No experimental confirmation available.; 


uniprotID: Q8TE23
geneSymbol: TAS1R2
reactome: R-HSA-418594;R-HSA-420499;
name: Taste receptor type 1 member 2 (G-protein coupled receptor 71) (Sweet taste receptor T1R2)
length: 839
go: ENSG00000179002;
drug: DB00168;
snps: rs9701796 rs35874116 rs34447754 rs28374389 rs6662276 rs41273167 rs9988418
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sweet taste receptor complex [GO:1903767]; G protein-coupled receptor activity [GO:0004930]; protein heterodimerization activity [GO:0046982]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]; sensory perception of sweet taste [GO:0050916]


uniprotID: P20231
geneSymbol: TPSB2
pdb: 1A0L;1AAO;2BM2;2FPZ;2FS8;2FS9;2FWW;2FXR;2GDD;2ZA5;3V7T;
name: Tryptase beta-2 (Tryptase-2) (EC 3.4.21.59) (Tryptase II)
length: 275
go: ENSG00000172236;
drug: DB04654;DB04764;DB02018;
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]

location:
SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation.


uniprotID: Q63HK5
geneSymbol: TSHZ3
pdb: 2DMI;
name: Teashirt homolog 3 (Zinc finger protein 537)
length: 1081
go: ENSG00000121297;
snps: rs143453460 rs4805664
sequence:

opentargets:
growth cone [GO:0030426]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; long-term synaptic potentiation [GO:0060291]; multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of synaptic transmission, glutamatergic [GO:0051968]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; regulation of transcription by RNA polymerase II [GO:0006357]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:19343227}. Cell projection, growth cone {ECO:0000250}. Note=Colocalizes with APBB1 in axonal growth cone (By similarity). Colocalizes with APBB1 in the nucleus. {ECO:0000250}.


uniprotID: P01222
geneSymbol: TSHB
reactome: R-HSA-209822;R-HSA-209968;R-HSA-375281;R-HSA-418555;
length: 138
go: ENSG00000134200;
snps: rs10776792
location: SUBCELLULAR LOCATION: Secreted.
name:
Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa)

sequence:
MTALFLMSMLFGLTCGQAMSFCIPTEYTMHIERRECAYCLTINTTICAGYCMTRDINGKLFLPKYALSQDVCTYRDFIYRTVEIPGCPLHVAPYFSYPVALSCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYLVGFSV

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; anatomical structure morphogenesis [GO:0009653]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; peptide hormone processing [GO:0016486]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to vitamin A [GO:0033189]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P01222-1; Sequence=Displayed; Name=2; IsoId=P01222-2; Sequence=VSP_053387; Note=Major isoform in peripheral blood leukocytes and thyroid, may form heterodimers with isoform 1.; 


uniprotID: Q96PF2
geneSymbol: TSSK2
length: 358
go: ENSG00000206203;
snps: rs3747052 rs35532431 rs56279111 rs35048893 rs8140743 rs1052763
name:
Testis-specific serine/threonine-protein kinase 2 (TSK-2) (TSK2) (TSSK-2) (Testis-specific kinase 2) (EC 2.7.11.1) (DiGeorge syndrome protein G) (DGS-G) (Serine/threonine-protein kinase 22B)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; peptidyl-serine phosphorylation [GO:0018105]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; spermatid development [GO:0007286]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}.


uniprotID: P16473
geneSymbol: TSHR
reactome: R-HSA-375281;R-HSA-418555;
pdb: 1XUM;2XWT;3G04;
name: Thyrotropin receptor (Thyroid-stimulating hormone receptor) (TSH-R)
length: 764
go: ENSG00000165409;
drug: DB00024;
snps: rs45499704 rs61747482 rs2234919 rs121908863 rs28937584 rs1991517
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled peptide receptor activity [GO:0008528]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; thyroid-stimulating hormone receptor activity [GO:0004996]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; cellular response to glycoprotein [GO:1904588]; cellular response to thyrotropin-releasing hormone [GO:1905229]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; hormone-mediated signaling pathway [GO:0009755]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cold-induced thermogenesis [GO:0120162]; thyroid-stimulating hormone signaling pathway [GO:0038194]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=Long; IsoId=P16473-1; Sequence=Displayed; Name=Short; IsoId=P16473-2; Sequence=VSP_001981, VSP_001982; Name=3; IsoId=P16473-3; Sequence=VSP_044643, VSP_044644; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:11847099}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: P35442
geneSymbol: THBS2
reactome: R-HSA-186797;R-HSA-5083635;R-HSA-5173214;
pdb: 1YO8;2RHP;
name: Thrombospondin-2
length: 1172
go: ENSG00000186340;
snps: rs36088849 rs35404985
sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; platelet alpha granule [GO:0031091]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; cell adhesion [GO:0007155]; negative regulation of angiogenesis [GO:0016525]; positive regulation of synapse assembly [GO:0051965]


uniprotID: Q96FV3
geneSymbol: TSPAN17
length: 270
go: ENSG00000048140;
snps: rs17624798
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Tetraspanin-17 (Tspan-17) (F-box only protein 23) (Tetraspan protein SB134) (Transmembrane 4 superfamily member 17)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; ubiquitin ligase complex [GO:0000151]; enzyme binding [GO:0019899]; ubiquitin-protein transferase activity [GO:0004842]; cell surface receptor signaling pathway [GO:0007166]; establishment of protein localization to organelle [GO:0072594]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96FV3-1; Sequence=Displayed; Name=2; IsoId=Q96FV3-3; Sequence=VSP_011391; Name=3; IsoId=Q96FV3-2; Sequence=VSP_011388, VSP_011389, VSP_011390; Name=4; IsoId=Q96FV3-4; Sequence=VSP_025608; 


uniprotID: P35443
geneSymbol: THBS4
reactome: R-HSA-186797;
name: Thrombospondin-4
length: 961
go: ENSG00000113296;
snps: rs17881847 rs1866389 rs17882372 rs2229396 rs2229398
sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; sarcoplasmic reticulum [GO:0016529]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; fibronectin binding [GO:0001968]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; integrin binding [GO:0005178]; laminin-1 binding [GO:0043237]; behavioral response to pain [GO:0048266]; endothelial cell-cell adhesion [GO:0071603]; myoblast migration [GO:0051451]; negative regulation of angiogenesis [GO:0016525]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; protein homooligomerization [GO:0051260]; regulation of tissue remodeling [GO:0034103]; response to endoplasmic reticulum stress [GO:0034976]; response to unfolded protein [GO:0006986]; tissue remodeling [GO:0048771]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Z1T2}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q9Z1T2}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9Z1T2}.


uniprotID: H0UI37
geneSymbol: TSTD3
sequence: MKIEKCGWSEGLTSIKGNCHNFYTAISKDVTYKELKNLLNSKNIMLIDVREIWEILEYQKIPESINVPLDEVGEALQMNPRDFKEKYNEVKPSKSDS
length: 97
name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3 (Rhodanese domain-containing protein 3)


uniprotID: Q6IQ55
geneSymbol: TTBK2
reactome: R-HSA-5620912;
name: Tau-tubulin kinase 2 (EC 2.7.11.1)
length: 1244
go: ENSG00000128881;
sequence:

opentargets:
centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary transition zone [GO:0035869]; cytosol [GO:0005829]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinesin binding [GO:0019894]; microtubule plus-end binding [GO:0051010]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]; cerebellar granular layer development [GO:0021681]; cerebellar granule cell precursor tangential migration [GO:0021935]; cerebellum development [GO:0021549]; ciliary basal body-plasma membrane docking [GO:0097711]; cilium assembly [GO:0060271]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of microtubule binding [GO:1904527]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of protein localization to microtubule [GO:1902817]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; regulation of cell migration [GO:0030334]; smoothened signaling pathway [GO:0007224]

snps:
rs6493068 rs35328266 rs56017612 rs764753481 rs56311523 rs56039839 rs201524659 rs202004988 rs55833708 rs34348991 rs55796513 rs146279300 rs56142516 rs36104367 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6IQ55-1; Sequence=Displayed; Name=2; IsoId=Q6IQ55-2; Sequence=VSP_018272, VSP_018275; Note=No experimental confirmation available.; Name=3; IsoId=Q6IQ55-3; Sequence=VSP_018273, VSP_018274; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. {ECO:0000250}.


uniprotID: Q96N46
geneSymbol: TTC14
name: Tetratricopeptide repeat protein 14 (TPR repeat protein 14)
length: 770
go: ENSG00000163728;
opentargets: nucleic acid binding [GO:0003676]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96N46-1; Sequence=Displayed; Name=2; IsoId=Q96N46-2; Sequence=VSP_013480, VSP_013481; Note=May be due to a competing donor splice site.; Name=3; IsoId=Q96N46-3; Sequence=VSP_047107; Note=No experimental confirmation available.; 


uniprotID: P26651
geneSymbol: ZFP36
reactome: R-HSA-450513;
pdb: 4J8S;
length: 326
snps: rs17878633 rs2229272 rs17886974 rs17884899
name:
mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; 14-3-3 protein binding [GO:0071889]; AU-rich element binding [GO:0017091]; C-C chemokine binding [GO:0019957]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; heat shock protein binding [GO:0031072]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; single-stranded RNA binding [GO:0003727]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; MAPK cascade [GO:0000165]; miRNA mediated inhibition of translation [GO:0035278]; mRNA catabolic process [GO:0006402]; mRNA transport [GO:0051028]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of interleukin-2 biosynthetic process [GO:0045085]; negative regulation of polynucleotide adenylyltransferase activity [GO:1904246]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of viral transcription [GO:0032897]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [GO:0031086]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; p38MAPK cascade [GO:0038066]; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA [GO:1901835]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of intracellular mRNA localization [GO:1904582]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; regulation of keratinocyte apoptotic process [GO:1902172]; regulation of keratinocyte differentiation [GO:0045616]; regulation of keratinocyte proliferation [GO:0010837]; regulation of mRNA stability [GO:0043488]; regulation of tumor necrosis factor production [GO:0032680]; response to starvation [GO:0042594]; response to wounding [GO:0009611]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:27182009}. Cytoplasm {ECO:0000269|PubMed:10330172, ECO:0000269|PubMed:12115244, ECO:0000269|PubMed:14766228, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:20221403}. Cytoplasmic granule {ECO:0000269|PubMed:15014438}. Cytoplasm, P-body {ECO:0000269|PubMed:17369404}. Note=Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (PubMed:20221403). Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (PubMed:17369404). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity). {ECO:0000250|UniProtKB:P22893, ECO:0000269|PubMed:15014438, ECO:0000269|PubMed:17369404, ECO:0000269|PubMed:20221403}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14679154}. Cytoplasm {ECO:0000269|PubMed:14679154}. Note=(Microbial infection) Colocalizes with HTLV-1 TAX in the nucleus and the cytoplasm in a region surrounding the nucleus. {ECO:0000269|PubMed:14679154}.


uniprotID: P50607
geneSymbol: TUB
pdb: 1S31;
name: Tubby protein homolog
length: 506
go: ENSG00000166402;
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; response to hormone [GO:0009725]; retina development in camera-type eye [GO:0060041]; sensory perception of sound [GO:0007605]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Binds phospholipid and is anchored to the plasma membrane through binding phosphatidylinositol 4,5-bisphosphate. Is released upon activation of phospholipase C. Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). {ECO:0000250}.


uniprotID: Q9NNX1
geneSymbol: TUFT1
name: Tuftelin
length: 390
go: ENSG00000143367;
snps: rs3828054 rs16833395
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; intracellular [GO:0005622]; structural constituent of tooth enamel [GO:0030345]; bone mineralization [GO:0030282]; intracellular signal transduction [GO:0035556]; odontogenesis [GO:0042476]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NNX1-1; Sequence=Displayed; Name=2; IsoId=Q9NNX1-2; Sequence=VSP_006685; Name=3; IsoId=Q9NNX1-3; Sequence=VSP_006686; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P27628}. Note=Secreted at a very early stage of enamel formation, concentrated at the dentin-enamel junction and tightly bound to the surface of the growing crystallites. {ECO:0000250|UniProtKB:P27628}.


uniprotID: O00295
geneSymbol: TULP2
name: Tubby-related protein 2 (Cancer/testis antigen 65) (CT65) (Tubby-like protein 2)
length: 520
go: ENSG00000104804;
snps: rs7260579 rs34378208 rs2270945 rs8112811
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; phosphatidylinositol binding [GO:0035091]; protein-containing complex binding [GO:0044877]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.


uniprotID: O75386
geneSymbol: TULP3
reactome: R-HSA-5610787;
name: Tubby-related protein 3 (Tubby-like protein 3)
length: 442
go: ENSG00000078246;
sequence:

opentargets:
9+0 non-motile cilium [GO:0097731]; axoneme [GO:0005930]; ciliary base [GO:0097546]; cilium [GO:0005929]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; intraciliary transport particle A binding [GO:0120160]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein-containing complex binding [GO:0044877]; anterior/posterior pattern specification [GO:0009952]; bone development [GO:0060348]; brain development [GO:0007420]; bronchus morphogenesis [GO:0060434]; central nervous system neuron differentiation [GO:0021953]; embryonic camera-type eye development [GO:0031076]; embryonic digit morphogenesis [GO:0042733]; embryonic neurocranium morphogenesis [GO:0048702]; G protein-coupled receptor signaling pathway [GO:0007186]; ganglion development [GO:0061548]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:1901621]; negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning [GO:0021914]; neural tube closure [GO:0001843]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of transcription, DNA-templated [GO:0006355]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O75386-1; Sequence=Displayed; Name=2; IsoId=O75386-2; Sequence=VSP_054752; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=3; IsoId=O75386-3; Sequence=VSP_055761, VSP_055762, VSP_055763; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding protein G(q) subunit alpha. {ECO:0000250}.


uniprotID: Q5BVD1
geneSymbol: TTMP
name: TPA-induced transmembrane protein
length: 217
go: ENSG00000114529;
opentargets: endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]
snps: rs16859172 rs16859190 rs340167
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5BVD1-1; Sequence=Displayed; Name=2; IsoId=Q5BVD1-2; Sequence=VSP_036120; Note=No experimental confirmation available.; Name=3; IsoId=Q5BVD1-3; Sequence=VSP_036121; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.


uniprotID: A0A0B4J1U6
geneSymbol: TRBV9
name: T cell receptor beta variable 9
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGFRLLCCVAFCLLGAGPVDSGVTQTPKHLITATGQRVTLRCSPRSGDLSVYWYQQSLDQGLQFLIHYYNGEERAKGNILERFSAQQFPDLHSELNLSSLELGDSALYFCASSV


uniprotID: A0A0A6YYJ7
geneSymbol: TRAV8-3
name: T cell receptor alpha variable 8-3
length: 113
go: ENSG00000211787;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLELIPLLGIHFVLRTARAQSVTQPDIHITVSEGASLELRCNYSYGATPYLFWYVQSPGQGLQLLLKYFSGDTLVQGIKGFEAEFKRSQSSFNLRKPSVHWSDAAEYFCAVG


uniprotID: A6NH52
geneSymbol: TVP23A
name: Golgi apparatus membrane protein TVP23 homolog A
length: 213
go: ENSG00000166676;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of Golgi membrane [GO:0030173]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NH52-1; Sequence=Displayed; Name=2; IsoId=A6NH52-2; Sequence=VSP_054190; Note=No experimental confirmation available.; 


uniprotID: A0A075B6T8
geneSymbol: TRAV9-1
name: T cell receptor alpha variable 9-1
length: 112
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MNSSPGPAIALFLMFGGINGDSVVQTEGQVLPSEGDSLIVNCSYETTQYPSLFWYVQYPGEGPQLHLKAMKANDKGRNKGFEAMYRKETTSFHLEKDSVQESDSAVYFCALS


uniprotID: A0A0B4J245
geneSymbol: TRAV12-1
name: T cell receptor alpha variable 12-1
length: 112
go: ENSG00000211785;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MISLRVLLVILWLQLSWVWSQRKEVEQDPGPFNVPEGATVAFNCTYSNSASQSFFWYRQDCRKEPKLLMSVYSSGNEDGRFTAQLNRASQYISLLIRDSKLSDSATYLCVVN


uniprotID: Q96ET8
geneSymbol: TVP23C
name: Golgi apparatus membrane protein TVP23 homolog C
length: 276
go: ENSG00000175106;ENSG00000259024;
snps: rs17850828 rs12150518
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of Golgi membrane [GO:0030173]; protein secretion [GO:0009306]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96ET8-1; Sequence=Displayed; Name=2; IsoId=Q96ET8-2; Sequence=VSP_017019, VSP_017020; Note=No experimental confirmation available.; Name=3; IsoId=Q96ET8-3; Sequence=VSP_040556, VSP_040557; 


uniprotID: A0A075B6N3
geneSymbol: TRBV24-1
name: T cell receptor beta variable 24-1
length: 115
go: ENSG00000211750;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MASLLFFCGAFYLLGTGSMDADVTQTPRNRITKTGKRIMLECSQTKGHDRMYWYRQDPGLGLQLIYYSFDVKDINKGEISDGYSVSRQAQAKFSLSLESAIPNQTALYFCATSDL


uniprotID: A0JD32
geneSymbol: TRAV38-2DV8
name: T cell receptor alpha variable 38-2/delta variable 8
length: 116
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MACPGFLWALVISTCLEFSMAQTVTQSQPEMSVQEAETVTLSCTYDTSESDYYLFWYKQPPSRQMILVIRQEAYKQQNATENRFSVNFQKAAKSFSLKISDSQLGDAAMYFCAYRS


uniprotID: A0A0B4J265
geneSymbol: TRAV26-2
name: T cell receptor alpha variable 26-2
length: 109
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKLVTSITVLLSLGIMGDAKTTQPNSMESNEEEPVHLPCNHSTISGTDYIHWYRQLPSQGPEYVIHGLTSNVNNRMASLAIAEDRKSSTLILHRATLRDAAVYYCILRD


uniprotID: A0A5B0
geneSymbol: TRBV14
name: T cell receptor beta variable 14
length: 115
go: ENSG00000275743;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MVSRLLSLVSLCLLGAKHIEAGVTQFPSHSVIEKGQTVTLRCDPISGHDNLYWYRRVMGKEIKFLLHFVKESKQDESGMPNNRFLAERTGGTYSTLKVQPAELEDSGVYFCASSQ


uniprotID: A0A0B4J274
geneSymbol: TRAV20
pdb: 5KS9;5KSA;5KSB;
name: T cell receptor alpha variable 20
length: 112
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MEKMLECAFIVLWLQLGWLSGEDQVTQSPEALRLQEGESSSLNCSYTVSGLRGLFWYRQDPGKGPEFLFTLYSAGEEKEKERLKATLTKKESFLHITAPKPEDSATYLCAVQ


uniprotID: A0A0K0K1B3
geneSymbol: TRBV30
name: T cell receptor beta variable 30
length: 111
go: ENSG00000237254;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLCSLLALLLGTFFGVRSQTIHQWPATLVQPVGSPLSLECTVEGTSNPNLYWYRQAAGRGLQLLFYSVGIGQISSEVPQNLSASRPQDRQFILSSKKLLLSDSGFYLCAWS


uniprotID: A0A0B4J272
geneSymbol: TRAV24
pdb: 6CPH;6CQL;6CQN;6CQQ;6CQR;
name: T cell receptor alpha variable 24
length: 114
go: ENSG00000211805;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MEKNPLAAPLLILWFHLDCVSSILNVEQSPQSLHVQEGDSTNFTCSFPSSNFYALHWYRWETAKSPEALFVMTLNGDEKKKGRISATLNTKEGYSYLYIKGSQPEDSATYLCAF


uniprotID: P04437
geneSymbol: TRAV29DV5
reactome: R-HSA-198933;R-HSA-202424;R-HSA-202427;R-HSA-202430;R-HSA-202433;R-HSA-389948;
pdb: 1BD2;
name: T cell receptor alpha variable 29/delta variable 5
length: 119
go: ENSG00000211810;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MAMLLGASVLILWLQPDWVNSQQKNDDQQVKQNSPSLSVQEGRISILNCDYTNSMFDYFLWYKKYPAEGPTFLISISSIKDKNEDGRFTVFLNKSAKHLSLHIVPSQPGDSAVYFCAAS

opentargets:
plasma membrane [GO:0005886]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; adaptive immune response [GO:0002250]; immune response [GO:0006955]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]


uniprotID: A0A087WSZ9
geneSymbol: TRAV30
name: T cell receptor alpha variable 30
length: 112
go: ENSG00000259092;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
METLLKVLSGTLLWQLTWVRSQQPVQSPQAVILREGEDAVINCSSSKALYSVHWYRQKHGEAPVFLMILLKGGEQKGHDKISASFNEKKQQSSLYLTASQLSYSGTYFCGTE


uniprotID: P0DPF4
geneSymbol: TRAV35
name: T cell receptor alpha variable 35
length: 110
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLEHLLIILWMQLTWVSGQQLNQSPQSMFIQEGEDVSMNCTSSSIFNTWLWYKQEPGEGPVLLIALYKAGELTSNGRLTAQFGITRKDSFLNISASIPSDVGIYFCAGQ


uniprotID: Q6IBS0
geneSymbol: TWF2
pdb: 2VAC;2W0I;
length: 349
go: ENSG00000247596;
snps: rs35114109 rs35711542 rs867679383
name:
Twinfilin-2 (A6-related protein) (hA6RP) (Protein tyrosine kinase 9-like) (Twinfilin-1-like protein)

sequence:

opentargets:
actin filament [GO:0005884]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; myofibril [GO:0030016]; perinuclear region of cytoplasm [GO:0048471]; stereocilium [GO:0032420]; actin filament binding [GO:0051015]; actin monomer binding [GO:0003785]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein kinase C binding [GO:0005080]; RNA binding [GO:0003723]; actin filament depolymerization [GO:0030042]; barbed-end actin filament capping [GO:0051016]; cell projection organization [GO:0030030]; cellular response to growth factor stimulus [GO:0071363]; cellular response to retinoic acid [GO:0071300]; negative regulation of actin filament polymerization [GO:0030837]; positive regulation of axon extension [GO:0045773]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of lamellipodium assembly [GO:0010591]; regulation of microvillus length [GO:0032532]; sequestering of actin monomers [GO:0042989]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10406962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000250}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization.


uniprotID: A0A0A6YYG2
geneSymbol: TRBV6-6
name: T cell receptor beta variable 6-6
length: 114
go: ENSG00000211724;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSISLLCCAAFPLLWAGPVNAGVTQTPKFRILKIGQSMTLQCAQDMNHNYMYWYRQDPGMGLKLIYYSVGAGITDKGEVPNGYNVSRSTTEDFPLRLELAAPSQTSVYFCASSY


uniprotID: A0A0K0K1E9
geneSymbol: TRBV7-7
name: T cell receptor beta variable 7-7
length: 115
go: ENSG00000253291;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTSLLCWVVLGFLGTDHTGAGVSQSPRYKVTKRGQDVTLRCDPISSHATLYWYQQALGQGPEFLTYFNYEAQPDKSGLPSDRFSAERPEGSISTLTIQRTEQRDSAMYRCASSL


uniprotID: A0A0J9YY54
geneSymbol: TEX13D
name: Testis-expressed protein 13D
length: 714
opentargets: metal ion binding [GO:0046872]
sequence:


uniprotID: Q8WVJ9
geneSymbol: TWIST2
reactome: R-HSA-8878166;
length: 160
go: ENSG00000233608;
snps: rs796065048 rs796065049 rs796065049
name:
Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)

sequence:
MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAFSVWRMEGAWSMSASH

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell migration [GO:0030335]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11062344}. Cytoplasm {ECO:0000269|PubMed:11062344}. Note=Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.


uniprotID: P40222
geneSymbol: TXLNA
reactome: R-HSA-449836;
name: Alpha-taxilin
length: 546
go: ENSG00000084652;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; cytokine activity [GO:0005125]; high molecular weight B cell growth factor receptor binding [GO:0030372]; syntaxin binding [GO:0019905]; B cell activation [GO:0042113]; cell proliferation [GO:0008283]; cytokine-mediated signaling pathway [GO:0019221]; exocytosis [GO:0006887]


uniprotID: Q9NX01
geneSymbol: TXNL4B
pdb: 1XBS;3GIX;4IN0;
name: Thioredoxin-like protein 4B (Dim1-like protein)
length: 149
go: ENSG00000140830;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15161931}.
sequence:
MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYLVDVDQTAVYTQYFDISYIPSTVFFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; cell cycle [GO:0007049]; mRNA splicing, via spliceosome [GO:0000398]


uniprotID: Q86VQ3
geneSymbol: TXNDC2
name: Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1)
length: 553
go: ENSG00000168454;
snps: rs11662946 rs2240909 rs11081510 rs2240906 rs17732496 rs17805544
sequence:

opentargets:
cytoplasm [GO:0005737]; protein disulfide oxidoreductase activity [GO:0015035]; thioredoxin-disulfide reductase activity [GO:0004791]; cell differentiation [GO:0030154]; cell redox homeostasis [GO:0045454]; glycerol ether metabolic process [GO:0006662]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86VQ3-1; Sequence=Displayed; Name=2; IsoId=Q86VQ3-2; Sequence=VSP_014328; Name=3; IsoId=Q86VQ3-3; Sequence=VSP_053684; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11399755}. Note=In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.


uniprotID: Q9BZA5
geneSymbol: TXLNGY
name: Putative gamma-taxilin 2 (Gamma-taxilin 2 pseudogene) (Taxilin gamma pseudogene, Y-linked)
length: 131
opentargets: syntaxin binding [GO:0019905]
sequence:
MEEAGLCGLREKADMLCNSESHDILQHQDSNCSATSNKHLLEDEEGRDFITKNRSWVSPVHCTQESRRELPEQEVAPPSGQQALQCNRNKEKVLGKEVLLLMQALNTLSTPEEKLAALCKKYADLGNSPLL


uniprotID: Q9H3M7
geneSymbol: TXNIP
reactome: R-HSA-844456;
pdb: 4GEI;4GEJ;4GFX;4LL1;4LL4;4ROF;4ROJ;5CQ2;5DF6;5DWS;5DZD;
name: Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
length: 391
go: ENSG00000265972;
snps: rs6674773
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial intermembrane space [GO:0005758]; nucleus [GO:0005634]; enzyme inhibitor activity [GO:0004857]; ubiquitin protein ligase binding [GO:0031625]; cell cycle [GO:0007049]; cellular response to tumor cell [GO:0071228]; keratinocyte differentiation [GO:0030216]; negative regulation of cell division [GO:0051782]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of apoptotic process [GO:0043065]; protein import into nucleus [GO:0006606]; regulation of cell proliferation [GO:0042127]; response to calcium ion [GO:0051592]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to hydrogen peroxide [GO:0042542]; response to mechanical stimulus [GO:0009612]; response to progesterone [GO:0032570]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H3M7-1; Sequence=Displayed; Name=2; IsoId=Q9H3M7-2; Sequence=VSP_054401; Note=No experimental confirmation available.; 


uniprotID: O43396
geneSymbol: TXNL1
pdb: 1GH2;1WWY;
name: Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)
length: 289
go: ENSG00000091164;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; disulfide oxidoreductase activity [GO:0015036]; cell redox homeostasis [GO:0045454]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19349277}. Nucleus {ECO:0000269|PubMed:19349277}. Note=At least 85% of the cellular TXNL1 is proteasome-associated.


uniprotID: O60830
geneSymbol: TIMM17B
reactome: R-HSA-1268020;
name: Mitochondrial import inner membrane translocase subunit Tim17-B
length: 172
go: ENSG00000126768;
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
sequence:
MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRLRGSANAVRIRAPQIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGGILLALIEGVGILLTRYTAQQFRNAPPFLEDPSQLPPKDGTPAPGYPSYQQYH

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; mitochondrial inner membrane [GO:0005743]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60830-1; Sequence=Displayed; Name=2; IsoId=O60830-2; Sequence=VSP_047215; Note=No experimental confirmation available.; 


uniprotID: Q96Q45
geneSymbol: TMEM237
length: 408
go: ENSG00000155755;
name:
Transmembrane protein 237 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein)

sequence:

opentargets:
ciliary transition zone [GO:0035869]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; cilium assembly [GO:0060271]; regulation of Wnt signaling pathway [GO:0030111]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96Q45-1; Sequence=Displayed; Name=2; IsoId=Q96Q45-2; Sequence=VSP_016628; Name=3; IsoId=Q96Q45-3; Sequence=VSP_042381; Name=4; IsoId=Q96Q45-4; Sequence=VSP_042382; Name=5; IsoId=Q96Q45-5; Sequence=VSP_042383; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:22152675}. Note=Localizes at the proximal region of primary cilia were observed, consistent with localization to the transition zone. Anchored to the transition zone by RPGRIP1L.


uniprotID: Q8N6T0
geneSymbol: TOP6BL
name: Type 2 DNA topoisomerase 6 subunit B-like (Type 2 DNA topoisomerase VI subunit B-like) (TOPOVIBL)
length: 577
go: ENSG00000173715;
sequence:

opentargets:
chromosome [GO:0005694]; meiotic DNA double-strand break formation [GO:0042138]; reciprocal meiotic recombination [GO:0007131]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=Q8N6T0-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=1; IsoId=Q8N6T0-4; Sequence=VSP_058330, VSP_058331; Note=Contains a signal peptide sequence at position 1-23. {ECO:0000255}; Name=2; IsoId=Q8N6T0-5; Sequence=VSP_058331, VSP_058332; 

location:
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:J3QMY9}. Note=Localizes to meiotic chromosomes. {ECO:0000250|UniProtKB:J3QMY9}.


uniprotID: Q9NZR1
geneSymbol: TMOD2
reactome: R-HSA-390522;
name: Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
length: 351
go: ENSG00000128872;
snps: rs34791185
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
sequence:

opentargets:
growth cone [GO:0030426]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; tropomyosin binding [GO:0005523]; learning or memory [GO:0007611]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; nervous system development [GO:0007399]; neuron-neuron synaptic transmission [GO:0007270]; pointed-end actin filament capping [GO:0051694]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NZR1-1; Sequence=Displayed; Name=2; IsoId=Q9NZR1-2; Sequence=VSP_041506; 


uniprotID: Q9Y5U5
geneSymbol: TNFRSF18
reactome: R-HSA-5669034;R-HSA-8877330;
length: 241
go: ENSG00000186891;
snps: rs11466676 rs11466687 rs11466688 rs11466693
name:
Tumor necrosis factor receptor superfamily member 18 (Activation-inducible TNFR family receptor) (Glucocorticoid-induced TNFR-related protein) (CD antigen CD357)

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; tumor necrosis factor-activated receptor activity [GO:0005031]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of regulatory T cell differentiation [GO:0045589]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y5U5-1; Sequence=Displayed; Name=2; Synonyms=GITR-D; IsoId=Q9Y5U5-2; Sequence=VSP_006508; Name=3; IsoId=Q9Y5U5-3; Sequence=VSP_041021; 


uniprotID: Q9Y2L5
geneSymbol: TRAPPC8
reactome: R-HSA-8876198;
name: Trafficking protein particle complex subunit 8 (Protein TRS85 homolog)
length: 1435
go: ENSG00000153339;
snps: rs34292533 rs6506948 rs17857486 rs754569032 rs16962530 rs2170562 rs3737374 rs36034613 rs633500
location: SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; phagophore assembly site [GO:0000407]; TRAPP complex [GO:0030008]; TRAPPIII protein complex [GO:1990072]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; autophagosome assembly [GO:0000045]; autophagy of peroxisome [GO:0030242]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; protein localization by the Cvt pathway [GO:0032258]; protein localization to phagophore assembly site [GO:0034497]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2L5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2L5-2; Sequence=VSP_014454, VSP_004000; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; 


uniprotID: Q9HC21
geneSymbol: SLC25A19
reactome: R-HSA-196819;
length: 320
go: ENSG00000125454;
snps: rs387906944 rs119473030
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
name:
Mitochondrial thiamine pyrophosphate carrier (Mitochondrial uncoupling protein 1) (Solute carrier family 25 member 19)

sequence:

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]; deoxynucleotide transmembrane transporter activity [GO:0030233]; thiamine pyrophosphate transmembrane transporter activity [GO:0090422]; thiamine transmembrane transporter activity [GO:0015234]; deoxynucleotide transport [GO:0030302]; thiamine pyrophosphate transmembrane transport [GO:0030974]; thiamine-containing compound metabolic process [GO:0042723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HC21-1; Sequence=Displayed; Name=2; IsoId=Q9HC21-2; Sequence=VSP_053908; 


