# annotation

uniprotID: Q6N022
geneSymbol: TENM4
length: 2769
go: ENSG00000149256;
name:
Teneurin-4 (Ten-4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cardiac cell fate specification [GO:0060912]; cardiac muscle cell proliferation [GO:0060038]; central nervous system myelin formation [GO:0032289]; gastrulation with mouth forming second [GO:0001702]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; neuron development [GO:0048666]; positive regulation of gastrulation [GO:2000543]; positive regulation of myelination [GO:0031643]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of myelination [GO:0031641]; self proteolysis [GO:0097264]; signal transduction [GO:0007165]

snps:
rs58537389 rs760852624 rs3812723 rs17137261 rs201191369 rs538881762 rs763485258 rs375681722 rs770111861 rs199687168 rs201995608 rs201769315 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26188006}; Single-pass membrane protein {ECO:0000255}. Cell projection {ECO:0000250|UniProtKB:Q3UHK6}. Nucleus {ECO:0000250|UniProtKB:Q3UHK6}. Cytoplasm {ECO:0000250|UniProtKB:Q3UHK6}.


uniprotID: P24821
geneSymbol: TNC
reactome: R-HSA-216083;R-HSA-3000170;R-HSA-3000178;R-HSA-381426;R-HSA-8957275;
pdb: 1TEN;2RB8;2RBL;
length: 2201
go: ENSG00000041982;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
name:
Tenascin (TN) (Cytotactin) (GMEM) (GP 150-225) (Glioma-associated-extracellular matrix antigen) (Hexabrachion) (JI) (Myotendinous antigen) (Neuronectin) (Tenascin-C) (TN-C)

sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; interstitial matrix [GO:0005614]; membrane [GO:0016020]; perisynaptic extracellular matrix [GO:0098966]; extracellular matrix structural constituent [GO:0005201]; syndecan binding [GO:0045545]; bud outgrowth involved in lung branching [GO:0060447]; cell adhesion [GO:0007155]; cellular protein metabolic process [GO:0044267]; cellular response to prostaglandin D stimulus [GO:0071799]; cellular response to retinoic acid [GO:0071300]; cellular response to vitamin D [GO:0071305]; extracellular matrix organization [GO:0030198]; mesenchymal-epithelial cell signaling involved in prostate gland development [GO:0060739]; negative regulation of cell adhesion [GO:0007162]; neuromuscular junction development [GO:0007528]; odontogenesis of dentin-containing tooth [GO:0042475]; osteoblast differentiation [GO:0001649]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; post-translational protein modification [GO:0043687]; prostate gland epithelium morphogenesis [GO:0060740]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to mechanical stimulus [GO:0009612]; response to wounding [GO:0009611]; wound healing [GO:0042060]

snps:
rs7020958 rs1757095 rs3827816 rs1061494 rs3748169 rs2104772 rs137933052 rs2274750 rs431905513 rs13321 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Isoforms are produced in a tissue- and time-specific manner during development.; Name=1; IsoId=P24821-1; Sequence=Displayed; Name=2; Synonyms=HT-5; IsoId=P24821-2; Sequence=VSP_001412, VSP_001413; Name=3; IsoId=P24821-3; Sequence=VSP_001412; Name=4; Synonyms=HT-33; IsoId=P24821-4; Sequence=VSP_001413; Name=5; IsoId=P24821-5; Sequence=VSP_001414; Name=6; Synonyms=P31; IsoId=P24821-6; Sequence=VSP_001415; 


uniprotID: Q9UQP3
geneSymbol: TNN
reactome: R-HSA-3000178;
name: Tenascin-N (TN-N) (Tenascin-W) (TN-W)
length: 1299
go: ENSG00000120332;
sequence:

opentargets:
CA3 pyramidal cell dendrite [GO:0097442]; cell surface [GO:0009986]; extracellular matrix [GO:0031012]; hippocampal mossy fiber expansion [GO:1990026]; neuronal cell body [GO:0043025]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; axonogenesis [GO:0007409]; cell-matrix adhesion [GO:0007160]; dendrite self-avoidance [GO:0070593]; negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation [GO:1905240]; negative regulation of neuron migration [GO:2001223]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of osteoblast proliferation [GO:0033689]; osteoblast development [GO:0002076]

snps:
rs2072032 rs16847812 rs6664276 rs17374761 rs6696455 rs6694078 rs2285215 rs10798333 rs10158841 rs2072036 

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:19884327}.


uniprotID: Q05066
geneSymbol: SRY
reactome: R-HSA-3769402;
pdb: 1HRY;1HRZ;1J46;1J47;2GZK;
name: Sex-determining region Y protein (Testis-determining factor)
length: 204
go: ENSG00000184895;
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nuclear transcription factor complex [GO:0044798]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; calmodulin binding [GO:0005516]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; transcription factor binding [GO:0008134]; cell differentiation [GO:0030154]; male sex determination [GO:0030238]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; sex differentiation [GO:0007548]

snps:
rs104894971 rs764249635 rs104894957 rs104894969 rs104894968 rs104894959 rs104894972 rs104894974 rs104894964 rs104894956 rs104894966 rs104894973 rs104894976 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11818535}. Cytoplasm {ECO:0000269|PubMed:15297880}. Nucleus {ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192, ECO:0000269|PubMed:28030592}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880). Colocalizes with SOX6 in speckles (PubMed:11818535). Colocalizes with CAML in the nucleus (PubMed:15746192). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). {ECO:0000250|UniProtKB:Q05738, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192}.


uniprotID: P30874
geneSymbol: SSTR2
reactome: R-HSA-375276;R-HSA-418594;
name: Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1)
length: 369
go: ENSG00000180616;
drug: DB06791;DB00104;DB06663;DB04894;
sequence:

opentargets:
cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; PDZ domain binding [GO:0030165]; somatostatin receptor activity [GO:0004994]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cellular response to estradiol stimulus [GO:0071392]; cellular response to glucocorticoid stimulus [GO:0071385]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of cell proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; peristalsis [GO:0030432]; regulation of muscle contraction [GO:0006937]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=A; Synonyms=SSTR2A; IsoId=P30874-1; Sequence=Displayed; Name=B; Synonyms=SSTR2B; IsoId=P30874-2; Sequence=VSP_001922; 

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.


uniprotID: P43307
geneSymbol: SSR1
reactome: R-HSA-1799339;R-HSA-381038;
length: 286
go: ENSG00000124783;
snps: rs10004
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
name:
Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; cotranslational protein targeting to membrane [GO:0006613]; IRE1-mediated unfolded protein response [GO:0036498]; positive regulation of cell proliferation [GO:0008284]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P43307-1; Sequence=Displayed; Name=2; IsoId=P43307-2; Sequence=VSP_013621; Note=No experimental confirmation available.; 


uniprotID: P52823
geneSymbol: STC1
name: Stanniocalcin-1 (STC-1)
length: 247
go: ENSG00000159167;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleus [GO:0005634]; hormone activity [GO:0005179]; bone development [GO:0060348]; cellular calcium ion homeostasis [GO:0006874]; cellular response to cAMP [GO:0071320]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to hypoxia [GO:0071456]; chondrocyte proliferation [GO:0035988]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endothelial cell morphogenesis [GO:0001886]; growth plate cartilage axis specification [GO:0003421]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of renal phosphate excretion [GO:1903403]; ossification [GO:0001503]; positive regulation of calcium ion import [GO:0090280]; regulation of anion transport [GO:0044070]; regulation of cardiac muscle cell contraction [GO:0086004]; response to vitamin D [GO:0033280]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P52823-1; Sequence=Displayed; Name=2; IsoId=P52823-2; Sequence=VSP_057169; Note=No experimental confirmation available.; 


uniprotID: Q96SI9
geneSymbol: STRBP
pdb: 2DMY;
name: Spermatid perinuclear RNA-binding protein
length: 672
go: ENSG00000165209;
sequence:

opentargets:
cytoplasm [GO:0005737]; manchette [GO:0002177]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; mechanosensory behavior [GO:0007638]; multicellular organism development [GO:0007275]; spermatid development [GO:0007286]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96SI9-1; Sequence=Displayed; Name=2; IsoId=Q96SI9-2; Sequence=VSP_022937; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Microtubule-associated that localizes to the manchette in developing spermatids. {ECO:0000250}.


uniprotID: Q9UJZ1
geneSymbol: STOML2
reactome: R-HSA-8949664;
length: 356
go: ENSG00000165283;
snps: rs17856326
name:
Stomatin-like protein 2, mitochondrial (SLP-2) (EPB72-like protein 2) (Paraprotein target 7) (Paratarg-7)

sequence:

opentargets:
cytoskeleton [GO:0005856]; extrinsic component of plasma membrane [GO:0019897]; membrane raft [GO:0045121]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; cardiolipin binding [GO:1901612]; GTPase binding [GO:0051020]; signaling receptor binding [GO:0005102]; CD4-positive, alpha-beta T cell activation [GO:0035710]; cellular calcium ion homeostasis [GO:0006874]; interleukin-2 production [GO:0032623]; lipid localization [GO:0010876]; mitochondrial ATP synthesis coupled proton transport [GO:0042776]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial protein processing [GO:0034982]; mitochondrion organization [GO:0007005]; positive regulation of cardiolipin metabolic process [GO:1900210]; positive regulation of mitochondrial DNA replication [GO:0090297]; positive regulation of mitochondrial membrane potential [GO:0010918]; protein complex oligomerization [GO:0051259]; stress-induced mitochondrial fusion [GO:1990046]; T cell receptor signaling pathway [GO:0050852]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UJZ1-1; Sequence=Displayed; Name=2; IsoId=Q9UJZ1-2; Sequence=VSP_054651; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}; Peripheral membrane protein {ECO:0000269|PubMed:10713127}. Mitochondrion {ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:22623988}. Mitochondrion inner membrane {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18339324, ECO:0000269|PubMed:21746876}; Lipid-anchor {ECO:0000269|PubMed:21746876}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17121834}. Membrane raft {ECO:0000269|PubMed:18641330}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330}. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876). Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:18641330, PubMed:10713127). A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988). {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.


uniprotID: Q9HAC7
geneSymbol: SUGCT
length: 445
go: ENSG00000175600;
opentargets: mitochondrion [GO:0005739]; succinate-hydroxymethylglutarate CoA-transferase activity [GO:0047369]
snps: rs137852860
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23893049}.
name:
Succinate--hydroxymethylglutarate CoA-transferase (EC 2.8.3.13) (Dermal papilla-derived protein 13) (SuccinylCoA:glutarate-CoA transferase)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9HAC7-1; Sequence=Displayed; Name=2; IsoId=Q9HAC7-2; Sequence=VSP_014721, VSP_014722; Note=No experimental confirmation available.; Name=3; IsoId=Q9HAC7-3; Sequence=VSP_014722; Name=4; IsoId=Q9HAC7-4; Sequence=VSP_043291; Note=No experimental confirmation available.; 


uniprotID: O00186
geneSymbol: STXBP3
reactome: R-HSA-114516;R-HSA-1445148;
length: 592
go: ENSG00000116266;
snps: rs2275344 rs1044136 rs1044137
name:
Syntaxin-binding protein 3 (Platelet Sec1 protein) (PSP) (Protein unc-18 homolog 3) (Unc18-3) (Protein unc-18 homolog C) (Unc-18C)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; presynapse [GO:0098793]; specific granule [GO:0042581]; tertiary granule [GO:0070820]; syntaxin binding [GO:0019905]; syntaxin-1 binding [GO:0017075]; brain development [GO:0007420]; cellular response to interferon-gamma [GO:0071346]; insulin secretion [GO:0030073]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of glucose import in response to insulin stimulus [GO:2001274]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; protein heterooligomerization [GO:0051291]; protein to membrane docking [GO:0022615]; response to insulin [GO:0032868]; vesicle docking involved in exocytosis [GO:0006904]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10194441}. Cell membrane {ECO:0000269|PubMed:10194441}. Note=In platelets, predominantly cytosolic. Low amounts membrane-associated.


uniprotID: Q96HP8
geneSymbol: TMEM176A
name: Transmembrane protein 176A (Hepatocellular carcinoma-associated antigen 112)
length: 235
go: ENSG00000002933;
snps: rs741064 rs10378 rs9088
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; negative regulation of dendritic cell differentiation [GO:2001199]


uniprotID: P0DP42
geneSymbol: TMEM225B
name: Transmembrane protein 225B
length: 221
go: ENSG00000244219;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; negative regulation of phosphatase activity [GO:0010923]


uniprotID: Q8NBL3
geneSymbol: TMEM178A
name: Transmembrane protein 178A
length: 297
go: ENSG00000152154;
snps: rs17852679
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; negative regulation of osteoclast differentiation [GO:0045671]; regulation of cytosolic calcium ion concentration [GO:0051480]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NBL3-1; Sequence=Displayed; Name=2; IsoId=Q8NBL3-2; Sequence=VSP_025428, VSP_025429; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9CZ16}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q8WV15
geneSymbol: TMEM255B
name: Transmembrane protein 255B (Protein FAM70B)
length: 326
go: ENSG00000184497;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9Y519
geneSymbol: TMEM184B
name: Transmembrane protein 184B (Putative MAPK-activating protein FM08)
length: 407
go: ENSG00000198792;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9NYW1
geneSymbol: TAS2R9
reactome: R-HSA-418594;R-HSA-420499;
name: Taste receptor type 2 member 9 (T2R9) (Taste receptor family B member 6) (TRB6)
length: 312
go: ENSG00000121381;
snps: rs11054043 rs3741845 rs11054042
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; bitter taste receptor activity [GO:0033038]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; G protein-coupled receptor signaling pathway [GO:0007186]


uniprotID: Q53R12
geneSymbol: TM4SF20
name: Transmembrane 4 L6 family member 20
length: 229
go: ENSG00000168955;
snps: rs7574414
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; negative regulation of proteolysis [GO:0045861]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23810381}; Multi-pass membrane protein {ECO:0000269|PubMed:23810381}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25310401}; Multi-pass membrane protein {ECO:0000269|PubMed:25310401}. Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. {ECO:0000269|PubMed:27499293}.


uniprotID: Q9UQF0
geneSymbol: ERVW-1
pdb: 5HA6;
length: 538
go: ENSG00000242950;
snps: rs142852059 rs55903518 rs10266695 rs141340741
name:
Syncytin-1 (Endogenous retrovirus group W member 1) (Env-W) (Envelope polyprotein gPr73) (Enverin) (HERV-7q Envelope protein) (HERV-W envelope protein) (HERV-W_7q21.2 provirus ancestral Env polyprotein) (Syncytin) [Cleaved into: Surface protein (SU) (gp50); Transmembrane protein (TM) (gp24)]

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; anatomical structure morphogenesis [GO:0009653]; syncytium formation [GO:0006949]; syncytium formation by plasma membrane fusion [GO:0000768]

location:
SUBCELLULAR LOCATION: Surface protein: Cell membrane {ECO:0000305|PubMed:15827173}; Peripheral membrane protein {ECO:0000305|PubMed:15827173}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000305|PubMed:15827173}.; SUBCELLULAR LOCATION: Transmembrane protein: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Syncytin-1: Virion {ECO:0000250}.


uniprotID: Q8IZJ6
geneSymbol: TDH
reactome: R-HSA-8849175;
length: 230
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8MIR0}.
name:
Inactive L-threonine 3-dehydrogenase, mitochondrial (Short chain dehydrogenase/reductase family 14E member 1 pseudogene)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; catalytic activity [GO:0003824]; coenzyme binding [GO:0050662]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000269|PubMed:12361482}; IsoId=Q8IZJ6-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:14702039}; IsoId=Q8IZJ6-2; Sequence=VSP_052507; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000269|PubMed:12361482}; IsoId=Q8IZJ6-3; Sequence=VSP_052507, VSP_052508, VSP_052509; 


uniprotID: Q9H147
geneSymbol: DNTTIP1
pdb: 2MWI;4D6K;
length: 329
go: ENSG00000101457;
snps: rs408911
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11473582, ECO:0000269|PubMed:16371131}.
name:
Deoxynucleotidyltransferase terminal-interacting protein 1 (Terminal deoxynucleotidyltransferase-interacting factor 1) (TdIF1) (TdT-interacting factor 1)

sequence:

opentargets:
histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; nucleosome binding [GO:0031491]; protein homodimerization activity [GO:0042803]


uniprotID: Q5QJE6
geneSymbol: DNTTIP2
length: 756
go: ENSG00000067334;
opentargets: nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]
snps: rs3747965 rs3179879 rs35650636 rs41292661 rs12748154
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12786946, ECO:0000269|PubMed:15047147}.
name:
Deoxynucleotidyltransferase terminal-interacting protein 2 (Estrogen receptor-binding protein) (LPTS-interacting protein 2) (LPTS-RP2) (Terminal deoxynucleotidyltransferase-interacting factor 2) (TdIF2) (TdT-interacting factor 2)

sequence:


uniprotID: Q5VZ19
geneSymbol: TDRD10
name: Tudor domain-containing protein 10
length: 366
go: ENSG00000163239;
opentargets: RNA binding [GO:0003723]
snps: rs12750774 rs3811448
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5VZ19-1; Sequence=Displayed; Name=2; IsoId=Q5VZ19-2; Sequence=VSP_022216; 


uniprotID: Q587J7
geneSymbol: TDRD12
reactome: R-HSA-5601884;
length: 1177
go: ENSG00000173809;
name:
Putative ATP-dependent RNA helicase TDRD12 (EC 3.6.4.13) (ES cell-associated transcript 8 protein) (Tudor domain-containing protein 12)

sequence:

opentargets:
PET complex [GO:1990923]; ATP binding [GO:0005524]; helicase activity [GO:0004386]; nucleic acid binding [GO:0003676]; cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiotic nuclear division [GO:0007140]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q587J7-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q587J7-2; Sequence=VSP_029675, VSP_029676; 


uniprotID: B5MCY1
geneSymbol: TDRD15
name: Tudor domain-containing protein 15
length: 1934
go: ENSG00000218819;
sequence:


uniprotID: Q9BXT4
geneSymbol: TDRD1
reactome: R-HSA-5601884;
pdb: 5M9N;
name: Tudor domain-containing protein 1 (Cancer/testis antigen 41.1) (CT41.1)
length: 1180
go: ENSG00000095627;
snps: rs7914059 rs34112549
sequence:

opentargets:
chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; P granule [GO:0043186]; pi-body [GO:0071546]; metal ion binding [GO:0046872]; DNA methylation involved in gamete generation [GO:0043046]; gene silencing by RNA [GO:0031047]; germ cell development [GO:0007281]; meiotic cell cycle [GO:0051321]; multicellular organism development [GO:0007275]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9BXT4-1; Sequence=Displayed; Name=2; IsoId=Q9BXT4-2; Sequence=VSP_035481, VSP_035482; Name=3; IsoId=Q9BXT4-3; Sequence=VSP_036670; Note=No experimental confirmation available.; Name=4; IsoId=Q9BXT4-4; Sequence=VSP_036667, VSP_036668, VSP_035481, VSP_036669; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}.


uniprotID: Q9H7E2
geneSymbol: TDRD3
pdb: 1WJI;2LTO;3PMT;3PNW;3S6W;5GVD;5GVE;5YJ8;
name: Tudor domain-containing protein 3
length: 651
go: ENSG00000083544;
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; chromatin organization [GO:0006325]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H7E2-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=Q9H7E2-2; Sequence=VSP_037053; Name=3; IsoId=Q9H7E2-3; Sequence=VSP_037052; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18632687}. Nucleus {ECO:0000269|PubMed:21172665}. Note=Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules. {ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:18664458}.


uniprotID: Q8NAT2
geneSymbol: TDRD5
pdb: 3S93;
name: Tudor domain-containing protein 5
length: 981
go: ENSG00000162782;
snps: rs12066948 rs12069976 rs6704505 rs35448215
sequence:

opentargets:
chromatoid body [GO:0033391]; pi-body [GO:0071546]; DNA methylation involved in gamete generation [GO:0043046]; P granule organization [GO:0030719]; spermatid development [GO:0007286]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=3; IsoId=Q8NAT2-3; Sequence=Displayed; Name=1; IsoId=Q8NAT2-1; Sequence=VSP_023968; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. {ECO:0000250}.


uniprotID: O60522
geneSymbol: TDRD6
reactome: R-HSA-5601884;
name: Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2)
length: 2096
go: ENSG00000180113;
snps: rs7750596 rs3799277 rs9463234 rs9381472
sequence:

opentargets:
chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60522-1; Sequence=Displayed; Name=2; IsoId=O60522-2; Sequence=VSP_044801; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61407}. Note=Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids. Colocalizes in CB with DDX4, PIWIL1, PIWIL2, TDRD1 and TDRD7 (By similarity). {ECO:0000250|UniProtKB:P61407}.


uniprotID: Q8NHU6
geneSymbol: TDRD7
pdb: 3RCO;
length: 1098
go: ENSG00000196116;
snps: rs2045732 rs17852595
name:
Tudor domain-containing protein 7 (PCTAIRE2-binding protein) (Tudor repeat associator with PCTAIRE-2) (Trap)

sequence:

opentargets:
chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; ribonucleoprotein granule [GO:0035770]; mRNA binding [GO:0003729]; protein N-terminus binding [GO:0047485]; lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; posttranscriptional regulation of gene expression [GO:0010608]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NHU6-1; Sequence=Displayed; Name=2; IsoId=Q8NHU6-2; Sequence=VSP_041315; Note=No experimental confirmation available.; Name=3; IsoId=Q8NHU6-3; Sequence=VSP_041314, VSP_041316; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21436445}. Note=Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity). {ECO:0000250}.


uniprotID: Q8NDG6
geneSymbol: TDRD9
reactome: R-HSA-5601884;
name: ATP-dependent RNA helicase TDRD9 (EC 3.6.4.13) (Tudor domain-containing protein 9)
length: 1382
go: ENSG00000156414;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; piP-body [GO:0071547]; ATP binding [GO:0005524]; ATP-dependent 3'-5' RNA helicase activity [GO:0034459]; ATPase activity [GO:0016887]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiosis I [GO:0007141]; male meiotic nuclear division [GO:0007140]; multicellular organism development [GO:0007275]; negative regulation of transposition [GO:0010529]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NDG6-1; Sequence=Displayed; Name=2; IsoId=Q8NDG6-2; Sequence=VSP_033552; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28536242}. Nucleus {ECO:0000250|UniProtKB:Q14BI7}. Note=Component of the nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. {ECO:0000250|UniProtKB:Q14BI7}.


uniprotID: Q3Y452
geneSymbol: TDRG1
name: Testis development-related protein 1
length: 100
opentargets: cytoplasm [GO:0005737]; multicellular organism development [GO:0007275]
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22123530}.
sequence:
MKRREAVCAHRHFLGTGKPPHPLGRSIPVEPCPGLPAFAEVDLLSLLVPIKISSTPPSGSRLDPQIASSAFPGLGSLGGQDSSGSLVQRASCELESPYEL


uniprotID: Q9Y2W6
geneSymbol: TDRKH
reactome: R-HSA-5601884;
pdb: 2DIQ;3FDR;5J39;6B57;
name: Tudor and KH domain-containing protein (Tudor domain-containing protein 2)
length: 561
go: ENSG00000182134;
snps: rs17853082
sequence:

opentargets:
mitochondrion [GO:0005739]; pi-body [GO:0071546]; piP-body [GO:0071547]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; DNA methylation involved in gamete generation [GO:0043046]; fertilization [GO:0009566]; gene silencing by RNA [GO:0031047]; male meiotic nuclear division [GO:0007140]; piRNA metabolic process [GO:0034587]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2W6-2; Sequence=Displayed; Name=2; IsoId=Q9Y2W6-3; Sequence=VSP_040981; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80VL1}. Mitochondrion {ECO:0000250|UniProtKB:Q80VL1}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline. {ECO:0000250|UniProtKB:Q80VL1}.


uniprotID: Q86YL5
geneSymbol: TDRP
name: Testis development-related protein (Protein INM01)
length: 185
go: ENSG00000180190;
sequence:
MWKLGRGRVLLDEPPEEEDGLRGGPPPAAAAAAQAQVQGASFRGWKEVTSLFNKDDEQHLLERCKSPKSKGTNLRLKEELKAEKKSGFWDNLVLKQNIQSKKPDEIEGWEPPKLALEDISADPEDTVGGHPSWSGWEDDAKGSTKYTSLASSANSSRWSLRAAGRLVSIRRQSKGHLTDSPEEAE

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=TDRP1; IsoId=Q86YL5-1; Sequence=Displayed; Name=2; Synonyms=TDRP2; IsoId=Q86YL5-2; Sequence=VSP_045212; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20170638, ECO:0000269|PubMed:27069551}. Cytoplasm {ECO:0000269|PubMed:20170638, ECO:0000269|PubMed:27069551}. Note=Mainly nuclear. Also detected in cytoplasm near the midpiece of the flagellum. {ECO:0000269|PubMed:27069551}.


uniprotID: P04053
geneSymbol: DNTT
pdb: 2COE;
length: 509
go: ENSG00000107447;
snps: rs6584066
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16371131}.
name:
DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltransferase) (Terminal transferase)

sequence:

opentargets:
cytosol [GO:0005829]; euchromatin [GO:0000791]; nuclear chromatin [GO:0000790]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA nucleotidylexotransferase activity [GO:0003912]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; DNA metabolic process [GO:0006259]; DNA modification [GO:0006304]; response to ATP [GO:0033198]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P04053-1; Sequence=Displayed; Name=2; IsoId=P04053-2; Sequence=VSP_038397; 


uniprotID: Q96NR7
geneSymbol: WWC2-AS2
name: Putative uncharacterized protein WWC2-AS2 (WWC2 antisense RNA 2) (WWC2 antisense gene protein 2)
length: 200
sequence:


uniprotID: Q92558
geneSymbol: WASF1
reactome: R-HSA-2029482;R-HSA-4420097;R-HSA-5663213;
pdb: 3P8C;4N78;
length: 559
go: ENSG00000112290;
name:
Wiskott-Aldrich syndrome protein family member 1 (WASP family protein member 1) (Protein WAVE-1) (Verprolin homology domain-containing protein 1)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoskeleton [GO:0005856]; dendrite cytoplasm [GO:0032839]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; mitochondrial outer membrane [GO:0005741]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; SCAR complex [GO:0031209]; actin binding [GO:0003779]; protein kinase A binding [GO:0051018]; protein-containing complex binding [GO:0044877]; actin filament polymerization [GO:0030041]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; dendritic transport of mitochondrion [GO:0098939]; lamellipodium morphogenesis [GO:0072673]; modification of postsynaptic actin cytoskeleton [GO:0098885]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; protein-containing complex assembly [GO:0065003]; Rac protein signal transduction [GO:0016601]; receptor-mediated endocytosis [GO:0006898]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9889097}. Cell junction, synapse {ECO:0000250|UniProtKB:Q5BJU7}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9889097}.


uniprotID: Q8TCV5
geneSymbol: WFDC5
length: 224
go: ENSG00000175121;
opentargets: extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]
snps: rs17422688
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
WAP four-disulfide core domain protein 5 (Putative protease inhibitor WAP1) (p53-responsive gene 5 protein)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TCV5-1; Sequence=Displayed; Note=Gene prediction confirmed by EST data.; Name=2; IsoId=Q8TCV5-2; Sequence=VSP_006756; 


uniprotID: Q6PP77
geneSymbol: XKRX
name: XK-related protein 2 (Membrane protein XPLAC) (X Kell blood group-related, X-linked)
length: 449
go: ENSG00000182489;
opentargets: integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6PP77-1; Sequence=Displayed; Name=2; IsoId=Q6PP77-2; Sequence=VSP_037520; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037}; Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.


uniprotID: Q9NQA3
geneSymbol: WASH6P
name: WAS protein family homolog 6 (Protein FAM39A)
length: 447
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endosomal transport [GO:0016197]; retrograde transport, endosome to Golgi [GO:0042147]

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250|UniProtKB:A8K0Z3}.


uniprotID: O00401
geneSymbol: WASL
reactome: R-HSA-2029482;R-HSA-203641;R-HSA-373753;R-HSA-3928662;R-HSA-418885;R-HSA-5663213;R-HSA-8856828;
pdb: 2FF3;2LNH;2VCP;4CC2;4CC7;
name: Neural Wiskott-Aldrich syndrome protein (N-WASP)
length: 505
go: ENSG00000106299;
sequence:

opentargets:
actin cap [GO:0030478]; actin cortical patch [GO:0030479]; actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; GTPase regulator activity [GO:0030695]; actin cortical patch assembly [GO:0000147]; actin cortical patch localization [GO:0051666]; actin filament polymerization [GO:0030041]; actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; cell division [GO:0051301]; cellular protein-containing complex localization [GO:0034629]; dendritic spine morphogenesis [GO:0060997]; endocytosis [GO:0006897]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; membrane organization [GO:0061024]; negative regulation of lymphocyte migration [GO:2000402]; negative regulation of membrane tubulation [GO:1903526]; positive regulation of actin nucleation [GO:0051127]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of protein localization [GO:0032880]; response to bacterium [GO:0009617]; spindle localization [GO:0051653]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9422512}. Nucleus {ECO:0000269|PubMed:16767080}. Cytoplasm {ECO:0000250|UniProtKB:Q91YD9}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q91YD9}.


uniprotID: Q6ZWC4
name: Putative uncharacterized protein LOC100128429
length: 215
sequence:


uniprotID: Q9Y4E6
geneSymbol: WDR7
name: WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG)
length: 1490
go: ENSG00000091157;
opentargets: synaptic vesicle [GO:0008021]; hematopoietic progenitor cell differentiation [GO:0002244]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y4E6-1; Sequence=Displayed; Name=2; IsoId=Q9Y4E6-2; Sequence=VSP_015274; 


uniprotID: O96014
geneSymbol: WNT11
reactome: R-HSA-3238698;R-HSA-373080;R-HSA-4086398;R-HSA-4086400;
name: Protein Wnt-11
length: 354
go: ENSG00000085741;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; GTPase activator activity [GO:0005096]; protein kinase activator activity [GO:0030295]; transcription regulatory region DNA binding [GO:0044212]; adrenal gland development [GO:0030325]; artery morphogenesis [GO:0048844]; bicellular tight junction assembly [GO:0070830]; bone mineralization [GO:0030282]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to mechanical stimulus [GO:0071260]; cellular response to retinoic acid [GO:0071300]; cloacal septation [GO:0060197]; convergent extension involved in axis elongation [GO:0060028]; embryonic skeletal system development [GO:0048706]; epithelial to mesenchymal transition [GO:0001837]; lung-associated mesenchyme development [GO:0060484]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; mesonephric duct development [GO:0072177]; negative regulation of apoptotic process [GO:0043066]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell death [GO:0060548]; negative regulation of cell growth [GO:0030308]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of transcription, DNA-templated [GO:0045892]; neuroendocrine cell differentiation [GO:0061101]; neuron differentiation [GO:0030182]; notochord morphogenesis [GO:0048570]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transforming growth factor beta2 production [GO:0032915]; protein localization to cell surface [GO:0034394]; protein phosphorylation [GO:0006468]; response to nutrient levels [GO:0031667]; secondary palate development [GO:0062009]; somite development [GO:0061053]; ureteric bud morphogenesis [GO:0060675]; ventricular septum morphogenesis [GO:0060412]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]


uniprotID: Q9Y4P8
geneSymbol: WIPI2
reactome: R-HSA-1632852;
name: WD repeat domain phosphoinositide-interacting protein 2 (WIPI-2) (WIPI49-like protein 2)
length: 454
go: ENSG00000157954;
sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleoplasm [GO:0005654]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; protein-containing complex [GO:0032991]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-5-phosphate binding [GO:0010314]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; macroautophagy [GO:0016236]; protein lipidation [GO:0006497]; protein lipidation involved in autophagosome assembly [GO:0061739]; protein localization to phagophore assembly site [GO:0034497]; xenophagy [GO:0098792]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=WIPI-2 alpha, WIPI2a; IsoId=Q9Y4P8-1; Sequence=Displayed; Name=2; Synonyms=WIPI-2 beta, WIPI2d; IsoId=Q9Y4P8-2; Sequence=VSP_016972, VSP_016974; Name=3; Synonyms=WIPI2e; IsoId=Q9Y4P8-3; Sequence=VSP_016970, VSP_016973, VSP_016974; Note=No experimental confirmation available.; Name=4; Synonyms=WIPI2b; IsoId=Q9Y4P8-4; Sequence=VSP_016972; Name=5; Synonyms=WIPI-2 delta; IsoId=Q9Y4P8-5; Sequence=VSP_016971, VSP_016974; Name=6; Synonyms=WIPI2c; IsoId=Q9Y4P8-6; Sequence=VSP_016974; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507, ECO:0000269|PubMed:23916833}; Peripheral membrane protein {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}; Cytoplasmic side {ECO:0000269|PubMed:20505359, ECO:0000269|PubMed:21564513, ECO:0000269|PubMed:22456507}. Note=Localizes to omegasomes membranes which are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. {ECO:0000269|PubMed:24954904}.


uniprotID: Q5GH77
geneSymbol: XKR3
name: XK-related protein 3 (X Kell blood group-related 3) (XTES)
length: 459
go: ENSG00000172967;
opentargets: integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
snps: rs5748648 rs9605146 rs5748623 rs5748622
sequence:

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037}; Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.


uniprotID: Q6UX68
geneSymbol: XKR5
name: XK-related protein 5
length: 686
go: ENSG00000275591;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=5a {ECO:0000303|Ref.1}; IsoId=Q6UX68-1; Sequence=Displayed; Name=2; IsoId=Q6UX68-3; Sequence=VSP_059371, VSP_059372; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}; 


uniprotID: A4D1P6
geneSymbol: WDR91
name: WD repeat-containing protein 91
length: 747
go: ENSG00000105875;
snps: rs292592
sequence:

opentargets:
cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extrinsic component of endosome membrane [GO:0031313]; late endosome membrane [GO:0031902]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; early endosome to late endosome transport [GO:0045022]; regulation of cellular protein catabolic process [GO:1903362]; regulation of phosphatidylinositol 3-kinase activity [GO:0043551]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A4D1P6-1; Sequence=Displayed; Name=2; IsoId=A4D1P6-2; Sequence=VSP_027060, VSP_027061; Note=No experimental confirmation available.; Name=3; IsoId=A4D1P6-3; Sequence=VSP_027058, VSP_027059; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:26783301}; Peripheral membrane protein {ECO:0000269|PubMed:26783301}. Late endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:28404643}.


uniprotID: Q6ZVQ6
name: Putative uncharacterized protein FLJ42213
length: 151
sequence:
MHAGKRSPLTQSISCVCLPELGALWEIESARVNLRVSGREASREMESSPRPHRIAGVKRFLKHAGKWSLRWFLSPRWILQFRRWARKWSRFTRSSFQVRWAAVPAGKCSQHQGLSAVATASPGVFWEMEFDVSSPLTEGAGSPMSSKHAGE


uniprotID: Q9H1J7
geneSymbol: WNT5B
reactome: R-HSA-3238698;R-HSA-4086400;
name: Protein Wnt-5b
length: 359
go: ENSG00000111186;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; signaling receptor binding [GO:0005102]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fat cell differentiation [GO:0045444]; lens fiber cell development [GO:0070307]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; neuron differentiation [GO:0030182]; positive regulation of cell migration [GO:0030335]; positive regulation of fat cell differentiation [GO:0045600]; Wnt signaling pathway [GO:0016055]; wound healing [GO:0042060]


uniprotID: Q6ICG8
geneSymbol: WBP2NL
name: Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like)
length: 309
go: ENSG00000183066;
snps: rs17002790 rs133335 rs17002802 rs2301521
sequence:

opentargets:
nucleus [GO:0005634]; perinuclear theca [GO:0033011]; sperm flagellum [GO:0036126]; sperm head [GO:0061827]; chromatin DNA binding [GO:0031490]; transcription coactivator activity [GO:0003713]; WW domain binding [GO:0050699]; egg activation [GO:0007343]; female pronucleus assembly [GO:0035038]; male pronucleus assembly [GO:0035039]; meiotic cell cycle [GO:0051321]


uniprotID: O43592
geneSymbol: XPOT
reactome: R-HSA-6784531;
name: Exportin-T (Exportin(tRNA)) (tRNA exportin)
length: 962
go: ENSG00000184575;
snps: rs17851795 rs1051396
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; Ran GTPase binding [GO:0008536]; tRNA binding [GO:0000049]; tRNA export from nucleus [GO:0006409]; tRNA re-export from nucleus [GO:0071528]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear, once bound to tRNA and Ran the complex translocates to the cytoplasm. Shuttles between the nucleus and the cytoplasm.


uniprotID: Q9HAD4
geneSymbol: WDR41
name: WD repeat-containing protein 41
length: 459
go: ENSG00000164253;
snps: rs389319 rs17751013 rs33204
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27193190}.
sequence:

opentargets:
cytoplasm [GO:0005737]; guanyl-nucleotide exchange factor complex [GO:0032045]; lysosomal membrane [GO:0005765]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HAD4-1; Sequence=Displayed; Name=2; IsoId=Q9HAD4-2; Sequence=VSP_054014; Note=No experimental confirmation available.; 


uniprotID: P55808
geneSymbol: XG
name: Glycoprotein Xg (Protein PBDX)
length: 180
go: ENSG00000124343;
opentargets: integral component of plasma membrane [GO:0005887]
snps: rs5939319
sequence:
MESWWGLPCLAFLCFLMHARGQRDFDLADALDDPEPTKKPNSDIYPKPKPPYYPQPENPDSGGNIYPRPKPRPQPQPGNSGNSGGYFNDVDRDDGRYPPRPRPRPPAGGGGGGYSSYGNSDNTHGGDHHSTYGNPEGNMVAKIVSPIVSVVVVTLLGAAASYFKLNNRRNCFRTHEPENV

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P55808-1; Sequence=Displayed; Name=2; IsoId=P55808-2; Sequence=VSP_037319; Note=No experimental confirmation available.; Name=3; IsoId=P55808-3; Sequence=VSP_037320; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7533029}; Single-pass type I membrane protein {ECO:0000269|PubMed:7533029}.


uniprotID: A6NE52
geneSymbol: WDR97
name: WD repeat-containing protein 97
length: 1622
go: ENSG00000179698;
snps: rs4977196 rs34324679 rs13250446
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NE52-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=A6NE52-2; Sequence=VSP_033425, VSP_033426; Note=No experimental confirmation available.; 


uniprotID: Q9H1Z4
geneSymbol: WDR13
name: WD repeat-containing protein 13
length: 485
snps: rs235842
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12659815}.
sequence:

opentargets:
microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; promoter-specific chromatin binding [GO:1990841]; negative regulation of type B pancreatic cell proliferation [GO:1904691]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H1Z4-1; Sequence=Displayed; Name=2; IsoId=Q9H1Z4-2; Sequence=VSP_054010; 


uniprotID: O15213
geneSymbol: WDR46
reactome: R-HSA-6790901;R-HSA-6791226;
name: WD repeat-containing protein 46 (WD repeat-containing protein BING4)
length: 610
go: ENSG00000227057;
snps: rs3130257 rs34704405 rs14398
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:23848194}.
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; rRNA processing [GO:0006364]


uniprotID: Q96MX6
geneSymbol: WDR92
pdb: 3I2N;
name: WD repeat-containing protein 92 (WD repeat-containing protein Monad)
length: 357
go: ENSG00000243667;
opentargets: ubiquitin binding [GO:0043130]; apoptotic process [GO:0006915]
snps: rs13009282
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96MX6-1; Sequence=Displayed; Name=2; IsoId=Q96MX6-2; Sequence=VSP_045123; 


uniprotID: P46094
geneSymbol: XCR1
reactome: R-HSA-380108;R-HSA-416476;
length: 333
go: ENSG00000173578;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Chemokine XC receptor 1 (G-protein coupled receptor 5) (Lymphotactin receptor) (XC chemokine receptor 1)

sequence:

opentargets:
external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; C-C chemokine binding [GO:0019957]; C-C chemokine receptor activity [GO:0016493]; chemokine binding [GO:0019956]; chemokine receptor activity [GO:0004950]; calcium-mediated signaling [GO:0019722]; cell chemotaxis [GO:0060326]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; immune response [GO:0006955]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]


uniprotID: Q9UBV4
geneSymbol: WNT16
reactome: R-HSA-3238698;R-HSA-373080;
name: Protein Wnt-16
length: 365
go: ENSG00000002745;
snps: rs2908004 rs2707466
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; bone remodeling [GO:0046849]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; keratinocyte differentiation [GO:0030216]; keratinocyte proliferation [GO:0043616]; negative regulation of cell death [GO:0060548]; neuron differentiation [GO:0030182]; optic cup formation involved in camera-type eye development [GO:0003408]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of gene expression [GO:0010628]; positive regulation of JNK cascade [GO:0046330]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; replicative senescence [GO:0090399]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Wnt-16b; IsoId=Q9UBV4-1; Sequence=Displayed; Name=Wnt-16a; IsoId=Q9UBV4-2; Sequence=VSP_006797; 


uniprotID: Q64LD2
geneSymbol: WDR25
name: WD repeat-containing protein 25
length: 544
go: ENSG00000176473;
snps: rs2273801 rs2181170 rs34331240 rs2273800
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q64LD2-1; Sequence=Displayed; Name=2; IsoId=Q64LD2-2; Sequence=VSP_021331, VSP_021332; 


uniprotID: Q9H1J5
geneSymbol: WNT8A
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-4641262;
name: Protein Wnt-8a (Protein Wnt-8d)
length: 351
go: ENSG00000061492;
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:0061317]; canonical Wnt signaling pathway involved in neural crest cell differentiation [GO:0044335]; cell fate commitment [GO:0045165]; neural crest cell fate commitment [GO:0014034]; neuron differentiation [GO:0030182]; regulation of transcription involved in anterior/posterior axis specification [GO:0044324]; response to retinoic acid [GO:0032526]; secondary palate development [GO:0062009]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H1J5-1; Sequence=Displayed; Name=2; IsoId=Q9H1J5-2; Sequence=VSP_038706; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.


uniprotID: O95388
geneSymbol: WISP1
length: 367
go: ENSG00000104415;
snps: rs35513885
location: SUBCELLULAR LOCATION: Secreted.
name:
WNT1-inducible-signaling pathway protein 1 (WISP-1) (CCN family member 4) (Wnt-1-induced secreted protein)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of cell death [GO:0060548]; regulation of cell growth [GO:0001558]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=O95388-1; Sequence=Displayed; Name=2; Synonyms=WISP1v; IsoId=O95388-2; Sequence=VSP_008008, VSP_008009; Name=3; IsoId=O95388-3; Sequence=VSP_042010; Name=4; IsoId=O95388-4; Sequence=VSP_045958, VSP_045959; Name=5; IsoId=O95388-5; Sequence=VSP_047706, VSP_047707; 


uniprotID: Q6P4I2
geneSymbol: WDR73
name: WD repeat-containing protein 73
length: 378
go: ENSG00000177082;
snps: rs11073619
sequence:

opentargets:
cleavage furrow [GO:0032154]; cytosol [GO:0005829]; spindle pole [GO:0000922]; cytoplasmic microtubule organization [GO:0031122]; negative regulation of apoptotic process [GO:0043066]; nucleus organization [GO:0006997]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:25466283}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:25466283}. Cleavage furrow {ECO:0000269|PubMed:25466283}. Note=During interphase, located in the cytosol. During mitosis, accumulates at the spindle poles and microtubule asters and later in the cleavage furrow. {ECO:0000269|PubMed:25466283}.


uniprotID: Q9UPY5
geneSymbol: SLC7A11
reactome: R-HSA-210991;R-HSA-352230;
length: 501
go: ENSG00000151012;
drug: DB06151;DB00138;DB00142;DB00740;DB01098;DB00795;DB04348;DB08834;
name:
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)

sequence:

opentargets:
astrocyte projection [GO:0097449]; brush border membrane [GO:0031526]; cell surface [GO:0009986]; cytoskeleton [GO:0005856]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; cystine:glutamate antiporter activity [GO:0015327]; L-amino acid transmembrane transporter activity [GO:0015179]; adult behavior [GO:0030534]; cellular response to oxidative stress [GO:0034599]; dipeptide import across plasma membrane [GO:0140206]; glutamate homeostasis [GO:0090461]; glutathione metabolic process [GO:0006749]; glutathione transmembrane transport [GO:0034775]; L-glutamate import across plasma membrane [GO:0098712]; lens fiber cell differentiation [GO:0070306]; leukocyte migration [GO:0050900]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; platelet aggregation [GO:0070527]; regulation of AMPA glutamate receptor clustering [GO:1904717]; regulation of cell proliferation [GO:0042127]; regulation of cysteine metabolic process [GO:1901494]; regulation of glutamate metabolic process [GO:2000211]; regulation of glutathione biosynthetic process [GO:1903786]; regulation of melanin biosynthetic process [GO:0048021]; regulation of neutrophil apoptotic process [GO:0033029]; regulation of protein transport [GO:0051223]; response to nicotine [GO:0035094]; response to organic cyclic compound [GO:0014070]; response to redox state [GO:0051775]; response to toxic substance [GO:0009636]; striatum development [GO:0021756]; ventricular system development [GO:0021591]; visual learning [GO:0008542]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15151999}; Multi-pass membrane protein {ECO:0000269|PubMed:15151999}.


uniprotID: Q6VEQ5
geneSymbol: WASH2P
name: WAS protein family homolog 2 (CXYorf1-like protein on chromosome 2) (Protein FAM39B)
length: 465
sequence:

opentargets:
autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endosomal transport [GO:0016197]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Late endosome {ECO:0000250|UniProtKB:A8K0Z3}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. {ECO:0000250|UniProtKB:A8K0Z3}.


uniprotID: O14980
geneSymbol: XPO1
pdb: 1W9C;2L1L;3GB8;4BSM;4BSN;5DIS;
name: Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog)
length: 1071
go: ENSG00000082898;
reactome:
R-HSA-141444;R-HSA-165054;R-HSA-168333;R-HSA-2173788;R-HSA-2467813;R-HSA-2500257;R-HSA-3769402;R-HSA-450520;R-HSA-5663220;R-HSA-5687128;R-HSA-68877;R-HSA-69273;

sequence:

opentargets:
annulate lamellae [GO:0005642]; Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; host cell [GO:0043657]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; nuclear export signal receptor activity [GO:0005049]; protein domain specific binding [GO:0019904]; protein transporter activity [GO:0008565]; Ran GTPase binding [GO:0008536]; RNA binding [GO:0003723]; transporter activity [GO:0005215]; intracellular transport of virus [GO:0075733]; mRNA transport [GO:0051028]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nucleocytoplasmic transport [GO:0006913]; protein export from nucleus [GO:0006611]; protein localization to nucleus [GO:0034504]; regulation of centrosome duplication [GO:0010824]; regulation of mRNA stability [GO:0043488]; regulation of protein catabolic process [GO:0042176]; regulation of protein export from nucleus [GO:0046825]; response to drug [GO:0042493]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; ribosomal subunit export from nucleus [GO:0000054]; ribosome biogenesis [GO:0042254]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm. Nucleus, Cajal body. Nucleus, nucleolus. Note=Located in the nucleoplasm, Cajal bodies and nucleoli. Shuttles between the nucleus/nucleolus and the cytoplasm.


uniprotID: Q9NNW5
geneSymbol: WDR6
name: WD repeat-containing protein 6
length: 1121
go: ENSG00000178252;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; cell cycle arrest [GO:0007050]; negative regulation of autophagy [GO:0010507]; negative regulation of cell proliferation [GO:0008285]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17216128}. Note=Colocalizes in the cytoplasm with STK11/LKB1.


uniprotID: P04275
geneSymbol: VWF
name: von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)]
length: 2813
go: ENSG00000110799;
drug: DB00025;DB05202;
reactome:
R-HSA-114608;R-HSA-140837;R-HSA-216083;R-HSA-354192;R-HSA-354194;R-HSA-372708;R-HSA-430116;R-HSA-5674135;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802955;R-HSA-75892;R-HSA-76009;

pdb:
1AO3;1ATZ;1AUQ;1FE8;1FNS;1IJB;1IJK;1M10;1OAK;1SQ0;1U0N;1UEX;2ADF;2MHP;2MHQ;3GXB;3HXO;3HXQ;3PPV;3PPW;3PPX;3PPY;3ZQK;4C29;4C2A;4C2B;4DMU;4NT5;5BV8;

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; Weibel-Palade body [GO:0033093]; chaperone binding [GO:0051087]; collagen binding [GO:0005518]; extracellular matrix structural constituent [GO:0005201]; identical protein binding [GO:0042802]; immunoglobulin binding [GO:0019865]; integrin binding [GO:0005178]; protease binding [GO:0002020]; protein homodimerization activity [GO:0042803]; protein N-terminus binding [GO:0047485]; blood coagulation [GO:0007596]; blood coagulation, intrinsic pathway [GO:0007597]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; extracellular matrix organization [GO:0030198]; hemostasis [GO:0007599]; platelet activation [GO:0030168]; platelet degranulation [GO:0002576]; protein homooligomerization [GO:0051260]; response to wounding [GO:0009611]

snps:
rs61753997 rs1800387 rs62643626 rs1800377 rs1800378 rs61754010 rs61754011 rs2228317 rs61748476 rs1063856 rs61748477 rs121964894 rs216321 rs41276738 rs11064002 rs61748497 rs61748511 rs61749370 rs61749371 rs63524161 rs61749372 rs61749384 rs61749387 rs61749392 rs61749393 rs61749397 rs61749398 rs61749403 rs61750071 rs61750072 rs216311 rs216312 rs61750088 rs61750089 rs1800383 rs61750101 rs267607342 rs1800385 rs1800386 rs61750117 rs61750577 rs61750117 rs61750579 rs61750580 rs61750581 rs61750584 rs61750588 rs61750590 rs61750596 rs61750615 rs34230288 rs2229446 rs61750630 rs61751298 rs7962217 rs61751305 rs61751310 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P04275-1; Sequence=Displayed; Name=2; IsoId=P04275-2; Sequence=VSP_056527, VSP_056528, VSP_056529; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10961880}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10961880}. Note=Localized to storage granules.


uniprotID: Q9Y3S1
geneSymbol: WNK2
reactome: R-HSA-2672351;
pdb: 6ELM;6FBK;
length: 2297
go: ENSG00000165238;
snps: rs10761203 rs10114908
name:
Serine/threonine-protein kinase WNK2 (EC 2.7.11.1) (Antigen NY-CO-43) (Protein kinase lysine-deficient 2) (Protein kinase with no lysine 2) (Serologically defined colon cancer antigen 43)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; chloride channel inhibitor activity [GO:0019869]; potassium channel inhibitor activity [GO:0019870]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; ion homeostasis [GO:0050801]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of sodium ion transport [GO:0010766]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion import [GO:1903288]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:11571656}; IsoId=Q9Y3S1-1; Sequence=Displayed; Name=2 {ECO:0000303|PubMed:11214970}; IsoId=Q9Y3S1-2; Sequence=VSP_050643, VSP_050644, VSP_050647; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000269|PubMed:11280764}; IsoId=Q9Y3S1-3; Sequence=VSP_050639, VSP_050640, VSP_050641, VSP_050642; Note=Incomplete sequence. {ECO:0000269|PubMed:11280764}; Name=4 {ECO:0000303|PubMed:15489334}; IsoId=Q9Y3S1-4; Sequence=VSP_050645, VSP_050646; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17667937, ECO:0000269|PubMed:18593598}. Cell membrane {ECO:0000269|PubMed:18593598}.


uniprotID: O95785
geneSymbol: WIZ
name: Protein Wiz (Widely-interspaced zinc finger-containing protein) (Zinc finger protein 803)
length: 1651
go: ENSG00000011451;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; SET domain binding [GO:0070984]; positive regulation of nuclear cell cycle DNA replication [GO:0010571]; protein heterotrimerization [GO:0070208]; protein stabilization [GO:0050821]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O95785-1; Sequence=Displayed; Name=2; IsoId=O95785-2; Sequence=VSP_024951, VSP_024952; Name=3; IsoId=O95785-3; Sequence=VSP_054509, VSP_054510, VSP_054511; Note=No experimental confirmation available. {ECO:0000244|PubMed:25218447, ECO:0000244|PubMed:25772364, ECO:0000244|PubMed:28112733}; Name=4; IsoId=O95785-4; Sequence=VSP_057207, VSP_057208; Note=No experimental confirmation available. {ECO:0000244|PubMed:25218447, ECO:0000244|PubMed:25772364, ECO:0000244|PubMed:28112733}; 


uniprotID: Q9H6D3
geneSymbol: XKR8
name: XK-related protein 8 (hXkr8) [Cleaved into: XK-related protein 8, processed form]
length: 395
go: ENSG00000158156;
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; engulfment of apoptotic cell [GO:0043652]; phosphatidylserine exposure on apoptotic cell surface [GO:0070782]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23845944}; Multi-pass membrane protein {ECO:0000269|PubMed:23845944}.


uniprotID: O75554
geneSymbol: WBP4
reactome: R-HSA-72163;
pdb: 2DK1;2JXW;5O9Z;
length: 376
go: ENSG00000120688;
name:
WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; nucleic acid binding [GO:0003676]; proline-rich region binding [GO:0070064]; zinc ion binding [GO:0008270]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75554-1; Sequence=Displayed; Name=2; IsoId=O75554-2; Sequence=VSP_056413; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:19592703, ECO:0000269|PubMed:9724750}.


uniprotID: Q6PJI9
geneSymbol: WDR59
name: GATOR complex protein WDR59 (WD repeat-containing protein 59)
length: 974
go: ENSG00000103091;
snps: rs11557260
location: SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}.
sequence:

opentargets:
GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]; cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6PJI9-1; Sequence=Displayed; Name=2; IsoId=Q6PJI9-2; Sequence=VSP_023884; Note=No experimental confirmation available.; Name=3; IsoId=Q6PJI9-3; Sequence=VSP_023882; Name=4; IsoId=Q6PJI9-4; Sequence=VSP_023881, VSP_023883; Note=No experimental confirmation available.; 


uniprotID: Q86Y38
geneSymbol: XYLT1
reactome: R-HSA-1971475;
pdb: 6EJ7;6EJ8;6EJ9;6EJA;6EJB;6EJC;6EJD;6EJE;6FOA;
length: 959
go: ENSG00000103489;
name:
Xylosyltransferase 1 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase I) (XT-I) (XylT-I)

sequence:

opentargets:
extracellular space [GO:0005615]; Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; acetylglucosaminyltransferase activity [GO:0008375]; metal ion binding [GO:0046872]; protein xylosyltransferase activity [GO:0030158]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; embryonic skeletal system development [GO:0048706]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; ossification involved in bone maturation [GO:0043931]; proteoglycan biosynthetic process [GO:0030166]

snps:
rs61758388 rs28709752 rs201009902 rs587777366 rs587777367 rs79030430 rs12325439 rs7200466 rs35309694 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23982343, ECO:0000269|PubMed:28462984}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:11087729, ECO:0000269|PubMed:16571645}. Note=Detected predominantly in the Golgi apparatus. {ECO:0000269|PubMed:28462984}.


uniprotID: Q8IUA0
geneSymbol: WFDC8
name: WAP four-disulfide core domain protein 8 (Putative protease inhibitor WAP8)
length: 241
go: ENSG00000158901;
opentargets: extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]
snps: rs2272955 rs2250860
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:


uniprotID: Q5T750
geneSymbol: XP32
name: Skin-specific protein 32
length: 250
go: ENSG00000198854;
snps: rs1332500 rs873775 rs59194678
sequence:

opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; structural molecule activity [GO:0005198]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]


uniprotID: Q2TBF2
geneSymbol: WSCD2
name: WSC domain-containing protein 2
length: 565
go: ENSG00000075035;
opentargets: integral component of membrane [GO:0016021]
snps: rs3764002
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2TBF2-1; Sequence=Displayed; Name=2; IsoId=Q2TBF2-2; Sequence=VSP_028211; Note=No experimental confirmation available.; 


uniprotID: P0C1S8
geneSymbol: WEE2
pdb: 5VDK;
name: Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase)
length: 567
go: ENSG00000214102;
snps: rs35672788 rs200610853 rs55901099 rs35683659
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11029659, ECO:0000269|PubMed:29606300}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; female meiotic nuclear division [GO:0007143]; female pronucleus assembly [GO:0035038]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of oocyte maturation [GO:1900194]; regulation of meiosis I [GO:0060631]


uniprotID: Q5JTN6
geneSymbol: WDR38
name: WD repeat-containing protein 38
length: 314
go: ENSG00000136918;
snps: rs2274970 rs10760381
sequence:


uniprotID: P12956
geneSymbol: XRCC6
reactome: R-HSA-164843;R-HSA-1834949;R-HSA-3270619;R-HSA-5693571;R-HSA-6798695;
pdb: 1JEQ;1JEY;1JJR;3RZX;5Y3R;
length: 609
go: ENSG00000196419;
name:
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear chromosome, telomeric region [GO:0000784]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; secretory granule lumen [GO:0034774]; transcription factor complex [GO:0005667]; 5'-deoxyribose-5-phosphate lyase activity [GO:0051575]; ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; cyclin binding [GO:0030332]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; protein C-terminus binding [GO:0008022]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription regulatory region DNA binding [GO:0044212]; activation of innate immune response [GO:0002218]; brain development [GO:0007420]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to gamma radiation [GO:0071480]; cellular response to X-ray [GO:0071481]; DNA ligation [GO:0006266]; DNA recombination [GO:0006310]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; innate immune response [GO:0045087]; negative regulation of transcription, DNA-templated [GO:0045892]; neutrophil degranulation [GO:0043312]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of type I interferon production [GO:0032481]; protein heterotetramerization [GO:0051290]; regulation of smooth muscle cell proliferation [GO:0048660]; telomere maintenance [GO:0000723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P12956-1; Sequence=Displayed; Name=2; IsoId=P12956-2; Sequence=VSP_056030; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22442688}. Chromosome {ECO:0000269|PubMed:22442688}.


uniprotID: Q8NEZ3
geneSymbol: WDR19
reactome: R-HSA-5610787;R-HSA-5620924;
name: WD repeat-containing protein 19 (Intraflagellar transport 144 homolog)
length: 1342
go: ENSG00000157796;
sequence:

opentargets:
ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; intraciliary transport particle A [GO:0030991]; motile cilium [GO:0031514]; non-motile cilium [GO:0097730]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; cell morphogenesis [GO:0000902]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; digestive system development [GO:0055123]; ear morphogenesis [GO:0042471]; embryonic camera-type eye development [GO:0031076]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; intraciliary retrograde transport [GO:0035721]; intraciliary transport involved in cilium assembly [GO:0035735]; myotome development [GO:0061055]; nervous system process [GO:0050877]; smoothened signaling pathway involved in dorsal/ventral neural tube patterning [GO:0060831]

snps:
rs387906982 rs776967770 rs786204852 rs766029437 rs199812132 rs387906983 rs587777349 rs387906980 rs16995209 rs79436363 rs587777351 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NEZ3-1; Sequence=Displayed; Name=2; IsoId=Q8NEZ3-2; Sequence=VSP_018073, VSP_018074; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q3UGF1}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3UGF1}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q3UGF1}. Note=Localizes to photoreceptor connecting cilia, to the base of motile cilia in brain ependymal cells and to the base of and along primary cilia in kidney cells. {ECO:0000250|UniProtKB:Q3UGF1}.


uniprotID: Q12768
geneSymbol: WASHC5
name: WASH complex subunit 5 (Strumpellin) (WASH complex subunit strumpellin)
length: 1159
go: ENSG00000164961;
snps: rs755285830 rs80338865 rs80338866 rs80338867 rs397515564
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]; endosomal transport [GO:0016197]; oocyte maturation [GO:0001556]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of neuron projection development [GO:0010976]; protein transport [GO:0015031]; spindle assembly involved in meiosis [GO:0090306]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20833645}. Endoplasmic reticulum {ECO:0000269|PubMed:20833645}. Early endosome {ECO:0000269|PubMed:23085491, ECO:0000269|PubMed:23676666}. Note=Colocalizes with SYP/synaptophysin in the external molecular layer of the dentate gyrus and in motoneurons of the ventral horn of spinal cord. {ECO:0000269|PubMed:20833645}.


uniprotID: Q3MJ13
geneSymbol: WDR72
name: WD repeat-containing protein 72
length: 1102
go: ENSG00000166415;
opentargets: cytoplasm [GO:0005737]; endosome [GO:0005768]; enamel mineralization [GO:0070166]
snps: rs690346 rs35258188 rs34123953 rs60404950 rs17730281 rs16966320
location: SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:D3YYM4}.
sequence:


uniprotID: Q9GZL7
geneSymbol: WDR12
reactome: R-HSA-6791226;
name: Ribosome biogenesis protein WDR12 (WD repeat-containing protein 12)
length: 423
go: ENSG00000138442;
snps: rs35212307 rs751438871
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex binding [GO:0043021]; cell proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; Notch signaling pathway [GO:0007219]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16043514, ECO:0000269|PubMed:26601951}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029, ECO:0000269|PubMed:16043514}.


uniprotID: Q8WWM1
geneSymbol: XAGE5
length: 108
name:
X antigen family member 5 (XAGE-5) (Cancer/testis antigen 12.5) (CT12.5) (G antigen family D member 5)

sequence:
MSWRGRRYRPRRCLRLAQLVGPMLEPSVPEPQQEEPPTESQDHTPGQKREDDQGAAEIQVPNLEADLQELSQSKTGDECGDSPDVQGKILPKSEQFKMPEGGEGKPQL


uniprotID: C4AMC7
geneSymbol: WASH3P
name: Putative WAS protein family homolog 3 (Protein FAM39DP)
length: 463
sequence:

opentargets:
autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; early endosome to late endosome transport [GO:0045022]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein targeting to lysosome [GO:0006622]; retrograde transport, endosome to Golgi [GO:0042147]

location:
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:20175130, ECO:0000269|PubMed:20498093}. Early endosome membrane {ECO:0000250|UniProtKB:A8K0Z3}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Cell projection, lamellipodium {ECO:0000269|PubMed:18159949}. Cell projection, filopodium {ECO:0000269|PubMed:18159949}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2. Localizes to MMP14-positive late endosomes and transiently to invadipodia (By similarity). Localized to Salmonella typhimurium entry sites (By similarity). {ECO:0000250|UniProtKB:A8K0Z3, ECO:0000250|UniProtKB:Q8VDD8}.


uniprotID: P98170
geneSymbol: XIAP
length: 497
go: ENSG00000101966;
snps: rs28382721 rs28382722 rs28382723 rs5956583
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
reactome:
R-HSA-111463;R-HSA-111464;R-HSA-3769402;R-HSA-5213460;R-HSA-5357905;R-HSA-5357956;R-HSA-5675482;R-HSA-8948747;R-HSA-8948751;

pdb:
1C9Q;1F9X;1G3F;1G73;1I3O;1I4O;1I51;1KMC;1NW9;1TFQ;1TFT;2ECG;2JK7;2KNA;2OPY;2OPZ;2POI;2POP;2QRA;2VSL;3CLX;3CM2;3CM7;3EYL;3G76;3HL5;3UW4;3UW5;4EC4;4HY0;4IC2;4IC3;4J3Y;4J44;4J45;4J46;4J47;4J48;4KJU;4KJV;4KMP;4MTZ;4OXC;4WVS;4WVT;4WVU;5C0K;5C0L;5C3H;5C3K;5C7A;5C7B;5C7C;5C7D;5C83;5C84;5M6E;5M6F;5M6H;5M6L;5M6M;5O6T;5OQW;6EY2;

name:
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; copper ion homeostasis [GO:0055070]; inhibition of cysteine-type endopeptidase activity involved in apoptotic process [GO:1990001]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of protein linear polyubiquitination [GO:1902530]; positive regulation of protein ubiquitination [GO:0031398]; regulation of BMP signaling pathway [GO:0030510]; regulation of cell proliferation [GO:0042127]; regulation of inflammatory response [GO:0050727]; regulation of innate immune response [GO:0045088]; regulation of nucleotide-binding oligomerization domain containing signaling pathway [GO:0070424]; Wnt signaling pathway [GO:0016055]


uniprotID: Q9Y6F9
geneSymbol: WNT6
reactome: R-HSA-3238698;R-HSA-373080;
name: Protein Wnt-6
length: 365
go: ENSG00000115596;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; axis specification [GO:0009798]; branching involved in ureteric bud morphogenesis [GO:0001658]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; cornea development in camera-type eye [GO:0061303]; epithelial-mesenchymal cell signaling [GO:0060684]; nephron tubule formation [GO:0072079]; neuron differentiation [GO:0030182]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of gene expression [GO:0010628]; positive regulation of tooth mineralization [GO:0070172]; positive regulation of transcription, DNA-templated [GO:0045893]; Wnt signaling pathway [GO:0016055]


uniprotID: Q5GH70
geneSymbol: XKR9
name: XK-related protein 9
length: 373
go: ENSG00000221947;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9NYS7
geneSymbol: WSB2
reactome: R-HSA-8951664;
name: WD repeat and SOCS box-containing protein 2 (WSB-2) (CS box-containing WD protein)
length: 404
go: ENSG00000176871;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NYS7-1; Sequence=Displayed; Name=2; IsoId=Q9NYS7-2; Sequence=VSP_054016; Note=No experimental confirmation available.; Name=3; IsoId=Q9NYS7-3; Sequence=VSP_054576; Note=No experimental confirmation available.; 


uniprotID: B2RUY7
geneSymbol: VWC2L
name: von Willebrand factor C domain-containing protein 2-like (Brorin-like)
length: 222
go: ENSG00000174453;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell junction, synapse {ECO:0000250}.
sequence:

opentargets:
AMPA glutamate receptor complex [GO:0032281]; cell junction [GO:0030054]; extracellular space [GO:0005615]; synapse [GO:0045202]; negative regulation of BMP signaling pathway [GO:0030514]; positive regulation of neuron differentiation [GO:0045666]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=B2RUY7-1; Sequence=Displayed; Name=2; IsoId=B2RUY7-2; Sequence=VSP_035088, VSP_035089; 


uniprotID: Q9NP79
geneSymbol: VTA1
reactome: R-HSA-162588;R-HSA-917729;
pdb: 2LXL;2LXM;4TXP;4TXQ;4TXR;4U7E;
length: 307
go: ENSG00000009844;
snps: rs2232307
name:
Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1)

sequence:

opentargets:
cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; protein C-terminus binding [GO:0008022]; ESCRT III complex disassembly [GO:1904903]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; multivesicular body sorting pathway [GO:0071985]; protein transport [GO:0015031]; viral budding [GO:0046755]; viral life cycle [GO:0019058]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NP79-1; Sequence=Displayed; Name=2; IsoId=Q9NP79-2; Sequence=VSP_056727, VSP_056728; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15644320}. Endosome membrane {ECO:0000305|PubMed:15644320}; Peripheral membrane protein {ECO:0000305|PubMed:15644320}.


uniprotID: Q8IWB7
geneSymbol: WDFY1
length: 410
go: ENSG00000085449;
location: SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11739631, ECO:0000269|PubMed:25736436}.
name:
WD repeat and FYVE domain-containing protein 1 (FYVE domain-containing protein localized to endosomes 1) (FENS-1) (Phosphoinositide-binding protein 1) (WD40- and FYVE domain-containing protein 1) (Zinc finger FYVE domain-containing protein 17)

sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634]; 1-phosphatidylinositol binding [GO:0005545]; zinc ion binding [GO:0008270]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]


uniprotID: Q8WVS4
geneSymbol: WDR60
reactome: R-HSA-5620924;
name: WD repeat-containing protein 60
length: 1066
go: ENSG00000126870;
snps: rs17837851 rs2788478 rs587777065
sequence:

opentargets:
ciliary base [GO:0097546]; ciliary tip [GO:0097542]; cilium [GO:0005929]; cytoplasmic dynein complex [GO:0005868]; dynein complex [GO:0030286]; extracellular space [GO:0005615]; pericentriolar material [GO:0000242]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; cilium assembly [GO:0060271]; embryonic skeletal system morphogenesis [GO:0048704]; intraciliary transport involved in cilium assembly [GO:0035735]; microtubule-based movement [GO:0007018]

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:23910462}. Note=Located at the base of the primary cilium in serum-starved fibroblasts.


uniprotID: Q96S15
geneSymbol: WDR24
name: GATOR complex protein WDR24 (WD repeat-containing protein 24)
length: 920
go: ENSG00000127580;
location: SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28199306}.
sequence:

opentargets:
GATOR2 complex [GO:0061700]; lysosomal membrane [GO:0005765]; autophagy [GO:0006914]; cellular response to amino acid starvation [GO:0034198]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96S15-1; Sequence=Displayed; Name=2; IsoId=Q96S15-2; Sequence=VSP_016180, VSP_016181; 


uniprotID: Q13426
geneSymbol: XRCC4
reactome: R-HSA-164843;R-HSA-3108214;R-HSA-5693571;
pdb: 1FU1;1IK9;3II6;3MUD;3Q4F;3RWR;3SR2;3W03;4XA4;5CHX;5CJ0;5CJ4;5E50;5WJ7;5WLZ;
name: DNA repair protein XRCC4 (X-ray repair cross-complementing protein 4)
length: 336
go: ENSG00000152422;
drug: DB03963;
snps: rs28383138 rs587779351 rs28383151 rs28360135 rs28360136 rs797045017 rs2974446 rs3734091
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:9259561}.
sequence:

opentargets:
cytosol [GO:0005829]; DNA ligase IV complex [GO:0032807]; DNA-dependent protein kinase-DNA ligase 4 complex [GO:0005958]; nonhomologous end joining complex [GO:0070419]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; protein C-terminus binding [GO:0008022]; cellular response to lithium ion [GO:0071285]; DNA ligation involved in DNA repair [GO:0051103]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; positive regulation of ligase activity [GO:0051351]; response to X-ray [GO:0010165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13426-1; Sequence=Displayed; Name=2; IsoId=Q13426-2; Sequence=VSP_009473; Name=3; IsoId=Q13426-3; Sequence=VSP_009474; 


uniprotID: Q8NA23
geneSymbol: WDR31
name: WD repeat-containing protein 31
length: 367
go: ENSG00000148225;
snps: rs10817479
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NA23-1; Sequence=Displayed; Name=2; IsoId=Q8NA23-2; Sequence=VSP_010418; Note=No experimental confirmation available.; 


uniprotID: Q1A5X7
geneSymbol: WHAMMP3
length: 153
name:
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1 (WAS protein homolog associated with actin, Golgi membranes and microtubules pseudogene 3) (WAS protein homology region 2 domain-containing protein 1-like protein 1) (WH2 domain-containing protein 1-like protein 1) (WHDC1-like protein 1)

sequence:
MMILVFWSNYPYEPVCLASHRNNMEASVPKYKKHLPQLGMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELCLNHKRAEIQGKMEDLPEQEKNINVVDELAIQFYEIQLELYEVKFEILKNKEILLTTQLDSLERLIKDEI

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Arp2/3 complex binding [GO:0071933]; GTP-Rho binding [GO:0017049]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell cycle arrest [GO:0007050]; ER to Golgi vesicle-mediated transport [GO:0006888]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; Synonyms=II; IsoId=Q1A5X7-1; Sequence=Displayed; Name=1; Synonyms=I; IsoId=Q1A5X7-2; Sequence=VSP_030789, VSP_030790; Note=No experimental confirmation available.; 


uniprotID: O00744
geneSymbol: WNT10B
reactome: R-HSA-3238698;R-HSA-373080;R-HSA-381340;
name: Protein Wnt-10b (Protein Wnt-12)
length: 389
go: ENSG00000169884;
snps: rs151284263 rs779326570 rs146010731 rs35034312 rs121918349
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; bone trabecula formation [GO:0060346]; canonical Wnt signaling pathway [GO:0060070]; cell cycle arrest [GO:0007050]; cell fate commitment [GO:0045165]; cellular response to cAMP [GO:0071320]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to retinoic acid [GO:0071300]; chondrocyte differentiation [GO:0002062]; fungiform papilla development [GO:0061196]; G2/M transition of mitotic cell cycle [GO:0000086]; hematopoietic stem cell proliferation [GO:0071425]; lipid metabolic process [GO:0006629]; myoblast differentiation involved in skeletal muscle regeneration [GO:0014835]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron differentiation [GO:0030182]; positive regulation of apoptotic process [GO:0043065]; positive regulation of bone mineralization [GO:0030501]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of epithelial cell differentiation [GO:0030858]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of timing of anagen [GO:0051885]; protein stabilization [GO:0050821]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of skeletal muscle tissue development [GO:0048641]; sensory perception of taste [GO:0050909]; skeletal muscle fiber development [GO:0048741]; smoothened signaling pathway [GO:0007224]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00744-1; Sequence=Displayed; Name=2; IsoId=O00744-2; Sequence=VSP_056289, VSP_056290; Note=No experimental confirmation available.; 


uniprotID: Q2M389
geneSymbol: WASHC4
length: 1173
go: ENSG00000136051;
snps: rs34434425 rs1345092 rs1663564 rs587777411
location: SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23676666}.
name:
WASH complex subunit 4 (Strumpellin and WASH-interacting protein) (SWIP) (WASH complex subunit SWIP)

sequence:

opentargets:
early endosome [GO:0005769]; endosome [GO:0005768]; nucleoplasm [GO:0005654]; WASH complex [GO:0071203]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2M389-1; Sequence=Displayed; Name=2; IsoId=Q2M389-2; Sequence=VSP_024208, VSP_024209; 


uniprotID: Q6RFH5
geneSymbol: WDR74
name: WD repeat-containing protein 74 (NOP seven-associated protein 1)
length: 385
go: ENSG00000133316;
sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; blastocyst formation [GO:0001825]; ribosomal large subunit biogenesis [GO:0042273]; RNA metabolic process [GO:0016070]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6RFH5-1; Sequence=Displayed; Name=2; IsoId=Q6RFH5-2; Sequence=VSP_011957; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:28416111, ECO:0000269|PubMed:29107693}. Nucleus {ECO:0000269|PubMed:28416111}. Note=Nucleolar location depends on active PolI transcription of pre-rRNA. {ECO:0000269|PubMed:28416111}.


uniprotID: Q96AJ9
geneSymbol: VTI1A
reactome: R-HSA-6811438;R-HSA-6811440;
length: 217
go: ENSG00000151532;
name:
Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)

sequence:

opentargets:
autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; neuron projection terminus [GO:0044306]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; autophagy [GO:0006914]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi ribbon formation [GO:0090161]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein targeting to vacuole [GO:0006623]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle fusion with Golgi apparatus [GO:0048280]; voluntary musculoskeletal movement [GO:0050882]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=Q96AJ9-2; Sequence=Displayed; Name=1; IsoId=Q96AJ9-1; Sequence=VSP_039848; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:19138172}. Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.


uniprotID: Q96QU8
geneSymbol: XPO6
name: Exportin-6 (Exp6) (Ran-binding protein 20)
length: 1125
go: ENSG00000169180;
snps: rs14672
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein transporter activity [GO:0008565]; Ran GTPase binding [GO:0008536]; protein export from nucleus [GO:0006611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96QU8-1; Sequence=Displayed; Name=2; IsoId=Q96QU8-2; Sequence=VSP_055756; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14592989}. Cytoplasm {ECO:0000269|PubMed:14592989}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:14592989}.


uniprotID: Q8TF30
geneSymbol: WHAMM
pdb: 5X1G;
length: 809
go: ENSG00000156232;
snps: rs35270670 rs1055666 rs1055667 rs3814281 rs11259953 rs11259954
name:
WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; microtubule [GO:0005874]; actin binding [GO:0003779]; Arp2/3 complex binding [GO:0071933]; GTP-Rho binding [GO:0017049]; microtubule binding [GO:0008017]; actin filament organization [GO:0007015]; actin filament reorganization [GO:0090527]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; cell cycle arrest [GO:0007050]; ER to Golgi vesicle-mediated transport [GO:0006888]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; plasma membrane tubulation [GO:0097320]; positive regulation of actin nucleation [GO:0051127]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18614018}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:18614018}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18614018}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18614018}. Note=Localized to a perinuclear compartment near the microtubule-organizing center (MTOC). Also detected on tubulo-vesicular structures in the cell periphery that frequently localized along microtubules. {ECO:0000269|PubMed:18614018}.


uniprotID: O00755
geneSymbol: WNT7A
reactome: R-HSA-3238698;R-HSA-373080;
pdb: 4UZQ;
name: Protein Wnt-7a
length: 349
go: ENSG00000154764;
snps: rs397514666 rs879255548 rs104893832 rs397514643 rs104893835
sequence:

opentargets:
cell surface [GO:0009986]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; asymmetric protein localization involved in cell fate determination [GO:0045167]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cartilage condensation [GO:0001502]; cell fate commitment [GO:0045165]; cell proliferation in forebrain [GO:0021846]; cellular response to transforming growth factor beta stimulus [GO:0071560]; central nervous system vasculogenesis [GO:0022009]; cerebellar granule cell differentiation [GO:0021707]; chondrocyte differentiation [GO:0002062]; dendritic spine morphogenesis [GO:0060997]; dorsal/ventral pattern formation [GO:0009953]; embryonic axis specification [GO:0000578]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; establishment of cell polarity [GO:0030010]; excitatory synapse assembly [GO:1904861]; lens fiber cell development [GO:0070307]; negative regulation of apoptotic process [GO:0043066]; negative regulation of neurogenesis [GO:0050768]; neuron differentiation [GO:0030182]; neurotransmitter secretion [GO:0007269]; oviduct development [GO:0060066]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of epithelial cell proliferation involved in wound healing [GO:0060054]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of excitatory synapse assembly [GO:1904891]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein localization to presynapse [GO:1905386]; positive regulation of synapse assembly [GO:0051965]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; regulation of axon diameter [GO:0031133]; regulation of postsynapse organization [GO:0099175]; regulation of presynapse assembly [GO:1905606]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; secondary palate development [GO:0062009]; sex differentiation [GO:0007548]; skeletal muscle satellite cell activation [GO:0014719]; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [GO:0014834]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; stem cell development [GO:0048864]; synaptic vesicle recycling [GO:0036465]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing, spreading of epidermal cells [GO:0035313]


uniprotID: Q96N03
geneSymbol: VSTM2L
name: V-set and transmembrane domain-containing protein 2-like protein
length: 204
go: ENSG00000132821;
sequence:

opentargets:
axon [GO:0030424]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of neuron apoptotic process [GO:0043524]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96N03-1; Sequence=Displayed; Name=2; IsoId=Q96N03-2; Sequence=VSP_013380, VSP_026514; Note=Gene prediction based on EST data.; Name=3; IsoId=Q96N03-3; Sequence=VSP_026512, VSP_026513; Note=Gene prediction based on EST data.; 


uniprotID: Q658N2
geneSymbol: WSCD1
name: WSC domain-containing protein 1
length: 575
go: ENSG00000179314;
opentargets: integral component of membrane [GO:0016021]; sulfotransferase activity [GO:0008146]
snps: rs17855415
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8WTZ3
name: Zinc finger protein ENSP00000375192
length: 238
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: A8K0Z3
geneSymbol: WASHC1
length: 465
go: ENSG00000181404;
name:
WASH complex subunit 1 (CXYorf1-like protein on chromosome 9) (Protein FAM39E) (WAS protein family homolog 1)

sequence:

opentargets:
autophagosome [GO:0005776]; centriole [GO:0005814]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; invadopodium [GO:0071437]; late endosome [GO:0005770]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; WASH complex [GO:0071203]; actin binding [GO:0003779]; alpha-tubulin binding [GO:0043014]; ubiquitin protein ligase binding [GO:0031625]; Arp2/3 complex-mediated actin nucleation [GO:0034314]; endosomal transport [GO:0016197]; exocytosis [GO:0006887]; extracellular matrix disassembly [GO:0022617]; negative regulation of autophagy [GO:0010507]; negative regulation of phosphatidylinositol 3-kinase activity [GO:0043553]; positive regulation of cell migration [GO:0030335]; positive regulation of pseudopodium assembly [GO:0031274]; protein transport [GO:0015031]; regulation of protein ubiquitination [GO:0031396]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, endosome to plasma membrane [GO:1990126]

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:19922874}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8VDD8}. Late endosome {ECO:0000269|PubMed:22114305, ECO:0000269|PubMed:24344185}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8VDD8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8VDD8}. Note=Localization to the endosome membrane is mediated via its interaction with WASHC2 (PubMed:19922874). Localizes to MMP14-positive late endosomes and transiently to invadipodia (PubMed:24344185). Localized to Salmonella typhimurium entry sites (By similarity). {ECO:0000250|UniProtKB:Q8VDD8, ECO:0000269|PubMed:19922874, ECO:0000269|PubMed:24344185}.


uniprotID: Q8TBZ3
geneSymbol: WDR20
reactome: R-HSA-5689880;
pdb: 5K19;5K1C;
name: WD repeat-containing protein 20 (Protein DMR)
length: 569
go: ENSG00000140153;
snps: rs17852545 rs12888595
sequence:

opentargets:
nucleoplasm [GO:0005654]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q8TBZ3-1; Sequence=Displayed; Name=2; IsoId=Q8TBZ3-2; Sequence=VSP_024387; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBZ3-3; Sequence=VSP_043412, VSP_043413; Note=No experimental confirmation available.; Name=4; IsoId=Q8TBZ3-4; Sequence=VSP_045225, VSP_045226; Note=No experimental confirmation available.; Name=5; IsoId=Q8TBZ3-5; Sequence=VSP_045226; Note=No experimental confirmation available.; Name=6; IsoId=Q8TBZ3-6; Sequence=VSP_045226, VSP_024387; Note=No experimental confirmation available.; Name=7; IsoId=Q8TBZ3-7; Sequence=VSP_047065; Name=8; IsoId=Q8TBZ3-8; Sequence=VSP_047064; Note=No experimental confirmation available.; 


uniprotID: Q8IZU2
geneSymbol: WDR17
name: WD repeat-containing protein 17
length: 1322
go: ENSG00000150627;
snps: rs59567138 rs4690661 rs7693453 rs6810394 rs17625943 rs11736872
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IZU2-1; Sequence=Displayed; Name=2; IsoId=Q8IZU2-2; Sequence=VSP_047201, VSP_047202; Note=No experimental confirmation available.; 


uniprotID: Q9UBH6
geneSymbol: XPR1
pdb: 5IJH;
length: 696
go: ENSG00000143324;
snps: rs786205902 rs786205903 rs786205901 rs786205904 rs1061012
name:
Xenotropic and polytropic retrovirus receptor 1 (Protein SYG1 homolog) (Xenotropic and polytropic murine leukemia virus receptor X3) (X-receptor)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intrinsic component of plasma membrane [GO:0031226]; plasma membrane [GO:0005886]; efflux transmembrane transporter activity [GO:0015562]; G protein-coupled receptor activity [GO:0004930]; inositol hexakisphosphate binding [GO:0000822]; phosphate ion transmembrane transporter activity [GO:0015114]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; virus receptor activity [GO:0001618]; cellular phosphate ion homeostasis [GO:0030643]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphate ion transmembrane transport [GO:0035435]; response to virus [GO:0009615]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UBH6-1; Sequence=Displayed; Name=2; IsoId=Q9UBH6-2; Sequence=VSP_030748; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23791524}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q96NZ8
geneSymbol: WFIKKN1
pdb: 2DDI;2DDJ;
length: 548
go: ENSG00000127578;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 (Growth and differentiation factor-associated serum protein 2) (GASP-2) (hGASP-2) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein)

sequence:

opentargets:
extracellular region [GO:0005576]; metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]; muscle fiber development [GO:0048747]; negative regulation of DNA binding [GO:0043392]; negative regulation of protein binding [GO:0032091]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]


uniprotID: Q641Q2
geneSymbol: WASHC2A
name: WASH complex subunit 2A
length: 1341
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203]; lipid binding [GO:0008289]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q641Q2-1; Sequence=Displayed; Name=2; IsoId=Q641Q2-2; Sequence=VSP_030948; 

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q9Y4E1}. Cell membrane {ECO:0000250|UniProtKB:Q9Y4E1}.


uniprotID: O76076
geneSymbol: WISP2
length: 250
go: ENSG00000064205;
snps: rs33932543
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
WNT1-inducible-signaling pathway protein 2 (WISP-2) (CCN family member 5) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58)

sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of cell death [GO:0060548]; regulation of cell growth [GO:0001558]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O76076-1; Sequence=Displayed; Name=2; IsoId=O76076-2; Sequence=VSP_056298, VSP_056299; Note=No experimental confirmation available.; 


uniprotID: Q15061
geneSymbol: WDR43
reactome: R-HSA-6790901;R-HSA-6791226;
name: WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)
length: 677
go: ENSG00000163811;
sequence:

opentargets:
fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24219289}. Note=Found predominantly at the fibrillar center. {ECO:0000269|PubMed:24219289}.


uniprotID: P09544
geneSymbol: WNT2
reactome: R-HSA-3238698;R-HSA-373080;
name: Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP)
length: 360
go: ENSG00000105989;
snps: rs145839592 rs1051751 rs148046128
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extrinsic component of external side of plasma membrane [GO:0031232]; Wnt signalosome [GO:1990909]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; cardiac epithelial to mesenchymal transition [GO:0060317]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; iris morphogenesis [GO:0061072]; labyrinthine layer blood vessel development [GO:0060716]; lens development in camera-type eye [GO:0002088]; lung development [GO:0030324]; lung induction [GO:0060492]; mammary gland epithelium development [GO:0061180]; midbrain dopaminergic neuron differentiation [GO:1904948]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation involved in lung morphogenesis [GO:0060501]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:20018874}.


uniprotID: O95389
geneSymbol: WISP3
name: WNT1-inducible-signaling pathway protein 3 (WISP-3) (CCN family member 6)
length: 354
go: ENSG00000112761;
snps: rs1230345 rs17073260 rs121908902
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; negative regulation of cell death [GO:0060548]; regulation of cell growth [GO:0001558]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95389-1; Sequence=Displayed; Name=2; IsoId=O95389-2; Sequence=VSP_037803; 


uniprotID: Q9H967
geneSymbol: WDR76
name: WD repeat-containing protein 76
length: 626
go: ENSG00000092470;
snps: rs678084 rs3742985
sequence:

opentargets:
heterochromatin [GO:0000792]; nucleus [GO:0005634]; site of DNA damage [GO:0090734]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; cellular response to DNA damage stimulus [GO:0006974]; regulation of DNA damage checkpoint [GO:2000001]


uniprotID: Q9H1B5
geneSymbol: XYLT2
reactome: R-HSA-1971475;
length: 865
go: ENSG00000015532;
snps: rs113835371 rs739990 rs748114111 rs12451299 rs72832454 rs6504649
name:
Xylosyltransferase 2 (EC 2.4.2.26) (Peptide O-xylosyltransferase 1) (Xylosyltransferase II) (XT-II) (XylT-II)

sequence:

opentargets:
extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; acetylglucosaminyltransferase activity [GO:0008375]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; protein xylosyltransferase activity [GO:0030158]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan metabolic process [GO:0030203]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparin biosynthetic process [GO:0030210]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H1B5-1; Sequence=Displayed; Name=2; IsoId=Q9H1B5-2; Sequence=VSP_013758, VSP_013759; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:17189265, ECO:0000269|PubMed:25748573}.


uniprotID: O00308
geneSymbol: WWP2
reactome: R-HSA-8948751;R-HSA-9013507;
pdb: 4Y07;5TJ7;5TJ8;5TJQ;
length: 870
go: ENSG00000198373;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:20858735}.
name:
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; RNA polymerase II transcription factor binding [GO:0001085]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein modification process [GO:0006464]; extracellular transport [GO:0006858]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of gene expression [GO:0010629]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of protein transport [GO:0051224]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transporter activity [GO:0032410]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of ion transmembrane transport [GO:0034765]; regulation of membrane potential [GO:0042391]; regulation of potassium ion transmembrane transporter activity [GO:1901016]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral entry into host cell [GO:0046718]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O00308-1; Sequence=Displayed; Name=2; IsoId=O00308-2; Sequence=VSP_044706; Note=No experimental confirmation available.; Name=3; IsoId=O00308-3; Sequence=VSP_046461; Note=No experimental confirmation available.; Name=4; IsoId=O00308-4; Sequence=VSP_054711; Note=No experimental confirmation available.; 


uniprotID: Q8TEU8
geneSymbol: WFIKKN2
length: 576
go: ENSG00000173714;
snps: rs55700534 rs35300894
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
name:
WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 (Growth and differentiation factor-associated serum protein 1) (GASP-1) (hGASP-1) (WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein) (WFIKKN-related protein)

sequence:

opentargets:
extracellular space [GO:0005615]; metalloendopeptidase inhibitor activity [GO:0008191]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]; muscle fiber development [GO:0048747]; negative regulation of DNA binding [GO:0043392]; negative regulation of protein binding [GO:0032091]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; roof of mouth development [GO:0060021]; skeletal system development [GO:0001501]; transforming growth factor beta receptor signaling pathway [GO:0007179]


uniprotID: O75063
geneSymbol: FAM20B
name: Glycosaminoglycan xylosylkinase (EC 2.7.1.-) (Xylose kinase)
length: 409
go: ENSG00000116199;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; metal ion binding [GO:0046872]; phosphotransferase activity, alcohol group as acceptor [GO:0016773]

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19473117}; Single-pass type II membrane protein {ECO:0000269|PubMed:19473117}.


uniprotID: Q9BUB7
geneSymbol: TMEM70
name: Transmembrane protein 70, mitochondrial
length: 260
go: ENSG00000175606;
snps: rs8075 rs35564486 rs1053079 rs1053077
sequence:

opentargets:
integral component of mitochondrial membrane [GO:0032592]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; mitochondrial proton-transporting ATP synthase complex assembly [GO:0033615]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BUB7-1; Sequence=Displayed; Name=2; IsoId=Q9BUB7-2; Sequence=VSP_020759; Note=No experimental confirmation available.; Name=3; IsoId=Q9BUB7-3; Sequence=VSP_054227, VSP_054228; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20937241}; Multi-pass membrane protein {ECO:0000269|PubMed:20937241}.


uniprotID: Q8N7C4
geneSymbol: TMEM217
name: Transmembrane protein 217
length: 229
go: ENSG00000172738;
opentargets: fibrillar center [GO:0001650]; integral component of membrane [GO:0016021]; nucleolus [GO:0005730]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N7C4-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8N7C4-2; Sequence=VSP_014386, VSP_014387; Note=No experimental confirmation available.; 


uniprotID: P51580
geneSymbol: TPMT
reactome: R-HSA-156581;R-HSA-5578995;
pdb: 2BZG;2H11;
name: Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase)
length: 245
go: ENSG00000137364;
drug: DB00993;DB00436;DB01327;DB01033;DB01250;DB01021;
snps: rs72552740 rs1800462 rs1800460 rs6921269 rs75543815 rs56161402 rs72552736 rs1142345
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
cytosol [GO:0005829]; S-adenosyl-L-methionine binding [GO:1904047]; thiopurine S-methyltransferase activity [GO:0008119]; drug metabolic process [GO:0017144]; methylation [GO:0032259]; nucleobase-containing compound metabolic process [GO:0006139]


uniprotID: P0CI26
geneSymbol: TRIM49C
name: Tripartite motif-containing protein 49C (Tripartite motif-containing protein 49-like protein 2)
length: 452
go: ENSG00000204449;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: C9J1S8
geneSymbol: TRIM49D1; TRIM49D2
length: 452
go: ENSG00000223417;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
name:
Tripartite motif-containing protein 49D (Tripartite motif-containing protein 49-like protein) (Tripartite motif-containing protein 49D1) (Tripartite motif-containing protein 49D2)

sequence:


uniprotID: O60507
geneSymbol: TPST1
reactome: R-HSA-156584;
pdb: 5WRI;5WRJ;
name: Protein-tyrosine sulfotransferase 1 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 1) (TPST-1)
length: 370
go: ENSG00000169902;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of Golgi membrane [GO:0030173]; membrane [GO:0016020]; protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; inflammatory response [GO:0006954]; peptidyl-tyrosine sulfation [GO:0006478]

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16859706, ECO:0000269|PubMed:25660941}; Single-pass type II membrane protein {ECO:0000269|PubMed:25660941, ECO:0000305|PubMed:16859706}.


uniprotID: Q15035
geneSymbol: TRAM2
name: Translocating chain-associated membrane protein 2
length: 370
go: ENSG00000065308;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; rough endoplasmic reticulum [GO:0005791]; collagen biosynthetic process [GO:0032964]; protein insertion into ER membrane [GO:0045048]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]


uniprotID: Q9C029
geneSymbol: TRIM7
length: 511
go: ENSG00000146054;
snps: rs3857300 rs2770946 rs2770945 rs416574 rs254460
name:
E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=GNIP1; IsoId=Q9C029-2; Sequence=Displayed; Name=2; Synonyms=GNIP2; IsoId=Q9C029-3; Sequence=VSP_009020; Name=3; Synonyms=GNIP3; IsoId=Q9C029-4; Sequence=VSP_009018, VSP_009019; Name=4; Synonyms=TRIM7; IsoId=Q9C029-1; Sequence=VSP_009021, VSP_009022; 


uniprotID: Q7Z4K8
geneSymbol: TRIM46
reactome: R-HSA-877300;
length: 759
go: ENSG00000163462;
name:
Tripartite motif-containing protein 46 (Gene Y protein) (GeneY) (Tripartite, fibronectin type-III and C-terminal SPRY motif protein)

sequence:

opentargets:
axon cytoplasm [GO:1904115]; axon initial segment [GO:0043194]; cytoskeleton [GO:0005856]; main axon [GO:0044304]; proximal neuron projection [GO:1990769]; zinc ion binding [GO:0008270]; anterograde synaptic vesicle transport [GO:0048490]; axonogenesis [GO:0007409]; microtubule bundle formation [GO:0001578]; negative regulation of axon extension [GO:0030517]; neuron migration [GO:0001764]; positive regulation of anterograde dense core granule transport [GO:1901953]; protein localization to axon [GO:0099612]; regulation of cellular protein localization [GO:1903827]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q7Z4K8-1; Sequence=Displayed; Name=2; IsoId=Q7Z4K8-2; Sequence=VSP_011983, VSP_011984; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z4K8-3; Sequence=VSP_011980, VSP_011981, VSP_011982; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z4K8-4; Sequence=VSP_011981, VSP_011982; Note=No experimental confirmation available.; Name=5; IsoId=Q7Z4K8-5; Sequence=VSP_045976; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:Q7TNM2}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7TNM2}. Note=Microtubule-associated. Localizes to the proximal part of the axon. {ECO:0000250|UniProtKB:Q7TNM2}.


uniprotID: Q14258
geneSymbol: TRIM25
pdb: 4CFG;4LTB;5EYA;5FER;5NT1;5NT2;6FLM;6FLN;
length: 630
go: ENSG00000121060;
snps: rs7212260 rs205498
reactome:
R-HSA-1169408;R-HSA-168928;R-HSA-5656169;R-HSA-5689896;R-HSA-877300;R-HSA-918233;R-HSA-933541;R-HSA-933542;R-HSA-933543;R-HSA-936440;

name:
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]; DNA-binding transcription factor activity [GO:0003700]; ligase activity [GO:0016874]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cellular response to leukemia inhibitory factor [GO:1990830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of type I interferon production [GO:0032480]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein monoubiquitination [GO:0006513]; regulation of viral entry into host cell [GO:0046596]; regulation of viral release from host cell [GO:1902186]; response to estrogen [GO:0043627]; response to vitamin D [GO:0033280]; translesion synthesis [GO:0019985]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17392790}. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.


uniprotID: Q86YW5
geneSymbol: TREML1
reactome: R-HSA-198933;
pdb: 2FRG;
length: 311
go: ENSG00000161911;
snps: rs34254490
name:
Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; calcium-mediated signaling [GO:0019722]; innate immune response [GO:0045087]; platelet activation [GO:0030168]; regulation of immune response [GO:0050776]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86YW5-1; Sequence=Displayed; Name=2; Synonyms=TLT1sv; IsoId=Q86YW5-2; Sequence=VSP_021125, VSP_021126; Name=3; IsoId=Q86YW5-3; Sequence=VSP_021124; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15100151}; Single-pass type I membrane protein {ECO:0000269|PubMed:15100151}. Cytoplasm {ECO:0000269|PubMed:15100151}. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).


uniprotID: Q96Q11
geneSymbol: TRNT1
reactome: R-HSA-6784531;R-HSA-6785470;
pdb: 1OU5;4X4W;
length: 434
go: ENSG00000072756;
snps: rs334773 rs606231290 rs771781629 rs606231289 rs606231287 rs370011798 rs199931785
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11256614}.
name:
CCA tRNA nucleotidyltransferase 1, mitochondrial (EC 2.7.7.72) (Mitochondrial tRNA nucleotidyl transferase, CCA-adding) (mt CCA-adding enzyme) (mt tRNA CCA-diphosphorylase) (mt tRNA CCA-pyrophosphorylase) (mt tRNA adenylyltransferase)

sequence:

opentargets:
intracellular [GO:0005622]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; 5'-3' RNA polymerase activity [GO:0034062]; ATP binding [GO:0005524]; ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [GO:0052929]; CTP:3'-cytidine-tRNA cytidylyltransferase activity [GO:0052928]; CTP:tRNA cytidylyltransferase activity [GO:0052927]; tRNA binding [GO:0000049]; mitochondrial tRNA 3'-end processing [GO:1990180]; tRNA 3'-end processing [GO:0042780]; tRNA 3'-terminal CCA addition [GO:0001680]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96Q11-1; Sequence=Displayed; Name=2; IsoId=Q96Q11-2; Sequence=VSP_008442; Name=3; IsoId=Q96Q11-3; Sequence=VSP_008440, VSP_008441; Note=No experimental confirmation available.; 


uniprotID: Q12816
geneSymbol: TRO
name: Trophinin (MAGE-D3 antigen)
length: 1431
go: ENSG00000067445;
snps: rs60674633 rs17297490
sequence:

opentargets:
intrinsic component of plasma membrane [GO:0031226]; embryo implantation [GO:0007566]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q12816-1; Sequence=Displayed; Name=2; IsoId=Q12816-2; Sequence=VSP_043513, VSP_043514; Note=No experimental confirmation available.; Name=3; IsoId=Q12816-3; Sequence=VSP_053937; Name=4; IsoId=Q12816-4; Sequence=VSP_053938; Name=5; IsoId=Q12816-5; Sequence=VSP_053938, VSP_043513, VSP_043514; 


uniprotID: O75762
geneSymbol: TRPA1
reactome: R-HSA-3295583;
pdb: 3J9P;
length: 1119
go: ENSG00000104321;
drug: DB00825;
snps: rs13268757 rs16937976 rs920829 rs7819749 rs398123010 rs959976
name:
Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation-sensitive protein p120)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; stereocilium bundle [GO:0032421]; calcium channel activity [GO:0005262]; calcium-release channel activity [GO:0015278]; channel activity [GO:0015267]; identical protein binding [GO:0042802]; temperature-gated cation channel activity [GO:0097604]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; ion transport [GO:0006811]; protein homotetramerization [GO:0051289]; response to cold [GO:0009409]; response to hydrogen peroxide [GO:0042542]; response to organic cyclic compound [GO:0014070]; response to organic substance [GO:0010033]; response to pain [GO:0048265]; sensory perception of pain [GO:0019233]; thermoception [GO:0050955]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20547126, ECO:0000269|PubMed:25389312, ECO:0000269|PubMed:25855297}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q9BVK8
geneSymbol: TMEM147
name: Transmembrane protein 147 (Protein NIFIE 14)
length: 224
go: ENSG00000105677;
snps: rs1269215
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; protein-containing complex [GO:0032991]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BVK8-1; Sequence=Displayed; Name=2; IsoId=Q9BVK8-2; Sequence=VSP_047210; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20538592}; Multi-pass membrane protein {ECO:0000269|PubMed:20538592}.


uniprotID: Q9BTX3
geneSymbol: TMEM208
name: Transmembrane protein 208
length: 173
go: ENSG00000168701;
snps: rs17851038 rs11553801
sequence:
MAPKGKVGTRGKKQIFEENRETLKFYLRIILGANAIYCLVTLVFFYSSASFWAWLALGFSLAVYGASYHSMSSMARAAFSEDGALMDGGMDLNMEQGMAEHLKDVILLTAIVQVLSCFSLYVWSFWLLAPGRALYLLWVNVLGPWFTADSGTPAPEHNEKRQRRQERRQMKRL

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; vacuole [GO:0005773]; autophagy [GO:0006914]; vacuolar protein processing [GO:0006624]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BTX3-1; Sequence=Displayed; Name=2; IsoId=Q9BTX3-2; Sequence=VSP_032505; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23691174}; Multi-pass membrane protein {ECO:0000269|PubMed:23691174}.


uniprotID: Q7Z5M5
geneSymbol: TMC3
name: Transmembrane channel-like protein 3
length: 1100
go: ENSG00000188869;
snps: rs7497202 rs11636318 rs8031046 rs4417518
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; ion channel activity [GO:0005216]; mechanosensitive ion channel activity [GO:0008381]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:12812529}; IsoId=Q7Z5M5-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12906855}; IsoId=Q7Z5M5-2; Sequence=VSP_052201, VSP_052202; 


uniprotID: Q9UHF0
geneSymbol: TAC3
reactome: R-HSA-380095;R-HSA-416476;
pdb: 1P9F;
name: Tachykinin-3 (ZNEUROK1) [Cleaved into: Neurokinin-B (NKB) (Neuromedin-K)]
length: 121
go: ENSG00000166863;
snps: rs727505372 rs121918123
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MRIMLLFTAILAFSLAQSFGAVCKEPQEEVVPGGGRSKRDPDLYQLLQRLFKSHSSLEGLLKALSQASTDPKESTSPEKRDMHDFFVGLMGKRSVQPDSPTDVNQENVPSFGILKYPPRAE

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuromedin K receptor binding [GO:0031836]; signaling receptor binding [GO:0005102]; substance K receptor binding [GO:0031837]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of flagellated sperm motility [GO:1902093]; tachykinin receptor signaling pathway [GO:0007217]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Beta tachykinin 3; IsoId=Q9UHF0-1; Sequence=Displayed; Name=2; Synonyms=Alpha tachykinin 3; IsoId=Q9UHF0-2; Sequence=VSP_013187; Name=3; Synonyms=Gamma tachykinin 3; IsoId=Q9UHF0-3; Sequence=VSP_013186; 


uniprotID: Q9BSA9
geneSymbol: TMEM175
name: Endosomal/lysosomal potassium channel TMEM175 (Transmembrane protein 175) (hTMEM175)
length: 504
go: ENSG00000127419;
snps: rs34884217 rs34311866
sequence:

opentargets:
endosome [GO:0005768]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; potassium channel activity [GO:0005267]; potassium ion leak channel activity [GO:0022841]; phagosome-lysosome fusion [GO:0090385]; potassium ion transmembrane transport [GO:0071805]; regulation of lysosomal lumen pH [GO:0035751]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BSA9-1; Sequence=Displayed; Name=2; IsoId=Q9BSA9-2; Sequence=VSP_024213; 

location:
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:26317472}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:26317472}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q92545
geneSymbol: TMEM131
name: Transmembrane protein 131 (Protein RW1)
length: 1883
go: ENSG00000075568;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: O75069
geneSymbol: TMCC2
name: Transmembrane and coiled-coil domains protein 2 (Cerebral protein 11)
length: 709
go: ENSG00000133069;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; amyloid precursor protein metabolic process [GO:0042982]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=O75069-1; Sequence=Displayed; Name=2; IsoId=O75069-2; Sequence=VSP_046245; Note=No experimental confirmation available.; Name=3; IsoId=O75069-3; Sequence=VSP_058939; Name=4; IsoId=O75069-4; Sequence=VSP_058938, VSP_058941, VSP_058942; Name=5; IsoId=O75069-5; Sequence=VSP_058940; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:21593558}.


uniprotID: Q9BU79
geneSymbol: TMEM243
name: Transmembrane protein 243 (MDR1- and mitochondrial taxol resistance-associated protein) (MM-TRAG)
length: 118
go: ENSG00000135185;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MEDFATRTYGTSGLDNRPLFGETSAKDRIINLVVGSLTSLLILVTLISAFVFPQLPPKPLNIFFAVCISLSSITACILIYWYRQGDLEPKFRKLIYYIIFSIIMLCICANLYFHDVGR


uniprotID: Q4W5P6
geneSymbol: TMEM155
name: Protein TMEM155
length: 130
go: ENSG00000164112;
opentargets: extracellular region [GO:0005576]
snps: rs4370153
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MASDLIRTILAVALISKLGTAVDAELMPSGAILQNKRENLPRVCHALAFLGMARCQDLFLVRLQGWKLGTRFQDGPRSTPQEEGGSPQRKRGMPVQIHFLLKSFLSSPITFAFISLARTVSLATAICKIV


uniprotID: Q6PI78
geneSymbol: TMEM65
name: Transmembrane protein 65
length: 240
go: ENSG00000164983;
snps: rs17854113
sequence:

opentargets:
integral component of membrane [GO:0016021]; intercalated disc [GO:0014704]; mitochondrial inner membrane [GO:0005743]; plasma membrane [GO:0005886]; cardiac ventricle development [GO:0003231]; regulation of cardiac conduction [GO:1903779]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26403541}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:24765583, ECO:0000269|PubMed:28295037}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at the intercalated disk in the ventricular tissue (PubMed:26403541). {ECO:0000269|PubMed:26403541}.


uniprotID: Q7Z6W1
geneSymbol: TMCO2
name: Transmembrane and coiled-coil domain-containing protein 2
length: 182
go: ENSG00000188800;
opentargets: integral component of membrane [GO:0016021]; nucleus [GO:0005634]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
MSTSSSSSWDNLLESLSLSTVWNWIQASFLGETSAPQQTSLGLLDNLAPAVQIILRISFLILLGIGIYALWKRSIQSIQKTLLFVITLYKLYKKGSHIFEALLANPEGSGLRIQDNNNLFLSLGLQEKILKKLKTVENKMKNLEGIIVAQKPATKRDCSSEPYCSCSDCQSPLSTSGFTSPI


uniprotID: Q96EY4
geneSymbol: TMA16
name: Translation machinery-associated protein 16
length: 203
go: ENSG00000198498;
opentargets: nucleolus [GO:0005730]; nucleus [GO:0005634]
snps: rs34907234 rs2304802 rs1561736
sequence:


uniprotID: Q86V40
geneSymbol: TRABD2A
name: Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A)
length: 505
go: ENSG00000186854;
snps: rs1863772 rs2288352 rs1649292
sequence:

opentargets:
integral component of organelle membrane [GO:0031301]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; endopeptidase activity [GO:0004175]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147]; head development [GO:0060322]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of protein oxidation [GO:1904808]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86V40-1; Sequence=Displayed; Name=2; IsoId=Q86V40-2; Sequence=VSP_038837; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.


uniprotID: Q8IVF5
geneSymbol: TIAM2
reactome: R-HSA-193648;R-HSA-194840;R-HSA-1989781;R-HSA-416482;
name: T-lymphoma invasion and metastasis-inducing protein 2 (TIAM-2) (SIF and TIAM1-like exchange factor)
length: 1701
go: ENSG00000146426;
snps: rs931312 rs7770537 rs4259257 rs11751128 rs1571767
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; regulation of lipid metabolic process [GO:0019216]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8IVF5-1; Sequence=Displayed; Name=2; IsoId=Q8IVF5-2; Sequence=VSP_030975; Name=3; Synonyms=Short; IsoId=Q8IVF5-3; Sequence=VSP_030971; Name=4; IsoId=Q8IVF5-4; Sequence=VSP_030972; Name=5; Synonyms=Long; IsoId=Q8IVF5-5; Sequence=VSP_030974; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone. Note=Localizes to the plasma membrane in neurites. {ECO:0000250}.


uniprotID: Q9NX00
geneSymbol: TMEM160
name: Transmembrane protein 160
length: 188
go: ENSG00000130748;
opentargets: integral component of membrane [GO:0016021]
snps: rs11083857
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MGGGWWWARAARLARLRFRRSLLPPQRPRSGGARGSFAPGHGPRAGASPPPVSELDRADAWLLRKAHETAFLSWFRNGLLASGIGVISFMQSDMGREAAYGFFLLGGLCVVWGSASYAVGLAALRGPMQLTLGGAAVGAGAVLAASLLWACAVGLYMGQLELDVELVPEDDGTASAEGPDEAGRPPPE


uniprotID: O95271
geneSymbol: TNKS
reactome: R-HSA-201681;R-HSA-4641257;R-HSA-5545619;R-HSA-5689880;R-HSA-8948751;
length: 1327
go: ENSG00000173273;
pdb:
2RF5;3UDD;3UH2;3UH4;4DVI;4I9I;4K4E;4K4F;4KRS;4LI6;4LI7;4LI8;4MSG;4MSK;4MT9;4N3R;4N4V;4OA7;4TOR;4TOS;4U6A;4UUH;4UW1;4W5S;4W6E;5EBT;5ECE;5ETY;5GP7;5JHQ;5JTI;5JU5;5KNI;

name:
Tankyrase-1 (TANK1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I)

sequence:

opentargets:
chromosome, centromeric region [GO:0000775]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear chromosome, telomeric region [GO:0000784]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; histone binding [GO:0042393]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; zinc ion binding [GO:0008270]; cell division [GO:0051301]; cellular response to nutrient [GO:0031670]; mitotic spindle organization [GO:0007052]; mRNA transport [GO:0051028]; negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric [GO:1904908]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; negative regulation of telomeric DNA binding [GO:1904743]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein poly-ADP-ribosylation [GO:0070212]; protein polyubiquitination [GO:0000209]; protein transport [GO:0015031]; regulation of telomere maintenance via telomerase [GO:0032210]; spindle assembly [GO:0051225]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95271-1; Sequence=Displayed; Name=2; IsoId=O95271-2; Sequence=VSP_004538, VSP_004539; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Chromosome, centromere. Nucleus, nuclear pore complex. Chromosome, telomere {ECO:0000305}. Cytoplasm, cytoskeleton, spindle pole. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. Localizes to spindle poles at mitosis onset via interaction with NUMA1.


uniprotID: Q9P0T7
geneSymbol: TMEM9
name: Transmembrane protein 9 (Dermal papilla-derived protein 4)
length: 183
go: ENSG00000116857;
sequence:
MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS

opentargets:
integral component of membrane [GO:0016021]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:12359240}; Single-pass type I membrane protein {ECO:0000269|PubMed:12359240}. Lysosome membrane {ECO:0000269|PubMed:12359240}; Single-pass type I membrane protein {ECO:0000269|PubMed:12359240}.


uniprotID: Q9NWH2
geneSymbol: TMEM242
name: Transmembrane protein 242
length: 141
go: ENSG00000215712;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
METAGAATGQPASGLEAPGSTNDRLFLVKGGIFLGTVAAAGMLAGFITTLSLAKKKSPEWFNKGSMATAALPESGSSLALRALGWGSLYAWCGVGVISFAVWKALGVHSMNDFRSKMQSIFPTIPKNSESAVEWEETLKSK


uniprotID: Q92973
geneSymbol: TNPO1
reactome: R-HSA-450513;R-HSA-5620924;
pdb: 1QBK;2H4M;2OT8;2QMR;2Z5J;2Z5K;2Z5M;2Z5N;2Z5O;4FDD;4FQ3;4JLQ;4OO6;5J3V;5TQC;5YVG;5YVH;5YVI;
name: Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)
length: 898
go: ENSG00000083312;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nucleus [GO:0005634]; nuclear localization sequence binding [GO:0008139]; Ran GTPase binding [GO:0008536]; RNA binding [GO:0003723]; intraciliary transport involved in cilium assembly [GO:0035735]; NLS-bearing protein import into nucleus [GO:0006607]; protein import into nucleus, translocation [GO:0000060]; regulation of mRNA stability [GO:0043488]; ribosomal protein import into nucleus [GO:0006610]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q92973-1; Sequence=Displayed; Name=2; IsoId=Q92973-2; Sequence=VSP_038028; Name=3; IsoId=Q92973-3; Sequence=VSP_038029; 


uniprotID: Q2WGJ8
geneSymbol: TMEM249
name: Transmembrane protein 249
length: 235
go: ENSG00000261587;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9BZW4
geneSymbol: TM6SF2
name: Transmembrane 6 superfamily member 2
length: 377
go: ENSG00000213996;
snps: rs58542926
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; integral component of membrane [GO:0016021]; lipid metabolic process [GO:0006629]; regulation of lipid metabolic process [GO:0019216]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BZW4-1; Sequence=Displayed; Name=2; IsoId=Q9BZW4-2; Sequence=VSP_040282; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:25566323}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q8TC26
geneSymbol: TMEM163
name: Transmembrane protein 163
length: 289
go: ENSG00000152128;
sequence:

opentargets:
cell junction [GO:0030054]; early endosome membrane [GO:0031901]; integral component of synaptic vesicle membrane [GO:0030285]; zinc ion binding [GO:0008270]; zinc ion import into synaptic vesicle [GO:0099180]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TC26-1; Sequence=Displayed; Name=2; IsoId=Q8TC26-2; Sequence=VSP_023329, VSP_023330, VSP_023331, VSP_023332; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q8TC26-3; Sequence=VSP_023328; Note=No experimental confirmation available. Dubious isoform that could be a cloning artifact.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Early endosome membrane {ECO:0000250}. Note=Glutamatergic synaptic vesicles. {ECO:0000250}.


uniprotID: A5PLL7
geneSymbol: TMEM189
name: Transmembrane protein 189
length: 270
go: ENSG00000240849;
snps: rs2026757
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A5PLL7-1; Sequence=Displayed; Name=2; IsoId=A5PLL7-2; Sequence=VSP_054091; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11076860}; Multi-pass membrane protein {ECO:0000269|PubMed:11076860}.


uniprotID: Q53FP2
geneSymbol: TMEM35A
name: Transmembrane protein 35A
length: 167
go: ENSG00000126950;
sequence:
MASPRTVTIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKPLPGNAEEQPSLYEKAPQGKVKVS

opentargets:
cytoplasmic vesicle [GO:0031410]; integral component of membrane [GO:0016021]; peroxisomal membrane [GO:0005778]

location:
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Shedding may lead to a soluble peptide. {ECO:0000250}.


uniprotID: Q9NQ88
geneSymbol: TIGAR
reactome: R-HSA-5628897;
pdb: 3DCY;
length: 270
go: ENSG00000078237;
name:
Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular [GO:0005622]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; bisphosphoglycerate 2-phosphatase activity [GO:0004083]; fructose-2,6-bisphosphate 2-phosphatase activity [GO:0004331]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; cellular response to cobalt ion [GO:0071279]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to hypoxia [GO:0071456]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 2,6-bisphosphate metabolic process [GO:0006003]; intestinal epithelial cell development [GO:0060576]; negative regulation of glucose catabolic process to lactate via pyruvate [GO:1904024]; negative regulation of glycolytic process [GO:0045820]; negative regulation of mitophagy [GO:1901525]; negative regulation of neuron death [GO:1901215]; negative regulation of programmed cell death [GO:0043069]; negative regulation of reactive oxygen species metabolic process [GO:2000378]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of DNA repair [GO:0045739]; positive regulation of hexokinase activity [GO:1903301]; regulation of pentose-phosphate shunt [GO:0043456]; regulation of response to DNA damage checkpoint signaling [GO:1902153]; response to gamma radiation [GO:0010332]; response to ischemia [GO:0002931]; response to xenobiotic stimulus [GO:0009410]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}. Nucleus {ECO:0000269|PubMed:25928429}. Mitochondrion {ECO:0000269|PubMed:23185017}. Note=Translocated to the mitochondria during hypoxia in a HIF1A-dependent manner (PubMed:23185017). Colocalizes with HK2 in the mitochondria during hypoxia (PubMed:23185017). Translocated to the nucleus during hypoxia and/or genome stress-induced DNA damage responses in cancer cells (PubMed:25928429). Translocation to the mitochondria is enhanced in ischemic cortex after reperfusion and/or during oxygen and glucose deprivation (OGD)/reoxygenation insult in primary neurons (By similarity). {ECO:0000250|UniProtKB:Q8BZA9, ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:25928429}.


uniprotID: A8MYB1
geneSymbol: TMCO5B
name: Transmembrane and coiled-coil domain-containing protein 5B
length: 307
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9BZW5
geneSymbol: TM6SF1
name: Transmembrane 6 superfamily member 1
length: 370
go: ENSG00000136404;
opentargets: integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]
snps: rs1062232 rs1989
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BZW5-1; Sequence=Displayed; Name=2; IsoId=Q9BZW5-2; Sequence=VSP_045697; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P58749}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q9BVT8
geneSymbol: TMUB1
length: 246
go: ENSG00000164897;
name:
Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS]

sequence:

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic membrane [GO:0045211]; recycling endosome [GO:0055037]; ubiquitin-dependent ERAD pathway [GO:0030433]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}.; SUBCELLULAR LOCATION: iHOPS: Cytoplasm {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments. XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest. {ECO:0000250|UniProtKB:Q9JMG3}.


uniprotID: Q6ZXV5
geneSymbol: TMTC3
name: Transmembrane and TPR repeat-containing protein 3 (Protein SMILE)
length: 915
go: ENSG00000139324;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; positive regulation of proteasomal protein catabolic process [GO:1901800]; response to endoplasmic reticulum stress [GO:0034976]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZXV5-1; Sequence=Displayed; Name=2; IsoId=Q6ZXV5-2; Sequence=VSP_023619; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:21603654}. Note=In odontoblast cultures, it colocalizes with PDIA3 in the endoplasmic reticulum. {ECO:0000269|PubMed:21603654}.


uniprotID: Q9NR96
geneSymbol: TLR9
reactome: R-HSA-109704;R-HSA-1679131;R-HSA-168138;R-HSA-975110;R-HSA-975138;R-HSA-975155;
name: Toll-like receptor 9 (CD antigen CD289)
length: 1032
go: ENSG00000239732;
drug: DB00608;DB01611;DB05463;DB05475;
snps: rs5743842 rs5743843 rs5743845 rs5743846 rs755472700 rs746622200
sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; interleukin-1 receptor binding [GO:0005149]; protein homodimerization activity [GO:0042803]; signaling pattern recognition receptor activity [GO:0008329]; siRNA binding [GO:0035197]; transmembrane signaling receptor activity [GO:0004888]; unmethylated CpG binding [GO:0045322]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to virus [GO:0051607]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; maintenance of gastrointestinal epithelium [GO:0030277]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of calcium-transporting ATPase activity [GO:1901895]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; positive regulation of B cell activation [GO:0050871]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of granulocyte macrophage colony-stimulating factor production [GO:0032725]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha biosynthetic process [GO:0045356]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of B cell differentiation [GO:0045577]; regulation of cytokine secretion [GO:0050707]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]; response to molecule of bacterial origin [GO:0002237]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]; tumor necrosis factor production [GO:0032640]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=A; IsoId=Q9NR96-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9NR96-2; Sequence=VSP_006520; Name=3; IsoId=Q9NR96-3; Sequence=VSP_006521; Name=4; IsoId=Q9NR96-4; Sequence=VSP_006522; Name=5; IsoId=Q9NR96-5; Sequence=VSP_006523; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EQU3}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9EQU3}. Endosome {ECO:0000250|UniProtKB:Q9EQU3}. Lysosome {ECO:0000250|UniProtKB:Q9EQU3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9EQU3}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Exit from the ER requires UNC93B1. Endolysosomal localization is required for proteolytic cleavage and subsequent activation. Intracellular localization of the active receptor may prevent from responding to self nucleic acid. {ECO:0000250|UniProtKB:Q9EQU3}.


uniprotID: A6NGB7
geneSymbol: TMEM221
name: Transmembrane protein 221
length: 291
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9NZQ9
geneSymbol: TMOD4
reactome: R-HSA-390522;
name: Tropomodulin-4 (Skeletal muscle tropomodulin) (Sk-Tmod)
length: 345
go: ENSG00000163157;
snps: rs11800088
sequence:

opentargets:
myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; actin filament binding [GO:0051015]; tropomyosin binding [GO:0005523]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NZQ9-1; Sequence=Displayed; Name=2; IsoId=Q9NZQ9-2; Sequence=VSP_056865; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}.


uniprotID: P25325
geneSymbol: MPST
reactome: R-HSA-1614558;
pdb: 3OLH;4JGT;
name: 3-mercaptopyruvate sulfurtransferase (MST) (EC 2.8.1.2)
length: 297
go: ENSG00000128309;
sequence:

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; neuron projection [GO:0043005]; synapse [GO:0045202]; 3-mercaptopyruvate sulfurtransferase activity [GO:0016784]; identical protein binding [GO:0042802]; thiosulfate sulfurtransferase activity [GO:0004792]; cyanate catabolic process [GO:0009440]; hydrogen sulfide biosynthetic process [GO:0070814]; kidney development [GO:0001822]; liver development [GO:0001889]; response to toxic substance [GO:0009636]; spinal cord development [GO:0021510]; sulfur amino acid catabolic process [GO:0000098]; transsulfuration [GO:0019346]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P25325-1; Sequence=Displayed; Name=2; IsoId=P25325-2; Sequence=VSP_055027; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97532}. Mitochondrion {ECO:0000250|UniProtKB:P97532}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q99J99}.


uniprotID: Q9H2L4
geneSymbol: TMEM60
name: Transmembrane protein 60
length: 133
go: ENSG00000135211;
opentargets: integral component of membrane [GO:0016021]
snps: rs34580932
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MRMSLAQRVLLTWLFTLLFLIMLVLKLDEKAPWNWFLIFIPVWIFDTILLVLLIVKMAGRCKSGFDPRHGSHNIKKKAWYLIAMLLKLAFCLALCAKLEQFTTMNLSYVFIPLWALLAGALTELGYNVFFVRD


uniprotID: Q8N394
geneSymbol: TMTC2
name: Transmembrane and TPR repeat-containing protein 2
length: 836
go: ENSG00000179104;
snps: rs1201791 rs17010106 rs428398
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; calcium ion homeostasis [GO:0055074]


uniprotID: Q8N6Q1
geneSymbol: TMCO5A
name: Transmembrane and coiled-coil domain-containing protein 5A
length: 288
go: ENSG00000166069;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N6Q1-1; Sequence=Displayed; Name=2; IsoId=Q8N6Q1-2; Sequence=VSP_028246, VSP_028247; Note=No experimental confirmation available.; 


uniprotID: Q92544
geneSymbol: TM9SF4
name: Transmembrane 9 superfamily member 4 (Tumor cannibalism associated protein 1)
length: 642
go: ENSG00000101337;
sequence:

opentargets:
early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; cell adhesion [GO:0007155]; phagocytosis [GO:0006909]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein localization to cell surface [GO:2000010]; protein localization to membrane [GO:0072657]; regulation of intracellular pH [GO:0051453]; response to hypoxia [GO:0001666]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000269|PubMed:25999474}. Early endosome {ECO:0000269|PubMed:19893578}.


uniprotID: Q8TB96
geneSymbol: ITFG1
length: 612
go: ENSG00000129636;
opentargets: extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]
name:
T-cell immunomodulatory protein (Protein TIP) (Integrin-alpha FG-GAP repeat-containing protein 1) (Linkin)

sequence:

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.


uniprotID: Q8N616
geneSymbol: LINC00311
name: Putative uncharacterized protein encoded by LINC00311
length: 119
sequence:
MVAADQGRGWNPLDGPTWEVLAMPLPLGPATQVPALFSAALVPPVSSLRPNQMLDWQRLKTPHGAPVACSLGLSGEWVPTPCALSILALLGLQLDPLFGLWGCTRTLFWSEWARESRRP


uniprotID: P35625
geneSymbol: TIMP3
reactome: R-HSA-114608;
pdb: 3CKI;
name: Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)
length: 211
go: ENSG00000100234;
drug: DB05383;
snps: rs137853300 rs137853301 rs137853299 rs137853298
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; platelet dense granule lumen [GO:0031089]; metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; cellular response to organic substance [GO:0071310]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metalloendopeptidase activity [GO:1904684]; platelet degranulation [GO:0002576]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to organic substance [GO:0010033]; visual perception [GO:0007601]


uniprotID: O14669
geneSymbol: PRRG2
length: 202
go: ENSG00000126460;
snps: rs35016366 rs2288920
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Transmembrane gamma-carboxyglutamic acid protein 2 (Proline-rich gamma-carboxyglutamic acid protein 2) (Proline-rich Gla protein 2)

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]


uniprotID: Q9H6L2
geneSymbol: TMEM231
name: Transmembrane protein 231
length: 316
go: ENSG00000205084;
snps: rs3743601 rs200799769 rs397514754
sequence:

opentargets:
ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; integral component of membrane [GO:0016021]; MKS complex [GO:0036038]; camera-type eye development [GO:0043010]; cilium assembly [GO:0060271]; embryonic digit morphogenesis [GO:0042733]; in utero embryonic development [GO:0001701]; neuroepithelial cell differentiation [GO:0060563]; regulation of protein localization [GO:0032880]; smoothened signaling pathway [GO:0007224]; vasculature development [GO:0001944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H6L2-1; Sequence=Displayed; Name=2; IsoId=Q9H6L2-2; Sequence=VSP_042388; Name=3; IsoId=Q9H6L2-3; Sequence=VSP_042387; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone. {ECO:0000250}.


uniprotID: Q9P0N5
geneSymbol: TMEM216
reactome: R-HSA-5620912;
name: Transmembrane protein 216
length: 145
go: ENSG00000187049;
snps: rs779526456 rs201108965 rs201108965 rs386833830 rs780098806 rs386833831
sequence:
MLPRGLKMAPRGKRLSSTPLEILFFLNGWYNATYFLLELFIFLYKGVLLPYPTANLVLDVVMLLLYLGIEVIRLFFGTKGNLCQRKMPLSISVALTFPSAMMASYYLLLQTYVLRLEAIMNGILLFFCGSELLLEVLTLAAFSRI

opentargets:
ciliary transition zone [GO:0035869]; cilium [GO:0005929]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; MKS complex [GO:0036038]; ciliary basal body-plasma membrane docking [GO:0097711]; cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9P0N5-1; Sequence=Displayed; Name=2; IsoId=Q9P0N5-2; Sequence=VSP_040295, VSP_040296; Name=3; IsoId=Q9P0N5-3; Sequence=VSP_040296; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22282472}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme.


uniprotID: A0A1W2PR48
geneSymbol: TLE7
name: Transducin-like enhancer protein 7
length: 441
opentargets: nucleus [GO:0005634]; regulation of transcription, DNA-templated [GO:0006355]
sequence:


uniprotID: P48788
geneSymbol: TNNI2
reactome: R-HSA-390522;
pdb: 2MKP;
name: Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
length: 182
go: ENSG00000130598;
snps: rs104894311
sequence:
MGDEEKRNRAITARRQHLKSVMLQIAATELEKEESRREAEKQNYLAEHCPPLHIPGSMSEVQELCKQLHAKIDAAEEEKYDMEVRVQKTSKELEDMNQKLFDLRGKFKRPPLRRVRMSADAMLKALLGSKHKVCMDLRANLKQVKKEDTEKERDLRDVGDWRKNIEEKSGMEGRKKMFESES

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; troponin complex [GO:0005861]; actin binding [GO:0003779]; troponin T binding [GO:0031014]; cardiac muscle contraction [GO:0060048]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of muscle contraction [GO:0006937]; skeletal muscle contraction [GO:0003009]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48788-1; Sequence=Displayed; Name=2; IsoId=P48788-2; Sequence=VSP_046052; Note=No experimental confirmation available.; 


uniprotID: Q7Z404
geneSymbol: TMC4
name: Transmembrane channel-like protein 4
length: 712
snps: rs641738 rs36657
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; ion channel activity [GO:0005216]; mechanosensitive ion channel activity [GO:0008381]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z404-2; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q7Z404-1; Sequence=VSP_026012; Name=3; IsoId=Q7Z404-3; Sequence=VSP_026011, VSP_026013; 


uniprotID: Q0VDI3
geneSymbol: TMEM267
name: Transmembrane protein 267
length: 215
go: ENSG00000151881;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: P19429
geneSymbol: TNNI3
reactome: R-HSA-390522;R-HSA-5578775;
pdb: 1J1D;1J1E;1LXF;1MXL;1OZS;2KGB;2KRD;2L1R;2MZP;2N7L;4Y99;5VLN;5W88;5WCL;
name: Troponin I, cardiac muscle (Cardiac troponin I)
length: 210
go: ENSG00000129991;
drug: DB04513;
sequence:

opentargets:
cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; troponin complex [GO:0005861]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; calcium channel inhibitor activity [GO:0019855]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; troponin C binding [GO:0030172]; troponin T binding [GO:0031014]; cardiac muscle contraction [GO:0060048]; cellular calcium ion homeostasis [GO:0006874]; heart contraction [GO:0060047]; heart development [GO:0007507]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; negative regulation of ATPase activity [GO:0032780]; regulation of cardiac muscle contraction by calcium ion signaling [GO:0010882]; regulation of smooth muscle contraction [GO:0006940]; regulation of systemic arterial blood pressure by ischemic conditions [GO:0001980]; skeletal muscle contraction [GO:0003009]; vasculogenesis [GO:0001570]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]

snps:
rs397516359 rs267607130 rs3729712 rs77615401 rs777177571 rs397516347 rs121917760 rs104894724 rs104894724 rs397516353 rs397516354 rs397516354 rs727504242 rs121917761 rs104894730 rs267607129 rs397516357 rs104894729 rs104894727 rs727504275 rs104894725 


uniprotID: Q17RP2
geneSymbol: TIGD6
name: Tigger transposable element-derived protein 6
length: 521
go: ENSG00000164296;
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]
snps: rs9324636 rs10875553
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9Y3B3
geneSymbol: TMED7
reactome: R-HSA-6807878;R-HSA-6811434;
name: Transmembrane emp24 domain-containing protein 7 (p24 family protein gamma-3) (p24gamma3) (p27)
length: 224
go: ENSG00000134970;ENSG00000251201;
sequence:

opentargets:
COPI vesicle coat [GO:0030126]; COPII vesicle coat [GO:0030127]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; transport vesicle [GO:0030133]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3B3-1; Sequence=Displayed; Name=2; IsoId=Q9Y3B3-2; Sequence=VSP_046247; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.


uniprotID: Q9NWC5
geneSymbol: TMEM45A
length: 275
go: ENSG00000181458;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Transmembrane protein 45A (DNA polymerase-transactivated protein 4) (Dermal papilla-derived protein 7)

sequence:


uniprotID: P19237
geneSymbol: TNNI1
reactome: R-HSA-390522;
name: Troponin I, slow skeletal muscle (Troponin I, slow-twitch isoform)
length: 187
go: ENSG00000159173;
snps: rs2296695
sequence:
MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDAAKSPTSQ

opentargets:
cytosol [GO:0005829]; troponin complex [GO:0005861]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of striated muscle contraction [GO:0006942]; transition between fast and slow fiber [GO:0014883]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]


uniprotID: Q66K66
geneSymbol: TMEM198
name: Transmembrane protein 198
length: 360
go: ENSG00000188760;
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; multicellular organism development [GO:0007275]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Largely located to vesicle-like structures. {ECO:0000250}.


uniprotID: P01266
geneSymbol: TG
name: Thyroglobulin (Tg)
length: 2768
go: ENSG00000042832;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular region [GO:0005576]; hormone activity [GO:0005179]; hormone biosynthetic process [GO:0042446]; iodide transport [GO:0015705]; regulation of myelination [GO:0031641]; signal transduction [GO:0007165]; thyroid gland development [GO:0030878]; thyroid hormone metabolic process [GO:0042403]

snps:
rs2069546 rs180222 rs2069547 rs2069548 rs180223 rs3739274 rs16904774 rs2076737 rs2229843 rs16893332 rs853326 rs143983705 rs1016185504 rs11992497 rs12549018 rs2076738 rs2069556 rs2069558 rs16904791 rs2069561 rs121912649 rs2069562 rs56230101 rs2076739 rs2076740 rs2069564 rs2069565 rs370991693 rs2069566 rs121912650 rs137854434 rs2272707 rs2069568 rs2069569 rs12114109 rs1133076 rs10091530 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Major; IsoId=P01266-1; Sequence=Displayed; Name=2; Synonyms=Minor; IsoId=P01266-2; Sequence=VSP_012655; 


uniprotID: Q6UWJ1
geneSymbol: TMCO3
name: Transmembrane and coiled-coil domain-containing protein 3 (Putative LAG1-interacting protein)
length: 677
go: ENSG00000150403;
opentargets: integral component of membrane [GO:0016021]; solute:proton antiporter activity [GO:0015299]
snps: rs185071949 rs2260335 rs7319493
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6UWJ1-1; Sequence=Displayed; Name=2; IsoId=Q6UWJ1-2; Sequence=VSP_020563, VSP_020564; Note=No experimental confirmation available.; Name=3; IsoId=Q6UWJ1-3; Sequence=VSP_020561, VSP_020562; Note=No experimental confirmation available.; 


uniprotID: Q9UKI8
geneSymbol: TLK1
name: Serine/threonine-protein kinase tousled-like 1 (EC 2.7.11.1) (PKU-beta) (Tousled-like kinase 1)
length: 766
go: ENSG00000198586;
sequence:

opentargets:
nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; chromatin organization [GO:0006325]; intracellular protein transport [GO:0006886]; intracellular signal transduction [GO:0035556]; protein phosphorylation [GO:0006468]; regulation of chromatin assembly or disassembly [GO:0001672]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1 {ECO:0000269|PubMed:10523312}; IsoId=Q9UKI8-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:9427565}; IsoId=Q9UKI8-2; Sequence=VSP_050571; Name=3 {ECO:0000269|PubMed:10588641}; Synonyms=SNAK {ECO:0000269|PubMed:10588641}, TLK1B; IsoId=Q9UKI8-3; Sequence=VSP_050570; Name=4; IsoId=Q9UKI8-4; Sequence=VSP_043505, VSP_043506; Note=No experimental confirmation available.; Name=5; IsoId=Q9UKI8-5; Sequence=VSP_043504; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523312, ECO:0000269|PubMed:10588641, ECO:0000269|PubMed:11314006, ECO:0000269|PubMed:9427565}.


uniprotID: O15164
geneSymbol: TRIM24
reactome: R-HSA-1839117;R-HSA-5655302;R-HSA-6802952;
pdb: 2YYN;3O33;3O34;3O35;3O36;3O37;4YAB;4YAD;4YAT;4YAX;4YBM;4YBS;4YBT;4YC9;4ZQL;5H1T;5H1U;5H1V;
length: 1050
go: ENSG00000122779;
snps: rs35356723 rs34585297
name:
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear euchromatin [GO:0005719]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; chromatin binding [GO:0003682]; estrogen response element binding [GO:0034056]; lysine-acetylated histone binding [GO:0070577]; nuclear receptor binding [GO:0016922]; p53 binding [GO:0002039]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; calcium ion homeostasis [GO:0055074]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein catabolic process [GO:0030163]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; regulation of protein stability [GO:0031647]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of vitamin D receptor signaling pathway [GO:0070562]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=O15164-1; Sequence=Displayed; Name=Short; IsoId=O15164-2; Sequence=VSP_005772; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21164480}. Cytoplasm {ECO:0000269|PubMed:21164480}. Note=Colocalizes with sites of active transcription. Detected both in nucleus and cytoplasm in some breast cancer samples. Predominantly nuclear.


uniprotID: O60235
geneSymbol: TMPRSS11D
length: 418
go: ENSG00000153802;
name:
Transmembrane protease serine 11D (EC 3.4.21.-) (Airway trypsin-like protease) [Cleaved into: Transmembrane protease serine 11D non-catalytic chain; Transmembrane protease serine 11D catalytic chain]

sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; peptidase activity [GO:0008233]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]; respiratory gaseous exchange [GO:0007585]

location:
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Note=Activated by cleavage and secreted.; SUBCELLULAR LOCATION: Transmembrane protease serine 11D catalytic chain: Secreted. Note=Activated by cleavage and secreted.


uniprotID: Q96GM8
geneSymbol: TOE1
pdb: 2FC6;
name: Target of EGR1 protein 1
length: 510
go: ENSG00000132773;
sequence:

opentargets:
Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; 3'-5'-exoribonuclease activity [GO:0000175]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; snRNA binding [GO:0017069]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; snRNA 3'-end processing [GO:0034472]

snps:
rs774056037 rs371848318 rs148067486 rs777030573 rs778263701 rs368182654 rs758153898 rs750266350 rs9429157 rs61323219 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GM8-1; Sequence=Displayed; Name=2; IsoId=Q96GM8-2; Sequence=VSP_055529; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12562764}. Nucleus speckle {ECO:0000269|PubMed:12562764}. Note=Localizes to nuclear speckles.


uniprotID: A0A5B9
geneSymbol: TRBC2
name: T cell receptor beta constant 2
length: 178
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
pdb:
1AO7;1BD2;2EYR;2EYS;2EYT;3KXF;3O6F;3O8X;3O9W;3QUX;3T0E;3TA3;3TVM;4C56;4MVB;4MXQ;4N0C;4N5E;4NHU;4ONH;4P4K;4UDT;4UDU;4WW1;4WW2;4WWK;4Y16;4Y2D;4Y4F;4Y4H;4Y4K;4ZAK;5BRZ;5BS0;5C07;5C08;5C09;5C0A;5C0B;5C0C;5EU6;5FK9;5FKA;5HHM;5HHO;5HYJ;5KS9;5KSA;5KSB;6CPH;6CQL;6CQQ;6CQR;

sequence:
DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG

opentargets:
external side of plasma membrane [GO:0009897]; immunoglobulin complex, circulating [GO:0042571]; integral component of membrane [GO:0016021]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of B cell activation [GO:0050871]


uniprotID: Q9UKU6
geneSymbol: TRHDE
length: 1024
go: ENSG00000072657;
location: SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
name:
Thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) (TRH-degrading ectoenzyme) (EC 3.4.19.6) (Pyroglutamyl-peptidase II) (PAP-II) (TRH-specific aminopeptidase) (Thyroliberinase)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; metalloaminopeptidase activity [GO:0070006]; peptide binding [GO:0042277]; zinc ion binding [GO:0008270]; cell-cell signaling [GO:0007267]; peptide catabolic process [GO:0043171]; proteolysis [GO:0006508]; signal transduction [GO:0007165]


uniprotID: Q96RU7
geneSymbol: TRIB3
reactome: R-HSA-1257604;R-HSA-165158;R-HSA-1989781;R-HSA-199418;R-HSA-389357;R-HSA-5218920;
length: 358
go: ENSG00000101255;
snps: rs757496714 rs2295490 rs35051116 rs56291463 rs56342286
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22977230}.
name:
Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)

sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase binding [GO:0019901]; protein kinase inhibitor activity [GO:0004860]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]; cellular response to insulin stimulus [GO:0032869]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein phosphorylation [GO:0006468]; regulation of glucose transmembrane transport [GO:0010827]; regulation of lipid metabolic process [GO:0019216]; regulation of MAP kinase activity [GO:0043405]; response to endoplasmic reticulum stress [GO:0034976]


uniprotID: Q8IZ69
geneSymbol: TRMT2A
name: tRNA (uracil-5-)-methyltransferase homolog A (EC 2.1.1.-) (HpaII tiny fragments locus 9c protein)
length: 625
go: ENSG00000099899;
opentargets: RNA binding [GO:0003723]; RNA methyltransferase activity [GO:0008173]; RNA processing [GO:0006396]
snps: rs447017
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IZ69-1; Sequence=Displayed; Name=2; IsoId=Q8IZ69-2; Sequence=VSP_011322, VSP_011323; Note=No experimental confirmation available.; 


uniprotID: Q9H8W5
geneSymbol: TRIM45
reactome: R-HSA-877300;
pdb: 2DS4;
name: Tripartite motif-containing protein 45 (RING finger protein 99)
length: 580
go: ENSG00000134253;
snps: rs34863850 rs749902 rs3738413 rs1289658
sequence:

opentargets:
cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; zinc ion binding [GO:0008270]; bone development [GO:0060348]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H8W5-1; Sequence=Displayed; Name=2; IsoId=Q9H8W5-2; Sequence=VSP_012000; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15351693}. Nucleus {ECO:0000269|PubMed:15351693}.


uniprotID: P0CF51
geneSymbol: TRGC1
pdb: 4LFH;4LHU;
name: T-cell receptor gamma chain C region 1
length: 173
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
DKQLDADVSPKPTIFLPSIAETKLQKAGTYLCLLEKFFPDVIKIHWQEKKSNTILGSQEGNTMKTNDTYMKFSWLTVPEKSLDKEHRCIVRHENNKNGVDQEIIFPPIKTDVITMDPKDNCSKDANDTLLLQLTNTSAYYMYLLLLLKSVVYFAIITCCLLRRTAFCCNGEKS


uniprotID: Q96B42
geneSymbol: TMEM18
name: Transmembrane protein 18
length: 140
go: ENSG00000151353;
sequence:
MPSAFSVSSFPVSIPAVLTQTDWTEPWLMGLATFHALCVLLTCLSSRSYRLQIGHFLCLVILVYCAEYINEAAAMNWRLFSKYQYFDSRGMFISIVFSAPLLVNAMIIVVMWVWKTLNVMTDLKNAQERRKEKKRRRKED

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; nuclear membrane [GO:0031965]; DNA binding [GO:0003677]; cell migration [GO:0016477]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96B42-1; Sequence=Displayed; Name=2; IsoId=Q96B42-2; Sequence=VSP_024469; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}. Nucleus membrane {ECO:0000269|PubMed:18559506, ECO:0000269|PubMed:21980424}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q13009
geneSymbol: TIAM1
reactome: R-HSA-193648;R-HSA-194840;R-HSA-3928662;R-HSA-3928665;R-HSA-416482;R-HSA-9032845;
pdb: 2D8I;3KZD;3KZE;4GVC;4GVD;4K2O;4K2P;4NXP;4NXQ;4NXR;
name: T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1)
length: 1591
go: ENSG00000156299;
snps: rs2070418 rs2070417 rs16987932 rs77092908 rs75483199
sequence:

opentargets:
axonal growth cone [GO:0044295]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; extrinsic component of postsynaptic density membrane [GO:0099147]; glutamatergic synapse [GO:0098978]; main axon [GO:0044304]; microtubule [GO:0005874]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; kinase binding [GO:0019900]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; Rac guanyl-nucleotide exchange factor activity [GO:0030676]; receptor tyrosine kinase binding [GO:0030971]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; activation of GTPase activity [GO:0090630]; apoptotic process [GO:0006915]; cardiac muscle hypertrophy [GO:0003300]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled receptor signaling pathway [GO:0007186]; neuron projection extension [GO:1990138]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; positive regulation of apoptotic process [GO:0043065]; positive regulation of axonogenesis [GO:0050772]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of protein binding [GO:0032092]; positive regulation of Schwann cell chemotaxis [GO:1904268]; protein localization to membrane [GO:0072657]; Rac protein signal transduction [GO:0016601]; regulation of dopaminergic neuron differentiation [GO:1904338]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; regulation of modification of postsynaptic actin cytoskeleton [GO:1905274]; regulation of non-canonical Wnt signaling pathway [GO:2000050]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to cocaine [GO:0042220]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13009-1; Sequence=Displayed; Name=2; IsoId=Q13009-2; Sequence=VSP_055865, VSP_055866; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction. {ECO:0000250}.


uniprotID: Q9UK28
geneSymbol: TMEM59L
name: Transmembrane protein 59-like (Brain-specific membrane-anchored protein)
length: 342
go: ENSG00000105696;
opentargets: Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; membrane [GO:0016020]
sequence:

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:20427278}; Single-pass type I membrane protein {ECO:0000305|PubMed:20427278}.


uniprotID: Q3KNT9
geneSymbol: TMEM95
name: Transmembrane protein 95
length: 176
go: ENSG00000182896;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MWRLALGGVFLAAAQACVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKLPEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGAFLLLGVLSLLVESHHLQAKSGL

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q3KNT9-1; Sequence=Displayed; Name=2; IsoId=Q3KNT9-2; Sequence=VSP_025245; Note=No experimental confirmation available.; Name=3; IsoId=Q3KNT9-3; Sequence=VSP_025246; Note=No experimental confirmation available.; 


uniprotID: Q9H813
geneSymbol: TMEM206
name: Transmembrane protein 206
length: 350
go: ENSG00000065600;
opentargets: cell surface [GO:0009986]; integral component of membrane [GO:0016021]
snps: rs1034429230
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H813-1; Sequence=Displayed; Name=2; IsoId=Q9H813-2; Sequence=VSP_042887; Note=No experimental confirmation available.; 


uniprotID: Q9P0S9
geneSymbol: TMEM14C
pdb: 2LOS;
name: Transmembrane protein 14C
length: 112
go: ENSG00000111843;
snps: rs1045961 rs1045964 rs1045967 rs1045986
sequence:
MQDTGSVVPLHWFGFGYAALVASGGIIGYVKAGSVPSLAAGLLFGSLAGLGAYQLSQDPRNVWVFLATSGTLAGIMGMRFYHSGKFMPAGLIAGASLLMVAKVGVSMFNRPH

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; erythrocyte differentiation [GO:0030218]; heme biosynthetic process [GO:0006783]; mitochondrial transport [GO:0006839]; regulation of heme biosynthetic process [GO:0070453]


uniprotID: P04216
geneSymbol: THY1
reactome: R-HSA-163125;
name: Thy-1 membrane glycoprotein (CDw90) (Thy-1 antigen) (CD antigen CD90)
length: 161
go: ENSG00000154096;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
sequence:
MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNVTVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMSL

opentargets:
anchored component of external side of plasma membrane [GO:0031362]; apical plasma membrane [GO:0016324]; axolemma [GO:0030673]; cell surface [GO:0009986]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendrite membrane [GO:0032590]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; myelin sheath [GO:0043209]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; GPI anchor binding [GO:0034235]; GTPase activator activity [GO:0005096]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; angiogenesis [GO:0001525]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cytoskeleton organization [GO:0007010]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell migration [GO:0030336]; negative regulation of neuron projection regeneration [GO:0070571]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of T cell receptor signaling pathway [GO:0050860]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell activation [GO:0050870]; protein autophosphorylation [GO:0046777]; receptor clustering [GO:0043113]; regulation of cell-matrix adhesion [GO:0001952]; regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000298]; retinal cone cell development [GO:0046549]; T cell receptor signaling pathway [GO:0050852]


uniprotID: Q86UU9
geneSymbol: TAC4
pdb: 2MOC;
length: 113
go: ENSG00000176358;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Tachykinin-4 (Preprotachykinin-C) (PPT-C) [Cleaved into: Endokinin-A (EKA); Endokinin-A/B (EKA/B); Endokinin-C (EKC)]

sequence:
MLPCLALLLLMELSVCTVAGDGGEEQTLSTEAETWVIVALEEGAGPSIQLQLQEVKTGKASQFFGLMGKRVGGRPLIQPRRKKAYQLEHTFQGLLGKRSLFTEGREDEAQGSE

opentargets:
cell [GO:0005623]; extracellular space [GO:0005615]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; substance K receptor binding [GO:0031837]; substance P receptor binding [GO:0031835]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; inflammatory response [GO:0006954]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of systemic arterial blood pressure [GO:0003085]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of sensory perception of pain [GO:1904058]; regulation of blood pressure [GO:0008217]; regulation of sensory perception of pain [GO:0051930]; tachykinin receptor signaling pathway [GO:0007217]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1 {ECO:0000269|PubMed:12716968}; Synonyms=Alpha {ECO:0000269|PubMed:12716968}; IsoId=Q86UU9-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12716968}; Synonyms=Beta {ECO:0000269|PubMed:12716968}; IsoId=Q86UU9-2; Sequence=VSP_052676, VSP_052677; Name=3 {ECO:0000269|PubMed:12716968}; Synonyms=Gamma {ECO:0000269|PubMed:12716968}; IsoId=Q86UU9-3; Sequence=VSP_052676, VSP_052681; Name=4 {ECO:0000269|PubMed:12716968}; Synonyms=Delta {ECO:0000269|PubMed:12716968}; IsoId=Q86UU9-4; Sequence=VSP_052676, VSP_052680; Name=5; IsoId=Q86UU9-5; Sequence=VSP_052676; 


uniprotID: O15393
geneSymbol: TMPRSS2
length: 492
go: ENSG00000184012;
snps: rs12329760 rs775137340 rs1056602 rs779875214
name:
Transmembrane protease serine 2 (EC 3.4.21.-) (Serine protease 10) [Cleaved into: Transmembrane protease serine 2 non-catalytic chain; Transmembrane protease serine 2 catalytic chain]

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; scavenger receptor activity [GO:0005044]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; positive regulation of viral entry into host cell [GO:0046598]; protein autoprocessing [GO:0016540]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15393-1; Sequence=Displayed; Name=2; IsoId=O15393-2; Sequence=VSP_045083; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}; Single-pass type II membrane protein {ECO:0000269|PubMed:20382709, ECO:0000269|PubMed:21068237}.; SUBCELLULAR LOCATION: Transmembrane protease serine 2 catalytic chain: Secreted {ECO:0000269|PubMed:20382709}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:20382709}.


uniprotID: Q9NRS4
geneSymbol: TMPRSS4
length: 437
go: ENSG00000137648;
snps: rs1894176 rs12270001 rs1941635
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
name:
Transmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; secretory granule [GO:0030141]; scavenger receptor activity [GO:0005044]; serine-type endopeptidase activity [GO:0004252]; negative regulation of growth rate [GO:0045967]; proteolysis [GO:0006508]; regulation of gene expression [GO:0010468]; response to wounding [GO:0009611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9NRS4-1; Sequence=Displayed; Name=2; IsoId=Q9NRS4-2; Sequence=VSP_013117; Note=No experimental confirmation available.; Name=3; IsoId=Q9NRS4-3; Sequence=VSP_013116; Note=No experimental confirmation available.; Name=4; IsoId=Q9NRS4-4; Sequence=VSP_013116, VSP_054229; Note=No experimental confirmation available.; 


uniprotID: Q9NWD8
geneSymbol: TMEM248
name: Transmembrane protein 248
length: 314
go: ENSG00000106609;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NWD8-1; Sequence=Displayed; Name=2; IsoId=Q9NWD8-2; Sequence=VSP_026736, VSP_026737; Note=No experimental confirmation available.; 


uniprotID: Q96KP6
geneSymbol: TNIP3
reactome: R-HSA-5689896;
length: 325
go: ENSG00000050730;
snps: rs10000692
name:
TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein)

sequence:

opentargets:
cytosol [GO:0005829]; polyubiquitin modification-dependent protein binding [GO:0031593]; cellular response to lipopolysaccharide [GO:0071222]; inflammatory response [GO:0006954]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; protein deubiquitination [GO:0016579]; toll-like receptor 4 signaling pathway [GO:0034142]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96KP6-1; Sequence=Displayed; Name=2; IsoId=Q96KP6-2; Sequence=VSP_045101, VSP_045103; Name=3; IsoId=Q96KP6-3; Sequence=VSP_045102, VSP_045103; 


uniprotID: Q9HC07
geneSymbol: TMEM165
name: Transmembrane protein 165 (Transmembrane protein PT27) (Transmembrane protein TPARL)
length: 324
go: ENSG00000134851;
snps: rs387907222 rs387907221 rs886037631
sequence:

opentargets:
early endosome membrane [GO:0031901]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; cellular calcium ion homeostasis [GO:0006874]; Golgi calcium ion transport [GO:0032472]; protein N-linked glycosylation [GO:0006487]; regulation of lysosomal lumen pH [GO:0035751]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HC07-1; Sequence=Displayed; Name=2; IsoId=Q9HC07-2; Sequence=VSP_056691; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane. Lysosome membrane. Early endosome membrane. Late endosome membrane.


uniprotID: O43615
geneSymbol: TIMM44
reactome: R-HSA-1268020;
pdb: 2CW9;
name: Mitochondrial import inner membrane translocase subunit TIM44
length: 452
go: ENSG00000104980;
sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10339406}; Peripheral membrane protein {ECO:0000269|PubMed:10339406}; Matrix side {ECO:0000269|PubMed:10339406}. Mitochondrion matrix {ECO:0000269|PubMed:10339406}.


uniprotID: Q96CG3
geneSymbol: TIFA
pdb: 4YM4;4ZGI;
length: 184
go: ENSG00000145365;
snps: rs6834237
name:
TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)

sequence:
MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTFQDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFGEYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMDENES

opentargets:
cytoplasm [GO:0005737]; cytoplasmic pattern recognition receptor signaling pathway [GO:0002753]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; innate immune response [GO:0045087]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; protein homooligomerization [GO:0051260]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22566686, ECO:0000305|PubMed:26068852}. Note=Colocalizes with lysosomal marker LAMP2 following homooligomerization and subsequent activation. {ECO:0000269|PubMed:26068852}.


uniprotID: Q6UXF1
geneSymbol: TMEM108
name: Transmembrane protein 108 (Retrolinkin)
length: 575
go: ENSG00000144868;
snps: rs34111099
sequence:

opentargets:
axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell junction [GO:0030054]; dendrite [GO:0030425]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; somatodendritic compartment [GO:0036477]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; dendrite extension [GO:0097484]; dentate gyrus development [GO:0021542]; modulation of excitatory postsynaptic potential [GO:0098815]; neuron projection development [GO:0031175]; positive regulation of neurotrophin TRK receptor signaling pathway [GO:0051388]; postsynaptic density organization [GO:0097106]; receptor-mediated endocytosis [GO:0006898]; retrograde axonal transport [GO:0008090]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6UXF1-1; Sequence=Displayed; Name=2; IsoId=Q6UXF1-2; Sequence=VSP_019494, VSP_019495; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8BHE4}; Multi-pass membrane protein {ECO:0000255}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q8BHE4}. Endosome membrane {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHE4}. Early endosome {ECO:0000250|UniProtKB:Q8BHE4}.


uniprotID: O94876
geneSymbol: TMCC1
name: Transmembrane and coiled-coil domains protein 1
length: 653
go: ENSG00000172765;
snps: rs784689
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; rough endoplasmic reticulum [GO:0005791]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; endoplasmic reticulum organization [GO:0007029]; protein heterooligomerization [GO:0051291]; protein homooligomerization [GO:0051260]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O94876-1; Sequence=Displayed; Name=2; IsoId=O94876-2; Sequence=VSP_053924, VSP_053925; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24454821}; Multi-pass membrane protein {ECO:0000269|PubMed:24454821}.


uniprotID: Q9Y275
geneSymbol: TNFSF13B
reactome: R-HSA-5668541;R-HSA-5669034;R-HSA-5676594;
pdb: 1JH5;1KD7;1KXG;1OQD;1OQE;1OSG;3V56;4V46;4ZCH;5Y9J;6FXN;
length: 285
go: ENSG00000102524;
drug: DB08879;DB04272;
snps: rs201543678
name:
Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; B cell costimulation [GO:0031296]; B cell homeostasis [GO:0001782]; cell proliferation [GO:0008283]; immune response [GO:0006955]; immunoglobulin secretion [GO:0048305]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell proliferation [GO:0008284]; positive regulation of germinal center formation [GO:0002636]; positive regulation of T cell proliferation [GO:0042102]; signal transduction [GO:0007165]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y275-1; Sequence=Displayed; Name=2; Synonyms=DeltaBAFF; IsoId=Q9Y275-2; Sequence=VSP_041183; Name=3; Synonyms=Delta4BAFF; IsoId=Q9Y275-3; Sequence=VSP_047591, VSP_047592; 

location:
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 13b, soluble form: Secreted.


uniprotID: Q86YD3
geneSymbol: TMEM25
name: Transmembrane protein 25
length: 366
go: ENSG00000149582;
snps: rs35915434 rs12289253
sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q86YD3-1; Sequence=Displayed; Name=2; IsoId=Q86YD3-2; Sequence=VSP_012940; Name=3; IsoId=Q86YD3-3; Sequence=VSP_012939, VSP_012940; Name=4; IsoId=Q86YD3-4; Sequence=VSP_012941; Name=5; IsoId=Q86YD3-5; Sequence=VSP_012940, VSP_045635, VSP_012941; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Secreted {ECO:0000305}.


uniprotID: P62072
geneSymbol: TIMM10
reactome: R-HSA-1268020;
pdb: 2BSK;
name: Mitochondrial import inner membrane translocase subunit Tim10
sequence: MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELSKGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA
length: 90
go: ENSG00000134809;
opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; chaperone binding [GO:0051087]; protein homodimerization activity [GO:0042803]; protein transporter activity [GO:0008565]; transporter activity [GO:0005215]; zinc ion binding [GO:0008270]; chaperone-mediated protein transport [GO:0072321]; protein import into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.


uniprotID: Q9H0R3
geneSymbol: TMEM222
name: Transmembrane protein 222
length: 208
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H0R3-1; Sequence=Displayed; Name=2; IsoId=Q9H0R3-2; Sequence=VSP_020090; 


uniprotID: Q9BVC6
geneSymbol: TMEM109
name: Transmembrane protein 109 (Mitsugumin-23) (Mg23)
length: 243
go: ENSG00000110108;
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; nuclear outer membrane [GO:0005640]; sarcoplasmic reticulum membrane [GO:0033017]; voltage-gated ion channel activity [GO:0005244]; cellular response to gamma radiation [GO:0071480]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of cell death [GO:0060548]; regulation of ion transmembrane transport [GO:0034765]

location:
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}.


uniprotID: Q59H18
geneSymbol: TNNI3K
pdb: 4YFF;4YFI;6B5J;
length: 835
go: ENSG00000116783;ENSG00000259030;
snps: rs34874695 rs34521608 rs34335537 rs606231469 rs2274260 rs3737564 rs45578635 rs201613442 rs45614933
name:
Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein C-terminus binding [GO:0008022]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; troponin I binding [GO:0031013]; bundle of His cell to Purkinje myocyte communication [GO:0086069]; protein phosphorylation [GO:0006468]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart rate [GO:0002027]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=2 {ECO:0000269|PubMed:12721663}; IsoId=Q59H18-2; Sequence=Displayed; Name=1 {ECO:0000305}; IsoId=Q59H18-1; Sequence=VSP_039403; Note=Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.; Name=3 {ECO:0000305}; IsoId=Q59H18-3; Sequence=VSP_039403, VSP_051882, VSP_051883; Note=Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.; Name=4 {ECO:0000305}; IsoId=Q59H18-4; Sequence=VSP_039403, VSP_051884, VSP_051885; Note=Based on a naturally occurring readthrough transcript which produces a FPGT-TNNI3K fusion protein.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12721663}. Cytoplasm {ECO:0000269|PubMed:12721663}. Note=Expressed at lower levels in the cytoplasm.


uniprotID: Q9Y2Y6
geneSymbol: TMEM98
name: Transmembrane protein 98 (Protein TADA1)
length: 226
go: ENSG00000006042;
opentargets: endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]
snps: rs35124349 rs587777690
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8N816
geneSymbol: TMEM99
name: Transmembrane protein 99
length: 258
go: ENSG00000167920;
opentargets: integral component of membrane [GO:0016021]
snps: rs17474506 rs10558 rs1044806
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N816-1; Sequence=Displayed; Name=2; IsoId=Q8N816-2; Sequence=VSP_035635; 


uniprotID: Q9NYL9
geneSymbol: TMOD3
reactome: R-HSA-390522;
name: Tropomodulin-3 (Ubiquitous tropomodulin) (U-Tmod)
length: 352
go: ENSG00000138594;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
sequence:

opentargets:
cell-cell adherens junction [GO:0005913]; myofibril [GO:0030016]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; cadherin binding involved in cell-cell adhesion [GO:0098641]; tropomyosin binding [GO:0005523]; erythrocyte development [GO:0048821]; muscle contraction [GO:0006936]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]; positive regulation of mitotic cell cycle phase transition [GO:1901992]


uniprotID: Q08629
geneSymbol: SPOCK1
name: Testican-1 (Protein SPOCK)
length: 439
go: ENSG00000152377;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; neuromuscular junction [GO:0031594]; node of Ranvier [GO:0033268]; postsynaptic density [GO:0014069]; sarcoplasm [GO:0016528]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; extracellular matrix binding [GO:0050840]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]; cell adhesion [GO:0007155]; central nervous system neuron differentiation [GO:0021953]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of neuron projection development [GO:0010977]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; neuron migration [GO:0001764]; regulation of cell growth [GO:0001558]


uniprotID: Q6P9G4
geneSymbol: TMEM154
name: Transmembrane protein 154
length: 183
go: ENSG00000170006;
opentargets: integral component of membrane [GO:0016021]
snps: rs17855714
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MQAPRAALVFALVIALVPVGRGNYEELENSGDTTVESERPNKVTIPSTFAAVTIKETLNANINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYKRKRTKQEPSSQGSQSALQTYELGSENVKVPIFEEDTPSVMEIEMEELDKWMNSMNRNADFECLPTLKEEKESNHNPSDSES


uniprotID: A2RUT3
geneSymbol: TMEM89
name: Transmembrane protein 89
length: 159
opentargets: integral component of membrane [GO:0016021]; nucleus [GO:0005634]
snps: rs9834639
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MLHVLASLPLLLLLVTSASTHAWSRPLWYQVGLDLQPWGCQPKSVEGCRGGLSCPGYWLGPGASRIYPVAAVMITTTMLMICRKILQGRRRSQATKGEHPQVTTEPCGPWKRRAPISDHTLLRGVLHMLDALLVHIEGHLRHLATQRQIQIKGTSTQSG


uniprotID: Q92563
geneSymbol: SPOCK2
name: Testican-2 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2)
length: 424
go: ENSG00000107742;
snps: rs2306322
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191]; cellular response to leukemia inhibitory factor [GO:1990830]; extracellular matrix organization [GO:0030198]; negative regulation of endopeptidase activity [GO:0010951]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]; positive regulation of cell motility [GO:2000147]; positive regulation of cell-substrate adhesion [GO:0010811]; regulation of cell differentiation [GO:0045595]; synapse assembly [GO:0007416]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92563-1; Sequence=Displayed; Name=2; IsoId=Q92563-2; Sequence=VSP_045668, VSP_045669; Note=No experimental confirmation available.; 


uniprotID: P50591
geneSymbol: TNFSF10
reactome: R-HSA-140534;R-HSA-3371378;R-HSA-5213460;R-HSA-5218900;R-HSA-69416;R-HSA-75158;
pdb: 1D0G;1D2Q;1D4V;1DG6;1DU3;4N90;5CIR;
length: 281
go: ENSG00000121858;
snps: rs6763816 rs16845759
name:
Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)

sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; TRAIL binding [GO:0045569]; tumor necrosis factor receptor binding [GO:0005164]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; male gonad development [GO:0008584]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; response to insulin [GO:0032868]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P50591-1; Sequence=Displayed; Name=2; Synonyms=TRAIL-short, TRAIL-s; IsoId=P50591-2; Sequence=VSP_043507, VSP_043508; Note=Induced upon HIV infection, antagonizes signaling via TRAIL receptor R2 (TNFRSF10B).; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14609566}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:14609566}. Note=Exists both as membrane-bound and soluble form. {ECO:0000269|PubMed:14609566}.


uniprotID: Q9BV44
geneSymbol: THUMPD3
name: THUMP domain-containing protein 3
length: 507
go: ENSG00000134077;
snps: rs1129174
sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; tRNA (guanine) methyltransferase activity [GO:0016423]; tRNA methylation [GO:0030488]


uniprotID: Q96MV1
geneSymbol: TMEM56
name: Transmembrane protein 56
length: 263
go: ENSG00000152078;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9H1E5
geneSymbol: TMX4
name: Thioredoxin-related transmembrane protein 4 (Thioredoxin domain-containing protein 13)
length: 349
go: ENSG00000125827;
snps: rs1135711 rs2076015
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
cell [GO:0005623]; integral component of membrane [GO:0016021]; cell redox homeostasis [GO:0045454]; oxidation-reduction process [GO:0055114]


uniprotID: Q9HCN3
geneSymbol: TMEM8A
length: 771
go: ENSG00000129925;
snps: rs11248931 rs2071915 rs3743887
name:
Post-GPI attachment to proteins factor 6 (EC 3.1.1.4) (GPI processing phospholipase A2) (GPI-PLA2) (Protein M83) (Transmembrane protein 6) (Transmembrane protein 8) (Transmembrane protein 8A)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27881714}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:21752829}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: A0A087WTH1
geneSymbol: TMEM265
name: Transmembrane protein 265
length: 108
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:
MEDEEKAVEILGNTEAAHPPSPIRCCWLRLRCLAATSIICGCSCLGVMALVFAIKAEERHKAGRSEEAVRWGARARKLILASFAVWLAVLILGPLLLWLLSYAIAQAE


uniprotID: Q63HR2
geneSymbol: TNS2
pdb: 2DKQ;2KNO;2L6K;2LOZ;3HQC;
length: 1409
go: ENSG00000111077;
snps: rs11170389 rs11558984
name:
Tensin-2 (EC 3.1.3.-) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)

sequence:

opentargets:
focal adhesion [GO:0005925]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; phosphoprotein phosphatase activity [GO:0004721]; cellular homeostasis [GO:0019725]; collagen metabolic process [GO:0032963]; intracellular signal transduction [GO:0035556]; kidney development [GO:0001822]; multicellular organism growth [GO:0035264]; multicellular organismal homeostasis [GO:0048871]; negative regulation of cell proliferation [GO:0008285]; response to muscle activity [GO:0014850]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q63HR2-1; Sequence=Displayed; Name=2; IsoId=Q63HR2-2; Sequence=VSP_026460; Name=4; IsoId=Q63HR2-4; Sequence=VSP_026458; Name=5; IsoId=Q63HR2-5; Sequence=VSP_026457; Name=6; IsoId=Q63HR2-6; Sequence=VSP_026461; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11792844, ECO:0000269|PubMed:22019427}. Cell membrane {ECO:0000269|PubMed:11792844}; Peripheral membrane protein {ECO:0000269|PubMed:11792844}; Cytoplasmic side {ECO:0000269|PubMed:11792844}. Note=Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). {ECO:0000269|PubMed:22019427}.


uniprotID: B4DJY2
geneSymbol: TMEM233
length: 109
go: ENSG00000224982;
opentargets: integral component of membrane [GO:0016021]; membrane [GO:0016020]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Transmembrane protein 233 (Dispanin subfamily B member 2) (DSPB2) (Interferon-induced transmembrane domain-containing protein D2)

sequence:
MSQYAPSPDFKRALDSSPEANTEDDKTEEDVPMPKNYLWLTIVSCFCPAYPINIVALVFSIMSLNSYNDGDYEGARRLGRNAKWVAIASIIIGLLIIGISCAVHFTRNA


uniprotID: A6NGA9
geneSymbol: TMEM202
name: Transmembrane protein 202
length: 273
opentargets: integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
snps: rs16956904
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9H6X4
geneSymbol: TMEM134
name: Transmembrane protein 134
length: 195
go: ENSG00000172663;
opentargets: integral component of membrane [GO:0016021]; perinuclear region of cytoplasm [GO:0048471]
sequence:
MSAARPQFSIDDAFELSLEDGGPGPESSGVARFGPLHFERRARFEVADEDKQSRLRYQNLENDEDGAQASPEPDGGVGTRDSSRTSIRSSQWSFSTISSSTQRSYNTCCSWTQHPLIQKNRRVVLASFLLLLLGLVLILVGVGLEATPSPGVSSAIFFVPGFLLLVPGVYHVIFIYCAVKGHRGFQFFYLPYFEK

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H6X4-1; Sequence=Displayed; Name=2; IsoId=Q9H6X4-2; Sequence=VSP_023452; Name=3; IsoId=Q9H6X4-3; Sequence=VSP_023453, VSP_023454; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27899274}.


uniprotID: Q9HCN2
geneSymbol: TP53AIP1
reactome: R-HSA-6803204;
name: p53-regulated apoptosis-inducing protein 1 (p53AIP1)
length: 124
go: ENSG00000120471;
snps: rs35942033
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11030628}.
sequence:
MGSSSEASFRSAQASCSGARRQGLGRGDQNLSVMPPNGRAQTHTPGWVSDPLVLGAQVHGGCRGIEALSVSSGSWSSATVWILTGLGLGLSRPFLPGATVLRDRPLGSAFELSYDQKKAPLRLQ

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha; IsoId=Q9HCN2-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9HCN2-2; Sequence=VSP_027866, VSP_027867; Name=3; Synonyms=Gamma; IsoId=Q9HCN2-3; Sequence=VSP_027865; Note=Dubious isoform. Could be a cloning artifact.; Name=4; IsoId=Q9HCN2-4; Sequence=VSP_027868; 


uniprotID: P29144
geneSymbol: TPP2
reactome: R-HSA-983168;
length: 1249
go: ENSG00000134900;
name:
Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; aminopeptidase activity [GO:0004177]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; serine-type endopeptidase activity [GO:0004252]; tripeptidyl-peptidase activity [GO:0008240]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19747897}. Nucleus {ECO:0000269|PubMed:19747897}. Note=Translocates to the nucleus in responce to gamma-irradiation.


uniprotID: O14545
geneSymbol: TRAFD1
pdb: 2D9K;
name: TRAF-type zinc finger domain-containing protein 1 (Protein FLN29)
length: 582
go: ENSG00000135148;
opentargets: metal ion binding [GO:0046872]; negative regulation of innate immune response [GO:0045824]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14545-1; Sequence=Displayed; Name=2; IsoId=O14545-2; Sequence=VSP_056085, VSP_056086; Note=No experimental confirmation available.; 


uniprotID: O60296
geneSymbol: TRAK2
length: 914
go: ENSG00000115993;
snps: rs13022344 rs2244438 rs34594680
name:
Trafficking kinesin-binding protein 2 (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 3 protein)

sequence:

opentargets:
axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; GABA receptor binding [GO:0050811]; kinesin binding [GO:0019894]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; TPR domain binding [GO:0030911]; anterograde axonal transport [GO:0008089]; anterograde axonal transport of mitochondrion [GO:0098957]; anterograde dendritic transport of mitochondrion [GO:0098972]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; negative regulation of axonogenesis [GO:0050771]; neurogenesis [GO:0022008]; protein localization [GO:0008104]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60296-1; Sequence=Displayed; Name=2; IsoId=O60296-2; Sequence=VSP_053418, VSP_053419; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Colocalizes with MGARP at the mitochondria. Translocates from the cytoplasm to the mitochondria in a MGARP-dependent manner (By similarity). {ECO:0000250}.


uniprotID: Q96PN7
geneSymbol: TRERF1
length: 1200
go: ENSG00000124496;
snps: rs35162277 rs59159203 rs2295275 rs35978318 rs11751765
name:
Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132)

sequence:

opentargets:
cytosol [GO:0005829]; histone deacetylase complex [GO:0000118]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA binding, bending [GO:0008301]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nuclear receptor transcription coactivator activity [GO:0030374]; transcription coregulator activity [GO:0003712]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; cholesterol catabolic process [GO:0006707]; homeostatic process [GO:0042592]; multicellular organism development [GO:0007275]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of hormone biosynthetic process [GO:0046885]; steroid biosynthetic process [GO:0006694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96PN7-1; Sequence=Displayed; Name=2; Synonyms=Rapa-1; IsoId=Q96PN7-2; Sequence=VSP_015644, VSP_015645; Name=3; Synonyms=Rapa-2; IsoId=Q96PN7-3; Sequence=VSP_015644, VSP_015645, VSP_015646; Name=4; IsoId=Q96PN7-4; Sequence=VSP_015645; Note=Gene prediction based on EST data.; Name=5; IsoId=Q96PN7-5; Sequence=VSP_015645, VSP_015646; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.


uniprotID: Q9C026
geneSymbol: TRIM9
reactome: R-HSA-983168;
pdb: 2DB8;
length: 710
go: ENSG00000100505;
snps: rs2275462
name:
E3 ubiquitin-protein ligase TRIM9 (EC 2.3.2.27) (RING finger protein 91) (RING-type E3 ubiquitin transferase TRIM9) (Tripartite motif-containing protein 9)

sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; presynaptic cytosol [GO:0099523]; synaptic vesicle [GO:0008021]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; SNARE binding [GO:0000149]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of SNARE complex assembly [GO:0035544]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; synaptic vesicle exocytosis [GO:0016079]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Beta; IsoId=Q9C026-1; Sequence=Displayed; Name=4; IsoId=Q9C026-4; Sequence=VSP_007922, VSP_007923, VSP_007924; Note=May be due to a competing donor splice site, to exon inclusion and to intron retention.; Name=5; IsoId=Q9C026-5; Sequence=VSP_007925, VSP_007926; Note=May be due to intron retention.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20085810}. Cell projection, dendrite {ECO:0000269|PubMed:20085810}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q91ZY8}. Cell junction, synapse {ECO:0000250|UniProtKB:Q91ZY8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q91ZY8}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (Ref.7). {ECO:0000250|UniProtKB:Q91ZY8, ECO:0000269|PubMed:20085810}.


uniprotID: Q8N9V2
geneSymbol: TRIML1
length: 468
go: ENSG00000184108;
snps: rs13131525
name:
Probable E3 ubiquitin-protein ligase TRIML1 (EC 2.3.2.27) (RING finger protein 209) (RING-type E3 ubiquitin transferase TRIML1) (Tripartite motif family-like protein 1)

sequence:

opentargets:
metal ion binding [GO:0046872]; transferase activity [GO:0016740]; multicellular organism development [GO:0007275]; protein ubiquitination [GO:0016567]


uniprotID: Q9C037
geneSymbol: TRIM4
reactome: R-HSA-983168;
length: 500
go: ENSG00000146833;
snps: rs35432946 rs33998596
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811}.
name:
E3 ubiquitin-protein ligase TRIM4 (EC 2.3.2.27) (RING finger protein 87) (RING-type E3 ubiquitin transferase TRIM4) (Tripartite motif-containing protein 4)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; protein trimerization [GO:0070206]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Alpha; IsoId=Q9C037-1; Sequence=Displayed; Name=Beta; IsoId=Q9C037-2; Sequence=VSP_010197; Name=Gamma; IsoId=Q9C037-3; Sequence=VSP_010197, VSP_010198, VSP_010199; 


uniprotID: Q9BSJ1
geneSymbol: TRIM51
name: Tripartite motif-containing protein 51 (SPRY domain-containing protein 5)
length: 452
go: ENSG00000124900;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BSJ1-1; Sequence=Displayed; Name=2; IsoId=Q9BSJ1-2; Sequence=VSP_039765; 


uniprotID: A6NK02
geneSymbol: TRIM75P
name: Putative tripartite motif-containing protein 75 (Tripartite motif-containing protein 75 pseudogene)
length: 468
go: ENSG00000250374;
opentargets: extracellular space [GO:0005615]; intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: Q96RU8
geneSymbol: TRIB1
pdb: 5CEK;5CEM;5IGO;5IGQ;
name: Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1)
length: 372
go: ENSG00000173334;
snps: rs56285697 rs34349706 rs56056430 rs55953723 rs35454769 rs16900603
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; mitogen-activated protein kinase kinase binding [GO:0031434]; protein kinase inhibitor activity [GO:0004860]; transcription factor binding [GO:0008134]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase regulator activity [GO:0055106]; JNK cascade [GO:0007254]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of lipopolysaccharide-mediated signaling pathway [GO:0031665]; negative regulation of neutrophil differentiation [GO:0045659]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of eosinophil differentiation [GO:0045645]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; regulation of MAP kinase activity [GO:0043405]; response to lipopolysaccharide [GO:0032496]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96RU8-1; Sequence=Displayed; Name=2; IsoId=Q96RU8-2; Sequence=VSP_054894; Note=No experimental confirmation available.; 


uniprotID: O94972
geneSymbol: TRIM37
reactome: R-HSA-983168;
pdb: 3LRQ;
length: 964
go: ENSG00000108395;
snps: rs386834004 rs17853504 rs121908391 rs386834009 rs7222388
name:
E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)

sequence:

opentargets:
aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; peroxisome [GO:0005777]; chromatin binding [GO:0003682]; protein homodimerization activity [GO:0042803]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; aggresome assembly [GO:0070842]; histone H2A monoubiquitination [GO:0035518]; histone H2A-K119 monoubiquitination [GO:0036353]; negative regulation of centriole replication [GO:0046600]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein autoubiquitination [GO:0051865]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TRIM37a {ECO:0000303|PubMed:16310976}, TRIM37b {ECO:0000303|PubMed:16310976}; IsoId=O94972-1; Sequence=Displayed; Name=2; IsoId=O94972-2; Sequence=VSP_011919, VSP_011920; Note=No experimental confirmation available.; Name=3; IsoId=O94972-3; Sequence=VSP_057468; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15885686}. Peroxisome {ECO:0000269|PubMed:11938494}. Note=Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation. {ECO:0000269|PubMed:15885686}.


uniprotID: Q9HCM9
geneSymbol: TRIM39
reactome: R-HSA-983168;
pdb: 2DID;2DIF;2ECJ;
length: 518
go: ENSG00000204599;
name:
E3 ubiquitin-protein ligase TRIM39 (EC 2.3.2.27) (RING finger protein 23) (RING-type E3 ubiquitin transferase TRIM39) (Testis-abundant finger protein) (Tripartite motif-containing protein 39)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; identical protein binding [GO:0042802]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; positive regulation of apoptotic signaling pathway [GO:2001235]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HCM9-1; Sequence=Displayed; Name=2; IsoId=Q9HCM9-2; Sequence=VSP_005755; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19100260}. Mitochondrion {ECO:0000269|PubMed:19100260}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1.


uniprotID: Q9UNG2
geneSymbol: TNFSF18
reactome: R-HSA-5669034;
pdb: 2Q1M;2R30;2R32;3B93;3B94;
length: 199
go: ENSG00000120337;
name:
Tumor necrosis factor ligand superfamily member 18 (Activation-inducible TNF-related ligand) (AITRL) (Glucocorticoid-induced TNF-related ligand) (hGITRL)

sequence:
MTLHPSPITCEFLFSTALISPKMCLSHLENMPLSHSRTQGAQRSSWKLWLFCSIVMLLFLCSFSWLIFIFLQLETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS

opentargets:
cell surface [GO:0009986]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor superfamily binding [GO:0032813]; adaptive immune response [GO:0002250]; cell-cell signaling [GO:0007267]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell adhesion [GO:0045785]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of T cell proliferation [GO:0042129]; signal transduction [GO:0007165]; T cell proliferation involved in immune response [GO:0002309]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17449724}; Single-pass type II membrane protein {ECO:0000269|PubMed:17449724}.


