# annotation

uniprotID: Q99884
geneSymbol: SLC6A7
reactome: R-HSA-442660;R-HSA-71288;
name: Sodium-dependent proline transporter (Solute carrier family 6 member 7)
length: 636
go: ENSG00000011083;
drug: DB00172;
snps: rs1468564
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; L-proline transmembrane transporter activity [GO:0015193]; neurotransmitter:sodium symporter activity [GO:0005328]; proline:sodium symporter activity [GO:0005298]; proline transport [GO:0015824]


uniprotID: Q9HA92
geneSymbol: RSAD1
length: 442
go: ENSG00000136444;
snps: rs2290862 rs2290861 rs9891176
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
name:
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (EC 1.3.99.-) (Oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1)

sequence:

opentargets:
mitochondrion [GO:0005739]; 4 iron, 4 sulfur cluster binding [GO:0051539]; coproporphyrinogen oxidase activity [GO:0004109]; metal ion binding [GO:0046872]; porphyrin-containing compound biosynthetic process [GO:0006779]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HA92-1; Sequence=Displayed; Name=2; IsoId=Q9HA92-2; Sequence=VSP_056130, VSP_056131, VSP_056132; Note=No experimental confirmation available.; 


uniprotID: Q92737
geneSymbol: RASL10A
name: Ras-like protein family member 10A (Ras-like protein RRP22) (Ras-related protein on chromosome 22)
length: 203
go: ENSG00000100276;
sequence:

opentargets:
nucleolus [GO:0005730]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92737-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q92737-2; Sequence=VSP_013372; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus, nucleolus {ECO:0000269|PubMed:15833841}. Note=May cycle in and out of the nucleolus in a GTP-dependent manner.


uniprotID: Q92681
geneSymbol: RSC1A1
reactome: R-HSA-549127;R-HSA-8981373;
name: Regulatory solute carrier protein family 1 member 1 (Transporter regulator RS1) (hRS1)
length: 617
go: ENSG00000215695;
snps: rs3766163 rs34091519 rs3738648
sequence:

opentargets:
cell junction [GO:0030054]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel inhibitor activity [GO:0019871]; negative regulation of exocytosis [GO:0045920]; negative regulation of glucose transmembrane transport [GO:0010829]; negative regulation of transport [GO:0051051]; regulation of transcription, DNA-templated [GO:0006355]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16788147}. Nucleus {ECO:0000269|PubMed:16788147}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16788147}. Note=Localizes at the inner side of the plasma membrane.


uniprotID: A6NIM6
geneSymbol: SLC15A5
name: Solute carrier family 15 member 5
length: 579
go: ENSG00000188991;
snps: rs1799516 rs1527014 rs1671511 rs3946358
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; oligopeptide transmembrane transporter activity [GO:0035673]; peptide transmembrane transporter activity [GO:1904680]; peptide:proton symporter activity [GO:0015333]; protein transport [GO:0015031]


uniprotID: Q13183
geneSymbol: SLC13A2
reactome: R-HSA-433137;
length: 592
go: ENSG00000007216;
drug: DB00139;
snps: rs45443898 rs16964363 rs11568461 rs11568441 rs45546232 rs11568476 rs11567842
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Solute carrier family 13 member 2 (Na(+)/dicarboxylate cotransporter 1) (NaDC-1) (Renal sodium/dicarboxylate cotransporter)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; low-affinity sodium:dicarboxylate symporter activity [GO:0015361]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13183-1; Sequence=Displayed; Name=2; IsoId=Q13183-2; Sequence=VSP_046426, VSP_046427; Note=No experimental confirmation available.; Name=3; IsoId=Q13183-3; Sequence=VSP_046427; Note=No experimental confirmation available.; 


uniprotID: Q6NT16
geneSymbol: SLC18B1
name: MFS-type transporter SLC18B1 (Solute carrier family 18 member B1)
length: 456
go: ENSG00000146409;
opentargets: integral component of membrane [GO:0016021]; transmembrane transport [GO:0055085]
snps: rs59989552 rs41286192 rs6926101
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9H228
geneSymbol: S1PR5
reactome: R-HSA-418594;R-HSA-419408;
length: 398
go: ENSG00000180739;
drug: DB08868;
snps: rs35483143
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Sphingosine 1-phosphate receptor 5 (S1P receptor 5) (S1P5) (Endothelial differentiation G-protein-coupled receptor 8) (Sphingosine 1-phosphate receptor Edg-8) (S1P receptor Edg-8)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; sphingosine-1-phosphate receptor activity [GO:0038036]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of neuron differentiation [GO:0045664]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H228-1; Sequence=Displayed; Name=2; IsoId=Q9H228-2; Sequence=VSP_013369, VSP_013370; 


uniprotID: O75751
geneSymbol: SLC22A3
reactome: R-HSA-2161517;R-HSA-549127;
length: 556
go: ENSG00000146477;
snps: rs8187715 rs8187717
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; dopamine:sodium symporter activity [GO:0005330]; organic cation transmembrane transporter activity [GO:0015101]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; toxin transmembrane transporter activity [GO:0019534]; drug transmembrane transport [GO:0006855]; histamine uptake [GO:0051615]; organic cation transport [GO:0015695]; quaternary ammonium group transport [GO:0015697]; regulation of appetite [GO:0032098]

drug:
DB00718;DB08838;DB00182;DB00122;DB00501;DB00575;DB01394;DB01151;DB00988;DB00783;DB00536;DB05381;DB00458;DB00762;DB00709;DB01042;DB00331;DB01577;DB00184;DB00368;DB00526;DB00925;DB00457;DB01035;DB00396;DB00624;DB08837;DB08841;DB00541;


uniprotID: P41440
geneSymbol: SLC19A1
reactome: R-HSA-196757;
length: 591
go: ENSG00000173638;
drug: DB00563;DB06813;
snps: rs1051266 rs35786590
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Folate transporter 1 (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (Solute carrier family 19 member 1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; folate:anion antiporter activity [GO:0008518]; folic acid binding [GO:0005542]; folic acid transmembrane transporter activity [GO:0008517]; methotrexate transmembrane transporter activity [GO:0015350]; folate import across plasma membrane [GO:1904447]; folate transmembrane transport [GO:0098838]; folic acid metabolic process [GO:0046655]; folic acid transport [GO:0015884]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P41440-1; Sequence=Displayed; Name=2; IsoId=P41440-2; Sequence=VSP_042891; Note=No experimental confirmation available.; Name=3; IsoId=P41440-3; Sequence=VSP_044497; Note=No experimental confirmation available.; 


uniprotID: O60779
geneSymbol: SLC19A2
reactome: R-HSA-196819;
length: 497
go: ENSG00000117479;
drug: DB00152;
snps: rs761957186 rs28937595
name:
Thiamine transporter 1 (ThTr-1) (ThTr1) (Solute carrier family 19 member 2) (Thiamine carrier 1) (TC1)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; folic acid transmembrane transporter activity [GO:0008517]; thiamine transmembrane transporter activity [GO:0015234]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60779-1; Sequence=Displayed; Name=2; IsoId=O60779-2; Sequence=VSP_036467; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10391222, ECO:0000305|PubMed:10542220}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9BZV2
geneSymbol: SLC19A3
reactome: R-HSA-196819;
name: Thiamine transporter 2 (ThTr-2) (ThTr2) (Solute carrier family 19 member 3)
length: 496
go: ENSG00000135917;
drug: DB00151;
snps: rs121917882 rs59736804 rs34507036 rs121917884
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; thiamine transmembrane transporter activity [GO:0015234]; thiamine transmembrane transport [GO:0071934]; thiamine transport [GO:0015888]; thiamine-containing compound metabolic process [GO:0042723]; transmembrane transport [GO:0055085]


uniprotID: Q8WUG5
geneSymbol: SLC22A17
reactome: R-HSA-917937;
length: 538
go: ENSG00000092096;
name:
Solute carrier family 22 member 17 (24p3 receptor) (24p3R) (Brain-type organic cation transporter) (Lipocalin-2 receptor) (Neutrophil gelatinase-associated lipocalin receptor) (NgalR)

sequence:

opentargets:
integral component of organelle membrane [GO:0031301]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; transmembrane signaling receptor activity [GO:0004888]; transmembrane transporter activity [GO:0022857]; cellular iron ion homeostasis [GO:0006879]; ion transport [GO:0006811]; siderophore transport [GO:0015891]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=NgalR-1; IsoId=Q8WUG5-1; Sequence=Displayed; Name=2; Synonyms=NgalR-2; IsoId=Q8WUG5-2; Sequence=VSP_003774; Name=3; Synonyms=NgalR-3; IsoId=Q8WUG5-3; Sequence=VSP_039782, VSP_039783; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Vacuole membrane {ECO:0000269|PubMed:17253959}; Multi-pass membrane protein {ECO:0000269|PubMed:17253959}. Note=Upon LCN2-binding, it is internalized.


uniprotID: O15245
geneSymbol: SLC22A1
reactome: R-HSA-112311;R-HSA-181430;R-HSA-2161517;R-HSA-442660;R-HSA-549127;
name: Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1)
length: 554
go: ENSG00000175003;
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; acetylcholine transmembrane transporter activity [GO:0005277]; dopamine:sodium symporter activity [GO:0005330]; norepinephrine:sodium symporter activity [GO:0005334]; organic cation transmembrane transporter activity [GO:0015101]; protein homodimerization activity [GO:0042803]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; drug transmembrane transport [GO:0006855]; epinephrine transport [GO:0048241]; establishment or maintenance of transmembrane electrochemical gradient [GO:0010248]; organic cation transport [GO:0015695]; protein homooligomerization [GO:0051260]

drug:
DB01193;DB01614;DB03128;DB00787;DB08838;DB00915;DB00594;DB00345;DB04830;DB00520;DB01114;DB00477;DB00122;DB00501;DB00242;DB00575;DB00318;DB00987;DB04485;DB01151;DB09555;DB00917;DB01075;DB00280;DB00988;DB00668;DB00783;DB04574;DB01004;DB00406;DB00536;DB05381;DB00619;DB00458;DB00224;DB00709;DB00654;DB00331;DB00683;DB00220;DB00184;DB00368;DB00526;DB01337;DB00914;DB00925;DB01621;DB00413;DB00457;DB01032;DB01035;DB00396;DB00908;DB00468;DB00863;DB00206;DB00728;DB01232;DB03566;DB00127;DB04348;DB00624;DB08837;DB00152;DB01622;DB01623;DB01199;DB01339;DB00661;

snps:
rs34447885 rs2297373 rs12208357 rs35546288 rs55918055 rs683369 rs34104736 rs36103319 rs4646277 rs4646278 rs2282143 rs34205214 rs34130495 rs628031 rs35956182 rs34295611 rs34059508 rs35270274 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=hOCT1G/L554; IsoId=O15245-1; Sequence=Displayed; Name=2; Synonyms=hOCT1G/L506; IsoId=O15245-2; Sequence=VSP_033589, VSP_033590; Name=3; Synonyms=hOCT1G483; IsoId=O15245-3; Sequence=VSP_033588; Name=4; Synonyms=hOCT1G353; IsoId=O15245-4; Sequence=VSP_033587; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:16263091}; Multi-pass membrane protein {ECO:0000269|PubMed:16263091}.


uniprotID: A6NK97
geneSymbol: SLC22A20P
length: 555
snps: rs11605576 rs12420456 rs514076
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Solute carrier family 22 member 20 (Organic anion transporter 6) (Solute carrier family 22 member 20 pseudogene)

sequence:

opentargets:
integral component of membrane [GO:0016021]; transmembrane transporter activity [GO:0022857]; ion transport [GO:0006811]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NK97-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=A6NK97-2; Sequence=VSP_032653, VSP_032654; 


uniprotID: Q96CQ1
geneSymbol: SLC25A36
name: Solute carrier family 25 member 36
length: 311
go: ENSG00000114120;
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; pyrimidine nucleotide transmembrane transporter activity [GO:0015218]; mitochondrial genome maintenance [GO:0000002]; mitochondrion organization [GO:0007005]; pyrimidine nucleotide import into mitochondrion [GO:1990519]; pyrimidine nucleotide transport [GO:0006864]; regulation of mitochondrial membrane potential [GO:0051881]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96CQ1-1; Sequence=Displayed; Name=2; IsoId=Q96CQ1-2; Sequence=VSP_026240, VSP_026241; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q96CQ1-3; Sequence=VSP_026242; Note=No experimental confirmation available.; Name=4; IsoId=Q96CQ1-4; Sequence=VSP_035517; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:25320081}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q63ZE4
geneSymbol: SLC22A10
name: Solute carrier family 22 member 10 (Organic anion transporter 5)
length: 541
go: ENSG00000184999;
opentargets: integral component of membrane [GO:0016021]; transmembrane transporter activity [GO:0022857]
drug: DB00286;DB01032;DB00936;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q63ZE4-1; Sequence=Displayed; Name=2; IsoId=Q63ZE4-2; Sequence=VSP_056645, VSP_056646, VSP_056647; 


uniprotID: Q96DW6
geneSymbol: SLC25A38
length: 304
go: ENSG00000144659;
snps: rs34127778 rs762562272 rs121918331 rs146864395
name:
Mitochondrial glycine transporter (Mitochondrial glycine transporter GlyC) (Solute carrier family 25 member 38)

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; glycine transmembrane transporter activity [GO:0015187]; erythrocyte differentiation [GO:0030218]; glycine import into mitochondrion [GO:1904983]; heme biosynthetic process [GO:0006783]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03064}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03064}.


uniprotID: Q8IZD6
geneSymbol: SLC22A15
reactome: R-HSA-549127;
name: Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)
length: 547
go: ENSG00000163393;
snps: rs17852419
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; transmembrane transporter activity [GO:0022857]; ion transport [GO:0006811]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IZD6-1; Sequence=Displayed; Name=2; IsoId=Q8IZD6-2; Sequence=VSP_034059, VSP_034060; 


uniprotID: Q96H78
geneSymbol: SLC25A44
name: Solute carrier family 25 member 44
length: 314
go: ENSG00000160785;
snps: rs11576750
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; transmembrane transporter activity [GO:0022857]


uniprotID: Q8N413
geneSymbol: SLC25A45
name: Solute carrier family 25 member 45
length: 288
go: ENSG00000162241;
snps: rs624307 rs7108281
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; acyl carnitine transmembrane transporter activity [GO:0015227]; acyl carnitine transport [GO:0006844]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8N413-1; Sequence=Displayed; Name=2; IsoId=Q8N413-2; Sequence=VSP_026246; Note=No experimental confirmation available.; Name=3; IsoId=Q8N413-3; Sequence=VSP_026246, VSP_026248; Note=No experimental confirmation available.; Name=4; IsoId=Q8N413-4; Sequence=VSP_026247; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q8N5S1
geneSymbol: SLC25A41
name: Solute carrier family 25 member 41
length: 370
go: ENSG00000181240;
snps: rs34488963 rs11883242
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; ATP transmembrane transporter activity [GO:0005347]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:15489334}; IsoId=Q8N5S1-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:14702039}; IsoId=Q8N5S1-2; Sequence=VSP_052690, VSP_035524; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O94502}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O94502}.


uniprotID: Q6Q0C1
geneSymbol: SLC25A47
length: 308
go: ENSG00000140107;
name:
Solute carrier family 25 member 47 (Hepatocellular carcinoma down-regulated mitochondrial carrier protein)

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; acyl carnitine transmembrane transporter activity [GO:0015227]; acyl carnitine transport [GO:0006844]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6Q0C1-1; Sequence=Displayed; Name=2; IsoId=Q6Q0C1-2; Sequence=VSP_026233, VSP_026234; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15322095}; Multi-pass membrane protein {ECO:0000269|PubMed:15322095}.


uniprotID: Q8TE54
geneSymbol: SLC26A7
reactome: R-HSA-427601;
name: Anion exchange transporter (Solute carrier family 26 member 7)
length: 656
go: ENSG00000147606;
snps: rs16912250 rs34921316
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; endosome [GO:0005768]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; anion transport [GO:0006820]; bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; gastric acid secretion [GO:0001696]; ion transport [GO:0006811]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sulfate transport [GO:0008272]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:11829495}; Synonyms=1A {ECO:0000269|PubMed:11829495}, 1B {ECO:0000269|PubMed:11829495}; IsoId=Q8TE54-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:11829495, ECO:0000269|PubMed:15489334}; Synonyms=B {ECO:0000269|PubMed:15489334}; IsoId=Q8TE54-2; Sequence=VSP_052689; 

location:
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000269|PubMed:16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269|PubMed:16524946}.


uniprotID: Q8NG04
geneSymbol: SLC26A10
name: Solute carrier family 26 member 10
length: 563
go: ENSG00000135502;
snps: rs971209 rs923828 rs774895
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; regulation of membrane potential [GO:0042391]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NG04-1; Sequence=Displayed; Name=2; IsoId=Q8NG04-2; Sequence=VSP_034748, VSP_034749; Note=No experimental confirmation available.; 


uniprotID: B4DYI2
geneSymbol: SPATA31C2
name: Putative spermatogenesis-associated protein 31C2 (Protein FAM75C2)
length: 1134
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: P0C874
geneSymbol: SPATA31D3
name: Spermatogenesis-associated protein 31D3 (Protein FAM75D3)
length: 917
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q6ZUB0
geneSymbol: SPATA31D4
name: Spermatogenesis-associated protein 31D4 (Protein FAM75D4)
length: 917
go: ENSG00000189357;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q6PCB7
geneSymbol: SLC27A1
reactome: R-HSA-1989781;R-HSA-804914;
length: 646
go: ENSG00000130304;
name:
Long-chain fatty acid transport protein 1 (FATP-1) (Fatty acid transport protein 1) (EC 6.2.1.-) (Solute carrier family 27 member 1)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; protein homodimerization activity [GO:0042803]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; adiponectin-activated signaling pathway [GO:0033211]; cardiolipin biosynthetic process [GO:0032049]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; negative regulation of phospholipid biosynthetic process [GO:0071072]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; phosphatidylglycerol biosynthetic process [GO:0006655]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylserine biosynthetic process [GO:0006659]; positive regulation of heat generation [GO:0031652]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of lipid metabolic process [GO:0019216]; response to cold [GO:0009409]; response to insulin [GO:0032868]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6PCB7-1; Sequence=Displayed; Name=2; IsoId=Q6PCB7-2; Sequence=VSP_055806, VSP_055807; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Endomembrane system {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Cytoplasm {ECO:0000250|UniProtKB:Q60714}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS. Predominantly cytoplasmic in myocytes. {ECO:0000250|UniProtKB:Q60714}.


uniprotID: O14975
geneSymbol: SLC27A2
reactome: R-HSA-193368;R-HSA-193775;R-HSA-389599;R-HSA-6798695;R-HSA-9033241;
length: 620
go: ENSG00000140284;
snps: rs1648348
name:
Very long-chain acyl-CoA synthetase (VLACS) (VLCS) (EC 6.2.1.-) (Fatty acid transport protein 2) (FATP-2) (Fatty-acid-coenzyme A ligase, very long-chain 1) (Long-chain-fatty-acid--CoA ligase) (EC 6.2.1.3) (Solute carrier family 27 member 2) (THCA-CoA ligase) (Very long-chain-fatty-acid-CoA ligase)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of peroxisomal membrane [GO:0005779]; peroxisomal membrane [GO:0005778]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; ATP binding [GO:0005524]; decanoate-CoA ligase activity [GO:0102391]; enzyme binding [GO:0019899]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; phytanate-CoA ligase activity [GO:0050197]; pristanate-CoA ligase activity [GO:0070251]; signaling receptor binding [GO:0005102]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; bile acid biosynthetic process [GO:0006699]; fatty acid alpha-oxidation [GO:0001561]; fatty acid beta-oxidation [GO:0006635]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; methyl-branched fatty acid metabolic process [GO:0097089]; neutrophil degranulation [GO:0043312]; protein targeting to peroxisome [GO:0006625]; very long-chain fatty acid catabolic process [GO:0042760]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14975-1; Sequence=Displayed; Name=2; IsoId=O14975-2; Sequence=VSP_042726; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein. Note=Peripheral membrane associated with the lumenal side of peroxisomes.


uniprotID: O43511
geneSymbol: SLC26A4
reactome: R-HSA-427601;R-HSA-5619046;
name: Pendrin (Sodium-independent chloride/iodide transporter) (Solute carrier family 26 member 4)
length: 780
go: ENSG00000091137;
sequence:

opentargets:
apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; iodide transmembrane transporter activity [GO:0015111]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; inorganic anion transport [GO:0015698]; ion transport [GO:0006811]; regulation of membrane potential [GO:0042391]; regulation of pH [GO:0006885]; regulation of protein localization [GO:0032880]; sensory perception of sound [GO:0007605]; sulfate transport [GO:0008272]

snps:
rs111033423 rs1268256689 rs539699299 rs111033205 rs370588279 rs141142414 rs1442599990 rs145254330 rs984967571 rs121908365 rs111033199 rs772023020 rs760413427 rs542620119 rs111033348 rs111033303 rs80338848 rs111033256 rs1315422549 rs727505080 rs34373141 rs36039758 rs111033212 rs121908361 rs121908364 rs111033244 rs201562855 rs397516414 rs111033305 rs111033305 rs111033220 rs28939086 rs201660407 rs111033307 rs768471577 rs375576481 rs200511789 rs111033308 rs111033316 rs111033254 rs747636919 rs763006761 rs111033257 rs55638457 rs17154335 rs121908360 rs111033309 rs111033318 rs1060499808 rs35548413 rs981410021 rs121908363 rs121908362 rs994170964 rs17154353 rs111033255 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43511-1; Sequence=Displayed; Name=2; IsoId=O43511-2; Sequence=VSP_056688; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney. {ECO:0000250}.


uniprotID: Q96G79
geneSymbol: SLC35A4
name: Probable UDP-sugar transporter protein SLC35A4 (Solute carrier family 35 member A4)
length: 324
go: ENSG00000176087;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of Golgi membrane [GO:0030173]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]; sialic acid transmembrane transporter activity [GO:0015136]; carbohydrate transport [GO:0008643]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=1; IsoId=Q96G79-1; Sequence=Displayed; Name=2; Synonyms=uORF {ECO:0000303|PubMed:25621764}; IsoId=L0R6Q1-1; Sequence=External; Note=Product of the upstream open reading frame of this bicistronic gene. This may be the major product of the gene under normal conditions. {ECO:0000269|PubMed:25621764}; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q91ZR7}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: P58743
geneSymbol: SLC26A5
name: Prestin (Solute carrier family 26 member 5)
length: 744
go: ENSG00000170615;
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; lateral plasma membrane [GO:0016328]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; protein homodimerization activity [GO:0042803]; secondary active sulfate transmembrane transporter activity [GO:0008271]; spectrin binding [GO:0030507]; sulfate transmembrane transporter activity [GO:0015116]; transcription factor binding [GO:0008134]; cochlea development [GO:0090102]; fructose transmembrane transport [GO:0015755]; negative regulation of ion transmembrane transport [GO:0034766]; positive regulation of cell motility [GO:2000147]; positive regulation of cell size [GO:0045793]; protein tetramerization [GO:0051262]; regulation of cell shape [GO:0008360]; regulation of membrane potential [GO:0042391]; response to auditory stimulus [GO:0010996]; response to ischemia [GO:0002931]; response to potassium ion [GO:0035864]; response to salicylic acid [GO:0009751]; response to salt [GO:1902074]; response to thyroid hormone [GO:0097066]; sensory perception of sound [GO:0007605]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=SLC26A5a; IsoId=P58743-1; Sequence=Displayed; Name=2; Synonyms=SLC26A5b; IsoId=P58743-2; Sequence=VSP_010194, VSP_010195; Name=3; Synonyms=SLC26A5c; IsoId=P58743-3; Sequence=VSP_010192, VSP_010193; Name=4; Synonyms=SLC26A5d; IsoId=P58743-4; Sequence=VSP_010190, VSP_010191; Name=5; IsoId=P58743-5; Sequence=VSP_043153; Note=No experimental confirmation available.; Name=6; IsoId=P58743-6; Sequence=VSP_043153, VSP_047640; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Lateral wall of outer hair cells. {ECO:0000250}.


uniprotID: O00337
geneSymbol: SLC28A1
reactome: R-HSA-83936;
length: 649
go: ENSG00000156222;
drug: DB00441;DB00649;DB00495;
snps: rs2290272 rs45523532 rs8187758 rs2242047 rs2242046 rs45584739
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; nucleoside transmembrane transporter activity [GO:0005337]; nucleoside:sodium symporter activity [GO:0005415]; pyrimidine- and adenine-specific:sodium symporter activity [GO:0015389]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; nucleoside transport [GO:0015858]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00337-1; Sequence=Displayed; Name=2; IsoId=O00337-2; Sequence=VSP_037221, VSP_037222; 


uniprotID: O43868
geneSymbol: SLC28A2
reactome: R-HSA-83936;
length: 658
go: ENSG00000137860;
drug: DB01033;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Sodium/nucleoside cotransporter 2 (Concentrative nucleoside transporter 2) (CNT 2) (hCNT2) (Na(+)/nucleoside cotransporter 2) (Sodium-coupled nucleoside transporter 2) (Sodium/purine nucleoside co-transporter) (SPNT) (Solute carrier family 28 member 2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; nucleoside transmembrane transporter activity [GO:0005337]; nucleoside:sodium symporter activity [GO:0005415]; purine nucleoside transmembrane transporter activity [GO:0015211]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]

snps:
rs567096708 rs11854484 rs1060896 rs115740452 rs2271437 rs113624548 rs10519020 rs17215633 rs376327143 rs17222057 rs9635306 rs373539209 


uniprotID: Q9H1N7
geneSymbol: SLC35B3
reactome: R-HSA-174362;R-HSA-727802;
length: 401
go: ENSG00000124786;
name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (3'-phosphoadenosine 5'-phosphosulfate transporter) (PAPS transporter 2) (Solute carrier family 35 member B3)

sequence:

opentargets:
Golgi membrane [GO:0000139]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of Golgi membrane [GO:0030173]; 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H1N7-1; Sequence=Displayed; Name=2; IsoId=Q9H1N7-2; Sequence=VSP_016193, VSP_016194; Note=No experimental confirmation available.; Name=3; IsoId=Q9H1N7-3; Sequence=VSP_016195, VSP_016196; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16492677}; Multi-pass membrane protein {ECO:0000269|PubMed:16492677}.


uniprotID: Q9HAS3
geneSymbol: SLC28A3
reactome: R-HSA-83936;
name: Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3)
length: 691
go: ENSG00000197506;
drug: DB00640;DB00242;DB04485;DB01073;DB00441;DB04335;DB01033;DB00811;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; nucleoside transmembrane transporter activity [GO:0005337]; nucleoside:sodium symporter activity [GO:0005415]; purine-specific nucleoside:sodium symporter activity [GO:0015390]; pyrimidine- and adenine-specific:sodium symporter activity [GO:0015389]; nucleoside transmembrane transport [GO:1901642]; purine nucleoside transmembrane transport [GO:0015860]; pyrimidine nucleoside transport [GO:0015864]

snps:
rs11568401 rs11568403 rs45621433 rs11568411 rs10868138 rs11140503 rs11568418 rs45525131 rs140138960 rs11568388 rs11568405 rs56350726 rs11568398 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HAS3-1; Sequence=Displayed; Name=2; Synonyms=hCNT3ins; IsoId=Q9HAS3-2; Sequence=VSP_053848; Note=Exhibits a shorter half-life than isoform 1, degraded via a proteasome-dependent pathway.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.


uniprotID: Q99808
geneSymbol: SLC29A1
reactome: R-HSA-83936;
length: 456
go: ENSG00000112759;
drug: DB00987;DB00900;DB00898;DB01073;DB00544;DB00441;DB01033;DB00642;DB00811;DB00197;DB02745;DB00943;
snps: rs45573936 rs45458701 rs767108156
name:
Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; nucleoside transmembrane transporter activity [GO:0005337]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; excitatory postsynaptic potential [GO:0060079]; lactation [GO:0007595]; neurotransmitter reuptake [GO:0098810]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transport [GO:0015858]; sleep [GO:0030431]; uridine transport [GO:0015862]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99808-1; Sequence=Displayed; Name=2; IsoId=Q99808-2; Sequence=VSP_056579; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Predominantly localized in the basolateral membrane in polarized MDCK cells.


uniprotID: Q8TBE7
geneSymbol: SLC35G2
name: Solute carrier family 35 member G2 (Transmembrane protein 22)
length: 412
go: ENSG00000168917;
snps: rs1052618
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19148500}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q8N808
geneSymbol: SLC35G3
name: Solute carrier family 35 member G3 (Acyl-malonyl-condensing enzyme 1) (Transmembrane protein 21A)
length: 338
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9NTN3
geneSymbol: SLC35D1
reactome: R-HSA-173599;R-HSA-5579020;R-HSA-727802;
length: 355
go: ENSG00000116704;
snps: rs10157422
name:
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter (UDP-GlcA/UDP-GalNAc transporter) (Solute carrier family 35 member D1) (UDP-galactose transporter-related protein 7) (UGTrel7)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]; UDP-glucuronic acid transmembrane transporter activity [GO:0005461]; carbohydrate transport [GO:0008643]; chondroitin sulfate biosynthetic process [GO:0030206]; embryonic skeletal system development [GO:0048706]; UDP-glucuronate biosynthetic process [GO:0006065]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NTN3-1; Sequence=Displayed; Name=2; IsoId=Q9NTN3-2; Sequence=VSP_056860, VSP_056861; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11322953}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9BZD2
geneSymbol: SLC29A3
reactome: R-HSA-5619063;R-HSA-83936;
name: Equilibrative nucleoside transporter 3 (hENT3) (Solute carrier family 29 member 3)
length: 475
go: ENSG00000198246;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nucleoside transmembrane transporter activity [GO:0005337]

snps:
rs2277257 rs267607057 rs780668 rs143557881 rs1023257012 rs2252996 rs79737301 rs2487068 rs387907066 rs387907067 rs144517514 rs121912583 rs121912584 rs267607058 rs999940 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BZD2-1; Sequence=Displayed; Name=2; IsoId=Q9BZD2-2; Sequence=VSP_037436; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface.


uniprotID: Q5M8T2
geneSymbol: SLC35D3
name: Solute carrier family 35 member D3 (Fringe connection-like protein 1)
length: 416
go: ENSG00000182747;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; carbohydrate transport [GO:0008643]; energy homeostasis [GO:0097009]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]


uniprotID: Q96K37
geneSymbol: SLC35E1
name: Solute carrier family 35 member E1
length: 410
go: ENSG00000127526;
opentargets: Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96K37-1; Sequence=Displayed; Name=2; IsoId=Q96K37-2; Sequence=VSP_010139; Note=No experimental confirmation available.; Name=3; IsoId=Q96K37-3; Sequence=VSP_031351, VSP_010140, VSP_010141; Note=No experimental confirmation available.; 


uniprotID: Q495N2
geneSymbol: SLC36A3
length: 470
snps: rs978012 rs12520516 rs17660042 rs13155282 rs13155520
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Proton-coupled amino acid transporter 3 (Proton/amino acid transporter 3) (Solute carrier family 36 member 3) (Tramdorin-2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:proton symporter activity [GO:0005280]; glycine transmembrane transporter activity [GO:0015187]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; proton transmembrane transporter activity [GO:0015078]; amino acid transmembrane transport [GO:0003333]; glycine transport [GO:0015816]; L-alanine transport [GO:0015808]; proline transmembrane transport [GO:0035524]; proton transmembrane transport [GO:1902600]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q495N2-1; Sequence=Displayed; Name=2; IsoId=Q495N2-2; Sequence=VSP_032601, VSP_032602; Note=No experimental confirmation available.; Name=3; IsoId=Q495N2-3; Sequence=VSP_032602; 


uniprotID: Q9NVC3
geneSymbol: SLC38A7
name: Putative sodium-coupled neutral amino acid transporter 7 (Solute carrier family 38 member 7)
length: 462
go: ENSG00000103042;
snps: rs7193572 rs7191331
sequence:

opentargets:
axon [GO:0030424]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; amino acid transmembrane transporter activity [GO:0015171]; L-alanine transmembrane transporter activity [GO:0015180]; L-amino acid transmembrane transporter activity [GO:0015179]; L-asparagine transmembrane transporter activity [GO:0015182]; L-aspartate transmembrane transporter activity [GO:0015183]; L-glutamate transmembrane transporter activity [GO:0005313]; L-glutamine transmembrane transporter activity [GO:0015186]; L-histidine transmembrane transporter activity [GO:0005290]; L-leucine transmembrane transporter activity [GO:0015190]; L-methionine transmembrane transporter activity [GO:0015191]; L-serine transmembrane transporter activity [GO:0015194]; amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NVC3-1; Sequence=Displayed; Name=2; IsoId=Q9NVC3-2; Sequence=VSP_031511; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=In neurons, located in soma and axons. {ECO:0000250}.


uniprotID: Q8NBW4
geneSymbol: SLC38A9
reactome: R-HSA-1632852;R-HSA-165159;R-HSA-166208;R-HSA-380972;R-HSA-5628897;R-HSA-8943724;
length: 561
go: ENSG00000177058;
snps: rs4865615
name:
Sodium-coupled neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)

sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nucleoplasm [GO:0005654]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transmembrane transport [GO:0003333]; cell cycle arrest [GO:0007050]; cellular response to amino acid stimulus [GO:0071230]; positive regulation of TOR signaling [GO:0032008]; regulation of macroautophagy [GO:0016241]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8NBW4-1; Sequence=Displayed; Name=2; IsoId=Q8NBW4-2; Sequence=VSP_032815; Note=No experimental confirmation available.; Name=3; IsoId=Q8NBW4-3; Sequence=VSP_045111, VSP_045112; Name=4; IsoId=Q8NBW4-4; Sequence=VSP_045110; 

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25561175, ECO:0000269|PubMed:25567906}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:25561175}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q92504
geneSymbol: SLC39A7
reactome: R-HSA-442380;
length: 469
go: ENSG00000112473;
snps: rs34211188 rs35690712 rs1048778
name:
Zinc transporter SLC39A7 (Histidine-rich membrane protein Ke4) (Really interesting new gene 5 protein) (Solute carrier family 39 member 7) (Zrt-, Irt-like protein 7) (ZIP7)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; zinc ion transmembrane transport [GO:0071577]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane.


uniprotID: Q8WUX1
geneSymbol: SLC38A5
reactome: R-HSA-352230;
length: 472
go: ENSG00000017483;
snps: rs17281188
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
name:
Sodium-coupled neutral amino acid transporter 5 (Solute carrier family 38 member 5) (System N transporter 2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; glycine transmembrane transporter activity [GO:0015187]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WUX1-1; Sequence=Displayed; Name=2; IsoId=Q8WUX1-2; Sequence=VSP_029702; Note=No experimental confirmation available.; 


uniprotID: Q9NP94
geneSymbol: SLC39A2
reactome: R-HSA-442380;
length: 309
go: ENSG00000165794;
snps: rs2234633 rs2234634 rs2234636 rs6413532 rs2234637
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Zinc transporter ZIP2 (6A1) (Eti-1) (Solute carrier family 39 member 2) (Zrt- and Irt-like protein 2) (ZIP-2) (hZIP2)

sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; zinc ion transmembrane transport [GO:0071577]; zinc ion transport [GO:0006829]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NP94-1; Sequence=Displayed; Name=2; IsoId=Q9NP94-2; Sequence=VSP_046889, VSP_046890; Note=Gene prediction based on EST data.; 


uniprotID: Q9NP59
geneSymbol: SLC40A1
reactome: R-HSA-425410;R-HSA-5619049;R-HSA-5655799;R-HSA-917937;
name: Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
length: 571
go: ENSG00000138449;
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; ferrous iron transmembrane transporter activity [GO:0015093]; identical protein binding [GO:0042802]; iron channel activity [GO:0097689]; iron ion transmembrane transporter activity [GO:0005381]; peptide hormone binding [GO:0017046]; cellular iron ion homeostasis [GO:0006879]; endothelium development [GO:0003158]; ferrous iron export across plasma membrane [GO:1903988]; iron ion transmembrane transport [GO:0034755]; lymphocyte homeostasis [GO:0002260]; multicellular organismal iron ion homeostasis [GO:0060586]; negative regulation of apoptotic process [GO:0043066]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395]; spleen trabecula formation [GO:0060345]

snps:
rs1285653301 rs28939076 rs978427853 rs104893673 rs104893662 rs1434101655 rs104893663 rs1397119020 rs104893672 rs104893670 rs11568350 rs104893664 rs368420430 rs104893671 rs11568355 rs45606432 rs1060501102 rs11568346 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802}; Multi-pass membrane protein {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802}. Note=Localized to the basolateral membrane of polarized epithelial cells.


uniprotID: Q96H72
geneSymbol: SLC39A13
length: 371
go: ENSG00000165915;
snps: rs2010519 rs35978122
name:
Zinc transporter ZIP13 (LIV-1 subfamily of ZIP zinc transporter 9) (LZT-Hs9) (Solute carrier family 39 member 13) (Zrt- and Irt-like protein 13) (ZIP-13)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of Golgi membrane [GO:0030173]; integral component of membrane [GO:0016021]; perinuclear region of cytoplasm [GO:0048471]; protein homodimerization activity [GO:0042803]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; connective tissue development [GO:0061448]; response to zinc ion [GO:0010043]; zinc ion transmembrane transport [GO:0071577]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96H72-1; Sequence=Displayed; Name=2; IsoId=Q96H72-2; Sequence=VSP_029819; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21917916}; Multi-pass membrane protein {ECO:0000269|PubMed:21917916}.


uniprotID: Q96JW4
geneSymbol: SLC41A2
reactome: R-HSA-425410;
name: Solute carrier family 41 member 2
length: 573
go: ENSG00000136052;
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; divalent inorganic cation transmembrane transporter activity [GO:0072509]; magnesium ion transmembrane transporter activity [GO:0015095]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16984228}; Multi-pass membrane protein {ECO:0000269|PubMed:16984228}.


uniprotID: Q6U841
geneSymbol: SLC4A10
reactome: R-HSA-425381;
name: Sodium-driven chloride bicarbonate exchanger (Solute carrier family 4 member 10)
length: 1118
go: ENSG00000144290;
drug: DB01390;
sequence:

opentargets:
apical dendrite [GO:0097440]; basal dendrite [GO:0097441]; basolateral plasma membrane [GO:0016323]; CA3 pyramidal cell dendrite [GO:0097442]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; inorganic anion exchanger activity [GO:0005452]; sodium:bicarbonate symporter activity [GO:0008510]; bicarbonate transport [GO:0015701]; brain morphogenesis [GO:0048854]; chloride transport [GO:0006821]; locomotory exploration behavior [GO:0035641]; multicellular organism growth [GO:0035264]; post-embryonic development [GO:0009791]; proton transmembrane transport [GO:1902600]; pyramidal neuron development [GO:0021860]; regulation of intracellular pH [GO:0051453]; response to light stimulus [GO:0009416]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6U841-1; Sequence=Displayed; Name=2; IsoId=Q6U841-2; Sequence=VSP_019653; Name=3; IsoId=Q6U841-3; Sequence=VSP_044993, VSP_019653; Note=No experimental confirmation available.; Name=4; IsoId=Q6U841-4; Sequence=VSP_054471, VSP_054472; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane. {ECO:0000250}.


uniprotID: Q5BKX6
geneSymbol: SLC45A4
name: Solute carrier family 45 member 4
length: 768
go: ENSG00000022567;
snps: rs753778 rs3739238
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; sucrose:proton symporter activity [GO:0008506]; sucrose transport [GO:0015770]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5BKX6-1; Sequence=Displayed; Name=2; IsoId=Q5BKX6-2; Sequence=VSP_033540, VSP_033541; Name=3; IsoId=Q5BKX6-3; Sequence=VSP_033540, VSP_033541, VSP_033542; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q86VL8
geneSymbol: SLC47A2
reactome: R-HSA-425366;
length: 602
go: ENSG00000180638;
drug: DB00787;
snps: rs34399035
name:
Multidrug and toxin extrusion protein 2 (MATE-2) (hMATE-2) (Kidney-specific H(+)/organic cation antiporter) (Solute carrier family 47 member 2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; drug transmembrane transporter activity [GO:0015238]; drug:proton antiporter activity [GO:0015307]; drug transmembrane transport [GO:0006855]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q86VL8-1; Sequence=Displayed; Name=2; IsoId=Q86VL8-2; Sequence=VSP_029656, VSP_029658, VSP_029663, VSP_029664; Note=No experimental confirmation available.; Name=3; Synonyms=MATE2-K; IsoId=Q86VL8-3; Sequence=VSP_029658; Note=No experimental confirmation available.; Name=4; IsoId=Q86VL8-4; Sequence=VSP_029658, VSP_029662; Note=No experimental confirmation available.; Name=5; IsoId=Q86VL8-5; Sequence=VSP_029658, VSP_029660, VSP_029661; Note=No experimental confirmation available.; Name=6; Synonyms=MATE2-B; IsoId=Q86VL8-6; Sequence=VSP_029657, VSP_029659; Note=Inactive. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the brush border membranes of the proximal tubules.


uniprotID: Q8TDM5
geneSymbol: SPACA4
reactome: R-HSA-163125;
name: Sperm acrosome membrane-associated protein 4 (Sperm acrosomal membrane-associated protein 14)
length: 124
go: ENSG00000177202;
sequence:
MVLCWLLLLVMALPPGTTGVKDCVFCELTDSMQCPGTYMHCGDDEDCFTGHGVAPGTGPVINKGCLRATSCGLEEPVSYRGVTYSLTTNCCTGRLCNRAPSSQTVGATTSLALGLGMLLPPRLL

opentargets:
acrosomal vesicle [GO:0001669]; anchored component of membrane [GO:0031225]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12788941}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12788941}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12788941}. Note=Expressed in acrosomal matrix and outer and inner acrosomal membranes. {ECO:0000269|PubMed:12788941}.


uniprotID: Q96E40
geneSymbol: SPACA9
name: Sperm acrosome-associated protein 9
length: 222
go: ENSG00000165698;
snps: rs2231406
sequence:

opentargets:
acrosomal vesicle [GO:0001669]; ciliary basal body [GO:0036064]; cytoplasmic microtubule [GO:0005881]; motile cilium [GO:0031514]; nucleus [GO:0005634]; calcium-dependent protein binding [GO:0048306]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96E40-1; Sequence=Displayed; Name=2; IsoId=Q96E40-2; Sequence=VSP_014456, VSP_014457; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q7TPM5}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7TPM5}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q7TPM5}. Nucleus {ECO:0000250|UniProtKB:Q4V8P4}. Note=In caudal sperms localizes onto sperm head. Is also present on midpiece and principle piece of sperm tails. Acrosome and sperm tail localization is regulated by Y-chromosome. {ECO:0000250|UniProtKB:Q7TPM5}.


uniprotID: Q96HN2
geneSymbol: AHCYL2
reactome: R-HSA-425381;
pdb: 3GVP;
length: 611
go: ENSG00000158467;
name:
Adenosylhomocysteinase 3 (AdoHcyase 3) (EC 3.3.1.1) (IP(3)Rs binding protein released with IP(3) 2) (IRBIT2) (Long-IRBIT) (S-adenosyl-L-homocysteine hydrolase 3) (S-adenosylhomocysteine hydrolase-like protein 2)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005]; hydrolase activity [GO:0016787]; one-carbon metabolic process [GO:0006730]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96HN2-1; Sequence=Displayed; Name=2; IsoId=Q96HN2-2; Sequence=VSP_040095; Note=No experimental confirmation available.; Name=3; IsoId=Q96HN2-3; Sequence=VSP_043185, VSP_043186; Note=No experimental confirmation available.; Name=4; IsoId=Q96HN2-4; Sequence=VSP_046278, VSP_046279; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A6QLP2, ECO:0000250|UniProtKB:Q68FL4}. Microsome {ECO:0000250|UniProtKB:Q68FL4}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250|UniProtKB:Q68FL4}.


uniprotID: Q8N8I0
geneSymbol: SAMD12
name: Sterile alpha motif domain-containing protein 12 (SAM domain-containing protein 12)
length: 201
go: ENSG00000177570;
sequence:


uniprotID: Q9P1V8
geneSymbol: SAMD15
name: Sterile alpha motif domain-containing protein 15 (SAM domain-containing protein 15)
length: 674
go: ENSG00000100583;
snps: rs11844594 rs45527334 rs4903576 rs2193595
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P1V8-1; Sequence=Displayed; Name=2; IsoId=Q9P1V8-2; Sequence=VSP_023431, VSP_023432; 


uniprotID: Q8IVG5
geneSymbol: SAMD9L
name: Sterile alpha motif domain-containing protein 9-like (SAM domain-containing protein 9-like)
length: 1584
go: ENSG00000177409;
opentargets: cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosomal vesicle fusion [GO:0034058]
snps: rs10488532 rs2073793 rs878855336 rs17165111 rs878855337 rs10282508
location: SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q69Z37}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IVG5-1; Sequence=Displayed; Name=2; Synonyms=UEF3; IsoId=Q8IVG5-2; Sequence=VSP_027875; Note=No experimental confirmation available. Dubious isoform produced through aberrant splice sites.; 


uniprotID: Q6NUJ1
geneSymbol: PSAPL1
length: 521
go: ENSG00000178597;
snps: rs11548325 rs58482081 rs56737582 rs3796905 rs6850206
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Proactivator polypeptide-like 1 [Cleaved into: Saposin A-like; Saposin B-Val-like; Saposin B-like; Saposin C-like; Saposin D-like]

sequence:

opentargets:
cytosol [GO:0005829]; extracellular space [GO:0005615]; lysosome [GO:0005764]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; prostate gland growth [GO:0060736]; regulation of lipid metabolic process [GO:0019216]; sphingolipid metabolic process [GO:0006665]


uniprotID: P07602
geneSymbol: PSAP
reactome: R-HSA-114608;R-HSA-1660662;R-HSA-375276;R-HSA-418594;R-HSA-6798695;
pdb: 1M12;1N69;1SN6;2DOB;2GTG;2QYP;2R0R;2R1Q;2RB3;2Z9A;3BQP;3BQQ;4DDJ;4UEX;4V2O;
length: 524
go: ENSG00000197746;
drug: DB01966;
snps: rs121918107 rs770171865 rs121918103 rs121918104 rs121918110
name:
Prosaposin (Proactivator polypeptide) [Cleaved into: Saposin-A (Protein A); Saposin-B-Val; Saposin-B (Cerebroside sulfate activator) (CSAct) (Dispersin) (Sphingolipid activator protein 1) (SAP-1) (Sulfatide/GM1 activator); Saposin-C (A1 activator) (Co-beta-glucosidase) (Glucosylceramidase activator) (Sphingolipid activator protein 2) (SAP-2); Saposin-D (Component C) (Protein C)]

sequence:

opentargets:
azurophil granule membrane [GO:0035577]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal lumen [GO:0043202]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; beta-galactosidase activity [GO:0004565]; enzyme activator activity [GO:0008047]; G protein-coupled receptor binding [GO:0001664]; ganglioside GM1 binding [GO:1905573]; ganglioside GM2 binding [GO:1905574]; ganglioside GM3 binding [GO:1905575]; ganglioside GP1c binding [GO:1905577]; ganglioside GT1b binding [GO:1905576]; identical protein binding [GO:0042802]; lipid binding [GO:0008289]; phospholipid binding [GO:0005543]; protein homodimerization activity [GO:0042803]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to organic substance [GO:0071310]; epithelial cell differentiation involved in prostate gland development [GO:0060742]; G protein-coupled receptor signaling pathway [GO:0007186]; ganglioside GM1 transport to membrane [GO:1905572]; glycosphingolipid metabolic process [GO:0006687]; lipid transport [GO:0006869]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; neutrophil degranulation [GO:0043312]; platelet degranulation [GO:0002576]; positive regulation of MAPK cascade [GO:0043410]; prostate gland growth [GO:0060736]; regulation of autophagy [GO:0010506]; regulation of lipid metabolic process [GO:0019216]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=Sap-mu-0; IsoId=P07602-1; Sequence=Displayed; Name=Sap-mu-6; IsoId=P07602-2; Sequence=VSP_006014; Name=Sap-mu-9; IsoId=P07602-3; Sequence=VSP_006015; 

location:
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:21835174, ECO:0000269|PubMed:22431521}.; SUBCELLULAR LOCATION: Prosaposin: Secreted {ECO:0000250|UniProtKB:Q61207}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000250|UniProtKB:Q61207}.


uniprotID: Q9NR31
geneSymbol: SAR1A
pdb: 2GAO;
name: GTP-binding protein SAR1a (COPII-associated small GTPase)
length: 198
go: ENSG00000079332;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
sequence:
MSFIFEWIYNGFSSVLQFLGLYKKSGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHEQARRVWKNYLPAINGIVFLVDCADHSRLVESKVELNALMTDETISNVPILILGNKIDRTDAISEEKLREIFGLYGQTTGKGNVTLKELNARPMEVFMCSVLKRQGYGEGFRWLSQYID

opentargets:
COPII vesicle coat [GO:0030127]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; Golgi membrane [GO:0000139]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cargo loading into COPII-coated vesicle [GO:0090110]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; regulation of COPII vesicle coating [GO:0003400]; vesicle organization [GO:0016050]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NR31-1; Sequence=Displayed; Name=2; IsoId=Q9NR31-2; Sequence=VSP_056220; Note=No experimental confirmation available.; 


uniprotID: Q9BW04
geneSymbol: SARG
name: Specifically androgen-regulated gene protein
length: 601
go: ENSG00000182795;
snps: rs706846 rs35299018 rs34660159 rs12062114 rs35267170 rs2842726 rs11799966
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15525603}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9BW04-1; Sequence=Displayed; Name=2; IsoId=Q9BW04-2; Sequence=VSP_031228; 


uniprotID: Q9Y6X3
geneSymbol: MAU2
reactome: R-HSA-2470946;
name: MAU2 chromatid cohesion factor homolog (MAU-2) (Cohesin loading complex subunit SCC4 homolog)
length: 613
go: ENSG00000129933;
sequence:

opentargets:
chromatin [GO:0000785]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Scc2-Scc4 cohesin loading complex [GO:0090694]; SMC loading complex [GO:0032116]; double-stranded DNA binding [GO:0003690]; protein N-terminus binding [GO:0047485]; cell division [GO:0051301]; cohesin loading [GO:0071921]; maintenance of mitotic sister chromatid cohesion [GO:0034088]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y6X3-1; Sequence=Displayed; Name=2; IsoId=Q9Y6X3-2; Sequence=VSP_021224, VSP_021226; Name=3; IsoId=Q9Y6X3-3; Sequence=VSP_021223, VSP_021225; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:16682347, ECO:0000269|PubMed:16802858}. Nucleus {ECO:0000269|PubMed:28167679}. Chromosome {ECO:0000250|UniProtKB:Q9D2X5}. Note=Binds to chromatin from the end of mitosis until prophase.


uniprotID: Q6ZMJ2
geneSymbol: SCARA5
reactome: R-HSA-3000480;
name: Scavenger receptor class A member 5 (Scavenger receptor hlg)
length: 495
go: ENSG00000168079;
snps: rs17058374 rs17058207
sequence:

opentargets:
cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]; ferritin receptor activity [GO:0070287]; scavenger receptor activity [GO:0005044]; cellular iron ion homeostasis [GO:0006879]; cellular response to heat [GO:0034605]; endocytosis [GO:0006897]; iron ion transmembrane transport [GO:0034755]; protein homotrimerization [GO:0070207]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZMJ2-1; Sequence=Displayed; Name=2; IsoId=Q6ZMJ2-2; Sequence=VSP_023474, VSP_023475; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZMJ2-3; Sequence=VSP_023472, VSP_023474, VSP_023475; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZMJ2-4; Sequence=VSP_023473; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03070}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_03070}.


uniprotID: O95171
geneSymbol: SCEL
name: Sciellin
length: 688
go: ENSG00000136155;
snps: rs34164479 rs2274016 rs8002725
sequence:

opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; embryo development ending in birth or egg hatching [GO:0009792]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; response to mechanical stimulus [GO:0009612]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O95171-1; Sequence=Displayed; Name=2; IsoId=O95171-2; Sequence=VSP_035980; Name=3; IsoId=O95171-3; Sequence=VSP_045288, VSP_045289; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=May become cross-linked to membrane proteins by transglutaminase.


uniprotID: O15127
geneSymbol: SCAMP2
name: Secretory carrier-associated membrane protein 2 (Secretory carrier membrane protein 2)
length: 329
go: ENSG00000140497;
sequence:

opentargets:
extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; recycling endosome membrane [GO:0055038]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}. Recycling endosome membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}.


uniprotID: Q9UQR0
geneSymbol: SCML2
pdb: 1OI1;2BIV;2MEM;2VYT;4EDU;
name: Sex comb on midleg-like protein 2
length: 700
go: ENSG00000102098;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; PcG protein complex [GO:0031519]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; anatomical structure morphogenesis [GO:0009653]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UQR0-1; Sequence=Displayed; Name=2; IsoId=Q9UQR0-2; Sequence=VSP_010277; Note=No experimental confirmation available.; 


uniprotID: Q96I15
geneSymbol: SCLY
reactome: R-HSA-2408508;
pdb: 3GZC;3GZD;
name: Selenocysteine lyase (hSCL) (EC 4.4.1.16)
length: 445
go: ENSG00000132330;
drug: DB00114;
snps: rs7597367 rs3210400 rs35637307
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; selenocysteine lyase activity [GO:0009000]; transferase activity [GO:0016740]; cellular amino acid metabolic process [GO:0006520]; selenium compound metabolic process [GO:0001887]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96I15-1; Sequence=Displayed; Name=2; IsoId=Q96I15-2; Sequence=VSP_030854; 


uniprotID: Q6NUK1
geneSymbol: SLC25A24
pdb: 4N5X;4ZCU;4ZCV;
length: 477
go: ENSG00000085491;
name:
Calcium-binding mitochondrial carrier protein SCaMC-1 (Mitochondrial ATP-Mg/Pi carrier protein 1) (Mitochondrial Ca(2+)-dependent solute carrier protein 1) (Small calcium-binding mitochondrial carrier protein 1) (Solute carrier family 25 member 24)

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; ATP transmembrane transporter activity [GO:0005347]; calcium ion binding [GO:0005509]; ATP transport [GO:0015867]; cellular response to calcium ion [GO:0071277]; cellular response to oxidative stress [GO:0034599]; mitochondrial transport [GO:0006839]; regulation of cell death [GO:0010941]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NUK1-1; Sequence=Displayed; Name=2; IsoId=Q6NUK1-2; Sequence=VSP_031066; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}; Multi-pass membrane protein {ECO:0000269|PubMed:15054102, ECO:0000269|PubMed:15123600, ECO:0000269|PubMed:22015608}.


uniprotID: Q9Y5Y9
geneSymbol: SCN10A
reactome: R-HSA-445095;R-HSA-5576892;
length: 1956
go: ENSG00000185313;
name:
Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8)

sequence:

opentargets:
axon [GO:0030424]; clathrin complex [GO:0071439]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; integral component of presynaptic membrane [GO:0099056]; plasma membrane [GO:0005886]; voltage-gated sodium channel complex [GO:0001518]; ion channel binding [GO:0044325]; voltage-gated ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; AV node cell action potential [GO:0086016]; bundle of His cell action potential [GO:0086043]; membrane depolarization during action potential [GO:0086010]; neuronal action potential [GO:0019228]; odontogenesis of dentin-containing tooth [GO:0042475]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]; regulation of ion transmembrane transport [GO:0034765]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; sodium ion transmembrane transport [GO:0035725]

drug:
DB01086;DB00297;DB01161;DB00527;DB00907;DB00645;DB00473;DB06218;DB01002;DB00281;DB00961;DB01173;DB00892;DB00721;DB00807;DB00296;DB00313;

snps:
rs7630989 rs138404783 rs35332705 rs370208223 rs202174472 rs751574392 rs6795970 rs12632942 rs142173735 rs142217269 rs151090729 rs6599241 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO:0000250}.


uniprotID: Q96GD3
geneSymbol: SCMH1
pdb: 2P0K;
name: Polycomb protein SCMH1 (Sex comb on midleg homolog 1)
length: 660
go: ENSG00000010803;
drug: DB03345;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
chromocenter [GO:0010369]; nucleoplasm [GO:0005654]; anterior/posterior pattern specification [GO:0009952]; chromatin remodeling [GO:0006338]; gene silencing [GO:0016458]; negative regulation of transcription, DNA-templated [GO:0045892]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q96GD3-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=2; IsoId=Q96GD3-2; Sequence=VSP_051676, VSP_051679; Note=Gene prediction confirmed by EST data.; Name=3; IsoId=Q96GD3-3; Sequence=VSP_051678; Name=4 {ECO:0000269|PubMed:10524249}; IsoId=Q96GD3-4; Sequence=VSP_051677, VSP_051679; Name=5 {ECO:0000269|PubMed:10524249}; IsoId=Q96GD3-5; Sequence=VSP_051678, VSP_051679; Note=May be due to intron retention. {ECO:0000303|PubMed:10524249}; Name=6; IsoId=Q96GD3-6; Sequence=VSP_051677, VSP_043395, VSP_051679; Note=No experimental confirmation available.; 


uniprotID: Q9UN30
geneSymbol: SCML1
name: Sex comb on midleg-like protein 1
length: 329
go: ENSG00000047634;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; anatomical structure morphogenesis [GO:0009653]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=Q9UN30-3; Sequence=Displayed; Name=1; IsoId=Q9UN30-1; Sequence=VSP_037800; Name=2; IsoId=Q9UN30-2; Sequence=VSP_037801; 


uniprotID: Q9GZW5
geneSymbol: SCAND2P
name: Putative SCAN domain-containing protein SCAND2P (SCAN domain-containing protein 2 pseudogene)
length: 306
opentargets: nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]
snps: rs16974462 rs698620
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9GZW5-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9GZW5-2; Sequence=VSP_007110, VSP_007111; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q8IWT1
geneSymbol: SCN4B
reactome: R-HSA-445095;R-HSA-5576892;
pdb: 4MZ2;4MZ3;5XAW;
name: Sodium channel subunit beta-4
length: 228
go: ENSG00000177098;
drug: DB00313;DB00909;
snps: rs587777559 rs587777560 rs121434386
sequence:

opentargets:
intercalated disc [GO:0014704]; intrinsic component of plasma membrane [GO:0031226]; voltage-gated sodium channel complex [GO:0001518]; ion channel binding [GO:0044325]; sodium channel regulator activity [GO:0017080]; voltage-gated ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; AV node cell action potential [GO:0086016]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; positive regulation of sodium ion transport [GO:0010765]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IWT1-1; Sequence=Displayed; Name=2; IsoId=Q8IWT1-2; Sequence=VSP_053913; Note=No experimental confirmation available.; Name=3; IsoId=Q8IWT1-3; Sequence=VSP_046971; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.


uniprotID: Q14524
geneSymbol: SCN5A
reactome: R-HSA-445095;R-HSA-5576892;
pdb: 2KBI;2L53;4DCK;4DJC;4JQ0;4OVN;5DBR;
length: 2016
go: ENSG00000183873;
name:
Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)

sequence:

opentargets:
axon [GO:0030424]; caveola [GO:0005901]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; intercalated disc [GO:0014704]; intracellular [GO:0005622]; lateral plasma membrane [GO:0016328]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; T-tubule [GO:0030315]; voltage-gated sodium channel complex [GO:0001518]; Z disc [GO:0030018]; ankyrin binding [GO:0030506]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; ion channel binding [GO:0044325]; nitric-oxide synthase binding [GO:0050998]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; scaffold protein binding [GO:0097110]; ubiquitin protein ligase binding [GO:0031625]; voltage-gated ion channel activity [GO:0005244]; voltage-gated sodium channel activity [GO:0005248]; voltage-gated sodium channel activity involved in AV node cell action potential [GO:0086060]; voltage-gated sodium channel activity involved in bundle of His cell action potential [GO:0086061]; voltage-gated sodium channel activity involved in cardiac muscle cell action potential [GO:0086006]; voltage-gated sodium channel activity involved in Purkinje myocyte action potential [GO:0086062]; voltage-gated sodium channel activity involved in SA node cell action potential [GO:0086063]; atrial cardiac muscle cell action potential [GO:0086014]; AV node cell action potential [GO:0086016]; AV node cell to bundle of His cell communication [GO:0086067]; brainstem development [GO:0003360]; bundle of His cell action potential [GO:0086043]; cardiac muscle cell action potential involved in contraction [GO:0086002]; cardiac muscle contraction [GO:0060048]; cardiac ventricle development [GO:0003231]; cellular response to calcium ion [GO:0071277]; cerebellum development [GO:0021549]; membrane depolarization [GO:0051899]; membrane depolarization during action potential [GO:0086010]; membrane depolarization during atrial cardiac muscle cell action potential [GO:0098912]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during cardiac muscle cell action potential [GO:0086012]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; membrane depolarization during SA node cell action potential [GO:0086046]; neuronal action potential [GO:0019228]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of action potential [GO:0045760]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of sodium ion transport [GO:0010765]; regulation of atrial cardiac muscle cell membrane depolarization [GO:0060371]; regulation of atrial cardiac muscle cell membrane repolarization [GO:0060372]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of heart rate [GO:0002027]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of sodium ion transmembrane transport [GO:1902305]; regulation of ventricular cardiac muscle cell membrane depolarization [GO:0060373]; regulation of ventricular cardiac muscle cell membrane repolarization [GO:0060307]; response to denervation involved in regulation of muscle adaptation [GO:0014894]; SA node cell action potential [GO:0086015]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]; telencephalon development [GO:0021537]; ventricular cardiac muscle cell action potential [GO:0086005]

drug:
DB01426;DB01429;DB00868;DB00564;DB00527;DB00907;DB00280;DB01228;DB00754;DB01195;DB01320;DB00473;DB00192;DB00281;DB00532;DB00379;DB00680;DB00776;DB00252;DB00750;DB01035;DB01182;DB00908;DB01346;DB00243;DB00740;DB01056;DB00313;DB00661;DB00909;

snps:
rs199473043 rs41311087 rs199473044 rs199473045 rs199473551 rs6791924 rs199473046 rs199473047 rs199473048 rs199473553 rs199473049 rs199473050 rs199473051 rs199473052 rs199473053 rs199473054 rs199473055 rs199473554 rs199473055 rs199473056 rs199473057 rs199473058 rs199473556 rs199473059 rs185492581 rs199473557 rs199473060 rs199473061 rs199473062 rs199473062 rs199473063 rs199473065 rs199473066 rs199473067 rs199473558 rs199473559 rs199473070 rs199473070 rs41276525 rs45620037 rs45546039 rs199473560 rs199473071 rs199473072 rs199473561 rs199473074 rs45471994 rs199473076 rs199473077 rs199473078 rs199473079 rs199473080 rs199473081 rs199473562 rs199473082 rs199473083 rs61746118 rs199473084 rs199473563 rs199473086 rs137854608 rs199473087 rs199473088 rs199473564 rs199473090 rs199473091 rs199473092 rs199473093 rs199473094 rs199473095 rs199473095 rs199473096 rs199473565 rs199473097 rs28937318 rs28937318 rs199473098 rs199473099 rs199473566 rs199473100 rs199473101 rs199473567 rs199473102 rs199473103 rs199473104 rs199473105 rs199473107 rs199473108 rs199473568 rs199473109 rs72549410 rs199473569 rs199473110 rs199473111 rs199473570 rs199473112 rs199473113 rs199473571 rs41313697 rs199473114 rs199473572 rs199473115 rs199473116 rs144511230 rs199473117 rs199473118 rs137854606 rs41313691 rs45627438 rs199473120 rs199473573 rs199473121 rs199473122 rs3918389 rs1805124 rs199473124 rs199473125 rs199473576 rs199473126 rs36210423 rs184442491 rs36210423 rs199473127 rs199473128 rs199473130 rs199473131 rs199473132 rs12720452 rs45488304 rs199473133 rs199473577 rs199473134 rs199473135 rs199473578 rs199473136 rs199473137 rs185638763 rs45609733 rs199473138 rs199473579 rs41313681 rs199473139 rs199473140 rs199473141 rs199473142 rs199473143 rs199473144 rs199473580 rs199473145 rs45553235 rs199473147 rs199473148 rs199473149 rs199473150 rs137854611 rs137854611 rs199473582 rs199473152 rs199473153 rs199473154 rs199473156 rs199473157 rs199473158 rs199473159 rs199473160 rs199473584 rs199473162 rs199473164 rs199473166 rs199473586 rs199473167 rs199473168 rs199473587 rs199473169 rs199473170 rs199473171 rs199473172 rs199473173 rs199473174 rs199473175 rs199473588 rs199473176 rs199473177 rs199473589 rs199473178 rs199473179 rs137854605 rs199473590 rs199473180 rs199473181 rs199473181 rs61737825 rs199473591 rs41313667 rs137854609 rs137854609 rs199473183 rs199473185 rs199473592 rs763891399 rs199473186 rs45491996 rs137854617 rs199473593 rs199473187 rs199473188 rs199473189 rs199473190 rs1805125 rs199473191 rs199473192 rs7626962 rs199473193 rs199473194 rs199473195 rs199473196 rs199473197 rs199473199 rs199473594 rs41310765 rs41261344 rs199473202 rs199473597 rs199473204 rs199473205 rs199473598 rs199473206 rs199473207 rs199473208 rs199473210 rs199473211 rs199473599 rs199473213 rs45589741 rs199473600 rs199473214 rs137854616 rs199473601 rs137854618 rs199473216 rs199473217 rs41311127 rs199473218 rs28937319 rs199473603 rs41313031 rs199473219 rs199473220 rs199473221 rs28937317 rs199473222 rs199473224 rs199473224 rs199473225 rs199473604 rs199473226 rs199473227 rs199473228 rs199473229 rs199473230 rs199473231 rs199473232 rs199473233 rs199473234 rs199473235 rs199473236 rs199473237 rs199473608 rs199473239 rs199473239 rs199473609 rs199473240 rs137854612 rs199473610 rs199473241 rs199473242 rs199473611 rs199473244 rs199473612 rs199473245 rs199473246 rs199473247 rs199473248 rs199473249 rs199473250 rs199473251 rs199473613 rs199473252 rs199473253 rs199473614 rs199473254 rs199473255 rs199473256 rs199473257 rs199473615 rs199473258 rs199473259 rs199473616 rs199473260 rs199473261 rs199473262 rs199473263 rs199473264 rs199473265 rs199473266 rs199473267 rs199473268 rs137854602 rs199473617 rs199473269 rs199473270 rs199473618 rs199473271 rs199473619 rs199473273 rs199473274 rs199473620 rs199473275 rs45514691 rs199473621 rs199473276 rs199473277 rs137854607 rs199473278 rs199473280 rs199473622 rs199473281 rs199473282 rs199473282 rs137854600 rs137854600 rs199473283 rs199473283 rs199473623 rs199473624 rs199473287 rs28937316 rs199473288 rs199473289 rs199473290 rs199473291 rs199473291 rs199473625 rs199473292 rs199473293 rs199473626 rs199473294 rs1060499900 rs199473295 rs199473627 rs199473297 rs199473297 rs137854604 rs199473298 rs199473628 rs199473299 rs199473300 rs199473302 rs193922726 rs199473303 rs199473304 rs199473629 rs199473305 rs199473307 rs199473308 rs199473631 rs199473309 rs199473310 rs199473632 rs199473311 rs199473314 rs199473634 rs137854601 rs199473316 rs199473317 rs727504495 rs137854614 rs137854615 rs137854619 rs79299226 rs199473635 rs137854610 rs199473320 rs45563942 rs199473321 rs794728898 rs199473322 rs199473636 rs199473323 rs199473324 rs45465995 rs199473325 rs199473325 rs864622270 rs150264233 rs199473326 rs199473327 rs199473328 rs137854603 rs199473637 rs199473329 rs199473330 rs41315493 rs41315493 rs199473331 rs199473638 rs199473333 rs199473639 rs199473334 rs199473335 rs199473336 rs41311117 rs41311117 rs45489199 rs199473640 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=CAG-inclusive variant, Nav1.5c; IsoId=Q14524-1; Sequence=Displayed; Note=Most abundant isoform in heart.; Name=2; Synonyms=Nav1.5b; IsoId=Q14524-2; Sequence=VSP_037478; Note=Very abundant isoform.; Name=3; IsoId=Q14524-3; Sequence=VSP_037477, VSP_037478, VSP_037481; Name=4; Synonyms=Nav1.5e, neonatal; IsoId=Q14524-4; Sequence=VSP_037477; Note=Abundantly expressed in neonatal brain and heart, slower kinetics of activation and inactivation.; Name=5; Synonyms=Ex18del, Nav1.5a; IsoId=Q14524-5; Sequence=VSP_037477, VSP_037479; Note=Only detected in neuroblastoma in humans.; Name=6; Synonyms=Ex24del, Nav1.5f; IsoId=Q14524-6; Sequence=VSP_037477, VSP_037480; Note=High expression in brain where it accounts for nearly 50% of the total transcripts. Non-functional channel, may exist to limit the number of undesired functional Nav1.5 channels.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1309946, ECO:0000269|PubMed:19074138, ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23085483, ECO:0000269|PubMed:23420830, ECO:0000269|PubMed:25370050, ECO:0000269|PubMed:26279430}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21447824}. Note=RANGRF promotes trafficking to the cell membrane. {ECO:0000269|PubMed:21447824, ECO:0000269|PubMed:23420830}.


uniprotID: Q9UIL1
geneSymbol: SCOC
reactome: R-HSA-6811440;
pdb: 4BWD;
name: Short coiled-coil protein
length: 159
go: ENSG00000153130;
sequence:
MRRRVFSSQDWRASGWDGMGFFSRRTFCGRSGRSCRGQLVQVSRPEVSAGSLLLPAPQAEDHSSRILYPRPKSLLPKMMNADMDAVDAENQVELEEKTRLINQVLELQHTLEDLSARVDAVKEENLKLKSENQVLGQYIENLMSASSVFQTTDTKSKRK

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; positive regulation of macroautophagy [GO:0016239]; regulation of protein complex stability [GO:0061635]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UIL1-1; Sequence=Displayed; Name=2; IsoId=Q9UIL1-2; Sequence=VSP_033642, VSP_033643; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=Q9UIL1-3; Sequence=VSP_033642, VSP_033643, VSP_033645; Note=No experimental confirmation available.; Name=4; IsoId=Q9UIL1-4; Sequence=VSP_033644; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:22354037, ECO:0000269|PubMed:24098481}; Peripheral membrane protein {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:24098481}; Cytoplasmic side {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:24098481}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22354037}. Cytoplasm, cytosol {ECO:0000269|PubMed:11303027, ECO:0000269|PubMed:24098481}.


uniprotID: Q8NBX0
geneSymbol: SCCPDH
reactome: R-HSA-114608;
name: Saccharopine dehydrogenase-like oxidoreductase (EC 1.-.-.-)
length: 429
go: ENSG00000143653;
snps: rs7779
sequence:

opentargets:
extracellular region [GO:0005576]; lipid droplet [GO:0005811]; membrane [GO:0016020]; midbody [GO:0030496]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; oxidoreductase activity [GO:0016491]; glycolipid biosynthetic process [GO:0009247]; platelet degranulation [GO:0002576]


uniprotID: P62308
geneSymbol: SNRPG
reactome: R-HSA-109688;R-HSA-111367;R-HSA-191859;R-HSA-72163;R-HSA-72165;R-HSA-77588;
pdb: 3CW1;3JCR;3PGW;4F7U;4PJO;4V98;4WZJ;5MQF;5O9Z;5XJC;5XJL;5XJQ;5XJR;5XJT;5XJU;5YZG;5Z56;5Z57;5Z58;
name: Small nuclear ribonucleoprotein G (snRNP-G) (Sm protein G) (Sm-G) (SmG)
sequence: MSKAHPPELKKFMDKKLSLKLNGGRHVQGILRGFDPFMNLVIDECVEMATSGQQNNIGMVVIRGNSIIMLEALERV
length: 76
go: ENSG00000143977;
opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; methylosome [GO:0034709]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P granule [GO:0043186]; small nuclear ribonucleoprotein complex [GO:0030532]; SMN-Sm protein complex [GO:0034719]; spliceosomal complex [GO:0005681]; U1 snRNP [GO:0005685]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U2-type prespliceosome [GO:0071004]; U4 snRNP [GO:0005687]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; U7 snRNP [GO:0005683]; RNA binding [GO:0003723]; histone mRNA metabolic process [GO:0008334]; import into nucleus [GO:0051170]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]; spliceosomal snRNP assembly [GO:0000387]; termination of RNA polymerase II transcription [GO:0006369]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.


uniprotID: Q9HBX9
geneSymbol: RXFP1
reactome: R-HSA-418555;R-HSA-444821;
pdb: 2JM4;2M7P;
length: 757
go: ENSG00000171509;
name:
Relaxin receptor 1 (Leucine-rich repeat-containing G-protein coupled receptor 7) (Relaxin family peptide receptor 1)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; metal ion binding [GO:0046872]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9HBX9-1; Sequence=Displayed; Name=2; Synonyms=LGR7.10; IsoId=Q9HBX9-2; Sequence=VSP_001984; Name=3; Synonyms=LGR7.1; IsoId=Q9HBX9-3; Sequence=VSP_029877, VSP_029878; Name=4; Synonyms=LGR7.2; IsoId=Q9HBX9-4; Sequence=VSP_029879; Name=5; IsoId=Q9HBX9-5; Sequence=VSP_054375, VSP_054376; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16051677}; Multi-pass membrane protein {ECO:0000269|PubMed:16051677}.


uniprotID: Q8WXD0
geneSymbol: RXFP2
reactome: R-HSA-418555;R-HSA-444821;
pdb: 2M96;
length: 754
go: ENSG00000133105;
snps: rs121918303 rs17076657
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Relaxin receptor 2 (G-protein coupled receptor 106) (G-protein coupled receptor affecting testicular descent) (Leucine-rich repeat-containing G-protein coupled receptor 8) (Relaxin family peptide receptor 2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; protein-hormone receptor activity [GO:0016500]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone-mediated signaling pathway [GO:0009755]; male gonad development [GO:0008584]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; oocyte maturation [GO:0001556]; positive regulation of cAMP-mediated signaling [GO:0043950]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WXD0-1; Sequence=Displayed; Name=2; IsoId=Q8WXD0-2; Sequence=VSP_042831; Note=No experimental confirmation available.; 


uniprotID: P48443
geneSymbol: RXRG
reactome: R-HSA-383280;R-HSA-5362517;
pdb: 2GL8;
length: 463
go: ENSG00000143171;
drug: DB00459;DB00210;DB00523;DB00307;DB00926;DB00755;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
name:
Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)

sequence:

opentargets:
nucleoplasm [GO:0005654]; 9-cis retinoic acid receptor activity [GO:0004886]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; steroid hormone receptor activity [GO:0003707]; zinc ion binding [GO:0008270]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription initiation from RNA polymerase II promoter [GO:0006367]


uniprotID: P19793
geneSymbol: RXRA
length: 462
go: ENSG00000186350;
drug: DB07863;DB00459;DB00210;DB00523;DB00307;DB00749;DB00926;DB08601;
snps: rs2234960 rs1805345 rs1805345 rs11542209
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11915042}.
reactome:
R-HSA-1368082;R-HSA-1368108;R-HSA-159418;R-HSA-192105;R-HSA-193368;R-HSA-193807;R-HSA-1989781;R-HSA-200425;R-HSA-204174;R-HSA-211976;R-HSA-2151201;R-HSA-2426168;R-HSA-381340;R-HSA-383280;R-HSA-400206;R-HSA-400253;R-HSA-4090294;R-HSA-5362517;R-HSA-5617472;

pdb:
1BY4;1DSZ;1FBY;1FM6;1FM9;1G1U;1G5Y;1K74;1LBD;1MV9;1MVC;1MZN;1R0N;1RDT;1RXR;1XLS;1XV9;1XVP;1YNW;2ACL;2NLL;2P1T;2P1U;2P1V;2ZXZ;2ZY0;3DZU;3DZY;3E00;3E94;3FAL;3FC6;3FUG;3H0A;3KWY;3NSP;3NSQ;3OAP;3OZJ;3PCU;3R29;3R2A;3R5M;3UVV;4CN2;4CN3;4CN5;4CN7;4J5W;4J5X;4K4J;4K6I;4M8E;4M8H;4N5G;4N8R;4NQA;4OC7;4POH;4POJ;4PP3;4PP5;4RFW;4RMC;4RMD;4RME;4ZO1;4ZSH;5EC9;5GYM;5JI0;5LYQ;5MJ5;5MK4;5MKJ;5MKU;5MMW;5TBP;5UAN;5Z12;

name:
Retinoic acid receptor RXR-alpha (Nuclear receptor subfamily 2 group B member 1) (Retinoid X receptor alpha)

sequence:

opentargets:
nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; receptor complex [GO:0043235]; RNA polymerase II transcription factor complex [GO:0090575]; 9-cis retinoic acid receptor activity [GO:0004886]; chromatin DNA binding [GO:0031490]; DBD domain binding [GO:0050692]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; LBD domain binding [GO:0050693]; nuclear receptor activity [GO:0004879]; nuclear receptor binding [GO:0016922]; peptide binding [GO:0042277]; protein heterodimerization activity [GO:0046982]; retinoic acid binding [GO:0001972]; retinoic acid receptor activity [GO:0003708]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; steroid hormone receptor activity [GO:0003707]; transcription coactivator activity [GO:0003713]; vitamin D receptor binding [GO:0042809]; zinc ion binding [GO:0008270]; bile acid and bile salt transport [GO:0015721]; camera-type eye development [GO:0043010]; cardiac muscle cell proliferation [GO:0060038]; cholesterol metabolic process [GO:0008203]; embryo implantation [GO:0007566]; in utero embryonic development [GO:0001701]; maternal placenta development [GO:0001893]; modulation by virus of host morphology or physiology [GO:0019048]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of translational initiation by iron [GO:0045994]; protein homotetramerization [GO:0051289]; regulation of branching involved in prostate gland morphogenesis [GO:0060687]; regulation of lipid metabolic process [GO:0019216]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; transcription initiation from RNA polymerase II promoter [GO:0006367]; ventricular cardiac muscle cell differentiation [GO:0055012]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; vitamin metabolic process [GO:0006766]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P19793-1; Sequence=Displayed; Name=2; IsoId=P19793-2; Sequence=VSP_056565; Note=No experimental confirmation available.; 


uniprotID: P31151
geneSymbol: S100A7
reactome: R-HSA-6798695;R-HSA-6799990;
pdb: 1PSR;2PSR;2WND;2WOR;2WOS;3PSR;4AQJ;
name: Protein S100-A7 (Psoriasin) (S100 calcium-binding protein A7)
length: 101
go: ENSG00000143556;
drug: DB04474;
snps: rs3014837
sequence:
MSNTQAERSIIGMIDMFHKYTRRDDKIEKPSLLTMMKENFPNFLSACDKKGTNYLADVFEKKDKNEDKKIDFSEFLSLLGDIATDYHKQSHGAAPCSGGSQ

opentargets:
azurophil granule lumen [GO:0035578]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; defense response to Gram-negative bacterium [GO:0050829]; epidermis development [GO:0008544]; innate immune response [GO:0045087]; keratinocyte differentiation [GO:0030216]; neutrophil degranulation [GO:0043312]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granulocyte chemotaxis [GO:0071624]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of T cell chemotaxis [GO:0010820]; response to lipopolysaccharide [GO:0032496]; response to reactive oxygen species [GO:0000302]; sequestering of metal ion [GO:0051238]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8618345}. Secreted {ECO:0000269|PubMed:8618345}. Note=Secreted by a non-classical secretory pathway.


uniprotID: P05109
geneSymbol: S100A8
reactome: R-HSA-5686938;R-HSA-6798695;R-HSA-6799990;
pdb: 1MR8;1XK4;4GGF;4XJK;5HLO;5HLV;5W1F;6DS2;
sequence: MLTELEKALNSIIDVYHKYSLIKGNFHAVYRDDLKKLLETECPQYIRKKGADVWFKELDINTDGAVNFQEFLILVIKMGVAAHKKSHEESHKE
length: 93
go: ENSG00000143546;
name:
Protein S100-A8 (Calgranulin-A) (Calprotectin L1L subunit) (Cystic fibrosis antigen) (CFAG) (Leukocyte L1 complex light chain) (Migration inhibitory factor-related protein 8) (MRP-8) (p8) (S100 calcium-binding protein A8) (Urinary stone protein band A)

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intermediate filament cytoskeleton [GO:0045111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; arachidonic acid binding [GO:0050544]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; RAGE receptor binding [GO:0050786]; Toll-like receptor 4 binding [GO:0035662]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; acute inflammatory response [GO:0002526]; antimicrobial humoral response [GO:0019730]; apoptotic process [GO:0006915]; astrocyte development [GO:0014002]; autophagy [GO:0006914]; chemokine production [GO:0032602]; chronic inflammatory response [GO:0002544]; cytokine production [GO:0001816]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; leukocyte migration involved in inflammatory response [GO:0002523]; neutrophil aggregation [GO:0070488]; neutrophil chemotaxis [GO:0030593]; neutrophil degranulation [GO:0043312]; peptidyl-cysteine S-nitrosylation [GO:0018119]; positive regulation of cell growth [GO:0030307]; positive regulation of inflammatory response [GO:0050729]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of peptide secretion [GO:0002793]; regulation of cytoskeleton organization [GO:0051493]; response to ethanol [GO:0045471]; response to lipopolysaccharide [GO:0032496]; response to zinc ion [GO:0010043]; sequestering of zinc ion [GO:0032119]; toll-like receptor signaling pathway [GO:0002224]; wound healing [GO:0042060]

location:
SUBCELLULAR LOCATION: Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation or endothelial adhesion of monocytes, is secreted via a microtubule-mediated, alternative pathway.


uniprotID: P29377
geneSymbol: S100G
sequence: MSTKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEFPSLLKGPNTLDDLFQELDKNGDGEVSFEEFQVLVKKISQ
length: 79
go: ENSG00000169906;
drug: DB04464;
name:
Protein S100-G (Calbindin-D9k) (S100 calcium-binding protein G) (Vitamin D-dependent calcium-binding protein, intestinal) (CABP)

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]; vitamin D binding [GO:0005499]


uniprotID: P25815
geneSymbol: S100P
reactome: R-HSA-6798695;
pdb: 1J55;1OZO;2MJW;
sequence: MTELETAMGMIIDVFSRYSGSEGSTQTLTKGELKVLMEKELPGFLQSGKDKDAVDKLLKDLDANGDAQVDFSEFIVFVAAITSACHKYFEKAGLK
length: 95
go: ENSG00000163993;
drug: DB01003;
name:
Protein S100-P (Migration-inducing gene 9 protein) (MIG9) (Protein S100-E) (S100 calcium-binding protein P)

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; microvillus membrane [GO:0031528]; nuclear body [GO:0016604]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; transition metal ion binding [GO:0046914]; endothelial cell migration [GO:0043542]; neutrophil degranulation [GO:0043312]; response to organic substance [GO:0010033]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium-dependent manner.


uniprotID: P23297
geneSymbol: S100A1
reactome: R-HSA-5686938;
pdb: 2L0P;2LHL;2LLS;2LLT;2LLU;2LP2;2LP3;2LUX;2M3W;5K89;
sequence: MGSELETAMETLINVFHAHSGKEGDKYKLSKKELKELLQTELSGFLDAQKDVDAVDKVMKELDENGDGEVDFQEYVVLVAALTVACNNFFWENS
length: 94
go: ENSG00000160678;
drug: DB00768;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15171681}.
name:
Protein S100-A1 (S-100 protein alpha chain) (S-100 protein subunit alpha) (S100 calcium-binding protein A1)

opentargets:
extracellular region [GO:0005576]; M band [GO:0031430]; neuron projection [GO:0043005]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; sarcoplasmic reticulum [GO:0016529]; Z disc [GO:0030018]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; intracellular signal transduction [GO:0035556]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; regulation of heart contraction [GO:0008016]; substantia nigra development [GO:0021762]; toll-like receptor signaling pathway [GO:0002224]


uniprotID: P55017
geneSymbol: SLC12A3
reactome: R-HSA-426117;R-HSA-5619087;
length: 1021
go: ENSG00000070915;
drug: DB00436;DB00562;DB00880;DB01119;DB00999;DB00524;DB01324;DB01325;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22009145}; Multi-pass membrane protein.
name:
Solute carrier family 12 member 3 (Na-Cl cotransporter) (NCC) (Na-Cl symporter) (Thiazide-sensitive sodium-chloride cotransporter)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; potassium:chloride symporter activity [GO:0015379]; sodium ion transmembrane transporter activity [GO:0015081]; sodium:chloride symporter activity [GO:0015378]; sodium:potassium:chloride symporter activity [GO:0008511]; transporter activity [GO:0005215]; cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import [GO:0010107]; sodium ion transmembrane transport [GO:0035725]; sodium ion transport [GO:0006814]

snps:
rs371443644 rs757490496 rs763210286 rs780502516 rs768527231 rs201255508 rs146632606 rs749742102 rs148945966 rs374324018 rs143714318 rs779074538 rs748547209 rs775047246 rs1274973729 rs267607050 rs779683214 rs757792232 rs772589653 rs146158333 rs759426055 rs1231715433 rs758035631 rs28936388 rs780594361 rs774753202 rs375990084 rs780461639 rs914588619 rs1529927 rs568513106 rs755069436 rs753840283 rs140551719 rs748920885 rs150046661 rs770702194 rs121909383 rs773669504 rs187885782 rs748575829 rs775931992 rs28936387 rs759377924 rs374163823 rs201945662 rs373017321 rs753523115 rs777612082 rs369510226 rs781137708 rs780433336 rs748650798 rs574357286 rs148038173 rs79351185 rs139329616 rs121909382 rs1222807128 rs779160677 rs779160677 rs121909385 rs121909384 rs200697179 rs200697179 rs147901432 rs140012781 rs747249619 rs121909380 rs121909380 rs771326058 rs36049418 rs373901523 rs752101663 rs757761069 rs138977195 rs368068353 rs146845953 rs185927948 rs121909379 rs373899077 rs751929135 rs8060046 rs754505583 rs370301695 rs752124879 rs369360334 rs11643718 rs12708965 rs201721269 rs56125220 rs202114767 rs773428143 rs34803727 rs199849117 rs370175770 rs762026283 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P55017-1; Sequence=Displayed; Name=2; IsoId=P55017-2; Sequence=VSP_036318; Name=3; IsoId=P55017-3; Sequence=VSP_040100, VSP_036318; Note=No experimental confirmation available.; 


uniprotID: P29034
geneSymbol: S100A2
pdb: 2RGI;4DUQ;
name: Protein S100-A2 (CAN19) (Protein S-100L) (S100 calcium-binding protein A2)
sequence: MMCSSLEQALAVLVTTFHKYSCQEGDKFKLSKGEMKELLHKELPSFVGEKVDEEGLKKLMGSLDENSDQQVDFQEYAVFLALITVMCNDFFQGCPDRP
length: 98
drug: DB00768;
opentargets:
calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; transition metal ion binding [GO:0046914]; endothelial cell migration [GO:0043542]


uniprotID: Q9H2X9
geneSymbol: SLC12A5
reactome: R-HSA-426117;
length: 1139
go: ENSG00000124140;
drug: DB00887;DB00761;
snps: rs863225306 rs16985442 rs863225304 rs863225305 rs142740233 rs369042030 rs548424453 rs17297532
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)

sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; chloride transmembrane transporter activity [GO:0015108]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; cell volume homeostasis [GO:0006884]; cellular chloride ion homeostasis [GO:0030644]; cellular ion homeostasis [GO:0006873]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; dendritic spine development [GO:0060996]; hypotonic response [GO:0006971]; ion transport [GO:0006811]; learning [GO:0007612]; multicellular organism growth [GO:0035264]; potassium ion homeostasis [GO:0055075]; potassium ion import [GO:0010107]; response to drug [GO:0042493]; thermosensory behavior [GO:0040040]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=KCC2a; IsoId=Q9H2X9-1; Sequence=Displayed; Name=2; Synonyms=KCC2b; IsoId=Q9H2X9-2; Sequence=VSP_029909; 


uniprotID: P33763
geneSymbol: S100A5
pdb: 2KAX;2KAY;4DIR;
name: Protein S100-A5 (Protein S-100D) (S100 calcium-binding protein A5)
sequence: METPLEKALTTMVTTFHKYSGREGSKLTLSRKELKELIKKELCLGEMKESSIDDLMKSLDKNSDQEIDFKEYSVFLTMLCMAYNDFFLEDNK
length: 92
go: ENSG00000196420;
snps: rs3795393
opentargets:
neuronal cell body [GO:0043025]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; protein homodimerization activity [GO:0042803]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P33763-1; Sequence=Displayed; Name=2; IsoId=P33763-2; Sequence=VSP_055506; Note=No experimental confirmation available.; 


uniprotID: Q9UHW9
geneSymbol: SLC12A6
reactome: R-HSA-426117;R-HSA-5619039;
length: 1150
go: ENSG00000140199;
drug: DB00761;
snps: rs2705339
name:
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; potassium ion transmembrane transporter activity [GO:0015079]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; angiogenesis [GO:0001525]; cell volume homeostasis [GO:0006884]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; chemical synaptic transmission [GO:0007268]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; ion transport [GO:0006811]; potassium ion homeostasis [GO:0055075]; potassium ion import [GO:0010107]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=6;  Name=1; Synonyms=KCC3a; IsoId=Q9UHW9-1; Sequence=Displayed; Name=2; Synonyms=KCC3b; IsoId=Q9UHW9-2; Sequence=VSP_006115, VSP_006116; Note=Produced by alternative promoter usage.; Name=3; Synonyms=KCC3a-X2M; IsoId=Q9UHW9-3; Sequence=VSP_041389; Note=Does not differ in the osmotic set point of swelling activation but, activation is more rapid.; Name=4; Synonyms=KCC3a-S3; IsoId=Q9UHW9-4; Sequence=VSP_041388; Name=5; Synonyms=KCC3a-S, KCC3a-S1, KCC3a-S2; IsoId=Q9UHW9-5; Sequence=VSP_041387; Note=Does not differ in the osmotic set point of swelling activation but, activation is more rapid.; Name=6; Synonyms=KCC3b-X2M; IsoId=Q9UHW9-6; Sequence=VSP_006115, VSP_006116, VSP_041389; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q9HCY8
geneSymbol: S100A14
pdb: 2M0R;
name: Protein S100-A14 (S100 calcium-binding protein A14) (S114)
length: 104
go: ENSG00000189334;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11944983}.
sequence:
MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGSCNDSKLEFRSFWELIGEAAKSVKLERPVRGH

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; chemokine receptor binding [GO:0042379]; apoptotic process [GO:0006915]; calcium ion homeostasis [GO:0055074]; defense response to bacterium [GO:0042742]; positive regulation of granulocyte chemotaxis [GO:0071624]; positive regulation of monocyte chemotaxis [GO:0090026]; response to lipopolysaccharide [GO:0032496]; toll-like receptor 4 signaling pathway [GO:0034142]


uniprotID: Q8IY34
geneSymbol: SLC15A3
reactome: R-HSA-427975;
length: 581
go: ENSG00000110446;
snps: rs17855607
name:
Solute carrier family 15 member 3 (Osteoclast transporter) (Peptide transporter 3) (Peptide/histidine transporter 2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; oligopeptide transmembrane transporter activity [GO:0035673]; peptide transmembrane transporter activity [GO:1904680]; peptide:proton symporter activity [GO:0015333]; ion transport [GO:0006811]; protein transport [GO:0015031]

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}.


uniprotID: Q9Y2C5
geneSymbol: SLC17A4
name: Probable small intestine urate exporter (Solute carrier family 17 member 4)
length: 497
go: ENSG00000146039;
snps: rs11754288
sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; lysosome [GO:0005764]; membrane [GO:0016020]; sialic acid transmembrane transporter activity [GO:0015136]; sodium:phosphate symporter activity [GO:0005436]; phosphate-containing compound metabolic process [GO:0006796]; sialic acid transport [GO:0015739]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9Y2C5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2C5-2; Sequence=VSP_031178; Name=3; IsoId=Q9Y2C5-3; Sequence=VSP_054938; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y2C5-4; Sequence=VSP_031178, VSP_054939, VSP_054940, VSP_054941; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000269|PubMed:22460716}. Cell membrane {ECO:0000269|PubMed:22460716}; Multi-pass membrane protein {ECO:0000269|PubMed:22460716}. Note=Apical in the intestinal brush border.


uniprotID: Q8WWT9
geneSymbol: SLC13A3
reactome: R-HSA-433137;
length: 602
go: ENSG00000158296;
drug: DB00139;
name:
Solute carrier family 13 member 3 (Na(+)/dicarboxylate cotransporter 3) (NaDC-3) (hNaDC3) (Sodium-dependent high-affinity dicarboxylate transporter 2)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; citrate transmembrane transporter activity [GO:0015137]; high-affinity sodium:dicarboxylate symporter activity [GO:0015362]; sodium:dicarboxylate symporter activity [GO:0017153]; succinate transmembrane transporter activity [GO:0015141]; citrate transport [GO:0015746]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q8WWT9-1; Sequence=Displayed; Name=2; IsoId=Q8WWT9-2; Sequence=VSP_006123, VSP_006124; Note=Gene prediction based on EST data.; Name=3; IsoId=Q8WWT9-3; Sequence=VSP_015291, VSP_015293; Note=No experimental confirmation available.; Name=4; IsoId=Q8WWT9-4; Sequence=VSP_015292, VSP_015294, VSP_015295; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=5; IsoId=Q8WWT9-5; Sequence=VSP_015292; Note=No experimental confirmation available.; Name=6; IsoId=Q8WWT9-6; Sequence=VSP_015291; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17426067}; Multi-pass membrane protein {ECO:0000269|PubMed:17426067}.


uniprotID: P21453
geneSymbol: S1PR1
reactome: R-HSA-418594;R-HSA-419408;R-HSA-6785807;
pdb: 3V2W;3V2Y;
length: 382
go: ENSG00000170989;
drug: DB09105;
snps: rs4987250 rs11542632 rs7549921
name:
Sphingosine 1-phosphate receptor 1 (S1P receptor 1) (S1P1) (Endothelial differentiation G-protein coupled receptor 1) (Sphingosine 1-phosphate receptor Edg-1) (S1P receptor Edg-1) (CD antigen CD363)

sequence:

opentargets:
endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; intrinsic component of plasma membrane [GO:0031226]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; sphingolipid binding [GO:0046625]; sphingosine-1-phosphate receptor activity [GO:0038036]; actin cytoskeleton reorganization [GO:0031532]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; angiogenesis [GO:0001525]; blood vessel maturation [GO:0001955]; brain development [GO:0007420]; cardiac muscle tissue growth involved in heart morphogenesis [GO:0003245]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; endothelial cell differentiation [GO:0045446]; G protein-coupled receptor signaling pathway [GO:0007186]; heart trabecula morphogenesis [GO:0061384]; lamellipodium assembly [GO:0030032]; leukocyte chemotaxis [GO:0030595]; negative regulation of stress fiber assembly [GO:0051497]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway [GO:0051482]; positive regulation of GTPase activity [GO:0043547]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of bone mineralization [GO:0030500]; regulation of bone resorption [GO:0045124]; regulation of cell adhesion [GO:0030155]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell migration [GO:0072678]; transmission of nerve impulse [GO:0019226]

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.


uniprotID: Q9BYT1
geneSymbol: SLC17A9
name: Solute carrier family 17 member 9
length: 436
go: ENSG00000101194;
snps: rs548728088 rs2427463 rs606231251 rs7271712
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; transporter activity [GO:0005215]; exocytosis [GO:0006887]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BYT1-1; Sequence=Displayed; Name=2; IsoId=Q9BYT1-2; Sequence=VSP_010344; Name=3; IsoId=Q9BYT1-3; Sequence=VSP_010345, VSP_010346; Note=No experimental confirmation available.; 


uniprotID: O95136
geneSymbol: S1PR2
reactome: R-HSA-418594;R-HSA-419408;
pdb: 1ZTI;
length: 353
go: ENSG00000267534;
snps: rs869312749 rs869312750
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Sphingosine 1-phosphate receptor 2 (S1P receptor 2) (S1P2) (Endothelial differentiation G-protein coupled receptor 5) (Sphingosine 1-phosphate receptor Edg-5) (S1P receptor Edg-5)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor binding [GO:0001664]; integrin binding [GO:0005178]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]; actin cytoskeleton reorganization [GO:0031532]; activation of MAPK activity [GO:0000187]; filopodium assembly [GO:0046847]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of excitatory postsynaptic potential [GO:0090394]; positive regulation of cell proliferation [GO:0008284]; positive regulation of establishment of endothelial barrier [GO:1903142]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]


uniprotID: Q9UDX4
geneSymbol: SEC14L3
pdb: 4UYB;
name: SEC14-like protein 3 (Tocopherol-associated protein 2)
length: 400
go: ENSG00000100012;
opentargets: extracellular exosome [GO:0070062]; lipid binding [GO:0008289]
drug: DB00163;
snps: rs4820853 rs2269961 rs2240345 rs35764129
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UDX4-1; Sequence=Displayed; Name=2; IsoId=Q9UDX4-2; Sequence=VSP_045554; Note=No experimental confirmation available.; Name=3; IsoId=Q9UDX4-3; Sequence=VSP_045553; Note=No experimental confirmation available.; 


uniprotID: O15244
geneSymbol: SLC22A2
reactome: R-HSA-112311;R-HSA-181430;R-HSA-2161517;R-HSA-442660;R-HSA-549127;
name: Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2)
length: 555
go: ENSG00000112499;
snps: rs8177504 rs8177507 rs145450955 rs316019 rs8177513 rs8177516 rs8177517 rs3907239
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; neurotransmitter transporter activity [GO:0005326]; organic cation transmembrane transporter activity [GO:0015101]; body fluid secretion [GO:0007589]; drug transmembrane transport [GO:0006855]; neurotransmitter biosynthetic process [GO:0042136]; neurotransmitter secretion [GO:0007269]; organic cation transport [GO:0015695]

drug:
DB08838;DB00915;DB00594;DB02533;DB00345;DB01114;DB00122;DB00501;DB00515;DB00242;DB00907;DB00987;DB00694;DB01151;DB09555;DB01160;DB00917;DB01075;DB00280;DB00988;DB00668;DB00783;DB00927;DB00690;DB00365;DB00536;DB05381;DB00619;DB00458;DB00709;DB01137;DB01043;DB00331;DB00264;DB00184;DB00368;DB00526;DB01580;DB01337;DB00914;DB00925;DB00413;DB00457;DB01032;DB01035;DB00396;DB00571;DB01103;DB00908;DB00468;DB00206;DB08837;DB00152;DB01199;DB00570;DB00495;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O15244-1; Sequence=Displayed; Name=2; Synonyms=OCT2-A; IsoId=O15244-2; Sequence=VSP_031773, VSP_031774; Name=3; IsoId=O15244-3; Sequence=VSP_031771, VSP_031772; Note=No experimental confirmation available.; 


uniprotID: O95977
geneSymbol: S1PR4
reactome: R-HSA-418594;R-HSA-419408;
pdb: 2DCO;
length: 384
go: ENSG00000125910;
snps: rs3746072
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Sphingosine 1-phosphate receptor 4 (S1P receptor 4) (S1P4) (Endothelial differentiation G-protein coupled receptor 6) (Sphingosine 1-phosphate receptor Edg-6) (S1P receptor Edg-6)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; lipid binding [GO:0008289]; sphingosine-1-phosphate receptor activity [GO:0038036]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; positive regulation of cytosolic calcium ion concentration [GO:0007204]


uniprotID: Q9UHA2
geneSymbol: SS18L2
name: SS18-like protein 2 (SYT homolog 2)
sequence: MSVAFVPDWLRGKAEVNQETIQRLLEENDQLIRCIVEYQNKGRGNECVQYQHVLHRNLIYLATIADASPTSTSKAME
length: 77
go: ENSG00000008324;
opentargets:
nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]


uniprotID: Q9H015
geneSymbol: SLC22A4
reactome: R-HSA-549127;
length: 551
go: ENSG00000197208;
snps: rs272893 rs4646201 rs1050152
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Solute carrier family 22 member 4 (Ergothioneine transporter) (ET transporter) (Organic cation/carnitine transporter 1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of plasma membrane [GO:0005887]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; cation:cation antiporter activity [GO:0015491]; nucleotide binding [GO:0000166]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; secondary active organic cation transmembrane transporter activity [GO:0008513]; symporter activity [GO:0015293]; body fluid secretion [GO:0007589]; carnitine metabolic process [GO:0009437]; carnitine transport [GO:0015879]; organic cation transport [GO:0015695]; quaternary ammonium group transport [GO:0015697]; sodium ion transport [GO:0006814]; triglyceride metabolic process [GO:0006641]

drug:
DB00594;DB00345;DB01053;DB00122;DB00501;DB00575;DB01151;DB00536;DB00458;DB00332;DB00125;DB00583;DB00123;DB01137;DB06691;DB00184;DB01165;DB01035;DB01917;DB00908;DB00468;DB03566;DB00127;DB00624;DB08837;DB01409;DB00661;


uniprotID: O76082
geneSymbol: SLC22A5
reactome: R-HSA-200425;R-HSA-549127;R-HSA-5619053;
length: 557
go: ENSG00000197375;
name:
Solute carrier family 22 member 5 (High-affinity sodium-dependent carnitine cotransporter) (Organic cation/carnitine transporter 2)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; carnitine transmembrane transporter activity [GO:0015226]; drug transmembrane transporter activity [GO:0015238]; PDZ domain binding [GO:0030165]; quaternary ammonium group transmembrane transporter activity [GO:0015651]; symporter activity [GO:0015293]; carnitine transmembrane transport [GO:1902603]; carnitine transport [GO:0015879]; drug transport [GO:0015893]; positive regulation of intestinal epithelial structure maintenance [GO:0060731]; quaternary ammonium group transport [GO:0015697]; quorum sensing involved in interaction with host [GO:0052106]; sodium ion transport [GO:0006814]; sodium-dependent organic cation transport [GO:0070715]

drug:
DB08842;DB03128;DB04630;DB00345;DB00182;DB00415;DB08795;DB01053;DB01140;DB00456;DB00535;DB01413;DB00671;DB01333;DB00438;DB00567;DB00689;DB00122;DB00501;DB00575;DB00148;DB01000;DB00970;DB04133;DB01151;DB01075;DB00988;DB00668;DB00695;DB00365;DB00536;DB05381;DB00332;DB00125;DB00583;DB00281;DB00978;DB06691;DB01577;DB00627;DB00184;DB00368;DB01059;DB01165;DB01032;DB01035;DB00908;DB00468;DB01208;DB08837;DB00152;DB01409;DB00313;DB00661;

snps:
rs139203363 rs267607052 rs11568520 rs72552723 rs144020613 rs772578415 rs72552724 rs72552725 rs199689597 rs377767445 rs202088921 rs757711838 rs72552726 rs386134190 rs386134191 rs377767450 rs386134192 rs201082652 rs748605096 rs151231558 rs10040427 rs386134193 rs121908889 rs121908890 rs781721860 rs145068530 rs386134196 rs386134197 rs386134198 rs121908888 rs386134199 rs386134205 rs185551386 rs756650860 rs386134206 rs114269482 rs72552728 rs200699819 rs386134203 rs201262157 rs201262157 rs386134208 rs386134210 rs386134211 rs72552729 rs72552730 rs77300588 rs774792831 rs150544263 rs68018207 rs1385634398 rs61731073 rs886042092 rs386134214 rs144547521 rs121908891 rs267607054 rs72552732 rs267607053 rs72552733 rs386134218 rs386134219 rs11568514 rs72552734 rs60376624 rs386134221 rs386134222 rs749282641 rs386134223 rs72552735 rs11568513 rs11568513 rs377216516 rs28383481 rs11568521 rs11568524 rs11568525 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O76082-1; Sequence=Displayed; Name=2; IsoId=O76082-2; Sequence=VSP_011120, VSP_011121; Note=No experimental confirmation available.; Name=3; Synonyms=OCTN2VT; IsoId=O76082-3; Sequence=VSP_043904; Note=Retained in the ER, unable to perform carnitine uptake.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10679939}; Multi-pass membrane protein {ECO:0000269|PubMed:10679939}.


uniprotID: Q08357
geneSymbol: SLC20A2
reactome: R-HSA-427652;R-HSA-5619111;
length: 652
go: ENSG00000168575;
name:
Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; inorganic phosphate transmembrane transporter activity [GO:0005315]; signaling receptor activity [GO:0038023]; sodium-dependent phosphate transmembrane transporter activity [GO:0015321]; sodium:inorganic phosphate symporter activity [GO:0015319]; sodium:phosphate symporter activity [GO:0005436]; virus receptor activity [GO:0001618]; ion transport [GO:0006811]; phosphate ion transmembrane transport [GO:0035435]

snps:
rs201836672 rs775911275 rs748252183 rs200010919 rs1357615935 rs763252801 rs1388992742 rs387906653 rs387906654 rs387906652 rs387906652 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9151850}; Multi-pass membrane protein {ECO:0000269|PubMed:9151850}.


uniprotID: Q86SG5
geneSymbol: S100A7A
reactome: R-HSA-6799990;
pdb: 4AQI;
length: 101
go: ENSG00000184330;
snps: rs55985140 rs3006414
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Protein S100-A7A (S100 calcium-binding protein A15) (S100 calcium-binding protein A7-like 1) (S100 calcium-binding protein A7A)

sequence:
MSNTQAERSIIGMIDMFHKYTGRDGKIEKPSLLTMMKENFPNFLSACDKKGIHYLATVFEKKDKNEDKKIDFSEFLSLLGDIAADYHKQSHGAAPCSGGSQ

opentargets:
cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]; protein self-association [GO:0043621]; transition metal ion binding [GO:0046914]


uniprotID: Q5SY68
geneSymbol: S100A7L2
name: Protein S100-A7-like 2 (S100 calcium-binding protein A7-like 2)
length: 101
sequence:
MNIPLGEKVMLDIVAMFRQYSGDDGRMDMPGLVNLMKENFPNFLSGCEKSDMDYLSNALEKKDDNKDKKVNYSEFLSLLGDITIDHHKIMHGVAPCSGGSQ

opentargets:
extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]


uniprotID: Q96BI1
geneSymbol: SLC22A18
reactome: R-HSA-549127;R-HSA-5619066;
length: 424
go: ENSG00000110628;
snps: rs1048046 rs1048047 rs121909071 rs141165353 rs1129782
name:
Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; drug transmembrane transporter activity [GO:0015238]; drug:proton antiporter activity [GO:0015307]; symporter activity [GO:0015293]; ubiquitin protein ligase binding [GO:0031625]; drug transport [GO:0015893]; excretion [GO:0007588]; organic cation transport [GO:0015695]

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localized at the apical membrane surface of renal proximal tubules. {ECO:0000269|PubMed:9744804}.


uniprotID: Q6T423
geneSymbol: SLC22A25
name: Solute carrier family 22 member 25 (Organic anion transporter UST6)
length: 547
go: ENSG00000196600;
opentargets: integral component of membrane [GO:0016021]; transmembrane transport [GO:0055085]
snps: rs35722529 rs11231409 rs11231397 rs17157907 rs6591771
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: Q9BZJ4
geneSymbol: SLC25A39
name: Solute carrier family 25 member 39
length: 359
go: ENSG00000013306;
snps: rs2011951
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; heme biosynthetic process [GO:0006783]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=CGI-69L; IsoId=Q9BZJ4-1; Sequence=Displayed; Name=2; IsoId=Q9BZJ4-2; Sequence=VSP_003264; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11139402, ECO:0000269|PubMed:11256614}; Multi-pass membrane protein {ECO:0000269|PubMed:11139402, ECO:0000269|PubMed:11256614}.


uniprotID: Q8TBP6
geneSymbol: SLC25A40
name: Solute carrier family 25 member 40 (Mitochondrial carrier family protein)
length: 338
go: ENSG00000075303;
snps: rs200954020 rs724665 rs3213633
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; transmembrane transporter activity [GO:0022857]


uniprotID: Q3KQZ1
geneSymbol: SLC25A35
name: Solute carrier family 25 member 35
length: 300
go: ENSG00000125434;
opentargets: integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q3KQZ1-1; Sequence=Displayed; Name=2; IsoId=Q3KQZ1-2; Sequence=VSP_026239; Name=3; IsoId=Q3KQZ1-3; Sequence=VSP_026238, VSP_026239; Name=4; IsoId=Q3KQZ1-4; Sequence=VSP_026237; 


uniprotID: Q9BXS9
geneSymbol: SLC26A6
reactome: R-HSA-427601;
length: 759
go: ENSG00000225697;
snps: rs13324142
name:
Solute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; brush border membrane [GO:0031526]; chloride channel complex [GO:0034707]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; vesicle [GO:0031982]; vesicle membrane [GO:0012506]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; efflux transmembrane transporter activity [GO:0015562]; formate efflux transmembrane transporter activity [GO:0015660]; formate transmembrane transporter activity [GO:0015499]; inorganic anion exchanger activity [GO:0005452]; oxalate transmembrane transporter activity [GO:0019531]; PDZ domain binding [GO:0030165]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; angiotensin-activated signaling pathway [GO:0038166]; bicarbonate transport [GO:0015701]; cellular response to cAMP [GO:0071320]; cellular response to fructose stimulus [GO:0071332]; cellular response to interferon-gamma [GO:0071346]; chloride transport [GO:0006821]; epithelial fluid transport [GO:0042045]; formate transport [GO:0015724]; intestinal absorption [GO:0050892]; intracellular pH elevation [GO:0051454]; ion transport [GO:0006811]; mannitol transport [GO:0015797]; oxalate transport [GO:0019532]; oxalic acid secretion [GO:0046724]; positive regulation of dipeptide transmembrane transport [GO:2001150]; protein kinase C signaling [GO:0070528]; regulation of intracellular pH [GO:0051453]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]; sulfate transport [GO:0008272]; transepithelial chloride transport [GO:0030321]; transepithelial transport [GO:0070633]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=SLC26A6b; IsoId=Q9BXS9-1; Sequence=Displayed; Name=2; IsoId=Q9BXS9-2; Sequence=VSP_006169; Note=No experimental confirmation available.; Name=3; IsoId=Q9BXS9-3; Sequence=VSP_040127; Name=4; Synonyms=SLC26A6a; IsoId=Q9BXS9-4; Sequence=VSP_046807, VSP_040127; Name=5; Synonyms=SLC26A6c; IsoId=Q9BXS9-5; Sequence=VSP_046807, VSP_047851, VSP_040127; Name=6; Synonyms=SLC26A6d; IsoId=Q9BXS9-6; Sequence=VSP_046807, VSP_047852; Name=7; IsoId=Q9BXS9-7; Sequence=VSP_055273, VSP_055274; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Microsome {ECO:0000250}. Note=Localized in sperm membranes. Colocalizes with CFTR at the midpiece of sperm tail. Localizes to the apical membrane brush border of epithelial cells in the proximal tubules of kidney, of enterocytes of the small intestine and of gastric parietal cells in the stomach. May be translocated from the cytosolic surface of the cell membrane to the intracellular space by PKC in phorbol myristate acetate (PMA)-induced cells (By similarity). Colocalized with CA2 at the surface of the cell membrane in order to form a bicarbonate transport metabolon; colocalization is reduced in phorbol myristate acetate (PMA)-induced cells. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 4: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Note=Localizes to the apical and basolateral surfaces of tubular wall cells in kidney and in the brush border of pancreatic duct cells.; SUBCELLULAR LOCATION: Isoform 5: Cell membrane; Multi-pass membrane protein.; SUBCELLULAR LOCATION: Isoform 6: Cell membrane; Multi-pass membrane protein.


uniprotID: Q6ZT89
geneSymbol: SLC25A48
name: Solute carrier family 25 member 48
length: 311
go: ENSG00000145832;
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; acyl carnitine transmembrane transporter activity [GO:0015227]; acyl carnitine transport [GO:0006844]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZT89-1; Sequence=Displayed; Note=Gene prediction based on similarity to bovine ortholog.; Name=2; IsoId=Q6ZT89-2; Sequence=VSP_032399; Name=3; IsoId=Q6ZT89-3; Sequence=VSP_032397, VSP_032398; 


uniprotID: Q9UHR5
geneSymbol: SAP30BP
reactome: R-HSA-427413;
name: SAP30-binding protein (Transcriptional regulator protein HCNGP)
length: 308
go: ENSG00000161526;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15496587}.
sequence:

opentargets:
intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; positive regulation of cell death [GO:0010942]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:15496587}; IsoId=Q9UHR5-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:14702039}; IsoId=Q9UHR5-2; Sequence=VSP_052091; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q96RN1
geneSymbol: SLC26A8
name: Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8)
length: 970
go: ENSG00000112053;
snps: rs743923 rs140210148 rs17713154 rs17707331 rs2295852 rs142724470 rs398123027
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; anion transport [GO:0006820]; chloride transport [GO:0006821]; flagellated sperm motility [GO:0030317]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]; sulfate transport [GO:0008272]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:11834742, ECO:0000269|Ref.3}; IsoId=Q96RN1-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=Q96RN1-2; Sequence=VSP_052705; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000269|PubMed:14574404}; IsoId=Q96RN1-3; Sequence=VSP_052704, VSP_052706; Note=No experimental confirmation available. {ECO:0000305}; Name=4 {ECO:0000269|PubMed:14702039}; IsoId=Q96RN1-4; Sequence=VSP_052707, VSP_052708; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:17517695}; Multi-pass membrane protein {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:17517695}. Note=Located at the annulus ring structure within the sperm cell. {ECO:0000269|PubMed:11278976, ECO:0000269|PubMed:17517695}.


uniprotID: Q86WA9
geneSymbol: SLC26A11
reactome: R-HSA-427601;
name: Sodium-independent sulfate anion transporter (Solute carrier family 26 member 11)
length: 606
go: ENSG00000181045;
snps: rs765188926
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; anion transmembrane transporter activity [GO:0008509]; anion:anion antiporter activity [GO:0015301]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; ion transport [GO:0006811]; sulfate transport [GO:0008272]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12626430}; Multi-pass membrane protein {ECO:0000269|PubMed:12626430}. Lysosome membrane; Multi-pass membrane protein {ECO:0000269|PubMed:12626430}.


uniprotID: Q7LBE3
geneSymbol: SLC26A9
reactome: R-HSA-427601;
name: Solute carrier family 26 member 9 (Anion transporter/exchanger protein 9)
length: 791
go: ENSG00000174502;
snps: rs75021701 rs77497889 rs112659452 rs201823199 rs74146719 rs34992672 rs3811428 rs16856462
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; ATPase binding [GO:0051117]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride channel activity [GO:0005254]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; anion transport [GO:0006820]; bicarbonate transport [GO:0015701]; chloride transport [GO:0006821]; ion transport [GO:0006811]; positive regulation of gene expression [GO:0010628]; regulation of membrane potential [GO:0042391]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7LBE3-1; Sequence=Displayed; Name=2; IsoId=Q7LBE3-2; Sequence=VSP_054056; 


uniprotID: Q6ZUB1
geneSymbol: SPATA31E1
name: Spermatogenesis-associated protein 31E1 (Protein FAM75E1)
length: 1445
go: ENSG00000177992;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

snps:
rs28510722 rs7850542 rs34946554 rs35232271 rs36079890 rs4076795 rs34017995 rs4076794 rs34791830 rs34051334 rs10868670 rs11789780 rs11142017 


uniprotID: P0CK96
geneSymbol: SLC35E2B
name: Solute carrier family 35 member E2B
length: 405
go: ENSG00000189339;
opentargets: integral component of membrane [GO:0016021]; blastocyst hatching [GO:0001835]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: P78382
geneSymbol: SLC35A1
reactome: R-HSA-4085001;R-HSA-5619037;R-HSA-5663020;R-HSA-727802;
name: CMP-sialic acid transporter (CMP-SA-Tr) (CMP-Sia-Tr) (Solute carrier family 35 member A1)
length: 337
go: ENSG00000164414;
location: SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of Golgi membrane [GO:0030173]; integral component of plasma membrane [GO:0005887]; CMP-N-acetylneuraminate transmembrane transporter activity [GO:0005456]; sialic acid transmembrane transporter activity [GO:0015136]; carbohydrate metabolic process [GO:0005975]; carbohydrate transport [GO:0008643]; cellular protein modification process [GO:0006464]; CMP-N-acetylneuraminate transmembrane transport [GO:0015782]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P78382-1; Sequence=Displayed; Name=2; IsoId=P78382-2; Sequence=VSP_042916; Note=No experimental confirmation available.; 


uniprotID: Q6P1M0
geneSymbol: SLC27A4
reactome: R-HSA-5619108;R-HSA-804914;
length: 643
go: ENSG00000167114;
snps: rs137853132 rs2240953 rs137853133 rs137853134 rs768495407 rs137853135
name:
Long-chain fatty acid transport protein 4 (FATP-4) (Fatty acid transport protein 4) (EC 6.2.1.-) (Solute carrier family 27 member 4)

sequence:

opentargets:
brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; fatty acid transport [GO:0015908]; lipid metabolic process [GO:0006629]; long-chain fatty acid import [GO:0044539]; long-chain fatty acid metabolic process [GO:0001676]; long-chain fatty acid transport [GO:0015909]; medium-chain fatty acid transport [GO:0001579]; response to nutrient [GO:0007584]; skin development [GO:0043588]; very long-chain fatty acid catabolic process [GO:0042760]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P1M0-1; Sequence=Displayed; Name=2; IsoId=Q6P1M0-2; Sequence=VSP_055808, VSP_055809; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}.


uniprotID: Q8TB61
geneSymbol: SLC35B2
reactome: R-HSA-174362;R-HSA-727802;
length: 432
go: ENSG00000157593;
snps: rs3734707
name:
Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (PAPS transporter 1) (Putative MAPK-activating protein PM15) (Putative NF-kappa-B-activating protein 48) (Solute carrier family 35 member B2)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of Golgi membrane [GO:0030173]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; 3'-phosphoadenosine 5'-phosphosulfate transport [GO:0046963]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8TB61-1; Sequence=Displayed; Name=2; IsoId=Q8TB61-2; Sequence=VSP_014084; Name=3; IsoId=Q8TB61-3; Sequence=VSP_026949; Note=No experimental confirmation available.; Name=4; IsoId=Q8TB61-4; Sequence=VSP_054696, VSP_054697; Note=No experimental confirmation available.; Name=5; IsoId=Q8TB61-5; Sequence=VSP_057436; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12716889}; Multi-pass membrane protein {ECO:0000269|PubMed:12716889}.


uniprotID: Q9Y2P4
geneSymbol: SLC27A6
reactome: R-HSA-804914;
length: 619
go: ENSG00000113396;
snps: rs2526247
name:
Long-chain fatty acid transport protein 6 (FATP-6) (Fatty acid transport protein 6) (Fatty-acid-coenzyme A ligase, very long-chain 2) (Solute carrier family 27 member 6) (Very long-chain acyl-CoA synthetase homolog 1) (VLCSH1) (hVLCS-H1)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; fatty acid transmembrane transporter activity [GO:0015245]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; very long-chain fatty acid-CoA ligase activity [GO:0031957]; long-chain fatty acid transport [GO:0015909]; very long-chain fatty acid metabolic process [GO:0000038]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250}. Note=In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36. {ECO:0000250}.


uniprotID: Q8N357
geneSymbol: SLC35F6
length: 371
go: ENSG00000213699;
location: SUBCELLULAR LOCATION: Mitochondrion. Lysosome membrane; Multi-pass membrane protein.
name:
Solute carrier family 35 member F6 (ANT2-binding protein) (ANT2BP) (Transport and Golgi organization 9 homolog)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; transmembrane transporter activity [GO:0022857]; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901029]; positive regulation of cell proliferation [GO:0008284]


uniprotID: Q969S0
geneSymbol: SLC35B4
reactome: R-HSA-727802;
length: 331
go: ENSG00000205060;
name:
UDP-xylose and UDP-N-acetylglucosamine transporter (Solute carrier family 35 member B4) (YEA4 homolog)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of Golgi membrane [GO:0030173]; 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [GO:0046964]; GDP-fucose transmembrane transporter activity [GO:0005457]; UDP-N-acetylglucosamine transmembrane transporter activity [GO:0005462]; UDP-xylose transmembrane transporter activity [GO:0005464]; carbohydrate transport [GO:0008643]; GDP-fucose transmembrane transport [GO:0015783]; regulation of gluconeogenesis [GO:0006111]; UDP-N-acetylglucosamine transmembrane transport [GO:1990569]; UDP-xylose transmembrane transport [GO:0015790]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q969S0-1; Sequence=Displayed; Name=2; IsoId=Q969S0-2; Sequence=VSP_016197, VSP_016198; Name=3; IsoId=Q969S0-3; Sequence=VSP_016199, VSP_016200; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15911612}; Multi-pass membrane protein {ECO:0000269|PubMed:15911612}.


uniprotID: Q9NQQ7
geneSymbol: SLC35C2
name: Solute carrier family 35 member C2 (Ovarian cancer-overexpressed gene 1 protein)
length: 365
go: ENSG00000080189;
sequence:

opentargets:
cis-Golgi network [GO:0005801]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; negative regulation of gene expression [GO:0010629]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked fucosylation [GO:0036066]; UDP-glucose transmembrane transport [GO:0015786]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NQQ7-1; Sequence=Displayed; Name=2; IsoId=Q9NQQ7-2; Sequence=VSP_009229; Name=3; IsoId=Q9NQQ7-3; Sequence=VSP_056729; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:20837470}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:20837470}.


uniprotID: P0C7Q6
geneSymbol: SLC35G6
length: 338
opentargets: integral component of membrane [GO:0016021]
snps: rs3760422 rs4491591 rs7209977
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Solute carrier family 35 member G6 (Acyl-malonyl-condensing enzyme 1-like protein 3) (Transmembrane protein 21B)

sequence:


uniprotID: Q76EJ3
geneSymbol: SLC35D2
reactome: R-HSA-2022854;R-HSA-2022928;R-HSA-727802;
length: 337
go: ENSG00000130958;
snps: rs1051763
name:
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (Homolog of Fringe connection protein 1) (HFRC1) (SQV7-like protein) (SQV7L) (Solute carrier family 35 member D2) (UDP-galactose transporter-related protein 8) (UGTrel8)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; nucleotide-sugar transmembrane transporter activity [GO:0005338]; pyrimidine nucleotide-sugar transmembrane transporter activity [GO:0015165]; carbohydrate transport [GO:0008643]; glycosaminoglycan biosynthetic process [GO:0006024]; keratan sulfate biosynthetic process [GO:0018146]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q76EJ3-1; Sequence=Displayed; Name=2; IsoId=Q76EJ3-2; Sequence=VSP_030006; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}; Multi-pass membrane protein {ECO:0000269|PubMed:15082721, ECO:0000269|PubMed:15607426}.


uniprotID: Q7RTT9
geneSymbol: SLC29A4
reactome: R-HSA-83936;
length: 530
go: ENSG00000164638;
drug: DB00331;
snps: rs17854505 rs17855675 rs17857336
name:
Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (Solute carrier family 29 member 4)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; monoamine transmembrane transporter activity [GO:0008504]; nucleoside transmembrane transporter activity [GO:0005337]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7RTT9-1; Sequence=Displayed; Name=2; IsoId=Q7RTT9-2; Sequence=VSP_032647; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells. {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718}.


uniprotID: Q9H2H9
geneSymbol: SLC38A1
reactome: R-HSA-210455;R-HSA-352230;
length: 487
go: ENSG00000111371;
name:
Sodium-coupled neutral amino acid transporter 1 (Amino acid transporter A1) (N-system amino acid transporter 2) (Solute carrier family 38 member 1) (System A amino acid transporter 1) (System N amino acid transporter 1)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid:sodium symporter activity [GO:0005283]; L-amino acid transmembrane transporter activity [GO:0015179]; neutral amino acid transmembrane transporter activity [GO:0015175]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; neurotransmitter uptake [GO:0001504]; neutral amino acid transport [GO:0015804]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000269|PubMed:15054072}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity). {ECO:0000250}.


uniprotID: A6NNN8
geneSymbol: SLC38A8
name: Putative sodium-coupled neutral amino acid transporter 8 (Solute carrier family 38 member 8)
length: 435
go: ENSG00000166558;
snps: rs587777253 rs11862366 rs372929441 rs587777254 rs587777256
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]


uniprotID: Q9ULF5
geneSymbol: SLC39A10
reactome: R-HSA-442380;
name: Zinc transporter ZIP10 (Solute carrier family 39 member 10) (Zrt- and Irt-like protein 10) (ZIP-10)
length: 831
go: ENSG00000196950;
snps: rs13419724
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; negative regulation of B cell apoptotic process [GO:0002903]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of protein tyrosine phosphatase activity [GO:1903615]; zinc ion import across plasma membrane [GO:0071578]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULF5-1; Sequence=Displayed; Name=2; IsoId=Q9ULF5-2; Sequence=VSP_055991; Note=No experimental confirmation available.; 


uniprotID: Q504Y0
geneSymbol: SLC39A12
length: 691
go: ENSG00000148482;
snps: rs10764176 rs7899328 rs2478568 rs11011935
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Zinc transporter ZIP12 (LIV-1 subfamily of ZIP zinc transporter 8) (LZT-Hs8) (Solute carrier family 39 member 12) (Zrt- and Irt-like protein 12) (ZIP-12)

sequence:

opentargets:
extracellular vesicle [GO:1903561]; integral component of plasma membrane [GO:0005887]; perinuclear region of cytoplasm [GO:0048471]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; regulation of microtubule polymerization [GO:0031113]; regulation of neuron projection development [GO:0010975]; signal transduction [GO:0007165]; zinc ion import across plasma membrane [GO:0071578]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q504Y0-1; Sequence=Displayed; Name=2; IsoId=Q504Y0-2; Sequence=VSP_029847, VSP_029848; Note=No experimental confirmation available.; Name=3; IsoId=Q504Y0-3; Sequence=VSP_029849; Note=No experimental confirmation available.; Name=4; IsoId=Q504Y0-4; Sequence=VSP_029850; Note=No experimental confirmation available.; Name=5; IsoId=Q504Y0-5; Sequence=VSP_057594; 


uniprotID: Q6ZMH5
geneSymbol: SLC39A5
reactome: R-HSA-442380;
name: Zinc transporter ZIP5 (Solute carrier family 39 member 5) (Zrt- and Irt-like protein 5) (ZIP-5)
length: 540
go: ENSG00000139540;
snps: rs587777625
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; zinc ion transmembrane transporter activity [GO:0005385]; BMP signaling pathway [GO:0030509]; cellular response to zinc ion starvation [GO:0034224]; cellular zinc ion homeostasis [GO:0006882]; eye development [GO:0001654]; G1 to G0 transition involved in cell differentiation [GO:0070315]; neural precursor cell proliferation [GO:0061351]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; zinc ion import across plasma membrane [GO:0071578]

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q13433
geneSymbol: SLC39A6
reactome: R-HSA-442380;
length: 755
go: ENSG00000141424;
snps: rs1789528
name:
Zinc transporter ZIP6 (Estrogen-regulated protein LIV-1) (Solute carrier family 39 member 6) (Zrt- and Irt-like protein 6) (ZIP-6)

sequence:

opentargets:
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; integral component of plasma membrane [GO:0005887]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13433-1; Sequence=Displayed; Name=2; IsoId=Q13433-2; Sequence=VSP_014309, VSP_014310, VSP_014311; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12839489}; Multi-pass membrane protein {ECO:0000269|PubMed:12839489}.


uniprotID: Q5T1Q4
geneSymbol: SLC35F1
name: Solute carrier family 35 member F1
length: 408
go: ENSG00000196376;
opentargets: integral component of membrane [GO:0016021]; transmembrane transporter activity [GO:0022857]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T1Q4-1; Sequence=Displayed; Name=2; IsoId=Q5T1Q4-2; Sequence=VSP_057263; Note=No experimental confirmation available.; 


uniprotID: Q8TE82
geneSymbol: SH3TC1
name: SH3 domain and tetratricopeptide repeat-containing protein 1
length: 1336
go: ENSG00000125089;
snps: rs1281138 rs1281145 rs201295499 rs1281149
sequence:


uniprotID: Q8TF17
geneSymbol: SH3TC2
name: SH3 domain and tetratricopeptide repeat-containing protein 2
length: 1288
go: ENSG00000169247;
snps: rs80359890 rs17722293 rs6875902 rs863224454 rs80338925 rs80338926 rs17109261
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; plasma membrane [GO:0005886]; peripheral nervous system myelin maintenance [GO:0032287]; regulation of ERBB signaling pathway [GO:1901184]; regulation of intracellular protein transport [GO:0033157]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8TF17-1; Sequence=Displayed; Name=2; IsoId=Q8TF17-2; Sequence=VSP_009884, VSP_009885; Note=No experimental confirmation available.; Name=3; IsoId=Q8TF17-3; Sequence=VSP_009884, VSP_009885, VSP_009886; Note=No experimental confirmation available.; Name=4; IsoId=Q8TF17-4; Sequence=VSP_009881, VSP_009882, VSP_009883; Note=No experimental confirmation available.; Name=5; IsoId=Q8TF17-5; Sequence=VSP_054499; Note=No experimental confirmation available.; 


uniprotID: Q9UMX9
geneSymbol: SLC45A2
reactome: R-HSA-5662702;
length: 530
go: ENSG00000164175;
name:
Membrane-associated transporter protein (Melanoma antigen AIM1) (Protein AIM-1) (Solute carrier family 45 member 2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; melanosome membrane [GO:0033162]; sucrose:proton symporter activity [GO:0008506]; developmental pigmentation [GO:0048066]; melanin biosynthetic process [GO:0042438]; response to stimulus [GO:0050896]; sucrose transport [GO:0015770]; visual perception [GO:0007601]

snps:
rs1290584600 rs925113610 rs762813061 rs121912621 rs146802593 rs26722 rs553073635 rs372465070 rs146930801 rs121912619 rs1307137184 rs16891982 rs144503724 rs121912620 rs11568737 rs3733808 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=AIM-1a; IsoId=Q9UMX9-1; Sequence=Displayed; Name=2; Synonyms=AIM-1b; IsoId=Q9UMX9-2; Sequence=VSP_006297, VSP_006298, VSP_006299; Name=3; Synonyms=AIM-1c; IsoId=Q9UMX9-3; Sequence=VSP_006296; Note=No experimental confirmation available.; Name=4; IsoId=Q9UMX9-4; Sequence=VSP_041220, VSP_041221; 

location:
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:17081065}; Multi-pass membrane protein {ECO:0000269|PubMed:17081065}.


uniprotID: Q8NBS3
geneSymbol: SLC4A11
length: 891
go: ENSG00000088836;
name:
Sodium bicarbonate transporter-like protein 11 (Bicarbonate transporter-related protein 1) (Sodium borate cotransporter 1) (NaBC1) (Solute carrier family 4 member 11)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of plasma membrane [GO:0005887]; active borate transmembrane transporter activity [GO:0046715]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; inorganic anion exchanger activity [GO:0005452]; protein dimerization activity [GO:0046983]; proton channel activity [GO:0015252]; sodium channel activity [GO:0005272]; symporter activity [GO:0015293]; bicarbonate transport [GO:0015701]; borate transport [GO:0046713]; cellular cation homeostasis [GO:0030003]; fluid transport [GO:0042044]; proton transmembrane transport [GO:1902600]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814]

snps:
rs778688114 rs200940928 rs34520315 rs752287261 rs141836046 rs566507872 rs759667344 rs121909395 rs762942751 rs760889152 rs780171125 rs267607065 rs121909389 rs121909393 rs121909388 rs532728316 rs150571742 rs755379986 rs754745672 rs144734280 rs139078082 rs749826950 rs267607064 rs143965185 rs267607066 rs121909387 rs757553189 rs766567944 rs757244518 rs144586846 rs121909394 rs34224785 rs121909396 rs121909391 rs121909392 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8NBS3-1; Sequence=Displayed; Name=2; IsoId=Q8NBS3-2; Sequence=VSP_035891; Note=No experimental confirmation available.; Name=3; IsoId=Q8NBS3-3; Sequence=VSP_044846; Note=No experimental confirmation available.; Name=4; IsoId=Q8NBS3-4; Sequence=VSP_054049; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18024964, ECO:0000269|PubMed:25007886}. Membrane {ECO:0000269|PubMed:18024964}; Multi-pass membrane protein {ECO:0000269|PubMed:18024964}.


uniprotID: Q7Z3Q1
geneSymbol: SLC46A3
name: Solute carrier family 46 member 3
length: 461
go: ENSG00000139508;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z3Q1-1; Sequence=Displayed; Name=2; IsoId=Q7Z3Q1-2; Sequence=VSP_028649; Name=3; IsoId=Q7Z3Q1-3; Sequence=VSP_028648; Note=No experimental confirmation available.; 


uniprotID: P48066
geneSymbol: SLC6A11
reactome: R-HSA-442660;R-HSA-71288;R-HSA-888593;
name: Sodium- and chloride-dependent GABA transporter 3 (GAT-3) (Solute carrier family 6 member 11)
length: 632
go: ENSG00000132164;
drug: DB00349;DB08848;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
cytoplasm [GO:0005737]; GABA-ergic synapse [GO:0098982]; integral component of membrane [GO:0016021]; integral component of postsynaptic membrane [GO:0099055]; integral component of presynaptic membrane [GO:0099056]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; gamma-aminobutyric acid:sodium symporter activity [GO:0005332]; neurotransmitter binding [GO:0042165]; brain development [GO:0007420]; response to drug [GO:0042493]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48066-1; Sequence=Displayed; Name=2; IsoId=P48066-2; Sequence=VSP_056539; Note=No experimental confirmation available.; 


uniprotID: P48065
geneSymbol: SLC6A12
reactome: R-HSA-352230;R-HSA-442660;R-HSA-71288;R-HSA-888593;
length: 614
go: ENSG00000111181;
drug: DB08848;
snps: rs557881
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Sodium- and chloride-dependent betaine transporter (BGT-1) (Na(+)/Cl(-) betaine/GABA transporter) (Solute carrier family 6 member 12)

sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:sodium symporter activity [GO:0005332]; neurotransmitter binding [GO:0042165]; amino acid transport [GO:0006865]


uniprotID: Q9NWF4
geneSymbol: SLC52A1
reactome: R-HSA-196843;
length: 448
go: ENSG00000132517;
snps: rs346822 rs346821 rs2304445 rs187609896
name:
Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; riboflavin transmembrane transporter activity [GO:0032217]; virus receptor activity [GO:0001618]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NWF4-1; Sequence=Displayed; Name=2; Synonyms=RFT1sv; IsoId=Q9NWF4-2; Sequence=VSP_039888, VSP_039889; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}; Multi-pass membrane protein {ECO:0000269|PubMed:18632736, ECO:0000269|PubMed:20463145}.


uniprotID: Q9NQ40
geneSymbol: SLC52A3
reactome: R-HSA-196843;
name: Solute carrier family 52, riboflavin transporter, member 3 (Riboflavin transporter 2) (hRFT2)
length: 469
go: ENSG00000101276;
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; riboflavin transmembrane transporter activity [GO:0032217]; cellular response to heat [GO:0034605]; riboflavin metabolic process [GO:0006771]; riboflavin transport [GO:0032218]; sensory perception of sound [GO:0007605]

snps:
rs797045190 rs199588390 rs267606688 rs267606686 rs797045192 rs267606683 rs35655964 rs267606684 rs6054614 rs797045194 rs267606685 rs370499474 rs3746804 rs3746803 rs3746802 rs752218005 rs797045195 rs797045196 rs76947760 rs1219868273 rs910857 rs267606687 rs779750163 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=SLC52A3a {ECO:0000303|PubMed:29428966}; IsoId=Q9NQ40-1; Sequence=Displayed; Name=2; Synonyms=SLC52A3b {ECO:0000303|PubMed:29428966}; IsoId=Q9NQ40-2; Sequence=VSP_003814, VSP_003815; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:20463145, ECO:0000269|PubMed:21512156, ECO:0000269|PubMed:24264046}; Multi-pass membrane protein {ECO:0000269|PubMed:20463145}. Cell membrane {ECO:0000269|PubMed:22273710, ECO:0000269|PubMed:27702554}.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:29428966}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000269|PubMed:29428966}; Multi-pass membrane protein. Cytoplasm {ECO:0000269|PubMed:29428966}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:29428966}.


uniprotID: Q96N87
geneSymbol: SLC6A18
reactome: R-HSA-352230;R-HSA-442660;R-HSA-5619079;R-HSA-5659729;
length: 628
go: ENSG00000164363;
snps: rs34469326 rs7728667 rs7705355 rs113861454 rs4073918 rs147278493
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Sodium-dependent neutral amino acid transporter B(0)AT3 (Sodium- and chloride-dependent transporter XTRP2) (Solute carrier family 6 member 18) (System B(0) neutral amino acid transporter AT3)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; neurotransmitter:sodium symporter activity [GO:0005328]; neutral amino acid transmembrane transporter activity [GO:0015175]; amino acid transport [GO:0006865]


uniprotID: P18405
geneSymbol: SRD5A1
reactome: R-HSA-193048;
length: 259
go: ENSG00000145545;
drug: DB01126;DB01216;DB00367;DB09389;DB06412;DB00421;
name:
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (EC 1.3.1.22) (SR type 1) (Steroid 5-alpha-reductase 1) (S5AR 1)

sequence:

opentargets:
cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; perinuclear region of cytoplasm [GO:0048471]; 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; amide binding [GO:0033218]; cholestenone 5-alpha-reductase activity [GO:0047751]; electron transfer activity [GO:0009055]; NADPH binding [GO:0070402]; oxidoreductase activity [GO:0016491]; androgen biosynthetic process [GO:0006702]; androgen catabolic process [GO:0006710]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to estradiol stimulus [GO:0071392]; cellular response to growth factor stimulus [GO:0071363]; cellular response to insulin stimulus [GO:0032869]; cellular response to starvation [GO:0009267]; cellular response to testosterone stimulus [GO:0071394]; cerebral cortex development [GO:0021987]; circadian sleep/wake cycle, REM sleep [GO:0042747]; diterpenoid metabolic process [GO:0016101]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; liver development [GO:0001889]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; pituitary gland development [GO:0021983]; progesterone metabolic process [GO:0042448]; response to estrogen [GO:0043627]; response to follicle-stimulating hormone [GO:0032354]; response to fungicide [GO:0060992]; response to growth hormone [GO:0060416]; response to muscle activity [GO:0014850]; serotonin metabolic process [GO:0042428]; sex determination [GO:0007530]; spinal cord development [GO:0021510]; steroid biosynthetic process [GO:0006694]; thalamus development [GO:0021794]; urogenital system development [GO:0001655]

location:
SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q9NP91
geneSymbol: SLC6A20
reactome: R-HSA-352230;R-HSA-442660;R-HSA-5619101;R-HSA-5660686;
length: 592
go: ENSG00000163817;
snps: rs2271615 rs17279437
name:
Sodium- and chloride-dependent transporter XTRP3 (Sodium/imino-acid transporter 1) (Solute carrier family 6 member 20) (Transporter rB21A homolog)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; L-proline transmembrane transporter activity [GO:0015193]; neurotransmitter:sodium symporter activity [GO:0005328]; amino acid transport [GO:0006865]; glycine transport [GO:0015816]; proline transport [GO:0015824]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=XT3; IsoId=Q9NP91-1; Sequence=Displayed; Name=2; Synonyms=XT3a; IsoId=Q9NP91-2; Sequence=VSP_050002; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Located in the apical brush border membrane of kidney proximal tubule cells. {ECO:0000250}.


uniprotID: P31213
geneSymbol: SRD5A2
reactome: R-HSA-193048;
length: 254
drug: DB00548;DB01126;DB01216;DB00421;
snps: rs9282858 rs523349 rs28383048 rs9332961 rs9332963 rs9332963 rs9332964 rs9332967
name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (EC 1.3.1.22) (5 alpha-SR2) (SR type 2) (Steroid 5-alpha-reductase 2) (S5AR 2) (Type II 5-alpha reductase)

sequence:

opentargets:
cell body fiber [GO:0070852]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; organelle membrane [GO:0031090]; 3-oxo-5-alpha-steroid 4-dehydrogenase activity [GO:0003865]; amide binding [GO:0033218]; cholestenone 5-alpha-reductase activity [GO:0047751]; oxidoreductase activity [GO:0016491]; sterol 5-alpha reductase activity [GO:0009917]; testosterone dehydrogenase [NAD(P)] activity [GO:0030283]; androgen biosynthetic process [GO:0006702]; androgen metabolic process [GO:0008209]; biphenyl metabolic process [GO:0018879]; bone development [GO:0060348]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; dibenzo-p-dioxin metabolic process [GO:0018894]; female genitalia development [GO:0030540]; hippocampus development [GO:0021766]; hypothalamus development [GO:0021854]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; phthalate metabolic process [GO:0018963]; response to drug [GO:0042493]; response to follicle-stimulating hormone [GO:0032354]; response to nutrient levels [GO:0031667]; response to peptide hormone [GO:0043434]; response to steroid hormone [GO:0048545]; response to testosterone [GO:0033574]; steroid catabolic process [GO:0006706]; testosterone biosynthetic process [GO:0061370]

location:
SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q8TCU3
geneSymbol: SLC7A13
length: 470
go: ENSG00000164893;
snps: rs2976189 rs4419794 rs9656982 rs9693999
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Solute carrier family 7 member 13 (Sodium-independent aspartate/glutamate transporter 1) (X-amino acid transporter 2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; L-amino acid transmembrane transporter activity [GO:0015179]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TCU3-1; Sequence=Displayed; Name=2; IsoId=Q8TCU3-2; Sequence=VSP_033067, VSP_033068, VSP_033069; 


uniprotID: P61619
geneSymbol: SEC61A1
reactome: R-HSA-1236974;R-HSA-1799339;R-HSA-381038;
name: Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1)
length: 476
go: ENSG00000058262;
snps: rs752745051 rs879255648
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; membrane [GO:0016020]; Sec61 translocon complex [GO:0005784]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]; cotranslational protein targeting to membrane [GO:0006613]; endoplasmic reticulum organization [GO:0007029]; posttranslational protein targeting to endoplasmic reticulum membrane [GO:0006620]; pronephric nephron development [GO:0039019]; protein targeting to ER [GO:0045047]; response to interferon-gamma [GO:0034341]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61619-1; Sequence=Displayed; Name=3; IsoId=P61619-3; Sequence=VSP_013747; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27392076}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). {ECO:0000269|PubMed:27392076}.


uniprotID: Q96CW6
geneSymbol: SLC7A6OS
length: 309
go: ENSG00000103061;
snps: rs35800405 rs3803650 rs8063446 rs11548855
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
name:
Probable RNA polymerase II nuclear localization protein SLC7A6OS (ADAMS proteinase-related protein) (Solute carrier family 7 member 6 opposite strand transcript)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; developmental process [GO:0032502]; hematopoietic progenitor cell differentiation [GO:0002244]; protein transport [GO:0015031]


uniprotID: P35542
geneSymbol: SAA4
name: Serum amyloid A-4 protein (Constitutively expressed serum amyloid A protein) (C-SAA)
length: 130
go: ENSG00000148965;
snps: rs2460827
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MRLFTGIVFCSLVMGVTSESWRSFFKEALQGVGDMGRAYWDIMISNHQNSNRYLYARGNYDAAQRGPGGVWAAKLISRSRVYLQGLIDCYLFGNSSTVLEDSKSNEKAEEWGRSGKDPDRFRPDGLPKKY

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; chemoattractant activity [GO:0042056]; acute-phase response [GO:0006953]; cell chemotaxis [GO:0060326]


uniprotID: Q96ER3
geneSymbol: SAAL1
length: 474
go: ENSG00000166788;
opentargets: extracellular space [GO:0005615]; nucleus [GO:0005634]
snps: rs35525096 rs28930681
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22127701}.
name:
Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1)

sequence:


uniprotID: Q14151
geneSymbol: SAFB2
name: Scaffold attachment factor B2 (SAF-B2)
length: 953
go: ENSG00000130254;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of mRNA processing [GO:0050684]; regulation of transcription by RNA polymerase II [GO:0006357]; Sertoli cell differentiation [GO:0060008]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14151-1; Sequence=Displayed; Name=2; IsoId=Q14151-2; Sequence=VSP_056404, VSP_056405; Note=No experimental confirmation available.; 


uniprotID: Q9Y467
geneSymbol: SALL2
length: 1007
snps: rs2242527 rs1263811 rs1263810
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Sal-like protein 2 (Zinc finger protein 795) (Zinc finger protein SALL2) (Zinc finger protein Spalt-2) (Sal-2) (hSal2)

sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; eye development [GO:0001654]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y467-1; Sequence=Displayed; Name=2; IsoId=Q9Y467-3; Sequence=VSP_056251, VSP_056252, VSP_056253; Note=No experimental confirmation available.; 


uniprotID: Q9UJQ4
geneSymbol: SALL4
reactome: R-HSA-2892247;R-HSA-452723;R-HSA-8943724;
name: Sal-like protein 4 (Zinc finger protein 797) (Zinc finger protein SALL4)
length: 1053
go: ENSG00000101115;
snps: rs6126344 rs6091375 rs74315429
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
sequence:

opentargets:
cytoplasm [GO:0005737]; heterochromatin [GO:0000792]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription factor binding [GO:0008134]; embryonic limb morphogenesis [GO:0030326]; inner cell mass cell proliferation [GO:0001833]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]; somatic stem cell population maintenance [GO:0035019]; ventricular septum development [GO:0003281]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=SALL4A; IsoId=Q9UJQ4-1; Sequence=Displayed; Name=SALL4B; IsoId=Q9UJQ4-2; Sequence=VSP_046525; 


uniprotID: Q9BYL1
geneSymbol: SAMD10
name: Sterile alpha motif domain-containing protein 10 (SAM domain-containing protein 10)
length: 202
go: ENSG00000130590;
sequence:


uniprotID: Q70HW3
geneSymbol: SLC25A26
reactome: R-HSA-425393;
length: 274
go: ENSG00000144741;
snps: rs146159281 rs869025314 rs869025313 rs869025315 rs13874
name:
S-adenosylmethionine mitochondrial carrier protein (Mitochondrial S-adenosylmethionine transporter) (Solute carrier family 25 member 26)

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; S-adenosyl-L-methionine transmembrane transporter activity [GO:0000095]; ion transport [GO:0006811]; S-adenosyl-L-methionine transport [GO:0015805]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q70HW3-1; Sequence=Displayed; Name=2; IsoId=Q70HW3-2; Sequence=VSP_031062; Name=3; IsoId=Q70HW3-3; Sequence=VSP_031062, VSP_031063, VSP_031064; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:14674884}; Multi-pass membrane protein {ECO:0000269|PubMed:14674884}.


uniprotID: Q5VXD3
geneSymbol: SAMD13
name: Sterile alpha motif domain-containing protein 13 (SAM domain-containing protein 13)
length: 122
go: ENSG00000203943;
sequence:
MANSLLEGVFAEVKEPCSLPMLSVDMENKENGSVGVKNSMENGRPPDPADWAVMDVVNYFRTVGFEEQASAFQEQEIDGKSLLLMTRNDVLTGLQLKLGPALKIYEYHVKPLQTKHLKNNSS

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5VXD3-1; Sequence=Displayed; Name=2; IsoId=Q5VXD3-2; Sequence=VSP_023463; Note=No experimental confirmation available.; Name=3; IsoId=Q5VXD3-3; Sequence=VSP_023464; Note=No experimental confirmation available.; Name=4; IsoId=Q5VXD3-4; Sequence=VSP_044972; Note=No experimental confirmation available.; 


uniprotID: O75446
geneSymbol: SAP30
reactome: R-HSA-3214815;R-HSA-427413;
pdb: 2KDP;
length: 220
go: ENSG00000164105;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Histone deacetylase complex subunit SAP30 (30 kDa Sin3-associated polypeptide) (Sin3 corepressor complex subunit SAP30) (Sin3-associated polypeptide p30)

sequence:

opentargets:
histone deacetylase complex [GO:0000118]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; histone deacetylase activity [GO:0004407]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of transcription, DNA-templated [GO:0006355]; skeletal muscle cell differentiation [GO:0035914]


uniprotID: Q9Y6B6
geneSymbol: SAR1B
reactome: R-HSA-1655829;R-HSA-204005;R-HSA-2132295;R-HSA-5694530;R-HSA-8963888;R-HSA-983170;
name: GTP-binding protein SAR1b (GTP-binding protein B) (GTBPB)
length: 198
go: ENSG00000152700;
drug: DB04315;
snps: rs121917846 rs1254114609 rs28942109 rs28942110
sequence:
MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPTSEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMTDETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSVLKRQGYGEGFRWMAQYID

opentargets:
COPII vesicle coat [GO:0030127]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi cisterna membrane [GO:0032580]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; regulation of COPII vesicle coating [GO:0003400]; vesicle organization [GO:0016050]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus, Golgi stack membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region. {ECO:0000250}.


uniprotID: P82979
geneSymbol: SARNP
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72187;
pdb: 2DO1;
length: 210
go: ENSG00000205323;
location: SUBCELLULAR LOCATION: Nucleus. Nucleus speckle.
name:
SAP domain-containing ribonucleoprotein (Cytokine-induced protein of 29 kDa) (Nuclear protein Hcc-1) (Proliferation-associated cytokine-inducible protein CIP29)

sequence:

opentargets:
cytoplasmic ribonucleoprotein granule [GO:0036464]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription export complex [GO:0000346]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; regulation of translation [GO:0006417]; RNA export from nucleus [GO:0006405]


uniprotID: Q6UVJ0
geneSymbol: SASS6
name: Spindle assembly abnormal protein 6 homolog (HsSAS-6)
length: 657
go: ENSG00000156876;
snps: rs876661307 rs13375867
sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; deuterosome [GO:0098536]; microtubule organizing center [GO:0005815]; centriole replication [GO:0007099]; centrosome duplication [GO:0051298]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:24107630}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15572125, ECO:0000269|PubMed:15665853, ECO:0000269|PubMed:17681131}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (By similarity). Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis. {ECO:0000250|UniProtKB:Q80UK7}.


uniprotID: Q15020
geneSymbol: SART3
pdb: 2DO4;5CTQ;5CTR;5CTT;5JJW;5JJX;5JPZ;
length: 963
go: ENSG00000075856;
snps: rs2072579 rs118203954 rs2287546
name:
Squamous cell carcinoma antigen recognized by T-cells 3 (SART-3) (Tat-interacting protein of 110 kDa) (Tip110) (p110 nuclear RNA-binding protein)

sequence:

opentargets:
ASAP complex [GO:0061574]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone binding [GO:0042393]; RNA binding [GO:0003723]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; U6atac snRNA binding [GO:0030624]; ubiquitin-specific protease binding [GO:1990381]; cell morphogenesis [GO:0000902]; hematopoietic stem cell proliferation [GO:0071425]; homeostasis of number of cells [GO:0048872]; mRNA splicing, via spliceosome [GO:0000398]; nucleosome assembly [GO:0006334]; positive regulation of histone deubiquitination [GO:1903586]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of gene expression [GO:0010468]; RNA splicing [GO:0008380]; spliceosomal snRNP assembly [GO:0000387]; spliceosomal tri-snRNP complex assembly [GO:0000244]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q15020-1; Sequence=Displayed; Name=2; IsoId=Q15020-2; Sequence=VSP_017250, VSP_017251; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Inactive in U4/U6 snRNP recycling. {ECO:0000269|PubMed:15314151}; Name=3; IsoId=Q15020-3; Sequence=VSP_017248, VSP_017249; Note=No experimental confirmation available.; Name=4; IsoId=Q15020-4; Sequence=VSP_057284; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:10463607, ECO:0000269|PubMed:11959860, ECO:0000269|PubMed:12578909}. Nucleus, Cajal body {ECO:0000269|PubMed:12578909}. Nucleus speckle {ECO:0000269|PubMed:11959860}. Cytoplasm {ECO:0000269|PubMed:10463607, ECO:0000269|PubMed:11959860}.


uniprotID: Q9NX95
geneSymbol: SYBU
name: Syntabulin (Golgi-localized syntaphilin-related protein) (Syntaxin-1-binding protein)
length: 663
go: ENSG00000147642;
sequence:

opentargets:
axon cytoplasm [GO:1904115]; cytoplasmic vesicle [GO:0031410]; dense body [GO:0097433]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; microtubule [GO:0005874]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; syntaxin-1 binding [GO:0017075]; anterograde neuronal dense core vesicle transport [GO:1990048]; axonal transport of mitochondrion [GO:0019896]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; regulation of synaptic activity [GO:0060025]; synapse maturation [GO:0060074]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9NX95-1; Sequence=Displayed; Name=2; IsoId=Q9NX95-2; Sequence=VSP_019719, VSP_019722; Name=3; Synonyms=GOLSYN A; IsoId=Q9NX95-3; Sequence=VSP_019721; Name=4; Synonyms=GOLSYN C; IsoId=Q9NX95-4; Sequence=VSP_019720; Name=5; Synonyms=GOLSYN B; IsoId=Q9NX95-5; Sequence=VSP_019718; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Note=Colocalizes with syntaxin vesicles along microtubules in neuronal processes.; SUBCELLULAR LOCATION: Isoform 3: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: Isoform 4: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: Isoform 5: Golgi apparatus membrane; Single-pass membrane protein.


uniprotID: Q9Y3V2
geneSymbol: RWDD3
reactome: R-HSA-3065678;
pdb: 2EBK;4Y1L;
name: RWD domain-containing protein 3 (RWD domain-containing sumoylation enhancer) (RSUME)
length: 267
go: ENSG00000122481;
snps: rs259358 rs2296308
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; positive regulation of hypoxia-inducible factor-1alpha signaling pathway [GO:1902073]; positive regulation of protein sumoylation [GO:0033235]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9Y3V2-1; Sequence=Displayed; Name=2; IsoId=Q9Y3V2-2; Sequence=VSP_034176, VSP_034177; Name=3; IsoId=Q9Y3V2-3; Sequence=VSP_035411, VSP_035412; Name=4; IsoId=Q9Y3V2-4; Sequence=VSP_035412; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17956732}. Cytoplasm {ECO:0000269|PubMed:17956732}. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000269|PubMed:17956732}.


uniprotID: Q6NW29
geneSymbol: RWDD4
name: RWD domain-containing protein 4 (Protein FAM28A)
length: 188
go: ENSG00000182552;
snps: rs10015804
sequence:
MSANEDQEMELEALRSIYEGDESFRELSPVSFQYRIGENGDPKAFLIEISWTETYPQTPPILSMNAFFNNTISSAVKQSILAKLQEAVEANLGTAMTYTLFEYAKDNKEQFMENHNPINSATSISNIISIETPNTAPSSKKKDKKEQLSKAQKRKLADKTDHKGELPRGWNWVDVVKHLSKTGSKDDE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NW29-1; Sequence=Displayed; Name=2; IsoId=Q6NW29-2; Sequence=VSP_056650; Note=No experimental confirmation available.; 


uniprotID: P57060
geneSymbol: RWDD2B
pdb: 2DAX;
name: RWD domain-containing protein 2B
length: 319
go: ENSG00000156253;
sequence:


uniprotID: Q9H446
geneSymbol: RWDD1
pdb: 2EBM;
name: RWD domain-containing protein 1 (DRG family-regulatory protein 2)
length: 243
go: ENSG00000111832;
sequence:

opentargets:
cytoplasm [GO:0005737]; polysome [GO:0005844]; androgen receptor signaling pathway [GO:0030521]; cell aging [GO:0007569]; cellular response to oxidative stress [GO:0034599]; cellular response to testosterone stimulus [GO:0071394]; cytoplasmic translation [GO:0002181]; positive regulation of androgen receptor activity [GO:2000825]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H446-1; Sequence=Displayed; Name=2; IsoId=Q9H446-2; Sequence=VSP_044500; 


uniprotID: Q9Y2B1
geneSymbol: RXYLT1
length: 443
go: ENSG00000118600;
snps: rs150736997 rs397514544
name:
Ribitol-5-phosphate xylosyltransferase 1 (EC 2.4.2.-) (Transmembrane protein 5) (UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of plasma membrane [GO:0005887]; nucleoplasm [GO:0005654]; ribitol beta-1,4-xylosyltransferase activity [GO:0120053]; protein O-linked mannosylation [GO:0035269]

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25279699, ECO:0000269|PubMed:29477842}; Single-pass type II membrane protein {ECO:0000305}.


uniprotID: Q15413
geneSymbol: RYR3
reactome: R-HSA-2672351;R-HSA-5578775;
pdb: 4ERV;
length: 4870
go: ENSG00000198838;
snps: rs2304380 rs2077268 rs2229116
name:
Ryanodine receptor 3 (RYR-3) (RyR3) (Brain ryanodine receptor-calcium release channel) (Brain-type ryanodine receptor) (Type 3 ryanodine receptor)

sequence:

opentargets:
calcium channel complex [GO:0034704]; cytoplasmic vesicle membrane [GO:0030659]; integral component of membrane [GO:0016021]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum membrane [GO:0033017]; smooth endoplasmic reticulum [GO:0005790]; Z disc [GO:0030018]; calcium ion binding [GO:0005509]; calcium-induced calcium release activity [GO:0048763]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; ryanodine-sensitive calcium-release channel activity [GO:0005219]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cellular response to ATP [GO:0071318]; cellular response to caffeine [GO:0071313]; cellular response to calcium ion [GO:0071277]; cellular response to magnesium ion [GO:0071286]; ion transmembrane transport [GO:0034220]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; protein homotetramerization [GO:0051289]; regulation of cardiac conduction [GO:1903779]; release of sequestered calcium ion into cytosol [GO:0051209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q15413-1; Sequence=Displayed; Name=2; IsoId=Q15413-2; Sequence=VSP_005954; Name=3; IsoId=Q15413-3; Sequence=VSP_005955, VSP_005956; 

location:
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q9TS33}. Note=The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic. {ECO:0000250}.


uniprotID: Q9Y2V3
geneSymbol: RAX
name: Retinal homeobox protein Rx (Retina and anterior neural fold homeobox protein)
length: 346
go: ENSG00000134438;
snps: rs2271733 rs121909127
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; camera-type eye development [GO:0043010]; hypothalamus development [GO:0021854]; limb development [GO:0060173]; pattern specification process [GO:0007389]; positive regulation of transcription by RNA polymerase II [GO:0045944]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2V3-1; Sequence=Displayed; Name=2; IsoId=Q9Y2V3-2; Sequence=VSP_053558, VSP_053559; 


uniprotID: Q8N488
geneSymbol: RYBP
reactome: R-HSA-8939243;R-HSA-8953750;
pdb: 3IXS;
length: 228
name:
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; apoptotic process [GO:0006915]; histone H2A monoubiquitination [GO:0035518]; multicellular organism development [GO:0007275]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of transcription, DNA-templated [GO:0045893]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:11953439, ECO:0000269|PubMed:14765135, ECO:0000269|PubMed:27060496}. Cytoplasm {ECO:0000269|PubMed:11395500, ECO:0000269|PubMed:14765135}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8CCI5}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies (By similarity). {ECO:0000250|UniProtKB:Q8CCI5}.


uniprotID: Q9NUL5
geneSymbol: RYDEN
name: Repressor of yield of DENV protein (RyDEN)
length: 291
go: ENSG00000130813;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; negative regulation of viral genome replication [GO:0045071]; response to interferon-gamma [GO:0034341]; response to type I interferon [GO:0034340]; response to type III interferon [GO:0034342]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9NUL5-1; Sequence=Displayed; Name=2; IsoId=Q9NUL5-2; Sequence=VSP_031272; Note=No experimental confirmation available.; Name=3; IsoId=Q9NUL5-3; Sequence=VSP_031273; Name=4; IsoId=Q9NUL5-4; Sequence=VSP_031274; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26735137}. Nucleus {ECO:0000269|PubMed:26735137}. Note=Predominantly found in the cytoplasm. {ECO:0000269|PubMed:26735137}.


uniprotID: P04271
geneSymbol: S100B
reactome: R-HSA-1251985;R-HSA-445989;R-HSA-879415;R-HSA-933542;
pdb: 1MQ1;1UWO;2H61;2M49;2PRU;3CZT;3D0Y;3D10;3HCM;4XYN;5CSF;5CSI;5CSJ;5CSN;5D7F;
sequence: MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE
length: 92
go: ENSG00000160307;
drug: DB06941;DB07004;DB01373;DB04464;DB00768;DB05343;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9925766}. Nucleus {ECO:0000269|PubMed:9925766}.
name:
Protein S100-B (S-100 protein beta chain) (S-100 protein subunit beta) (S100 calcium-binding protein B)

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ruffle [GO:0001726]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RAGE receptor binding [GO:0050786]; S100 protein binding [GO:0044548]; tau protein binding [GO:0048156]; zinc ion binding [GO:0008270]; astrocyte differentiation [GO:0048708]; axonogenesis [GO:0007409]; cell proliferation [GO:0008283]; cellular response to hypoxia [GO:0071456]; central nervous system development [GO:0007417]; innate immune response [GO:0045087]; learning or memory [GO:0007611]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; negative regulation of skeletal muscle cell differentiation [GO:2001015]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell proliferation [GO:0008284]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of myelination [GO:0031643]; regulation of cell shape [GO:0008360]; regulation of neuronal synaptic plasticity [GO:0048168]; response to glucocorticoid [GO:0051384]; response to methylmercury [GO:0051597]


uniprotID: P34925
geneSymbol: RYK
reactome: R-HSA-201681;R-HSA-4086400;
name: Tyrosine-protein kinase RYK (EC 2.7.10.1)
length: 607
go: ENSG00000163785;
snps: rs1131262 rs55740278 rs746238409
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; frizzled binding [GO:0005109]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; Wnt-activated receptor activity [GO:0042813]; Wnt-protein binding [GO:0017147]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cell proliferation in midbrain [GO:0033278]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; commissural neuron axon guidance [GO:0071679]; corpus callosum development [GO:0022038]; midbrain dopaminergic neuron differentiation [GO:1904948]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of signal transduction [GO:0009968]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; neuron projection development [GO:0031175]; non-canonical Wnt signaling pathway [GO:0035567]; planar cell polarity pathway involved in axon guidance [GO:1904938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAPK cascade [GO:0043410]; signal transduction [GO:0007165]; skeletal system morphogenesis [GO:0048705]; synapse assembly [GO:0007416]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P34925-1; Sequence=Displayed; Name=2; IsoId=P34925-2; Sequence=VSP_005009; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250}.


uniprotID: P60903
geneSymbol: S100A10
reactome: R-HSA-75205;
pdb: 1A4P;1BT6;4DRW;4FTG;4HRE;4HRG;4HRH;
sequence: MPSQMEHAMETMMFTFHKFAGDKGYLTKEDLRVLMEKEFPGFLENQKDPLAVDKIMKDLDQCRDGKVGFQSFFSLIAGLTIACNDYFVVHMKQKGKK
length: 97
go: ENSG00000197747;
name:
Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11)

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; calcium ion binding [GO:0005509]; ion channel binding [GO:0044325]; protein homodimerization activity [GO:0042803]; membrane raft assembly [GO:0001765]; positive regulation of binding [GO:0051099]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein heterotetramerization [GO:0051290]; protein localization to plasma membrane [GO:0072659]; vesicle budding from membrane [GO:0006900]


uniprotID: P31949
geneSymbol: S100A11
reactome: R-HSA-6798695;
pdb: 1V4Z;1V50;2LUC;
length: 105
go: ENSG00000163191;
drug: DB02482;
name:
Protein S100-A11 (Calgizzarin) (Metastatic lymph node gene 70 protein) (MLN 70) (Protein S100-C) (S100 calcium-binding protein A11) [Cleaved into: Protein S100-A11, N-terminally processed]

sequence:
MAKISSPTETERCIESLIAVFQKYAGKDGYNYTLSKTEFLSFMNTELAAFTKNQKDPGVLDRMMKKLDTNSDGQLDFSEFLNLIGGLAMACHDSFLKAVPSQKRT

opentargets:
cell-cell adherens junction [GO:0005913]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; cadherin binding involved in cell-cell adhesion [GO:0098641]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; S100 protein binding [GO:0044548]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA replication [GO:0008156]; neutrophil degranulation [GO:0043312]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18618420}. Nucleus {ECO:0000269|PubMed:18618420}.


uniprotID: P26447
geneSymbol: S100A4
pdb: 1M31;2LNK;2MRD;2Q91;3C1V;3CGA;3KO0;3M0W;3ZWH;4CFQ;4CFR;4ETO;4HSZ;5LPU;
length: 101
go: ENSG00000196154;
drug: DB00831;
name:
Protein S100-A4 (Calvasculin) (Metastasin) (Placental calcium-binding protein) (Protein Mts1) (S100 calcium-binding protein A4)

sequence:
MACPLEKALDVMVSTFHKYSGKEGDKFKLNKSELKELLTRELPSFLGKRTDEAAFQKLMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGFPDKQPRKK

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; RAGE receptor binding [GO:0050786]; RNA binding [GO:0003723]; transition metal ion binding [GO:0046914]; epithelial to mesenchymal transition [GO:0001837]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]


uniprotID: P80511
geneSymbol: S100A12
reactome: R-HSA-445989;R-HSA-6798695;R-HSA-879415;R-HSA-933542;
pdb: 1E8A;1GQM;1ODB;2M9G;2WC8;2WCB;2WCE;2WCF;
sequence: MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIALKAAHYHTHKE
length: 92
go: ENSG00000163221;
drug: DB01025;DB00768;
name:
Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; calcium ion binding [GO:0005509]; copper ion binding [GO:0005507]; RAGE receptor binding [GO:0050786]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytokine secretion [GO:0050663]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; killing of cells of other organism [GO:0031640]; mast cell activation [GO:0045576]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; neutrophil degranulation [GO:0043312]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; xenobiotic metabolic process [GO:0006805]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.


uniprotID: A0AV02
geneSymbol: SLC12A8
name: Solute carrier family 12 member 8 (Cation-chloride cotransporter 9)
length: 714
go: ENSG00000221955;
snps: rs2993631 rs863642 rs621383 rs6773138 rs2981482
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
cell [GO:0005623]; integral component of membrane [GO:0016021]; potassium:chloride symporter activity [GO:0015379]; cell volume homeostasis [GO:0006884]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; potassium ion homeostasis [GO:0055075]; potassium ion import [GO:0010107]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=A0AV02-1; Sequence=Displayed; Name=2; IsoId=A0AV02-2; Sequence=VSP_028330; Note=No experimental confirmation available.; Name=3; IsoId=A0AV02-3; Sequence=VSP_028329, VSP_028331; Note=No experimental confirmation available.; Name=4; IsoId=A0AV02-4; Sequence=VSP_028328, VSP_028332; Note=No experimental confirmation available.; Name=5; IsoId=A0AV02-5; Sequence=VSP_028327; Note=No experimental confirmation available.; 


uniprotID: Q8N1F8
geneSymbol: STK11IP
reactome: R-HSA-6798695;
name: Serine/threonine-protein kinase 11-interacting protein (LKB1-interacting protein 1)
length: 1088
go: ENSG00000144589;
snps: rs17855575 rs17855576 rs673951 rs627530 rs17853279
sequence:

opentargets:
azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; lysosomal membrane [GO:0005765]; protein kinase binding [GO:0019901]; structural constituent of cytoskeleton [GO:0005200]; neutrophil degranulation [GO:0043312]; protein localization [GO:0008104]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11741830}. Note=Some cells show granular or punctuate expression. Colocalizes with STK11/LKB1 and SMAD4 in granular or punctuate structures.


uniprotID: P55011
geneSymbol: SLC12A2
reactome: R-HSA-426117;
length: 1212
go: ENSG00000064651;
drug: DB00887;DB00761;DB01325;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Solute carrier family 12 member 2 (Basolateral Na-K-Cl symporter) (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ammonium transmembrane transporter activity [GO:0008519]; potassium:chloride symporter activity [GO:0015379]; protein kinase binding [GO:0019901]; sodium ion transmembrane transporter activity [GO:0015081]; sodium:chloride symporter activity [GO:0015378]; sodium:potassium:chloride symporter activity [GO:0008511]; aging [GO:0007568]; ammonium transport [GO:0015696]; cell volume homeostasis [GO:0006884]; cellular response to chemokine [GO:1990869]; chloride ion homeostasis [GO:0055064]; chloride transmembrane transport [GO:1902476]; gamma-aminobutyric acid signaling pathway [GO:0007214]; hyperosmotic response [GO:0006972]; ion transport [GO:0006811]; positive regulation of cell volume [GO:0045795]; potassium ion homeostasis [GO:0055075]; potassium ion import [GO:0010107]; sodium ion transmembrane transport [GO:0035725]; T cell chemotaxis [GO:0010818]; transepithelial ammonium transport [GO:0070634]; transepithelial chloride transport [GO:0030321]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P55011-1; Sequence=Displayed; Name=2; IsoId=P55011-3; Sequence=VSP_006105; 


uniprotID: Q92503
geneSymbol: SEC14L1
name: SEC14-like protein 1
length: 715
go: ENSG00000129657;
snps: rs1049416 rs1049422 rs1049423 rs673918
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; molecular function regulator [GO:0098772]; RIG-I binding [GO:0039552]; choline transport [GO:0015871]; innate immune response [GO:0045087]; negative regulation of RIG-I signaling pathway [GO:0039536]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q92503-1; Sequence=Displayed; Name=2; IsoId=Q92503-2; Sequence=VSP_040118; Name=3; IsoId=Q92503-3; Sequence=VSP_040117; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}. Golgi apparatus {ECO:0000269|PubMed:17092608}.


uniprotID: Q9UDX3
geneSymbol: SEC14L4
pdb: 4TLG;
name: SEC14-like protein 4 (Tocopherol-associated protein 3)
length: 406
go: ENSG00000133488;
opentargets: lipid binding [GO:0008289]
drug: DB00163;
snps: rs9608956 rs9606739 rs17738540 rs17738527
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UDX3-1; Sequence=Displayed; Name=2; IsoId=Q9UDX3-2; Sequence=VSP_045200; Note=No experimental confirmation available.; 


uniprotID: O43304
geneSymbol: SEC14L5
name: SEC14-like protein 5
length: 696
go: ENSG00000103184;
sequence:


uniprotID: B5MCN3
geneSymbol: SEC14L6
name: Putative SEC14-like protein 6
length: 397
go: ENSG00000214491;
sequence:


uniprotID: Q8TCC7
geneSymbol: SLC22A8
reactome: R-HSA-561048;
name: Solute carrier family 22 member 8 (Organic anion transporter 3) (hOAT3)
length: 542
go: ENSG00000149452;
snps: rs11568479 rs45566039 rs11568493 rs11568492 rs45438191 rs11568482 rs749944923 rs11568486
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; inorganic anion exchanger activity [GO:0005452]; response to toxic substance [GO:0009636]

drug:
DB00787;DB00718;DB00437;DB00345;DB00168;DB09060;DB00181;DB03793;DB01053;DB00887;DB04519;DB01414;DB01140;DB00456;DB01326;DB01327;DB01329;DB00493;DB01212;DB00567;DB02659;DB01597;DB00501;DB00286;DB02527;DB08912;DB04133;DB05804;DB00586;DB00390;DB01160;DB00917;DB00254;DB09272;DB00584;DB00783;DB00927;DB00695;DB01004;DB03553;DB00536;DB01050;DB00328;DB01009;DB00583;DB00279;DB01583;DB01065;DB01033;DB00563;DB06710;DB01017;DB01051;DB00198;DB01092;DB03902;DB00595;DB00812;DB00554;DB00175;DB01032;DB00908;DB00863;DB00936;DB06335;DB00139;DB04348;DB00300;DB00469;DB00624;DB00759;DB08837;DB01650;DB08844;DB00577;DB00313;DB00495;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8TCC7-1; Sequence=Displayed; Name=2; IsoId=Q8TCC7-2; Sequence=VSP_022565; Note=No experimental confirmation available.; Name=5; IsoId=Q8TCC7-5; Sequence=VSP_045824; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCC7-3; Sequence=VSP_022562, VSP_022563, VSP_022564; Note=No experimental confirmation available.; Name=4; IsoId=Q8TCC7-4; Sequence=VSP_045272; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC) (By similarity). {ECO:0000250}.


uniprotID: Q8N4F4
geneSymbol: SLC22A24
name: Solute carrier family 22 member 24
length: 322
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; ion transport [GO:0006811]; transmembrane transport [GO:0055085]


uniprotID: Q8IVM8
geneSymbol: SLC22A9
name: Solute carrier family 22 member 9 (Organic anion transporter 7)
length: 553
go: ENSG00000149742;
snps: rs770073076
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; anion:anion antiporter activity [GO:0015301]; short-chain fatty acid transmembrane transporter activity [GO:0015636]; sodium-independent organic anion transmembrane transporter activity [GO:0015347]; hormone transport [GO:0009914]; short-chain fatty acid import [GO:0015913]; sodium-independent organic anion transport [GO:0043252]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IVM8-1; Sequence=Displayed; Name=2; IsoId=Q8IVM8-2; Sequence=VSP_036710, VSP_036711; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:17393504}; Multi-pass membrane protein {ECO:0000269|PubMed:17393504}. Note=Enriched at the sinusoidal part of the plasma membrane.


uniprotID: A6NKX4
geneSymbol: SLC22A31
name: Putative solute carrier family 22 member 31
length: 556
go: ENSG00000259803;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: Q9Y226
geneSymbol: SLC22A13
reactome: R-HSA-197264;
name: Solute carrier family 22 member 13 (Organic cation transporter-like 3) (ORCTL-3)
length: 551
go: ENSG00000172940;
snps: rs17853496 rs17857080
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; nicotinate transmembrane transporter activity [GO:0090416]; organic cation transmembrane transporter activity [GO:0015101]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; nicotinate transport [GO:2001142]; organic cation transport [GO:0015695]; urate transport [GO:0015747]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y226-1; Sequence=Displayed; Name=2; IsoId=Q9Y226-2; Sequence=VSP_017830; 


uniprotID: Q9Y267
geneSymbol: SLC22A14
name: Solute carrier family 22 member 14 (Organic cation transporter-like 4) (ORCTL-4)
length: 594
go: ENSG00000144671;
snps: rs9847584 rs2073714 rs194685 rs1078846 rs818818 rs818817 rs34256819 rs2070492 rs240033
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; organic cation transmembrane transporter activity [GO:0015101]; organic cation transport [GO:0015695]


uniprotID: Q86VW1
geneSymbol: SLC22A16
reactome: R-HSA-549127;
length: 577
go: ENSG00000004809;
drug: DB00997;DB00583;
snps: rs714368 rs723685 rs12210538 rs35948062
name:
Solute carrier family 22 member 16 (Carnitine transporter 2) (CT2) (Fly-like putative transporter 2) (FLIPT2) (Flipt 2) (Organic cation transporter OKB1) (Organic cation/carnitine transporter 6)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amine transmembrane transporter activity [GO:0005275]; carnitine transmembrane transporter activity [GO:0015226]; organic cation transmembrane transporter activity [GO:0015101]; acid secretion [GO:0046717]; carnitine transport [GO:0015879]; cell differentiation [GO:0030154]; flagellated sperm motility [GO:0030317]; multicellular organism development [GO:0007275]; organic cation transport [GO:0015695]; single fertilization [GO:0007338]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86VW1-1; Sequence=Displayed; Name=2; IsoId=Q86VW1-2; Sequence=VSP_031336, VSP_031337; Name=3; IsoId=Q86VW1-3; Sequence=VSP_031338; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:12089149}. Note=Detected in the plasma membrane of Sertoli cells and in the luminal membrane of epithelial cells in the epididymis.


uniprotID: Q86VD7
geneSymbol: SLC25A42
name: Mitochondrial coenzyme A transporter SLC25A42 (Solute carrier family 25 member 42)
length: 318
go: ENSG00000181035;
snps: rs17854359 rs17854358
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; adenosine-diphosphatase activity [GO:0043262]; ADP transmembrane transporter activity [GO:0015217]; AMP transmembrane transporter activity [GO:0080122]; ATP transmembrane transporter activity [GO:0005347]; coenzyme A transmembrane transporter activity [GO:0015228]; ADP transport [GO:0015866]; AMP transport [GO:0080121]; ATP transport [GO:0015867]; coenzyme A transmembrane transport [GO:0035349]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:19429682}; Multi-pass membrane protein {ECO:0000269|PubMed:19429682}.


uniprotID: Q8WUT9
geneSymbol: SLC25A43
name: Solute carrier family 25 member 43
length: 341
go: ENSG00000077713;
snps: rs3810755
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; transmembrane transporter activity [GO:0022857]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WUT9-1; Sequence=Displayed; Name=2; IsoId=Q8WUT9-2; Sequence=VSP_026245; Note=No experimental confirmation available.; 


uniprotID: Q6PIV7
geneSymbol: SLC25A34
name: Solute carrier family 25 member 34
length: 304
go: ENSG00000162461;
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; blastocyst hatching [GO:0001835]


uniprotID: Q96AG3
geneSymbol: SLC25A46
name: Solute carrier family 25 member 46
length: 418
go: ENSG00000164209;
snps: rs200725073 rs1057518750 rs1057518748 rs746681765
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; mitochondrial membrane fission [GO:0090149]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96AG3-1; Sequence=Displayed; Name=2; IsoId=Q96AG3-2; Sequence=VSP_056112; Note=No experimental confirmation available.; Name=3; IsoId=Q96AG3-3; Sequence=VSP_056351; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26168012}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9Y285
geneSymbol: FARSA
reactome: R-HSA-379716;
pdb: 3L4G;
length: 508
go: ENSG00000179115;
drug: DB00120;
snps: rs35087277
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q505J8}.
name:
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phenylalanine-tRNA ligase complex [GO:0009328]; ATP binding [GO:0005524]; phenylalanine-tRNA ligase activity [GO:0004826]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; phenylalanyl-tRNA aminoacylation [GO:0006432]; protein heterotetramerization [GO:0051290]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y285-1; Sequence=Displayed; Name=2; IsoId=Q9Y285-2; Sequence=VSP_056196; Note=No experimental confirmation available.; 


uniprotID: Q3SY17
geneSymbol: SLC25A52
name: Solute carrier family 25 member 52 (Mitochondrial carrier triple repeat protein 2)
length: 297
opentargets: integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]
snps: rs3859364
sequence:

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q5TZJ5
geneSymbol: SPATA31A1
name: Spermatogenesis-associated protein 31A1 (Protein FAM75A1)
length: 1347
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q5VU36
geneSymbol: SPATA31A5
name: Spermatogenesis-associated protein 31A5 (Protein FAM75A5)
length: 1347
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9H2B4
geneSymbol: SLC26A1
reactome: R-HSA-174362;R-HSA-427601;
name: Sulfate anion transporter 1 (SAT-1) (Solute carrier family 26 member 1)
length: 701
go: ENSG00000145217;
snps: rs142573758 rs139024319 rs148832260 rs3796622
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; chloride transport [GO:0006821]; ion transport [GO:0006811]; oxalate transport [GO:0019532]; regulation of membrane potential [GO:0042391]; sulfate transport [GO:0008272]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H2B4-1; Sequence=Displayed; Name=2; IsoId=Q9H2B4-2; Sequence=VSP_043671, VSP_043672; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P58735}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P45380}.


uniprotID: P50443
geneSymbol: SLC26A2
reactome: R-HSA-174362;R-HSA-3560792;R-HSA-427601;
name: Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
length: 739
go: ENSG00000155850;
sequence:

opentargets:
apical plasma membrane [GO:0016324]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; ion transport [GO:0006811]; ossification [GO:0001503]; regulation of membrane potential [GO:0042391]; sulfate transmembrane transport [GO:1902358]

snps:
rs104893917 rs1419613966 rs104893915 rs104893920 rs104893921 rs30832 rs104893924 rs104893916 rs3776070 rs104893918 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7923357}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: P78381
geneSymbol: SLC35A2
reactome: R-HSA-5619072;R-HSA-727802;
length: 396
go: ENSG00000102100;
snps: rs587777436 rs587776961
location: SUBCELLULAR LOCATION: Golgi apparatus membrane; Multi-pass membrane protein.
name:
UDP-galactose translocator (Solute carrier family 35 member A2) (UDP-galactose transporter) (UDP-Gal-Tr) (UGT)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of Golgi membrane [GO:0030173]; nucleus [GO:0005634]; UDP-galactose transmembrane transporter activity [GO:0005459]; carbohydrate transport [GO:0008643]; galactose metabolic process [GO:0006012]; UDP-galactose transmembrane transport [GO:0072334]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=UGT2; IsoId=P78381-1; Sequence=Displayed; Name=2; Synonyms=UGT1; IsoId=P78381-2; Sequence=VSP_003728; Name=3; IsoId=P78381-3; Sequence=VSP_042029; Name=4; IsoId=P78381-4; Sequence=VSP_054335, VSP_003728; Note=No experimental confirmation available.; Name=5; IsoId=P78381-5; Sequence=VSP_055197, VSP_003728; Note=No experimental confirmation available.; 


uniprotID: P40879
geneSymbol: SLC26A3
reactome: R-HSA-427601;R-HSA-5619085;
length: 764
go: ENSG00000091138;
name:
Chloride anion exchanger (Down-regulated in adenoma) (Protein DRA) (Solute carrier family 26 member 3)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; sperm midpiece [GO:0097225]; anion:anion antiporter activity [GO:0015301]; bicarbonate transmembrane transporter activity [GO:0015106]; chloride transmembrane transporter activity [GO:0015108]; DNA-binding transcription factor activity [GO:0003700]; inorganic anion exchanger activity [GO:0005452]; oxalate transmembrane transporter activity [GO:0019531]; secondary active sulfate transmembrane transporter activity [GO:0008271]; sulfate transmembrane transporter activity [GO:0015116]; transcription coregulator activity [GO:0003712]; transporter activity [GO:0005215]; anion transport [GO:0006820]; cellular response to cAMP [GO:0071320]; excretion [GO:0007588]; intracellular pH elevation [GO:0051454]; ion transport [GO:0006811]; membrane hyperpolarization [GO:0060081]; regulation of membrane potential [GO:0042391]; sperm capacitation [GO:0048240]

snps:
rs10280704 rs386833479 rs121913030 rs386833480 rs386833481 rs386833481 rs386833483 rs386833484 rs386833487 rs386833488 rs386833489 rs34407351 rs386833491 rs386833444 rs386833446 rs143839547 rs763669046 rs386833454 rs386833457 rs386833462 rs386833463 rs386833467 rs2301635 rs140426439 rs121913031 rs35342296 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22159084}; Multi-pass membrane protein {ECO:0000269|PubMed:22159084}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.


uniprotID: Q5K4L6
geneSymbol: SLC27A3
reactome: R-HSA-75876;
length: 730
go: ENSG00000143554;
snps: rs34527123 rs35102232
name:
Long-chain fatty acid transport protein 3 (FATP-3) (Fatty acid transport protein 3) (EC 6.2.1.-) (Solute carrier family 27 member 3) (Very long-chain acyl-CoA synthetase homolog 3) (VLCS-3)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; long-chain fatty acid transporter activity [GO:0005324]; long-chain fatty acid-CoA ligase activity [GO:0004467]; nucleotide binding [GO:0000166]; very long-chain fatty acid-CoA ligase activity [GO:0031957]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5K4L6-1; Sequence=Displayed; Name=2; IsoId=Q5K4L6-2; Sequence=VSP_016218; Name=3; IsoId=Q5K4L6-3; Sequence=VSP_036534, VSP_036535; 


uniprotID: Q14542
geneSymbol: SLC29A2
reactome: R-HSA-83936;
length: 456
go: ENSG00000174669;
drug: DB00900;DB00898;DB00441;DB01033;DB00943;DB00495;
snps: rs8187643 rs8187644 rs8187648
name:
Equilibrative nucleoside transporter 2 (36 kDa nucleolar protein HNP36) (Delayed-early response protein 12) (Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter) (Equilibrative NBMPR-insensitive nucleoside transporter) (Hydrophobic nucleolar protein, 36 kDa) (Nucleoside transporter, ei-type) (Solute carrier family 29 member 2)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of plasma membrane [GO:0005887]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; nucleoside transmembrane transporter activity [GO:0005337]; adenine transport [GO:0015853]; cell proliferation [GO:0008283]; guanine transport [GO:0015854]; hypoxanthine transport [GO:0035344]; neurotransmitter reuptake [GO:0098810]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside transport [GO:0015858]; thymine transport [GO:0035364]; uridine transport [GO:0015862]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Long; IsoId=Q14542-1; Sequence=Displayed; Name=2; Synonyms=Short, HNP36; IsoId=Q14542-2; Sequence=VSP_040728, VSP_040729; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q14542-3; Sequence=VSP_040730, VSP_040731; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Nucleus membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells.


uniprotID: P0C7Q5
geneSymbol: SLC35G4
name: Putative solute carrier family 35 member G4 (Acyl-malonyl-condensing enzyme 1-like protein 1)
length: 338
go: ENSG00000236396;
opentargets: integral component of membrane [GO:0016021]
snps: rs8087447
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q96KT7
geneSymbol: SLC35G5
name: Solute carrier family 35 member G5 (Acyl-malonyl-condensing enzyme 1-like protein 2)
length: 338
go: ENSG00000177710;
opentargets: integral component of membrane [GO:0016021]
snps: rs6990563 rs12681991
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: L0R6Q1
geneSymbol: SLC35A4
name: SLC35A4 upstream open reading frame protein
length: 103
go: ENSG00000176087;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
sequence:
MADDKDSLPKLKDLAFLKNQLESLQRRVEDEVNSGVGQDGSLLSSPFLKGFLAGYVVAKLRASAVLGFAVGTCTGIYAAQAYAVPNVEKTLRDYLQLLRKGPD

opentargets:
integral component of membrane [GO:0016021]; positive regulation of translation in response to stress [GO:0032056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=2; Synonyms=uORF {ECO:0000303|PubMed:25621764}; IsoId=L0R6Q1-1; Sequence=Displayed; Note=Product of the upstream open reading frame of this bicistronic gene. This may be the major product of the gene under normal conditions. {ECO:0000269|PubMed:25621764}; Name=1; IsoId=Q96G79-1; Sequence=External; 


uniprotID: Q9NR83
geneSymbol: SLC2A4RG
length: 387
go: ENSG00000125520;
snps: rs8957
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.
name:
SLC2A4 regulator (GLUT4 enhancer factor) (GEF) (Huntington disease gene regulatory region-binding protein 1) (HDBP-1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NR83-1; Sequence=Displayed; Name=2; IsoId=Q9NR83-4; Sequence=VSP_055908; Note=No experimental confirmation available.; Name=3; IsoId=Q9NR83-3; Sequence=VSP_055909; Note=No experimental confirmation available.; 


uniprotID: Q6ICL7
geneSymbol: SLC35E4
name: Solute carrier family 35 member E4
length: 350
go: ENSG00000100036;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ICL7-1; Sequence=Displayed; Name=2; IsoId=Q6ICL7-2; Sequence=VSP_027480, VSP_027481; 


uniprotID: Q8IZM9
geneSymbol: SLC38A6
length: 456
go: ENSG00000139974;
snps: rs976272
name:
Probable sodium-coupled neutral amino acid transporter 6 (N-system amino acid transporter 1) (NAT-1) (Na(+)-coupled neutral amino acid transporter 6) (Solute carrier family 38 member 6)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transmembrane transport [GO:0003333]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IZM9-1; Sequence=Displayed; Name=2; IsoId=Q8IZM9-2; Sequence=VSP_029563; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:G3UVW3}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with synaptotagmins and SNAP25. {ECO:0000250|UniProtKB:G3UVW3}.


uniprotID: Q6YBV0
geneSymbol: SLC36A4
reactome: R-HSA-352230;R-HSA-71240;
length: 504
go: ENSG00000180773;
snps: rs17854446 rs17854445 rs17854443
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Proton-coupled amino acid transporter 4 (Proton/amino acid transporter 4) (Solute carrier family 36 member 4)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; L-alanine transmembrane transporter activity [GO:0015180]; L-proline transmembrane transporter activity [GO:0015193]; L-tryptophan transmembrane transporter activity [GO:0015196]; symporter activity [GO:0015293]; amino acid transmembrane transport [GO:0003333]; L-alanine transport [GO:0015808]; L-proline import across plasma membrane [GO:1904271]; L-tryptophan transmembrane transport [GO:1904556]; proline transport [GO:0015824]; tryptophan transport [GO:0015827]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6YBV0-1; Sequence=Displayed; Name=2; IsoId=Q6YBV0-2; Sequence=VSP_028959; Note=No experimental confirmation available.; 


uniprotID: Q96QD8
geneSymbol: SLC38A2
reactome: R-HSA-210500;R-HSA-352230;
length: 506
go: ENSG00000134294;
snps: rs11183450
name:
Sodium-coupled neutral amino acid transporter 2 (Amino acid transporter A2) (Protein 40-9-1) (Solute carrier family 38 member 2) (System A amino acid transporter 2) (System A transporter 1) (System N amino acid transporter 2)

sequence:

opentargets:
axon [GO:0030424]; brush border [GO:0005903]; dendrite [GO:0030425]; integral component of plasma membrane [GO:0005887]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; amino acid transmembrane transporter activity [GO:0015171]; L-glutamine transmembrane transporter activity [GO:0015186]; symporter activity [GO:0015293]; alanine transport [GO:0032328]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; cellular response to amino acid starvation [GO:0034198]; cellular response to mechanical stimulus [GO:0071260]; cerebral cortex development [GO:0021987]; female pregnancy [GO:0007565]; glutamate secretion [GO:0014047]; glycine betaine transport [GO:0031460]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96QD8-1; Sequence=Displayed; Name=2; IsoId=Q96QD8-2; Sequence=VSP_029553, VSP_029554; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}; Multi-pass membrane protein {ECO:0000269|PubMed:15561425, ECO:0000269|PubMed:16616430}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. {ECO:0000250}.


uniprotID: Q9HBR0
geneSymbol: SLC38A10
name: Putative sodium-coupled neutral amino acid transporter 10 (Solute carrier family 38 member 10)
length: 1119
go: ENSG00000157637;
snps: rs35546507 rs2725405
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; amino acid transmembrane transporter activity [GO:0015171]; amino acid transmembrane transport [GO:0003333]; bone development [GO:0060348]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9HBR0-1; Sequence=Displayed; Name=2; IsoId=Q9HBR0-2; Sequence=VSP_031324, VSP_031327; Name=3; IsoId=Q9HBR0-3; Sequence=VSP_031323, VSP_031325, VSP_031326; Note=No experimental confirmation available.; 


uniprotID: Q9C0K1
geneSymbol: SLC39A8
reactome: R-HSA-442380;
length: 460
go: ENSG00000138821;
snps: rs373562040 rs778210210 rs779241085 rs864309660 rs864309659 rs13107325
name:
Zinc transporter ZIP8 (BCG-induced integral membrane protein in monocyte clone 103 protein) (LIV-1 subfamily of ZIP zinc transporter 6) (LZT-Hs6) (Solute carrier family 39 member 8) (Zrt- and Irt-like protein 8) (ZIP-8)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; cadmium ion transmembrane transport [GO:0070574]; cellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transport [GO:0006829]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9C0K1-1; Sequence=Displayed; Name=2; IsoId=Q9C0K1-2; Sequence=VSP_029884, VSP_029885; Note=No experimental confirmation available.; Name=3; IsoId=Q9C0K1-3; Sequence=VSP_043675; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Associated with the lysosomal/endosomal compartment following transfection. {ECO:0000269|PubMed:12504855}.


uniprotID: Q969I6
geneSymbol: SLC38A4
reactome: R-HSA-352230;
length: 547
go: ENSG00000139209;
snps: rs2429467 rs11183610
name:
Sodium-coupled neutral amino acid transporter 4 (Amino acid transporter A3) (Na(+)-coupled neutral amino acid transporter 4) (Solute carrier family 38 member 4) (System A amino acid transporter 3) (System N amino acid transporter 3)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; symporter activity [GO:0015293]; amino acid transmembrane transport [GO:0003333]; amino acid transport [GO:0006865]; sodium ion transport [GO:0006814]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}; Multi-pass membrane protein {ECO:0000269|PubMed:11414754, ECO:0000269|PubMed:16148032}.


uniprotID: Q9NUM3
geneSymbol: SLC39A9
name: Zinc transporter ZIP9 (Solute carrier family 39 member 9) (Zrt- and Irt-like protein 9) (ZIP-9)
length: 307
go: ENSG00000029364;
snps: rs2296723 rs2232059 rs17855898
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; metal ion transmembrane transporter activity [GO:0046873]; zinc ion transport [GO:0006829]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NUM3-1; Sequence=Displayed; Name=2; IsoId=Q9NUM3-2; Sequence=VSP_027302; Name=3; IsoId=Q9NUM3-3; Sequence=VSP_054057, VSP_054058; 


uniprotID: Q9BRY0
geneSymbol: SLC39A3
reactome: R-HSA-442380;
name: Zinc transporter ZIP3 (Solute carrier family 39 member 3) (Zrt- and Irt-like protein 3) (ZIP-3)
length: 314
go: ENSG00000141873;
snps: rs11539244 rs35594294
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; cell morphogenesis [GO:0000902]; embryonic cranial skeleton morphogenesis [GO:0048701]; in utero embryonic development [GO:0001701]; limb development [GO:0060173]; T cell homeostasis [GO:0043029]; zinc ion transmembrane transport [GO:0071577]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BRY0-1; Sequence=Displayed; Name=2; IsoId=Q9BRY0-2; Sequence=VSP_029920, VSP_029921; 


uniprotID: Q8N1S5
geneSymbol: SLC39A11
name: Zinc transporter ZIP11 (Solute carrier family 39 member 11) (Zrt- and Irt-like protein 11) (ZIP-11)
length: 342
go: ENSG00000133195;
snps: rs2466517
sequence:

opentargets:
cytoplasm [GO:0005737]; fungal-type vacuole membrane [GO:0000329]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; zinc ion transmembrane transporter activity [GO:0005385]; zinc ion transmembrane transport [GO:0071577]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N1S5-1; Sequence=Displayed; Name=2; IsoId=Q8N1S5-2; Sequence=VSP_028976; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BWY7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BWY7}. Nucleus {ECO:0000250|UniProtKB:Q8BWY7}. Cytoplasm {ECO:0000250|UniProtKB:Q8BWY7}. Golgi apparatus {ECO:0000250|UniProtKB:Q8BWY7}.


uniprotID: Q8IVJ1
geneSymbol: SLC41A1
reactome: R-HSA-425410;
name: Solute carrier family 41 member 1
length: 513
go: ENSG00000133065;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; divalent inorganic cation transmembrane transporter activity [GO:0072509]; magnesium ion transmembrane transporter activity [GO:0015095]; magnesium:sodium antiporter activity [GO:0061768]; transmembrane transporter activity [GO:0022857]; cellular magnesium ion homeostasis [GO:0010961]; cellular response to magnesium ion [GO:0071286]; divalent metal ion transport [GO:0070838]; magnesium ion transmembrane transport [GO:1903830]; magnesium ion transport [GO:0015693]


uniprotID: Q15043
geneSymbol: SLC39A14
reactome: R-HSA-442380;
length: 492
go: ENSG00000104635;
snps: rs896378 rs879253763 rs879253766 rs750281602
name:
Zinc transporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ferrous iron transmembrane transporter activity [GO:0015093]; manganese ion transmembrane transporter activity [GO:0005384]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; zinc ion import across plasma membrane [GO:0071578]; zinc ion transmembrane transport [GO:0071577]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q15043-1; Sequence=Displayed; Name=2; IsoId=Q15043-2; Sequence=VSP_029728; Note=No experimental confirmation available.; Name=3; IsoId=Q15043-3; Sequence=VSP_040139; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27231142, ECO:0000269|PubMed:29621230}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:27231142}. Cell projection, lamellipodium {ECO:0000269|PubMed:12659941, ECO:0000269|PubMed:15642354}. Note=Localized to the plasma membrane and also found colocalized with F-actin concentrated on lamellipodiae. {ECO:0000269|PubMed:12659941, ECO:0000269|PubMed:15642354, ECO:0000269|PubMed:27231142}.


uniprotID: Q8IY50
geneSymbol: SLC35F3
name: Putative thiamine transporter SLC35F3 (Solute carrier family 35 member F3)
length: 421
go: ENSG00000183780;
opentargets: integral component of membrane [GO:0016021]; thiamine transport [GO:0015888]
snps: rs17853780
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IY50-1; Sequence=Displayed; Name=2; IsoId=Q8IY50-2; Sequence=VSP_028850; Note=No experimental confirmation available.; 


uniprotID: A4IF30
geneSymbol: SLC35F4
name: Solute carrier family 35 member F4
length: 521
go: ENSG00000151812;
opentargets: integral component of membrane [GO:0016021]; transmembrane transporter activity [GO:0022857]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A4IF30-1; Sequence=Displayed; Name=2; IsoId=A4IF30-2; Sequence=VSP_029669; Note=No experimental confirmation available.; 


uniprotID: Q9Y2W3
geneSymbol: SLC45A1
length: 782
go: ENSG00000162426;
snps: rs141816307 rs781036625 rs150539474
name:
Proton-associated sugar transporter A (PAST-A) (Deleted in neuroblastoma 5 protein) (DNb-5) (Solute carrier family 45 member 1)

sequence:

opentargets:
integral component of membrane [GO:0016021]; symporter activity [GO:0015293]; glucose transmembrane transport [GO:1904659]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:28434495}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9H9S3
geneSymbol: SEC61A2
reactome: R-HSA-1236974;R-HSA-1799339;R-HSA-381038;
name: Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha-2)
length: 476
go: ENSG00000065665;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; Sec61 translocon complex [GO:0005784]; protein transmembrane transporter activity [GO:0008320]; ribosome binding [GO:0043022]; signal sequence binding [GO:0005048]; posttranslational protein targeting to endoplasmic reticulum membrane [GO:0006620]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H9S3-1; Sequence=Displayed; Name=2; IsoId=Q9H9S3-2; Sequence=VSP_010472; Note=No experimental confirmation available.; Name=3; IsoId=Q9H9S3-3; Sequence=VSP_046380; Note=No experimental confirmation available.; 


uniprotID: Q9Y6R1
geneSymbol: SLC4A4
reactome: R-HSA-425381;R-HSA-5619054;
pdb: 6CAA;
length: 1079
go: ENSG00000080493;
drug: DB01390;
snps: rs121908856 rs121908857
name:
Electrogenic sodium bicarbonate cotransporter 1 (Sodium bicarbonate cotransporter) (Na(+)/HCO3(-) cotransporter) (Solute carrier family 4 member 4) (kNBC1)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; inorganic anion exchanger activity [GO:0005452]; sodium:bicarbonate symporter activity [GO:0008510]; bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=hcNBC, hhNBC, hNBC1, pNBC, pNCB1, pNBC-1, NBC1b; IsoId=Q9Y6R1-1; Sequence=Displayed; Name=2; Synonyms=hkNBC, hkNBCe1, kNBC, kNBC1, kNBC-1, NBC1a; IsoId=Q9Y6R1-2; Sequence=VSP_016704, VSP_016705; Name=3; IsoId=Q9Y6R1-3; Sequence=VSP_016704, VSP_016705, VSP_016706, VSP_016707; Name=4; IsoId=Q9Y6R1-4; Sequence=VSP_016708; Name=5; IsoId=Q9Y6R1-5; Sequence=VSP_041003; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12907161, ECO:0000269|PubMed:15273250, ECO:0000269|PubMed:16636648, ECO:0000269|PubMed:17661077, ECO:0000305|PubMed:12534288, ECO:0000305|PubMed:29500354}; Multi-pass membrane protein {ECO:0000269|PubMed:12534288, ECO:0000305|PubMed:29500354}.


uniprotID: Q96FL8
geneSymbol: SLC47A1
reactome: R-HSA-425366;
name: Multidrug and toxin extrusion protein 1 (MATE-1) (hMATE-1) (Solute carrier family 47 member 1)
length: 570
go: ENSG00000142494;
drug: DB00787;DB01237;DB00567;DB00501;DB00331;DB00877;
snps: rs35790011
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; drug transmembrane transporter activity [GO:0015238]; drug:proton antiporter activity [GO:0015307]; drug transmembrane transport [GO:0006855]; organic cation transport [GO:0015695]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96FL8-1; Sequence=Displayed; Name=2; IsoId=Q96FL8-2; Sequence=VSP_029903, VSP_029904; Note=No experimental confirmation available.; Name=3; IsoId=Q96FL8-3; Sequence=VSP_029905; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}; Multi-pass membrane protein {ECO:0000269|PubMed:16330770, ECO:0000269|PubMed:16641166}. Note=Predominantly localized at the plasma membrane but also found in intracellular organelles.


uniprotID: Q9BY07
geneSymbol: SLC4A5
reactome: R-HSA-425381;
name: Electrogenic sodium bicarbonate cotransporter 4 (NBCe2) (Solute carrier family 4 member 5)
length: 1137
go: ENSG00000188687;
drug: DB01390;
snps: rs17009792 rs55651232
sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; anion:anion antiporter activity [GO:0015301]; inorganic anion exchanger activity [GO:0005452]; sodium:bicarbonate symporter activity [GO:0008510]; bicarbonate transport [GO:0015701]; cerebrospinal fluid secretion [GO:0033326]; epithelial cell development [GO:0002064]; mitochondrion distribution [GO:0048311]; regulation of gene expression [GO:0010468]; regulation of intracellular pH [GO:0051453]; regulation of systemic arterial blood pressure [GO:0003073]; renal system process [GO:0003014]; retina development in camera-type eye [GO:0060041]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1 {ECO:0000269|PubMed:11087115}; Synonyms=NBC4a {ECO:0000269|PubMed:11087115}; IsoId=Q9BY07-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:10978526, ECO:0000269|PubMed:11087115}; Synonyms=NBC4b {ECO:0000269|PubMed:11087115}; IsoId=Q9BY07-2; Sequence=VSP_052778; Name=3 {ECO:0000269|PubMed:11788353}; Synonyms=NBC4c {ECO:0000269|PubMed:11788353}; IsoId=Q9BY07-3; Sequence=VSP_052776; Name=4 {ECO:0000269|PubMed:12063394}; Synonyms=NBC4d {ECO:0000269|PubMed:12063394}; IsoId=Q9BY07-4; Sequence=VSP_052775; Name=5; Synonyms=isoform d variant; IsoId=Q9BY07-5; Sequence=VSP_052771, VSP_052773, VSP_052777; Note=No experimental confirmation available. Incomplete sequence. {ECO:0000305}; Name=6 {ECO:0000269|PubMed:12388414}; Synonyms=NBC4f {ECO:0000269|PubMed:12388414}; IsoId=Q9BY07-6; Sequence=VSP_052772, VSP_052774, VSP_052776, VSP_052778, VSP_052780, VSP_052781; Name=7 {ECO:0000269|PubMed:15489334}; IsoId=Q9BY07-7; Sequence=VSP_052770, VSP_052772, VSP_052776; Note=No experimental confirmation available. {ECO:0000305}; Name=8 {ECO:0000269|PubMed:12388414}; Synonyms=NBC4e {ECO:0000269|PubMed:12388414}; IsoId=Q9BY07-8; Sequence=VSP_052779; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17715183}; Multi-pass membrane protein {ECO:0000269|PubMed:17715183}. Note=Expressed in the apical plasma membrane domain of a subset of collecting ducts in the renal medulla. {ECO:0000269|PubMed:17715183}.


uniprotID: Q9Y6M7
geneSymbol: SLC4A7
reactome: R-HSA-425381;
length: 1214
go: ENSG00000033867;
drug: DB01390;
snps: rs3755652
name:
Sodium bicarbonate cotransporter 3 (Electroneutral Na/HCO(3) cotransporter) (Sodium bicarbonate cotransporter 2) (Sodium bicarbonate cotransporter 2b) (Bicarbonate transporter) (Solute carrier family 4 member 7)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasmic vesicle [GO:0031410]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; stereocilium [GO:0032420]; synapse [GO:0045202]; inorganic anion exchanger activity [GO:0005452]; sodium:bicarbonate symporter activity [GO:0008510]; auditory receptor cell development [GO:0060117]; bicarbonate transport [GO:0015701]; regulation of intracellular pH [GO:0051453]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=14;  Name=1; Synonyms=mNBC3, NBCn1-A; IsoId=Q9Y6M7-1; Sequence=Displayed; Name=2; Synonyms=NBCn1-F; IsoId=Q9Y6M7-2; Sequence=VSP_047844; Name=3; IsoId=Q9Y6M7-3; Sequence=VSP_047839, VSP_047842, VSP_047844, VSP_047849; Name=4; IsoId=Q9Y6M7-4; Sequence=VSP_047839, VSP_047842, VSP_047844; Name=5; IsoId=Q9Y6M7-5; Sequence=VSP_047838, VSP_047845, VSP_047848; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:21406692}; Name=6; Synonyms=NBCn1-G; IsoId=Q9Y6M7-6; Sequence=VSP_047840, VSP_047844, VSP_047848; Name=7; Synonyms=NBCn1-D; IsoId=Q9Y6M7-7; Sequence=VSP_047841, VSP_047848; Name=8; Synonyms=NBCn1-C; IsoId=Q9Y6M7-8; Sequence=VSP_047841, VSP_047843, VSP_047848; Name=9; Synonyms=NBCn1-E; IsoId=Q9Y6M7-9; Sequence=VSP_047840, VSP_047844; Name=10; IsoId=Q9Y6M7-10; Sequence=VSP_047840, VSP_047843, VSP_047846, VSP_047847; Name=11; IsoId=Q9Y6M7-11; Sequence=VSP_047840, VSP_047844, VSP_047846, VSP_047847; Name=12; Synonyms=NBCn1-H; IsoId=Q9Y6M7-12; Sequence=VSP_047840, VSP_047843; Name=13; IsoId=Q9Y6M7-13; Sequence=VSP_047841, VSP_047844, VSP_047848; Name=14; IsoId=Q9Y6M7-14; Sequence=VSP_047841, VSP_047844, VSP_047846, VSP_047847; 

location:
SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity). {ECO:0000250}.


uniprotID: Q9NSD5
geneSymbol: SLC6A13
reactome: R-HSA-442660;R-HSA-888593;
name: Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13)
length: 602
go: ENSG00000010379;
drug: DB08848;
snps: rs577294
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; gamma-aminobutyric acid:sodium symporter activity [GO:0005332]; neurotransmitter binding [GO:0042165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NSD5-1; Sequence=Displayed; Name=2; IsoId=Q9NSD5-2; Sequence=VSP_043070; Note=No experimental confirmation available.; Name=3; IsoId=Q9NSD5-3; Sequence=VSP_044887, VSP_044888; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22932902}; Multi-pass membrane protein {ECO:0000269|PubMed:22932902}.


