# annotation

uniprotID: P55327
geneSymbol: TPD52
reactome: R-HSA-432722;
name: Tumor protein D52 (Protein N8)
length: 224
go: ENSG00000076554;
snps: rs35099105
sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; anatomical structure morphogenesis [GO:0009653]; B cell differentiation [GO:0030183]; secretion [GO:0046903]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=P55327-1; Sequence=Displayed; Name=2; IsoId=P55327-2; Sequence=VSP_035751; Name=3; Synonyms=N8L; IsoId=P55327-3; Sequence=VSP_037378; Name=4; IsoId=P55327-4; Sequence=VSP_035751, VSP_043510; Note=No experimental confirmation available.; Name=5; Synonyms=PrLZ-238; IsoId=P55327-5; Sequence=VSP_047719; Name=6; Synonyms=PrLZ-247; IsoId=P55327-6; Sequence=VSP_043510; Name=7; Synonyms=PrLZ-233; IsoId=P55327-7; Sequence=VSP_047720; Name=8; Synonyms=PrLZ-151; IsoId=P55327-8; Sequence=VSP_047718; Note=Interacts only with YWHAB and YWHAQ among 14-3-3 proteins.; 


uniprotID: O00220
geneSymbol: TNFRSF10A
pdb: 5CIR;
length: 468
go: ENSG00000104689;
snps: rs34737614 rs20577 rs11986840 rs17620 rs20575 rs20576 rs17088980 rs2230229
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
reactome:
R-HSA-140534;R-HSA-202733;R-HSA-3371378;R-HSA-5213460;R-HSA-5218900;R-HSA-6803211;R-HSA-69416;R-HSA-75158;

name:
Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; death receptor activity [GO:0005035]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; TRAIL binding [GO:0045569]; transcription factor binding [GO:0008134]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; leukocyte migration [GO:0050900]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of apoptotic process [GO:0043065]; regulation of apoptotic process [GO:0042981]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; signal transduction [GO:0007165]; TRAIL-activated apoptotic signaling pathway [GO:0036462]


uniprotID: Q6PIZ9
geneSymbol: TRAT1
reactome: R-HSA-1257604;R-HSA-202424;R-HSA-2219530;R-HSA-6811558;
length: 186
go: ENSG00000163519;
snps: rs57744779 rs61585973
name:
T-cell receptor-associated transmembrane adapter 1 (T-cell receptor-interacting molecule) (TRIM) (pp29/30)

sequence:
MSGISGCPFFLWGLLALLGLALVISLIFNISHYVEKQRQDKMYSYSSDHTRVDEYYIEDTPIYGNLDDMISEPMDENCYEQMKARPEKSVNKMQEATPSAQATNETQMCYASLDHSVKGKRRKPRKQNTHFSDKDGDEQLHAIDASVSKTTLVDSFSPESQAVEENIHDDPIRLFGLIRAKREPIN

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; T cell receptor complex [GO:0042101]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; adaptive immune response [GO:0002250]; cellular defense response [GO:0006968]; negative regulation of receptor recycling [GO:0001920]; negative regulation of transport [GO:0051051]; positive regulation of calcium-mediated signaling [GO:0050850]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of T cell receptor signaling pathway [GO:0050862]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9687533}; Single-pass type III membrane protein {ECO:0000269|PubMed:9687533}.


uniprotID: Q96RJ3
geneSymbol: TNFRSF13C
reactome: R-HSA-5668541;R-HSA-5676594;
pdb: 1MPV;1OQE;1OSX;2HFG;3V56;4V46;
length: 184
go: ENSG00000159958;
snps: rs547352394 rs61756766
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
name:
Tumor necrosis factor receptor superfamily member 13C (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)

sequence:
MRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAGASSPAPRTALQPQESVGAGAGEAALPLPGLLFGAPALLGLALVLALVLVGLVSWRRRQRRLRGASSAEAPDGDKDAPEPLDKVIILSPGISDATAPAWPPPGEDPGTTPPGHSVPVPATELGSTELVTTKTAGPEQQ

opentargets:
external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; B cell costimulation [GO:0031296]; B cell homeostasis [GO:0001782]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of germinal center formation [GO:0002636]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of T cell proliferation [GO:0042102]; T cell costimulation [GO:0031295]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96RJ3-1; Sequence=Displayed; Name=2; IsoId=Q96RJ3-2; Sequence=VSP_006505; Note=No experimental confirmation available.; 


uniprotID: Q8IWZ5
geneSymbol: TRIM42
name: Tripartite motif-containing protein 42
length: 723
go: ENSG00000155890;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
snps: rs698673 rs28594654 rs9876490
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWZ5-1; Sequence=Displayed; Name=2; IsoId=Q8IWZ5-2; Sequence=VSP_012066, VSP_012067; Note=No experimental confirmation available.; 


uniprotID: Q9BUZ4
geneSymbol: TRAF4
pdb: 2EOD;2YUC;3ZJB;4K8U;4M4E;5YC1;
length: 470
go: ENSG00000076604;
snps: rs35932778 rs1044066
name:
TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83)

sequence:

opentargets:
bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein kinase binding [GO:0019901]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; WW domain binding [GO:0050699]; zinc ion binding [GO:0008270]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein kinase activity [GO:0045860]; regulation of apoptotic process [GO:0042981]; respiratory gaseous exchange [GO:0007585]; respiratory tube development [GO:0030323]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BUZ4-1; Sequence=Displayed; Name=2; Synonyms=TRAF4 variant 5; IsoId=Q9BUZ4-2; Sequence=VSP_007403; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.


uniprotID: O00463
geneSymbol: TRAF5
name: TNF receptor-associated factor 5 (RING finger protein 84)
length: 557
go: ENSG00000082512;
snps: rs3946808 rs2271458 rs200398415 rs2230780
sequence:

opentargets:
CD40 receptor complex [GO:0035631]; centrosome [GO:0005813]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O00463-1; Sequence=Displayed; Name=2; IsoId=O00463-2; Sequence=VSP_055449; Note=No experimental confirmation available.; Name=3; IsoId=O00463-3; Sequence=VSP_055450; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15121867}. Cytoplasm, cytosol {ECO:0000269|PubMed:15121867}.


uniprotID: Q6ZMU5
geneSymbol: TRIM72
reactome: R-HSA-445355;
pdb: 3KB5;
name: Tripartite motif-containing protein 72 (Mitsugumin-53) (Mg53)
length: 477
go: ENSG00000177238;
sequence:

opentargets:
cytoplasmic vesicle membrane [GO:0030659]; sarcolemma [GO:0042383]; phosphatidylserine binding [GO:0001786]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; exocytosis [GO:0006887]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; muscle system process [GO:0003012]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of insulin-like growth factor receptor signaling pathway [GO:0043569]; negative regulation of myotube differentiation [GO:0010832]; plasma membrane repair [GO:0001778]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein homooligomerization [GO:0051260]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:14702039}; IsoId=Q6ZMU5-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=Q6ZMU5-2; Sequence=VSP_052318; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.


uniprotID: Q8NG06
geneSymbol: TRIM58
length: 486
go: ENSG00000162722;
snps: rs11204523 rs1339847 rs3811444
name:
E3 ubiquitin-protein ligase TRIM58 (EC 2.3.2.27) (Protein BIA2) (RING-type E3 ubiquitin transferase TRIM58) (Tripartite motif-containing protein 58)

sequence:

opentargets:
intracellular [GO:0005622]; dynein heavy chain binding [GO:0045504]; dynein intermediate chain binding [GO:0045505]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; positive regulation of erythrocyte enucleation [GO:0061931]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; regulation of nuclear migration along microtubule [GO:1902838]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q8IWR1
geneSymbol: TRIM59
name: Tripartite motif-containing protein 59 (RING finger protein 104) (Tumor suppressor TSBF-1)
length: 403
go: ENSG00000213186;
sequence:

opentargets:
centrosome [GO:0005813]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intraciliary transport particle B [GO:0030992]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of viral entry into host cell [GO:0046597]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWR1-1; Sequence=Displayed; Name=IFT80-L; IsoId=Q9P2H3-3; Sequence=External; Note=Based on a naturally occurring readthrough transcript which produces a TRIM59-IFT80 fusion protein.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q922Y2}; Single-pass membrane protein {ECO:0000305}.


uniprotID: Q13049
geneSymbol: TRIM32
reactome: R-HSA-3134975;R-HSA-983168;
pdb: 2CT2;5FEY;
length: 653
go: ENSG00000119401;
snps: rs111033571 rs3747834 rs766439806 rs121434447 rs3747835 rs111033570
name:
E3 ubiquitin-protein ligase TRIM32 (EC 2.3.2.27) (72 kDa Tat-interacting protein) (RING-type E3 ubiquitin transferase TRIM32) (Tripartite motif-containing protein 32) (Zinc finger protein HT2A)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; striated muscle myosin thick filament [GO:0005863]; identical protein binding [GO:0042802]; myosin binding [GO:0017022]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; Tat protein binding [GO:0030957]; transcription coactivator activity [GO:0003713]; translation initiation factor binding [GO:0031369]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; actin ubiquitination [GO:0007014]; axon development [GO:0061564]; fat cell differentiation [GO:0045444]; innate immune response [GO:0045087]; muscle cell cellular homeostasis [GO:0046716]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell motility [GO:2000147]; positive regulation of chemokine (C-C motif) ligand 20 production [GO:1903886]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-17-mediated signaling pathway [GO:1903883]; positive regulation of neurogenesis [GO:0050769]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of proteolysis [GO:0045862]; positive regulation of striated muscle cell differentiation [GO:0051155]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]; response to tumor necrosis factor [GO:0034612]; response to UV [GO:0009411]; tissue homeostasis [GO:0001894]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in cytoplasmic bodies, often located around the nucleus.


uniprotID: P07477
geneSymbol: PRSS1
reactome: R-HSA-1592389;R-HSA-196741;
pdb: 1FXY;1TRN;2RA3;4WWY;4WXV;
length: 247
go: ENSG00000204983;
location: SUBCELLULAR LOCATION: Secreted, extracellular space.
name:
Trypsin-1 (EC 3.4.21.4) (Beta-trypsin) (Cationic trypsinogen) (Serine protease 1) (Trypsin I) [Cleaved into: Alpha-trypsin chain 1; Alpha-trypsin chain 2]

sequence:

opentargets:
blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; cobalamin metabolic process [GO:0009235]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]

drug:
DB06850;DB07091;DB06845;DB07088;DB07131;DB07095;DB07985;DB03337;DB04336;DB03417;DB08420;DB01905;DB02193;DB02463;DB02287;DB08184;DB06918;DB06923;DB08254;DB04325;DB04410;DB07368;DB03243;DB03136;DB04311;DB04654;DB02354;DB01939;DB03865;DB04107;DB02269;DB08763;DB04391;DB02435;DB02045;DB06692;DB03127;DB04446;DB02464;DB03213;DB04301;DB01876;DB01705;DB04008;DB03443;DB02081;DB03173;DB02526;DB04470;DB02366;DB03494;DB02989;DB01771;DB03555;DB03643;DB02063;DB02084;DB01741;DB03016;DB02875;DB04246;DB01725;DB03159;DB04215;DB02288;DB04563;DB03595;DB03081;DB04269;DB03608;DB01767;DB01805;DB04125;DB01745;DB04238;DB06853;DB06858;DB03976;DB04424;DB02744;DB03251;DB02665;DB01665;DB04432;DB02112;DB03373;

snps:
rs202003805 rs397507442 rs111033567 rs111033566 rs111033566 rs144422014 rs111033564 rs387906698 rs111033568 rs267606982 rs117497341 


uniprotID: P07478
geneSymbol: PRSS2
reactome: R-HSA-1442490;R-HSA-1462054;R-HSA-1592389;R-HSA-6798695;R-HSA-6803157;
name: Trypsin-2 (EC 3.4.21.4) (Anionic trypsinogen) (Serine protease 2) (Trypsin II)
length: 247
go: ENSG00000275896;
drug: DB04325;DB04410;DB03127;DB02464;DB02325;DB01805;DB01973;DB03976;
snps: rs11547028 rs1804564
location: SUBCELLULAR LOCATION: Secreted, extracellular space.
sequence:

opentargets:
azurophil granule lumen [GO:0035578]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; antimicrobial humoral response [GO:0019730]; collagen catabolic process [GO:0030574]; digestion [GO:0007586]; extracellular matrix disassembly [GO:0022617]; neutrophil degranulation [GO:0043312]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell growth [GO:0030307]; proteolysis [GO:0006508]


uniprotID: P35030
geneSymbol: PRSS3
reactome: R-HSA-1462054;R-HSA-196741;R-HSA-6798695;R-HSA-6803157;
pdb: 1H4W;2R9P;3L33;3L3T;3P92;3P95;4DG4;4U30;4U32;5C67;5JBT;5TP0;
length: 304
go: ENSG00000010438;
drug: DB02585;DB02541;DB03127;DB03637;
snps: rs11547028 rs855581 rs1063273 rs1048379
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6698368}.
name:
Trypsin-3 (EC 3.4.21.4) (Brain trypsinogen) (Mesotrypsin) (Mesotrypsinogen) (Serine protease 3) (Serine protease 4) (Trypsin III) (Trypsin IV)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; tertiary granule lumen [GO:1904724]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; antimicrobial humoral response [GO:0019730]; cobalamin metabolic process [GO:0009235]; digestion [GO:0007586]; endothelial cell migration [GO:0043542]; neutrophil degranulation [GO:0043312]; proteolysis [GO:0006508]; zymogen activation [GO:0031638]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=A; IsoId=P35030-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P35030-2; Sequence=VSP_042074; Name=3; Synonyms=C; IsoId=P35030-3; Sequence=VSP_005410; Name=4; Synonyms=D; IsoId=P35030-4; Sequence=VSP_005409; Name=5; Synonyms=E; IsoId=P35030-5; Sequence=VSP_053779; 


uniprotID: Q6ZSZ6
geneSymbol: TSHZ1
name: Teashirt homolog 1 (Antigen NY-CO-33) (Serologically defined colon cancer antigen 33)
length: 1077
go: ENSG00000179981;
snps: rs55679337
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; anterior/posterior pattern specification [GO:0009952]; middle ear morphogenesis [GO:0042474]; regulation of transcription by RNA polymerase II [GO:0006357]; soft palate development [GO:0060023]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZSZ6-1; Sequence=Displayed; Name=2; IsoId=Q6ZSZ6-2; Sequence=VSP_040877; 


uniprotID: Q86UF1
geneSymbol: TSPAN33
name: Tetraspanin-33 (Tspan-33) (Penumbra) (hPen) (Proerythroblast new membrane)
length: 283
go: ENSG00000158457;
sequence:

opentargets:
cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; tetraspanin-enriched microdomain [GO:0097197]; enzyme binding [GO:0019899]; cell surface receptor signaling pathway [GO:0007166]; protein localization to plasma membrane [GO:0072659]; protein maturation [GO:0051604]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q2NL82
geneSymbol: TSR1
reactome: R-HSA-6791226;
pdb: 6G18;6G4S;6G4W;6G51;6G53;
name: Pre-rRNA-processing protein TSR1 homolog
length: 804
go: ENSG00000167721;
snps: rs2281726 rs2273983 rs35019711 rs35343613
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; U3 snoRNA binding [GO:0034511]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]


uniprotID: P41732
geneSymbol: TSPAN7
reactome: R-HSA-202733;R-HSA-416993;
length: 249
go: ENSG00000156298;
snps: rs17851592 rs17851593 rs104894951
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; cell surface receptor signaling pathway [GO:0007166]; viral process [GO:0016032]


uniprotID: Q96NA8
geneSymbol: TSNARE1
name: t-SNARE domain-containing protein 1
length: 513
go: ENSG00000171045;
snps: rs7814359 rs33970858 rs10100935 rs10435683
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
endomembrane system [GO:0012505]; integral component of membrane [GO:0016021]; SNARE complex [GO:0031201]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; intracellular protein transport [GO:0006886]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96NA8-1; Sequence=Displayed; Name=2; IsoId=Q96NA8-2; Sequence=VSP_056304; Note=No experimental confirmation available.; 


uniprotID: Q8NFU3
geneSymbol: TSTD1
reactome: R-HSA-1614517;
pdb: 6BEV;
name: Thiosulfate:glutathione sulfurtransferase (TST) (EC 2.8.1.-)
length: 115
go: ENSG00000215845;
sequence:
MAGAPTVSLPELRSLLASGRARLFDVRSREEAAAGTIPGALNIPVSELESALQMEPAAFQALYSAEKPKLEDEHLVFFCQMGKRGLQATQLARSLGYTGARNYAGAYREWLEKES

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; thiosulfate-thiol sulfurtransferase activity [GO:0050337]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:12817473}; IsoId=Q8NFU3-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12817473}; IsoId=Q8NFU3-2; Sequence=VSP_014152; Name=3 {ECO:0000303|PubMed:12817473}; IsoId=Q8NFU3-3; Sequence=VSP_014153; Name=4; IsoId=Q8NFU3-4; Sequence=VSP_014151; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:12817473}. Note=Localized around the nuclear membranes.


uniprotID: Q5TGU0
geneSymbol: TSPO2
name: Translocator protein 2 (Peripheral-type benzodiazepine receptor-like protein 1)
length: 170
go: ENSG00000112212;
sequence:
MRLQGAIFVLLPHLGPILVWLFTRDHMSGWCEGPRMLSWCPFYKVLLLVQTAIYSVVGYASYLVWKDLGGGLGWPLALPLGLYAVQLTISWTVLVLFFTVHNPGLALLHLLLLYGLVVSTALIWHPINKLAALLLLPYLAWLTVTSALTYHLWRDSLCPVHQPQPTEKSD

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; cholesterol binding [GO:0015485]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TGU0-1; Sequence=Displayed; Name=2; IsoId=Q5TGU0-2; Sequence=VSP_026363, VSP_026364; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19729679}; Multi-pass membrane protein {ECO:0000269|PubMed:19729679}.


uniprotID: Q9H0U9
geneSymbol: TSPYL1
name: Testis-specific Y-encoded-like protein 1 (TSPY-like protein 1)
length: 437
go: ENSG00000189241;
snps: rs3828743 rs3749895 rs3749894
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; nucleosome assembly [GO:0006334]


uniprotID: Q92623
geneSymbol: TTC9
name: Tetratricopeptide repeat protein 9A (TPR repeat protein 9A)
length: 222
go: ENSG00000133985;
opentargets: bone development [GO:0060348]
snps: rs4902834
sequence:


uniprotID: Q96AY4
geneSymbol: TTC28
length: 2481
go: ENSG00000100154;
name:
Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio)

sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]; kinase binding [GO:0019900]; cell cycle [GO:0007049]; cell division [GO:0051301]; regulation of mitotic cell cycle [GO:0007346]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Midbody {ECO:0000250}. Note=At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity). {ECO:0000250}.


uniprotID: Q9H313
geneSymbol: TTYH1
reactome: R-HSA-2672351;
name: Protein tweety homolog 1 (hTTY1)
length: 450
go: ENSG00000167614;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
chloride channel complex [GO:0034707]; filopodium membrane [GO:0031527]; filopodium tip [GO:0032433]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; synapse [GO:0045202]; calcium ion binding [GO:0005509]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; iron ion transmembrane transporter activity [GO:0005381]; volume-sensitive chloride channel activity [GO:0072320]; cell-cell adhesion [GO:0098609]; cell-substrate adhesion [GO:0031589]; chloride transport [GO:0006821]; filopodium assembly [GO:0046847]; ion transmembrane transport [GO:0034220]; iron ion transport [GO:0006826]; mitotic cell cycle [GO:0000278]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9H313-1; Sequence=Displayed; Name=2; IsoId=Q9H313-2; Sequence=VSP_029760; Name=3; Synonyms=TTYH1s; IsoId=Q9H313-3; Sequence=VSP_029759; Name=4; IsoId=Q9H313-4; Sequence=VSP_029753, VSP_029757, VSP_029760; Note=No experimental confirmation available.; Name=5; IsoId=Q9H313-5; Sequence=VSP_029754, VSP_029755, VSP_029756, VSP_029758; Note=No experimental confirmation available.; 


uniprotID: Q9C0H2
geneSymbol: TTYH3
reactome: R-HSA-2672351;
name: Protein tweety homolog 3 (hTTY3)
length: 523
go: ENSG00000136295;
sequence:

opentargets:
chloride channel complex [GO:0034707]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; chloride channel activity [GO:0005254]; intracellular calcium activated chloride channel activity [GO:0005229]; volume-sensitive chloride channel activity [GO:0072320]; chloride transport [GO:0006821]; ion transmembrane transport [GO:0034220]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9C0H2-1; Sequence=Displayed; Name=2; IsoId=Q9C0H2-2; Sequence=VSP_029770; Note=No experimental confirmation available.; Name=3; IsoId=Q9C0H2-3; Sequence=VSP_029769; Note=No experimental confirmation available.; Name=4; IsoId=Q9C0H2-4; Sequence=VSP_042220; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15010458}; Multi-pass membrane protein {ECO:0000269|PubMed:15010458}.


uniprotID: Q8NHH1
geneSymbol: TTLL11
reactome: R-HSA-8955332;
name: Tubulin polyglutamylase TTLL11 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 11)
length: 800
go: ENSG00000175764;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A4Q9F4}.
sequence:

opentargets:
cilium [GO:0005929]; cytosol [GO:0005829]; microtubule [GO:0005874]; ATP binding [GO:0005524]; tubulin-glutamic acid ligase activity [GO:0070740]; microtubule severing [GO:0051013]; protein polyglutamylation [GO:0018095]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NHH1-1; Sequence=Displayed; Name=2; IsoId=Q8NHH1-2; Sequence=VSP_057853, VSP_057854; 


uniprotID: O00294
geneSymbol: TULP1
pdb: 2FIM;3C5N;
name: Tubby-related protein 1 (Tubby-like protein 1)
length: 542
go: ENSG00000112041;
sequence:

opentargets:
axon terminus [GO:0043679]; cell junction [GO:0030054]; cell projection [GO:0042995]; cilium [GO:0005929]; cytosol [GO:0005829]; extracellular region [GO:0005576]; photoreceptor inner segment [GO:0001917]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; synapse [GO:0045202]; actin filament binding [GO:0051015]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; dendrite development [GO:0016358]; detection of light stimulus involved in visual perception [GO:0050908]; eye photoreceptor cell development [GO:0042462]; phagocytosis, recognition [GO:0006910]; photoreceptor cell maintenance [GO:0045494]; positive regulation of phagocytosis [GO:0050766]; protein localization to cilium [GO:0061512]; protein localization to photoreceptor outer segment [GO:1903546]; receptor localization to non-motile cilium [GO:0097500]; retina development in camera-type eye [GO:0060041]; retina homeostasis [GO:0001895]; visual perception [GO:0007601]

snps:
rs7764472 rs62636707 rs2064317 rs2064318 rs387906837 rs148749577 rs121909076 rs387906836 rs121909073 rs138200747 rs121909075 rs121909077 rs62636511 rs121909074 rs141980901 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00294-1; Sequence=Displayed; Name=2; IsoId=O00294-2; Sequence=VSP_023031; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16303976}. Cell membrane {ECO:0000269|PubMed:16303976}; Peripheral membrane protein {ECO:0000269|PubMed:16303976}; Cytoplasmic side {ECO:0000269|PubMed:16303976}. Secreted {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Detected at synapses between photoreceptor cells and second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By similarity). {ECO:0000250}.


uniprotID: Q5TAX3
geneSymbol: TUT4
reactome: R-HSA-429947;
length: 1644
go: ENSG00000134744;
snps: rs12127732
name:
Terminal uridylyltransferase 4 (TUTase 4) (EC 2.7.7.52) (Zinc finger CCHC domain-containing protein 11)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; zinc ion binding [GO:0008270]; miRNA catabolic process [GO:0010587]; miRNA metabolic process [GO:0010586]; negative regulation of transposition, RNA-mediated [GO:0010526]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; oocyte maturation [GO:0001556]; polyuridylation-dependent mRNA catabolic process [GO:1990074]; pre-miRNA processing [GO:0031054]; RNA 3' uridylation [GO:0071076]; RNA 3'-end processing [GO:0031123]; stem cell population maintenance [GO:0019827]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TAX3-1; Sequence=Displayed; Name=2; IsoId=Q5TAX3-2; Sequence=VSP_038135, VSP_038136; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16643855}. Cytoplasm {ECO:0000269|PubMed:16643855, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:25480299}. Note=Mainly cytoplasmic (PubMed:19703396, PubMed:25480299). Translocates into the cytoplasm following treatment of the cell with LPS (PubMed:16643855).


uniprotID: Q9P2J2
geneSymbol: IGSF9
pdb: 1V5J;
name: Protein turtle homolog A (Immunoglobulin superfamily member 9A) (IgSF9A)
length: 1179
go: ENSG00000085552;
snps: rs3747617 rs16842846 rs35574000 rs34749866 rs1319080
sequence:

opentargets:
axon [GO:0030424]; cell junction [GO:0030054]; dendrite [GO:0030425]; inhibitory synapse [GO:0060077]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cell-cell adhesion mediator activity [GO:0098632]; axon guidance [GO:0007411]; dendrite development [GO:0016358]; dendrite self-avoidance [GO:0070593]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; regulation of synapse organization [GO:0050807]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P2J2-1; Sequence=Displayed; Name=2; IsoId=Q9P2J2-2; Sequence=VSP_047195; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.


uniprotID: Q9UPX0
geneSymbol: IGSF9B
name: Protein turtle homolog B (Immunoglobulin superfamily member 9B) (IgSF9B)
length: 1349
go: ENSG00000080854;
snps: rs77432041 rs369063193
sequence:

opentargets:
cell junction [GO:0030054]; dendrite [GO:0030425]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; postsynaptic specialization of symmetric synapse [GO:0099629]; kinase binding [GO:0019900]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; synaptic membrane adhesion [GO:0099560]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UPX0-1; Sequence=Displayed; Name=2; IsoId=Q9UPX0-2; Sequence=VSP_054730; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:D3ZB51}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:D3ZB51}.


uniprotID: A0A0K0K1A3
geneSymbol: TRBV10-1
name: T cell receptor beta variable 10-1
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLFFYVALCLLWAGHRDAEITQSPRHKITETGRQVTLACHQTWNHNNMFWYRQDLGHGLRLIHYSYGVHDTNKGEVSDGYSVSRSNTEDLPLTLESAASSQTSVYFCASSE


uniprotID: A0A584
geneSymbol: TRBV11-2
name: T cell receptor beta variable 11-2
length: 115
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLLCWAALCLLGAELTEAGVAQSPRYKIIEKRQSVAFWCNPISGHATLYWYQQILGQGPKLLIQFQNNGVVDDSQLPKDRFSAERLKGVDSTLKIQPAKLEDSAVYLCASSL


uniprotID: P01733
geneSymbol: TRBV12-3
reactome: R-HSA-198933;R-HSA-202424;R-HSA-202427;R-HSA-202430;R-HSA-202433;R-HSA-389948;
name: T cell receptor beta variable 12-3 (T-cell receptor beta chain V region YT35)
length: 115
go: ENSG00000274752;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MDSWTFCCVSLCILVAKHTDAGVIQSPRHEVTEMGQEVTLRCKPISGHNSLFWYRQTMMRGLELLIYFNNNVPIDDSGMPEDRFSAKMPNASFSTLKIQPSEPRDSAVYFCASSL


uniprotID: A0A1B0GX78
geneSymbol: TRBV12-5
name: T cell receptor beta variable 12-5
length: 115
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MATRLLCCVVLCLLGEELIDARVTQTPRHKVTEMGQEVTMRCQPILGHNTVFWYRQTMMQGLELLAYFRNRAPLDDSGMPKDRFSAEMPDATLATLKIQPSEPRDSAVYFCASGL


uniprotID: A0A075B6N2
geneSymbol: TRBV20-1
name: T cell receptor beta variable 20-1
length: 111
go: ENSG00000211747;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLLLLLLGPGSGLGAVVSQHPSRVICKSGTSVKIECRSLDFQATTMFWYRQFPKQSLMLMATSNEGSKATYEQGVEKDKFLINHASLTLSTLTVTSAHPEDSSFYICSAR


uniprotID: A0A0B4J264
geneSymbol: TRAV38-1
name: T cell receptor alpha variable 38-1
length: 116
go: ENSG00000211816;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MTRVSLLWAVVVSTCLESGMAQTVTQSQPEMSVQEAETVTLSCTYDTSENNYYLFWYKQPPSRQMILVIRQEAYKQQNATENRFSVNFQKAAKSFSLKISDSQLGDTAMYFCAFMK


uniprotID: A0A087WT03
geneSymbol: TRAV26-1
name: T cell receptor alpha variable 26-1
length: 109
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MRLVARVTVFLTFGTIIDAKTTQPTSMDCAEGRAANLPCNHSTISGNEYVYWYRQIHSQGPQYIIHGLKNNETNEMASLIITEDRKSSTLILPHATLRDTAVYYCIVRV


uniprotID: A0A0B4J238
geneSymbol: TRAV1-2
name: T cell receptor alpha variable 1-2
length: 106
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MWGVFLLYVSMKMGGTTGQNIDQPTEMTATEGAIVQINCTYQTSGFNGLFWYQQHAGEAPTFLSYNVLDGLEEKGRFSSFLSRSKGYSYLLLKELQMKDSASYLCA


uniprotID: A0A087WV62
geneSymbol: TRBV16
name: T cell receptor beta variable 16
length: 115
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSPIFTCITILCLLAAGSPGEEVAQTPKHLVRGEGQKAKLYCAPIKGHSYVFWYQQVLKNEFKFLISFQNENVFDETGMPKERFSAKCLPNSPCSLEIQATKLEDSAVYFCASSQ


uniprotID: A0A5B6
geneSymbol: TRBV28
pdb: 4ZDH;
name: T cell receptor beta variable 28
length: 114
go: ENSG00000211753;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGIRLLCRVAFCFLAVGLVDVKVTQSSRYLVKRTGEKVFLECVQDMDHENMFWYRQDPGLGLRLIYFSYDVKMKEKGDIPEGYSVSREKKERFSLILESASTNQTSMYLCASSL


uniprotID: A0A1B0GX68
geneSymbol: TRBV2
name: T cell receptor beta variable 2
length: 115
go: ENSG00000226660;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MDTWLVCWAIFSLLKAGLTEPEVTQTPSHQVTQMGQEVILRCVPISNHLYFYWYRQILGQKVEFLVSFYNNEISEKSEIFDDQFSVERPDGSNFTLKIRSTKLEDSAMYFCASSE


uniprotID: A0A0B4J276
geneSymbol: TRAV25
name: T cell receptor alpha variable 25
length: 109
go: ENSG00000211806;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MLLITSMLVLWMQLSQVNGQQVMQIPQYQHVQEGEDFTTYCNSSTTLSNIQWYKQRPGGHPVFLIQLVKSGEVKKQKRLTFQFGEAKKNSSLHITATQTTDVGTYFCAG


uniprotID: A0A0C4DH59
geneSymbol: TRBV5-4
name: T cell receptor beta variable 5-4
length: 114
go: ENSG00000230099;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGPGLLCWALLCLLGAGSVETGVTQSPTHLIKTRGQQVTLRCSSQSGHNTVSWYQQALGQGPQFIFQYYREEENGRGNFPPRFSGLQFPNYSSELNVNALELDDSALYLCASSL


uniprotID: A0A0B4J263
geneSymbol: TRAV39
name: T cell receptor alpha variable 39
length: 110
go: ENSG00000211818;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MKKLLAMILWLQLDRLSGELKVEQNPLFLSMQEGKNYTIYCNYSTTSDRLYWYRQDPGKSLESLFVLLSNGAVKQEGRLMASLDTKARLSTLHITAAVHDLSATYFCAVD


uniprotID: A0A0B4J266
geneSymbol: TRAV41
name: T cell receptor alpha variable 41
length: 112
go: ENSG00000211820;
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MVKIRQFLLAILWLQLSCVSAAKNEVEQSPQNLTAQEGEFITINCSYSVGISALHWLQQHPGGGIVSLFMLSSGKKKHGRLIATINIQEKHSSLHITASHPRDSAVYICAVR


uniprotID: A0A0K0K1A5
geneSymbol: TRBV6-5
pdb: 1AO7;1BD2;2BNQ;2BNR;2BNU;4WWK;
name: T cell receptor beta variable 6-5
length: 114
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSIGLLCCAALSLLWAGPVNAGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGMGLRLIHYSVGAGITDQGEVPNGYNVSRSTTEDFPLRLLSAAPSQTSVYFCASSY


uniprotID: A0A0A6YYG3
geneSymbol: TRBV6-8
name: T cell receptor beta variable 6-8
length: 113
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MSLGLLCCAAFSLLWAGPVNAGVTQTPKFHILKTGQSMTLQCAQDMNHGYMSWYRQDPGMGLRLIYYSAAAGTTDKEVPNGYNVSRLNTEDFPLRLVSAAPSQTSVYLCASSY


uniprotID: A0A1B0GX95
geneSymbol: TRBV7-4
name: T cell receptor beta variable 7-4
length: 115
opentargets: plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
sequence:
MGTRLLCWVVLGFLGTDHTGAGVSQSPRYKVAKRGRDVALRCDSISGHVTLYWYRQTLGQGSEVLTYSQSDAQRDKSGRPSGRFSAERPERSVSTLKIQRTEQGDSAVYLCASSL


uniprotID: Q5T292
geneSymbol: TMEM273
name: Transmembrane protein 273
length: 105
go: ENSG00000204161;
opentargets: integral component of membrane [GO:0016021]
snps: rs12257132
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
sequence:
MNLGVSMLRILFLLDVGGAQVLATGKTPGAEIDFKYALIGTAVGVAISAGFLALKICMIRRHLFDDDSSDLKSTPGGLSDTIPLKKRAPRRNHNFSKRDAQVIEL

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5T292-1; Sequence=Displayed; Name=2; IsoId=Q5T292-2; Sequence=VSP_028715; Note=No experimental confirmation available.; Name=3; IsoId=Q5T292-3; Sequence=VSP_028716; Name=4; IsoId=Q5T292-4; Sequence=VSP_028717; 


uniprotID: P23510
geneSymbol: TNFSF4
reactome: R-HSA-5669034;
pdb: 2HEV;
length: 183
go: ENSG00000117586;
location: SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
name:
Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)

sequence:
MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL

opentargets:
cell surface [GO:0009986]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; acute inflammatory response [GO:0002526]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to prostaglandin E stimulus [GO:0071380]; chemokine (C-C motif) ligand 11 production [GO:0071954]; defense response to nematode [GO:0002215]; immune response [GO:0006955]; inflammatory response [GO:0006954]; memory T cell activation [GO:0035709]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of regulatory T cell differentiation [GO:0045590]; negative regulation of T-helper 1 cell differentiation [GO:0045626]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of alpha-beta T cell proliferation [GO:0046641]; positive regulation of B cell activation [GO:0050871]; positive regulation of CD4-positive, alpha-beta T cell costimulation [GO:1900281]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cell proliferation [GO:0008284]; positive regulation of immunoglobulin mediated immune response [GO:0002891]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-4-dependent isotype switching to IgE isotypes [GO:2000572]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of memory T cell differentiation [GO:0043382]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of type 2 immune response [GO:0002830]; regulation of adaptive immune response [GO:0002819]; regulation of inflammatory response [GO:0050727]; response to nitrogen dioxide [GO:0035713]; response to virus [GO:0009615]; signal transduction [GO:0007165]; T-helper 2 cell activation [GO:0035712]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P23510-1; Sequence=Displayed; Name=2; IsoId=P23510-2; Sequence=VSP_056288; 


uniprotID: Q8N2U0
geneSymbol: TMEM256
name: Transmembrane protein 256
length: 113
go: ENSG00000205544;
opentargets: extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MAGPAAAFRRLGALSGAAALGFASYGAHGAQFPDAYGKELFDKANKHHFLHSLALLGVPHCRKPLWAGLLLASGTTLFCTSFYYQALSGDPSIQTLAPAGGTLLLLGWLALAL


uniprotID: Q9NW97
geneSymbol: TMEM51
name: Transmembrane protein 51
length: 253
go: ENSG00000171729;
opentargets: integral component of membrane [GO:0016021]
snps: rs17405421 rs3766158
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q6P589
geneSymbol: TNFAIP8L2
reactome: R-HSA-1483255;
pdb: 3F4M;
length: 184
go: ENSG00000163154;
name:
Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)

sequence:
MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVIKDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLLTECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLDEGKL

opentargets:
cytoplasm [GO:0005737]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of T cell activation [GO:0050868]; regulation of apoptotic process [GO:0042981]


uniprotID: P32971
geneSymbol: TNFSF8
reactome: R-HSA-5669034;
name: Tumor necrosis factor ligand superfamily member 8 (CD30 ligand) (CD30-L) (CD antigen CD153)
length: 234
go: ENSG00000106952;
location: SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
sequence:

opentargets:
extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; CD8-positive, alpha-beta T cell differentiation [GO:0043374]; cell proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; defense response to Gram-positive bacterium [GO:0050830]; immune response [GO:0006955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: O43399
geneSymbol: TPD52L2
name: Tumor protein D54 (hD54) (Tumor protein D52-like 2)
length: 206
go: ENSG00000101150;
sequence:

opentargets:
cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; catalytic activity [GO:0003824]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; regulation of cell proliferation [GO:0042127]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=HD54+ins2; IsoId=O43399-1; Sequence=Displayed; Name=2; Synonyms=HD54-ins2; IsoId=O43399-2; Sequence=VSP_006547; Name=3; IsoId=O43399-3; Sequence=VSP_006547, VSP_036756; Name=4; IsoId=O43399-4; Sequence=VSP_006547, VSP_038361; Name=5; IsoId=O43399-5; Sequence=VSP_038361; Note=No experimental confirmation available.; Name=6; IsoId=O43399-6; Sequence=VSP_045154, VSP_006547; Name=7; IsoId=O43399-7; Sequence=VSP_047409; Note=No experimental confirmation available.; 


uniprotID: Q8WVT3
geneSymbol: TRAPPC12
reactome: R-HSA-8876198;
length: 735
go: ENSG00000171853;
snps: rs11686212 rs768950892
name:
Trafficking protein particle complex subunit 12 (Tetratricopeptide repeat protein 15) (TPR repeat protein 15) (TTC-15) (Trafficking of membranes and mitosis)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; kinetochore [GO:0000776]; nucleus [GO:0005634]; TRAPP complex [GO:0030008]; endopeptidase activity [GO:0004175]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; metaphase plate congression [GO:0051310]; positive regulation of protein localization to kinetochore [GO:1905342]; protein complex oligomerization [GO:0051259]; regulation of kinetochore assembly [GO:0090234]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:21525244}. Nucleus {ECO:0000269|PubMed:25918224}. Note=Mainly localizes to structures resembling the Golgi and a small amount is found in the nucleus. {ECO:0000269|PubMed:25918224}.


uniprotID: O95361
geneSymbol: TRIM16
length: 564
go: ENSG00000221926;
snps: rs2074890 rs3174720 rs1060903
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27693506}.
name:
Tripartite motif-containing protein 16 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM16) (Estrogen-responsive B box protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; PML body [GO:0016605]; DNA binding [GO:0003677]; interleukin-1 binding [GO:0019966]; NACHT domain binding [GO:0032089]; zinc ion binding [GO:0008270]; histone H3 acetylation [GO:0043966]; histone H4 acetylation [GO:0043967]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of retinoic acid receptor signaling pathway [GO:0048386]; positive regulation of transcription, DNA-templated [GO:0045893]; response to growth hormone [GO:0060416]; response to organophosphorus [GO:0046683]; response to retinoic acid [GO:0032526]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Alpha; IsoId=O95361-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=O95361-2; Sequence=VSP_009098; 


uniprotID: Q6Q0C0
geneSymbol: TRAF7
reactome: R-HSA-983168;
length: 670
go: ENSG00000131653;
name:
E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)

sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; activation of MAPKKK activity [GO:0000185]; apoptotic process [GO:0006915]; Notch signaling pathway [GO:0007219]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of MAPK cascade [GO:0043410]; protein ubiquitination [GO:0016567]; ribosomal large subunit assembly [GO:0000027]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:15001576}; IsoId=Q6Q0C0-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15001576}; IsoId=Q6Q0C0-2; Sequence=VSP_051607; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.


uniprotID: Q9NQ86
geneSymbol: TRIM36
reactome: R-HSA-983168;
length: 728
go: ENSG00000152503;
snps: rs79290430 rs17137481 rs2974617 rs3749745
name:
E3 ubiquitin-protein ligase TRIM36 (EC 2.3.2.27) (RING finger protein 98) (RING-type E3 ubiquitin transferase TRIM36) (Tripartite motif-containing protein 36) (Zinc-binding protein Rbcc728)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; alpha-tubulin binding [GO:0043014]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; acrosome reaction [GO:0007340]; mitotic cytokinesis [GO:0000281]; protein polyubiquitination [GO:0000209]; regulation of cell cycle [GO:0051726]; regulation of microtubule cytoskeleton organization [GO:0070507]; spindle organization [GO:0007051]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9NQ86-1; Sequence=Displayed; Name=2; IsoId=Q9NQ86-2; Sequence=VSP_043511, VSP_043512; Note=No experimental confirmation available.; Name=3; IsoId=Q9NQ86-3; Sequence=VSP_045791, VSP_045792; Note=No experimental confirmation available.; Name=4; IsoId=Q9NQ86-4; Sequence=VSP_053818; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28087737}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q80WG7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80WG7}. Note=Found in the acrosomal region of elongated spermatids and mature sperm. {ECO:0000250|UniProtKB:Q80WG7}.


uniprotID: Q7Z4N2
geneSymbol: TRPM1
reactome: R-HSA-3295583;
length: 1603
go: ENSG00000134160;
name:
Transient receptor potential cation channel subfamily M member 1 (Long transient receptor potential channel 1) (LTrpC1) (Melastatin-1)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; new growing cell tip [GO:0035841]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport into cytosol [GO:0060402]; cellular response to light stimulus [GO:0071482]; G protein-coupled glutamate receptor signaling pathway [GO:0007216]; protein tetramerization [GO:0051262]; retinal rod cell development [GO:0046548]; visual perception [GO:0007601]

snps:
rs2241493 rs200514769 rs774365264 rs191205969 rs372608320 rs141540242 rs748043795 rs17815774 rs267607139 rs781460164 rs574652148 rs369484186 rs182549235 rs17227996 rs13380059 rs61734298 rs3784588 rs3784587 rs12898290 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1 {ECO:0000269|PubMed:16572171}; IsoId=Q7Z4N2-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=2 {ECO:0000269|PubMed:9806836, ECO:0000269|Ref.3}; IsoId=Q7Z4N2-2; Sequence=VSP_052748; Name=3 {ECO:0000269|Ref.3}; IsoId=Q7Z4N2-3; Sequence=VSP_052749; Name=4 {ECO:0000269|Ref.3}; IsoId=Q7Z4N2-4; Sequence=VSP_052750; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q7Z4N2-5; Sequence=VSP_046786; Name=6; IsoId=Q7Z4N2-6; Sequence=VSP_046787; Name=7; IsoId=Q7Z4N2-7; Sequence=VSP_046788, VSP_046789; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:11535825}.


uniprotID: Q9HCF6
geneSymbol: TRPM3
reactome: R-HSA-3295583;
length: 1732
go: ENSG00000083067;
snps: rs13440436 rs6560142 rs41287373 rs17535963
name:
Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC-3) (LTrpC3) (Melastatin-2) (MLSN2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; cation channel activity [GO:0005261]; calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; detection of temperature stimulus [GO:0016048]; protein tetramerization [GO:0051262]; sensory perception of temperature stimulus [GO:0050951]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=11;  Name=1; Synonyms=TRPM3f; IsoId=Q9HCF6-1; Sequence=Displayed; Name=2; Synonyms=TRPM3a; IsoId=Q9HCF6-2; Sequence=VSP_012826; Name=3; Synonyms=TRPM3b; IsoId=Q9HCF6-3; Sequence=VSP_012826, VSP_012828; Name=4; Synonyms=TRPM3d; IsoId=Q9HCF6-4; Sequence=VSP_012826, VSP_012829; Name=5; Synonyms=TRPM3e; IsoId=Q9HCF6-5; Sequence=VSP_012826, VSP_012828, VSP_012829; Name=6; Synonyms=TRPM3c; IsoId=Q9HCF6-6; Sequence=VSP_012826, VSP_012830; Name=7; IsoId=Q9HCF6-7; Sequence=VSP_012829; Name=8; IsoId=Q9HCF6-8; Sequence=VSP_012826, VSP_012827, VSP_012829; Name=10; IsoId=Q9HCF6-10; Sequence=VSP_012826, VSP_012831, VSP_012832; Name=11; IsoId=Q9HCF6-11; Sequence=VSP_039107; Name=12; IsoId=Q9HCF6-12; Sequence=VSP_043515, VSP_012826, VSP_043516; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12672827}; Multi-pass membrane protein {ECO:0000269|PubMed:12672827}.


uniprotID: Q8TD43
geneSymbol: TRPM4
reactome: R-HSA-3295583;
pdb: 5WP6;6BQR;6BQV;
length: 1214
go: ENSG00000130529;
name:
Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; sodium channel complex [GO:0034706]; spanning component of membrane [GO:0089717]; spanning component of plasma membrane [GO:0044214]; ATP binding [GO:0005524]; calcium activated cation channel activity [GO:0005227]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; sodium channel activity [GO:0005272]; adaptive immune response [GO:0002250]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling [GO:0019722]; cellular response to ATP [GO:0071318]; dendritic cell chemotaxis [GO:0002407]; inorganic cation transmembrane transport [GO:0098662]; membrane depolarization during AV node cell action potential [GO:0086045]; membrane depolarization during bundle of His cell action potential [GO:0086048]; membrane depolarization during Purkinje myocyte cell action potential [GO:0086047]; negative regulation of bone mineralization [GO:0030502]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of atrial cardiac muscle cell action potential [GO:1903949]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of heart rate [GO:0010460]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of regulation of vascular smooth muscle cell membrane depolarization [GO:1904199]; positive regulation of vasoconstriction [GO:0045907]; protein homotetramerization [GO:0051289]; protein sumoylation [GO:0016925]; regulation of heart rate by cardiac conduction [GO:0086091]; regulation of T cell cytokine production [GO:0002724]; regulation of ventricular cardiac muscle cell action potential [GO:0098911]; sodium ion import across plasma membrane [GO:0098719]; vasoconstriction [GO:0042310]

snps:
rs267607142 rs113984787 rs144781529 rs172146854 rs387907216 rs146564314 rs172147855 rs201907325 rs56355369 rs172149856 rs172150857 rs200038418 rs172155862 rs172151858 rs172152859 rs150391806 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TRPM4b; IsoId=Q8TD43-1; Sequence=Displayed; Name=2; Synonyms=TRPM4a; IsoId=Q8TD43-2; Sequence=VSP_021442; Name=3; Synonyms=TRPM4c; IsoId=Q8TD43-3; Sequence=VSP_021443; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:12015988, ECO:0000269|PubMed:15331675, ECO:0000269|PubMed:15590641, ECO:0000269|PubMed:19945433, ECO:0000269|PubMed:29211723}; Multi-pass membrane protein {ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581}. Endoplasmic reticulum {ECO:0000269|PubMed:19945433}. Golgi apparatus {ECO:0000269|PubMed:19945433}.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000269|PubMed:11535825}. Endoplasmic reticulum. Golgi apparatus.


uniprotID: Q9BX84
geneSymbol: TRPM6
reactome: R-HSA-3295583;
length: 2022
go: ENSG00000119121;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23942199}; Multi-pass membrane protein.
name:
Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; calcium ion transmembrane transport [GO:0070588]; protein tetramerization [GO:0051262]; response to toxic substance [GO:0009636]

snps:
rs1193127627 rs121912625 rs56155062 rs13290391 rs2274922 rs55694430 rs34608911 rs3750425 rs2274924 rs55679040 rs56254742 rs56290308 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=TRPM6a; IsoId=Q9BX84-1; Sequence=Displayed; Name=TRPM6b; IsoId=Q9BX84-2; Sequence=VSP_012069; Name=TRPM6c; IsoId=Q9BX84-3; Sequence=VSP_012070; Name=TRPM6t; IsoId=Q9BX84-4; Sequence=VSP_012075, VSP_012076; Name=M6-kinase 1; IsoId=Q9BX84-5; Sequence=VSP_012074; Note=Lacks the ion channel region.; Name=M6-kinase 2; IsoId=Q9BX84-6; Sequence=VSP_012073; Note=Lacks the ion channel region.; Name=M6-kinase 3; IsoId=Q9BX84-7; Sequence=VSP_012071, VSP_012072; Note=Lacks the ion channel region.; 


uniprotID: Q96QT4
geneSymbol: TRPM7
reactome: R-HSA-3295583;
length: 1865
go: ENSG00000092439;
drug: DB04395;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Channel-kinase 1) (Long transient receptor potential channel 7) (LTrpC-7) (LTrpC7)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; actin binding [GO:0003779]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; metal ion binding [GO:0046872]; myosin binding [GO:0017022]; protein serine/threonine kinase activity [GO:0004674]; actomyosin structure organization [GO:0031032]; calcium ion transmembrane transport [GO:0070588]; calcium-dependent cell-matrix adhesion [GO:0016340]; cellular magnesium ion homeostasis [GO:0010961]; necroptotic process [GO:0070266]; protein autophosphorylation [GO:0046777]; protein tetramerization [GO:0051262]

snps:
rs56064201 rs55924090 rs56040619 rs1040254222 rs55681028 rs34530969 rs56298128 rs34711809 rs56090496 rs56288221 rs55970334 rs55840070 rs8042919 


uniprotID: Q7Z2W7
geneSymbol: TRPM8
reactome: R-HSA-3295583;
length: 1104
go: ENSG00000144481;
drug: DB00825;
snps: rs13004520 rs17868387 rs7593557 rs28902173 rs17862932 rs28902201
name:
Transient receptor potential cation channel subfamily M member 8 (Long transient receptor potential channel 6) (LTrpC-6) (LTrpC6) (Transient receptor potential p8) (Trp-p8)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; protein homodimerization activity [GO:0042803]; calcium ion transmembrane transport [GO:0070588]; cellular calcium ion homeostasis [GO:0006874]; detection of temperature stimulus [GO:0016048]; positive regulation of cold-induced thermogenesis [GO:0120162]; protein homotetramerization [GO:0051289]; protein homotrimerization [GO:0070207]; response to cold [GO:0009409]; thermoception [GO:0050955]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q7Z2W7-1; Sequence=Displayed; Name=2; Synonyms=sTRPM8-18, sM8-18; IsoId=Q7Z2W7-2; Sequence=VSP_053268, VSP_012332, VSP_012333; Name=3; Synonyms=sTRPM8-6, sM8-6; IsoId=Q7Z2W7-3; Sequence=VSP_012330, VSP_012332, VSP_012333; Name=4; IsoId=Q7Z2W7-4; Sequence=VSP_054505, VSP_054506, VSP_054507; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.


uniprotID: Q9Y5S1
geneSymbol: TRPV2
reactome: R-HSA-3295583;
pdb: 2F37;
length: 764
go: ENSG00000187688;
snps: rs3813768 rs8071215
name:
Transient receptor potential cation channel subfamily V member 2 (TrpV2) (Osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1)

sequence:

opentargets:
axonal growth cone [GO:0044295]; cell body [GO:0044297]; cell surface [GO:0009986]; growth cone membrane [GO:0032584]; integral component of plasma membrane [GO:0005887]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; cation channel activity [GO:0005261]; ion channel activity [GO:0005216]; ion transmembrane transporter activity [GO:0015075]; calcium ion transmembrane transport [GO:0070588]; positive regulation of axon extension [GO:0045773]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cold-induced thermogenesis [GO:0120162]; response to heat [GO:0009408]; response to temperature stimulus [GO:0009266]; sensory perception [GO:0007600]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.


uniprotID: Q9Y606
geneSymbol: PUS1
reactome: R-HSA-6782315;R-HSA-6787450;
pdb: 4IQM;4ITS;4J37;4NZ6;4NZ7;
length: 427
go: ENSG00000177192;
snps: rs76655496 rs104894371
name:
tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; steroid receptor RNA activator RNA binding [GO:0002153]; tRNA binding [GO:0000049]; tRNA pseudouridine synthase activity [GO:0106029]; mitochondrial tRNA pseudouridine synthesis [GO:0070902]; mRNA pseudouridine synthesis [GO:1990481]; tRNA pseudouridine synthesis [GO:0031119]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y606-1; Sequence=Displayed; Name=2; IsoId=Q9Y606-2; Sequence=VSP_020116; 

location:
SUBCELLULAR LOCATION: Isoform 1: Mitochondrion {ECO:0000269|PubMed:17056637}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:17056637}.


uniprotID: Q2T9K0
geneSymbol: TMEM44
name: Transmembrane protein 44
length: 475
go: ENSG00000145014;
opentargets: integral component of membrane [GO:0016021]
snps: rs1675955 rs12695036 rs922282
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q2T9K0-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q2T9K0-2; Sequence=VSP_024565; Note=No experimental confirmation available.; Name=3; IsoId=Q2T9K0-4; Sequence=VSP_024565, VSP_024569, VSP_024571; Note=No experimental confirmation available.; Name=4; IsoId=Q2T9K0-6; Sequence=VSP_024565, VSP_039211; Note=No experimental confirmation available.; Name=5; IsoId=Q2T9K0-7; Sequence=VSP_024565, VSP_046357; Note=No experimental confirmation available.; 


uniprotID: Q68CL5
geneSymbol: TPGS2
reactome: R-HSA-8955332;
name: Tubulin polyglutamylase complex subunit 2 (PGs2)
length: 300
go: ENSG00000134779;
opentargets: cytoplasm [GO:0005737]; microtubule [GO:0005874]; protein polyglutamylation [GO:0018095]
snps: rs2303507
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=2; IsoId=Q68CL5-2; Sequence=Displayed; Name=1; IsoId=Q68CL5-1; Sequence=VSP_020113; Name=3; IsoId=Q68CL5-3; Sequence=VSP_014884, VSP_014885; Name=4; IsoId=Q68CL5-4; Sequence=VSP_054525; Note=No experimental confirmation available.; Name=5; IsoId=Q68CL5-5; Sequence=VSP_055634; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: P0DI82
geneSymbol: TRAPPC2B
name: Trafficking protein particle complex subunit 2B (MBP-1-interacting protein 2A) (MIP-2A)
length: 140
go: ENSG00000196459;ENSG00000256060;
sequence:
MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ER to Golgi vesicle-mediated transport [GO:0006888]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11134351}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm {ECO:0000250|UniProtKB:P0DI81}. Note=Localized in perinuclear granular structures. {ECO:0000250|UniProtKB:P0DI81}.


uniprotID: Q8N609
geneSymbol: TRAM1L1
name: Translocating chain-associated membrane protein 1-like 1
length: 369
go: ENSG00000174599;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; rough endoplasmic reticulum [GO:0005791]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]


uniprotID: Q9ULW0
geneSymbol: TPX2
reactome: R-HSA-6804756;R-HSA-8854518;
pdb: 1OL5;3E5A;3HA6;4C3P;5LXM;6BJC;
length: 747
go: ENSG00000088325;
name:
Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)

sequence:

opentargets:
axon hillock [GO:0043203]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; importin-alpha family protein binding [GO:0061676]; protein kinase binding [GO:0019901]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cell proliferation [GO:0008283]; mitotic cell cycle [GO:0000278]; mitotic spindle assembly [GO:0090307]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of mitotic spindle organization [GO:0060236]; regulation of signal transduction by p53 class mediator [GO:1901796]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULW0-1; Sequence=Displayed; Name=2; Synonyms=HCA90; IsoId=Q9ULW0-2; Sequence=VSP_057355; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18663142, ECO:0000269|PubMed:19208764}. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. {ECO:0000269|PubMed:19208764}.


uniprotID: O15016
geneSymbol: TRIM66
name: Tripartite motif-containing protein 66
length: 1216
go: ENSG00000166436;
sequence:

opentargets:
aggresome [GO:0016235]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; zinc ion binding [GO:0008270]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15016-1; Sequence=Displayed; Name=2; IsoId=O15016-2; Sequence=VSP_038386; 

location:
SUBCELLULAR LOCATION: Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.


uniprotID: Q8N7C3
geneSymbol: TRIML2
length: 387
name:
Probable E3 ubiquitin-protein ligase TRIML2 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIML2) (SPRY domain-containing protein 6) (Tripartite motif family-like protein 2)

sequence:

opentargets:
transferase activity [GO:0016740]; protein ubiquitination [GO:0016567]; response to retinoic acid [GO:0032526]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N7C3-1; Sequence=Displayed; Name=2; IsoId=Q8N7C3-2; Sequence=VSP_055446, VSP_055447, VSP_055448; Note=No experimental confirmation available.; 


uniprotID: P34981
geneSymbol: TRHR
reactome: R-HSA-375276;R-HSA-416476;
name: Thyrotropin-releasing hormone receptor (TRH-R) (Thyroliberin receptor)
length: 398
go: ENSG00000174417;
drug: DB09421;
snps: rs5774 rs13306060
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; thyrotropin-releasing hormone receptor activity [GO:0004997]; G protein-coupled receptor signaling pathway [GO:0007186]


uniprotID: Q86UV6
geneSymbol: TRIM74
name: Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C)
length: 250
go: ENSG00000155428;
opentargets: cytosol [GO:0005829]; zinc ion binding [GO:0008270]
snps: rs121966
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86UV6-1; Sequence=Displayed; Name=2; IsoId=Q86UV6-2; Sequence=VSP_032087; Note=No experimental confirmation available.; 


uniprotID: Q6UXN2
geneSymbol: TREML4
reactome: R-HSA-198933;
length: 200
go: ENSG00000188056;
snps: rs9369265 rs9471515 rs7769759
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24975946}.
name:
Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 4)

sequence:

opentargets:
extracellular region [GO:0005576]; plasma membrane [GO:0005886]; innate immune response [GO:0045087]; positive regulation of toll-like receptor 7 signaling pathway [GO:0034157]; regulation of immune response [GO:0050776]


uniprotID: O15050
geneSymbol: TRANK1
name: TPR and ankyrin repeat-containing protein 1 (Lupus brain antigen 1 homolog)
length: 2925
go: ENSG00000168016;
snps: rs17201603 rs17201603 rs11712950
sequence:


uniprotID: P48995
geneSymbol: TRPC1
reactome: R-HSA-3295583;R-HSA-418890;R-HSA-5578775;R-HSA-983695;
name: Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)
length: 793
go: ENSG00000144935;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
cation channel complex [GO:0034703]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium channel activity [GO:0005262]; cation channel activity [GO:0005261]; inositol 1,4,5 trisphosphate binding [GO:0070679]; ion channel binding [GO:0044325]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; manganese ion transport [GO:0006828]; melanin biosynthetic process [GO:0042438]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; regulation of cardiac conduction [GO:1903779]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to calcium ion [GO:0051592]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=P48995-1; Sequence=Displayed; Name=Short; IsoId=P48995-2; Sequence=VSP_006560; 


uniprotID: Q13507
geneSymbol: TRPC3
reactome: R-HSA-114508;R-HSA-139853;R-HSA-3295583;R-HSA-418890;
pdb: 5ZBG;6CUD;6D7L;6DJS;
length: 836
go: ENSG00000138741;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (TRP-3) (hTrp-3) (hTrp3)

sequence:

opentargets:
cation channel complex [GO:0034703]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; manganese ion transport [GO:0006828]; phototransduction [GO:0007602]; platelet activation [GO:0030168]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cardiac muscle hypertrophy in response to stress [GO:1903244]; regulation of cytosolic calcium ion concentration [GO:0051480]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; single fertilization [GO:0007338]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13507-1; Sequence=Displayed; Name=2; IsoId=Q13507-2; Sequence=VSP_042446; Name=3; IsoId=Q13507-3; Sequence=VSP_042445; 


uniprotID: Q86UB9
geneSymbol: TMEM135
name: Transmembrane protein 135 (Peroxisomal membrane protein 52) (PMP52)
length: 458
go: ENSG00000166575;
snps: rs17854687 rs2276102 rs11235097
sequence:

opentargets:
integral component of membrane [GO:0016021]; lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; peroxisome organization [GO:0007031]; regulation of mitochondrial fission [GO:0090140]; response to cold [GO:0009409]; response to food [GO:0032094]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86UB9-1; Sequence=Displayed; Name=2; IsoId=Q86UB9-2; Sequence=VSP_024579; 

location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9CYV5}. Peroxisome membrane {ECO:0000250|UniProtKB:Q9CYV5}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q6ZMR5
geneSymbol: TMPRSS11A
length: 421
snps: rs353163
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
name:
Transmembrane protease serine 11A (EC 3.4.21.-) (Airway trypsin-like protease 1) (Epidermal type-II transmembrane serine protease) (Esophageal cancer-susceptibility gene 1 protein)

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; serine-type endopeptidase activity [GO:0004252]; cell cycle [GO:0007049]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZMR5-1; Sequence=Displayed; Name=2; IsoId=Q6ZMR5-2; Sequence=VSP_027610; 


uniprotID: Q8NDV7
geneSymbol: TNRC6A
pdb: 5W6V;
length: 1962
go: ENSG00000090905;
snps: rs11639856 rs6497759 rs3803716 rs2112782
reactome:
R-HSA-1912408;R-HSA-2559580;R-HSA-2559585;R-HSA-4086398;R-HSA-426496;R-HSA-5578749;R-HSA-5628897;R-HSA-5687128;R-HSA-8934593;R-HSA-8936459;R-HSA-8943723;R-HSA-8948700;R-HSA-9018519;

name:
Trinucleotide repeat-containing gene 6A protein (CAG repeat protein 26) (EMSY interactor protein) (GW182 autoantigen) (Protein GW1) (Glycine-tryptophan protein of 182 kDa)

sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; micro-ribonucleoprotein complex [GO:0035068]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RNA binding [GO:0003723]; cellular response to starvation [GO:0009267]; gene silencing by miRNA [GO:0035195]; miRNA mediated inhibition of translation [GO:0035278]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; posttranscriptional gene silencing by RNA [GO:0035194]; regulation of gene silencing by miRNA [GO:0060964]; regulation of megakaryocyte differentiation [GO:0045652]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=TNGW1; IsoId=Q8NDV7-1; Sequence=Displayed; Name=2; IsoId=Q8NDV7-2; Sequence=VSP_013294; Name=3; IsoId=Q8NDV7-3; Sequence=VSP_037287, VSP_037288, VSP_037289; Name=4; IsoId=Q8NDV7-4; Sequence=VSP_013292; Name=5; IsoId=Q8NDV7-5; Sequence=VSP_013295; Note=No experimental confirmation available.; Name=6; IsoId=Q8NDV7-6; Sequence=VSP_037288; 

location:
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:11950943, ECO:0000269|PubMed:13130130, ECO:0000269|PubMed:15494374, ECO:0000269|PubMed:15908945, ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:18946079, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19324964}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}.


uniprotID: P60174
geneSymbol: TPI1
reactome: R-HSA-70171;R-HSA-70263;
pdb: 1HTI;1KLG;1KLU;1WYI;2IAM;2IAN;2JK2;2VOM;4BR1;4E41;4POC;4POD;4UNK;4UNL;4ZVJ;6C2G;6D43;
name: Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Triose-phosphate isomerase)
length: 286
go: ENSG00000111669;
drug: DB03379;DB03900;DB02726;DB03132;DB07387;DB04510;DB03135;DB03314;DB01695;DB03026;
snps: rs121964848 rs121964845 rs121964846 rs188138723 rs121964849 rs121964847
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nucleus [GO:0005634]; triose-phosphate isomerase activity [GO:0004807]; ubiquitin protein ligase binding [GO:0031625]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; glyceraldehyde-3-phosphate biosynthetic process [GO:0046166]; glycerol catabolic process [GO:0019563]; glycolytic process [GO:0006096]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=3;  Name=1; IsoId=P60174-3; Sequence=Displayed; Name=2; IsoId=P60174-1; Sequence=VSP_041895; Name=4; IsoId=P60174-4; Sequence=VSP_045310; Note=Produced by alternative splicing.; 


uniprotID: Q96KB5
geneSymbol: PBK
pdb: 5J0A;
length: 322
go: ENSG00000168078;
snps: rs3779620 rs17057901 rs36086402
name:
Lymphokine-activated killer T-cell-originated protein kinase (EC 2.7.12.2) (Cancer/testis antigen 84) (CT84) (MAPKK-like protein kinase) (Nori-3) (PDZ-binding kinase) (Spermatogenesis-related protein kinase) (SPK) (T-LAK cell-originated protein kinase)

sequence:

opentargets:
nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; cellular response to UV [GO:0034644]; mitotic cell cycle [GO:0000278]; negative regulation of inflammatory response [GO:0050728]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of stress-activated MAPK cascade [GO:0032873]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96KB5-1; Sequence=Displayed; Name=2; IsoId=Q96KB5-2; Sequence=VSP_055269; Note=No experimental confirmation available.; 


uniprotID: Q17RH7
geneSymbol: TPRXL
name: Putative protein TPRXL
length: 258
opentargets: DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]
sequence:


uniprotID: P62995
geneSymbol: TRA2B
reactome: R-HSA-72163;
pdb: 2CQC;2KXN;2RRA;2RRB;
length: 288
go: ENSG00000136527;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9212162, ECO:0000269|PubMed:9546399}.
name:
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)

sequence:

opentargets:
nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; pre-mRNA binding [GO:0036002]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; cellular response to glucose stimulus [GO:0071333]; cerebral cortex regionalization [GO:0021796]; embryonic brain development [GO:1990403]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; protein complex oligomerization [GO:0051259]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing, via transesterification reactions [GO:0000375]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=HTRA2-beta1; IsoId=P62995-1, Q15815-1; Sequence=Displayed; Name=2; Synonyms=HTRA2-beta2; IsoId=P62995-2, Q15815-2; Sequence=VSP_005898, VSP_005899; Name=3; Synonyms=HTRA2-beta3; IsoId=P62995-3, Q15815-3; Sequence=VSP_005896; 


uniprotID: Q6F5E7
geneSymbol: TXNRD3NB
length: 133
go: ENSG00000206483;ENSG00000283374;
name:
Protein TXNRD3NB (Thioredoxin reductase 2 intronic transcript 1) (Thioredoxin reductase 3 intronic transcript 1) (Thioredoxin reductase 3 neighbor gene protein) (TXNRD3 neighbor gene protein) (Thioredoxin reductase 3 new transcript 1)

sequence:
MRDLSERRLGQPELKAEQQMPLEPVRARLSVGLACCCSHTTAEASSLEHGDKVFGQGFPSPLEEIKRLLKISRALQARSVPSTQEKAKCLSGEPGQPEGKGQETYPGPGKVEGKAEPAMRKDDVCPGMKCISG


uniprotID: Q9UPV9
geneSymbol: TRAK1
reactome: R-HSA-6802952;
length: 953
go: ENSG00000182606;
name:
Trafficking kinesin-binding protein 1 (106 kDa O-GlcNAc transferase-interacting protein) (Protein Milton)

sequence:

opentargets:
axon cytoplasm [GO:1904115]; axonal growth cone [GO:0044295]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; dendrite [GO:0030425]; dendrite cytoplasm [GO:0032839]; early endosome [GO:0005769]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; GABA receptor binding [GO:0050811]; myosin binding [GO:0017022]; signaling receptor binding [GO:0005102]; TPR domain binding [GO:0030911]; anterograde axonal transport [GO:0008089]; anterograde axonal transport of mitochondrion [GO:0098957]; dendrite morphogenesis [GO:0048813]; endosome to lysosome transport [GO:0008333]; mitochondrion distribution [GO:0048311]; neurogenesis [GO:0022008]; positive regulation of axonogenesis [GO:0050772]; protein localization [GO:0008104]; protein O-linked glycosylation [GO:0006493]; protein targeting [GO:0006605]; regulation of transcription by RNA polymerase II [GO:0006357]; vesicle transport along microtubule [GO:0047496]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Milton1 {ECO:0000303|PubMed:24995978}; IsoId=Q9UPV9-1; Sequence=Displayed; Name=2; IsoId=Q9UPV9-2; Sequence=VSP_010839, VSP_010840, VSP_010841; Name=3; IsoId=Q9UPV9-3; Sequence=VSP_045558, VSP_045559, VSP_045560; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18986759}. Nucleus {ECO:0000269|PubMed:12435728}. Mitochondrion {ECO:0000269|PubMed:15644324, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}. Early endosome {ECO:0000269|PubMed:18675823}. Endosome {ECO:0000269|PubMed:18675823}. Mitochondrion membrane {ECO:0000269|PubMed:24995978}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q6PD31}. Note=Predominantly associated with early endosome. The localization to early endosomes depends on its interaction with HGS/HRS (PubMed:18675823). Colocalizes with MGARP at the mitochondria (PubMed:19528298). {ECO:0000269|PubMed:18675823, ECO:0000269|PubMed:19528298}.


uniprotID: O15533
geneSymbol: TAPBP
reactome: R-HSA-1236974;R-HSA-983170;
pdb: 3F8U;6ENY;
name: Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein)
length: 448
snps: rs2071888
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi membrane [GO:0000139]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; integral component of membrane [GO:0016021]; MHC class I peptide loading complex [GO:0042824]; phagocytic vesicle membrane [GO:0030670]; MHC class I protein binding [GO:0042288]; peptide antigen binding [GO:0042605]; peptide antigen-transporting ATPase activity [GO:0015433]; TAP complex binding [GO:0062061]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; unfolded protein binding [GO:0051082]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; immune response [GO:0006955]; peptide antigen stabilization [GO:0050823]; protein-containing complex assembly [GO:0065003]; regulation of gene expression [GO:0010468]; regulation of protein complex stability [GO:0061635]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane [GO:1990668]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O15533-1; Sequence=Displayed; Name=2; IsoId=O15533-2; Sequence=VSP_002577; Note=Due to a partial intron retention.; Name=3; IsoId=O15533-3; Sequence=VSP_017055; Note=No experimental confirmation available.; Name=4; Synonyms=tpsnDeltaEx3; IsoId=O15533-4; Sequence=VSP_044455; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.


uniprotID: Q9Y4K3
geneSymbol: TRAF6
pdb: 1LB4;1LB5;1LB6;2ECI;2JMD;3HCS;3HCT;3HCU;4Z8M;
length: 522
go: ENSG00000175104;
reactome:
R-HSA-1257604;R-HSA-166058;R-HSA-168638;R-HSA-168927;R-HSA-193692;R-HSA-202424;R-HSA-205043;R-HSA-209543;R-HSA-209560;R-HSA-2871837;R-HSA-445989;R-HSA-450302;R-HSA-450321;R-HSA-5607764;R-HSA-5689880;R-HSA-5689896;R-HSA-6811558;R-HSA-9014325;R-HSA-9020702;R-HSA-933541;R-HSA-933542;R-HSA-937039;R-HSA-937041;R-HSA-937042;R-HSA-937072;R-HSA-975110;R-HSA-975138;R-HSA-975144;R-HSA-975155;R-HSA-975163;R-HSA-975871;

name:
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)

sequence:

opentargets:
CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase B binding [GO:0043422]; protein kinase binding [GO:0019901]; protein N-terminus binding [GO:0047485]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; activation of MAPK activity [GO:0000187]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; activation of protein kinase activity [GO:0032147]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; bone resorption [GO:0045453]; cell development [GO:0048468]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to lipopolysaccharide [GO:0071222]; Fc-epsilon receptor signaling pathway [GO:0038095]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; membrane protein intracellular domain proteolysis [GO:0031293]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; neural tube closure [GO:0001843]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; odontogenesis of dentin-containing tooth [GO:0042475]; ossification [GO:0001503]; osteoclast differentiation [GO:0030316]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of lipopolysaccharide-mediated signaling pathway [GO:0031666]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of osteoclast differentiation [GO:0045672]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell proliferation [GO:0042102]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; protein autoubiquitination [GO:0051865]; protein deubiquitination [GO:0016579]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of immunoglobulin secretion [GO:0051023]; response to interleukin-1 [GO:0070555]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18093978}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18093978}. Nucleus {ECO:0000269|PubMed:18093978}. Lipid droplet {ECO:0000250|UniProtKB:P70196}. Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.


uniprotID: Q9BQ61
geneSymbol: TRIR
name: Telomerase RNA component interacting RNase (EC 3.1.13.-) (Exoribonuclease TRIR)
length: 176
go: ENSG00000123144;
sequence:
MAARGRRAEPQGREAPGPAGGGGGGSRWAESGSGTSPESGDEEVSGAGSSPVSGGVNLFANDGSFLELFKRKMEEEQRQRQEEPPPGPQRPDQSAAAAGPGDPKRKGGPGSTLSFVGKRRGGNKLALKTGIVAKKQKTEDEVLTSKGDAWAKYMAEVKKYKAHQCGDDDKTRPLVK

opentargets:
3'-5' exonuclease activity [GO:0008408]; 5'-3' exonuclease activity [GO:0008409]; RNA binding [GO:0003723]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; rRNA catabolic process [GO:0016075]


uniprotID: Q6NT89
geneSymbol: TRNP1
name: TMF-regulated nuclear protein 1
length: 227
go: ENSG00000253368;
snps: rs6689941
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nuclear euchromatin [GO:0005719]; nucleus [GO:0005634]; DNA binding [GO:0003677]; cell cycle [GO:0007049]; cerebellar cortex morphogenesis [GO:0021696]; neural precursor cell proliferation [GO:0061351]; regulation of cell cycle [GO:0051726]; regulation of cell proliferation [GO:0042127]


uniprotID: Q86TN4
geneSymbol: TRPT1
name: tRNA 2'-phosphotransferase 1 (EC 2.7.1.160)
length: 253
go: ENSG00000149743;
snps: rs12788168 rs1059440 rs11549690
sequence:

opentargets:
tRNA 2'-phosphotransferase activity [GO:0000215]; regulation of protein kinase activity [GO:0045859]; tRNA splicing, via endonucleolytic cleavage and ligation [GO:0006388]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86TN4-1; Sequence=Displayed; Name=2; IsoId=Q86TN4-2; Sequence=VSP_022524; Note=No experimental confirmation available.; Name=3; IsoId=Q86TN4-3; Sequence=VSP_045273; Note=No experimental confirmation available.; Name=4; IsoId=Q86TN4-4; Sequence=VSP_045827; Note=No experimental confirmation available.; 


uniprotID: Q9H1K6
geneSymbol: TLNRD1
name: Talin rod domain-containing protein 1 (Mesoderm development candidate 1)
length: 362
go: ENSG00000140406;
opentargets: stress fiber [GO:0001725]; actin binding [GO:0003779]
sequence:


uniprotID: Q8N4H5
geneSymbol: TOMM5
reactome: R-HSA-1268020;R-HSA-5205685;
name: Mitochondrial import receptor subunit TOM5 homolog
sequence: MFRIEGLAPKLDPEEMKRKMREDVISSIRNFLIYVALLRVTPFILKKLDSI
length: 51
go: ENSG00000175768;
opentargets:
integral component of membrane [GO:0016021]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein targeting to mitochondrion [GO:0006626]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N4H5-1; Sequence=Displayed; Name=2; IsoId=Q8N4H5-2; Sequence=VSP_046982; Note=No experimental confirmation available.; Name=3; IsoId=Q8N4H5-3; Sequence=VSP_046983; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}; Single-pass membrane protein {ECO:0000269|PubMed:18331822}.


uniprotID: P48553
geneSymbol: TRAPPC10
reactome: R-HSA-204005;R-HSA-8876198;
length: 1259
go: ENSG00000160218;
snps: rs915877 rs2071152
location: SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
name:
Trafficking protein particle complex subunit 10 (Epilepsy holoprosencephaly candidate 1 protein) (EHOC-1) (Protein GT334) (Trafficking protein particle complex subunit TMEM1) (Transport protein particle subunit TMEM1) (TRAPP subunit TMEM1)

sequence:

opentargets:
cytosol [GO:0005829]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; TRAPPII protein complex [GO:1990071]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; COPII vesicle coating [GO:0048208]; early endosome to Golgi transport [GO:0034498]; intra-Golgi vesicle-mediated transport [GO:0006891]; protein complex oligomerization [GO:0051259]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48553-1; Sequence=Displayed; Name=2; IsoId=P48553-2; Sequence=VSP_056589, VSP_056590; Note=No experimental confirmation available.; 


uniprotID: A6NDI0
geneSymbol: TRIM49B
name: Putative tripartite motif-containing protein 49B (RING finger protein 18B)
length: 452
go: ENSG00000182053;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
snps: rs2696914
sequence:


uniprotID: Q6ZNB5
name: Putative short transient receptor potential channel 2-like protein (TrpC2-like protein)
length: 142
go: ENSG00000254469;
sequence:
MAPVKISHVVSFSSQDPKYPVENLLNPDSPRRPWLGCPQDKSGQLKVELQLERAVPTGYIDVGNCGCAFLQIDVGHSSWPLDRPFITLLPATTLMSLTDSKQGKNRSGVRMFKDGKEGKSRKDGGGLYEKQRCSTKEDCECY

opentargets:
nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; base-excision repair [GO:0006284]; single strand break repair [GO:0000012]


uniprotID: Q6P9F5
geneSymbol: TRIM40
name: Tripartite motif-containing protein 40 (Probable E3 NEDD8-protein ligase) (RING finger protein 35)
length: 258
go: ENSG00000204614;
snps: rs12528473 rs757259 rs757259
sequence:

opentargets:
IkappaB kinase complex [GO:0008385]; zinc ion binding [GO:0008270]; negative regulation of cell growth [GO:0030308]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of protein localization to nucleus [GO:1900181]; protein neddylation [GO:0045116]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P9F5-1; Sequence=Displayed; Name=2; IsoId=Q6P9F5-2; Sequence=VSP_012131; Note=No experimental confirmation available.; 


uniprotID: Q9Y577
geneSymbol: TRIM17
reactome: R-HSA-877300;
length: 477
go: ENSG00000162931;
name:
E3 ubiquitin-protein ligase TRIM17 (EC 2.3.2.27) (RING finger protein 16) (RING-type E3 ubiquitin transferase TRIM17) (Testis RING finger protein) (Tripartite motif-containing protein 17)

sequence:

opentargets:
intracellular [GO:0005622]; protein binding, bridging [GO:0030674]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; protein autoubiquitination [GO:0051865]; regulation of protein localization [GO:0032880]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y577-1; Sequence=Displayed; Name=2; IsoId=Q9Y577-2; Sequence=VSP_040994, VSP_040995; 


uniprotID: Q9BVG3
geneSymbol: TRIM62
reactome: R-HSA-877300;
length: 475
go: ENSG00000116525;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23402750}.
name:
E3 ubiquitin-protein ligase TRIM62 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM62) (Tripartite motif-containing protein 62)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of viral transcription [GO:0032897]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of viral entry into host cell [GO:0046596]; regulation of viral release from host cell [GO:1902186]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BVG3-1; Sequence=Displayed; Name=2; IsoId=Q9BVG3-2; Sequence=VSP_055441, VSP_055442; Note=No experimental confirmation available.; 


uniprotID: Q9BZR9
geneSymbol: TRIM8
reactome: R-HSA-877300;
length: 551
go: ENSG00000171206;
name:
E3 ubiquitin-protein ligase TRIM8 (EC 2.3.2.27) (Glioblastoma-expressed RING finger protein) (RING finger protein 27) (RING-type E3 ubiquitin transferase TRIM8) (Tripartite motif-containing protein 8)

sequence:

opentargets:
cytosol [GO:0005829]; PML body [GO:0016605]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein localization to nucleus [GO:1900182]; protein ubiquitination [GO:0016567]; stem cell population maintenance [GO:0019827]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23152791}. Nucleus {ECO:0000269|PubMed:23152791}. Note=Nucleo-cytoplasmic translocation is involved in regulation of NF-kappa-B. {ECO:0000269|PubMed:23152791}.


uniprotID: Q13061
geneSymbol: TRDN
reactome: R-HSA-2672351;R-HSA-5578775;
name: Triadin
length: 729
go: ENSG00000186439;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; junctional membrane complex [GO:0030314]; junctional sarcoplasmic reticulum membrane [GO:0014701]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; ion channel binding [GO:0044325]; protein binding, bridging [GO:0030674]; signaling receptor binding [GO:0005102]; cellular calcium ion homeostasis [GO:0006874]; cytoplasmic microtubule organization [GO:0031122]; endoplasmic reticulum membrane organization [GO:0090158]; heart contraction [GO:0060047]; ion transmembrane transport [GO:0034220]; muscle contraction [GO:0006936]; negative regulation of ryanodine-sensitive calcium-release channel activity [GO:0060315]; positive regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901846]; positive regulation of ryanodine-sensitive calcium-release channel activity [GO:0060316]; regulation of cardiac conduction [GO:1903779]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of cell communication by electrical coupling [GO:0010649]; regulation of release of sequestered calcium ion into cytosol [GO:0051279]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0014808]; response to bacterium [GO:0009617]

snps:
rs397515459 rs9490809 rs6902416 rs35766971 rs6901953 rs28494009 rs17737379 rs2873479 rs6569336 rs7771303 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13061-1; Sequence=Displayed; Name=2; IsoId=Q13061-2; Sequence=VSP_045563, VSP_045564, VSP_045565; Note=No experimental confirmation available.; Name=3; IsoId=Q13061-3; Sequence=VSP_045561, VSP_045562; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22422768}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}; Single-pass type II membrane protein {ECO:0000269|PubMed:22422768, ECO:0000269|PubMed:24325401}.


uniprotID: Q8IYM9
geneSymbol: TRIM22
reactome: R-HSA-877300;
length: 498
go: ENSG00000132274;
snps: rs7935564 rs2291843 rs1063303 rs12364019
name:
E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22)

sequence:

opentargets:
Cajal body [GO:0015030]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; protein binding, bridging [GO:0030674]; protein kinase binding [GO:0019901]; transcription corepressor activity [GO:0003714]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; immune response [GO:0006955]; interferon-gamma-mediated signaling pathway [GO:0060333]; positive regulation of autophagy [GO:0010508]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein trimerization [GO:0070206]; protein ubiquitination [GO:0016567]; regulation of protein localization [GO:0032880]; regulation of transcription, DNA-templated [GO:0006355]; response to virus [GO:0009615]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IYM9-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8IYM9-2; Sequence=VSP_012060; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811}. Nucleus {ECO:0000269|PubMed:17156811}. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.


uniprotID: Q8IWZ4
geneSymbol: TRIM48
reactome: R-HSA-877300;
name: Tripartite motif-containing protein 48 (RING finger protein 101)
length: 208
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: I1YAP6
geneSymbol: TRIM77
name: Tripartite motif-containing protein 77
length: 450
go: ENSG00000214414;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: Q9C035
geneSymbol: TRIM5
reactome: R-HSA-877300;
pdb: 2ECV;2YRG;
length: 493
go: ENSG00000132256;
name:
Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; P-body [GO:0000932]; identical protein binding [GO:0042802]; protein binding, bridging [GO:0030674]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; signaling pattern recognition receptor activity [GO:0008329]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; activation of innate immune response [GO:0002218]; autophagy [GO:0006914]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of viral entry into host cell [GO:0046597]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein K63-linked ubiquitination [GO:0070534]; protein trimerization [GO:0070206]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of protein localization [GO:0032880]; viral process [GO:0016032]

snps:
rs59896509 rs3740996 rs61432120 rs56348930 rs11601507 rs10838525 rs11038628 rs28381981 rs59218593 rs7104422 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=Alpha; IsoId=Q9C035-1; Sequence=Displayed; Name=Beta; IsoId=Q9C035-2; Sequence=VSP_009010, VSP_009011; Note=Probable artifact.; Name=Gamma; IsoId=Q9C035-3; Sequence=VSP_009012, VSP_009013; Name=Delta; IsoId=Q9C035-4; Sequence=VSP_009014, VSP_009015; Name=Epsilon; Synonyms=Kappa; IsoId=Q9C035-5; Sequence=VSP_009016, VSP_009017; Name=Iota; IsoId=Q9C035-6; Sequence=VSP_044095, VSP_044096; Note=Has dominant-negative activity against TRIM5alpha. Does not inhibit HIV-1 replication.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25127057}. Nucleus {ECO:0000250|UniProtKB:Q0PF16}. Note=Predominantly localizes in cytoplasmic bodies (PubMed:12878161, PubMed:20357094). Localization may be influenced by the coexpression of other TRIM proteins, hence partial nuclear localization is observed in the presence of TRIM22 or TRIM27 (By similarity). In cytoplasmic bodies, colocalizes with proteasomal subunits and SQSTM1 (By similarity). {ECO:0000250|UniProtKB:Q0PF16, ECO:0000269|PubMed:12878161, ECO:0000269|PubMed:20357094, ECO:0000269|PubMed:25127057}.


uniprotID: Q96FX7
geneSymbol: TRMT61A
reactome: R-HSA-6782315;
pdb: 5CCB;5CCX;5CD1;
length: 289
go: ENSG00000166166;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P46959}.
name:
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA (m1A) methyltransferase complex [GO:0031515]; mRNA (adenine-N1-)-methyltransferase activity [GO:0061953]; tRNA (adenine-N1-)-methyltransferase activity [GO:0016429]; mRNA methylation [GO:0080009]; tRNA methylation [GO:0030488]


uniprotID: Q9UJA5
geneSymbol: TRMT6
reactome: R-HSA-6782315;
pdb: 5CCB;5CCX;5CD1;
length: 497
go: ENSG00000089195;
snps: rs6139876 rs451571 rs35203742
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41814}.
name:
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)

sequence:

opentargets:
nucleoplasm [GO:0005654]; tRNA (m1A) methyltransferase complex [GO:0031515]; RNA binding [GO:0003723]; mRNA methylation [GO:0080009]; tRNA methylation [GO:0030488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UJA5-1; Sequence=Displayed; Name=2; IsoId=Q9UJA5-2; Sequence=VSP_018025; Name=3; IsoId=Q9UJA5-3; Sequence=VSP_031100, VSP_031101; Note=No experimental confirmation available.; Name=4; IsoId=Q9UJA5-4; Sequence=VSP_054740; 


uniprotID: Q9NZQ8
geneSymbol: TRPM5
reactome: R-HSA-3295583;
length: 1165
go: ENSG00000070985;
snps: rs886277 rs3986599 rs34350821 rs34551253 rs4929982
name:
Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein)

sequence:

opentargets:
dendrite [GO:0030425]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; calcium activated cation channel activity [GO:0005227]; ion channel activity [GO:0005216]; potassium channel activity [GO:0005267]; sodium channel activity [GO:0005272]; voltage-gated ion channel activity [GO:0005244]; calcium ion transmembrane transport [GO:0070588]; regulation of ion transmembrane transport [GO:0034765]; sensory perception of taste [GO:0050909]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000269|PubMed:10607831, ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16554811}; IsoId=Q9NZQ8-1; Sequence=Displayed; Name=2 {ECO:0000269|Ref.4}; IsoId=Q9NZQ8-2; Sequence=VSP_052741; Name=3 {ECO:0000269|PubMed:10607831}; IsoId=Q9NZQ8-3; Sequence=VSP_052742, VSP_052743; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43, ECO:0000255}.


uniprotID: Q9H1D0
geneSymbol: TRPV6
reactome: R-HSA-3295583;
pdb: 6BO8;6BO9;6BOA;6D7S;6D7T;6E2F;
length: 765
go: ENSG00000165125;
snps: rs4987657 rs4987665 rs4987667 rs4987682
name:
Transient receptor potential cation channel subfamily V member 6 (TrpV6) (CaT-like) (CaT-L) (Calcium transport protein 1) (CaT1) (Epithelial calcium channel 2) (ECaC2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; ion channel activity [GO:0005216]; metal ion binding [GO:0046872]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; regulation of calcium ion-dependent exocytosis [GO:0017158]; response to calcium ion [GO:0051592]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H1D0-1; Sequence=Displayed; Name=2; IsoId=Q9H1D0-2; Sequence=VSP_013439; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11097838, ECO:0000269|PubMed:11248124, ECO:0000269|PubMed:11278579, ECO:0000269|PubMed:15184369, ECO:0000269|PubMed:23612980, ECO:0000269|PubMed:29258289}; Multi-pass membrane protein {ECO:0000269|PubMed:29258289}.


uniprotID: Q8WWH5
geneSymbol: TRUB1
name: Probable tRNA pseudouridine synthase 1 (EC 5.4.99.-)
length: 349
go: ENSG00000165832;
snps: rs34393297 rs7099565
sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; mRNA pseudouridine synthesis [GO:1990481]; tRNA modification [GO:0006400]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28073919}. Cytoplasm, cytosol {ECO:0000269|PubMed:28073919}. Note=Catalyzes pseudouridylation of mRNAs in the nucleus. {ECO:0000269|PubMed:28073919}.


uniprotID: O95900
geneSymbol: TRUB2
name: Mitochondrial mRNA pseudouridine synthase TRUB2 (EC 5.4.99.-)
length: 331
go: ENSG00000167112;
snps: rs2231630 rs2072394 rs2231637
sequence:

opentargets:
cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mitochondrial translation [GO:0070131]; pseudouridine synthesis [GO:0001522]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95900-1; Sequence=Displayed; Name=2; IsoId=O95900-2; Sequence=VSP_056094; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27974379}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.


uniprotID: Q7RTX0
geneSymbol: TAS1R3
reactome: R-HSA-418594;R-HSA-420499;
name: Taste receptor type 1 member 3 (Sweet taste receptor T1R3)
length: 852
go: ENSG00000169962;
snps: rs307377
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; sweet taste receptor complex [GO:1903767]; G protein-coupled receptor activity [GO:0004930]; protein heterodimerization activity [GO:0046982]; taste receptor activity [GO:0008527]; detection of chemical stimulus involved in sensory perception of sweet taste [GO:0001582]; G protein-coupled receptor signaling pathway [GO:0007186]; sensory perception of sweet taste [GO:0050916]; sensory perception of umami taste [GO:0050917]


uniprotID: Q96A04
geneSymbol: TSACC
name: TSSK6-activating co-chaperone protein (SSTK-interacting protein) (SSTK-IP)
length: 125
go: ENSG00000163467;
opentargets: cytoplasm [GO:0005737]; chaperone binding [GO:0051087]
snps: rs41265043
sequence:
MERHTSHPNRKVPAKEEANAVPLCRAKPSPSYINLQASSPPATFLNIQTTKLPSVDHKPKECLGLLECMYANLQLQTQLAQQQMAVLEHLQASVTQLAPGRGSNNSSLPALSPNPLLNHLPQFSK


uniprotID: Q15661
geneSymbol: TPSAB1
reactome: R-HSA-1592389;
pdb: 1LTO;2F9N;2F9O;2F9P;2ZEB;2ZEC;4A6L;4MPU;4MPV;4MPW;4MPX;4MQA;5F03;5WI6;
name: Tryptase alpha/beta-1 (Tryptase-1) (EC 3.4.21.59) (Tryptase I) (Tryptase alpha-1)
length: 275
go: ENSG00000172236;
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; defense response [GO:0006952]; extracellular matrix disassembly [GO:0022617]; proteolysis [GO:0006508]

snps:
rs371929937 rs761476435 rs562518617 rs141519544 rs146223687 rs112944038 rs1060281 rs17841227 rs17841226 rs151324823 rs201351744 rs199625169 rs202044288 rs144979264 rs200334042 rs1064780 rs1800992 rs143210825 rs202156919 rs201345428 rs1060284 rs2234905 rs2234906 rs201192435 rs145402040 rs200355084 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15661-1; Sequence=Displayed; Name=2; IsoId=Q15661-2; Sequence=VSP_005375; 

location:
SUBCELLULAR LOCATION: Secreted. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.


uniprotID: Q12999
geneSymbol: TSPAN31
name: Tetraspanin-31 (Tspan-31) (Sarcoma-amplified sequence)
length: 210
go: ENSG00000135452;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of cell proliferation [GO:0008284]


uniprotID: Q8NDW8
geneSymbol: TTC21A
name: Tetratricopeptide repeat protein 21A (TPR repeat protein 21A) (Stress-inducible protein 2)
length: 1320
go: ENSG00000168026;
sequence:

opentargets:
cilium [GO:0005929]; intraciliary transport particle A [GO:0030991]; intraciliary retrograde transport [GO:0035721]; protein localization to cilium [GO:0061512]

snps:
rs1112438 rs17855763 rs1274972 rs1274971 rs35581078 rs9861353 rs9861353 rs35934336 rs34201693 rs704959 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8NDW8-1; Sequence=Displayed; Name=3; IsoId=Q8NDW8-3; Sequence=VSP_026297; Note=No experimental confirmation available.; Name=5; IsoId=Q8NDW8-5; Sequence=VSP_038429, VSP_038430, VSP_038431; Note=No experimental confirmation available.; Name=6; IsoId=Q8NDW8-6; Sequence=VSP_038428, VSP_038429, VSP_038431; Note=No experimental confirmation available.; Name=7; IsoId=Q8NDW8-7; Sequence=VSP_038431; Note=No experimental confirmation available.; 


uniprotID: O95859
geneSymbol: TSPAN12
name: Tetraspanin-12 (Tspan-12) (Tetraspan NET-2) (Transmembrane 4 superfamily member 12)
length: 305
go: ENSG00000106025;
snps: rs538591733 rs17852934 rs267607152 rs587777283 rs267607151 rs267607154
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; angiogenesis [GO:0001525]; cell surface receptor signaling pathway [GO:0007166]; regulation of angiogenesis [GO:0045765]; retina layer formation [GO:0010842]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95859-1; Sequence=Displayed; Name=2; IsoId=O95859-2; Sequence=VSP_038525; Note=No experimental confirmation available.; 


uniprotID: Q99598
geneSymbol: TSNAX
reactome: R-HSA-426486;
pdb: 3PJA;3QB5;
name: Translin-associated protein X (Translin-associated factor X)
length: 290
go: ENSG00000116918;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; A2A adenosine receptor binding [GO:0031687]; DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; metal ion binding [GO:0046872]; protein transporter activity [GO:0008565]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid-late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}.


uniprotID: Q9UJT2
geneSymbol: TSKS
name: Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1)
length: 592
go: ENSG00000126467;
snps: rs149529240 rs34701020 rs2304202
sequence:

opentargets:
centriole [GO:0005814]; protein kinase binding [GO:0019901]; negative regulation of phosphatase activity [GO:0010923]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UJT2-1; Sequence=Displayed; Name=2; IsoId=Q9UJT2-2; Sequence=VSP_009591, VSP_009592, VSP_009593; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Concentrates in spermatid centrioles during flagellogenesis.


uniprotID: O60635
geneSymbol: TSPAN1
name: Tetraspanin-1 (Tspan-1) (Tetraspan NET-1) (Tetraspanin TM4-C)
length: 241
go: ENSG00000117472;
snps: rs2234267 rs2234268
sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; positive regulation of endocytosis [GO:0045807]; protein stabilization [GO:0050821]

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19508227}; Multi-pass membrane protein {ECO:0000269|PubMed:19508227}.


uniprotID: Q9H489
geneSymbol: TSPY26P
length: 355
opentargets: nucleus [GO:0005634]; nucleosome assembly [GO:0006334]
snps: rs3813922
name:
Putative testis-specific Y-encoded-like protein 3 (TSPY-like protein 3) (Testis-specific Y-encoded protein 26 pseudogene)

sequence:


uniprotID: Q8NBP0
geneSymbol: TTC13
name: Tetratricopeptide repeat protein 13 (TPR repeat protein 13)
length: 860
go: ENSG00000143643;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NBP0-1; Sequence=Displayed; Name=2; IsoId=Q8NBP0-2; Sequence=VSP_011644, VSP_035660; 


uniprotID: Q8NEE8
geneSymbol: TTC16
name: Tetratricopeptide repeat protein 16 (TPR repeat protein 16)
length: 873
go: ENSG00000167094;
snps: rs17852941 rs13298768 rs4837178 rs17852943
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NEE8-1; Sequence=Displayed; Name=2; IsoId=Q8NEE8-2; Sequence=VSP_056854, VSP_056855, VSP_056856; Note=No experimental confirmation available.; 


uniprotID: Q5JU69
geneSymbol: TOR2A
name: Torsin-2A (Torsin family 2 member A) (Torsin-related protein 1)
length: 321
go: ENSG00000160404;
snps: rs538066
location: SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; ATP binding [GO:0005524]; chaperone cofactor-dependent protein refolding [GO:0051085]; protein homooligomerization [GO:0051260]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5JU69-1; Sequence=Displayed; Name=2; IsoId=Q5JU69-2; Sequence=VSP_017703, VSP_017704; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=Q5JU69-5; Sequence=VSP_035631, VSP_035632; Note=No experimental confirmation available.; Name=4; IsoId=Q8N2E6-1; Sequence=External; Note=Salusins -alpha and -beta peptides are derived from isoform 4.; 


uniprotID: Q93096
geneSymbol: PTP4A1
pdb: 1RXD;1XM2;5BX1;
length: 173
go: ENSG00000112245;
name:
Protein tyrosine phosphatase type IVA 1 (EC 3.1.3.48) (PTP(CAAXI)) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1)

sequence:
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

opentargets:
cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; spindle [GO:0005819]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cell cycle [GO:0007049]; multicellular organism development [GO:0007275]; positive regulation of cell migration [GO:0030335]

location:
SUBCELLULAR LOCATION: Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.


uniprotID: Q9NS56
geneSymbol: TOPORS
reactome: R-HSA-3899300;R-HSA-4085377;R-HSA-4755510;
length: 1045
go: ENSG00000197579;
snps: rs17855104 rs17855103 rs17857515 rs36034138
name:
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)

sequence:

opentargets:
centriole [GO:0005814]; ciliary basal body [GO:0036064]; gamma-tubulin complex [GO:0000930]; midbody [GO:0030496]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; photoreceptor connecting cilium [GO:0032391]; PML body [GO:0016605]; spindle pole [GO:0000922]; ubiquitin ligase complex [GO:0000151]; antigen binding [GO:0003823]; DNA binding [GO:0003677]; DNA topoisomerase binding [GO:0044547]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; maintenance of protein location in nucleus [GO:0051457]; negative regulation of apoptotic process [GO:0043066]; photoreceptor cell outer segment organization [GO:0035845]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein localization to nucleus [GO:0034504]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein sumoylation [GO:0016925]; regulation of cell proliferation [GO:0042127]; retina layer formation [GO:0010842]; retinal cone cell development [GO:0046549]; retinal rod cell development [GO:0046548]; transcription, DNA-templated [GO:0006351]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=LUN-1; IsoId=Q9NS56-1; Sequence=Displayed; Name=2; Synonyms=LUN-2; IsoId=Q9NS56-2; Sequence=VSP_017916, VSP_017917; 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.


uniprotID: P20333
geneSymbol: TNFRSF1B
reactome: R-HSA-5668541;R-HSA-5669034;R-HSA-6783783;R-HSA-6785807;R-HSA-6798695;
pdb: 1CA9;3ALQ;
length: 461
go: ENSG00000028137;
drug: DB00005;
snps: rs2228494 rs1061622 rs5746026 rs5746027 rs2229700 rs17879042 rs5746032 rs17883432
name:
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tumor necrosis factor receptor superfamily complex [GO:0002947]; varicosity [GO:0043196]; tumor necrosis factor binding [GO:0043120]; tumor necrosis factor-activated receptor activity [GO:0005031]; ubiquitin protein ligase binding [GO:0031625]; aging [GO:0007568]; aortic valve development [GO:0003176]; cellular response to growth factor stimulus [GO:0071363]; cellular response to lipopolysaccharide [GO:0071222]; cytokine-mediated signaling pathway [GO:0019221]; extrinsic apoptotic signaling pathway [GO:0097191]; inflammatory response [GO:0006954]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of inflammatory response [GO:0050728]; neutrophil degranulation [GO:0043312]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; pulmonary valve development [GO:0003177]; RNA destabilization [GO:0050779]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P20333-1; Sequence=Displayed; Name=2; Synonyms=DS-TNFR2(Delta7,8), sTNFR2; IsoId=P20333-2; Sequence=VSP_011826, VSP_011827; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.; SUBCELLULAR LOCATION: Tumor necrosis factor-binding protein 2: Secreted.


uniprotID: Q9BW30
geneSymbol: TPPP3
pdb: 2JRF;
name: Tubulin polymerization-promoting protein family member 3 (TPPP/p20)
length: 176
go: ENSG00000159713;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305|PubMed:17105200}.
sequence:
MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; tubulin binding [GO:0015631]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein polymerization [GO:0032273]


uniprotID: Q9UL33
geneSymbol: TRAPPC2L
reactome: R-HSA-204005;R-HSA-8876198;
name: Trafficking protein particle complex subunit 2-like protein
length: 140
go: ENSG00000167515;
sequence:
MAVCIAVIAKENYPLYIRSTPTENELKFHYMVHTSLDVVDEKISAMGKALVDQRELYLGLLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSSRAFDNMVTSMMIQVC

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; COPII vesicle coating [GO:0048208]; protein complex oligomerization [GO:0051259]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UL33-1; Sequence=Displayed; Name=2; IsoId=Q9UL33-2; Sequence=VSP_026641; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19416478}. Endoplasmic reticulum {ECO:0000269|PubMed:19416478}. Golgi apparatus {ECO:0000269|PubMed:19416478}.


uniprotID: Q9BX59
geneSymbol: TAPBPL
pdb: 5WER;
length: 468
go: ENSG00000139192;
snps: rs2041385 rs2532501 rs7295376 rs2532500 rs2041387 rs1045546
name:
Tapasin-related protein (TAPASIN-R) (TAP-binding protein-like) (TAP-binding protein-related protein) (TAPBP-R) (Tapasin-like)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; immune system process [GO:0002376]; negative regulation of antigen processing and presentation of peptide antigen via MHC class I [GO:0002590]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=alpha; IsoId=Q9BX59-1; Sequence=Displayed; Name=beta; IsoId=Q9BX59-2; Sequence=VSP_057096; Note=Has reduced cell surface expression, and does not down-regulate MHC class I surface expression as efficiently as isoform alpha.; Name=gamma; IsoId=Q9BX59-3; Sequence=VSP_057094; Note=Does not interact with MHC class I.; Name=delta; IsoId=Q9BX59-4; Sequence=VSP_057091, VSP_057092; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=epsilon; IsoId=Q9BX59-5; Sequence=VSP_057089; Name=eta; IsoId=Q9BX59-6; Sequence=VSP_057090, VSP_057093; Name=zeta; IsoId=Q9BX59-7; Sequence=VSP_057095; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Microsome membrane {ECO:0000305|PubMed:11920573}; Single-pass type I membrane protein {ECO:0000305|PubMed:11920573}. Golgi apparatus membrane {ECO:0000269|PubMed:23401559}; Single-pass type I membrane protein {ECO:0000269|PubMed:23401559}. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface (PubMed:11920573).


uniprotID: Q15633
geneSymbol: TARBP2
reactome: R-HSA-203927;R-HSA-426486;
pdb: 2CPN;3ADL;3LLH;4WYQ;5N8L;5N8M;5ZAK;5ZAL;5ZAM;
length: 366
go: ENSG00000139546;
snps: rs1126500
location: SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
name:
RISC-loading complex subunit TARBP2 (TAR RNA-binding protein 2) (Trans-activation-responsive RNA-binding protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; micro-ribonucleoprotein complex [GO:0035068]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; RISC complex [GO:0016442]; RISC-loading complex [GO:0070578]; double-stranded RNA binding [GO:0003725]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; pre-miRNA binding [GO:0070883]; pre-mRNA binding [GO:0036002]; protein homodimerization activity [GO:0042803]; protein N-terminus binding [GO:0047485]; siRNA binding [GO:0035197]; miRNA loading onto RISC involved in gene silencing by miRNA [GO:0035280]; miRNA metabolic process [GO:0010586]; multicellular organism growth [GO:0035264]; negative regulation of defense response to virus by host [GO:0050689]; negative regulation of protein kinase activity [GO:0006469]; neural precursor cell proliferation [GO:0061351]; positive regulation of muscle cell differentiation [GO:0051149]; positive regulation of translation [GO:0045727]; positive regulation of viral genome replication [GO:0045070]; pre-miRNA processing [GO:0031054]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; production of siRNA involved in RNA interference [GO:0030422]; regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903798]; regulation of production of siRNA involved in RNA interference [GO:0090065]; regulation of viral transcription [GO:0046782]; single fertilization [GO:0007338]; siRNA loading onto RISC involved in RNA interference [GO:0035087]; skeletal muscle tissue regeneration [GO:0043403]; spermatid development [GO:0007286]; targeting of mRNA for destruction involved in RNA interference [GO:0030423]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage; Named isoforms=2;  Name=1; Synonyms=TRBP2; IsoId=Q15633-1; Sequence=Displayed; Name=2; Synonyms=TRBP1; IsoId=Q15633-2; Sequence=VSP_035584; 


uniprotID: P01848
geneSymbol: TRAC
reactome: R-HSA-198933;R-HSA-202424;R-HSA-202427;R-HSA-202430;R-HSA-202433;R-HSA-389948;
name: T cell receptor alpha constant
length: 140
drug: DB02740;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
pdb:
1AO7;1BD2;1FYT;1J8H;1KGC;1MI5;1OGA;1QRN;1QSF;1YMM;1ZGL;2AK4;2BNQ;2BNR;2BNU;2CDF;2CDG;2ESV;2EYR;2EYS;2EYT;2F53;2F54;2GJ6;2IAL;2IAM;2IAN;2NX5;2P5E;2P5W;2PO6;2PYE;2PYF;2VLJ;2VLK;2VLM;2VLR;2XN9;2XNA;3ARB;3ARD;3ARE;3ARF;3ARG;3D39;3DX9;3DXA;3FFC;3GSN;3HE7;3HG1;3KPR;3KPS;3KXF;3O4L;3O6F;3O8X;3O9W;3PWP;3QDG;3QDJ;3QDM;3QEQ;3QEU;3QIB;3QJF;3QUX;3SCM;3SDA;3SDC;3SDD;3SDX;3SJV;3SKN;3T0E;3TN0;3TVM;4APQ;4C56;4G8E;4G8F;4IRS;4JFD;4JFE;4JFF;4JFH;4JRX;4JRY;4MVB;4MXQ;4N0C;4N5E;4NHU;4ONH;4P4K;4PRH;4PRI;4PRP;4UDT;4UDU;4WW1;4WW2;4WWK;4X6B;4X6C;4X6D;4Y16;4Y2D;4Y4F;4Y4H;4Y4K;4ZDH;5BRZ;5BS0;5C07;5C08;5C09;5C0A;5C0B;5C0C;5EU6;5FK9;5FKA;5HHM;5HHO;5HYJ;5JZI;5KS9;5KSA;5KSB;5NQK;

sequence:
IQNPDPAVYQLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKTVLDMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPSPESSCDVKLVEKSFETDTNLNFQNLSVIGFRILLLKVAGFNLLMTLRLWSS

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; regulation of immune response [GO:0050776]; T cell receptor signaling pathway [GO:0050852]


uniprotID: Q495X7
geneSymbol: TRIM60
name: Tripartite motif-containing protein 60 (RING finger protein 129) (RING finger protein 33)
length: 471
go: ENSG00000176979;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: Q7Z4G4
geneSymbol: TRMT11
reactome: R-HSA-6782315;
length: 463
go: ENSG00000066651;
opentargets: tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]
snps: rs17854915
name:
tRNA (guanine(10)-N2)-methyltransferase homolog (EC 2.1.1.-) (tRNA guanosine-2'-O-methyltransferase TRM11 homolog)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z4G4-1; Sequence=Displayed; Name=2; IsoId=Q7Z4G4-2; Sequence=VSP_017818; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z4G4-3; Sequence=VSP_017816, VSP_017817; 


uniprotID: Q9C040
geneSymbol: TRIM2
reactome: R-HSA-877300;
length: 744
go: ENSG00000109654;
snps: rs587777063
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ESN6}.
name:
Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)

sequence:

opentargets:
cytoplasm [GO:0005737]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; regulation of neuron apoptotic process [GO:0043523]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9C040-1; Sequence=Displayed; Name=2; IsoId=Q9C040-2; Sequence=VSP_046923; 


uniprotID: Q86XT4
geneSymbol: TRIM50
reactome: R-HSA-983168;
length: 487
snps: rs6980124
name:
E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50)

sequence:

opentargets:
aggresome [GO:0016235]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; regulation of establishment of protein localization [GO:0070201]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Alpha; IsoId=Q86XT4-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=Beta; IsoId=Q86XT4-2; Sequence=VSP_012088; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:24308962, ECO:0000269|PubMed:29604308}. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins. {ECO:0000269|PubMed:22792322}.


uniprotID: Q86UV7
geneSymbol: TRIM73
name: Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B)
length: 250
go: ENSG00000178809;
opentargets: cytosol [GO:0005829]; zinc ion binding [GO:0008270]
sequence:


uniprotID: Q9C019
geneSymbol: TRIM15
length: 465
go: ENSG00000204610;
snps: rs17194460 rs17194467 rs17194474 rs34823152 rs929156
name:
Tripartite motif-containing protein 15 (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)

sequence:

opentargets:
intracellular [GO:0005622]; zinc ion binding [GO:0008270]; innate immune response [GO:0045087]; mesodermal cell fate determination [GO:0007500]; negative regulation of intracellular transport of viral material [GO:1901253]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of RIG-I signaling pathway [GO:1900246]; positive regulation of type I interferon production [GO:0032481]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Alpha; IsoId=Q9C019-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9C019-2; Sequence=VSP_005760, VSP_005761; 


uniprotID: O94759
geneSymbol: TRPM2
reactome: R-HSA-3295583;R-HSA-6798695;
length: 1503
go: ENSG00000142185;
name:
Transient receptor potential cation channel subfamily M member 2 (Estrogen-responsive element-associated gene 1 protein) (Long transient receptor potential channel 2) (LTrpC-2) (LTrpC2) (Transient receptor potential channel 7) (TrpC7) (Transient receptor potential melastatin 2)

sequence:

opentargets:
cell projection [GO:0042995]; cytoplasmic vesicle membrane [GO:0030659]; ficolin-1-rich granule membrane [GO:0101003]; integral component of plasma membrane [GO:0005887]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; calcium channel activity [GO:0005262]; calcium ion binding [GO:0005509]; calcium-release channel activity [GO:0015278]; cation channel activity [GO:0005261]; ligand-gated calcium channel activity [GO:0099604]; sodium channel activity [GO:0005272]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane import into cytosol [GO:0097553]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to calcium ion [GO:0071277]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to purine-containing compound [GO:0071415]; cellular response to temperature stimulus [GO:0071502]; dendritic cell chemotaxis [GO:0002407]; dendritic cell differentiation [GO:0097028]; neutrophil degranulation [GO:0043312]; regulation of actin cytoskeleton reorganization [GO:2000249]; regulation of filopodium assembly [GO:0051489]; release of sequestered calcium ion into cytosol [GO:0051209]; response to purine-containing compound [GO:0014074]; temperature homeostasis [GO:0001659]; zinc ion transmembrane transport [GO:0071577]

snps:
rs45625933 rs45544142 rs45485992 rs1556314 rs9974927 rs9978351 rs45611537 rs45519835 rs45513700 rs45589233 rs45570639 rs45613636 rs45578242 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TRPM2-L; IsoId=O94759-1; Sequence=Displayed; Name=2; IsoId=O94759-2; Sequence=VSP_006574, VSP_006575; Name=3; Synonyms=TRPM2-S; IsoId=O94759-3; Sequence=VSP_013018; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11385575, ECO:0000269|PubMed:11509734, ECO:0000269|PubMed:11804595, ECO:0000269|PubMed:12594222, ECO:0000269|PubMed:15561722, ECO:0000269|PubMed:16601673, ECO:0000269|PubMed:19171771, ECO:0000269|PubMed:20650899, ECO:0000269|PubMed:20660597, ECO:0000269|PubMed:22493272, ECO:0000269|PubMed:25918360, ECO:0000269|PubMed:27068538, ECO:0000269|PubMed:27383051}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000250|UniProtKB:E9PTA2}. Cell projection {ECO:0000250|UniProtKB:E9PTA2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:E9PTA2}. Lysosome {ECO:0000269|PubMed:27068538}. Note=Detected at the cell membrane and in intracellular vesicles in cortical neurons. Detected on neuronal cell bodies and neurites (By similarity). Detected on the cell membrane in polymorphonuclear neutrophils. Detected on cytoplasmic vesicles and lysosomes in immature bone marrow dendritic cells (By similarity). {ECO:0000250|UniProtKB:E9PTA2, ECO:0000250|UniProtKB:Q91YD4}.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:11960981, ECO:0000269|PubMed:12594222}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000269|PubMed:11960981}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane {ECO:0000269|PubMed:12594222}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9UHF7
geneSymbol: TRPS1
length: 1281
go: ENSG00000104447;
snps: rs7002384 rs121908433 rs121908435 rs1057518972 rs28939069 rs28939070
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12885770}.
name:
Zinc finger transcription factor Trps1 (Tricho-rhino-phalangeal syndrome type I protein) (Zinc finger protein GC79)

sequence:

opentargets:
nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; protein domain specific binding [GO:0019904]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NLS-bearing protein import into nucleus [GO:0006607]; protein heterooligomerization [GO:0051291]; regulation of chondrocyte differentiation [GO:0032330]; skeletal system development [GO:0001501]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UHF7-1; Sequence=Displayed; Name=2; IsoId=Q9UHF7-2; Sequence=VSP_037549; Name=3; IsoId=Q9UHF7-3; Sequence=VSP_037550; 


uniprotID: Q8NER1
geneSymbol: TRPV1
reactome: R-HSA-3295583;
length: 839
go: ENSG00000196689;
drug: DB00316;DB00132;DB00168;DB06774;DB00159;
snps: rs222749 rs222747 rs224534 rs17633288 rs8065080
name:
Transient receptor potential cation channel subfamily V member 1 (TrpV1) (Capsaicin receptor) (Osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1)

sequence:

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; dendritic spine membrane [GO:0032591]; external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; ATP binding [GO:0005524]; calcium channel activity [GO:0005262]; calcium-release channel activity [GO:0015278]; calmodulin binding [GO:0005516]; chloride channel regulator activity [GO:0017081]; excitatory extracellular ligand-gated ion channel activity [GO:0005231]; extracellular ligand-gated ion channel activity [GO:0005230]; identical protein binding [GO:0042802]; ion channel activity [GO:0005216]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; phosphoprotein binding [GO:0051219]; temperature-gated ion channel activity [GO:0097603]; transmembrane signaling receptor activity [GO:0004888]; behavioral response to pain [GO:0048266]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; cell surface receptor signaling pathway [GO:0007166]; cellular response to acidic pH [GO:0071468]; cellular response to alkaloid [GO:0071312]; cellular response to ATP [GO:0071318]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to temperature stimulus [GO:0071502]; cellular response to tumor necrosis factor [GO:0071356]; chemosensory behavior [GO:0007635]; detection of chemical stimulus involved in sensory perception of pain [GO:0050968]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; detection of temperature stimulus involved in thermoception [GO:0050960]; diet induced thermogenesis [GO:0002024]; fever generation [GO:0001660]; glutamate secretion [GO:0014047]; lipid metabolic process [GO:0006629]; microglial cell activation [GO:0001774]; negative regulation of establishment of blood-brain barrier [GO:0090212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; peptide secretion [GO:0002790]; positive regulation of apoptotic process [GO:0043065]; positive regulation of gastric acid secretion [GO:0060454]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; protein homotetramerization [GO:0051289]; response to capsazepine [GO:1901594]; response to peptide hormone [GO:0043434]; sensory perception of mechanical stimulus [GO:0050954]; smooth muscle contraction involved in micturition [GO:0060083]; thermoception [GO:0050955]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NER1-1; Sequence=Displayed; Name=2; IsoId=Q8NER1-3; Sequence=VSP_056862; 

location:
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:O35433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35433}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:O35433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35433}. Cell membrane {ECO:0000269|PubMed:11050376, ECO:0000269|PubMed:11243859, ECO:0000269|PubMed:12077606}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35433}. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines. {ECO:0000250|UniProtKB:O35433}.


uniprotID: Q8NET8
geneSymbol: TRPV3
reactome: R-HSA-3295583;
length: 790
go: ENSG00000167723;
drug: DB00825;
snps: rs322965 rs322937 rs199473704 rs199473704 rs786205869 rs199473705 rs7212634
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium channel activity [GO:0005262]; ion channel activity [GO:0005216]; calcium ion transmembrane transport [GO:0070588]; negative regulation of hair cycle [GO:0042636]; positive regulation of calcium ion import [GO:0090280]; response to heat [GO:0009408]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NET8-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q8NET8-2; Sequence=VSP_013433; Name=3; Synonyms=B; IsoId=Q8NET8-3; Sequence=VSP_013434, VSP_013435; 


uniprotID: Q9HBA0
geneSymbol: TRPV4
reactome: R-HSA-3295583;
pdb: 4DX1;4DX2;
length: 871
go: ENSG00000111199;
name:
Transient receptor potential cation channel subfamily V member 4 (TrpV4) (Osm-9-like TRP channel 4) (OTRPC4) (Transient receptor potential protein 12) (TRP12) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC)

sequence:

opentargets:
adherens junction [GO:0005912]; apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; cortical actin cytoskeleton [GO:0030864]; cytoplasmic microtubule [GO:0005881]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; cation channel activity [GO:0005261]; identical protein binding [GO:0042802]; ion channel activity [GO:0005216]; lipid binding [GO:0008289]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; osmosensor activity [GO:0005034]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; SH2 domain binding [GO:0042169]; stretch-activated, cation-selective, calcium channel activity [GO:0015275]; actin cytoskeleton reorganization [GO:0031532]; actin filament organization [GO:0007015]; blood vessel endothelial cell delamination [GO:0097497]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; cartilage development involved in endochondral bone morphogenesis [GO:0060351]; cell volume homeostasis [GO:0006884]; cell-cell junction assembly [GO:0007043]; cellular calcium ion homeostasis [GO:0006874]; cellular hypotonic response [GO:0071476]; cellular hypotonic salinity response [GO:0071477]; cellular response to heat [GO:0034605]; cellular response to osmotic stress [GO:0071470]; cortical microtubule organization [GO:0043622]; diet induced thermogenesis [GO:0002024]; energy homeostasis [GO:0097009]; glucose homeostasis [GO:0042593]; hyperosmotic salinity response [GO:0042538]; microtubule polymerization [GO:0046785]; multicellular organismal water homeostasis [GO:0050891]; negative regulation of brown fat cell differentiation [GO:1903444]; negative regulation of neuron projection development [GO:0010977]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osmosensory signaling pathway [GO:0007231]; positive regulation of chemokine (C-C motif) ligand 5 production [GO:0071651]; positive regulation of chemokine (C-X-C motif) ligand 1 production [GO:2000340]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of macrophage inflammatory protein 1 alpha production [GO:0071642]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of vascular permeability [GO:0043117]; regulation of response to osmotic stress [GO:0047484]; response to insulin [GO:0032868]; response to mechanical stimulus [GO:0009612]; signal transduction involved in regulation of aerobic respiration [GO:1903759]; vasopressin secretion [GO:0030103]

snps:
rs3742030 rs397514473 rs876661124 rs387906324 rs387906903 rs515726167 rs387906904 rs267607146 rs267607144 rs387907220 rs387907219 rs515726170 rs267607148 rs515726171 rs267607143 rs267607145 rs387906905 rs121912636 rs515726172 rs121912634 rs515726152 rs387906902 rs515726158 rs77975504 rs515726159 rs515726160 rs267607150 rs515726161 rs121912632 rs515726162 rs515726163 rs121912633 rs515726164 rs116571438 rs121912635 rs515726165 rs267607149 rs267607147 rs121912637 rs121912637 rs267607147 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=A; IsoId=Q9HBA0-1; Sequence=Displayed; Name=2; Synonyms=B, OTRPC4beta; IsoId=Q9HBA0-2; Sequence=VSP_013436; Note=Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}; Name=3; Synonyms=TRPV-SV; IsoId=Q9HBA0-3; Sequence=VSP_013437; Name=4; Synonyms=C; IsoId=Q9HBA0-4; Sequence=VSP_026615; Note=Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}; Name=5; Synonyms=D; IsoId=Q9HBA0-5; Sequence=VSP_026614; Note=Forms active ion channels. {ECO:0000269|PubMed:16293632}; Name=6; Synonyms=E; IsoId=Q9HBA0-6; Sequence=VSP_026615, VSP_013436; Note=Lacks channel activity, due to impaired oligomerization and intracellular retention. {ECO:0000269|PubMed:16293632}; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:18826956}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9EPK8}. Cell projection, cilium {ECO:0000269|PubMed:18695040}. Note=Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. {ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:20037587, ECO:0000269|PubMed:20037588}.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:16293632, ECO:0000269|PubMed:21964574, ECO:0000269|PubMed:25256292}.; SUBCELLULAR LOCATION: Isoform 5: Cell membrane {ECO:0000269|PubMed:16293632}.; SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.; SUBCELLULAR LOCATION: Isoform 4: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.; SUBCELLULAR LOCATION: Isoform 6: Endoplasmic reticulum {ECO:0000269|PubMed:16293632}.


uniprotID: Q9NQA5
geneSymbol: TRPV5
reactome: R-HSA-3295583;
pdb: 5OEO;
length: 729
snps: rs4252372 rs4236480 rs4252499 rs4252509
name:
Transient receptor potential cation channel subfamily V member 5 (TrpV5) (Calcium transport protein 2) (CaT2) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Osm-9-like TRP channel 3) (OTRPC3)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; calmodulin binding [GO:0005516]; ion channel activity [GO:0005216]; metal ion binding [GO:0046872]; calcium ion homeostasis [GO:0055074]; calcium ion import across plasma membrane [GO:0098703]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; protein homotetramerization [GO:0051289]; protein tetramerization [GO:0051262]; regulation of urine volume [GO:0035809]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NQA5-1; Sequence=Displayed; Name=2; IsoId=Q9NQA5-2; Sequence=VSP_057199, VSP_057200; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590). {ECO:0000250|UniProtKB:P69744, ECO:0000269|PubMed:18768590}.


uniprotID: Q9Y4A5
geneSymbol: TRRAP
reactome: R-HSA-201722;R-HSA-3214847;R-HSA-5689880;
length: 3859
go: ENSG00000196367;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9708738}.
name:
Transformation/transcription domain-associated protein (350/400 kDa PCAF-associated factor) (PAF350/400) (STAF40) (Tra1 homolog)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; NuA4 histone acetyltransferase complex [GO:0035267]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCAF complex [GO:0000125]; SAGA complex [GO:0000124]; STAGA complex [GO:0030914]; Swr1 complex [GO:0000812]; transcription factor TFTC complex [GO:0033276]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transcription coregulator activity [GO:0003712]; beta-catenin-TCF complex assembly [GO:1904837]; histone acetylation [GO:0016573]; histone deubiquitination [GO:0016578]; histone H2A acetylation [GO:0043968]; histone H4 acetylation [GO:0043967]; protein deubiquitination [GO:0016579]; regulation of transcription, DNA-templated [GO:0006355]

snps:
rs147405090 rs17161510 rs55920979 rs373632999 rs782203759 rs56197298 rs34185633 rs528967912 rs35634065 rs753661271 rs55755466 rs56341061 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y4A5-1; Sequence=Displayed; Name=2; IsoId=Q9Y4A5-2; Sequence=VSP_009102, VSP_009103; 


uniprotID: Q9BZJ3
geneSymbol: TPSD1
length: 242
go: ENSG00000095917;
snps: rs3865205 rs1800984 rs1141967
name:
Tryptase delta (EC 3.4.21.59) (Delta-tryptase) (HmMCP-3-like tryptase III) (Mast cell mMCP-7-like) (Tryptase-3)

sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BZJ3-1; Sequence=Displayed; Name=2; IsoId=Q9BZJ3-2; Sequence=VSP_008319; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Released from the secretory granules upon mast cell activation. {ECO:0000250}.


uniprotID: Q9NNW7
geneSymbol: TXNRD2
reactome: R-HSA-3299685;
pdb: 1W1E;
length: 524
go: ENSG00000184470;
drug: DB05428;
snps: rs45593642 rs5748469 rs5992495 rs1139793
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10215850}.
name:
Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; thioredoxin-disulfide reductase activity [GO:0004791]; cell redox homeostasis [GO:0045454]; cellular response to oxidative stress [GO:0034599]; response to oxygen radical [GO:0000305]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha {ECO:0000305}; IsoId=Q9NNW7-1; Sequence=Displayed; Name=2; Synonyms=Beta {ECO:0000305}; IsoId=Q9NNW7-2; Sequence=VSP_008304; Name=3; Synonyms=SelZf2; IsoId=Q9NNW7-3; Sequence=VSP_008305; Name=4; Synonyms=SelZf1; IsoId=Q9NNW7-4; Sequence=VSP_008306; 


uniprotID: Q8NCL8
geneSymbol: TMEM116
name: Transmembrane protein 116
length: 245
go: ENSG00000198270;
opentargets: integral component of membrane [GO:0016021]
snps: rs3752630
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NCL8-1; Sequence=Displayed; Name=2; IsoId=Q8NCL8-2; Sequence=VSP_046988; Note=No experimental confirmation available.; Name=3; IsoId=Q8NCL8-3; Sequence=VSP_046987; Note=No experimental confirmation available.; 


uniprotID: Q9NV29
geneSymbol: TMEM100
name: Transmembrane protein 100
length: 134
go: ENSG00000166292;
sequence:
MTEEPIKEILGAPKAHMAATMEKSPKSEVVITTVPLVSEIQLMAATGGTELSCYRCIIPFAVVVFIAGIVVTAVAYSFNSHGSIISIFGLVVLSSGLFLLASSALCWKVRQRSKKAKRRESQTALVANQRSLFA

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; angiogenesis [GO:0001525]; arterial endothelial cell differentiation [GO:0060842]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; in utero embryonic development [GO:0001701]; Notch signaling pathway [GO:0007219]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of vasculogenesis [GO:2001214]; protein kinase B signaling [GO:0043491]; regulation of calcium-mediated signaling [GO:0050848]; regulation of sensory perception of pain [GO:0051930]; vasculogenesis [GO:0001570]

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.


uniprotID: Q02880
geneSymbol: TOP2B
reactome: R-HSA-4615885;
pdb: 3QX3;4G0U;4G0V;4G0W;4J3N;5GWI;5GWJ;5ZEN;5ZQF;5ZRF;
name: DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)
length: 1626
go: ENSG00000077097;
drug: DB08651;DB05488;DB05022;DB00970;DB00694;DB00380;DB00773;DB04395;DB06042;
snps: rs886039770
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; viral integration complex [GO:0019035]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type II (ATP-hydrolyzing) activity [GO:0003918]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein C-terminus binding [GO:0008022]; protein heterodimerization activity [GO:0046982]; protein kinase C binding [GO:0005080]; axonogenesis [GO:0007409]; DNA topological change [GO:0006265]; forebrain development [GO:0030900]; mitotic DNA integrity checkpoint [GO:0044774]; neuron migration [GO:0001764]; positive regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045870]; resolution of meiotic recombination intermediates [GO:0000712]; sister chromatid segregation [GO:0000819]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Beta-2; IsoId=Q02880-1; Sequence=Displayed; Name=Beta-1; IsoId=Q02880-2; Sequence=VSP_006532; 


uniprotID: Q8N2E6
geneSymbol: TOR2A
name: Prosalusin (Torsin family 2 member A) (Torsin-2A) [Cleaved into: Salusin-alpha; Salusin-beta]
length: 242
go: ENSG00000160404;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12910263}.
sequence:

opentargets:
extracellular region [GO:0005576]; ATP binding [GO:0005524]; hormone activity [GO:0005179]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; killing of cells of other organism [GO:0031640]; membrane disruption in other organism [GO:0051673]; positive regulation of calcium ion transmembrane transport [GO:1904427]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; vasopressin secretion [GO:0030103]; water homeostasis [GO:0030104]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=4; IsoId=Q8N2E6-1; Sequence=Displayed; Note=Salusins -alpha and -beta peptides are derived from isoform 4.; Name=1; IsoId=Q5JU69-1; Sequence=External; Name=2; IsoId=Q5JU69-2; Sequence=External; Note=No experimental confirmation available.; Name=3; IsoId=Q5JU69-5; Sequence=External; Note=No experimental confirmation available.; 


uniprotID: Q12974
geneSymbol: PTP4A2
reactome: R-HSA-8873719;
pdb: 5K22;5K23;5K25;
length: 167
go: ENSG00000184007;
location: SUBCELLULAR LOCATION: Cell membrane. Early endosome. Cytoplasm.
name:
Protein tyrosine phosphatase type IVA 2 (EC 3.1.3.48) (HU-PP-1) (OV-1) (PTP(CAAXII)) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2)

sequence:
MNRPAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRDTNGHCCVQ

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725]; post-translational protein modification [GO:0043687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Ptp-IV1a, Ptp-IV1b; IsoId=Q12974-1; Sequence=Displayed; Name=2; Synonyms=PTP4Ar; IsoId=Q12974-2; Sequence=VSP_014404, VSP_014405; Name=3; IsoId=Q12974-3; Sequence=VSP_044813; Note=No experimental confirmation available.; Name=4; IsoId=Q12974-4; Sequence=VSP_055056; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: O14798
geneSymbol: TNFRSF10C
reactome: R-HSA-6803211;
length: 259
go: ENSG00000173535;
snps: rs12550828 rs9644063
location: SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
name:
Tumor necrosis factor receptor superfamily member 10C (Antagonist decoy receptor for TRAIL/Apo-2L) (Decoy TRAIL receptor without death domain) (Decoy receptor 1) (DcR1) (Lymphocyte inhibitor of TRAIL) (TNF-related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (TRAIL receptor without an intracellular domain) (CD antigen CD263)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; cell surface [GO:0009986]; plasma membrane [GO:0005886]; TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888]; positive regulation of apoptotic process [GO:0043065]; regulation of apoptotic process [GO:0042981]; TRAIL-activated apoptotic signaling pathway [GO:0036462]


uniprotID: Q9UBN6
geneSymbol: TNFRSF10D
reactome: R-HSA-202733;R-HSA-6803211;R-HSA-75158;
length: 386
snps: rs11135703 rs55636833 rs1133782 rs34622674
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Tumor necrosis factor receptor superfamily member 10D (Decoy receptor 2) (DcR2) (TNF-related apoptosis-inducing ligand receptor 4) (TRAIL receptor 4) (TRAIL-R4) (TRAIL receptor with a truncated death domain) (CD antigen CD264)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; TRAIL binding [GO:0045569]; transmembrane signaling receptor activity [GO:0004888]; apoptotic process [GO:0006915]; cell surface receptor signaling pathway [GO:0007166]; leukocyte migration [GO:0050900]; negative regulation of apoptotic process [GO:0043066]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]


uniprotID: P08582
geneSymbol: MELTF
reactome: R-HSA-163125;R-HSA-381426;R-HSA-8957275;
name: Melanotransferrin (Melanoma-associated antigen p97) (CD antigen CD228)
length: 738
go: ENSG00000163975;
snps: rs2276790 rs17129219
location: SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor.
sequence:

opentargets:
anchored component of plasma membrane [GO:0046658]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; iron ion binding [GO:0005506]; cellular protein metabolic process [GO:0044267]; iron ion homeostasis [GO:0055072]; iron ion import [GO:0097286]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of extracellular matrix disassembly [GO:0090091]; positive regulation of plasminogen activation [GO:0010756]; post-translational protein modification [GO:0043687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P08582-1; Sequence=Displayed; Name=2; IsoId=P08582-2; Sequence=VSP_006557, VSP_006558; Note=No experimental confirmation available.; 


uniprotID: Q7Z2T5
geneSymbol: TRMT1L
name: TRMT1-like protein (EC 2.1.1.-)
length: 733
go: ENSG00000121486;
sequence:

opentargets:
mitochondrion [GO:0005739]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; tRNA (guanine-N2-)-methyltransferase activity [GO:0004809]; tRNA binding [GO:0000049]; behavior [GO:0007610]; tRNA N2-guanine methylation [GO:0002940]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z2T5-1; Sequence=Displayed; Name=2; IsoId=Q7Z2T5-2; Sequence=VSP_031042, VSP_031043; Note=No experimental confirmation available.; 


uniprotID: P03979
geneSymbol: TRGV3
name: T cell receptor gamma variable 3 (T-cell receptor gamma V-gamma-1.1 region) (Fragment)
length: 118
go: ENSG00000211699;
sequence:
MRWALLVLLAFLSPASQKSSNLEGRTKSVTRQTGSSAEITCDLTVTNTFYIHWYLHQEGKAPQRLLYYDVSTARDVLESGLSPGKYYTHTPRRWSWILRLQNLIENDSGVYYCATWDR

opentargets:
plasma membrane [GO:0005886]; MHC protein binding [GO:0042287]; peptide antigen binding [GO:0042605]; immune response [GO:0006955]


uniprotID: Q15643
geneSymbol: TRIP11
reactome: R-HSA-5620924;R-HSA-6811438;
length: 1979
go: ENSG00000100815;
name:
Thyroid receptor-interacting protein 11 (TR-interacting protein 11) (TRIP-11) (Clonal evolution-related gene on chromosome 14 protein) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230)

sequence:

opentargets:
cilium [GO:0005929]; cis-Golgi network [GO:0005801]; cytoskeleton [GO:0005856]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; inner acrosomal membrane [GO:0002079]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; outer acrosomal membrane [GO:0002081]; transport vesicle [GO:0030133]; transcription coactivator activity [GO:0003713]; chondrocyte differentiation involved in endochondral bone morphogenesis [GO:0003413]; Golgi organization [GO:0007030]; inner ear receptor cell stereocilium organization [GO:0060122]; intraciliary transport involved in cilium assembly [GO:0035735]; protein glycosylation [GO:0006486]; transcription by RNA polymerase II [GO:0006366]; ventricular septum development [GO:0003281]

snps:
rs17127898 rs2273186 rs34699762 rs34967261 rs34805848 rs4619320 rs12884523 rs34839498 rs35007347 rs2273183 rs11851376 rs1051340 rs141259390 

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10189370}; Peripheral membrane protein {ECO:0000269|PubMed:10189370}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10189370}. Note=Associates with the ends of centrosome-nucleated microtubules.


uniprotID: Q9UBN4
geneSymbol: TRPC4
reactome: R-HSA-3295583;R-HSA-418890;
name: Short transient receptor potential channel 4 (TrpC4) (Trp-related protein 4) (hTrp-4) (hTrp4)
length: 977
go: ENSG00000133107;
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; caveola [GO:0005901]; cell surface [GO:0009986]; cortical cytoskeleton [GO:0030863]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion import [GO:0070509]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; gamma-aminobutyric acid secretion [GO:0014051]; manganese ion transport [GO:0006828]; oligodendrocyte differentiation [GO:0048709]; regulation of cytosolic calcium ion concentration [GO:0051480]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=Alpha; IsoId=Q9UBN4-1; Sequence=Displayed; Name=Beta; IsoId=Q9UBN4-2; Sequence=VSP_006569; Name=Delta; IsoId=Q9UBN4-3; Sequence=VSP_006568; Name=Gamma; IsoId=Q9UBN4-4; Sequence=VSP_006567, VSP_006569; Name=Epsilon; IsoId=Q9UBN4-5; Sequence=VSP_041262; Name=Zeta; IsoId=Q9UBN4-6; Sequence=VSP_041439; Name=Eta; IsoId=Q9UBN4-7; Sequence=VSP_047747, VSP_047748; 

location:
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.


uniprotID: Q9UL62
geneSymbol: TRPC5
reactome: R-HSA-3295583;R-HSA-418890;
length: 973
go: ENSG00000072315;
snps: rs36047478
name:
Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (TRP-5) (hTRP-5) (hTRP5)

sequence:

opentargets:
calcium channel complex [GO:0034704]; cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; growth cone [GO:0030426]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; calcium ion transport [GO:0006816]; manganese ion transport [GO:0006828]; negative regulation of dendrite morphogenesis [GO:0050774]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; positive regulation of axon extension [GO:0045773]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of membrane hyperpolarization [GO:1902630]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16284075}; Multi-pass membrane protein {ECO:0000269|PubMed:16284075}.


uniprotID: Q9Y210
geneSymbol: TRPC6
reactome: R-HSA-114508;R-HSA-139853;R-HSA-3295583;R-HSA-418890;
pdb: 5YX9;
name: Short transient receptor potential channel 6 (TrpC6) (Transient receptor protein 6) (TRP-6)
length: 931
go: ENSG00000137672;
sequence:

opentargets:
cation channel complex [GO:0034703]; cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; slit diaphragm [GO:0036057]; actin binding [GO:0003779]; actinin binding [GO:0042805]; ATPase binding [GO:0051117]; calcium channel activity [GO:0005262]; cation channel activity [GO:0005261]; clathrin binding [GO:0030276]; inositol 1,4,5 trisphosphate binding [GO:0070679]; protein homodimerization activity [GO:0042803]; store-operated calcium channel activity [GO:0015279]; aging [GO:0007568]; calcium ion transmembrane transport [GO:0070588]; cation transport [GO:0006812]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to hypoxia [GO:0071456]; manganese ion transport [GO:0006828]; negative regulation of dendrite morphogenesis [GO:0050774]; neuron differentiation [GO:0030182]; platelet activation [GO:0030168]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]

snps:
rs3802829 rs121434390 rs146776939 rs121434391 rs35857503 rs779430565 rs121434392 rs777715086 rs36111323 rs771594597 rs121434394 rs121434395 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y210-1; Sequence=Displayed; Name=2; IsoId=Q9Y210-2; Sequence=VSP_006572; Name=3; IsoId=Q9Y210-3; Sequence=VSP_006573; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23291369, ECO:0000269|PubMed:26892346}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q9HCX4
geneSymbol: TRPC7
reactome: R-HSA-114508;R-HSA-139853;R-HSA-3295583;R-HSA-418890;
name: Short transient receptor potential channel 7 (TrpC7) (Transient receptor protein 7) (TRP-7) (hTRP7)
length: 862
go: ENSG00000069018;
sequence:

opentargets:
cation channel complex [GO:0034703]; cis-Golgi network [GO:0005801]; integral component of plasma membrane [GO:0005887]; nuclear envelope [GO:0005635]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium channel activity [GO:0005262]; inositol 1,4,5 trisphosphate binding [GO:0070679]; store-operated calcium channel activity [GO:0015279]; calcium ion transmembrane transport [GO:0070588]; manganese ion transport [GO:0006828]; platelet activation [GO:0030168]; regulation of cytosolic calcium ion concentration [GO:0051480]; single fertilization [GO:0007338]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9HCX4-1; Sequence=Displayed; Name=2; IsoId=Q9HCX4-2; Sequence=VSP_043035; Note=No experimental confirmation available.; Name=3; IsoId=Q9HCX4-3; Sequence=VSP_044897; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21402151}; Multi-pass membrane protein {ECO:0000269|PubMed:21402151}. Nucleus envelope {ECO:0000269|PubMed:21402151}.


uniprotID: Q969D9
geneSymbol: TSLP
reactome: R-HSA-1266695;
pdb: 5J11;5J12;5J13;
name: Thymic stromal lymphopoietin
length: 159
go: ENSG00000145777;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11418668}.
sequence:
MFPFALLYVLSVSFRKIFILQLVGLVLTYDFTNCDFEKIKAAYLSTISKDLITYMSGTKSTEFNNTVSCSNRPHCLTEIQSLTFNPTAGCASLAKEMFAMKTKAALAIWCPGYSETQINATQAMKKRRKRKVTTNKCLEQVSQLQGLWRRFNRPLLKQQ

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; cytokine activity [GO:0005125]; interleukin-7 receptor binding [GO:0005139]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; interleukin-7-mediated signaling pathway [GO:0038111]; negative regulation of apoptotic process [GO:0043066]; negative regulation of growth of symbiont on or near host surface [GO:0044140]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemokine (C-C motif) ligand 1 production [GO:0071654]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of granulocyte colony-stimulating factor production [GO:0071657]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of interleukin-5 secretion [GO:2000664]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell activation [GO:0033005]; positive regulation of STAT cascade [GO:1904894]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=lfTSLP; IsoId=Q969D9-1; Sequence=Displayed; Name=2; Synonyms=sfTSLP; IsoId=Q969D9-2; Sequence=VSP_057462; 


uniprotID: A6NKD2
geneSymbol: TSPY2
name: Testis-specific Y-encoded protein 2 (Testis-specific Y-encoded protein Q1)
length: 308
sequence:


uniprotID: P0CW00
geneSymbol: TSPY8
name: Testis-specific Y-encoded protein 8
length: 308
sequence:


uniprotID: Q9Y5U2
geneSymbol: TSSC4
length: 329
go: ENSG00000184281;
snps: rs2234278 rs1008265 rs2234280 rs2234281 rs2234283
name:
Protein TSSC4 (Tumor-suppressing STF cDNA 4 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5U2-1; Sequence=Displayed; Name=2; IsoId=Q9Y5U2-2; Sequence=VSP_016561; 


uniprotID: Q9NX07
geneSymbol: TRNAU1AP
pdb: 2DHG;2DIV;
name: tRNA selenocysteine 1-associated protein 1 (SECp43) (tRNA selenocysteine-associated protein 1)
length: 287
go: ENSG00000180098;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]; selenocysteine incorporation [GO:0001514]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NX07-1; Sequence=Displayed; Name=2; IsoId=Q9NX07-2; Sequence=VSP_028130; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Abundant in the nucleus. {ECO:0000250}.


uniprotID: Q96NG3
geneSymbol: TTC25
name: Tetratricopeptide repeat protein 25 (TPR repeat protein 25)
length: 672
go: ENSG00000204815;
opentargets: cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]
snps: rs34516580 rs35516909
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27486780}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96NG3-1; Sequence=Displayed; Name=2; IsoId=Q96NG3-2; Sequence=VSP_024548, VSP_024549; Note=No experimental confirmation available.; 


uniprotID: Q2M3C6
geneSymbol: TMEM266
name: Transmembrane protein 266
length: 531
go: ENSG00000169758;
opentargets: cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
snps: rs937732 rs937733
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2M3C6-1; Sequence=Displayed; Note=Gene prediction based on EST data.; Name=2; IsoId=Q2M3C6-2; Sequence=VSP_022108; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:22020278}; Multi-pass membrane protein {ECO:0000269|PubMed:22020278}.


uniprotID: Q9NS93
geneSymbol: TM7SF3
name: Transmembrane 7 superfamily member 3 (Seven span transmembrane protein)
length: 570
go: ENSG00000064115;
snps: rs34735713 rs10771314
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cellular response to unfolded protein [GO:0034620]; negative regulation of programmed cell death [GO:0043069]; positive regulation of insulin secretion [GO:0032024]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10828615}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: A5PLN9
geneSymbol: TRAPPC13
reactome: R-HSA-8876198;
name: Trafficking protein particle complex subunit 13
length: 417
go: ENSG00000113597;
opentargets: cytosol [GO:0005829]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=A5PLN9-1; Sequence=Displayed; Name=2; IsoId=A5PLN9-2; Sequence=VSP_038356; Name=3; IsoId=A5PLN9-4; Sequence=VSP_038356, VSP_038359; Name=4; IsoId=A5PLN9-5; Sequence=VSP_038359; Name=5; IsoId=A5PLN9-7; Sequence=VSP_038356, VSP_038357, VSP_038358; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q6P7N7
geneSymbol: TMEM81
name: Transmembrane protein 81
length: 255
go: ENSG00000174529;
opentargets: integral component of membrane [GO:0016021]
snps: rs4951168 rs16855059
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9NS68
geneSymbol: TNFRSF19
name: Tumor necrosis factor receptor superfamily member 19 (TRADE) (Toxicity and JNK inducer)
length: 423
go: ENSG00000127863;
snps: rs9550987 rs61756242 rs3751362
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; tumor necrosis factor-activated receptor activity [GO:0005031]; apoptotic process [GO:0006915]; hair follicle development [GO:0001942]; JNK cascade [GO:0007254]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TAJ-alpha, TRADEalpha; IsoId=Q9NS68-1; Sequence=Displayed; Name=2; Synonyms=TRADEbeta; IsoId=Q9NS68-2; Sequence=VSP_006512; Name=3; IsoId=Q9NS68-3; Sequence=VSP_044886, VSP_006512; Note=No experimental confirmation available.; 


uniprotID: O15405
geneSymbol: TOX3
length: 576
go: ENSG00000103460;
snps: rs16951186 rs13332816
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein)

sequence:

opentargets:
nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; estrogen response element binding [GO:0034056]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of apoptotic process [GO:0042981]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15405-1; Sequence=Displayed; Name=2; IsoId=O15405-2; Sequence=VSP_043095, VSP_043096; Note=No experimental confirmation available.; 


uniprotID: B3SHH9
geneSymbol: TMEM114
name: Transmembrane protein 114
length: 223
go: ENSG00000232258;
snps: rs1048548807 rs141472774
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255}.
sequence:

opentargets:
apical plasma membrane [GO:0016324]; apicolateral plasma membrane [GO:0016327]; integral component of membrane [GO:0016021]


uniprotID: Q969S6
geneSymbol: TMEM203
name: Transmembrane protein 203
length: 136
go: ENSG00000187713;
sequence:
MLFSLRELVQWLGFATFEIFVHLLALLVFSVLLALRVDGLVPGLSWWNVFVPFFAADGLSTYFTTIVSVRLFQDGEKRLAVLRLFWVLTVLSLKFVFEMLLCQKLAEQTRELWFGLITSPLFILLQLLMIRACRVN

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; cellular calcium ion homeostasis [GO:0006874]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25996873}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q5TGY1
geneSymbol: TMCO4
name: Transmembrane and coiled-coil domain-containing protein 4
length: 634
go: ENSG00000162542;
opentargets: integral component of membrane [GO:0016021]
snps: rs10917536 rs4515815
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TGY1-1; Sequence=Displayed; Name=2; IsoId=Q5TGY1-2; Sequence=VSP_028242; Note=No experimental confirmation available.; 


uniprotID: Q15363
geneSymbol: TMED2
reactome: R-HSA-1912420;R-HSA-204005;R-HSA-5694530;R-HSA-6807878;R-HSA-6811434;
pdb: 5AZW;
length: 201
go: ENSG00000086598;
name:
Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)

sequence:

opentargets:
COPI-coated vesicle [GO:0030137]; COPI-coated vesicle membrane [GO:0030663]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; transport vesicle [GO:0030133]; zymogen granule membrane [GO:0042589]; cargo loading into vesicle [GO:0035459]; COPI coating of Golgi vesicle [GO:0048205]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; heart looping [GO:0001947]; intracellular protein transport [GO:0006886]; labyrinthine layer blood vessel development [GO:0060716]; maternal placenta development [GO:0001893]; multicellular organism growth [GO:0035264]; negative regulation of GTPase activity [GO:0034260]; neural tube closure [GO:0001843]; positive regulation of gene expression [GO:0010628]; post-anal tail morphogenesis [GO:0036342]; protein localization to plasma membrane [GO:0072659]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; somite rostral/caudal axis specification [GO:0032525]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:12237308}.


uniprotID: Q8IV31
geneSymbol: TMEM139
name: Transmembrane protein 139
length: 216
go: ENSG00000178826;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q7Z7H5
geneSymbol: TMED4
length: 227
go: ENSG00000158604;
name:
Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3)

sequence:

opentargets:
COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z7H5-1; Sequence=Displayed; Name=2; IsoId=Q7Z7H5-2; Sequence=VSP_035698; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z7H5-3; Sequence=VSP_035699, VSP_035700; 


uniprotID: Q9Y5R8
geneSymbol: TRAPPC1
reactome: R-HSA-204005;R-HSA-6798695;R-HSA-8876198;
name: Trafficking protein particle complex subunit 1 (BET5 homolog) (Multiple myeloma protein 2) (MUM-2)
length: 145
go: ENSG00000170043;
drug: DB08342;
sequence:
MTVHNLYLFDRNGVCLHYSEWHRKKQAGIPKEEEYKLMYGMLFSIRSFVSKMSPLDMKDGFLAFQTSRYKLHYYETPTGIKVVMNTDLGVGPIRDVLHHIYSALYVELVVKNPLCPLGQTVQSELFRSRLDSYVRSLPFFSARAG

opentargets:
azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; neutrophil degranulation [GO:0043312]

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.


uniprotID: Q07011
geneSymbol: TNFRSF9
reactome: R-HSA-5669034;
pdb: 6BWV;6CPR;6CU0;
length: 255
go: ENSG00000049249;
snps: rs9657963 rs9657965 rs9657979 rs776878260
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Tumor necrosis factor receptor superfamily member 9 (4-1BB ligand receptor) (CDw137) (T-cell antigen 4-1BB homolog) (T-cell antigen ILA) (CD antigen CD137)

sequence:

opentargets:
external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; apoptotic process [GO:0006915]; negative regulation of cell proliferation [GO:0008285]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: Q6NT04
geneSymbol: TIGD7
name: Tigger transposable element-derived protein 7
length: 549
go: ENSG00000140993;
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NT04-1; Sequence=Displayed; Name=2; IsoId=Q6NT04-2; Sequence=VSP_022453; 


uniprotID: A0A1B0GTI8
geneSymbol: TMEM272
name: Transmembrane protein 272
length: 121
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:
MVSLLLYDSTRMRRLLSKAVVIDDDDDDEYPWRQNAHRYYIHLLLSLFLFLWFILGNYWVFSVYLPDFLPPFQQPQDYCDKTLYLFAVGVLALSHTVLVLLLLCSGCVYLCSRWRLAADED


uniprotID: O75888
geneSymbol: TNFSF13
reactome: R-HSA-450520;R-HSA-5669034;
pdb: 4ZCH;
length: 250
go: ENSG00000161955;
snps: rs11552708 rs3803800
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11571266}.
name:
Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; immune response [GO:0006955]; positive regulation of cell proliferation [GO:0008284]; positive regulation of isotype switching to IgA isotypes [GO:0048298]; regulation of mRNA stability [GO:0043488]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=Alpha; IsoId=O75888-1; Sequence=Displayed; Name=Beta; IsoId=O75888-2; Sequence=VSP_006450; Name=Gamma; IsoId=O75888-3; Sequence=VSP_006451; Name=4; IsoId=O75888-4; Sequence=VSP_043154; Note=No experimental confirmation available.; Name=TWE-PRIL; Synonyms=TNFSF12-TNFSF13; IsoId=O43508-2; Sequence=External; Note=Based on a readthrough transcript which may produce a TWE-PRIL (TNFSF12-TNFSF13) fusion protein. Expressed at protein level in primary T-lymphocytes and monocytic cell lines.; Name=5; IsoId=O75888-5; Sequence=VSP_046725, VSP_046726; Note=Gene prediction based on EST data.; 


uniprotID: Q9BTV4
geneSymbol: TMEM43
name: Transmembrane protein 43 (Protein LUMA)
length: 400
go: ENSG00000170876;
snps: rs397514044 rs144811578 rs4685076 rs2340917 rs35924492 rs11924644 rs63750743
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; integral component of nuclear inner membrane [GO:0005639]; protein self-association [GO:0043621]; nuclear membrane organization [GO:0071763]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Nucleus inner membrane; Multi-pass membrane protein. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). {ECO:0000250}.


uniprotID: Q9H497
geneSymbol: TOR3A
name: Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A)
length: 397
go: ENSG00000186283;
snps: rs2296377
location: SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum lumen.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=ADIR1; IsoId=Q9H497-1; Sequence=Displayed; Name=2; Synonyms=ADIR2; IsoId=Q9H497-2; Sequence=VSP_017666, VSP_017667; Name=3; IsoId=Q9H497-3; Sequence=VSP_017665; 


uniprotID: Q8NE00
geneSymbol: TMEM104
name: Transmembrane protein 104
length: 496
go: ENSG00000109066;
opentargets: integral component of membrane [GO:0016021]
snps: rs2016126 rs3803784
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NE00-1; Sequence=Displayed; Name=2; IsoId=Q8NE00-2; Sequence=VSP_021199, VSP_021200; Note=No experimental confirmation available.; 


uniprotID: P41273
geneSymbol: TNFSF9
reactome: R-HSA-5669034;
pdb: 2X29;6BWV;6CPR;6CU0;6D3N;
name: Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)
length: 254
go: ENSG00000125657;
snps: rs442511
location: SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
sequence:

opentargets:
extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; cell-cell signaling [GO:0007267]; immune response [GO:0006955]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of cytotoxic T cell differentiation [GO:0045585]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: Q9H330
geneSymbol: TMEM245
name: Transmembrane protein 245 (Protein CG-2)
length: 879
go: ENSG00000106771;
opentargets: integral component of membrane [GO:0016021]
snps: rs12001627 rs2271877 rs3750455
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=2; IsoId=Q9H330-2; Sequence=Displayed; Name=3; IsoId=Q9H330-3; Sequence=VSP_014680; Note=No experimental confirmation available.; Name=4; IsoId=Q9H330-4; Sequence=VSP_059402, VSP_059403, VSP_059404; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}; 


uniprotID: A2RRL7
geneSymbol: TMEM213
name: Transmembrane protein 213
length: 107
go: ENSG00000214128;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MQRLPAATRATLILSLAFASLHSACSAEASSSNSSSLTAHHPDPGTLEQCLNVDFCPQAARCCRTGVDEYGWIAAAVGWSLWFLTLILLCVDKLMKLTPDEPKDLQA

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=A2RRL7-1; Sequence=Displayed; Note=Gene prediction based on EST data.; Name=2; IsoId=A2RRL7-2; Sequence=VSP_039555; Note=Gene prediction based on EST data.; Name=3; IsoId=A2RRL7-3; Sequence=VSP_039556; Note=No experimental confirmation available.; Name=4; IsoId=A2RRL7-4; Sequence=VSP_039557; Note=Gene prediction based on EST data.; 


uniprotID: Q13470
geneSymbol: TNK1
name: Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)
length: 666
go: ENSG00000174292;
snps: rs55939858 rs55641092 rs36046975 rs56093628 rs6503018
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; cell differentiation [GO:0030154]; negative regulation of cell growth [GO:0030308]; negative regulation of Ras protein signal transduction [GO:0046580]; peptidyl-tyrosine autophosphorylation [GO:0038083]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cell proliferation [GO:0042127]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:8632913}; IsoId=Q13470-1; Sequence=Displayed; Name=2 {ECO:0000305}; IsoId=Q13470-2; Sequence=VSP_051663; Note=No experimental confirmation available. {ECO:0000244|PubMed:18691976, ECO:0000244|PubMed:19369195}; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10873601}. Membrane {ECO:0000269|PubMed:10873601}; Peripheral membrane protein {ECO:0000269|PubMed:10873601}.


uniprotID: Q8TBM7
geneSymbol: TMEM254
name: Transmembrane protein 254
length: 123
go: ENSG00000133678;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MATAAGATYFQRGSLFWFTVITLSFGYYTWVVFWPQSIPYQNLGPLGPFTQYLVDHHHTLLCNGYWLAWLIHVGESLYAIVLCKHKGITSGRAQLLWFLQTFFFGIASLTILIAYKRKRQKQT

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TBM7-1; Sequence=Displayed; Name=2; IsoId=Q8TBM7-2; Sequence=VSP_047062; Note=Gene prediction based on EST data.; Name=3; IsoId=Q8TBM7-3; Sequence=VSP_047063; Note=Gene prediction based on EST data.; 


uniprotID: Q96HE8
geneSymbol: TMEM80
name: Transmembrane protein 80
length: 216
go: ENSG00000177042;
sequence:

opentargets:
ciliary transition zone [GO:0035869]; integral component of membrane [GO:0016021]; non-motile cilium assembly [GO:1905515]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=2;  Name=1; IsoId=Q96HE8-1; Sequence=Displayed; Name=2; IsoId=Q96HE8-2; Sequence=VSP_059531, VSP_059532; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9D3H0}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250|UniProtKB:Q9D3H0}.


uniprotID: Q9Y3A6
geneSymbol: TMED5
reactome: R-HSA-3238698;
name: Transmembrane emp24 domain-containing protein 5 (p24 family protein gamma-2) (p24gamma2) (p28)
length: 229
go: ENSG00000117500;
snps: rs1060622
sequence:

opentargets:
cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; Golgi ribbon formation [GO:0090161]; intracellular protein transport [GO:0006886]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3A6-1; Sequence=Displayed; Name=2; IsoId=Q9Y3A6-2; Sequence=VSP_046365; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269|PubMed:19948005}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269|PubMed:19948005}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19948005}; Single-pass type I membrane protein {ECO:0000269|PubMed:19948005}. Note=Probably cycles between compartments of the early secretatory pathway.


uniprotID: Q96HV5
geneSymbol: TMEM41A
name: Transmembrane protein 41A
length: 264
go: ENSG00000163900;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q69YG0
geneSymbol: TMEM42
name: Transmembrane protein 42
length: 159
go: ENSG00000169964;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MAERPGPPGGAVSATAYPDTPAEFPPHLQAGAMRRRFWGVFNCLCAGAFGALAAASAKLAFGSEVSMGLCVLGIIVMASTNSLMWTFFSRGLSFSMSSAIASVTVTFSNILSSAFLGYVLYGECQEVLWWGGVFLILCGLTLIHRKLPPTWKPLPHKQQ


uniprotID: O43557
geneSymbol: TNFSF14
reactome: R-HSA-5668541;R-HSA-5669034;R-HSA-5676594;
pdb: 4EN0;4J6G;4KG8;4KGG;4KGQ;4RSU;
length: 240
go: ENSG00000125735;
snps: rs2291667 rs17851606 rs344560
name:
Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; cytokine activity [GO:0005125]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell costimulation [GO:0031295]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43557-1; Sequence=Displayed; Name=2; Synonyms=LIGHT delta-TM; IsoId=O43557-2; Sequence=VSP_006452; 

location:
SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.


uniprotID: P45378
geneSymbol: TNNT3
reactome: R-HSA-390522;
name: Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)
length: 269
go: ENSG00000130595;
snps: rs121434638
sequence:

opentargets:
cytosol [GO:0005829]; troponin complex [GO:0005861]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013]; cardiac muscle contraction [GO:0060048]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; regulation of ATPase activity [GO:0043462]; regulation of striated muscle contraction [GO:0006942]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Tnt1; IsoId=P45378-1; Sequence=Displayed; Name=2; Synonyms=Tnt3; IsoId=P45378-2; Sequence=VSP_007914; Name=3; Synonyms=Tnt1f; IsoId=P45378-3; Sequence=VSP_007915; Name=4; Synonyms=Tnt3f; IsoId=P45378-4; Sequence=VSP_007914, VSP_007915, VSP_007916; Name=5; Synonyms=Tnt3f*; IsoId=P45378-5; Sequence=VSP_009121; Note=Minor isoform detected in approximately 1% of cDNA clones.; Name=6; IsoId=P45378-6; Sequence=VSP_034964; Name=7; IsoId=P45378-7; Sequence=VSP_007914, VSP_007915; 


uniprotID: Q9BSE2
geneSymbol: TMEM79
name: Transmembrane protein 79 (Mattrin)
length: 394
go: ENSG00000163472;
snps: rs6684514
sequence:

opentargets:
integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; trans-Golgi network membrane [GO:0032588]; identical protein binding [GO:0042802]; cornification [GO:0070268]; cuticle development [GO:0042335]; epithelial cell maturation [GO:0002070]; establishment of skin barrier [GO:0061436]; hair follicle morphogenesis [GO:0031069]; positive regulation of epidermis development [GO:0045684]; regulated exocytosis [GO:0045055]

location:
SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Colocalized with TGOLN2 in the trans-Golgi network. Colocalized with LAMP1 in the lysosome (By similarity). {ECO:0000250}.


uniprotID: P09493
geneSymbol: TPM1
reactome: R-HSA-390522;R-HSA-445355;
pdb: 3MUD;5KHT;
name: Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
length: 284
go: ENSG00000140416;
snps: rs104894501 rs104894505 rs199476306 rs104894503 rs104894502 rs104894502 rs199476315 rs199476319
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; bleb [GO:0032059]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; muscle thin filament tropomyosin [GO:0005862]; ruffle membrane [GO:0032587]; sarcomere [GO:0030017]; stress fiber [GO:0001725]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; cardiac muscle contraction [GO:0060048]; cellular response to reactive oxygen species [GO:0034614]; cytoskeleton organization [GO:0007010]; in utero embryonic development [GO:0001701]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; negative regulation of cell migration [GO:0030336]; negative regulation of vascular associated smooth muscle cell migration [GO:1904753]; negative regulation of vascular smooth muscle cell proliferation [GO:1904706]; positive regulation of ATPase activity [GO:0032781]; positive regulation of cell adhesion [GO:0045785]; positive regulation of heart rate by epinephrine [GO:0003065]; positive regulation of stress fiber assembly [GO:0051496]; regulation of cell shape [GO:0008360]; regulation of heart contraction [GO:0008016]; regulation of muscle contraction [GO:0006937]; ruffle organization [GO:0031529]; sarcomere organization [GO:0045214]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]; wound healing [GO:0042060]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=10;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Skeletal muscle, TPM1alpha; IsoId=P09493-1; Sequence=Displayed; Name=2; Synonyms=Smooth muscle; IsoId=P09493-2; Sequence=VSP_006576, VSP_006578, VSP_006579; Note=Incomplete sequence. {ECO:0000244|PubMed:24275569}; Name=3; Synonyms=Fibroblast, TM3; IsoId=P09493-3; Sequence=VSP_006577, VSP_006579; Name=4; IsoId=P09493-4; Sequence=VSP_006577; Name=5; IsoId=P09493-5; Sequence=VSP_017498, VSP_017499; Name=6; Synonyms=10, TPM1kappa; IsoId=P09493-6; Sequence=VSP_036064; Name=7; IsoId=P09493-7; Sequence=VSP_036064, VSP_006579; Note=No experimental confirmation available.; Name=8; IsoId=P09493-8; Sequence=VSP_047297, VSP_047298, VSP_047299, VSP_047300, VSP_006579; Note=Gene prediction based on EST data. {ECO:0000244|PubMed:19608861}; Name=9; IsoId=P09493-9; Sequence=VSP_006579; Note=Gene prediction based on EST data.; Name=10; IsoId=P09493-10; Sequence=VSP_047299, VSP_047300, VSP_047301; Note=No experimental confirmation available. {ECO:0000244|PubMed:19608861}; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04692}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P04692}.


uniprotID: Q99595
geneSymbol: TIMM17A
reactome: R-HSA-1268020;
length: 171
go: ENSG00000134375;
snps: rs4648
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
name:
Mitochondrial import inner membrane translocase subunit Tim17-A (Inner membrane preprotein translocase Tim17a)

sequence:
MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGVNHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAILAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAEDPSQLPSTQLPSSPFGDYRQYQ

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; positive regulation of protein processing [GO:0010954]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]


uniprotID: Q5JXX7
geneSymbol: TMEM31
name: Transmembrane protein 31
length: 168
go: ENSG00000179363;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MRLTEKSEGEQQLKPNNSNAPNEDQEEEIQQSEQHTPARQRTQRADTQPSRCRLPSRRTPTTSSDRTINLLEVLPWPTEWIFNPYRLPALFELYPEFLLVFKEAFHDISHCLKAQMEKIGLPIILHLFALSTLYFYKFFLPTILSLSFFILLVLLLLLFIIVFILIFF


uniprotID: Q9NZ63
geneSymbol: C9orf78
name: Telomere length and silencing protein 1 homolog (Hepatocellular carcinoma-associated antigen 59)
length: 289
go: ENSG00000136819;
snps: rs1237745
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; regulation of mRNA splicing, via spliceosome [GO:0048024]


uniprotID: O95150
geneSymbol: TNFSF15
reactome: R-HSA-5669034;
pdb: 2O0O;2QE3;2RE9;2RJK;2RJL;3K51;3MI8;
length: 251
go: ENSG00000181634;
snps: rs16931745
name:
Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form]

sequence:

opentargets:
extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic process [GO:0006915]; cytokine metabolic process [GO:0042107]; immune response [GO:0006955]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TL1A, VEGI-251; IsoId=O95150-1; Sequence=Displayed; Name=2; Synonyms=VEGI-192; IsoId=O95150-2; Sequence=VSP_033492; Name=3; Synonyms=VEGI-174; IsoId=O95150-3; Sequence=VSP_033493, VSP_033494; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}; Single-pass type II membrane protein {ECO:0000305|PubMed:11911831, ECO:0000305|PubMed:11923219}.; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 15, secreted form: Secreted.


uniprotID: Q8NHX9
geneSymbol: TPCN2
reactome: R-HSA-2672351;
name: Two pore calcium channel protein 2 (Voltage-dependent calcium channel protein TPC2)
length: 752
go: ENSG00000162341;
snps: rs3750965 rs35264875 rs2376558 rs3829241
sequence:

opentargets:
endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; identical protein binding [GO:0042802]; NAADP-sensitive calcium-release channel activity [GO:0072345]; protein kinase binding [GO:0019901]; voltage-gated calcium channel activity [GO:0005245]; calcium-mediated signaling [GO:0019722]; cellular calcium ion homeostasis [GO:0006874]; ion transmembrane transport [GO:0034220]; lysosome organization [GO:0007040]; regulation of autophagy [GO:0010506]; regulation of ion transmembrane transport [GO:0034765]; response to vitamin D [GO:0033280]; smooth muscle contraction [GO:0006939]

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Only the acidic lysosomal fraction is sensitive to NAADP. {ECO:0000250}.


uniprotID: Q3LXA3
geneSymbol: TKFC
reactome: R-HSA-168928;R-HSA-70350;
length: 575
go: ENSG00000149476;
snps: rs2260655 rs35723406
name:
Triokinase/FMN cyclase (Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)) [Includes: ATP-dependent dihydroxyacetone kinase (DHA kinase) (EC 2.7.1.28) (EC 2.7.1.29) (Glycerone kinase) (Triokinase) (Triose kinase); FAD-AMP lyase (cyclizing) (EC 4.6.1.15) (FAD-AMP lyase (cyclic FMN forming)) (FMN cyclase)]

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ATP binding [GO:0005524]; FAD-AMP lyase (cyclizing) activity [GO:0034012]; glycerone kinase activity [GO:0004371]; metal ion binding [GO:0046872]; triokinase activity [GO:0050354]; carbohydrate phosphorylation [GO:0046835]; cellular carbohydrate metabolic process [GO:0044262]; fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate [GO:0061624]; glycerol catabolic process [GO:0019563]; innate immune response [GO:0045087]; negative regulation of MDA-5 signaling pathway [GO:0039534]; regulation of innate immune response [GO:0045088]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q3LXA3-1; Sequence=Displayed; Name=2; IsoId=Q3LXA3-2; Sequence=VSP_057181; Note=Inactive as DHA kinase and FMN cyclase.; 


uniprotID: Q969P6
geneSymbol: TOP1MT
name: DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.99.1.2)
length: 601
go: ENSG00000184428;
drug: DB00762;DB01030;
snps: rs11544484 rs2293925
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11526219}.
sequence:

opentargets:
chromosome [GO:0005694]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA topoisomerase type I activity [GO:0003917]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969P6-1; Sequence=Displayed; Name=2; IsoId=Q969P6-2; Sequence=VSP_044783; Note=No experimental confirmation available.; 


uniprotID: Q02223
geneSymbol: TNFRSF17
reactome: R-HSA-5669034;
pdb: 1OQD;1XU2;2KN1;4ZFO;
name: Tumor necrosis factor receptor superfamily member 17 (B-cell maturation protein) (CD antigen CD269)
length: 184
go: ENSG00000048462;
snps: rs11570146 rs11570147 rs11570148 rs373496 rs150352299 rs11570159 rs34546237
sequence:
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCLGLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLEYTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKSISAR

opentargets:
endomembrane system [GO:0012505]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; cell proliferation [GO:0008283]; lymphocyte homeostasis [GO:0002260]; multicellular organism development [GO:0007275]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q02223-1; Sequence=Displayed; Name=2; Synonyms=TV4; IsoId=Q02223-2; Sequence=VSP_047678; Note=Observed only in some CD19+ cell.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.


uniprotID: Q6PF06
geneSymbol: TRMT10B
length: 316
go: ENSG00000165275;
snps: rs36023446 rs12337034
name:
tRNA methyltransferase 10 homolog B (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 3) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10B)

sequence:

opentargets:
cytosol [GO:0005829]; tRNA (guanine(9)-N(1))-methyltransferase activity [GO:0052905]; tRNA (guanine-N1-)-methyltransferase activity [GO:0009019]; tRNA binding [GO:0000049]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q6PF06-1; Sequence=Displayed; Name=2; IsoId=Q6PF06-2; Sequence=VSP_029519; Note=No experimental confirmation available.; Name=5; IsoId=Q6PF06-5; Sequence=VSP_055735, VSP_054653; Name=3; IsoId=Q6PF06-3; Sequence=VSP_029520, VSP_029521; Note=No experimental confirmation available.; Name=4; IsoId=Q6PF06-4; Sequence=VSP_054652, VSP_054653; Note=No experimental confirmation available.; 


uniprotID: Q7Z2V1
geneSymbol: C16orf82
name: Protein TNT
length: 217
sequence:


uniprotID: Q9P2C4
geneSymbol: TMEM181
name: Transmembrane protein 181
length: 612
go: ENSG00000146433;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; toxic substance binding [GO:0015643]; pathogenesis [GO:0009405]


uniprotID: A0A286YF58
geneSymbol: TMEM271
name: Transmembrane protein 271
length: 385
go: ENSG00000273238;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: O43711
geneSymbol: TLX3
name: T-cell leukemia homeobox protein 3 (Homeobox protein Hox-11L2)
length: 291
go: ENSG00000164438;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; central nervous system development [GO:0007417]; negative regulation of neuron differentiation [GO:0045665]; neuron fate specification [GO:0048665]; neuron migration [GO:0001764]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; respiratory gaseous exchange [GO:0007585]


uniprotID: Q5T215
geneSymbol: TRAPPC3L
length: 181
go: ENSG00000173626;
name:
Trafficking protein particle complex subunit 3-like protein (TRAPPC3-like protein) (BET3-like protein)

sequence:
MSRPAHRRPEYHKINKDLFVLTYGALVAQLCKDYEKDEDVNQYLDKMGYGIGTRLVEDFLARSCVGRCHSYSEIIDIIAQVAFKMYLGITPSVTCNNSSKNEFSLILEKNPLVEFVEELPAGRSSLCYCNLLCGIIRGALEMVHLAADVTFLQDRLKGDSVTEIGITFLKKRDEKKYRGKK

opentargets:
cis-Golgi network membrane [GO:0033106]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; TRAPP complex [GO:0030008]; ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T215-1; Sequence=Displayed; Name=2; IsoId=Q5T215-2; Sequence=VSP_028222; 


uniprotID: Q9Y3Q3
geneSymbol: TMED3
reactome: R-HSA-6807878;R-HSA-6811434;
length: 217
go: ENSG00000166557;
snps: rs3784543
name:
Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26)

sequence:

opentargets:
COPI vesicle coat [GO:0030126]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; transport vesicle [GO:0030133]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3Q3-1; Sequence=Displayed; Name=2; IsoId=Q9Y3Q3-2; Sequence=VSP_044371; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q6AY25}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000305|PubMed:16940185}; Single-pass type I membrane protein {ECO:0000255}. Note=Probably cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:10852829}.


uniprotID: Q15388
geneSymbol: TOMM20
reactome: R-HSA-1268020;R-HSA-5205685;R-HSA-5689880;
pdb: 4APO;
length: 145
go: ENSG00000173726;
snps: rs16991984 rs1049510
name:
Mitochondrial import receptor subunit TOM20 homolog (Mitochondrial 20 kDa outer membrane protein) (Outer mitochondrial membrane receptor Tom20)

sequence:
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE

opentargets:
integral component of mitochondrial outer membrane [GO:0031307]; Mitochondria-associated ER Membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; mitochondrion targeting sequence binding [GO:0030943]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; unfolded protein binding [GO:0051082]; mitochondrial outer membrane translocase complex assembly [GO:0070096]; protein deubiquitination [GO:0016579]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]; response to 3,3',5-triiodo-L-thyronine [GO:1905242]; response to muscle activity [GO:0014850]; tRNA import into mitochondrion [GO:0016031]

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101}; Single-pass membrane protein {ECO:0000255}.


uniprotID: Q8N9M5
geneSymbol: TMEM102
name: Transmembrane protein 102 (Common beta-chain associated protein) (CBAP)
length: 508
go: ENSG00000181284;
snps: rs3809718
sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; apoptotic process [GO:0006915]; positive regulation of cell adhesion [GO:0045785]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell migration [GO:2000406]; regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [GO:1901028]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]; response to cytokine [GO:0034097]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17828305}; Single-pass membrane protein {ECO:0000269|PubMed:17828305}. Note=Although it is found at the cell surface, the majority of the molecules seems to be located in intracellular compartments.


uniprotID: A6NLX4
geneSymbol: TMEM210
name: Transmembrane protein 210
length: 147
go: ENSG00000185863;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MAPGPWPVSCLRGGPLGLTYLSLLLIPAAAGTYCECSLGLSREALIALLVVLAGISASCFCALVIVAIGVLRAKGETCPRQVDNRLVENFGVQEDLMDLHPVYVESQLMDADLEVSLVPPLEDQSLVAIPMEASSEEPPPPPPLPPE


uniprotID: Q8NEW7
geneSymbol: TMIE
name: Transmembrane inner ear expressed protein
length: 156
go: ENSG00000181585;
snps: rs28942096 rs28942097 rs28941781
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MAGWPGAGPLCVLGGAALGVCLAGVAGQLVEPSTAPPKPKPPPLTKETVVFWDMRLWHVVGIFSLFVLSIIITLCCVFNCRVPRTRKEIEARYLQRKAAKMYTDKLETVPPLNELTEVPGEDKKKKKKKKKDSVDTVAIKVEEDEKNEAKKKKGEK

opentargets:
integral component of membrane [GO:0016021]; inner ear morphogenesis [GO:0042472]; sensory perception of sound [GO:0007605]


uniprotID: Q6NUQ4
geneSymbol: TMEM214
name: Transmembrane protein 214
length: 689
go: ENSG00000119777;
snps: rs1124649
sequence:

opentargets:
cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; apoptotic process [GO:0006915]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NUQ4-1; Sequence=Displayed; Name=2; IsoId=Q6NUQ4-2; Sequence=VSP_041155; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23661706}; Multi-pass membrane protein {ECO:0000269|PubMed:23661706}.


uniprotID: Q6UE05
geneSymbol: TMEM270
name: Transmembrane protein 270 (Williams-Beuren syndrome chromosomal region 28 protein)
length: 265
go: ENSG00000175877;
opentargets: integral component of membrane [GO:0016021]
snps: rs11770052 rs56933025 rs17852792 rs13227841
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6UE05-1; Sequence=Displayed; Name=2; IsoId=Q6UE05-2; Sequence=VSP_039997, VSP_039998; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q6UW68
geneSymbol: TMEM205
name: Transmembrane protein 205
length: 189
go: ENSG00000105518;
opentargets: integral component of membrane [GO:0016021]
sequence:
MEEGGNLGGLIKMVHLLVLSGAWGMQMWVTFVSGFLLFRSLPRHTFGLVQSKLFPFYFHISMGCAFINLCILASQHAWAQLTFWEASQLYLLFLSLTLATVNARWLEPRTTAAMWALQTVEKERGLGGEVPGSHQGPDPYRQLREKDPKYSALRQNFFRYHGLSSLCNLGCVLSNGLCLAGLALEIRSL

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20589834}; Multi-pass membrane protein {ECO:0000269|PubMed:20589834}. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.


uniprotID: P43489
geneSymbol: TNFRSF4
reactome: R-HSA-5669034;
pdb: 1D0A;2HEV;2HEY;
length: 277
go: ENSG00000186827;
snps: rs35304565 rs587777075
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134)

sequence:

opentargets:
cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; tumor necrosis factor-activated receptor activity [GO:0005031]; virus receptor activity [GO:0001618]; cellular defense response [GO:0006968]; immune response [GO:0006955]; inflammatory response [GO:0006954]; negative regulation of activation-induced cell death of T cells [GO:0070236]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of immunoglobulin secretion [GO:0051024]; regulation of protein kinase activity [GO:0045859]; T cell proliferation [GO:0042098]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: O94842
geneSymbol: TOX4
name: TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1)
length: 621
go: ENSG00000092203;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:20516061}. Note=Associated with chromatin.
sequence:

opentargets:
chromatin [GO:0000785]; nucleus [GO:0005634]; PTW/PP1 phosphatase complex [GO:0072357]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O94842-1; Sequence=Displayed; Name=2; IsoId=O94842-2; Sequence=VSP_053873; Note=No experimental confirmation available.; Name=3; IsoId=O94842-3; Sequence=VSP_055512; Note=No experimental confirmation available.; 


uniprotID: Q8WZ42
geneSymbol: TTN
reactome: R-HSA-114608;R-HSA-390522;
name: Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
length: 34350
go: ENSG00000155657;
pdb:
1BPV;1G1C;1NCT;1NCU;1TIT;1TIU;1TKI;1TNM;1TNN;1WAA;1YA5;2A38;2BK8;2F8V;2ILL;2J8H;2J8O;2NZI;2RQ8;2WP3;2WWK;2WWM;2Y9R;3B43;3KNB;3LCY;3LPW;3PUC;3Q5O;3QP3;4C4K;4JNW;4O00;4QEG;4UOW;5BS0;5JDD;5JDE;5JDJ;5JOE;

sequence:

opentargets:
condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; I band [GO:0031674]; M band [GO:0031430]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; actinin binding [GO:0042805]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; muscle alpha-actinin binding [GO:0051371]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; protein self-association [GO:0043621]; protein serine/threonine kinase activity [GO:0004674]; protein tyrosine kinase activity [GO:0004713]; structural constituent of muscle [GO:0008307]; structural molecule activity conferring elasticity [GO:0097493]; telethonin binding [GO:0031433]; cardiac muscle contraction [GO:0060048]; cardiac muscle fiber development [GO:0048739]; cardiac muscle hypertrophy [GO:0003300]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac myofibril assembly [GO:0055003]; detection of muscle stretch [GO:0035995]; mitotic chromosome condensation [GO:0007076]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; platelet degranulation [GO:0002576]; positive regulation of gene expression [GO:0010628]; positive regulation of protein secretion [GO:0050714]; protein kinase A signaling [GO:0010737]; regulation of catalytic activity [GO:0050790]; regulation of protein kinase activity [GO:0045859]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; sarcomerogenesis [GO:0048769]; skeletal muscle myosin thick filament assembly [GO:0030241]; skeletal muscle thin filament assembly [GO:0030240]; striated muscle contraction [GO:0006941]

snps:
rs139517732 rs35683768 rs564777385 rs138060032 rs16866538 rs56128843 rs72647851 rs28933405 rs267607157 rs149061352 rs35813871 rs56046320 rs267607155 rs55914517 rs72647870 rs10497520 rs150667217 rs1552280 rs1552280 rs36021856 rs267599092 rs539470256 rs36062108 rs16866531 rs72647875 rs72647876 rs72647877 rs12476289 rs56270960 rs375029799 rs370004591 rs75686037 rs150725992 rs144135510 rs56404770 rs56285559 rs4894048 rs571572592 rs56142888 rs576644663 rs33917087 rs2306636 rs56373393 rs200875815 rs11900987 rs4893853 rs33997263 rs397517792 rs55634230 rs2291311 rs34819099 rs2291310 rs2627037 rs55853696 rs2627037 rs34070843 rs34618570 rs56244420 rs200431386 rs2562829 rs56030296 rs1883085 rs55857742 rs55906845 rs281864908 rs16866412 rs4893852 rs55723264 rs2288563 rs34706299 rs199684560 rs778634417 rs6723526 rs200914097 rs1458591077 rs373298007 rs571522834 rs74580375 rs144668626 rs114331773 rs184078045 rs17354992 rs72677225 rs72677232 rs72677233 rs146181477 rs200944827 rs55663050 rs36043230 rs16866412 rs751398376 rs201825412 rs200650668 rs370390570 rs755155531 rs554368924 rs780672348 rs72646808 rs2303832 rs72646809 rs373526624 rs55734111 rs3813243 rs55809450 rs72646823 rs1001238 rs56025724 rs2288569 rs374713701 rs769852851 rs200732032 rs16866406 rs141973925 rs1470758075 rs199895260 rs1383995916 rs72646850 rs773075736 rs202240487 rs2042996 rs181717727 rs150661999 rs141965360 rs72646861 rs13021201 rs56378177 rs55948748 rs200217934 rs9808036 rs72646869 rs2303838 rs72646873 rs534340303 rs55980498 rs56141309 rs55853138 rs55713867 rs55801134 rs56071233 rs55903402 rs55677134 rs55885640 rs55837610 rs56019808 rs10164753 rs56399205 rs55992239 rs56201325 rs55991022 rs764005465 rs369098292 rs55762754 rs55713856 rs744426 rs3813243 rs55984930 rs3813245 rs56372592 rs56391938 rs4894028 rs3813246 rs56340968 rs56018860 rs56341835 rs12463674 rs3731745 rs56044609 rs56307213 rs3731746 rs55850344 rs56365600 rs56137800 rs55933739 rs375422359 rs56264840 rs55634791 rs56309296 rs3829746 rs56057221 rs56330345 rs1186947794 rs191482653 rs55898359 rs55940667 rs9808377 rs139506970 rs77853750 rs72648238 rs149567378 rs114026724 rs148617456 rs535151633 rs376628842 rs373049260 rs747122 rs16866391 rs750303653 rs1310673663 rs72648256 rs72648257 rs142525903 rs191484894 rs62621206 rs62621236 rs56027402 rs397517769 rs56009327 rs55915651 rs55660660 rs56066673 rs56233675 rs3731749 rs55676195 rs55704830 rs72648270 rs72648272 rs72648273 rs149001703 rs55653324 rs4894028 rs56061641 rs55742743 rs55675869 rs55880786 rs2278196 rs56273463 rs34924609 rs55886356 rs55669553 rs756924372 rs56347248 rs56173891 rs3731752 rs148525155 rs55945684 rs3829747 rs199642423 rs55866005 rs1003158162 rs56001826 rs56308529 rs55865284 rs56365812 rs56324595 rs16866380 rs55725279 rs55880440 rs55842557 rs16866378 rs281864928 rs267607156 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=13;  Comment=A number of isoforms may be produced, ranging from 27000 to 33000 residues in different striated muscle tissues, the size of the full-length protein may be up to 38138 residues.; Name=1; IsoId=Q8WZ42-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8WZ42-2; Sequence=VSP_019138; Note=No experimental confirmation available.; Name=3; Synonyms=Small cardiac N2-B; IsoId=Q8WZ42-3; Sequence=VSP_019139, VSP_019145; Name=4; Synonyms=Soleus; IsoId=Q8WZ42-4; Sequence=VSP_019142, VSP_019151; Note=No experimental confirmation available.; Name=5; IsoId=Q8WZ42-5; Sequence=VSP_019147, VSP_019148, VSP_019149, VSP_019150, VSP_019152; Note=No experimental confirmation available.; Name=6; Synonyms=Small cardiac novex-3; IsoId=Q8WZ42-6; Sequence=VSP_019143, VSP_019146; Name=7; Synonyms=Cardiac novex-2; IsoId=Q8WZ42-7; Sequence=VSP_019141, VSP_019144; Name=8; Synonyms=Cardiac novex-1; IsoId=Q8WZ42-8; Sequence=VSP_019140; Name=9; IsoId=Q8WZ42-9; Sequence=VSP_019139, VSP_042903, VSP_019145; Name=10; IsoId=Q8WZ42-10; Sequence=VSP_019139, VSP_019140, VSP_019145; Name=11; IsoId=Q8WZ42-11; Sequence=VSP_019142; Name=12; IsoId=Q8WZ42-12; Sequence=VSP_045935, VSP_045929, VSP_045930, VSP_045931, VSP_045932, VSP_045933, VSP_045934; Note=No experimental confirmation available.; Name=13; IsoId=Q8WZ42-13; Sequence=VSP_047142; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:16410549}. Nucleus {ECO:0000269|PubMed:16410549}.


uniprotID: Q5JTD0
geneSymbol: TJAP1
length: 557
go: ENSG00000137221;
name:
Tight junction-associated protein 1 (Protein incorporated later into tight junctions) (Tight junction protein 4)

sequence:

opentargets:
bicellular tight junction [GO:0005923]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; Golgi organization [GO:0007030]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5JTD0-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q5JTD0-2; Sequence=VSP_016002; Name=3; IsoId=Q5JTD0-3; Sequence=VSP_016000; Note=No experimental confirmation available.; Name=4; IsoId=Q5JTD0-4; Sequence=VSP_015999, VSP_016001, VSP_016002; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Recruited to tight junctions (TJ) during late stages of maturation of the TJ complexes. Excluded from adherens junctions and desmosomes (By similarity). {ECO:0000250}.


uniprotID: O43897
geneSymbol: TLL1
reactome: R-HSA-1474228;R-HSA-1650814;R-HSA-2214320;R-HSA-2243919;
pdb: 3EDI;
name: Tolloid-like protein 1 (EC 3.4.24.-)
length: 1013
go: ENSG00000038295;
snps: rs137852951 rs137852952 rs137852953 rs2291822
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; extracellular matrix disassembly [GO:0022617]; skeletal system development [GO:0001501]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43897-1; Sequence=Displayed; Name=2; IsoId=O43897-2; Sequence=VSP_017197, VSP_017198; Note=No experimental confirmation available.; 


uniprotID: Q8WVP5
geneSymbol: TNFAIP8L1
reactome: R-HSA-1483255;
length: 186
go: ENSG00000185361;
snps: rs17851549
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K288}.
name:
Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta)

sequence:
MDTFSTKSLALQAQKKLLSKMASKAVVAVLVDDTSSEVLDELYRATREFTRSRKEAQKMLKNLVKVALKLGLLLRGDQLGGEELALLRRFRHRARCLAMTAVSFHQVDFTFDRRVLAAGLLECRDLLHQAVGPHLTAKSHGRINHVFGHLADCDFLAALYGPAEPYRSHLRRICEGLGRMLDEGSL

opentargets:
cytoplasm [GO:0005737]; negative regulation of TOR signaling [GO:0032007]; regulation of apoptotic process [GO:0042981]


uniprotID: Q9BVK6
geneSymbol: TMED9
reactome: R-HSA-6807878;R-HSA-6811434;
length: 235
go: ENSG00000184840;
snps: rs57960711
name:
Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25)

sequence:

opentargets:
COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; trans-Golgi network transport vesicle [GO:0030140]; transport vesicle [GO:0030133]; syntaxin binding [GO:0019905]; COPI coating of Golgi vesicle [GO:0048205]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; positive regulation of organelle organization [GO:0010638]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.


