# annotation

uniprotID: Q3MIT2
geneSymbol: PUS10
pdb: 2V9K;
length: 529
go: ENSG00000162927;
name:
Putative tRNA pseudouridine synthase Pus10 (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase)

sequence:

opentargets:
pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; tRNA pseudouridine synthesis [GO:0031119]


uniprotID: P25786
geneSymbol: PSMA1
length: 263
go: ENSG00000129084;
snps: rs17850016
name:
Proteasome subunit alpha type-1 (EC 3.4.25.1) (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)

sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; polysome [GO:0005844]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; RNA binding [GO:0003723]; threonine-type endopeptidase activity [GO:0004298]; immune system process [GO:0002376]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Short; IsoId=P25786-1; Sequence=Displayed; Name=Long; IsoId=P25786-2; Sequence=VSP_005279; 


uniprotID: Q02127
geneSymbol: DHODH
reactome: R-HSA-500753;
length: 395
go: ENSG00000102967;
pdb:
1D3G;1D3H;2B0M;2BXV;2FPT;2FPV;2FPY;2FQI;2PRH;2PRL;2PRM;2WV8;3F1Q;3FJ6;3FJL;3G0U;3G0X;3KVJ;3KVK;3KVL;3KVM;3U2O;3W7R;3ZWS;3ZWT;4IGH;4JGD;4JS3;4JTS;4JTT;4JTU;4LS0;4LS1;4LS2;4OQV;4RK8;4RKA;4RLI;4RR4;4YLW;4ZL1;4ZMG;5H2Z;5H73;5HIN;5HQE;5K9C;5K9D;5MUT;5MVC;5MVD;5TCE;5ZF4;5ZF7;5ZF8;5ZF9;5ZFA;5ZFB;6CJF;6CJG;6ET4;6FMD;

name:
Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)

sequence:

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; dihydroorotate dehydrogenase activity [GO:0004152]; drug binding [GO:0008144]; FMN binding [GO:0010181]; ubiquinone binding [GO:0048039]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; female pregnancy [GO:0007565]; lactation [GO:0007595]; positive regulation of apoptotic process [GO:0043065]; pyrimidine nucleoside biosynthetic process [GO:0046134]; pyrimidine ribonucleotide biosynthetic process [GO:0009220]; regulation of mitochondrial fission [GO:0090140]; response to caffeine [GO:0031000]; response to L-arginine [GO:1903576]; response to starvation [GO:0042594]

drug:
DB07561;DB08172;DB08169;DB07443;DB07976;DB03805;DB01117;DB03480;DB04147;DB01097;DB02262;DB03247;DB05125;DB08880;

snps:
rs3213422 rs267606765 rs201230446 rs267606766 rs267606769 rs267606767 rs267606767 rs267606768 rs201947120 rs779076692 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10727948}; Single-pass membrane protein {ECO:0000269|PubMed:10727948}.


uniprotID: P30566
geneSymbol: ADSL
reactome: R-HSA-73817;
pdb: 2J91;2VD6;4FFX;4FLC;
name: Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)
length: 484
go: ENSG00000239900;
sequence:

opentargets:
cytosol [GO:0005829]; (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity [GO:0070626]; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [GO:0004018]; 'de novo' AMP biosynthetic process [GO:0044208]; 'de novo' IMP biosynthetic process [GO:0006189]; aerobic respiration [GO:0009060]; AMP biosynthetic process [GO:0006167]; protein tetramerization [GO:0051262]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to hypoxia [GO:0001666]; response to muscle activity [GO:0014850]; response to nutrient [GO:0007584]; response to starvation [GO:0042594]

snps:
rs143083947 rs5757921 rs119450942 rs374259530 rs756210458 rs11089991 rs28941471 rs119450944 rs746501563 rs373458753 rs202064195 rs370851726 rs376533026 rs755492501 rs763542069 rs119450943 rs119450941 rs554254383 rs119450940 rs777821034 rs372895468 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P30566-1; Sequence=Displayed; Name=2; Synonyms=Delta-ADSL; IsoId=P30566-2; Sequence=VSP_000318; Note=Lacks enzymatic activity.; 


uniprotID: A1KZ92
geneSymbol: PXDNL
length: 1463
go: ENSG00000147485;
snps: rs7833909 rs16916235 rs16916207 rs2977020 rs11774588 rs7827446 rs1052704
name:
Peroxidasin-like protein (EC 1.11.1.7) (Cardiac peroxidase) (Vascular peroxidase 2) (polysomal ribonuclease 1) (PRM1)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; endonuclease activity [GO:0004519]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; hydrogen peroxide catabolic process [GO:0042744]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A1KZ92-1; Sequence=Displayed; Name=2; IsoId=A1KZ92-2; Sequence=VSP_033070, VSP_033071; Note=No experimental confirmation available.; Name=PMR1; IsoId=A1KZ92-3; Sequence=VSP_044240, VSP_044241; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform PMR1: Cytoplasm. Note=Associates with polysomes.


uniprotID: O15067
geneSymbol: PFAS
reactome: R-HSA-73817;
length: 1338
go: ENSG00000178921;
drug: DB00142;DB00130;
snps: rs9891699 rs4791641 rs35217368 rs11078738
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase) (FGAR amidotransferase) (FGAR-AT) (Formylglycinamide ribotide amidotransferase)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylformylglycinamidine synthase activity [GO:0004642]; 'de novo' IMP biosynthetic process [GO:0006189]; anterior head development [GO:0097065]; glutamine metabolic process [GO:0006541]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to drug [GO:0042493]


uniprotID: B1ATL7
geneSymbol: PRR32
name: Proline-rich protein 32
length: 298
go: ENSG00000183631;
snps: rs12835991 rs4289953
sequence:


uniprotID: A8MZF0
geneSymbol: PRR33
name: Proline-rich protein 33
length: 331
sequence:


uniprotID: P24158
geneSymbol: PRTN3
reactome: R-HSA-140875;R-HSA-449836;R-HSA-6798695;R-HSA-6803157;
pdb: 1FUJ;
length: 256
go: ENSG00000196415;
drug: DB05161;
snps: rs351111 rs1042281 rs1042282
name:
Myeloblastin (EC 3.4.21.76) (AGP7) (C-ANCA antigen) (Leukocyte proteinase 3) (PR-3) (PR3) (Neutrophil proteinase 4) (NP-4) (P29) (Wegener autoantigen)

sequence:

opentargets:
azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; plasma membrane raft [GO:0044853]; enzyme binding [GO:0019899]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; signaling receptor binding [GO:0005102]; antimicrobial humoral response [GO:0019730]; blood coagulation [GO:0007596]; cell-cell junction maintenance [GO:0045217]; collagen catabolic process [GO:0030574]; cytokine-mediated signaling pathway [GO:0019221]; mature conventional dendritic cell differentiation [GO:0097029]; membrane protein ectodomain proteolysis [GO:0006509]; negative regulation of phagocytosis [GO:0050765]; neutrophil degranulation [GO:0043312]; neutrophil extravasation [GO:0072672]; phagocytosis [GO:0006909]; positive regulation of cell proliferation [GO:0008284]; positive regulation of GTPase activity [GO:0043547]; proteolysis [GO:0006508]

location:
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245, ECO:0000305|PubMed:17244676}. Secreted {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:28240246}. Cell membrane {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}; Peripheral membrane protein {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}; Extracellular side {ECO:0000269|PubMed:17244676, ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246}. Membrane raft {ECO:0000269|PubMed:21193407}; Peripheral membrane protein {ECO:0000269|PubMed:21193407}; Extracellular side {ECO:0000269|PubMed:21193407}. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils (PubMed:2033050, PubMed:3198760, PubMed:7897245, PubMed:18462208). Secreted upon neutrophil stimulation by TNF-alpha, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration (PubMed:22266279, PubMed:28240246). Following secretion tethered to the cell membrane by CD177 (PubMed:18462208, PubMed:22266279). {ECO:0000269|PubMed:18462208, ECO:0000269|PubMed:2033050, ECO:0000269|PubMed:22266279, ECO:0000269|PubMed:28240246, ECO:0000269|PubMed:3198760, ECO:0000269|PubMed:7897245}.


uniprotID: O14603
geneSymbol: PRY; PRY2; PRYP3; PRYP4
name: PTPN13-like protein, Y-linked (Testis-specific PTP-BL-related Y protein)
length: 147
sequence:
MGATGLGFLLSWRQDNLNGTDCQGCNILYFSETTGSMCSELSLNRGLEARRKKDLKDSFLWRYGKVGCISLPLREMTAWINPPQISEIFQGYHQRVHGADALSLQTNSLRSRLSSQCLGQSFLLRTLERGRGFRALGDICGHVHEED

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14603-1; Sequence=Displayed; Name=2; IsoId=O14603-2; Sequence=VSP_004068, VSP_004069; Note=No experimental confirmation available.; 


uniprotID: P21108
geneSymbol: PRPS1L1
reactome: R-HSA-73843;
length: 318
go: ENSG00000229937;
snps: rs3800962
name:
Ribose-phosphate pyrophosphokinase 3 (EC 2.7.6.1) (Phosphoribosyl pyrophosphate synthase 1-like 1) (PRPS1-like 1) (Phosphoribosyl pyrophosphate synthase III) (PRS-III)

sequence:

opentargets:
cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; nucleoside metabolic process [GO:0009116]; nucleotide biosynthetic process [GO:0009165]; purine nucleotide biosynthetic process [GO:0006164]; ribonucleoside monophosphate biosynthetic process [GO:0009156]


uniprotID: P43686
geneSymbol: PSMC4
length: 418
go: ENSG00000013275;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
pdb:
2DVW;5GJQ;5GJR;5L4G;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHJ;5VHM;5VHN;5VHO;5VHP;5VHQ;5VHR;5VHS;

name:
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; inclusion body [GO:0016234]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; synapse [GO:0045202]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; blastocyst development [GO:0001824]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P43686-1; Sequence=Displayed; Name=2; IsoId=P43686-2; Sequence=VSP_000022; Note=No experimental confirmation available.; 


uniprotID: P62333
geneSymbol: PSMC6
length: 389
go: ENSG00000100519;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
pdb:
5GJQ;5GJR;5L4G;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHJ;5VHM;5VHN;5VHO;5VHP;5VHQ;5VHR;5VHS;

name:
26S proteasome regulatory subunit 10B (26S proteasome AAA-ATPase subunit RPT4) (Proteasome 26S subunit ATPase 6) (Proteasome subunit p42)

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating ATPase activity [GO:0036402]; protein binding, bridging [GO:0030674]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; post-translational protein modification [GO:0043687]; protein deubiquitination [GO:0016579]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: O14818
geneSymbol: PSMA7
name: Proteasome subunit alpha type-7 (EC 3.4.25.1) (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)
length: 248
go: ENSG00000101182;
drug: DB07558;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; identical protein binding [GO:0042802]; threonine-type endopeptidase activity [GO:0004298]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=O14818-1; Sequence=Displayed; Name=2; IsoId=O14818-2; Sequence=VSP_005281; Name=3; IsoId=O14818-4; Sequence=VSP_046556, VSP_046557; 


uniprotID: Q9BQR3
geneSymbol: PRSS27
name: Serine protease 27 (EC 3.4.21.-) (Marapsin) (Pancreasin)
length: 290
go: ENSG00000172382;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
anchored component of plasma membrane [GO:0046658]; extracellular region [GO:0005576]; extrinsic component of plasma membrane [GO:0019897]; serine-type endopeptidase activity [GO:0004252]


uniprotID: P25789
geneSymbol: PSMA4
length: 261
go: ENSG00000041357;
name:
Proteasome subunit alpha type-4 (EC 3.4.25.1) (Macropain subunit C9) (Multicatalytic endopeptidase complex subunit C9) (Proteasome component C9) (Proteasome subunit L)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P25789-1; Sequence=Displayed; Name=2; IsoId=P25789-2; Sequence=VSP_043102; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345}. Nucleus {ECO:0000269|PubMed:12181345}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250|UniProtKB:Q9R1P0}.


uniprotID: P22102
geneSymbol: GART
reactome: R-HSA-73817;
length: 1010
go: ENSG00000159131;
drug: DB03546;DB02236;DB00642;
snps: rs1804387 rs8788 rs35927582 rs34588874 rs8971
pdb:
1MEJ;1MEN;1MEO;1NJS;1RBM;1RBQ;1RBY;1RBZ;1RC0;1RC1;1ZLX;1ZLY;2QK4;2V9Y;4EW1;4EW2;4EW3;4ZYT;4ZYU;4ZYV;4ZYW;4ZYX;4ZYY;4ZYZ;4ZZ0;4ZZ1;4ZZ2;4ZZ3;5J9F;

name:
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; phosphoribosylamine-glycine ligase activity [GO:0004637]; phosphoribosylformylglycinamidine cyclo-ligase activity [GO:0004641]; phosphoribosylglycinamide formyltransferase activity [GO:0004644]; 'de novo' IMP biosynthetic process [GO:0006189]; adenine biosynthetic process [GO:0046084]; brainstem development [GO:0003360]; cerebellum development [GO:0021549]; cerebral cortex development [GO:0021987]; glycine metabolic process [GO:0006544]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]; response to inorganic substance [GO:0010035]; response to organic substance [GO:0010033]; tetrahydrofolate biosynthetic process [GO:0046654]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=P22102-1; Sequence=Displayed; Name=Short; IsoId=P22102-2; Sequence=VSP_005517; 


uniprotID: Q9H606
geneSymbol: PRORY
name: Proline-rich protein, Y-linked
length: 182
sequence:
MMRRSPSGLKSPRVSQGRKPRDPESLLFLRCCLGSEPHNLSSLLSPEAGQEPLPKLLPQPLAGHAAWGIHGVPTSLLLAGECWGQGMAVPADPPPASPYRTSPRPPPGPLPRYRPQQHLLLPLGRLHALCPGCPLQQSLQFERGTLSAPRLWSWMKLETIILSKLSQGQKTKHRMFSLISES


uniprotID: Q86WR7
geneSymbol: PROSER2
name: Proline and serine-rich protein 2
length: 435
go: ENSG00000148426;
snps: rs12253554
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86WR7-1; Sequence=Displayed; Name=2; IsoId=Q86WR7-2; Sequence=VSP_014955; Note=No experimental confirmation available.; 


uniprotID: Q8IYP2
geneSymbol: PRSS58
name: Serine protease 58 (EC 3.4.21.4) (Trypsin-X3)
length: 241
go: ENSG00000258223;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]


uniprotID: Q2VWP7
geneSymbol: PRTG
name: Protogenin (Protein Shen-Dan)
length: 1150
go: ENSG00000166450;
snps: rs16976466 rs10518816 rs1438914
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
sequence:

opentargets:
extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; negative regulation of neurogenesis [GO:0050768]; protein homooligomerization [GO:0051260]


uniprotID: Q5FWE3
geneSymbol: PRRT3
name: Proline-rich transmembrane protein 3
length: 981
go: ENSG00000163704;
opentargets: integral component of membrane [GO:0016021]
snps: rs279601 rs55847610 rs55847233 rs59465469 rs2279794
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5FWE3-1; Sequence=Displayed; Name=2; IsoId=Q5FWE3-2; Sequence=VSP_020845; Note=No experimental confirmation available.; Name=3; IsoId=Q5FWE3-3; Sequence=VSP_020846, VSP_020847; 


uniprotID: E5RG02
geneSymbol: PRSS46P
name: Putative serine protease 46 (EC 3.4.21.-) (Serine protease 46 pseudogene)
length: 174
opentargets: serine-type endopeptidase activity [GO:0004252]
sequence:
MACGPGDLQSLTSPLSSARLDYQPSIEGPWLRACGQTNVSCRVVKGKLVEVGKWPWQVSILFLGTYICSGSLIHHQWVLTAAHCLQRFKDLSLYSVMVGVHQRPENSTQLPLTRMVIHKDFSNLMSQDIALLKLRDSISWSPFVQPVCLPNIKFKPSIGSMCWVIGWGTTGKKG


uniprotID: O95084
geneSymbol: PRSS23
reactome: R-HSA-381426;R-HSA-8957275;
name: Serine protease 23 (EC 3.4.21.-) (Putative secreted protein Zsig13)
length: 383
go: ENSG00000150687;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; serine-type endopeptidase activity [GO:0004252]; cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95084-1; Sequence=Displayed; Name=2; IsoId=O95084-2; Sequence=VSP_056628; Note=No experimental confirmation available.; 


uniprotID: P04070
geneSymbol: PROC
pdb: 1AUT;1LQV;1PCU;2PCT;3F6U;3JTC;4DT7;
length: 461
go: ENSG00000115718;
drug: DB00025;DB00170;DB00464;
reactome:
R-HSA-140837;R-HSA-140875;R-HSA-159740;R-HSA-159763;R-HSA-159782;R-HSA-202733;R-HSA-381426;R-HSA-8957275;

name:
Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; cellular protein metabolic process [GO:0044267]; ER to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of apoptotic process [GO:0043066]; negative regulation of blood coagulation [GO:0030195]; negative regulation of coagulation [GO:0050819]; negative regulation of inflammatory response [GO:0050728]; positive regulation of establishment of endothelial barrier [GO:1903142]; post-translational protein modification [GO:0043687]; proteolysis [GO:0006508]

snps:
rs769900251 rs774572099 rs369504169 rs767626189 rs764546127 rs574949343 rs757583846 rs121918148 rs199469481 rs121918149 rs199469479 rs200234655 rs374476971 rs121918159 rs199469474 rs199469470 rs748920874 rs146922325 rs371071104 rs121918145 rs199469476 rs121918143 rs121918153 rs121918152 rs199469483 rs121918155 rs774584131 rs759557871 rs121918156 rs767112991 rs121918154 rs121918151 rs200721675 rs199469471 rs121918144 rs121918146 rs121918160 rs199469480 rs201907715 rs121918150 rs766261022 rs767730328 rs769277939 rs756467027 rs759316085 rs142742242 rs199469472 rs753436021 rs121918142 rs121918157 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P04070-1; Sequence=Displayed; Name=2; IsoId=P04070-2; Sequence=VSP_054393, VSP_054394; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25618265}. Golgi apparatus {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}. Endoplasmic reticulum {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}.


uniprotID: A6NIE9
geneSymbol: PRSS29P
length: 313
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
name:
Putative serine protease 29 (EC 3.4.21.-) (Implantation serine proteinase 2-like protein) (ISP2-like protein)

sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]


uniprotID: Q9UMS4
geneSymbol: PRPF19
reactome: R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-72163;
pdb: 4LG8;5MQF;5XJC;5YZG;5Z56;5Z57;
length: 504
go: ENSG00000110107;
name:
Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; lipid droplet [GO:0005811]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; site of double-strand break [GO:0035861]; spindle [GO:0005819]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; identical protein binding [GO:0042802]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; ubiquitin-ubiquitin ligase activity [GO:0034450]; cellular protein localization [GO:0034613]; double-strand break repair via nonhomologous end joining [GO:0006303]; generation of catalytic spliceosome for first transesterification step [GO:0000349]; inner cell mass cell proliferation [GO:0001833]; lipid biosynthetic process [GO:0008610]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of neuron differentiation [GO:0045666]; proteasomal protein catabolic process [GO:0010498]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; signal transduction involved in DNA damage checkpoint [GO:0072422]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]; transcription-coupled nucleotide-excision repair [GO:0006283]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20176811}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11082287}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11082287}. Cytoplasm {ECO:0000269|PubMed:11435423}. Lipid droplet {ECO:0000250|UniProtKB:Q99KP6}. Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing chromatin. Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:18263876}.


uniprotID: P04280
geneSymbol: PRB1
length: 392
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3521730}.
name:
Basic salivary proline-rich protein 1 (Salivary proline-rich protein) [Cleaved into: Proline-rich peptide II-2; Basic peptide IB-6; Peptide P-H]

sequence:


uniprotID: O43172
geneSymbol: PRPF4
reactome: R-HSA-72163;
pdb: 1MZW;3JCR;5O9Z;
length: 522
go: ENSG00000136875;
snps: rs41296057 rs587777599
name:
U4/U6 small nuclear ribonucleoprotein Prp4 (PRP4 homolog) (hPrp4) (U4/U6 snRNP 60 kDa protein) (WD splicing factor Prp4)

sequence:

opentargets:
Cajal body [GO:0015030]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; spliceosomal snRNP complex [GO:0097525]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 snRNP [GO:0071001]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U4 snRNA binding [GO:0030621]; U6 snRNA binding [GO:0017070]; mRNA splicing, via spliceosome [GO:0000398]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43172-1; Sequence=Displayed; Name=2; IsoId=O43172-2; Sequence=VSP_006785; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25383878, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:9257651, ECO:0000269|PubMed:9328476, ECO:0000269|PubMed:9404889}. Nucleus speckle {ECO:0000305}.


uniprotID: Q9BWN1
geneSymbol: PRR14
name: Proline-rich protein 14
length: 585
go: ENSG00000156858;
snps: rs3747481
sequence:

opentargets:
chromosome [GO:0005694]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654]; muscle organ development [GO:0007517]

location:
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24209742}. Nucleus {ECO:0000269|PubMed:25906157}. Nucleus lamina {ECO:0000269|PubMed:24209742}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24209742}. Note=During interphase, associated with peripheral heterochromatin at the nuclear lamina. Released from the nuclear lamina in mitotic prophase and remains highly dispersed in metaphase. Associates with chromatin at the onset of anaphase and relocalizes to the nuclear lamina in telophase. {ECO:0000269|PubMed:24209742}.


uniprotID: P25787
geneSymbol: PSMA2
length: 234
go: ENSG00000106588;ENSG00000256646;
name:
Proteasome subunit alpha type-2 (EC 3.4.25.1) (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; neutrophil degranulation [GO:0043312]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; response to virus [GO:0009615]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345}. Nucleus {ECO:0000269|PubMed:12181345}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:P49722}.


uniprotID: I3L0S3
geneSymbol: PYCARD-AS1
length: 204
name:
Putative uncharacterized protein PYCARD-AS1 (PYCARD antisense RNA 1) (PYCARD antisense gene protein 1) (PYCARD opposite strand protein)

sequence:


uniprotID: P07737
geneSymbol: PFN1
reactome: R-HSA-114608;R-HSA-376176;R-HSA-4086400;R-HSA-5663220;
pdb: 1AWI;1CF0;1CJF;1FIK;1FIL;1PFL;2PAV;2PBD;3CHW;4X1L;4X1M;4X25;
name: Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
length: 140
go: ENSG00000108518;
drug: DB07908;
snps: rs387907264 rs387907265 rs140547520 rs387907266
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
sequence:
MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFYVNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY

opentargets:
blood microparticle [GO:0072562]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; nucleus [GO:0005634]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; adenyl-nucleotide exchange factor activity [GO:0000774]; cadherin binding [GO:0045296]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; proline-rich region binding [GO:0070064]; Rho GTPase binding [GO:0017048]; RNA binding [GO:0003723]; actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of actin filament bundle assembly [GO:0032232]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATPase activity [GO:0032781]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ruffle assembly [GO:1900029]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of transcription by RNA polymerase II [GO:0006357]; synapse maturation [GO:0060074]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]


uniprotID: O94906
geneSymbol: PRPF6
reactome: R-HSA-72163;R-HSA-72165;
pdb: 3JCR;5O9Z;
length: 941
go: ENSG00000101161;
snps: rs387907100
name:
Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; androgen receptor binding [GO:0050681]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA localization [GO:0006403]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal complex assembly [GO:0000245]; spliceosomal tri-snRNP complex assembly [GO:0000244]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O94906-1; Sequence=Displayed; Name=2; IsoId=O94906-2; Sequence=VSP_041857; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:10561546, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}. Nucleus speckle {ECO:0000269|PubMed:21549338}. Note=Localized in splicing speckles. {ECO:0000269|PubMed:21549338}.


uniprotID: Q6P2Q9
geneSymbol: PRPF8
reactome: R-HSA-72163;R-HSA-72165;
length: 2335
go: ENSG00000174231;
location: SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.
pdb:
3E9L;3ENB;3JCR;3LRU;4JK7;4JK8;4JK9;4JKA;4JKB;4JKC;4JKD;4JKE;4JKF;4JKG;4JKH;4KIT;5MQF;5O9Z;5XJC;5YZG;5Z56;5Z57;5Z58;6FF4;

name:
Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; U5 snRNP [GO:0005682]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; second spliceosomal transesterification activity [GO:0000386]; U1 snRNA binding [GO:0030619]; U2 snRNA binding [GO:0030620]; U5 snRNA binding [GO:0030623]; U6 snRNA binding [GO:0017070]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]

snps:
rs1043391 rs11559304 rs1043396 rs1043399 rs121434239 rs121434240 rs121434236 rs121434236 rs121434238 


uniprotID: A8MTI9
geneSymbol: PRSS47
name: Putative serine protease 47 (EC 3.4.21.-)
length: 375
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; proteolysis [GO:0006508]


uniprotID: Q7RTY5
geneSymbol: PRSS48
name: Serine protease 48 (EC 3.4.21.-) (Epidermis-specific serine protease-like protein)
length: 328
go: ENSG00000189099;
snps: rs36097019 rs17027505 rs13126069
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7RTY5-2; Sequence=Displayed; Name=2; IsoId=Q7RTY5-3; Sequence=VSP_033287; 


uniprotID: P28066
geneSymbol: PSMA5
length: 241
go: ENSG00000143106;
name:
Proteasome subunit alpha type-5 (EC 3.4.25.1) (Macropain zeta chain) (Multicatalytic endopeptidase complex zeta chain) (Proteasome zeta chain)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; secretory granule lumen [GO:0034774]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; neutrophil degranulation [GO:0043312]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P28066-1; Sequence=Displayed; Name=2; IsoId=P28066-2; Sequence=VSP_046241; Note=No experimental confirmation available.; 


uniprotID: Q9P215
geneSymbol: POGK
name: Pogo transposable element with KRAB domain
length: 609
go: ENSG00000143157;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; multicellular organism development [GO:0007275]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: Q9UNA4
geneSymbol: POLI
reactome: R-HSA-5656121;R-HSA-5656169;
name: DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)
length: 740
go: ENSG00000101751;
snps: rs3218778 rs3218784 rs3218783 rs3730823 rs3218786 rs3218787 rs8305
pdb:
1T3N;1ZET;2ALZ;2DPI;2DPJ;2FLL;2FLN;2FLP;2KHU;2KHW;2KTF;2L0F;2L0G;2MBB;3EPG;3EPI;3G6V;3G6X;3G6Y;3GV5;3GV7;3GV8;3H40;3H4B;3H4D;3NGD;3OSN;3Q8P;3Q8Q;3Q8R;3Q8S;4EBC;4EBD;4EBE;4EYH;4EYI;4FS1;4FS2;5KT2;5KT3;5KT4;5KT5;5KT6;5KT7;5ULW;5ULX;

sequence:

opentargets:
cytoplasmic ribonucleoprotein granule [GO:0036464]; intracellular [GO:0005622]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; damaged DNA binding [GO:0003684]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; error-prone translesion synthesis [GO:0042276]; translesion synthesis [GO:0019985]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12606586}. Note=Accumulates at replication forks after DNA damage.


uniprotID: Q9NPJ4
geneSymbol: PNRC2
reactome: R-HSA-975957;
pdb: 4B6H;5KQ1;5KQ4;
name: Proline-rich nuclear receptor coactivator 2
length: 139
go: ENSG00000189266;
sequence:
MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; deadenylation-independent decapping of nuclear-transcribed mRNA [GO:0031087]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NPJ4-1; Sequence=Displayed; Name=2; IsoId=Q9NPJ4-2; Sequence=VSP_037463; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19150429}. Cytoplasm, P-body {ECO:0000269|PubMed:19150429}.


uniprotID: Q86V59
geneSymbol: PNMA8A
name: Paraneoplastic antigen-like protein 8A (PNMA-like protein 1)
length: 439
go: ENSG00000182013;
snps: rs12610254 rs7248888
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86V59-1; Sequence=Displayed; Name=2; IsoId=Q86V59-2; Sequence=VSP_032441, VSP_032442; 


uniprotID: Q8NA72
geneSymbol: POC5
name: Centrosomal protein POC5 (Protein of centriole 5) (hPOC5)
length: 575
go: ENSG00000152359;
snps: rs2307111 rs17672542 rs34678567
sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NA72-1; Sequence=Displayed; Name=2; IsoId=Q8NA72-2; Sequence=VSP_024098, VSP_024100; Note=No experimental confirmation available.; Name=3; IsoId=Q8NA72-3; Sequence=VSP_024099; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19349582}. Note=Localized to the distal portion of centrioles.


uniprotID: Q03052
geneSymbol: POU3F1
length: 451
go: ENSG00000185668;
location: SUBCELLULAR LOCATION: Nucleus.
name:
POU domain, class 3, transcription factor 1 (Octamer-binding protein 6) (Oct-6) (Octamer-binding transcription factor 6) (OTF-6) (POU domain transcription factor SCIP)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; axon ensheathment [GO:0008366]; forebrain development [GO:0030900]; keratinocyte differentiation [GO:0030216]; myelination in peripheral nervous system [GO:0022011]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]


uniprotID: Q86YR6
geneSymbol: POTED
length: 584
go: ENSG00000166351;
opentargets: plasma membrane [GO:0005886]
snps: rs6517869 rs6517870
name:
POTE ankyrin domain family member D (ANKRD26-like family B member 3) (Ankyrin repeat domain-containing protein 21) (Prostate, ovary, testis-expressed protein) (Protein POTE)

sequence:

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12475935, ECO:0000269|PubMed:15276201}; Peripheral membrane protein {ECO:0000269|PubMed:12475935, ECO:0000269|PubMed:15276201}.


uniprotID: Q13522
geneSymbol: PPP1R1A
name: Protein phosphatase 1 regulatory subunit 1A (Protein phosphatase inhibitor 1) (I-1) (IPP-1)
length: 171
snps: rs1249958 rs34376731
sequence:
MEQDNSPRKIQFTVPLLEPHLDPEAAEQIRRRRPTPATLVLTSDQSSPEIDEDRIPNPHLKSTLAMSPRQRKKMTRITPTMKELQMMVEHHLGQQQQGEEPEGAAESTETQESRPPGIPDTEVESRLGTSGTAKKTAECIPKTHERGSKEPSTKEPSTHIPPLDSKGANSV

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; protein serine/threonine phosphatase inhibitor activity [GO:0004865]; glycogen metabolic process [GO:0005977]; intracellular signal transduction [GO:0035556]


uniprotID: Q8N3Z0
geneSymbol: PRSS35
name: Inactive serine protease 35
length: 413
go: ENSG00000146250;
opentargets: extracellular region [GO:0005576]
snps: rs504593
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:


uniprotID: Q7RTY9
geneSymbol: PRSS41
reactome: R-HSA-163125;
name: Serine protease 41 (EC 3.4.21.-) (Testis serine protease 1) (TESSP-1)
length: 318
go: ENSG00000215148;
snps: rs746540699
sequence:

opentargets:
anchored component of membrane [GO:0031225]; extracellular region [GO:0005576]; intracellular organelle [GO:0043229]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]

location:
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Note=Localized in the plasma membrane of spermatogonia. Localized in intracellular compartment in spermatocytes, probably in the Golgi apparatus (By similarity). {ECO:0000250}.


uniprotID: Q7Z5A4
geneSymbol: PRSS42
name: Serine protease 42 (EC 3.4.21.-) (Testis serine protease 2)
length: 293
go: ENSG00000178055;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:


uniprotID: Q7RTY3
geneSymbol: PRSS45
name: Serine protease 45 (EC 3.4.21.-) (Testis serine protease 5)
length: 260
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7RTY3-1; Sequence=Displayed; Name=2; IsoId=Q7RTY3-2; Sequence=VSP_035355; 


uniprotID: Q8IV56
geneSymbol: PRR15
name: Proline-rich protein 15
length: 129
go: ENSG00000176532;
opentargets: multicellular organism development [GO:0007275]
snps: rs10271996
sequence:
MADSGDAGSSGPWWKSLTNSRKKSKEAAVGVPPPAQPAPGEPTPPAPPSPDWTSSSRENQHPNLLGGAGEPPKPDKLYGDKSGSSRRNLKISRSGRFKEKRKVRATLLPEAGRSPEEAGFPGDPHEDKQ


uniprotID: O43272
geneSymbol: PRODH
reactome: R-HSA-70688;
length: 600
drug: DB06756;DB00172;
location: SUBCELLULAR LOCATION: Mitochondrion matrix.
name:
Proline dehydrogenase 1, mitochondrial (EC 1.5.5.2) (Proline oxidase) (Proline oxidase 2) (p53-induced gene 6 protein)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; FAD binding [GO:0071949]; proline dehydrogenase activity [GO:0004657]; 4-hydroxyproline catabolic process [GO:0019470]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of cell death [GO:0010942]; proline catabolic process [GO:0006562]; proline catabolic process to glutamate [GO:0010133]; proline metabolic process [GO:0006560]

snps:
rs2008720 rs4819756 rs3970555 rs2238731 rs2904552 rs2904551 rs3970559 rs1807467 rs2870984 rs2870983 rs450046 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O43272-4; Sequence=Displayed; Name=2; IsoId=O43272-2; Sequence=VSP_021848; Name=3; IsoId=O43272-1; Sequence=VSP_040848, VSP_040849; 


uniprotID: Q92786
geneSymbol: PROX1
pdb: 2LMD;
name: Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1)
length: 737
go: ENSG00000117707;
snps: rs12121210
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DBD domain binding [GO:0050692]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; LBD domain binding [GO:0050693]; nuclear receptor binding [GO:0016922]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; transcription regulatory region DNA binding [GO:0044212]; acinar cell differentiation [GO:0090425]; aorta smooth muscle tissue morphogenesis [GO:0060414]; atrial cardiac muscle tissue morphogenesis [GO:0055009]; brain development [GO:0007420]; branching involved in pancreas morphogenesis [GO:0061114]; cell fate determination [GO:0001709]; cerebellar granule cell differentiation [GO:0021707]; circadian rhythm [GO:0007623]; dentate gyrus development [GO:0021542]; dorsal spinal cord development [GO:0021516]; embryonic retina morphogenesis in camera-type eye [GO:0060059]; endocardium formation [GO:0060214]; hepatocyte cell migration [GO:0002194]; hepatocyte differentiation [GO:0070365]; hepatocyte proliferation [GO:0072574]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; lens fiber cell morphogenesis [GO:0070309]; liver development [GO:0001889]; lung development [GO:0030324]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; negative regulation of bile acid biosynthetic process [GO:0070858]; negative regulation of cell proliferation [GO:0008285]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral genome replication [GO:0045071]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; olfactory placode formation [GO:0030910]; optic placode formation involved in camera-type eye formation [GO:0046619]; otic placode formation [GO:0043049]; pancreas development [GO:0031016]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell cycle checkpoint [GO:1901978]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of forebrain neuron differentiation [GO:2000979]; positive regulation of heart growth [GO:0060421]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of sarcomere organization [GO:0060298]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of circadian rhythm [GO:0042752]; regulation of gene expression [GO:0010468]; regulation of transcription involved in lymphatic endothelial cell fate commitment [GO:0060849]; response to nutrient levels [GO:0031667]; retina morphogenesis in camera-type eye [GO:0060042]; skeletal muscle thin filament assembly [GO:0030240]; venous blood vessel morphogenesis [GO:0048845]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; ventricular cardiac myofibril assembly [GO:0055005]; ventricular septum morphogenesis [GO:0060412]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.


uniprotID: Q8WUY3
geneSymbol: PRUNE2
name: Protein prune homolog 2 (BNIP2 motif-containing molecule at the C-terminal region 1)
length: 3088
go: ENSG00000106772;
snps: rs375315668
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16288218}.
sequence:

opentargets:
cytoplasm [GO:0005737]; exopolyphosphatase activity [GO:0004309]; metal ion binding [GO:0046872]; apoptotic process [GO:0006915]; polyphosphate catabolic process [GO:0006798]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8WUY3-1; Sequence=Displayed; Name=2; IsoId=Q8WUY3-2; Sequence=VSP_039341; Name=3; Synonyms=BNIPXL-alpha; IsoId=Q8WUY3-3; Sequence=VSP_039341, VSP_039342; Name=4; Synonyms=BNIPXL-beta; IsoId=Q8WUY3-4; Sequence=VSP_039341, VSP_039342, VSP_039343; Name=5; IsoId=Q8WUY3-5; Sequence=VSP_039339, VSP_039340; 


uniprotID: P62191
geneSymbol: PSMC1
length: 440
go: ENSG00000100764;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-532668;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

pdb:
5GJQ;5GJR;5L4G;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHJ;5VHM;5VHN;5VHO;5VHP;5VHQ;5VHR;5VHS;

name:
26S proteasome regulatory subunit 4 (P26s4) (26S proteasome AAA-ATPase subunit RPT2) (Proteasome 26S subunit ATPase 1)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; RNA binding [GO:0003723]; TBP-class protein binding [GO:0017025]; negative regulation of neuron death [GO:1901215]; post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; protein folding [GO:0006457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P62191-1; Sequence=Displayed; Name=2; IsoId=P62191-2; Sequence=VSP_055768; Note=No experimental confirmation available.; 


uniprotID: Q96N64
geneSymbol: PWWP2A
name: PWWP domain-containing protein 2A
length: 755
go: ENSG00000170234;
opentargets: nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28645917}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96N64-1; Sequence=Displayed; Name=2; IsoId=Q96N64-2; Sequence=VSP_029547, VSP_029548; Name=3; IsoId=Q96N64-3; Sequence=VSP_054064, VSP_054065; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q14863
geneSymbol: POU6F1
pdb: 3D1N;
length: 301
location: SUBCELLULAR LOCATION: Nucleus.
name:
POU domain, class 6, transcription factor 1 (Brain-specific homeobox/POU domain protein 5) (Brain-5) (Brn-5) (mPOU homeobox protein)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; nuclear body [GO:0016604]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565]; brain development [GO:0007420]; heart development [GO:0007507]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]


uniprotID: Q9H237
geneSymbol: PORCN
reactome: R-HSA-3238698;R-HSA-5340573;
name: Protein-serine O-palmitoleoyltransferase porcupine (EC 2.3.1.-) (Protein MG61)
length: 461
go: ENSG00000102312;
snps: rs267606973
sequence:

opentargets:
AMPA glutamate receptor complex [GO:0032281]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glutamatergic synapse [GO:0098978]; integral component of endoplasmic reticulum membrane [GO:0030176]; palmitoleoyltransferase activity [GO:1990698]; Wnt-protein binding [GO:0017147]; canonical Wnt signaling pathway [GO:0060070]; glycoprotein metabolic process [GO:0009100]; protein lipidation [GO:0006497]; protein palmitoleylation [GO:0045234]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=D; IsoId=Q9H237-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9H237-2; Sequence=VSP_015888; Name=3; Synonyms=C; IsoId=Q9H237-3; Sequence=VSP_015887; Name=4; Synonyms=A; IsoId=Q9H237-4; Sequence=VSP_015886; Name=5; IsoId=Q9H237-5; Sequence=VSP_055419, VSP_015886; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JJJ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JJJ7}.


uniprotID: Q15166
geneSymbol: PON3
reactome: R-HSA-2142688;
name: Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1)
length: 354
go: ENSG00000105852;
drug: DB00974;DB00227;
snps: rs17878827 rs17883013
location: SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; 3,4-dihydrocoumarin hydrolase activity [GO:0018733]; acyl-L-homoserine-lactone lactonohydrolase activity [GO:0102007]; aryldialkylphosphatase activity [GO:0004063]; arylesterase activity [GO:0004064]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; aromatic compound catabolic process [GO:0019439]; carboxylic acid catabolic process [GO:0046395]; coumarin catabolic process [GO:0046226]; lipoxygenase pathway [GO:0019372]; negative regulation of superoxide anion generation [GO:0032929]; phenylacetate catabolic process [GO:0010124]; response to toxic substance [GO:0009636]


uniprotID: H3BUK9
geneSymbol: POTEB2
name: POTE ankyrin domain family member B2
length: 544
sequence:


uniprotID: A6NI47
geneSymbol: POTEM
name: Putative POTE ankyrin domain family member M
length: 508
go: ENSG00000222036;
sequence:


uniprotID: Q9UD71
geneSymbol: PPP1R1B
reactome: R-HSA-180024;
length: 204
go: ENSG00000131771;
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Protein phosphatase 1 regulatory subunit 1B (DARPP-32) (Dopamine- and cAMP-regulated neuronal phosphoprotein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine head [GO:0044327]; dendritic spine neck [GO:0044326]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; cAMP-dependent protein kinase inhibitor activity [GO:0004862]; D1 dopamine receptor binding [GO:0031748]; D2 dopamine receptor binding [GO:0031749]; D3 dopamine receptor binding [GO:0031750]; D4 dopamine receptor binding [GO:0031751]; D5 dopamine receptor binding [GO:0031752]; protein kinase inhibitor activity [GO:0004860]; protein phosphatase inhibitor activity [GO:0004864]; protein phosphatase regulator activity [GO:0019888]; behavioral response to cocaine [GO:0048148]; intracellular signal transduction [GO:0035556]; locomotory behavior [GO:0007626]; memory [GO:0007613]; negative regulation of female receptivity [GO:0007621]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; response to amphetamine [GO:0001975]; response to morphine [GO:0043278]; response to nicotine [GO:0035094]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]; visual learning [GO:0008542]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UD71-1; Sequence=Displayed; Name=2; Synonyms=t-DARPP; IsoId=Q9UD71-2; Sequence=VSP_005117; 


uniprotID: Q96S44
geneSymbol: TP53RK
reactome: R-HSA-6782315;R-HSA-6804756;
length: 253
go: ENSG00000172315;
snps: rs34983477 rs11550540 rs56008408
name:
EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; p53 binding [GO:0002039]; protein serine/threonine kinase activity [GO:0004674]; protein phosphorylation [GO:0006468]; regulation of signal transduction by p53 class mediator [GO:1901796]; tRNA processing [GO:0008033]; tRNA threonylcarbamoyladenosine metabolic process [GO:0070525]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:27903914, ECO:0000269|PubMed:28805828}.


uniprotID: P60891
geneSymbol: PRPS1
reactome: R-HSA-73843;
pdb: 2H06;2H07;2H08;2HCR;3EFH;3S5J;4F8E;4LYG;4LZN;4LZO;4M0P;4M0U;
length: 318
go: ENSG00000147224;
name:
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ribose phosphate diphosphokinase complex [GO:0002189]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; hypoxanthine biosynthetic process [GO:0046101]; nervous system development [GO:0007399]; nucleoside metabolic process [GO:0009116]; nucleotide biosynthetic process [GO:0009165]; purine nucleobase metabolic process [GO:0006144]; purine nucleotide biosynthetic process [GO:0006164]; pyrimidine nucleotide biosynthetic process [GO:0006221]; ribonucleoside monophosphate biosynthetic process [GO:0009156]; urate biosynthetic process [GO:0034418]

snps:
rs869025594 rs80338731 rs137852542 rs180177151 rs180177152 rs137852540 rs80338732 rs137852543 rs80338675 rs398122855 rs80338676 rs137852541 rs137852544 rs137852545 rs180177153 rs180177154 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P60891-1; Sequence=Displayed; Name=2; IsoId=P60891-2; Sequence=VSP_056028; Note=No experimental confirmation available.; 


uniprotID: Q9NV39
geneSymbol: PRR34
name: Proline-rich protein 34
length: 138
go: ENSG00000182257;
snps: rs12159707 rs59929908
sequence:
MPASATAAWHCPPLCLPPLPASAPTSPPNPATRPAPGPGRRARCPQSAHPAPTRGALTFWAPGSWPRVLLVPRSPGPVLRAPRLPHPAARARRRAWHGARLPGSPARAGRTFQRGLVSNSWAHAIFLPRPPNVLELQV


uniprotID: E7EML9
geneSymbol: PRSS44
name: Serine protease 44 (EC 3.4.21.-) (Testis serine protease 4) (TESSP-4)
length: 344
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; germ cell development [GO:0007281]; proteolysis [GO:0006508]; spermatogenesis [GO:0007283]


uniprotID: Q9UIG5
geneSymbol: PSORS1C1
name: Psoriasis susceptibility 1 candidate gene 1 protein (Protein SEEK1)
length: 152
go: ENSG00000204540;
snps: rs1265097 rs1265096 rs9263726 rs9501057 rs2233943 rs1063646
sequence:
MTCTDQKSHSQRALGTQTPALQGPQLLNTDPSSEETRPPHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UIG5-1; Sequence=Displayed; Name=2; IsoId=Q9UIG5-2; Sequence=VSP_009008; 


uniprotID: Q9UIG4
geneSymbol: PSORS1C2
name: Psoriasis susceptibility 1 candidate gene 2 protein (Protein SPR1)
length: 136
go: ENSG00000204538;
opentargets: extracellular region [GO:0005576]
snps: rs2233950 rs2233952
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPLFEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDNRPQEEPDLDPPREEYR


uniprotID: Q8WU10
geneSymbol: PYROXD1
name: Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC 1.8.1.-)
length: 500
go: ENSG00000121350;
snps: rs781565158 rs755208949
sequence:

opentargets:
nucleus [GO:0005634]; sarcomere [GO:0030017]; oxidoreductase activity [GO:0016491]; cellular response to oxidative stress [GO:0034599]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WU10-1; Sequence=Displayed; Name=2; IsoId=Q8WU10-2; Sequence=VSP_055828; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27745833}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:27745833}.


uniprotID: P11216
geneSymbol: PYGB
reactome: R-HSA-6798695;R-HSA-70221;
pdb: 5IKO;5IKP;
name: Glycogen phosphorylase, brain form (EC 2.4.1.1)
length: 843
go: ENSG00000100994;
drug: DB00114;
snps: rs2228976 rs2227891
sequence:

opentargets:
azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; glycogen catabolic process [GO:0005980]; neutrophil degranulation [GO:0043312]


uniprotID: Q9BU68
geneSymbol: PRR15L
name: Proline-rich protein 15-like protein (Protein ATAD4)
length: 103
go: ENSG00000167183;
sequence:
MTTEIGWWKLTFLRKKKSTPKVLYEIPDTYAQTEGDAEPPRPDAGGPNSDFNTRLEKIVDKSTKGKHVKVSNSGRFKEKKKVRATLAENPNLFDDHEEGRSSK


uniprotID: P86496
geneSymbol: PRR20A
name: Proline-rich protein 20A
length: 221
go: ENSG00000204919;
sequence:


uniprotID: P0DPQ3
geneSymbol: PRR20G
name: Proline-rich protein 20G
length: 210
sequence:


uniprotID: A6NEV1
geneSymbol: PRR23A
name: Proline-rich protein 23A
length: 266
sequence:


uniprotID: Q6ZRT6
geneSymbol: PRR23B
name: Proline-rich protein 23B
length: 265
sequence:


uniprotID: Q6ZRP0
geneSymbol: PRR23C
name: Proline-rich protein 23C
length: 262
go: ENSG00000233701;
sequence:


uniprotID: Q9ULD0
geneSymbol: OGDHL
length: 1010
go: ENSG00000197444;
snps: rs17856755 rs17852386 rs34877195 rs11101224 rs2293239
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
name:
2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; oxoglutarate dehydrogenase complex [GO:0045252]; metal ion binding [GO:0046872]; oxoglutarate dehydrogenase (succinyl-transferring) activity [GO:0004591]; thiamine pyrophosphate binding [GO:0030976]; glycolytic process [GO:0006096]; tricarboxylic acid cycle [GO:0006099]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9ULD0-1; Sequence=Displayed; Name=2; IsoId=Q9ULD0-2; Sequence=VSP_041350; Name=3; IsoId=Q9ULD0-3; Sequence=VSP_041351; 


uniprotID: Q8TAK6
geneSymbol: OLIG1
length: 271
go: ENSG00000184221;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
name:
Oligodendrocyte transcription factor 1 (Oligo1) (Class B basic helix-loop-helix protein 6) (bHLHb6) (Class E basic helix-loop-helix protein 21) (bHLHe21)

sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; neuron fate commitment [GO:0048663]; oligodendrocyte differentiation [GO:0048709]


uniprotID: Q6N063
geneSymbol: OGFOD2
name: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (EC 1.14.11.-)
length: 350
go: ENSG00000111325;
drug: DB00126;
sequence:

opentargets:
dioxygenase activity [GO:0051213]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [GO:0016705]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6N063-1; Sequence=Displayed; Name=2; IsoId=Q6N063-2; Sequence=VSP_025856, VSP_025857; Name=3; IsoId=Q6N063-3; Sequence=VSP_025858, VSP_025859; Note=No experimental confirmation available.; Name=4; IsoId=Q6N063-4; Sequence=VSP_025855; 


uniprotID: P08559
geneSymbol: PDHA1
reactome: R-HSA-204174;R-HSA-389661;R-HSA-5362517;R-HSA-70268;
pdb: 1NI4;2OZL;3EXE;3EXF;3EXG;3EXH;3EXI;6CER;6CFO;
length: 390
go: ENSG00000131828;
drug: DB00157;
location: SUBCELLULAR LOCATION: Mitochondrion matrix.
name:
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleolus [GO:0005730]; nucleus [GO:0005634]; pyruvate dehydrogenase complex [GO:0045254]; pyruvate dehydrogenase (acetyl-transferring) activity [GO:0004739]; pyruvate dehydrogenase (NAD+) activity [GO:0034604]; pyruvate dehydrogenase activity [GO:0004738]; acetyl-CoA biosynthetic process from pyruvate [GO:0006086]; glucose metabolic process [GO:0006006]; mitochondrial acetyl-CoA biosynthetic process from pyruvate [GO:0061732]; tricarboxylic acid cycle [GO:0006099]

snps:
rs137853257 rs863224148 rs138727886 rs866868610 rs137853254 rs794727843 rs1131691792 rs137853255 rs137853253 rs137853259 rs2229137 rs137853258 rs137853252 rs1064794149 rs137853256 rs2228067 rs137853250 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P08559-1; Sequence=Displayed; Name=2; IsoId=P08559-2; Sequence=VSP_042569; Note=No experimental confirmation available.; Name=3; IsoId=P08559-3; Sequence=VSP_042570; Note=No experimental confirmation available.; Name=4; IsoId=P08559-4; Sequence=VSP_043363; 


uniprotID: Q99983
geneSymbol: OMD
reactome: R-HSA-2022854;R-HSA-2022857;R-HSA-3656225;R-HSA-3656243;R-HSA-3656244;
pdb: 5YQ5;
name: Osteomodulin (Keratan sulfate proteoglycan osteomodulin) (KSPG osteomodulin) (Osteoadherin) (OSAD)
length: 421
go: ENSG00000127083;
snps: rs34069871 rs34413259 rs34860658 rs35779901 rs34059114
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; cell adhesion [GO:0007155]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate catabolic process [GO:0042340]; regulation of bone mineralization [GO:0030500]


uniprotID: O75915
geneSymbol: ARL6IP5
reactome: R-HSA-210500;
length: 188
go: ENSG00000144746;
name:
PRA1 family protein 3 (ADP-ribosylation factor-like protein 6-interacting protein 5) (ARL-6-interacting protein 5) (Aip-5) (Cytoskeleton-related vitamin A-responsive protein) (Dermal papilla-derived protein 11) (GTRAP3-18) (Glutamate transporter EAAC1-interacting protein) (JM5) (Prenylated Rab acceptor protein 2) (Protein JWa) (Putative MAPK-activating protein PM27)

sequence:
MDVNIAPLRAWDDFFPGSDRFARPDFRDISKWNNRVVSNLLYYQTNYLVVAAMMISIVGFLSPFNMILGGIVVVLVFTGFVWAAHNKDVLRRMKKRYPTTFVMVVMLASYFLISMFGGVMVFVFGITFPLLLMFIHASLRLRNLKNKLENKMEGIGLKRTPMGIVLDALEQQEEGINRLTDYISKVKE

opentargets:
cytoskeleton [GO:0005856]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; L-glutamate transmembrane transport [GO:0015813]; negative regulation of L-glutamate import across plasma membrane [GO:0002037]; negative regulation of mitochondrial membrane potential [GO:0010917]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of stress-activated MAPK cascade [GO:0032874]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9ES40}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ES40}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9ES40}. Note=Also exists as a soluble form in the cytoplasm. Associated with microtubules. {ECO:0000250|UniProtKB:Q9ES40}.


uniprotID: O60810
geneSymbol: PRAMEF4
name: PRAME family member 4
length: 478
go: ENSG00000243073;
snps: rs4625290
sequence:


uniprotID: Q5VWM4
geneSymbol: PRAMEF8
name: PRAME family member 8
length: 474
go: ENSG00000182330;
sequence:


uniprotID: Q04118
geneSymbol: PRB3
name: Basic salivary proline-rich protein 3 (Parotid salivary glycoprotein G1) (Proline-rich protein G1)
length: 309
opentargets: extracellular region [GO:0005576]; defense response to Gram-negative bacterium [GO:0050829]
snps: rs11054208
location: SUBCELLULAR LOCATION: Secreted.
sequence:


uniprotID: P0CE72
geneSymbol: OCM
pdb: 1TTX;
name: Oncomodulin-1 (OM) (Parvalbumin beta)
length: 109
go: ENSG00000122543;
sequence:
MSITDVLSADDIAAALQECRDPDTFEPQKFFQTSGLSKMSANQVKDVFRFIDNDQSGYLDEEELKFFLQKFESGARELTESETKSLMAAADNDGDGKIGAEEFQEMVHS

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; regulation of cytosolic calcium ion concentration [GO:0051480]


uniprotID: O60313
geneSymbol: OPA1
reactome: R-HSA-169911;
length: 960
go: ENSG00000198836;
name:
Dynamin-like 120 kDa protein, mitochondrial (EC 3.6.5.5) (Optic atrophy protein 1) [Cleaved into: Dynamin-like 120 kDa protein, form S1]

sequence:

opentargets:
axon cytoplasm [GO:1904115]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extrinsic component of mitochondrial inner membrane [GO:0031314]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial membrane [GO:0031966]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; cardiolipin binding [GO:1901612]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinase binding [GO:0019900]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; phosphatidic acid binding [GO:0070300]; apoptotic process [GO:0006915]; axonal transport of mitochondrion [GO:0019896]; calcium import into the mitochondrion [GO:0036444]; cellular response to glucose stimulus [GO:0071333]; cellular response to hypoxia [GO:0071456]; cellular response to L-glutamate [GO:1905232]; cellular senescence [GO:0090398]; cochlea development [GO:0090102]; dynamin family protein polymerization involved in mitochondrial fission [GO:0003374]; GTP metabolic process [GO:0046039]; inner mitochondrial membrane organization [GO:0007007]; intracellular distribution of mitochondria [GO:0048312]; membrane fusion [GO:0061025]; membrane tubulation [GO:0097749]; mitochondrial fission [GO:0000266]; mitochondrial fusion [GO:0008053]; mitochondrial genome maintenance [GO:0000002]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; positive regulation of dendritic spine morphogenesis [GO:0061003]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of mitochondrial fusion [GO:0010636]; positive regulation of neuron maturation [GO:0014042]; protein complex oligomerization [GO:0051259]; response to curcumin [GO:1904643]; response to electrical stimulus [GO:0051602]; response to muscle activity [GO:0014850]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]

snps:
rs794726939 rs151103940 rs201214736 rs530896300 rs7624750 rs34307082 rs121908375 rs780333963 rs28939082 rs770966290 rs190223702 rs780922750 rs143319805 rs727504060 rs879255594 rs387906900 rs80356529 rs869312995 rs398124298 rs879255592 rs140606054 rs121908376 rs147077380 rs778998909 rs190235251 rs1064797302 rs863224138 rs387906901 rs145710079 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist. {ECO:0000305|PubMed:11810270, ECO:0000305|PubMed:17709429}; Name=1; Synonyms=6; IsoId=O60313-1; Sequence=Displayed; Name=2; Synonyms=7 {ECO:0000303|PubMed:16778770}; IsoId=O60313-2; Sequence=VSP_021035; Note=Proteolytic processing near Gln-220 produces form S2 (Ref.9).; Name=3; IsoId=O60313-9; Sequence=VSP_059072, VSP_059074; Name=4; IsoId=O60313-10; Sequence=VSP_059073, VSP_059074; Note=Contains the alternative exon 4b that is important for mitochondrial genome maintenance.; Name=5; IsoId=O60313-11; Sequence=VSP_059073; Note=Contains the alternative exon 4b that is important for mitochondrial genome maintenance.; Name=7; IsoId=O60313-13; Sequence=VSP_059072; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11017079, ECO:0000269|PubMed:16778770, ECO:0000269|PubMed:20974897, ECO:0000269|PubMed:28746876}; Single-pass membrane protein {ECO:0000255}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P58281}. Mitochondrion membrane {ECO:0000269|PubMed:24616225}. Note=Detected at contact sites between endoplamic reticulum and mitochondrion membranes. {ECO:0000269|PubMed:24616225}.


uniprotID: O43749
geneSymbol: OR1F1
reactome: R-HSA-381753;
length: 312
go: ENSG00000168124;
snps: rs1834026 rs8045183
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 1F1 (Olfactory receptor 16-35) (OR16-35) (Olfactory receptor 1F10) (Olfactory receptor 1F4) (Olfactory receptor 1F5) (Olfactory receptor 1F6) (Olfactory receptor 1F7) (Olfactory receptor 1F8) (Olfactory receptor 1F9) (Olfactory receptor OR16-4)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]


uniprotID: Q8NGR2
geneSymbol: OR1L6
reactome: R-HSA-381753;
name: Olfactory receptor 1L6 (Olfactory receptor 1L7) (Olfactory receptor OR9-30)
length: 347
snps: rs10760252 rs4838012 rs10985760 rs10818741
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P41146
geneSymbol: OPRL1
reactome: R-HSA-375276;R-HSA-418594;
pdb: 4EA3;5DHG;5DHH;
name: Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)
length: 370
go: ENSG00000125510;
drug: DB05492;DB01497;
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; nociceptin receptor activity [GO:0001626]; protein C-terminus binding [GO:0008022]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of blood pressure [GO:0045776]; negative regulation of voltage-gated calcium channel activity [GO:1901386]; neuropeptide signaling pathway [GO:0007218]; opioid receptor signaling pathway [GO:0038003]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway [GO:0051482]; positive regulation of gastric acid secretion [GO:0060454]; positive regulation of sensory perception of pain [GO:1904058]; positive regulation of urine volume [GO:0035810]; regulation of locomotor rhythm [GO:1904059]; response to estradiol [GO:0032355]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P41146-1; Sequence=Displayed; Name=2; Synonyms=KOR-3D; IsoId=P41146-2; Sequence=VSP_001897; 

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.


uniprotID: Q9P1Q5
geneSymbol: OR1A1
reactome: R-HSA-381753;
name: Olfactory receptor 1A1 (Olfactory receptor 17-7) (OR17-7) (Olfactory receptor OR17-11)
length: 309
snps: rs4375699 rs17762735 rs769427
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9Y585
geneSymbol: OR1A2
reactome: R-HSA-381753;
name: Olfactory receptor 1A2 (Olfactory receptor 17-6) (OR17-6) (Olfactory receptor OR17-10)
length: 309
go: ENSG00000172150;
snps: rs56058341 rs2241091 rs2469791 rs12150427
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]


uniprotID: O95047
geneSymbol: OR2A4
reactome: R-HSA-381753;
name: Olfactory receptor 2A4 (Olfactory receptor 2A10) (Olfactory receptor OR6-37)
length: 310
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
cleavage furrow [GO:0032154]; Flemming body [GO:0090543]; integral component of membrane [GO:0016021]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cytokinesis [GO:0032467]; regulation of actin cytoskeleton organization [GO:0032956]


uniprotID: Q86XR5
geneSymbol: PRIMA1
name: Proline-rich membrane anchor 1 (PRiMA)
length: 153
go: ENSG00000175785;
sequence:
MLLRDLVLRRGCCWSSLLLHCALHPLWGFVQVTHGEPQKSCSKVTDSCRHVCQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPTEESWWSGLVIIIAVCCASLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSASQSNKGVDVNNAVV

opentargets:
cell junction [GO:0030054]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; synapse [GO:0045202]; neurotransmitter catabolic process [GO:0042135]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Variant I; IsoId=Q86XR5-1; Sequence=Displayed; Name=2; Synonyms=Variant II; IsoId=Q86XR5-2; Sequence=VSP_008494, VSP_008495; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=In the brain, PRIMA linked to ACHE is found in membrane rafts. {ECO:0000250}.


uniprotID: Q8NGB2
geneSymbol: OR4C5
reactome: R-HSA-381753;
name: Olfactory receptor 4C5 (Olfactory receptor OR11-99)
length: 326
go: ENSG00000176540;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: O76000
geneSymbol: OR2B3
reactome: R-HSA-381753;
length: 313
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Putative olfactory receptor 2B3 (Hs6M1-1) (Olfactory receptor OR6-14) (OR6-4) (Olfactory receptor 6-4)

sequence:


uniprotID: P17568
geneSymbol: NDUFB7
reactome: R-HSA-611105;R-HSA-6799198;
pdb: 5XTC;5XTD;5XTH;5XTI;
length: 137
go: ENSG00000099795;
drug: DB00157;
snps: rs3752220
name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 (Cell adhesion protein SQM1) (Complex I-B18) (CI-B18) (NADH-ubiquinone oxidoreductase B18 subunit)

sequence:
MGAHLVRRYLGDASVEPDPLQMPTFPPDYGFPERKEREMVATQQEMMDAQLRLQLRDYCAHHLIRLLKCKRDSFPNFLACKQERHDWDYCEHRDYVMRMKEFERERRLLQRKKRREKKAAELAKGQGPGEVDPKVAL

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial respiratory chain complex I [GO:0005747]; mitochondrion [GO:0005739]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; mitochondrial electron transport, NADH to ubiquinone [GO:0006120]; mitochondrial respiratory chain complex I assembly [GO:0032981]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21310150}; Peripheral membrane protein {ECO:0000269|PubMed:21310150}. Mitochondrion intermembrane space {ECO:0000269|PubMed:21310150}.


uniprotID: Q99574
geneSymbol: SERPINI1
pdb: 3F02;3F5N;3FGQ;
name: Neuroserpin (Peptidase inhibitor 12) (PI-12) (Serpin I1)
length: 410
go: ENSG00000163536;
snps: rs121909051
sequence:

opentargets:
cytoplasmic vesicle lumen [GO:0060205]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; perikaryon [GO:0043204]; secretory granule lumen [GO:0034774]; serine-type endopeptidase inhibitor activity [GO:0004867]; central nervous system development [GO:0007417]; negative regulation of endopeptidase activity [GO:0010951]; peripheral nervous system development [GO:0007422]; positive regulation of neuron projection development [GO:0010976]; regulation of cell adhesion [GO:0030155]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17040209}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000305|PubMed:17040209}. Perikaryon {ECO:0000269|PubMed:17040209}.


uniprotID: Q8NG66
geneSymbol: NEK11
length: 645
go: ENSG00000114670;
drug: DB08912;
name:
Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (Never in mitosis A-related kinase 11) (NimA-related protein kinase 11)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; histone phosphorylation [GO:0016572]; intra-S DNA damage checkpoint [GO:0031573]; intracellular signal transduction [GO:0035556]; mitotic cell cycle phase transition [GO:0044772]; protein phosphorylation [GO:0006468]; regulation of mitotic cell cycle phase transition [GO:1901990]

snps:
rs200709914 rs55806123 rs55920129 rs35567155 rs35409692 rs3738000 rs140599545 rs55813244 rs16836266 rs55944737 rs765563230 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:12154088}; Synonyms=Long {ECO:0000303|PubMed:12154088}; IsoId=Q8NG66-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12154088}; Synonyms=Short {ECO:0000303|PubMed:12154088}; IsoId=Q8NG66-2; Sequence=VSP_051821, VSP_051822; Name=3 {ECO:0000305}; IsoId=Q8NG66-3; Sequence=VSP_051820, VSP_051823; Note=No experimental confirmation available. {ECO:0000305}; Name=4; IsoId=Q8NG66-4; Sequence=VSP_040080, VSP_040081; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12154088}. Nucleus, nucleolus {ECO:0000269|PubMed:15161910}. Note=Nuclear during interphase but moves to the polar microtubules during prometaphase and metaphase (PubMed:12154088). Accumulates in the nucleolus in G1/S-arrested cells (PubMed:15161910). {ECO:0000269|PubMed:12154088, ECO:0000269|PubMed:15161910}.


uniprotID: Q9Y4A8
geneSymbol: NFE2L3
length: 694
go: ENSG00000050344;
snps: rs2072129
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
name:
Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; positive regulation of transcription, DNA-templated [GO:0045893]; transcription by RNA polymerase II [GO:0006366]


uniprotID: Q5M9Q1
geneSymbol: NKAPL
name: NKAP-like protein
length: 402
go: ENSG00000189134;
snps: rs12000 rs1635 rs9461446 rs1679709
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5SZT7}.
sequence:

opentargets:
nucleus [GO:0005634]; chromatin binding [GO:0003682]; cell differentiation [GO:0030154]; negative regulation of transcription, DNA-templated [GO:0045892]; Notch signaling pathway [GO:0007219]; spermatogenesis [GO:0007283]


uniprotID: P22307
geneSymbol: SCP2
reactome: R-HSA-193368;R-HSA-2046106;R-HSA-389887;R-HSA-9033241;R-HSA-9033500;
pdb: 1QND;2C0L;
length: 547
go: ENSG00000116171;
name:
Non-specific lipid-transfer protein (NSL-TP) (EC 2.3.1.176) (Propanoyl-CoA C-acyltransferase) (SCP-chi) (SCPX) (Sterol carrier protein 2) (SCP-2) (Sterol carrier protein X) (SCP-X)

sequence:

opentargets:
cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; cholesterol binding [GO:0015485]; fatty-acyl-CoA binding [GO:0000062]; long-chain fatty acyl-CoA binding [GO:0036042]; oleic acid binding [GO:0070538]; phosphatidylinositol transporter activity [GO:0008526]; propanoyl-CoA C-acyltransferase activity [GO:0033814]; propionyl-CoA C2-trimethyltridecanoyltransferase activity [GO:0050632]; signaling receptor binding [GO:0005102]; alpha-linolenic acid metabolic process [GO:0036109]; bile acid biosynthetic process [GO:0006699]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; inositol trisphosphate biosynthetic process [GO:0032959]; lipid hydroperoxide transport [GO:1901373]; phospholipid transport [GO:0015914]; positive regulation of intracellular cholesterol transport [GO:0032385]; positive regulation of steroid metabolic process [GO:0045940]; progesterone biosynthetic process [GO:0006701]; protein localization to plasma membrane [GO:0072659]; protein targeting to peroxisome [GO:0006625]; steroid biosynthetic process [GO:0006694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=8;  Name=SCPx; IsoId=P22307-1; Sequence=Displayed; Name=SCP2; IsoId=P22307-2; Sequence=VSP_018977; Note=Contains a mitochondrial transit peptide at positions 1-20. {ECO:0000305}; Name=3; IsoId=P22307-3; Sequence=VSP_042686, VSP_042687; Name=4; IsoId=P22307-4; Sequence=VSP_045187; Note=Produced by alternative splicing. No experimental confirmation available.; Name=5; IsoId=P22307-5; Sequence=VSP_018977, VSP_047269, VSP_047270; Name=6; IsoId=P22307-6; Sequence=VSP_018977, VSP_047268; Name=7; IsoId=P22307-7; Sequence=VSP_042686; Note=Produced by alternative splicing.; Name=8; IsoId=P22307-8; Sequence=VSP_047267; Note=Produced by alternative splicing.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17157249}. Mitochondrion {ECO:0000269|PubMed:17157249}. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.; SUBCELLULAR LOCATION: Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import.; SUBCELLULAR LOCATION: Isoform SCP2: Mitochondrion {ECO:0000305}.


uniprotID: Q969F2
geneSymbol: NKD2
name: Protein naked cuticle homolog 2 (Naked-2) (hNkd2)
length: 451
go: ENSG00000145506;
snps: rs35679233
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; exocytic vesicle [GO:0070382]; lateral plasma membrane [GO:0016328]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; growth factor binding [GO:0019838]; myosin heavy chain binding [GO:0032036]; ubiquitin protein ligase binding [GO:0031625]; exocytosis [GO:0006887]; Golgi vesicle fusion to target membrane [GO:0048210]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein processing [GO:0010954]; protein localization to plasma membrane [GO:0072659]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969F2-1; Sequence=Displayed; Name=2; IsoId=Q969F2-2; Sequence=VSP_027900, VSP_027901; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. Cytoplasm {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}. Cytoplasmic vesicle {ECO:0000269|PubMed:15064403, ECO:0000269|PubMed:17553928}.


uniprotID: P55058
geneSymbol: PLTP
reactome: R-HSA-8964058;
name: Phospholipid transfer protein (Lipid transfer protein II)
length: 493
go: ENSG00000100979;
snps: rs11569636 rs56126980 rs144710772 rs6065903 rs11569675 rs1804161 rs1056929
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; high-density lipoprotein particle [GO:0034364]; ceramide binding [GO:0097001]; ceramide transporter activity [GO:0035620]; diacylglycerol binding [GO:0019992]; lipid transporter activity [GO:0005319]; phosphatidic acid binding [GO:0070300]; phosphatidic acid transporter activity [GO:1990050]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylethanolamine transporter activity [GO:1904121]; phosphatidylglycerol binding [GO:1901611]; phospholipid transporter activity [GO:0005548]; ceramide transport [GO:0035627]; flagellated sperm motility [GO:0030317]; high-density lipoprotein particle remodeling [GO:0034375]; lipid metabolic process [GO:0006629]; lipid transport [GO:0006869]; phospholipid transport [GO:0015914]; positive regulation of cholesterol efflux [GO:0010875]; vitamin E biosynthetic process [GO:0010189]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P55058-1; Sequence=Displayed; Name=2; IsoId=P55058-2; Sequence=VSP_003050; Name=3; IsoId=P55058-3; Sequence=VSP_045877; Note=No experimental confirmation available.; Name=4; IsoId=P55058-4; Sequence=VSP_054028; Note=No experimental confirmation available.; 


uniprotID: P29474
geneSymbol: NOS3
reactome: R-HSA-1222556;R-HSA-1474151;R-HSA-203615;R-HSA-203641;R-HSA-203754;R-HSA-392154;R-HSA-5218920;
length: 1203
go: ENSG00000164867;
snps: rs3918166 rs1799983 rs145805216 rs145168353 rs7792133 rs3918232 rs3918201 rs3918234
pdb:
1M9J;1M9K;1M9M;1M9Q;1M9R;1NIW;2LL7;2MG5;2N8J;3EAH;3NOS;4D1O;4D1P;5UO8;5UO9;5UOA;5UOB;5UOC;5VVB;5VVC;5VVD;5XOF;6AV6;6AV7;

name:
Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII)

sequence:

opentargets:
caveola [GO:0005901]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle membrane [GO:0012506]; actin monomer binding [GO:0003785]; arginine binding [GO:0034618]; cadmium ion binding [GO:0046870]; calmodulin binding [GO:0005516]; flavin adenine dinucleotide binding [GO:0050660]; FMN binding [GO:0010181]; heme binding [GO:0020037]; NADP binding [GO:0050661]; NADPH-hemoprotein reductase activity [GO:0003958]; nitric-oxide synthase activity [GO:0004517]; oxidoreductase activity [GO:0016491]; scaffold protein binding [GO:0097110]; tetrahydrobiopterin binding [GO:0034617]; angiogenesis [GO:0001525]; aortic valve morphogenesis [GO:0003180]; arginine catabolic process [GO:0006527]; blood vessel remodeling [GO:0001974]; cell redox homeostasis [GO:0045454]; cofactor metabolic process [GO:0051186]; endocardial cushion morphogenesis [GO:0003203]; endothelial cell migration [GO:0043542]; homeostasis of number of cells within a tissue [GO:0048873]; in utero embryonic development [GO:0001701]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; lung development [GO:0030324]; mitochondrion organization [GO:0007005]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of blood pressure [GO:0045776]; negative regulation of calcium ion transport [GO:0051926]; negative regulation of cell proliferation [GO:0008285]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of hydrolase activity [GO:0051346]; negative regulation of muscle hyperplasia [GO:0014740]; negative regulation of platelet activation [GO:0010544]; negative regulation of potassium ion transport [GO:0043267]; nitric oxide biosynthetic process [GO:0006809]; nitric oxide mediated signal transduction [GO:0007263]; ovulation from ovarian follicle [GO:0001542]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of gene expression [GO:0010628]; positive regulation of guanylate cyclase activity [GO:0031284]; pulmonary valve morphogenesis [GO:0003184]; regulation of blood pressure [GO:0008217]; regulation of blood vessel size [GO:0050880]; regulation of nitric-oxide synthase activity [GO:0050999]; regulation of sodium ion transport [GO:0002028]; regulation of systemic arterial blood pressure by endothelin [GO:0003100]; regulation of the force of heart contraction by chemical signal [GO:0003057]; removal of superoxide radicals [GO:0019430]; response to fluid shear stress [GO:0034405]; response to heat [GO:0009408]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; smooth muscle hyperplasia [GO:0014806]; vasodilation [GO:0042311]; ventricular septum morphogenesis [GO:0060412]

drug:
DB02335;DB01997;DB04534;DB03100;DB02207;DB03065;DB05676;DB00997;DB07388;DB02234;DB02994;DB01833;DB00125;DB00155;DB03974;DB02077;DB01110;DB02044;DB04559;DB03144;DB02027;DB03305;DB04223;DB03963;DB03707;DB04018;DB00360;DB02589;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P29474-1; Sequence=Displayed; Name=eNOS13C; IsoId=P29474-2; Sequence=VSP_042625, VSP_042626; Note=Lacks eNOS activity.; Name=eNOS13B; IsoId=P29474-3; Sequence=VSP_045495, VSP_045496; 

location:
SUBCELLULAR LOCATION: Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.


uniprotID: P55209
geneSymbol: NAP1L1
name: Nucleosome assembly protein 1-like 1 (NAP-1-related protein) (hNRP)
length: 391
go: ENSG00000187109;
sequence:

opentargets:
cytoplasm [GO:0005737]; melanosome [GO:0042470]; membrane [GO:0016020]; nucleus [GO:0005634]; RNA binding [GO:0003723]; DNA replication [GO:0006260]; nucleosome assembly [GO:0006334]; positive regulation of cell proliferation [GO:0008284]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P55209-1; Sequence=Displayed; Name=2; IsoId=P55209-2; Sequence=VSP_053909; Note=No experimental confirmation available.; Name=3; IsoId=P55209-3; Sequence=VSP_057357, VSP_057358; Note=No experimental confirmation available. {ECO:0000244|PubMed:22814378}; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm {ECO:0000250|UniProtKB:P28656}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.


uniprotID: O75051
geneSymbol: PLXNA2
reactome: R-HSA-399954;R-HSA-399955;R-HSA-399956;R-HSA-416700;
pdb: 3Q3J;
name: Plexin-A2 (Semaphorin receptor OCT)
length: 1894
go: ENSG00000076356;
snps: rs2782948 rs11119014 rs3748735 rs4844658 rs17011882 rs12240051
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; semaphorin receptor complex [GO:0002116]; identical protein binding [GO:0042802]; semaphorin receptor activity [GO:0017154]; centrosome localization [GO:0051642]; cerebellar granule cell precursor tangential migration [GO:0021935]; limb bud formation [GO:0060174]; negative regulation of cell adhesion [GO:0007162]; neural tube development [GO:0021915]; pharyngeal system development [GO:0060037]; positive regulation of axonogenesis [GO:0050772]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; semaphorin-plexin signaling pathway [GO:0071526]; semaphorin-plexin signaling pathway involved in axon guidance [GO:1902287]; somitogenesis [GO:0001756]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75051-1; Sequence=Displayed; Name=2; IsoId=O75051-2; Sequence=VSP_017967, VSP_017968, VSP_017969; 


uniprotID: Q99733
geneSymbol: NAP1L4
name: Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2)
length: 375
go: ENSG00000205531;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; unfolded protein binding [GO:0051082]; nucleosome assembly [GO:0006334]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99733-1; Sequence=Displayed; Name=2; Synonyms=NAP1L4b {ECO:0000303|Ref.2}; IsoId=Q99733-2; Sequence=VSP_053910; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}. Cytoplasm {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}. Note=Present in the cytoplasm and excluded from the nucleus during G0/G1 phase, then relocates to the nucleus by the time cells are in S phase (PubMed:9325046). Phosphorylated form localizes in the cytoplasm during the G0/G1 transition, whereas dephosphorylation leads to relocalization into the nucleus at the G1/S-boundary (PubMed:10764593). {ECO:0000269|PubMed:10764593, ECO:0000269|PubMed:9325046}.


uniprotID: P48745
geneSymbol: NOV
length: 357
go: ENSG00000136999;
drug: DB00030;DB00071;
snps: rs2279112 rs11538929
name:
Protein NOV homolog (NovH) (CCN family member 3) (Insulin-like growth factor-binding protein 9) (IBP-9) (IGF-binding protein 9) (IGFBP-9) (Nephroblastoma-overexpressed gene protein homolog)

sequence:

opentargets:
axon [GO:0030424]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; gap junction [GO:0005921]; intracellular membrane-bounded organelle [GO:0043231]; neuronal cell body [GO:0043025]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; insulin-like growth factor binding [GO:0005520]; integrin binding [GO:0005178]; Notch binding [GO:0005112]; angiogenesis [GO:0001525]; bone regeneration [GO:1990523]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell chemotaxis [GO:0060326]; chondrocyte differentiation [GO:0002062]; endothelial cell chemotaxis [GO:0035767]; endothelial cell-cell adhesion [GO:0071603]; fibroblast migration [GO:0010761]; hematopoietic stem cell homeostasis [GO:0061484]; negative regulation of cell death [GO:0060548]; negative regulation of cell growth [GO:0030308]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin secretion [GO:0046676]; negative regulation of monocyte chemotaxis [GO:0090027]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of sensory perception of pain [GO:1904057]; negative regulation of SMAD protein signal transduction [GO:0060392]; positive regulation of Notch signaling pathway [GO:0045747]; regulation of gene expression [GO:0010468]; smooth muscle cell migration [GO:0014909]; smooth muscle cell proliferation [GO:0048659]; type B pancreatic cell proliferation [GO:0044342]

location:
SUBCELLULAR LOCATION: Secreted. Cytoplasm {ECO:0000269|PubMed:15181016}. Cell junction, gap junction {ECO:0000269|PubMed:15181016}. Note=Localizes at the Gap junction in presence of GJA1/CX43. {ECO:0000250|UniProtKB:Q9QZQ5}.


uniprotID: Q96NT1
geneSymbol: NAP1L5
name: Nucleosome assembly protein 1-like 5 (Down-regulated in liver malignancy)
length: 182
go: ENSG00000177432;
opentargets: nucleus [GO:0005634]; nucleosome assembly [GO:0006334]
snps: rs13109442
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:
MADSENQGPAEPSQAAAAAEAAAEEVMAEGGAQGGDCDSAAGDPDSAAGQMAEEPQTPAENAPKPKNDFIESLPNSVKCRVLALKKLQKRCDKIEAKFDKEFQALEKKYNDIYKPLLAKIQELTGEMEGCAWTLEGEEEEEEEYEDDEEEGEDEEEEEAAAEAAAGAKHDDAHAEMPDDAKK


uniprotID: Q14207
geneSymbol: NPAT
length: 1427
go: ENSG00000149308;
name:
Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220)

sequence:

opentargets:
Cajal body [GO:0015030]; cytoplasm [GO:0005737]; Gemini of coiled bodies [GO:0097504]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein C-terminus binding [GO:0008022]; protein N-terminus binding [GO:0047485]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of gene expression [GO:0010468]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]

snps:
rs1131748 rs1051521 rs35504388 rs968207 rs4144901 rs2070661 rs35095430 rs1051522 rs1131750 rs1131751 rs1051524 rs34052882 rs1051525 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, Cajal body. Note=Concentrates in two Cajal bodies tethered to histone gene clusters at chromosome 6p21 during G1, S and G2 phases. Also concentrates in two additional Cajal bodies tethered to histone gene clusters at chromosome 1q21 specifically during S and G2 phases.


uniprotID: Q96L73
geneSymbol: NSD1
reactome: R-HSA-3214841;
pdb: 3OOI;
length: 2696
go: ENSG00000165671;
location: SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000305}.
name:
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (H4-K20-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein)

sequence:

opentargets:
chromosome [GO:0005694]; nucleoplasm [GO:0005654]; androgen receptor binding [GO:0050681]; chromatin binding [GO:0003682]; estrogen receptor binding [GO:0030331]; histone methyltransferase activity (H3-K36 specific) [GO:0046975]; histone methyltransferase activity (H4-K20 specific) [GO:0042799]; histone-lysine N-methyltransferase activity [GO:0018024]; retinoic acid receptor binding [GO:0042974]; retinoid X receptor binding [GO:0046965]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; thyroid hormone receptor binding [GO:0046966]; transcription coregulator activity [GO:0003712]; transcription corepressor activity [GO:0003714]; zinc ion binding [GO:0008270]; histone methylation [GO:0016571]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of histone H3-K36 methylation [GO:0000414]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903025]

snps:
rs3733875 rs28932177 rs28932178 rs28932179 rs35597015 rs587784169 rs797045825 rs587784174 rs587784177 rs587784176 rs121908068 rs121908069 rs35848863 rs34165241 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=ARA267-beta; IsoId=Q96L73-1; Sequence=Displayed; Name=2; Synonyms=ARA267-alpha; IsoId=Q96L73-2; Sequence=VSP_007682, VSP_007683; Name=3; IsoId=Q96L73-3; Sequence=VSP_007684; 


uniprotID: O96028
geneSymbol: NSD2
reactome: R-HSA-3214841;R-HSA-5693565;R-HSA-5693571;R-HSA-5693607;R-HSA-69473;
pdb: 5LSU;5VC8;
length: 1365
go: ENSG00000109685;
name:
Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.43) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)

sequence:

opentargets:
chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone methyltransferase activity (H4-K20 specific) [GO:0042799]; histone-lysine N-methyltransferase activity [GO:0018024]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; anatomical structure morphogenesis [GO:0009653]; atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; bone development [GO:0060348]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone H3-K36 methylation [GO:0010452]; membranous septum morphogenesis [GO:0003149]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of double-strand break repair via nonhomologous end joining [GO:2001032]; regulation of establishment of protein localization [GO:0070201]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=O96028-1; Sequence=Displayed; Name=2; IsoId=O96028-2; Sequence=VSP_021414, VSP_021423; Name=3; IsoId=O96028-3; Sequence=VSP_021419, VSP_021422; Name=4; Synonyms=RE-IIBP, IL-5 promoter REII-region-binding protein; IsoId=O96028-4; Sequence=VSP_021413; Name=5; IsoId=O96028-5; Sequence=VSP_021420, VSP_021421; Name=6; IsoId=O96028-6; Sequence=VSP_021417, VSP_021418; Note=No experimental confirmation available.; Name=7; IsoId=O96028-7; Sequence=VSP_021415, VSP_021416; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:15677557, ECO:0000269|PubMed:16197452}. Chromosome {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.


uniprotID: P46459
geneSymbol: NSF
reactome: R-HSA-204005;R-HSA-416993;R-HSA-6807878;R-HSA-6811434;R-HSA-6811438;R-HSA-6811440;
length: 744
go: ENSG00000073969;
snps: rs155733
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Vesicle-fusing ATPase (EC 3.6.4.6) (N-ethylmaleimide-sensitive fusion protein) (NEM-sensitive fusion protein) (Vesicular-fusion protein NSF)

sequence:

opentargets:
cytosol [GO:0005829]; dendritic shaft [GO:0043198]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; lysosomal membrane [GO:0005765]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, coupled [GO:0042623]; ionotropic glutamate receptor binding [GO:0035255]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; Rab GTPase binding [GO:0017137]; SNARE binding [GO:0000149]; syntaxin-1 binding [GO:0017075]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi vesicle docking [GO:0048211]; intracellular protein transport [GO:0006886]; plasma membrane fusion [GO:0045026]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of receptor recycling [GO:0001921]; potassium ion transport [GO:0006813]; regulation of exocytosis [GO:0017157]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; SNARE complex disassembly [GO:0035494]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P46459-1; Sequence=Displayed; Name=2; IsoId=P46459-2; Sequence=VSP_056420, VSP_056421; Note=No experimental confirmation available.; 


uniprotID: Q86YG4
geneSymbol: NT5DC4
name: 5'-nucleotidase domain-containing protein 4
length: 428
opentargets: 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]
sequence:


uniprotID: Q08J23
geneSymbol: NSUN2
reactome: R-HSA-6782315;
length: 767
go: ENSG00000037474;
snps: rs2303708 rs587776908
name:
tRNA (cytosine(34)-C(5))-methyltransferase (EC 2.1.1.203) (Myc-induced SUN domain-containing protein) (Misu) (NOL1/NOP2/Sun domain family member 2) (Substrate of AIM1/Aurora kinase B) (tRNA (cytosine-5-)-methyltransferase) (tRNA methyltransferase 4 homolog) (hTrm4)

sequence:

opentargets:
chromatoid body [GO:0033391]; cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; methyltransferase activity [GO:0008168]; RNA binding [GO:0003723]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]; cell division [GO:0051301]; hair follicle maturation [GO:0048820]; meiotic cell cycle checkpoint [GO:0033313]; spermatid development [GO:0007286]; tRNA methylation [GO:0030488]; tRNA modification [GO:0006400]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q08J23-1; Sequence=Displayed; Name=2; IsoId=Q08J23-2; Sequence=VSP_042621; Note=No experimental confirmation available.; Name=3; IsoId=Q08J23-3; Sequence=VSP_053598; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Note=Concentrated in the nucleolus during interphase and translocates to the spindle during mitosis as an RNA-protein complex that includes 18S ribosomal RNA.


uniprotID: O95665
geneSymbol: NTSR2
reactome: R-HSA-375276;R-HSA-416476;
name: Neurotensin receptor type 2 (NT-R-2) (NTR2) (Levocabastine-sensitive neurotensin receptor)
length: 410
go: ENSG00000169006;
drug: DB01106;
snps: rs6432225 rs34764121
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; regulation of membrane potential [GO:0042391]; sensory perception [GO:0007600]


uniprotID: Q8TCD5
geneSymbol: NT5C
reactome: R-HSA-73621;R-HSA-74259;
pdb: 2I7D;4L57;4YIH;6G2N;
length: 201
go: ENSG00000125458;
drug: DB00709;
snps: rs11541956
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
5'(3')-deoxyribonucleotidase, cytosolic type (EC 3.1.3.-) (Cytosolic 5',3'-pyrimidine nucleotidase) (Deoxy-5'-nucleotidase 1) (dNT-1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; 5'-nucleotidase activity [GO:0008253]; metal ion binding [GO:0046872]; nucleotidase activity [GO:0008252]; pyrimidine nucleotide binding [GO:0019103]; dephosphorylation [GO:0016311]; purine nucleotide catabolic process [GO:0006195]; pyrimidine deoxyribonucleotide catabolic process [GO:0009223]; pyrimidine nucleoside catabolic process [GO:0046135]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TCD5-1; Sequence=Displayed; Name=2; IsoId=Q8TCD5-2; Sequence=VSP_008710, VSP_008711, VSP_008712; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: O76050
geneSymbol: NEURL1
reactome: R-HSA-2122948;R-HSA-2644606;R-HSA-2691232;R-HSA-2894862;R-HSA-2979096;R-HSA-9013507;
length: 574
go: ENSG00000107954;
name:
E3 ubiquitin-protein ligase NEURL1 (EC 2.3.2.27) (Neuralized-like protein 1A) (h-neu) (h-neuralized 1) (RING finger protein 67) (RING-type E3 ubiquitin transferase NEURL1)

sequence:

opentargets:
apical dendrite [GO:0097440]; cell junction [GO:0030054]; dendritic spine [GO:0043197]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; metal ion binding [GO:0046872]; translation factor activity, non-nucleic acid binding [GO:0045183]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; brain development [GO:0007420]; cellular response to amino acid stimulus [GO:0071230]; lactation [GO:0007595]; negative regulation of cell proliferation [GO:0008285]; negative regulation of Notch signaling pathway [GO:0045746]; nervous system development [GO:0007399]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic process [GO:0043065]; positive regulation of dendritic spine development [GO:0060999]; positive regulation of epidermal growth factor-activated receptor activity [GO:0045741]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of long-term neuronal synaptic plasticity [GO:0048170]; positive regulation of synapse maturation [GO:0090129]; protein monoubiquitination [GO:0006513]; skeletal muscle tissue development [GO:0007519]; sperm axoneme assembly [GO:0007288]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O76050-1; Sequence=Displayed; Name=2; IsoId=O76050-2; Sequence=VSP_013151; Note=Gene prediction confirmed by EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11585928, ECO:0000269|PubMed:20847082}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity). Colocalized with JAG1 at the cell surface. {ECO:0000250}.


uniprotID: Q5T2W1
geneSymbol: PDZK1
pdb: 2EEI;2EEJ;2VSP;3TMH;4Q2P;6EZI;
length: 519
go: ENSG00000174827;
name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; extracellular exosome [GO:0070062]; membrane raft [GO:0045121]; microvillus membrane [GO:0031528]; plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]; protein-containing complex binding [GO:0044877]; scavenger receptor binding [GO:0005124]; transporter activity [GO:0005215]; carnitine transport [GO:0015879]; cell proliferation [GO:0008283]; drug transport [GO:0015893]; positive regulation of cation transmembrane transport [GO:1904064]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of anion transport [GO:0044070]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T2W1-1; Sequence=Displayed; Name=2; IsoId=Q5T2W1-2; Sequence=VSP_044637; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9JJ40}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000250|UniProtKB:Q9JIL4}. Note=Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes. {ECO:0000250|UniProtKB:Q9JJ40}.


uniprotID: Q9NX24
geneSymbol: NHP2
reactome: R-HSA-171319;R-HSA-6790901;
length: 153
go: ENSG00000145912;
snps: rs139588879 rs121908090 rs121908089
name:
H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)

sequence:
MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQSLPLPL

opentargets:
box H/ACA scaRNP complex [GO:0072589]; box H/ACA snoRNP complex [GO:0031429]; box H/ACA telomerase RNP complex [GO:0090661]; nuclear chromosome, telomeric region [GO:0000784]; nucleoplasm [GO:0005654]; small nucleolar ribonucleoprotein complex [GO:0005732]; telomerase holoenzyme complex [GO:0005697]; box H/ACA snoRNA binding [GO:0034513]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; cleavage involved in rRNA processing [GO:0000469]; maturation of LSU-rRNA [GO:0000470]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; rRNA pseudouridine synthesis [GO:0031118]; snRNA pseudouridine synthesis [GO:0031120]; telomere maintenance via telomerase [GO:0007004]; translation [GO:0006412]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).


uniprotID: Q6T4R5
geneSymbol: NHS
name: Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein)
length: 1651
go: ENSG00000188158;
snps: rs3747295 rs2071848 rs2071848
sequence:

opentargets:
apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nuclear body [GO:0016604]; cell differentiation [GO:0030154]; lens development in camera-type eye [GO:0002088]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=NHS-A; IsoId=Q6T4R5-1; Sequence=Displayed; Name=2; IsoId=Q6T4R5-2; Sequence=VSP_046541; Name=3; Synonyms=NHS-1A; IsoId=Q6T4R5-3; Sequence=VSP_046537, VSP_046540; Name=4; IsoId=Q6T4R5-4; Sequence=VSP_046538, VSP_046539, VSP_046540; 

location:
SUBCELLULAR LOCATION: Isoform 1: Apical cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell junction, tight junction. Cell junction, focal adhesion. Note=Colocalizes with the tight junction protein TJP1 in epithelial cells. Localizes to the leading edge of lamellipodia in motile cells.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.


uniprotID: Q76FK4
geneSymbol: NOL8
name: Nucleolar protein 8 (Nucleolar protein Nop132)
length: 1167
go: ENSG00000198000;
snps: rs58545014 rs2236344 rs15717 rs34224798 rs921122
sequence:

opentargets:
nucleolus [GO:0005730]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; protein localization to nucleolus [GO:1902570]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000269|PubMed:14660641, ECO:0000269|PubMed:15132771}; IsoId=Q76FK4-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15164053}; IsoId=Q76FK4-2; Sequence=VSP_052055; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=4 {ECO:0000269|PubMed:15164053}; IsoId=Q76FK4-4; Sequence=VSP_052056; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15132771, ECO:0000269|PubMed:16963496}. Note=Localizes in the nucleolar-organizing region during ribosome biogenesis.


uniprotID: Q9UK39
geneSymbol: NOCT
reactome: R-HSA-1368108;
pdb: 6BT1;6BT2;6MAL;
name: Nocturnin (EC 3.1.13.4) (Carbon catabolite repression 4-like protein) (Circadian deadenylase NOC)
length: 431
go: ENSG00000151014;
snps: rs2271777
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perinuclear region of cytoplasm [GO:0048471]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; poly(A)-specific ribonuclease activity [GO:0004535]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of gene expression [GO:0010629]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of fat cell differentiation [GO:0045600]; regulation of circadian rhythm [GO:0042752]; regulation of embryonic development [GO:0045995]; response to extracellular stimulus [GO:0009991]; response to lipopolysaccharide [GO:0032496]; transcription by RNA polymerase II [GO:0006366]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.


uniprotID: Q9BZQ4
geneSymbol: NMNAT2
reactome: R-HSA-196807;
length: 307
go: ENSG00000157064;
name:
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 (NMN/NaMN adenylyltransferase 2) (EC 2.7.7.1) (EC 2.7.7.18) (Nicotinamide mononucleotide adenylyltransferase 2) (NMN adenylyltransferase 2) (Nicotinate-nucleotide adenylyltransferase 2) (NaMN adenylyltransferase 2)

sequence:

opentargets:
axon [GO:0030424]; cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome [GO:0005770]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; ATP binding [GO:0005524]; nicotinamide-nucleotide adenylyltransferase activity [GO:0000309]; nicotinate-nucleotide adenylyltransferase activity [GO:0004515]; 'de novo' NAD biosynthetic process from aspartate [GO:0034628]; NAD biosynthetic process [GO:0009435]; NAD metabolic process [GO:0019674]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BZQ4-1; Sequence=Displayed; Name=2; IsoId=Q9BZQ4-2; Sequence=VSP_015571; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16118205}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8BNJ3}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BNJ3}. Cytoplasm {ECO:0000269|PubMed:16118205}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BNJ3}. Note=Delivered to axons with Golgi-derived cytoplasmic vesicles. {ECO:0000250|UniProtKB:Q8BNJ3}.


uniprotID: Q99742
geneSymbol: NPAS1
length: 590
go: ENSG00000130751;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
name:
Neuronal PAS domain-containing protein 1 (Neuronal PAS1) (Basic-helix-loop-helix-PAS protein MOP5) (Class E basic helix-loop-helix protein 11) (bHLHe11) (Member of PAS protein 5) (PAS domain-containing protein 5)

sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; central nervous system development [GO:0007417]; maternal behavior [GO:0042711]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; startle response [GO:0001964]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99742-1; Sequence=Displayed; Name=2; IsoId=Q99742-2; Sequence=VSP_054280, VSP_054281, VSP_054282; Note=No experimental confirmation available.; 


uniprotID: Q86UR1
geneSymbol: NOXA1
reactome: R-HSA-5668599;
length: 476
go: ENSG00000188747;
snps: rs34155071
name:
NADPH oxidase activator 1 (NOX activator 1) (Antigen NY-CO-31) (NCF2-like protein) (P67phox-like factor) (p51-nox)

sequence:

opentargets:
cytosol [GO:0005829]; NADPH oxidase complex [GO:0043020]; enzyme binding [GO:0019899]; Rac GTPase binding [GO:0048365]; SH3 domain binding [GO:0017124]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide metabolic process [GO:0006801]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86UR1-1; Sequence=Displayed; Name=2; IsoId=Q86UR1-2; Sequence=VSP_030336; Note=Mostly inactive for NOX1 activation. Does not interact with NOXO1.; Name=3; Synonyms=NOXA1inhib; IsoId=Q86UR1-3; Sequence=VSP_030335, VSP_030336; Note=Inactive for NOX1 activation. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1.


uniprotID: Q8NFA2
geneSymbol: NOXO1
reactome: R-HSA-5668599;
pdb: 2L73;
length: 376
go: ENSG00000196408;
drug: DB05265;
name:
NADPH oxidase organizer 1 (NADPH oxidase regulatory protein) (Nox organizer 1) (Nox-organizing protein 1) (SH3 and PX domain-containing protein 5)

sequence:

opentargets:
NADPH oxidase complex [GO:0043020]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; phosphatidylinositol binding [GO:0035091]; phospholipid binding [GO:0005543]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; extracellular matrix disassembly [GO:0022617]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of respiratory burst [GO:0060263]; superoxide metabolic process [GO:0006801]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=NOXO1gamma; IsoId=Q8NFA2-1; Sequence=Displayed; Name=2; Synonyms=NOXO1delta; IsoId=Q8NFA2-2; Sequence=VSP_017560; Name=3; Synonyms=NOXO1beta; IsoId=Q8NFA2-3; Sequence=VSP_017561; Name=4; Synonyms=NOXO1alpha; IsoId=Q8NFA2-4; Sequence=VSP_017560, VSP_017561; 

location:
SUBCELLULAR LOCATION: Isoform 3: Cell membrane {ECO:0000269|PubMed:12716910}; Peripheral membrane protein {ECO:0000269|PubMed:12716910}; Cytoplasmic side {ECO:0000269|PubMed:12716910}. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).


uniprotID: Q9NY59
geneSymbol: SMPD3
reactome: R-HSA-1660662;R-HSA-5626978;
pdb: 5UVG;
length: 655
go: ENSG00000103056;
drug: DB00144;
name:
Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II)

sequence:

opentargets:
Golgi cis cisterna [GO:0000137]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; cell cycle [GO:0007049]; hematopoietic progenitor cell differentiation [GO:0002244]; peptide hormone secretion [GO:0030072]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of exosomal secretion [GO:1903543]; sphingomyelin catabolic process [GO:0006685]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NY59-1; Sequence=Displayed; Name=2; IsoId=Q9NY59-2; Sequence=VSP_054334; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10823942}; Lipid-anchor {ECO:0000269|PubMed:10823942}. Cell membrane {ECO:0000269|PubMed:15051724}; Lipid-anchor {ECO:0000269|PubMed:15051724}. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons (PubMed:10823942). Localizes to plasma membrane in confluent contact-inhaibited cells (PubMed:15051724).


uniprotID: Q96MG7
geneSymbol: NSMCE3
reactome: R-HSA-3108214;
pdb: 5HVQ;5WY5;
length: 304
go: ENSG00000185115;
snps: rs886037827 rs199905054
name:
Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2)

sequence:

opentargets:
chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; Smc5-Smc6 complex [GO:0030915]; protein dimerization activity [GO:0046983]; cellular response to hydroxyurea [GO:0072711]; cellular response to radiation [GO:0071478]; cellular response to UV [GO:0034644]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; positive regulation of protein ubiquitination [GO:0031398]; regulation of growth [GO:0040008]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.


uniprotID: O60906
geneSymbol: SMPD2
reactome: R-HSA-1660662;R-HSA-193681;R-HSA-5626978;
length: 423
go: ENSG00000135587;
snps: rs1048197 rs9386806 rs1476387
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase)

sequence:

opentargets:
caveola [GO:0005901]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; sphingomyelin phosphodiesterase activity [GO:0004767]; ceramide biosynthetic process [GO:0046513]; intracellular signal transduction [GO:0035556]; positive regulation of ceramide biosynthetic process [GO:2000304]; response to mechanical stimulus [GO:0009612]; sphingomyelin metabolic process [GO:0006684]


uniprotID: Q9BZ95
geneSymbol: NSD3
reactome: R-HSA-3214841;
pdb: 2DAQ;2NCZ;2ND1;4GND;4GNE;4GNF;4GNG;4RXJ;5UPD;6CEN;
length: 1437
go: ENSG00000147548;
snps: rs13034 rs2234552
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
name:
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.43) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)

sequence:

opentargets:
chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone-lysine N-methyltransferase activity [GO:0018024]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; histone methylation [GO:0016571]; positive regulation of histone H3-K36 trimethylation [GO:2001255]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9BZ95-1; Sequence=Displayed; Name=2; IsoId=Q9BZ95-2; Sequence=VSP_021430; Name=3; IsoId=Q9BZ95-3; Sequence=VSP_021428, VSP_021429; Name=4; IsoId=Q9BZ95-4; Sequence=VSP_021427; Note=No experimental confirmation available.; Name=5; IsoId=Q9BZ95-5; Sequence=VSP_054489; Note=No experimental confirmation available.; 


uniprotID: P30989
geneSymbol: NTSR1
reactome: R-HSA-375276;R-HSA-416476;
pdb: 2LYW;
length: 418
go: ENSG00000101188;
snps: rs11698783 rs35373650 rs2273075
name:
Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)

sequence:

opentargets:
cell surface [GO:0009986]; cytoplasmic side of plasma membrane [GO:0009898]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; symmetric synapse [GO:0032280]; terminal bouton [GO:0043195]; G protein-coupled neurotensin receptor activity [GO:0016492]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein N-terminus binding [GO:0047485]; adult locomotory behavior [GO:0008344]; chemical synaptic transmission [GO:0007268]; D-aspartate import across plasma membrane [GO:0070779]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; inositol phosphate catabolic process [GO:0071545]; L-glutamate import across plasma membrane [GO:0098712]; learning [GO:0007612]; negative regulation of apoptotic process [GO:0043066]; negative regulation of release of sequestered calcium ion into cytosol [GO:0051280]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of apoptotic process [GO:0043065]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cation channel activity [GO:2001259]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of action potential [GO:0098900]; regulation of membrane depolarization [GO:0003254]; regulation of respiratory gaseous exchange [GO:0043576]; regulation of sensory perception of pain [GO:0051930]; response to lipid [GO:0033993]; temperature homeostasis [GO:0001659]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8381365}; Multi-pass membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21725197}. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts. {ECO:0000269|PubMed:21725197}.


uniprotID: Q5TYX0
geneSymbol: PRAMEF5
name: PRAME family member 5
length: 476
go: ENSG00000270601;
sequence:


uniprotID: P13725
geneSymbol: OSM
reactome: R-HSA-6785807;R-HSA-6788467;
pdb: 1EVS;
name: Oncostatin-M (OSM)
length: 252
go: ENSG00000099985;
snps: rs5763919
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; oncostatin-M receptor binding [GO:0005147]; cell proliferation [GO:0008283]; cytokine-mediated signaling pathway [GO:0019221]; immune response [GO:0006955]; multicellular organism development [GO:0007275]; negative regulation of cell proliferation [GO:0008285]; negative regulation of hormone secretion [GO:0046888]; oncostatin-M-mediated signaling pathway [GO:0038165]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-17 secretion [GO:1905078]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; regulation of growth [GO:0040008]


uniprotID: O43663
geneSymbol: PRC1
reactome: R-HSA-5625900;
pdb: 3NRX;3NRY;4L3I;4L6Y;5KMG;
name: Protein regulator of cytokinesis 1
length: 620
go: ENSG00000198901;
snps: rs7172758 rs12911192
sequence:

opentargets:
contractile ring [GO:0070938]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle microtubule [GO:0005876]; spindle pole [GO:0000922]; identical protein binding [GO:0042802]; kinesin binding [GO:0019894]; microtubule binding [GO:0008017]; protein kinase binding [GO:0019901]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; mitotic spindle elongation [GO:0000022]; positive regulation of cell proliferation [GO:0008284]; regulation of cytokinesis [GO:0032465]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:9885575}; IsoId=O43663-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=O43663-2; Sequence=VSP_051979, VSP_051980; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648}; Name=3; IsoId=O43663-3; Sequence=VSP_035875, VSP_035876; Note=No experimental confirmation available.; Name=4; IsoId=O43663-4; Sequence=VSP_051980; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648}; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17409436}. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody {ECO:0000269|PubMed:17409436}. Note=Colocalized with KIF20B in the nucleus of bladder carcinoma cells at the interphase. Colocalized with KIF20B in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). Predominantly localized to the nucleus of interphase cells. During mitosis becomes associated with the mitotic spindle poles and localizes with the cell midbody during cytokinesis. {ECO:0000269|PubMed:17409436}.


uniprotID: Q6U736
geneSymbol: OPN5
reactome: R-HSA-418594;R-HSA-419771;
length: 354
go: ENSG00000124818;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Opsin-5 (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Neuropsin) (Transmembrane protein 13)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601]


uniprotID: Q9Y520
geneSymbol: PRRC2C
length: 2896
go: ENSG00000117523;
name:
Protein PRRC2C (BAT2 domain-containing protein 1) (HBV X-transactivated gene 2 protein) (HBV XAg-transactivated protein 2) (HLA-B-associated transcript 2-like 2) (Proline-rich and coiled-coil-containing protein 2C)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; protein C-terminus binding [GO:0008022]; RNA binding [GO:0003723]; hematopoietic progenitor cell differentiation [GO:0002244]

snps:
rs10913157 rs36013361 rs704839 rs760644 rs34269512 rs235468 rs1687056 rs3820169 rs12025905 rs183523 rs2421847 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q9Y520-1; Sequence=Displayed; Name=2; IsoId=Q9Y520-2; Sequence=VSP_035244; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y520-3; Sequence=VSP_035247, VSP_035248; Name=4; IsoId=Q9Y520-4; Sequence=VSP_035249; Note=No experimental confirmation available.; Name=5; IsoId=Q9Y520-5; Sequence=VSP_035245; Note=No experimental confirmation available.; Name=6; IsoId=Q9Y520-6; Sequence=VSP_035246, VSP_035249; Note=No experimental confirmation available.; Name=7; IsoId=Q9Y520-7; Sequence=VSP_035250; Note=No experimental confirmation available.; 


uniprotID: Q8NGR3
geneSymbol: OR1K1
reactome: R-HSA-381753;
name: Olfactory receptor 1K1
length: 316
snps: rs7046603
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q7Z3G6
geneSymbol: PRICKLE2
name: Prickle-like protein 2
length: 844
go: ENSG00000163637;
snps: rs387906988 rs139747674 rs387906989
location: SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000305}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; zinc ion binding [GO:0008270]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]


uniprotID: Q15612
geneSymbol: OR1Q1
reactome: R-HSA-381753;
length: 314
snps: rs972925 rs1329957 rs727913
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 1Q1 (OST226) (Olfactory receptor 1Q2) (Olfactory receptor 1Q3) (Olfactory receptor 9-A) (OR9-A) (Olfactory receptor OR9-25) (Olfactory receptor TPCR106)

sequence:


uniprotID: P0DN78
geneSymbol: OPN1MW3
length: 364
go: ENSG00000268221;
name:
Medium-wave-sensitive opsin 3 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP) (opsin 1 cone pigments medium-wave-sensitive 3)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; photoreceptor outer segment [GO:0001750]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: P30953
geneSymbol: OR1E1
reactome: R-HSA-381753;
length: 314
snps: rs1735011 rs150989 rs379856
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 1E1 (Olfactory receptor 13-66) (OR13-66) (Olfactory receptor 17-2/17-32) (OR17-2) (OR17-32) (Olfactory receptor 1E5) (Olfactory receptor 1E6) (Olfactory receptor 5-85) (OR5-85) (Olfactory receptor OR17-18) (Olfactory receptor-like protein HGMP07I)

sequence:


uniprotID: Q8NH72
geneSymbol: OR4C6
reactome: R-HSA-381753;
name: Olfactory receptor 4C6 (Olfactory receptor OR11-138)
length: 309
go: ENSG00000181903;
snps: rs11230600
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96R27
geneSymbol: OR2M4
reactome: R-HSA-381753;
name: Olfactory receptor 2M4 (HTPCRX18) (OST710) (Olfactory receptor OR1-55) (Olfactory receptor TPCR100)
length: 311
go: ENSG00000171180;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGM1
geneSymbol: OR4C15
reactome: R-HSA-381753;
name: Olfactory receptor 4C15 (Olfactory receptor OR11-127) (Olfactory receptor OR11-134)
length: 316
go: ENSG00000181939;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NG81
geneSymbol: OR2M7
reactome: R-HSA-381753;
name: Olfactory receptor 2M7 (Olfactory receptor OR1-58)
length: 312
go: ENSG00000177186;
snps: rs7555424 rs7555310 rs4916130 rs4916129
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P0C626
geneSymbol: OR5G3
reactome: R-HSA-381753;
name: Olfactory receptor 5G3 (Olfactory receptor 5G6) (Olfactory receptor OR11-213)
length: 314
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P58180
geneSymbol: OR4D2
reactome: R-HSA-381753;
name: Olfactory receptor 4D2 (B-lymphocyte membrane protein BC2009) (Olfactory receptor OR17-24)
length: 307
go: ENSG00000255713;
snps: rs60994383
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGE8
geneSymbol: OR4D9
reactome: R-HSA-381753;
name: Olfactory receptor 4D9 (Olfactory receptor OR11-253)
length: 314
go: ENSG00000172742;
snps: rs17501584
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NHB8
geneSymbol: OR5K2
reactome: R-HSA-381753;
name: Olfactory receptor 5K2 (Olfactory receptor OR3-9)
length: 316
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P0C645
geneSymbol: OR4E1
reactome: R-HSA-381753;
name: Olfactory receptor 4E1 (Olfactory receptor OR14-43)
length: 315
go: ENSG00000276240;
snps: rs10143044 rs970025 rs7144135
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGC2
geneSymbol: OR4E2
reactome: R-HSA-381753;
name: Olfactory receptor 4E2 (Olfactory receptor OR14-42)
length: 313
snps: rs2874103 rs970382
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P0C7T2
geneSymbol: OR2T7
reactome: R-HSA-381753;
name: Olfactory receptor 2T7 (OST723) (olfactory receptor OR1-44)
length: 308
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: A6NH00
geneSymbol: OR2T8
reactome: R-HSA-381753;
name: Olfactory receptor 2T8
length: 312
snps: rs11204563 rs11204564 rs28575687 rs4584426 rs4474294 rs4362017 rs6695357 rs58882030
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGP8
geneSymbol: OR5M1
reactome: R-HSA-381753;
name: Olfactory receptor 5M1 (OST050) (Olfactory receptor OR11-208)
length: 315
snps: rs4939078
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96R30
geneSymbol: OR2V2
reactome: R-HSA-381753;
name: Olfactory receptor 2V2 (Olfactory receptor 2V3) (Olfactory receptor OR5-3)
length: 315
go: ENSG00000182613;
snps: rs17617270 rs2546423
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGP3
geneSymbol: OR5M9
reactome: R-HSA-381753;
name: Olfactory receptor 5M9 (Olfactory receptor OR11-190)
length: 310
snps: rs1945237
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q6IEU7
geneSymbol: OR5M10
reactome: R-HSA-381753;
name: Olfactory receptor 5M10 (Olfactory receptor OR11-207)
length: 315
snps: rs10792043 rs10896488
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96RB7
geneSymbol: OR5M11
reactome: R-HSA-381753;
name: Olfactory receptor 5M11
length: 305
go: ENSG00000255223;
snps: rs628524 rs17547207
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NG97
geneSymbol: OR2Z1
reactome: R-HSA-381753;
name: Olfactory receptor 2Z1 (Olfactory receptor 2Z2) (Olfactory receptor OR19-4)
length: 314
go: ENSG00000181733;
snps: rs58741481
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH85
geneSymbol: OR5R1
reactome: R-HSA-381753;
name: Olfactory receptor 5R1 (Olfactory receptor OR11-185)
length: 324
go: ENSG00000279961;
snps: rs7931261 rs7123108 rs7111634 rs6591324 rs7933772 rs17150578 rs12785840 rs7930678 rs998544
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: O76099
geneSymbol: OR7C1
reactome: R-HSA-381753;
length: 320
go: ENSG00000127530;
snps: rs17230134 rs10415562 rs10415312 rs16979912
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 7C1 (Olfactory receptor 7C4) (Olfactory receptor OR19-16) (Olfactory receptor TPCR86)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; G protein-coupled receptor signaling pathway [GO:0007186]; spermatogenesis [GO:0007283]


uniprotID: Q8NGD1
geneSymbol: OR4N2
reactome: R-HSA-381753;
name: Olfactory receptor 4N2 (Olfactory receptor OR14-13) (Olfactory receptor OR14-8)
length: 307
snps: rs2801164 rs2318279 rs17114261
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH69
geneSymbol: OR5W2
reactome: R-HSA-381753;
name: Olfactory receptor 5W2 (Olfactory receptor 5W3) (Olfactory receptor OR11-155)
length: 310
snps: rs17511797 rs12419022 rs17596519 rs17148883 rs2457239 rs17596422 rs34573569
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGL7
geneSymbol: OR4P4
reactome: R-HSA-381753;
name: Olfactory receptor 4P4 (Olfactory receptor 4P3)
length: 312
go: ENSG00000181927;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P59922
geneSymbol: OR2B8P
reactome: R-HSA-381753;
name: Putative olfactory receptor 2B8 (Hs6M1-29P)
length: 312
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NG95
geneSymbol: OR7G3
reactome: R-HSA-381753;
name: Olfactory receptor 7G3 (OST085) (Olfactory receptor OR19-9)
length: 312
go: ENSG00000170920;
snps: rs10414255
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P47893
geneSymbol: OR3A2
reactome: R-HSA-381753;
name: Olfactory receptor 3A2 (Olfactory receptor 17-228) (OR17-228) (Olfactory receptor OR17-14)
length: 321
go: ENSG00000221882;
snps: rs9901356
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signaling receptor activity [GO:0038023]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of chemical stimulus [GO:0007606]; signal transduction [GO:0007165]


uniprotID: P47888
geneSymbol: OR3A3
reactome: R-HSA-381753;
length: 321
go: ENSG00000159961;
snps: rs769432 rs916039 rs12939997 rs227787
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 3A3 (Olfactory receptor 17-201) (OR17-201) (Olfactory receptor 3A6) (Olfactory receptor 3A7) (Olfactory receptor 3A8) (Olfactory receptor OR17-22)

sequence:


uniprotID: P0C7N8
geneSymbol: OR9G9
reactome: R-HSA-381753;
name: Olfactory receptor 9G9
length: 305
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGI9
geneSymbol: OR5A2
reactome: R-HSA-381753;
name: Olfactory receptor 5A2 (Olfactory receptor OR11-248)
length: 324
go: ENSG00000172324;
snps: rs17153691 rs1453547
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96R08
geneSymbol: OR5B12
reactome: R-HSA-381753;
name: Olfactory receptor 5B12 (Olfactory receptor 5B16) (Olfactory receptor OR11-241)
length: 314
snps: rs4938895 rs11229457
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGG7
geneSymbol: OR8A1
reactome: R-HSA-381753;
name: Olfactory receptor 8A1 (OST025) (Olfactory receptor OR11-318)
length: 326
go: ENSG00000196119;
snps: rs55861866 rs12792184
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGR4
geneSymbol: OR5C1
reactome: R-HSA-381753;
name: Olfactory receptor 5C1 (Olfactory receptor 5C2) (Olfactory receptor 9-F) (OR9-F)
length: 320
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGU4
geneSymbol: OR2I1P
reactome: R-HSA-381753;
length: 316
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Putative olfactory receptor 2I1 (Putative olfactory receptor 2I2) (Putative olfactory receptor 2I3) (Putative olfactory receptor 2I4)

sequence:


uniprotID: Q9GZK6
geneSymbol: OR2J1
reactome: R-HSA-381753;
name: Olfactory receptor 2J1 (Hs6M1-4) (Olfactory receptor 6-5) (OR6-5)
length: 312
snps: rs3131087
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: A6NF89
geneSymbol: OR6C6
reactome: R-HSA-381753;
name: Olfactory receptor 6C6
length: 314
snps: rs11171402
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGC5
geneSymbol: OR6J1
reactome: R-HSA-381753;
name: Olfactory receptor 6J1 (Olfactory receptor 6J2)
length: 347
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8WZ84
geneSymbol: OR8D1
reactome: R-HSA-381753;
length: 308
go: ENSG00000196341;
snps: rs2510433 rs7107539 rs4936919
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 8D1 (OST004) (Olfactory receptor 8D3) (Olfactory receptor OR11-301) (Olfactory receptor-like protein JCG9)

sequence:


uniprotID: Q8NGN8
geneSymbol: OR4A4P
reactome: R-HSA-381753;
name: Putative olfactory receptor 4A4 (Olfactory receptor OR11-107)
length: 299
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGM9
geneSymbol: OR8D4
reactome: R-HSA-381753;
name: Olfactory receptor 8D4 (Olfactory receptor OR11-275)
length: 314
snps: rs17127947 rs17127950 rs10750250 rs7926767 rs10790610 rs12270203 rs7942047 rs7927385
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGW6
geneSymbol: OR6K6
reactome: R-HSA-381753;
name: Olfactory receptor 6K6 (Olfactory receptor OR1-21)
length: 343
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

snps:
rs16840974 rs16840976 rs16840980 rs16840991 rs16841001 rs16841009 rs16841017 rs16841038 rs16841042 rs16841045 


uniprotID: Q8NGF8
geneSymbol: OR4B1
reactome: R-HSA-381753;
name: Olfactory receptor 4B1 (OST208) (Olfactory receptor OR11-106)
length: 309
go: ENSG00000175619;
snps: rs11606506 rs12292056
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGY6
geneSymbol: OR6N2
reactome: R-HSA-381753;
name: Olfactory receptor 6N2 (Olfactory receptor OR1-23)
length: 317
go: ENSG00000188340;
snps: rs12027473 rs41273541
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8N0Y5
geneSymbol: OR8I2
reactome: R-HSA-381753;
name: Olfactory receptor 8I2 (Olfactory receptor OR11-170)
length: 310
go: ENSG00000172154;
snps: rs17603011 rs17150021
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P04156
geneSymbol: PRNP
reactome: R-HSA-419037;
name: Major prion protein (PrP) (ASCR) (PrP27-30) (PrP33-35C) (CD antigen CD230)
length: 253
go: ENSG00000171867;
drug: DB00759;
pdb:
1E1G;1E1J;1E1P;1E1S;1E1U;1E1W;1FKC;1FO7;1H0L;1HJM;1HJN;1I4M;1OEH;1OEI;1QLX;1QLZ;1QM0;1QM1;1QM2;1QM3;2IV4;2IV5;2IV6;2K1D;2KUN;2LBG;2LEJ;2LFT;2LSB;2LV1;2M8T;2OL9;2W9E;3HAF;3HAK;3HEQ;3HER;3HES;3HJ5;3HJX;3MD4;3MD5;3NHC;3NHD;3NVF;4DGI;4E1H;4E1I;4KML;4N9O;5L6R;5YJ4;5YJ5;

sequence:

opentargets:
anchored component of external side of plasma membrane [GO:0031362]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; Golgi apparatus [GO:0005794]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; amyloid-beta binding [GO:0001540]; ATP-dependent protein binding [GO:0043008]; chaperone binding [GO:0051087]; copper ion binding [GO:0005507]; cupric ion binding [GO:1903135]; cuprous ion binding [GO:1903136]; glycosaminoglycan binding [GO:0005539]; identical protein binding [GO:0042802]; ion channel binding [GO:0044325]; lamin binding [GO:0005521]; microtubule binding [GO:0008017]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; signaling receptor activity [GO:0038023]; tubulin binding [GO:0015631]; type 5 metabotropic glutamate receptor binding [GO:0031802]; activation of protein kinase activity [GO:0032147]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell cycle arrest [GO:0007050]; cellular copper ion homeostasis [GO:0006878]; cellular response to amyloid-beta [GO:1904646]; cellular response to copper ion [GO:0071280]; cellular response to drug [GO:0035690]; dendritic spine maintenance [GO:0097062]; learning or memory [GO:0007611]; long-term memory [GO:0007616]; modulation of age-related behavioral decline [GO:0090647]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of catalytic activity [GO:0043086]; negative regulation of dendritic spine maintenance [GO:1902951]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of long-term synaptic potentiation [GO:1900272]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of protein processing [GO:0010955]; negative regulation of T cell receptor signaling pathway [GO:0050860]; neuron projection maintenance [GO:1990535]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of neuron death [GO:1901216]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of protein tyrosine kinase activity [GO:0061098]; protein destabilization [GO:0031648]; protein homooligomerization [GO:0051260]; regulation of calcium ion import across plasma membrane [GO:1905664]; regulation of glutamate receptor signaling pathway [GO:1900449]; regulation of intracellular calcium activated chloride channel activity [GO:1902938]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; regulation of potassium ion transmembrane transport [GO:1901379]; response to amyloid-beta [GO:1904645]; response to cadmium ion [GO:0046686]; response to oxidative stress [GO:0006979]

snps:
rs74315401 rs11538758 rs74315402 rs267606980 rs1799990 rs74315410 rs16990018 rs74315403 rs74315408 rs74315411 rs74315413 rs372878791 rs74315405 rs28933385 rs761807915 rs776593792 rs74315412 rs74315407 rs398122370 rs751882709 rs74315406 rs1800014 rs74315409 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=3;  Name=1; Synonyms=PrP; IsoId=P04156-1; Sequence=Displayed; Name=2; Synonyms=PrP(M8); IsoId=P04156-2; Sequence=VSP_039045; Name=3; Synonyms=AltPrP; IsoId=F7VJQ1-1; Sequence=External; 

location:
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19936054}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000269|PubMed:19936054}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:19059915}. Nucleus {ECO:0000269|PubMed:19059915}. Note=Accumulates outside the secretory route in the cytoplasm, from where it relocates to the nucleus. {ECO:0000269|PubMed:19059915}.


uniprotID: P0C7N1
geneSymbol: OR8U8
reactome: R-HSA-381753;
name: Olfactory receptor 8U8
length: 319
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P0C7N5
geneSymbol: OR8U9
reactome: R-HSA-381753;
name: Olfactory receptor 8U9
length: 309
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9Y619
geneSymbol: SLC25A15
reactome: R-HSA-70635;
name: Mitochondrial ornithine transporter 1 (Solute carrier family 25 member 15)
length: 301
go: ENSG00000102743;
drug: DB00129;
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; L-ornithine transmembrane transporter activity [GO:0000064]; mitochondrial L-ornithine transmembrane transport [GO:1990575]; urea cycle [GO:0000050]

snps:
rs1208994024 rs104894430 rs121908533 rs1064793683 rs121908534 rs199894905 rs104894424 rs141028076 rs202247804 rs1417167600 rs17849654 rs121908535 rs202247808 rs104894431 rs202247809 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0G2K309}.


uniprotID: P0C024
geneSymbol: NUDT7
reactome: R-HSA-390918;R-HSA-9033241;
pdb: 5T3P;
length: 238
go: ENSG00000140876;
snps: rs308925 rs16946429
location: SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
name:
Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)

sequence:

opentargets:
cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; acetyl-CoA hydrolase activity [GO:0003986]; CoA hydrolase activity [GO:0016289]; hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [GO:0016818]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; signaling receptor binding [GO:0005102]; snoRNA binding [GO:0030515]; acetyl-CoA catabolic process [GO:0046356]; brown fat cell differentiation [GO:0050873]; coenzyme A catabolic process [GO:0015938]; fatty acid catabolic process [GO:0009062]; nucleoside diphosphate metabolic process [GO:0009132]; protein targeting to peroxisome [GO:0006625]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P0C024-1; Sequence=Displayed; Name=2; IsoId=P0C024-2; Sequence=VSP_047605; Name=3; IsoId=P0C024-3; Sequence=VSP_053820, VSP_053821; Note=Gene prediction based on EST data.; 


uniprotID: Q9UHM6
geneSymbol: OPN4
reactome: R-HSA-416476;R-HSA-419771;
name: Melanopsin (Opsin-4)
length: 478
go: ENSG00000122375;
snps: rs2675703 rs1079610 rs12262894
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; photoreceptor disc membrane [GO:0097381]; 11-cis retinal binding [GO:0005502]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UHM6-1; Sequence=Displayed; Name=2; IsoId=Q9UHM6-2; Sequence=VSP_041123; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Found in soma, dendrites and proximal part of axons of certain retinal ganglion cells. {ECO:0000250}.


uniprotID: O14841
geneSymbol: OPLAH
reactome: R-HSA-174403;R-HSA-5578998;
name: 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)
length: 1288
go: ENSG00000178814;
drug: DB00142;
snps: rs3935209
sequence:

opentargets:
cytosol [GO:0005829]; 5-oxoprolinase (ATP-hydrolyzing) activity [GO:0017168]; ATP binding [GO:0005524]; glutathione biosynthetic process [GO:0006750]; glutathione metabolic process [GO:0006749]


uniprotID: Q9NQV6
geneSymbol: PRDM10
pdb: 3IHX;
name: PR domain zinc finger protein 10 (EC 2.1.1.-) (PR domain-containing protein 10) (Tristanin)
length: 1147
go: ENSG00000170325;
snps: rs11221912 rs2241571
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyltransferase activity [GO:0008168]; regulation of gene expression [GO:0010468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=3; IsoId=Q9NQV6-3; Sequence=Displayed; Name=2; IsoId=Q9NQV6-2; Sequence=VSP_036351, VSP_035655, VSP_035656; Name=1; IsoId=Q9NQV6-1; Sequence=VSP_036351; Name=4; IsoId=Q9NQV6-4; Sequence=VSP_035655, VSP_036352; Note=No experimental confirmation available.; Name=5; IsoId=Q9NQV6-5; Sequence=VSP_036351, VSP_036352; Note=No experimental confirmation available.; Name=6; IsoId=Q9NQV6-6; Sequence=VSP_035655, VSP_036352, VSP_036353; Note=No experimental confirmation available.; Name=7; IsoId=Q9NQV6-7; Sequence=VSP_036352; Note=No experimental confirmation available.; 


uniprotID: P03999
geneSymbol: OPN1SW
reactome: R-HSA-2187335;R-HSA-2453864;R-HSA-418594;R-HSA-419771;
pdb: 1KPN;
name: Short-wave-sensitive opsin 1 (Blue cone photoreceptor pigment) (Blue-sensitive opsin) (BOP)
length: 348
go: ENSG00000128617;
snps: rs104894031 rs104894032 rs104894033
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; G protein-coupled photoreceptor activity [GO:0008020]; signaling receptor activity [GO:0038023]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; retinoid metabolic process [GO:0001523]; signal transduction [GO:0007165]; visual perception [GO:0007601]


uniprotID: Q8NGS2
geneSymbol: OR1J2
reactome: R-HSA-381753;
length: 313
go: ENSG00000197233;
snps: rs41277120 rs4836891
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 1J2 (HSA5) (HTPCRX15) (OST044) (Olfactory receptor 1J3) (Olfactory receptor 1J5) (Olfactory receptor OR9-19)

sequence:


uniprotID: Q8NH93
geneSymbol: OR1L3
reactome: R-HSA-381753;
name: Olfactory receptor 1L3 (Olfactory receptor 9-D) (OR9-D) (Olfactory receptor OR9-28)
length: 324
snps: rs12379744 rs16912096 rs16912099
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: O14718
geneSymbol: RRH
reactome: R-HSA-418594;R-HSA-419771;
name: Visual pigment-like receptor peropsin
length: 337
go: ENSG00000180245;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; photoreceptor outer segment [GO:0001750]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601]


uniprotID: Q8NH92
geneSymbol: OR1S1
reactome: R-HSA-381753;
name: Olfactory receptor 1S1 (Olfactory receptor OR11-232)
length: 325
snps: rs1966836 rs1966835 rs1966834 rs1993088 rs2867400 rs2903566
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P0DN77
geneSymbol: OPN1MW2
length: 364
go: ENSG00000268221;
name:
Medium-wave-sensitive opsin 2 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP) (Opsin 1 cone pigments medium-wave-sensitive 2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; photoreceptor outer segment [GO:0001750]; G protein-coupled photoreceptor activity [GO:0008020]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q8NGT9
geneSymbol: OR2A1; OR2A42
reactome: R-HSA-381753;
name: Olfactory receptor 2A1/2A42 (Olfactory receptor OR7-16) (Olfactory receptor OR7-19)
length: 310
go: ENSG00000212807;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q6IF42
geneSymbol: OR2A2
reactome: R-HSA-381753;
name: Olfactory receptor 2A2 (Olfactory receptor 2A17) (Olfactory receptor OR7-11)
length: 318
snps: rs10230228 rs10252253 rs2961149
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96R45
geneSymbol: OR2A7
reactome: R-HSA-381753;
name: Olfactory receptor 2A7 (Olfactory receptor OR7-18)
length: 310
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH37
geneSymbol: OR4C3
reactome: R-HSA-381753;
name: Olfactory receptor 4C3 (Olfactory receptor OR11-98)
length: 302
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96R28
geneSymbol: OR2M2
reactome: R-HSA-381753;
name: Olfactory receptor 2M2 (OST423)
length: 347
snps: rs61156873 rs4244171 rs4916104 rs9435890
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q6IEV9
geneSymbol: OR4C11
reactome: R-HSA-381753;
name: Olfactory receptor 4C11 (Olfactory receptor OR11-136)
length: 310
snps: rs491160 rs11230346 rs2456022
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96R67
geneSymbol: OR4C12
reactome: R-HSA-381753;
name: Olfactory receptor 4C12 (Olfactory receptor OR11-259)
length: 309
go: ENSG00000221954;
snps: rs4598671
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGL9
geneSymbol: OR4C16
reactome: R-HSA-381753;
name: Olfactory receptor 4C16 (Olfactory receptor OR11-135)
length: 310
snps: rs12800642 rs558465 rs557590 rs12288690 rs559449
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9NQN1
geneSymbol: OR2S2
reactome: R-HSA-381753;
name: Olfactory receptor 2S2 (Olfactory receptor OR9-3)
length: 319
snps: rs2233558 rs2233559 rs2233560 rs2233563 rs2233564 rs2233565 rs2233570
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGV6
geneSymbol: OR5H6
reactome: R-HSA-381753;
name: Olfactory receptor 5H6 (Olfactory receptor OR3-11)
length: 325
snps: rs4241472 rs2173236 rs2173236 rs9289564 rs16846784 rs9853887 rs9853906 rs9871143
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGJ1
geneSymbol: OR4D6
reactome: R-HSA-381753;
name: Olfactory receptor 4D6 (Olfactory receptor OR11-250)
length: 314
go: ENSG00000166884;
snps: rs17153766 rs1453544 rs1453543 rs17153770 rs17500380 rs1453542 rs1453541
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH03
geneSymbol: OR2T3
reactome: R-HSA-381753;
name: Olfactory receptor 2T3
length: 318
go: ENSG00000196539;
snps: rs1770110
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGI6
geneSymbol: OR4D10
reactome: R-HSA-381753;
name: Olfactory receptor 4D10 (Olfactory receptor OR11-251)
length: 311
go: ENSG00000254466;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q6IEZ7
geneSymbol: OR2T5
reactome: R-HSA-381753;
name: Olfactory receptor 2T5 (Olfactory receptor OR1-62)
length: 315
snps: rs1770043
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NHC8
geneSymbol: OR2T6
reactome: R-HSA-381753;
name: Olfactory receptor 2T6 (OST703) (Olfactory receptor 2T9)
length: 308
snps: rs7417616 rs6587467 rs6693032 rs6701129 rs954475
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGL2
geneSymbol: OR5L1
reactome: R-HSA-381753;
name: Olfactory receptor 5L1 (OST262) (Olfactory receptor OR11-151)
length: 311
snps: rs2869020 rs34961497 rs12790505
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH79
geneSymbol: OR6X1
reactome: R-HSA-381753;
name: Olfactory receptor 6X1 (Olfactory receptor OR11-270)
length: 312
go: ENSG00000221931;
snps: rs12364099
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGP6
geneSymbol: OR5M8
reactome: R-HSA-381753;
name: Olfactory receptor 5M8 (Olfactory receptor OR11-194)
length: 311
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: A6NFC9
geneSymbol: OR2W5
reactome: R-HSA-381753;
name: Putative olfactory receptor 2W5
length: 320
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGD3
geneSymbol: OR4K5
reactome: R-HSA-381753;
name: Olfactory receptor 4K5 (Olfactory receptor OR14-16)
length: 323
go: ENSG00000176281;
snps: rs17242341
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q15622
geneSymbol: OR7A5
reactome: R-HSA-381753;
name: Olfactory receptor 7A5 (Olfactory receptor OR19-17) (Olfactory receptor TPCR92)
length: 319
go: ENSG00000188269;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH41
geneSymbol: OR4K15
reactome: R-HSA-381753;
name: Olfactory receptor 4K15 (Olfactory receptor OR14-20)
length: 348
snps: rs4060024 rs3861512 rs3861513 rs10135246 rs2153466 rs10135467
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NG75
geneSymbol: OR5T1
reactome: R-HSA-381753;
name: Olfactory receptor 5T1 (Olfactory receptor OR11-179)
length: 326
snps: rs7126079 rs12360890
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; adrenergic receptor activity [GO:0004935]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; olfactory receptor activity [GO:0004984]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; behavioral response to cocaine [GO:0048148]; regulation of dopamine secretion [GO:0014059]; response to drug [GO:0042493]; synaptic transmission, dopaminergic [GO:0001963]


uniprotID: Q8IXE1
geneSymbol: OR4N5
reactome: R-HSA-381753;
name: Olfactory receptor 4N5 (Olfactory receptor OR14-33)
length: 308
snps: rs10131326 rs10140908 rs10134472 rs10141025
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P58173
geneSymbol: OR2B6
reactome: R-HSA-381753;
length: 313
go: ENSG00000124657;
snps: rs7767176 rs9380030
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 2B6 (Hs6M1-32) (Olfactory receptor 2B1) (Olfactory receptor 2B5) (Olfactory receptor 5-40) (OR5-40) (Olfactory receptor 6-31) (OR6-31) (Olfactory receptor OR6-4)

sequence:


uniprotID: Q5JQS5
geneSymbol: OR2B11
reactome: R-HSA-381753;
name: Olfactory receptor 2B11
length: 317
go: ENSG00000177535;
snps: rs11583410 rs6695302 rs4925663 rs12065526 rs12070953
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: O95371
geneSymbol: OR2C1
reactome: R-HSA-381753;
length: 312
snps: rs1218762 rs1218763 rs11648783
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 2C1 (OLFmf3) (Olfactory receptor 2C2) (Olfactory receptor OR16-1) (Olfactory receptor OR16-2)

sequence:

opentargets:
cell cortex [GO:0005938]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; odorant binding [GO:0005549]; olfactory receptor activity [GO:0004984]


uniprotID: Q13607
geneSymbol: OR2F1
reactome: R-HSA-381753;
length: 317
snps: rs2072164 rs2072165
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 2F1 (Olfactory receptor 2F3) (Olfactory receptor 2F4) (Olfactory receptor 2F5) (Olfactory receptor-like protein OLF3)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; signal transduction [GO:0007165]


uniprotID: Q8NGE7
geneSymbol: OR9K2
reactome: R-HSA-381753;
name: Olfactory receptor 9K2 (Olfactory receptor OR12-2)
length: 335
snps: rs12303066 rs7305779 rs7306491
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: O95007
geneSymbol: OR6B1
reactome: R-HSA-381753;
name: Olfactory receptor 6B1 (Olfactory receptor 7-3) (OR7-3) (Olfactory receptor OR7-9)
length: 311
snps: rs7787378
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q6IFH4
geneSymbol: OR6B2
reactome: R-HSA-381753;
name: Olfactory receptor 6B2 (Olfactory receptor OR2-1)
length: 312
snps: rs10187574 rs60841887
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGW1
geneSymbol: OR6B3
reactome: R-HSA-381753;
name: Olfactory receptor 6B3 (Olfactory receptor OR2-2)
length: 331
go: ENSG00000178586;
snps: rs12465491
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9GZK4
geneSymbol: OR2H1
reactome: R-HSA-381753;
length: 316
go: ENSG00000204688;
snps: rs61732185 rs17184086
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Olfactory receptor 2H1 (Hs6M1-16) (OLFR42A-9004.14/9026.2) (Olfactory receptor 2H6) (Olfactory receptor 2H8) (Olfactory receptor 6-2) (OR6-2) (Olfactory receptor OR6-32)

sequence:


uniprotID: O95918
geneSymbol: OR2H2
reactome: R-HSA-381753;
name: Olfactory receptor 2H2 (Hs6M1-12) (Olfactory receptor 2H3) (Olfactory receptor-like protein FAT11)
length: 312
go: ENSG00000204657;
snps: rs3129034 rs3129034 rs11966382 rs1233387 rs141430371
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; olfactory receptor activity [GO:0004984]; defense response [GO:0006952]; mating [GO:0007618]


uniprotID: Q96RC9
geneSymbol: OR8B4
reactome: R-HSA-381753;
name: Olfactory receptor 8B4 (Olfactory receptor OR11-315)
length: 309
snps: rs10750270 rs4057750 rs7116575 rs4057749
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: O76001
geneSymbol: OR2J3
reactome: R-HSA-381753;
name: Olfactory receptor 2J3 (Hs6M1-3) (Olfactory receptor OR6-16) (OR6-6) (Olfactory receptor 6-6)
length: 311
snps: rs28757581 rs3749977 rs3130764 rs3130765
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH83
geneSymbol: OR4A5
reactome: R-HSA-381753;
name: Olfactory receptor 4A5 (Olfactory receptor OR11-111)
length: 315
go: ENSG00000221840;
snps: rs10902343 rs56302591 rs35083184
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q15617
geneSymbol: OR8G1
reactome: R-HSA-381753;
name: Olfactory receptor 8G1 (Olfactory receptor OR11-281) (Olfactory receptor TPCR25)
length: 311
snps: rs4482039
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NG78
geneSymbol: OR8G5
reactome: R-HSA-381753;
name: Olfactory receptor 8G5 (Olfactory receptor 8G6) (Olfactory receptor OR11-298)
length: 346
go: ENSG00000255298;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGY5
geneSymbol: OR6N1
reactome: R-HSA-381753;
name: Olfactory receptor 6N1
length: 312
go: ENSG00000197403;
snps: rs1864346 rs857827 rs857826 rs857825 rs857824
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9UBD5
geneSymbol: ORC3
reactome: R-HSA-113507;R-HSA-176187;R-HSA-68616;R-HSA-68689;R-HSA-68827;R-HSA-68867;R-HSA-68949;R-HSA-68962;
pdb: 5UJ8;5UJM;
name: Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo)
length: 711
go: ENSG00000135336;
snps: rs2307365 rs2307371 rs2307389 rs2307374 rs2307381 rs2307372 rs2307370 rs28381545
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
DNA replication preinitiation complex [GO:0031261]; nuclear body [GO:0016604]; nuclear chromosome, telomeric region [GO:0000784]; nuclear origin of replication recognition complex [GO:0005664]; nuclear pre-replicative complex [GO:0005656]; nucleoplasm [GO:0005654]; origin recognition complex [GO:0000808]; DNA replication origin binding [GO:0003688]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; neural precursor cell proliferation [GO:0061351]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UBD5-1; Sequence=Displayed; Name=2; IsoId=Q9UBD5-2; Sequence=VSP_017129; Note=No experimental confirmation available.; Name=3; IsoId=Q9UBD5-3; Sequence=VSP_044893; Note=No experimental confirmation available.; 


uniprotID: O43612
geneSymbol: HCRT
reactome: R-HSA-389397;R-HSA-416476;
pdb: 1CQ0;1R02;1UVQ;1WSO;
length: 131
go: ENSG00000161610;
drug: DB03088;
snps: rs104894574
name:
Orexin (Hypocretin) (Hcrt) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)]

sequence:
MNLPSTKVSWAAVTLLLLLLLLPPALLSSGAAAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRSGPPGLQGRLQRLLQASGNHAAGILTMGRRAGAEPAPRPCLGRRCSAPAAASVAPGGQSGI

opentargets:
cell junction [GO:0030054]; extracellular region [GO:0005576]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; rough endoplasmic reticulum [GO:0005791]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]; neuropeptide hormone activity [GO:0005184]; type 1 hypocretin receptor binding [GO:0031771]; type 2 hypocretin receptor binding [GO:0031772]; chemical synaptic transmission [GO:0007268]; eating behavior [GO:0042755]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of DNA replication [GO:0008156]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of transmission of nerve impulse [GO:0051970]; neuropeptide signaling pathway [GO:0007218]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of transmission of nerve impulse [GO:0051971]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; regulation of neurotransmitter secretion [GO:0046928]; temperature homeostasis [GO:0001659]

location:
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250}.


uniprotID: Q13416
geneSymbol: ORC2
reactome: R-HSA-113507;R-HSA-176187;R-HSA-68616;R-HSA-68689;R-HSA-68827;R-HSA-68867;R-HSA-68949;R-HSA-68962;
pdb: 5C8H;5UJ8;5UJM;
name: Origin recognition complex subunit 2
length: 577
go: ENSG00000115942;
snps: rs2307361 rs16835624
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
centrosome [GO:0005813]; condensed chromosome inner kinetochore [GO:0000939]; heterochromatin [GO:0000792]; membrane [GO:0016020]; nuclear chromosome, telomeric region [GO:0000784]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; DNA replication origin binding [GO:0003688]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of transcription by RNA polymerase II [GO:0000122]


uniprotID: O43913
geneSymbol: ORC5
reactome: R-HSA-113507;R-HSA-176187;R-HSA-68616;R-HSA-68689;R-HSA-68827;R-HSA-68867;R-HSA-68949;R-HSA-68962;
pdb: 5UJ7;5UJM;
name: Origin recognition complex subunit 5
length: 435
go: ENSG00000164815;
snps: rs1056677 rs2307413 rs2307402
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
cytosol [GO:0005829]; nuclear chromosome, telomeric region [GO:0000784]; nuclear origin of replication recognition complex [GO:0005664]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; origin recognition complex [GO:0000808]; ATP binding [GO:0005524]; DNA replication origin binding [GO:0003688]; nucleotide binding [GO:0000166]; DNA replication [GO:0006260]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43913-1; Sequence=Displayed; Name=2; Synonyms=ORC5T; IsoId=O43913-2; Sequence=VSP_042037; Note=Does not interact with ORC2.; 


uniprotID: Q96LW4
geneSymbol: PRIMPOL
pdb: 5L2X;5N85;5N8A;
length: 560
go: ENSG00000164306;
snps: rs200857997 rs2463447 rs14969
name:
DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.-) (Coiled-coil domain-containing protein 111)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA primase activity [GO:0003896]; DNA-directed DNA polymerase activity [GO:0003887]; manganese ion binding [GO:0030145]; mitochondrial DNA replication [GO:0006264]; replication fork processing [GO:0031297]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96LW4-1; Sequence=Displayed; Name=2; IsoId=Q96LW4-2; Sequence=VSP_053600; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Mitochondrion matrix. Note=Present in the nucleus, but a larger fraction is localized inside mitochondria. Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles.


uniprotID: Q9GZK7
geneSymbol: OR11A1
reactome: R-HSA-381753;
name: Olfactory receptor 11A1 (Hs6M1-18) (Olfactory receptor 11A2) (Olfactory receptor OR6-30)
length: 315
go: ENSG00000204694;
snps: rs16894898 rs9257857
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGE0
geneSymbol: OR10AD1
reactome: R-HSA-381753;
name: Olfactory receptor 10AD1 (Olfactory receptor OR12-1)
length: 317
snps: rs17122812 rs17224674 rs11830378 rs11168459
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGK1
geneSymbol: OR51G1
reactome: R-HSA-381753;
name: Olfactory receptor 51G1 (Olfactory receptor 51G3) (Olfactory receptor OR11-29)
length: 321
snps: rs10836954 rs34742470 rs1378739 rs12796015 rs57920748
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGY7
geneSymbol: OR10J6P
reactome: R-HSA-381753;
name: Putative olfactory receptor 10J6
length: 276
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
dendrite [GO:0030425]; integral component of plasma membrane [GO:0005887]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled serotonin receptor activity [GO:0004993]; neurotransmitter receptor activity [GO:0030594]; olfactory receptor activity [GO:0004984]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]


uniprotID: O15504
geneSymbol: NUPL2
name: Nucleoporin-like protein 2 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1)
length: 423
go: ENSG00000136243;
snps: rs13243961 rs34902971
sequence:

opentargets:
cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; nuclear export signal receptor activity [GO:0005049]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; protein export from nucleus [GO:0006611]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O15504-1; Sequence=Displayed; Name=2; IsoId=O15504-2; Sequence=VSP_016481, VSP_016482; Name=3; IsoId=O15504-3; Sequence=VSP_016480; 

location:
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:12228227, ECO:0000269|PubMed:16000379}. Nucleus membrane {ECO:0000269|PubMed:12228227, ECO:0000269|PubMed:16000379}; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12228227}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:10358091}.


uniprotID: A6NM76
geneSymbol: OR6C76
reactome: R-HSA-381753;
name: Olfactory receptor 6C76
length: 312
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9H4D5
geneSymbol: NXF3
name: Nuclear RNA export factor 3 (TAP-like protein 3) (TAPL-3)
length: 531
go: ENSG00000147206;
snps: rs2301387
location: SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H4D5-1; Sequence=Displayed; Name=2; IsoId=Q9H4D5-2; Sequence=VSP_057068, VSP_057069, VSP_057070; Note=No experimental confirmation available.; 


uniprotID: Q9H2C5
geneSymbol: OR52A5
reactome: R-HSA-381753;
name: Olfactory receptor 52A5 (Odorant receptor HOR3'beta5) (Olfactory receptor OR11-33)
length: 316
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q96CM4
geneSymbol: NXNL1
name: Nucleoredoxin-like protein 1 (Thioredoxin-like protein 6)
length: 212
go: ENSG00000171773;
location: SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250}.
sequence:

opentargets:
nuclear outer membrane [GO:0005640]; cell redox homeostasis [GO:0045454]; photoreceptor cell maintenance [GO:0045494]


uniprotID: Q9H346
geneSymbol: OR52D1
reactome: R-HSA-381753;
name: Olfactory receptor 52D1 (Odorant receptor HOR5'beta14) (Olfactory receptor OR11-43)
length: 318
snps: rs7935144 rs7924754 rs7950082 rs7101919 rs11037758
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGJ3
geneSymbol: OR52E1
reactome: R-HSA-381753;
name: Olfactory receptor 52E1
length: 308
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH53
geneSymbol: OR52N1
reactome: R-HSA-381753;
name: Olfactory receptor 52N1 (Olfactory receptor OR11-61)
length: 320
go: ENSG00000181001;
snps: rs12365487 rs10742787 rs10769224 rs7948009 rs7934670
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NH57
geneSymbol: OR52P1P
reactome: R-HSA-381753;
name: Putative olfactory receptor 52P1
length: 321
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P29728
geneSymbol: OAS2
reactome: R-HSA-877300;R-HSA-909733;
length: 719
go: ENSG00000111335;
name:
2'-5'-oligoadenylate synthase 2 ((2-5')oligo(A) synthase 2) (2-5A synthase 2) (EC 2.7.7.84) (p69 OAS / p71 OAS) (p69OAS / p71OAS)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; 2'-5'-oligoadenylate synthetase activity [GO:0001730]; ATP binding [GO:0005524]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; defense response to virus [GO:0051607]; interferon-gamma-mediated signaling pathway [GO:0060333]; nucleobase-containing compound metabolic process [GO:0006139]; regulation of lactation [GO:1903487]; regulation of ribonuclease activity [GO:0060700]; response to bacterium [GO:0009617]; response to virus [GO:0009615]; RNA catabolic process [GO:0006401]; type I interferon signaling pathway [GO:0060337]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=p71 {ECO:0000303|PubMed:1577824}; Synonyms=71 kDa {ECO:0000303|PubMed:1577824}; IsoId=P29728-1; Sequence=Displayed; Name=p69 {ECO:0000303|PubMed:1577824, ECO:0000303|PubMed:2211721}; Synonyms=69 kDa {ECO:0000303|PubMed:1577824, ECO:0000303|PubMed:2211721}; IsoId=P29728-2; Sequence=VSP_003741, VSP_003742; Name=3; IsoId=P29728-3; Sequence=VSP_043354, VSP_043355; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19923450}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19923450}.


uniprotID: Q8NAV1
geneSymbol: PRPF38A
reactome: R-HSA-72163;
pdb: 4RZ9;4RZA;5F5S;5O9Z;
name: Pre-mRNA-splicing factor 38A
length: 312
go: ENSG00000134748;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}.
sequence:

opentargets:
nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; precatalytic spliceosome [GO:0071011]; U2-type precatalytic spliceosome [GO:0071005]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NAV1-1; Sequence=Displayed; Name=2; IsoId=Q8NAV1-2; Sequence=VSP_025424; 


uniprotID: Q15743
geneSymbol: GPR68
reactome: R-HSA-373076;R-HSA-416476;
length: 365
go: ENSG00000119714;
snps: rs2230339 rs1057517672
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Ovarian cancer G-protein coupled receptor 1 (OGR-1) (G-protein coupled receptor 68) (GPR12A) (Sphingosylphosphorylcholine receptor)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; cellular response to pH [GO:0071467]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of monocyte differentiation [GO:0045656]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of osteoclast development [GO:2001206]


uniprotID: Q96E52
geneSymbol: OMA1
reactome: R-HSA-169911;
length: 524
go: ENSG00000162600;
snps: rs34466938 rs75220198 rs17117720 rs17117699 rs139938730 rs17117678 rs77980955
name:
Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog)

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; cristae formation [GO:0042407]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose metabolic process [GO:0006006]; lipid metabolic process [GO:0006629]; mitochondrial protein processing [GO:0034982]; negative regulation of mitochondrial fusion [GO:0010637]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein quality control for misfolded or incompletely synthesized proteins [GO:0006515]; regulation of apoptotic process [GO:0042981]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96E52-1; Sequence=Displayed; Name=2; IsoId=Q96E52-2; Sequence=VSP_027958; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:20038677}; Multi-pass membrane protein {ECO:0000305|PubMed:20038677}.


uniprotID: Q5VT98
geneSymbol: PRAMEF20
name: PRAME family member 20
length: 475
go: ENSG00000204478;
sequence:


uniprotID: Q9UI14
geneSymbol: RABAC1
name: Prenylated Rab acceptor protein 1 (PRA1 family protein 1)
length: 185
go: ENSG00000105404;
sequence:
MAAQKDQQKDAEAEGLSGTTLLPKLIPSGAGREWLERRRATIRPWSTFVDQQRFSRPRNLGELCQRLVRNVEYYQSNYVFVFLGLILYCVVTSPMLLVALAVFFGACYILYLRTLESKLVLFGREVSPAHQYALAGGISFPFFWLAGAGSAVFWVLGATLVVIGSHAAFHQIEAVDGEELQMEPV

opentargets:
cell junction [GO:0030054]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; identical protein binding [GO:0042802]; proline-rich region binding [GO:0070064]; protein C-terminus binding [GO:0008022]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35394}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O35394}. Golgi apparatus {ECO:0000250|UniProtKB:O35394}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:O35394}. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles. {ECO:0000250|UniProtKB:O35394}.


uniprotID: Q9NTK5
geneSymbol: OLA1
reactome: R-HSA-114608;
pdb: 2OHF;
name: Obg-like ATPase 1 (DNA damage-regulated overexpressed in cancer 45) (DOC45) (GTP-binding protein 9)
length: 396
go: ENSG00000138430;
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleolus [GO:0005730]; platelet alpha granule lumen [GO:0031093]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; cadherin binding [GO:0045296]; GTP binding [GO:0005525]; metal ion binding [GO:0046872]; ribosomal large subunit binding [GO:0043023]; ribosome binding [GO:0043022]; ATP metabolic process [GO:0046034]; platelet degranulation [GO:0002576]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NTK5-1; Sequence=Displayed; Name=2; IsoId=Q9NTK5-2; Sequence=VSP_002049; Name=3; IsoId=Q9NTK5-3; Sequence=VSP_002050, VSP_002051; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03167, ECO:0000269|PubMed:20053727}. Note=Predominantly cytoplasmic, shuttles between the nucleus and the cytoplasm. {ECO:0000255|HAMAP-Rule:MF_03167}.


uniprotID: Q96PE5
geneSymbol: OPALIN
name: Opalin (Oligodendrocytic myelin paranodal and inner loop protein) (Transmembrane protein 10)
length: 141
go: ENSG00000197430;
sequence:
MSFSLNFTLPANTTSSPVTGGKETDCGPSLGLAAGIPLLVATALLVALLFTLIHRRRSSIEAMEESDRPCEISEIDDNPKISENPRRSPTHEKNTMGAQEAHIYVKTVAGSEEPVHDRYRPTIEMERRRGLWWLVPRLSLE

opentargets:
cell-cell contact zone [GO:0044291]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96PE5-1; Sequence=Displayed; Name=2; IsoId=Q96PE5-2; Sequence=VSP_042943; Note=No experimental confirmation available.; Name=3; IsoId=Q96PE5-3; Sequence=VSP_046290; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=4; IsoId=Q96PE5-4; Sequence=VSP_054892; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. {ECO:0000250}.


uniprotID: Q96QH2
geneSymbol: PRAM1
name: PML-RARA-regulated adapter molecule 1 (PRAM) (PRAM-1)
length: 670
go: ENSG00000133246;
snps: rs4804305 rs4239541 rs4239540 rs58466313
sequence:

opentargets:
plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; lipid binding [GO:0008289]; protein kinase binding [GO:0019901]; integrin-mediated signaling pathway [GO:0007229]; regulation of neutrophil degranulation [GO:0043313]


uniprotID: Q9UKK9
geneSymbol: NUDT5
reactome: R-HSA-2393930;
pdb: 2DSB;2DSC;2DSD;3AC9;3ACA;3BM4;3L85;5NQR;5NWH;6GRU;
length: 219
go: ENSG00000165609;
snps: rs34863826
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:27257257}.
name:
ADP-sugar pyrophosphatase (EC 3.6.1.13) (8-oxo-dGDP phosphatase) (EC 3.6.1.58) (Nuclear ATP-synthesis protein NUDIX5) (EC 2.7.7.96) (Nucleoside diphosphate-linked moiety X motif 5) (Nudix motif 5) (hNUDT5) (YSA1H)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; nucleus [GO:0005634]; 8-oxo-dGDP phosphatase activity [GO:0044715]; ADP-ribose diphosphatase activity [GO:0047631]; ADP-sugar diphosphatase activity [GO:0019144]; magnesium ion binding [GO:0000287]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; snoRNA binding [GO:0030515]; ATP generation from poly-ADP-D-ribose [GO:1990966]; chromatin remodeling [GO:0006338]; D-ribose catabolic process [GO:0019303]; nucleobase-containing small molecule catabolic process [GO:0034656]; nucleotide metabolic process [GO:0009117]; ribonucleoside diphosphate catabolic process [GO:0009191]


uniprotID: Q96RD3
geneSymbol: OR52E6
reactome: R-HSA-381753;
name: Olfactory receptor 52E6 (Olfactory receptor OR11-58)
length: 313
snps: rs4362173 rs10769272 rs4495918 rs4592451 rs10838719 rs4357719 rs7943698 rs10742809
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8IWE2
geneSymbol: FAM114A1
name: Protein NOXP20 (Nervous system overexpressed protein 20) (Protein FAM114A1)
length: 563
go: ENSG00000197712;
opentargets: cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
snps: rs34137542 rs11096964 rs11555334 rs430296 rs2306923 rs17429619 rs36058104
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWE2-1; Sequence=Displayed; Name=2; IsoId=Q8IWE2-2; Sequence=VSP_056466; Note=No experimental confirmation available.; 


uniprotID: P04181
geneSymbol: OAT
reactome: R-HSA-70614;
pdb: 1GBN;1OAT;2BYJ;2BYL;2CAN;2OAT;5VWO;
length: 439
go: ENSG00000065154;
drug: DB02821;DB02054;DB00129;DB00114;
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23076989}.
name:
Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]

sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ornithine-oxo-acid transaminase activity [GO:0004587]; pyridoxal phosphate binding [GO:0030170]; arginine catabolic process to glutamate [GO:0019544]; arginine catabolic process to proline via ornithine [GO:0010121]; cellular amino acid biosynthetic process [GO:0008652]; L-proline biosynthetic process [GO:0055129]; protein hexamerization [GO:0034214]; visual perception [GO:0007601]

snps:
rs11553554 rs121965048 rs121965037 rs386833602 rs121965060 rs121965038 rs386833604 rs121965039 rs121965040 rs267606925 rs121965059 rs121965051 rs121965046 rs121965052 rs386833618 rs121965041 rs121965042 rs386833621 rs121965049 rs121965047 rs121965053 rs121965045 rs121965054 rs386833597 rs121965043 rs121965044 rs386833598 rs1800456 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P04181-1; Sequence=Displayed; Name=2; IsoId=P04181-2; Sequence=VSP_043085; 


uniprotID: P0C7T3
geneSymbol: OR56A5
reactome: R-HSA-381753;
name: Olfactory receptor 56A5
length: 313
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; adrenergic receptor activity [GO:0004935]; dopamine binding [GO:0035240]; dopamine neurotransmitter receptor activity, coupled via Gi/Go [GO:0001591]; olfactory receptor activity [GO:0004984]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; adenylate cyclase-inhibiting dopamine receptor signaling pathway [GO:0007195]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; behavioral response to cocaine [GO:0048148]; regulation of dopamine secretion [GO:0014059]; response to drug [GO:0042493]; synaptic transmission, dopaminergic [GO:0001963]


uniprotID: O95190
geneSymbol: OAZ2
reactome: R-HSA-350562;
name: Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2)
length: 189
go: ENSG00000180304;
drug: DB00129;
snps: rs3751534
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:
MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ornithine decarboxylase inhibitor activity [GO:0008073]; negative regulation of polyamine transmembrane transport [GO:1902268]; polyamine biosynthetic process [GO:0006596]; polyamine metabolic process [GO:0006595]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of protein catabolic process [GO:0045732]; regulation of cellular amino acid metabolic process [GO:0006521]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=A ribosomal frameshift occurs between the codons for Ser-32 and Asp-33. An autoregulatory mechanism enables modulation of frameshifting according to the cellular concentration of polyamines.; Name=1; IsoId=O95190-1; Sequence=Displayed; 


uniprotID: Q8N2U9
geneSymbol: PQLC1
name: PQ-loop repeat-containing protein 1
length: 271
go: ENSG00000122490;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; endosome [GO:0005768]; integral component of membrane [GO:0016021]; trans-Golgi network [GO:0005802]; phospholipid translocation [GO:0045332]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N2U9-1; Sequence=Displayed; Name=2; IsoId=Q8N2U9-2; Sequence=VSP_024145; Name=3; IsoId=Q8N2U9-3; Sequence=VSP_043275, VSP_043276; Note=No experimental confirmation available.; 


uniprotID: Q8WWZ8
geneSymbol: OIT3
name: Oncoprotein-induced transcript 3 protein (Liver-specific zona pellucida domain-containing protein)
length: 545
go: ENSG00000138315;
opentargets: nuclear envelope [GO:0005635]; calcium ion binding [GO:0005509]; urate homeostasis [GO:1903118]
snps: rs35089256
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WWZ8-1; Sequence=Displayed; Name=2; IsoId=Q8WWZ8-2; Sequence=VSP_027482, VSP_027483; 

location:
SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:12939600}. Note=Can be secreted into blood.


uniprotID: Q5SWX8
geneSymbol: ODR4
length: 454
go: ENSG00000157181;
opentargets: integral component of membrane [GO:0016021]; protein localization [GO:0008104]
snps: rs12084264
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
name:
Protein odr-4 homolog (hODR-4) (LAG1-interacting protein) (Transactivated by transforming growth factor beta protein 1)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5SWX8-1; Sequence=Displayed; Name=2; IsoId=Q5SWX8-2; Sequence=VSP_028098; Note=No experimental confirmation available.; Name=3; IsoId=Q5SWX8-3; Sequence=VSP_028099, VSP_028100; Name=4; IsoId=Q5SWX8-4; Sequence=VSP_044478; Note=No experimental confirmation available.; 


uniprotID: Q5VWM3
geneSymbol: PRAMEF18
name: PRAME family member 18
length: 479
go: ENSG00000279804;
sequence:


uniprotID: A3QJZ7
geneSymbol: PRAMEF27
name: PRAME family member 27
length: 478
sequence:


uniprotID: A0A0G2JMD5
geneSymbol: PRAMEF33
name: PRAME family member 33
length: 474
sequence:


uniprotID: P78395
geneSymbol: PRAME
length: 509
go: ENSG00000185686;
snps: rs1129172 rs41277507
name:
Melanoma antigen preferentially expressed in tumors (Opa-interacting protein 4) (OIP-4) (Preferentially expressed antigen of melanoma)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; retinoic acid receptor binding [GO:0042974]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell differentiation [GO:0045596]; negative regulation of retinoic acid receptor signaling pathway [GO:0048387]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell proliferation [GO:0008284]; regulation of growth [GO:0040008]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16620968}. Cell membrane {ECO:0000269|PubMed:16620968}.


uniprotID: Q9BXM0
geneSymbol: PRX
pdb: 4CMZ;
name: Periaxin
length: 1461
go: ENSG00000105227;
sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; axon ensheathment [GO:0008366]; regulation of RNA splicing [GO:0043484]

snps:
rs117336941 rs146789340 rs149715830 rs3814290 rs268671 rs268673 rs3745202 rs268674 rs751742049 rs533966999 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=L-periaxin; IsoId=Q9BXM0-1; Sequence=Displayed; Name=2; Synonyms=S-periaxin; IsoId=Q9BXM0-2; Sequence=VSP_004363, VSP_004364; Name=3; IsoId=Q9BXM0-3; Sequence=VSP_040352; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250|UniProtKB:O55103}; Peripheral membrane protein {ECO:0000250|UniProtKB:O55103}; Cytoplasmic side {ECO:0000250|UniProtKB:O55103}. Nucleus {ECO:0000269|PubMed:24633211}. Cytoplasm {ECO:0000269|PubMed:24633211}. Note=Detected in the Schwann cell nucleus prior to the onset of myelination. Detected in Schwann cells at periaxonal myelin membranes. Associated with the cell membrane during myelination. {ECO:0000250|UniProtKB:O55103}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000250|UniProtKB:O55103}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O55103}. Cell junction {ECO:0000250|UniProtKB:O55103}. Note=Colocalizes with ACTB at tricellular junctions between eye lens fiber cells. {ECO:0000250|UniProtKB:O55103}.


uniprotID: Q5JSZ5
geneSymbol: PRRC2B
name: Protein PRRC2B (HLA-B-associated transcript 2-like 1) (Proline-rich coiled-coil protein 2B)
length: 2229
go: ENSG00000130723;
opentargets: RNA binding [GO:0003723]
snps: rs34553878 rs10736851 rs10751478
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=5; IsoId=Q5JSZ5-1; Sequence=Displayed; Name=2; IsoId=Q5JSZ5-2; Sequence=VSP_022760; Name=3; IsoId=Q5JSZ5-3; Sequence=VSP_022760, VSP_022761; Name=4; IsoId=Q5JSZ5-4; Sequence=VSP_022760, VSP_022762; Name=1; IsoId=Q5JSZ5-5; Sequence=VSP_039905; 


uniprotID: Q9NQV5
geneSymbol: PRDM11
pdb: 3RAY;
name: PR domain-containing protein 11 (EC 2.1.1.-)
length: 511
go: ENSG00000019485;
snps: rs111724149 rs35090414
sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; chromatin DNA binding [GO:0031490]; core promoter binding [GO:0001047]; methyltransferase activity [GO:0008168]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; negative regulation of cell growth [GO:0030308]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of fibroblast apoptotic process [GO:2000271]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell cycle [GO:0051726]; regulation of MAPK cascade [GO:0043408]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NQV5-1; Sequence=Displayed; Name=2; IsoId=Q9NQV5-2; Sequence=VSP_039836; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25499759}. Cytoplasm {ECO:0000269|PubMed:25499759}.


uniprotID: P41145
geneSymbol: OPRK1
reactome: R-HSA-375276;R-HSA-418594;
pdb: 2A0D;2IQN;4DJH;6B73;
name: Kappa-type opioid receptor (K-OR-1) (KOR-1)
length: 380
go: ENSG00000082556;
snps: rs9282808
sequence:

opentargets:
axon terminus [GO:0043679]; cytosol [GO:0005829]; dendrite [GO:0030425]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic membrane [GO:0099055]; integral component of presynaptic membrane [GO:0099056]; integral component of synaptic vesicle membrane [GO:0030285]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; dynorphin receptor activity [GO:0038048]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; opioid receptor activity [GO:0004985]; receptor serine/threonine kinase binding [GO:0033612]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; behavioral response to cocaine [GO:0048148]; cellular response to glucose stimulus [GO:0071333]; cellular response to lipopolysaccharide [GO:0071222]; chemical synaptic transmission [GO:0007268]; conditioned place preference [GO:1990708]; defense response to virus [GO:0051607]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; locomotory behavior [GO:0007626]; maternal behavior [GO:0042711]; negative regulation of luteinizing hormone secretion [GO:0033685]; neuropeptide signaling pathway [GO:0007218]; opioid receptor signaling pathway [GO:0038003]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of dopamine secretion [GO:0033603]; positive regulation of eating behavior [GO:1904000]; positive regulation of locomotion [GO:0040017]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of potassium ion transmembrane transport [GO:1901381]; regulation of saliva secretion [GO:0046877]; regulation of sensory perception of pain [GO:0051930]; response to acrylamide [GO:1903937]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to insulin [GO:0032868]; response to morphine [GO:0043278]; response to radiation [GO:0009314]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; sensory perception of temperature stimulus [GO:0050951]

drug:
DB01571;DB01439;DB05443;DB06274;DB00321;DB05104;DB00921;DB00611;DB01535;DB00318;DB05155;DB00514;DB00647;DB01209;DB01565;DB01548;DB09272;DB01497;DB00813;DB01452;DB00327;DB01221;DB06738;DB00854;DB00836;DB00825;DB06800;DB06148;DB00370;DB00295;DB00844;DB01183;DB00704;DB00497;DB00652;DB00454;DB00396;DB09396;DB00899;DB00708;DB06204;DB00193;DB05046;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P41145-1; Sequence=Displayed; Name=2; IsoId=P41145-2; Sequence=VSP_055313; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}; Multi-pass membrane protein {ECO:0000269|PubMed:12004055, ECO:0000269|PubMed:22437504, ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.


uniprotID: Q8TEA1
geneSymbol: NSUN6
reactome: R-HSA-6782315;
pdb: 5WWQ;5WWR;5WWS;5WWT;
length: 469
go: ENSG00000241058;
name:
Putative methyltransferase NSUN6 (EC 2.1.1.-) (NOL1/NOP2/Sun and PUA domain-containing protein 1) (NOL1/NOP2/Sun domain family member 6)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; tRNA (cytosine-5-)-methyltransferase activity [GO:0016428]; tRNA binding [GO:0000049]; tRNA modification [GO:0006400]


uniprotID: Q9Y2I2
geneSymbol: NTNG1
reactome: R-HSA-163125;
pdb: 3ZYJ;
name: Netrin-G1 (Laminet-1)
length: 539
go: ENSG00000162631;
sequence:

opentargets:
anchored component of plasma membrane [GO:0046658]; anchored component of presynaptic active zone membrane [GO:0099029]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; plasma membrane [GO:0005886]; Schaffer collateral - CA1 synapse [GO:0098685]; cell adhesion molecule binding [GO:0050839]; cell-cell adhesion mediator activity [GO:0098632]; axonogenesis [GO:0007409]; modulation of chemical synaptic transmission [GO:0050804]; synaptic membrane adhesion [GO:0099560]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=3; Synonyms=1A; IsoId=Q9Y2I2-3; Sequence=Displayed; Note=Mostly expressed in adult brain.; Name=2; Synonyms=1F; IsoId=Q9Y2I2-2; Sequence=VSP_010429, VSP_010430; Name=1; Synonyms=1C; IsoId=Q9Y2I2-1; Sequence=VSP_012574, VSP_012579; Note=Hi expression in Expressed in brain and.; Name=4; Synonyms=1D; IsoId=Q9Y2I2-4; Sequence=VSP_012575; Note=Mostly expressed in kidney, also expressed in adult and fetal brain.; Name=5; Synonyms=1E; IsoId=Q9Y2I2-5; Sequence=VSP_012576, VSP_012577; Note=Some expression in fetal brain.; Name=6; Synonyms=1G; IsoId=Q9Y2I2-6; Sequence=VSP_012578, VSP_012580; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21946559}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21946559}; Extracellular side {ECO:0000269|PubMed:21946559}.


uniprotID: Q9UKG9
geneSymbol: CROT
reactome: R-HSA-389887;R-HSA-9033241;
name: Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)
length: 612
go: ENSG00000005469;
drug: DB02648;DB00583;
snps: rs3827653 rs7785206
location: SUBCELLULAR LOCATION: Peroxisome {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; carnitine O-octanoyltransferase activity [GO:0008458]; signaling receptor binding [GO:0005102]; carnitine metabolic process [GO:0009437]; coenzyme A metabolic process [GO:0015936]; fatty acid beta-oxidation [GO:0006635]; fatty acid beta-oxidation using acyl-CoA oxidase [GO:0033540]; fatty acid metabolic process [GO:0006631]; fatty acid transport [GO:0015908]; generation of precursor metabolites and energy [GO:0006091]; medium-chain fatty acid metabolic process [GO:0051791]; protein targeting to peroxisome [GO:0006625]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UKG9-1; Sequence=Displayed; Name=2; IsoId=Q9UKG9-2; Sequence=VSP_045213, VSP_045214; Name=3; IsoId=Q9UKG9-3; Sequence=VSP_046953; Note=No experimental confirmation available. Gene prediction based on cDNA data.; 


uniprotID: Q9ULJ1
geneSymbol: ODF2L
name: Protein BCAP (Basal body centriole-associated protein) (Outer dense fiber protein 2-like)
length: 636
go: ENSG00000122417;
snps: rs12032435 rs17854440
sequence:

opentargets:
centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cell projection organization [GO:0030030]; negative regulation of cilium assembly [GO:1902018]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=L-BCAP {ECO:0000303|PubMed:17485331}; IsoId=Q9ULJ1-1; Sequence=Displayed; Name=2; IsoId=Q9ULJ1-2; Sequence=VSP_029058, VSP_029060; Name=3; IsoId=Q9ULJ1-3; Sequence=VSP_029057, VSP_029059; Name=4; IsoId=Q9ULJ1-4; Sequence=VSP_029057, VSP_029060; Name=5; IsoId=Q9ULJ1-5; Sequence=VSP_040930, VSP_029057, VSP_029060; Name=6; IsoId=Q9ULJ1-6; Sequence=VSP_029057, VSP_029058, VSP_029060; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17485331}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:17485331}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28775150}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17485331}. Note=Localizes to centrioles in proliferative cells and basal bodies in ciliated cells (PubMed:17485331). Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed (PubMed:28775150). {ECO:0000269|PubMed:17485331, ECO:0000269|PubMed:28775150}.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28775150}. Note=Not present in the centrioles in cycling cells. Disappears during ciliogenesis. {ECO:0000269|PubMed:28775150}.; SUBCELLULAR LOCATION: Isoform 6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28775150}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28775150}. Note=Disappears during ciliogenesis but reappears, albeit at a lower levels once ciliogenesis has completed. {ECO:0000269|PubMed:28775150}.


uniprotID: Q5BJF6
geneSymbol: ODF2
reactome: R-HSA-2565942;R-HSA-380259;R-HSA-380270;R-HSA-380284;R-HSA-380320;R-HSA-5620912;R-HSA-8854518;
name: Outer dense fiber protein 2 (Cenexin) (Outer dense fiber of sperm tails protein 2)
length: 829
go: ENSG00000136811;
snps: rs16930426
sequence:

opentargets:
centriolar subdistal appendage [GO:0120103]; centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary transition fiber [GO:0097539]; cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; outer dense fiber [GO:0001520]; sperm flagellum [GO:0036126]; spindle pole [GO:0000922]; Rab GTPase binding [GO:0017137]; structural molecule activity [GO:0005198]; centriole-centriole cohesion [GO:0010457]; ciliary basal body-plasma membrane docking [GO:0097711]; cilium organization [GO:0044782]; G2/M transition of mitotic cell cycle [GO:0000086]; multicellular organism development [GO:0007275]; protein localization [GO:0008104]; regulation of cilium assembly [GO:1902017]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; spermatid development [GO:0007286]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=10;  Name=1; IsoId=Q5BJF6-1; Sequence=Displayed; Name=2; IsoId=Q5BJF6-2; Sequence=VSP_027665, VSP_027667; Note=No experimental confirmation available.; Name=3; Synonyms=Cenexin 1; IsoId=Q5BJF6-3; Sequence=VSP_027666, VSP_027667; Name=4; Synonyms=Cenexin 1 variant 1; IsoId=Q5BJF6-4; Sequence=VSP_027666; Name=5; Synonyms=Cenexin 1, ODF2/1; IsoId=Q5BJF6-5; Sequence=VSP_027667, VSP_027668, VSP_027669; Note=Major.; Name=6; Synonyms=Isoform 3, ODF2/2; IsoId=Q5BJF6-6; Sequence=VSP_027668, VSP_027669; Name=7; IsoId=Q5BJF6-7; Sequence=VSP_042071, VSP_027668, VSP_027669; Name=8; IsoId=Q5BJF6-8; Sequence=VSP_042070, VSP_027667, VSP_027668, VSP_027669; Name=9; IsoId=Q5BJF6-9; Sequence=VSP_027666, VSP_042072, VSP_027668, VSP_027669; Name=10; IsoId=Q5BJF6-10; Sequence=VSP_044946, VSP_027668, VSP_027669; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16966375}. Cell projection, cilium {ECO:0000250|UniProtKB:A3KGV1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23400999}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:A3KGV1}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:A3KGV1}. Note=Localized at the microtubule organizing centers in interphase and spindle poles in mitosis. Localized at the distal/subdistal appendages of mother centrioles. {ECO:0000250|UniProtKB:A3KGV1}.


uniprotID: Q5SWA1
geneSymbol: PPP1R15B
pdb: 4V0U;4V0V;4V0W;4V0X;
name: Protein phosphatase 1 regulatory subunit 15B
length: 713
snps: rs12094135 rs4492688 rs3014626 rs2089891 rs17855962
sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; protein phosphatase type 1 complex [GO:0000164]; protein phosphatase regulator activity [GO:0019888]; ER overload response [GO:0006983]; negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation [GO:1903912]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of protein phosphorylation [GO:0001933]; peptidyl-serine dephosphorylation [GO:0070262]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; response to endoplasmic reticulum stress [GO:0034976]; response to hydrogen peroxide [GO:0042542]


uniprotID: Q5VTL8
geneSymbol: PRPF38B
name: Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27)
length: 546
go: ENSG00000134186;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5VTL8-1; Sequence=Displayed; Name=2; IsoId=Q5VTL8-2; Sequence=VSP_025408, VSP_025409; 


uniprotID: O75400
geneSymbol: PRPF40A
reactome: R-HSA-72163;
pdb: 1UZC;1YWI;1YWJ;1ZR7;2CQN;2DYF;2KZG;2L5F;2L9V;2LKS;
length: 957
go: ENSG00000196504;
name:
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U1 snRNP [GO:0005685]; U2-type prespliceosome [GO:0071004]; RNA binding [GO:0003723]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; mRNA splicing, via spliceosome [GO:0000398]; regulation of cell shape [GO:0008360]; regulation of cytokinesis [GO:0032465]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O75400-1; Sequence=Displayed; Name=2; IsoId=O75400-2; Sequence=VSP_040781, VSP_008047; Name=3; IsoId=O75400-3; Sequence=VSP_008048; Name=5; IsoId=O75400-5; Sequence=VSP_040781, VSP_008047, VSP_040782, VSP_040783; Note=Probable target of nonsense-mediated mRNA decay. {ECO:0000244|PubMed:24129315}; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Nucleus matrix {ECO:0000269|PubMed:16391387}. Note=Colocalizes with AKAP8L in the nuclear matrix. {ECO:0000250}.


uniprotID: A3QJZ6
geneSymbol: PRAMEF22
name: PRAME family member 22
length: 481
sequence:


uniprotID: Q96KF2
geneSymbol: PRAC1
sequence: MLCAHFSDQGPAHLTTSKSAFLSNKKTSTLKHLLGETRSDGSACNSGISGGRGRKIP
length: 57
go: ENSG00000159182;
opentargets: nucleus [GO:0005634]
snps: rs34734055
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11340635}.
name:
Small nuclear protein PRAC1 (Prostate cancer susceptibility candidate protein 1) (Prostate, rectum and colon expressed gene protein)


uniprotID: P78380
geneSymbol: OLR1
reactome: R-HSA-202733;R-HSA-6798695;
pdb: 1YPO;1YPQ;1YPU;1YXJ;1YXK;3VLG;
length: 273
go: ENSG00000173391;
snps: rs11053646
name:
Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) (C-type lectin domain family 8 member A) (Lectin-like oxidized LDL receptor 1) (LOX-1) (Lectin-like oxLDL receptor 1) (hLOX-1) (Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1, soluble form]

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; carbohydrate binding [GO:0030246]; identical protein binding [GO:0042802]; blood circulation [GO:0008015]; cell adhesion [GO:0007155]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; neutrophil degranulation [GO:0043312]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P78380-1; Sequence=Displayed; Name=2; IsoId=P78380-2; Sequence=VSP_042555; Note=No experimental confirmation available.; Name=3; IsoId=P78380-3; Sequence=VSP_045277; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.


uniprotID: Q9H6K4
geneSymbol: OPA3
name: Optic atrophy 3 protein
length: 179
go: ENSG00000125741;
snps: rs80356524 rs80356525
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
sequence:
MVVGAFPMAKLLYLGIRQVSKPLANRIKEAARRSEFFKTYICLPPAQLYHWVEMRTKMRIMGFRGTVIKPLNEEAAAELGAELLGEATIFIVGGGCLVLEYWRHQAQQRHKEEEQRAAWNALRDEVGHLALALEALQAQVQAAPPQGALEELRTELQEVRAQLCNPGRSASHAVPASKK

opentargets:
mitochondrion [GO:0005739]; mitochondrion morphogenesis [GO:0070584]; neuromuscular process [GO:0050905]; regulation of growth [GO:0040008]; regulation of lipid metabolic process [GO:0019216]; response to stimulus [GO:0050896]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=The two isoforms share the first coding exon and than differ due to a duplicated alternative second coding exon.; Name=1; IsoId=Q9H6K4-1; Sequence=Displayed; Name=2; IsoId=Q9H6K4-2; Sequence=VSP_032681; 


uniprotID: O60422
geneSymbol: ONECUT3
reactome: R-HSA-210744;R-HSA-210747;
name: One cut domain family member 3 (One cut homeobox 3) (Transcription factor ONECUT-3) (OC-3)
length: 494
go: ENSG00000205922;
sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374}.


uniprotID: A6NGQ2
geneSymbol: OOEP
length: 149
go: ENSG00000203907;
opentargets: cytoplasm [GO:0005737]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]
snps: rs2280286 rs496530
name:
Oocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19)

sequence:
MVDDAGAAESQRGKQTPAHSLEQLRRLPLPPPQIRIRPWWFPVQELRDPLVFYLEAWLADELFGPDRAIIPEMEWTSQALLTVDIVDSGNLVEITVFGRPRVQNRVKSMLLCLAWFHREHRARAEKMKHLEKNLKAHASDPHSPQDPVA

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.


uniprotID: A8MZH6
geneSymbol: OOSP1
name: Putative oocyte-secreted protein 1 homolog
length: 123
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MKTILGFKGLFYLHSLIWTCAGDWSAIQVHCTQFWFFARIKPTIFYNLYVNPDEVFLGDGCHVTHVLPNVYYEFFYHPHDCGIVTQPLQEVLLLKTKIRYISRDSTVRSEMPLSCVVHKQKCQ


uniprotID: Q96NZ9
geneSymbol: PRAP1
length: 151
go: ENSG00000165828;
snps: rs34780987 rs4369319
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14583459}.
name:
Proline-rich acidic protein 1 (Epididymis tissue protein Li 178) (Uterine-specific proline-rich acidic protein)

sequence:
MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ

opentargets:
extracellular region [GO:0005576]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PRAP; IsoId=Q96NZ9-1; Sequence=Displayed; Name=2; IsoId=Q96NZ9-2; Sequence=VSP_027661, VSP_027662; Name=3; Synonyms=PRAPV1; IsoId=Q96NZ9-3; Sequence=VSP_027660; Name=4; Synonyms=PRAPV2; IsoId=Q96NZ9-4; Sequence=VSP_027661; 


uniprotID: A6NF83
geneSymbol: NUPR2
sequence: MEAPAERALPRLQALARPPPPISYEEELYDCLDYYYLRDFPACGAGRSKGRTRREQALRTNWPAPGGHERKVAQKLLNGQRKRRQRQLHPKMRTRLT
length: 97
go: ENSG00000185290;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25899918}.
name:
Nuclear protein 2 (Nuclear transcriptional regulator 1-like protein) (Nuclear transcriptional regulator protein 2)

opentargets:
nucleus [GO:0005634]; cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to starvation [GO:0009267]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]


uniprotID: Q6UX06
geneSymbol: OLFM4
reactome: R-HSA-6798695;
length: 510
go: ENSG00000102837;
snps: rs35790097
name:
Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD)

sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule [GO:0042581]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; cadherin binding [GO:0045296]; catalytic activity [GO:0003824]; protein homodimerization activity [GO:0042803]; cell adhesion [GO:0007155]; neutrophil degranulation [GO:0043312]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; protein homooligomerization [GO:0051260]

location:
SUBCELLULAR LOCATION: Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269|PubMed:15059901, ECO:0000269|PubMed:16566923, ECO:0000269|PubMed:20724538}.


uniprotID: Q5SWL7
geneSymbol: PRAMEF14
name: PRAME family member 14
length: 426
sequence:


uniprotID: Q68BL7
geneSymbol: OLFML2A
name: Olfactomedin-like protein 2A (Photomedin-1)
length: 652
go: ENSG00000185585;
snps: rs7874348 rs16927649
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular matrix binding [GO:0050840]; protein homodimerization activity [GO:0042803]; extracellular matrix organization [GO:0030198]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q68BL7-1; Sequence=Displayed; Name=2; IsoId=Q68BL7-2; Sequence=VSP_029566; Name=3; IsoId=Q68BL7-3; Sequence=VSP_029565, VSP_029567; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BHP7}. Note=Localizes to the podocyte major processes. Colocalized with the major process protein VIM throughout podocyte development. {ECO:0000269|PubMed:22913984}.


uniprotID: Q68BL8
geneSymbol: OLFML2B
name: Olfactomedin-like protein 2B (Photomedin-2)
length: 750
go: ENSG00000162745;
opentargets: extracellular region [GO:0005576]
snps: rs12130792 rs2499836
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q68BL8-1; Sequence=Displayed; Name=2; IsoId=Q68BL8-2; Sequence=VSP_029564; 


uniprotID: A6NGN4
geneSymbol: PRAMEF25
name: PRAME family member 25
length: 478
go: ENSG00000229571;ENSG00000280267;
sequence:


uniprotID: H0Y7S4
geneSymbol: PRAMEF26
name: Putative PRAME family member 26
length: 382
opentargets: cytoplasm [GO:0005737]
sequence:


uniprotID: Q6UWY5
geneSymbol: OLFML1
name: Olfactomedin-like protein 1
length: 402
go: ENSG00000183801;
opentargets: extracellular region [GO:0005576]
snps: rs12805648 rs12803046
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18708057}.
sequence:


uniprotID: P23515
geneSymbol: OMG
reactome: R-HSA-193634;
name: Oligodendrocyte-myelin glycoprotein
length: 440
go: ENSG00000126861;
snps: rs11080149 rs16972169
location: SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
sequence:

opentargets:
anchored component of membrane [GO:0031225]; plasma membrane [GO:0005886]; cell adhesion [GO:0007155]; negative regulation of axonogenesis [GO:0050771]; neuron projection regeneration [GO:0031102]


uniprotID: O95948
geneSymbol: ONECUT2
length: 504
go: ENSG00000119547;
location: SUBCELLULAR LOCATION: Nucleus.
name:
One cut domain family member 2 (Hepatocyte nuclear factor 6-beta) (HNF-6-beta) (One cut homeobox 2) (Transcription factor ONECUT-2) (OC-2)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cell fate commitment [GO:0045165]; cilium assembly [GO:0060271]; endocrine pancreas development [GO:0031018]; epithelial cell development [GO:0002064]; liver development [GO:0001889]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; peripheral nervous system neuron development [GO:0048935]; positive regulation of cell migration [GO:0030335]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell-matrix adhesion [GO:0001952]


uniprotID: P47874
geneSymbol: OMP
name: Olfactory marker protein (Olfactory neuronal-specific protein)
length: 163
go: ENSG00000254550;
snps: rs2233546 rs2233548
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:
MAEDRPQQPQLDMPLVLDQGLTRQMRLRVESLKQRGEKRQDGEKLLQPAESVYRLNFTQQQRLQFERWNVVLDKPGKVTITGTSQNWTPDLTNLMTRQLLDPTAIFWRKEDSDAIDWNEADALEFGERLSDLAKIRKVMYFLVTFGEGVEPANLKASVVFNQL

opentargets:
axon [GO:0030424]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; chemical synaptic transmission [GO:0007268]; neurogenesis [GO:0022008]; sensory perception of smell [GO:0007608]; signal transduction [GO:0007165]


uniprotID: Q5VXH5
geneSymbol: PRAMEF7
name: PRAME family member 7
length: 474
go: ENSG00000204510;
sequence:


uniprotID: A0A2R8YFM6
geneSymbol: OOSP3
name: Oocyte-secreted protein 3
length: 193
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MKDFVRLQSSFLLCTILTLSEQESVSVGCTSSMFWVVAEPTLLGQDHILHSDEASLGTGCPVTNVTAKGYEFNYPATQCGIQKEVFSYVTVFYSALHCNIMHKGVTGKIPLMCIVYGSSLDTTSSTIHNNLTEFQNDPPATNSYSPWNLTNASLFGLTRIPYFQNSSVEASHQSLLLNMSHPLVHESANVAIF


uniprotID: Q9H1Y3
geneSymbol: OPN3
reactome: R-HSA-418594;R-HSA-419771;
name: Opsin-3 (Encephalopsin) (Panopsin)
length: 402
go: ENSG00000054277;
snps: rs12072790 rs2273712
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; photoreceptor outer segment [GO:0001750]; G protein-coupled photoreceptor activity [GO:0008020]; G protein-coupled receptor activity [GO:0004930]; photoreceptor activity [GO:0009881]; cellular response to light stimulus [GO:0071482]; detection of light stimulus [GO:0009583]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; protein-chromophore linkage [GO:0018298]; regulation of circadian rhythm [GO:0042752]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=1-4b-5-6; IsoId=Q9H1Y3-1; Sequence=Displayed; Name=2; Synonyms=1-2-5-6; IsoId=Q9H1Y3-2; Sequence=VSP_010209; 


uniprotID: P35372
geneSymbol: OPRM1
reactome: R-HSA-111885;R-HSA-202040;R-HSA-375276;R-HSA-418594;R-HSA-6785807;
name: Mu-type opioid receptor (M-OR-1) (MOR-1) (Mu opiate receptor) (Mu opioid receptor) (MOP) (hMOP)
length: 400
go: ENSG00000112038;
snps: rs1799972 rs1799971 rs9282817 rs9282819 rs17174794 rs17174801 rs1799974 rs17174822 rs17174829
sequence:

opentargets:
axon [GO:0030424]; cell [GO:0005623]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; dendrite membrane [GO:0032590]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic membrane [GO:0099055]; integral component of presynaptic membrane [GO:0099056]; membrane raft [GO:0045121]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; spine apparatus [GO:0097444]; beta-endorphin receptor activity [GO:0004979]; filamin binding [GO:0031005]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; morphine receptor activity [GO:0038047]; neuropeptide binding [GO:0042923]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; voltage-gated calcium channel activity [GO:0005245]; acute inflammatory response to antigenic stimulus [GO:0002438]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-inhibiting opioid receptor signaling pathway [GO:0031635]; behavioral response to ethanol [GO:0048149]; cytokine-mediated signaling pathway [GO:0019221]; eating behavior [GO:0042755]; estrous cycle [GO:0044849]; excitatory postsynaptic potential [GO:0060079]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; locomotory behavior [GO:0007626]; negative regulation of adenylate cyclase activity [GO:0007194]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cytosolic calcium ion concentration [GO:0051481]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of Wnt protein secretion [GO:0061358]; neuropeptide signaling pathway [GO:0007218]; opioid receptor signaling pathway [GO:0038003]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of appetite [GO:0032100]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of neurogenesis [GO:0050769]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; regulation of cellular response to stress [GO:0080135]; regulation of NMDA receptor activity [GO:2000310]; regulation of sensory perception of pain [GO:0051930]; response to cocaine [GO:0042220]; response to food [GO:0032094]; response to growth factor [GO:0070848]; response to lipopolysaccharide [GO:0032496]; response to radiation [GO:0009314]; sensory perception [GO:0007600]; sensory perception of pain [GO:0019233]; wound healing [GO:0042060]

drug:
DB01571;DB01439;DB00802;DB06274;DB00321;DB00913;DB00921;DB00611;DB01535;DB00318;DB00514;DB00647;DB01209;DB01565;DB01444;DB01081;DB01548;DB09272;DB05492;DB01466;DB01497;DB00813;DB01452;DB00956;DB00327;DB01221;DB06738;DB00504;DB01227;DB00854;DB05509;DB00836;DB00333;DB01433;DB06800;DB00295;DB00844;DB09049;DB01183;DB00704;DB00904;DB00497;DB01192;DB00652;DB00454;DB09396;DB00899;DB00708;DB06204;DB00193;DB05046;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=18;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=P35372-1; Sequence=Displayed; Name=2; Synonyms=MOR1A, MOR-1A; IsoId=P35372-2; Sequence=VSP_001896; Name=3; Synonyms=MOR-1R, MOR-1X; IsoId=P35372-3; Sequence=VSP_037695; Name=4; Synonyms=MOR-1B3; IsoId=P35372-4; Sequence=VSP_037696; Name=5; Synonyms=MOR-1C, MOR-1O; IsoId=P35372-5; Sequence=VSP_037697; Name=6; Synonyms=MOR-1V, MOR-1Y, MOR-1Y2, MOR-1Y3; IsoId=P35372-6; Sequence=VSP_037698; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=7; Synonyms=MOR-1B1; IsoId=P35372-7; Sequence=VSP_037699; Name=8; Synonyms=MOR-1B2; IsoId=P35372-8; Sequence=VSP_037700; Name=9; Synonyms=MOR-1B5; IsoId=P35372-9; Sequence=VSP_037701; Name=10; Synonyms=MOR-1i; IsoId=P35372-10; Sequence=VSP_037693; Name=11; Synonyms=MOR-1B4; IsoId=P35372-11; Sequence=VSP_037694; Name=12; Synonyms=MOR-1G1, MOR-1K; IsoId=P35372-12; Sequence=VSP_042327; Name=13; Synonyms=MOR-1G2; IsoId=P35372-13; Sequence=VSP_042328; Name=14; Synonyms=Mu3; IsoId=P35372-14; Sequence=VSP_042327, VSP_042331; Name=15; Synonyms=MOR-1W; IsoId=P35372-15; Sequence=VSP_042327, VSP_001896; Name=16; Synonyms=SV1; IsoId=P35372-16; Sequence=VSP_042330; Name=17; Synonyms=SV2; IsoId=P35372-17; Sequence=VSP_042329; Name=18; Synonyms=hMOR-1Z; IsoId=P35372-18; Sequence=VSP_047577, VSP_047578; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10529478, ECO:0000269|PubMed:12589820, ECO:0000269|PubMed:16580639, ECO:0000269|PubMed:7891175, ECO:0000269|PubMed:7905839, ECO:0000269|PubMed:7957926, ECO:0000269|PubMed:9689128}; Multi-pass membrane protein {ECO:0000269|PubMed:16580639}. Cell projection, axon {ECO:0000250|UniProtKB:P97266}. Perikaryon {ECO:0000250|UniProtKB:P97266}. Cell projection, dendrite {ECO:0000250|UniProtKB:P97266}. Endosome {ECO:0000250|UniProtKB:P97266}. Note=Is rapidly internalized after agonist binding. {ECO:0000250|UniProtKB:P97266}.; SUBCELLULAR LOCATION: Isoform 12: Cytoplasm {ECO:0000269|PubMed:20525224}.


uniprotID: Q96MT3
geneSymbol: PRICKLE1
reactome: R-HSA-4608870;
name: Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1)
length: 831
go: ENSG00000139174;
sequence:

opentargets:
cytosol [GO:0005829]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; aorta development [GO:0035904]; coronary vasculature development [GO:0060976]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle cell myoblast differentiation [GO:2000691]; negative regulation of transcription, DNA-templated [GO:0045892]; neural tube closure [GO:0001843]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]

snps:
rs141795695 rs796052934 rs113994140 rs371720624 rs79087668 rs281865563 rs559947948 rs281865564 rs768954477 rs138452760 rs3827522 

location:
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:14645515}. Cytoplasm, cytosol {ECO:0000269|PubMed:14645515}. Note=A smaller amount is detected in the cytosol.


uniprotID: Q8NH06
geneSymbol: OR1P1
reactome: R-HSA-381753;
name: Olfactory receptor 1P1 (Olfactory receptor 17-208) (OR17-208) (Olfactory receptor OR17-9)
length: 330
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q2TBC4
geneSymbol: PRICKLE4
name: Prickle-like protein 4 (Overexpressed breast tumor protein)
length: 344
go: ENSG00000124593;
opentargets: nucleus [GO:0005634]; zinc ion binding [GO:0008270]
snps: rs28403585
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q2TBC4-1; Sequence=Displayed; Name=2; IsoId=Q2TBC4-2; Sequence=VSP_017857; Name=3; IsoId=Q2TBC4-3; Sequence=VSP_039377; 


uniprotID: P34982
geneSymbol: OR1D2
reactome: R-HSA-381753;
length: 312
go: ENSG00000184166;
snps: rs769423 rs9916628 rs55803944 rs4300683
name:
Olfactory receptor 1D2 (Olfactory receptor 17-4) (OR17-4) (Olfactory receptor OR17-6) (Olfactory receptor-like protein HGMP07E)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; identical protein binding [GO:0042802]; olfactory receptor activity [GO:0004984]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of smell [GO:0007608]; single fertilization [GO:0007338]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16820410}; Multi-pass membrane protein {ECO:0000269|PubMed:16820410}. Note=In spermatazoa is localized in the midpiece and is translocated to the head region upon receptor stimulation with bourgeonal.


uniprotID: P04001
geneSymbol: OPN1MW
reactome: R-HSA-2187335;R-HSA-2453864;R-HSA-418594;R-HSA-419771;
pdb: 1KPW;
name: Medium-wave-sensitive opsin 1 (Green cone photoreceptor pigment) (Green-sensitive opsin) (GOP)
length: 364
go: ENSG00000268221;
snps: rs104894915 rs267606927 rs104894914 rs104894916
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; photoreceptor disc membrane [GO:0097381]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; G protein-coupled photoreceptor activity [GO:0008020]; identical protein binding [GO:0042802]; photoreceptor activity [GO:0009881]; cellular response to light stimulus [GO:0071482]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction [GO:0007602]; positive regulation of cytokinesis [GO:0032467]; protein-chromophore linkage [GO:0018298]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20579627}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q8NGY9
geneSymbol: OR2L8
reactome: R-HSA-381753;
name: Olfactory receptor 2L8 (Olfactory receptor OR1-46)
length: 312
snps: rs4925788 rs4925790 rs4925583 rs4925792 rs10888282 rs74155337
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGB4
geneSymbol: OR4S1
reactome: R-HSA-381753;
name: Olfactory receptor 4S1 (Olfactory receptor OR11-100)
length: 309
go: ENSG00000176555;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGU1
geneSymbol: OR9A1P
reactome: R-HSA-381753;
name: Putative olfactory receptor 9A1 (HSHTPRX06)
length: 263
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q8NGT5
geneSymbol: OR9A2
reactome: R-HSA-381753;
name: Olfactory receptor 9A2 (Olfactory receptor OR7-2)
length: 310
go: ENSG00000179468;
snps: rs9885986
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: P47883
geneSymbol: OR3A4P
reactome: R-HSA-381753;
name: Putative olfactory receptor 3A4 (Olfactory receptor 17-24) (OR17-24) (Olfactory receptor 3A5)
length: 348
snps: rs9905684 rs9905086 rs9903671 rs9906179 rs9911226 rs9912090 rs2855677 rs231678 rs231677 rs8076130
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


