# annotation

uniprotID: P11217
geneSymbol: PYGM
reactome: R-HSA-70221;
pdb: 1Z8D;
name: Glycogen phosphorylase, muscle form (EC 2.4.1.1) (Myophosphorylase)
length: 842
go: ENSG00000068976;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen phosphorylase activity [GO:0008184]; linear malto-oligosaccharide phosphorylase activity [GO:0102250]; nucleotide binding [GO:0000166]; pyridoxal phosphate binding [GO:0030170]; SHG alpha-glucan phosphorylase activity [GO:0102499]; glycogen catabolic process [GO:0005980]; glycogen metabolic process [GO:0005977]

drug:
DB04544;DB04013;DB03657;DB02320;DB02604;DB04044;DB03383;DB02720;DB02007;DB02843;DB01823;DB02379;DB03286;DB02719;DB03496;DB02348;DB04195;DB02519;DB04566;DB04083;DB03218;DB04295;DB02471;DB04522;DB00114;

snps:
rs776680924 rs376581557 rs119103251 rs780375860 rs1005687078 rs11231866 rs119103252 rs750195683 rs119103253 rs119103256 rs144081869 rs119103258 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P11217-1; Sequence=Displayed; Name=2; IsoId=P11217-2; Sequence=VSP_043047; Note=No experimental confirmation available.; 


uniprotID: Q9NR77
geneSymbol: PXMP2
reactome: R-HSA-389661;
name: Peroxisomal membrane protein 2 (22 kDa peroxisomal membrane protein)
length: 195
go: ENSG00000176894;
location: SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
sequence:
MAPAASRLRAEAGLGALPRRALAQYLLFLRLYPVLTKAATSGILSALGNFLAQMIEKKRKKENSRSLDVGGPLRYAVYGFFFTGPLSHFFYFFMEHWIPPEVPLAGLRRLLLDRLVFAPAFLMLFFLIMNFLEGKDASAFAAKMRGGFWPALRMNWRVWTPLQFININYVPLKFRVLFANLAALFWYAYLASLGK

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; peroxisomal membrane [GO:0005778]; protein-containing complex [GO:0032991]


uniprotID: Q9Y3T6
geneSymbol: R3HCC1
name: R3H and coiled-coil domain-containing protein 1
length: 440
opentargets: nucleic acid binding [GO:0003676]
snps: rs6980542 rs3808536 rs2272761 rs13530
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3T6-1; Sequence=Displayed; Name=2; IsoId=Q9Y3T6-3; Sequence=VSP_058566; 


uniprotID: P50876
geneSymbol: RNF144A
reactome: R-HSA-8866654;
pdb: 1WIM;
length: 292
go: ENSG00000151692;
snps: rs364891
name:
E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24979766}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24979766}.


uniprotID: P01116
geneSymbol: KRAS
length: 189
go: ENSG00000133703;
drug: DB07780;
reactome:
R-HSA-112412;R-HSA-1169092;R-HSA-1236382;R-HSA-1250196;R-HSA-1250347;R-HSA-1433557;R-HSA-167044;R-HSA-171007;R-HSA-179812;R-HSA-180336;R-HSA-186763;R-HSA-1963640;R-HSA-210993;R-HSA-2179392;R-HSA-2424491;R-HSA-2428933;R-HSA-2871796;R-HSA-375165;R-HSA-5218921;R-HSA-5621575;R-HSA-5637810;R-HSA-5654688;R-HSA-5654693;R-HSA-5654699;R-HSA-5654700;R-HSA-5654704;R-HSA-5654706;R-HSA-5654712;R-HSA-5654719;R-HSA-5655253;R-HSA-5655291;R-HSA-5655302;R-HSA-5658442;R-HSA-5673000;R-HSA-5673001;R-HSA-5674135;R-HSA-5675221;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802953;R-HSA-6802955;R-HSA-74751;R-HSA-8849471;R-HSA-8851805;R-HSA-8853334;R-HSA-8853338;R-HSA-8951936;R-HSA-9026519;R-HSA-9028731;R-HSA-9034864;

pdb:
1D8D;1D8E;1KZO;1KZP;1N4P;1N4Q;1N4R;1N4S;3GFT;4DSN;4DSO;4EPR;4EPT;4EPV;4EPW;4EPX;4EPY;4L8G;4LDJ;4LPK;4LRW;4LUC;4LV6;4LYF;4LYH;4LYJ;4M1O;4M1S;4M1T;4M1W;4M1Y;4M21;4M22;4NMM;4OBE;4PZY;4PZZ;4Q01;4Q02;4Q03;4QL3;4TQ9;4TQA;4WA7;5F2E;5KYK;5MLA;5MLB;5O2S;5O2T;5OCG;5OCO;5OCT;5TAR;5TB5;5UFE;5UFQ;5UK9;5UQW;5US4;5USJ;5V6S;5V6V;5V71;5V9L;5V9O;5V9U;5VBM;5VP7;5VPI;5VPY;5VPZ;5VQ0;5VQ1;5VQ2;5VQ6;5VQ8;5W22;5WHA;5WHB;5WHD;5WHE;5WLB;5WPM;5XCO;5YXZ;5YY1;6ARK;6ASA;6ASE;6B0V;6B0Y;6BP1;6CC9;6CCH;6CCX;6F76;6FA1;6FA2;6FA3;6FA4;

name:
GTPase KRas (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]

sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GMP binding [GO:0019002]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; LRR domain binding [GO:0030275]; protein-containing complex binding [GO:0044877]; actin cytoskeleton organization [GO:0030036]; cytokine-mediated signaling pathway [GO:0019221]; endocrine signaling [GO:0038002]; epithelial tube branching involved in lung morphogenesis [GO:0060441]; female pregnancy [GO:0007565]; forebrain astrocyte development [GO:0021897]; homeostasis of number of cells within a tissue [GO:0048873]; liver development [GO:0001889]; MAPK cascade [GO:0000165]; negative regulation of cell differentiation [GO:0045596]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cellular senescence [GO:2000774]; positive regulation of gene expression [GO:0010628]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric-oxide synthase activity [GO:0051000]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rac protein signal transduction [GO:0035022]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein stability [GO:0031647]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to glucocorticoid [GO:0051384]; response to isolation stress [GO:0035900]; response to mineralocorticoid [GO:0051385]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; striated muscle cell differentiation [GO:0051146]; visual learning [GO:0008542]

snps:
rs193929331 rs104894361 rs121913529 rs121913530 rs121913529 rs121913530 rs121913530 rs121913529 rs112445441 rs121913535 rs104894365 rs727503110 rs104894366 rs104894366 rs727503109 rs104894364 rs121913528 rs104894359 rs104894359 rs17851045 rs121913240 rs387907205 rs770248150 rs121913527 rs387907206 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Isoforms differ in the C-terminal region which is encoded by two alternative exons (IVA and IVB).; Name=2A; Synonyms=K-Ras4A; IsoId=P01116-1; Sequence=Displayed; Name=2B; Synonyms=K-Ras4B; IsoId=P01116-2, P01118-1; Sequence=VSP_011140, VSP_011141; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:23698361}; Lipid-anchor {ECO:0000305|PubMed:23698361}; Cytoplasmic side {ECO:0000305|PubMed:23698361}. Cytoplasm, cytosol {ECO:0000269|PubMed:23698361}.


uniprotID: Q9Y2K5
geneSymbol: R3HDM2
pdb: 1WHR;
name: R3H domain-containing protein 2
length: 976
go: ENSG00000179912;
opentargets: nucleus [GO:0005634]; RNA binding [GO:0003723]
snps: rs11832661
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y2K5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2K5-2; Sequence=VSP_026087, VSP_026088; Name=3; IsoId=Q9Y2K5-3; Sequence=VSP_057391, VSP_057392; Note=No experimental confirmation available.; 


uniprotID: A8MTL3
geneSymbol: RNF212B
name: RING finger protein 212B
length: 300
go: ENSG00000215277;
sequence:

opentargets:
synaptonemal complex [GO:0000795]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; protein sumoylation [GO:0016925]; synapsis [GO:0007129]


uniprotID: P61106
geneSymbol: RAB14
reactome: R-HSA-1445148;R-HSA-1660499;R-HSA-6798695;R-HSA-8873719;R-HSA-8876198;
pdb: 1Z0F;4D0G;4DRZ;
name: Ras-related protein Rab-14
length: 215
go: ENSG00000119396;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular [GO:0005622]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; nuclear outer membrane-endoplasmic reticulum membrane network [GO:0042175]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; rough endoplasmic reticulum [GO:0005791]; tertiary granule membrane [GO:0070821]; trans-Golgi network [GO:0005802]; trans-Golgi network transport vesicle [GO:0030140]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; defense response to bacterium [GO:0042742]; endocytic recycling [GO:0032456]; fibroblast growth factor receptor signaling pathway [GO:0008543]; Golgi to endosome transport [GO:0006895]; intracellular protein transport [GO:0006886]; intracellular transport [GO:0046907]; neutrophil degranulation [GO:0043312]; phagolysosome assembly involved in apoptotic cell clearance [GO:0090387]; phosphatidylinositol biosynthetic process [GO:0006661]; Rab protein signal transduction [GO:0032482]; regulation of embryonic development [GO:0045995]; regulation of protein localization [GO:0032880]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:22595670}. Early endosome membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16962593}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:22595670}.


uniprotID: P59190
geneSymbol: RAB15
reactome: R-HSA-8873719;
name: Ras-related protein Rab-15
length: 212
go: ENSG00000139998;
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; positive regulation of regulated secretory pathway [GO:1903307]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P59190-1; Sequence=Displayed; Name=2; IsoId=P59190-2; Sequence=VSP_010420; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.


uniprotID: Q9UL25
geneSymbol: RAB21
reactome: R-HSA-8873719;R-HSA-8876198;
pdb: 1YZT;1YZU;1Z08;1Z0I;2OT3;
name: Ras-related protein Rab-21
length: 225
go: ENSG00000080371;
sequence:

opentargets:
axon cytoplasm [GO:1904115]; cleavage furrow [GO:0032154]; cytoplasmic side of early endosome membrane [GO:0098559]; cytoplasmic side of plasma membrane [GO:0009898]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi cisterna membrane [GO:0032580]; synapse [GO:0045202]; trans-Golgi network [GO:0005802]; vesicle membrane [GO:0012506]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; anterograde axonal transport [GO:0008089]; intracellular protein transport [GO:0006886]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of receptor-mediated endocytosis [GO:0048260]; Rab protein signal transduction [GO:0032482]; regulation of axon extension [GO:0030516]; regulation of exocytosis [GO:0017157]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10887961}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16525121}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10887961}. Cleavage furrow {ECO:0000269|PubMed:18804435}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}.


uniprotID: P29762
geneSymbol: CRABP1
reactome: R-HSA-5365859;
name: Cellular retinoic acid-binding protein 1 (Cellular retinoic acid-binding protein I) (CRABP-I)
length: 137
go: ENSG00000166426;
drug: DB00523;DB00926;DB00755;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11909957}.
sequence:
MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQFYIKTSTTVRTTEINFKVGEGFEEETVDGRKCRSLATWENENKIHCTQTLLEGDGPKTYWTRELANDELILTFGADDVVCTRIYVRE

opentargets:
cytosol [GO:0005829]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; multicellular organism development [GO:0007275]; retinoic acid catabolic process [GO:0034653]; signal transduction [GO:0007165]


uniprotID: Q9UPQ7
geneSymbol: PDZRN3
pdb: 1UHP;1WH1;
length: 1066
go: ENSG00000121440;
snps: rs3205537
name:
E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)

sequence:

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; neuromuscular junction development [GO:0007528]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UPQ7-1; Sequence=Displayed; Name=2; IsoId=Q9UPQ7-2; Sequence=VSP_012606, VSP_012607; Note=No experimental confirmation available.; Name=3; IsoId=Q9UPQ7-3; Sequence=VSP_012608, VSP_012609; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250|UniProtKB:Q69ZS0}. Cytoplasm {ECO:0000250|UniProtKB:E7FDW2}. Note=Localizes to the postsynaptic region of neuromuscular junctions. {ECO:0000250|UniProtKB:Q69ZS0}.


uniprotID: P29373
geneSymbol: CRABP2
reactome: R-HSA-5362517;
name: Cellular retinoic acid-binding protein 2 (Cellular retinoic acid-binding protein II) (CRABP-II)
length: 138
go: ENSG00000143320;
drug: DB00523;DB00755;
pdb:
1BLR;1BM5;1CBQ;1CBS;1XCA;2CBS;2FR3;2FRS;2FS6;2FS7;2G78;2G79;2G7B;3CBS;3CR6;3CWK;3D95;3D96;3D97;3F8A;3F9D;3FA6;3FA7;3FA8;3FA9;3FEK;3FEL;3FEN;3FEP;3I17;4I9R;4I9S;4M6S;4M7M;4QGV;4QGW;4QGX;4YBP;4YBU;4YCE;4YCH;4YDA;4YDB;4YFP;4YFQ;4YFR;4YGG;4YGH;4YGZ;4YH0;4YKM;4YKO;5HZQ;

sequence:
MPNFSGNWKIIRSENFEELLKVLGVNVMLRKIAVAAASKPAVEIKQEGDTFYIKTSTTVRTTEINFKVGEEFEEQTVDGRPCKSLVKWESENKMVCEQKLLKGEGPKTSWTRELTNDGELILTMTADDVVCTRVYVRE

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; retinal binding [GO:0016918]; retinoic acid binding [GO:0001972]; retinoid binding [GO:0005501]; retinol binding [GO:0019841]; embryonic forelimb morphogenesis [GO:0035115]; epidermis development [GO:0008544]; positive regulation of collateral sprouting [GO:0048672]; regulation of retinoic acid receptor signaling pathway [GO:0048385]; regulation of transcription, DNA-templated [GO:0006355]; retinoic acid biosynthetic process [GO:0002138]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum. Nucleus. Note=Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.


uniprotID: P15153
geneSymbol: RAC2
reactome: R-HSA-114604;R-HSA-194840;R-HSA-4086400;R-HSA-416482;R-HSA-5668599;
pdb: 1DS6;2W2T;2W2V;2W2X;
name: Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
length: 192
go: ENSG00000128340;
drug: DB00514;
snps: rs74315507
location: SUBCELLULAR LOCATION: Cytoplasm. Note=Membrane-associated when activated.
sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRACSLL

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear envelope [GO:0005635]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase regulator activity [GO:0019887]; actin filament organization [GO:0007015]; bone resorption [GO:0045453]; cell projection assembly [GO:0030031]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; lymphocyte aggregation [GO:0071593]; neuron projection morphogenesis [GO:0048812]; positive regulation of cell proliferation [GO:0008284]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein targeting to mitochondrion [GO:1903955]; Rac protein signal transduction [GO:0016601]; regulation of cell-substrate adhesion [GO:0010810]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of mast cell chemotaxis [GO:0060753]; regulation of mast cell degranulation [GO:0043304]; regulation of neutrophil migration [GO:1902622]; regulation of respiratory burst [GO:0060263]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of T cell proliferation [GO:0042129]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]


uniprotID: O15315
geneSymbol: RAD51B
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693616;R-HSA-983231;
name: DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)
length: 384
go: ENSG00000182185;
snps: rs34583846 rs35282642 rs34094401 rs28910275 rs28908168 rs34594234 rs33929366 rs28908468
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent ATPase activity [GO:0008094]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; blood coagulation [GO:0007596]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=O15315-3; Sequence=Displayed; Name=2; Synonyms=RAD51L1a; IsoId=O15315-1; Sequence=VSP_008819; Name=3; Synonyms=RAD51L1b; IsoId=O15315-2; Sequence=VSP_008818; Name=4; IsoId=O15315-4; Sequence=VSP_008820; Note=No experimental confirmation available.; Name=5; IsoId=O15315-5; Sequence=VSP_008817, VSP_008818; Note=No experimental confirmation available.; 


uniprotID: Q96PU8
geneSymbol: QKI
reactome: R-HSA-6802952;
pdb: 4JVH;
name: Protein quaking (Hqk) (HqkI)
length: 341
go: ENSG00000112531;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]; SH3 domain binding [GO:0017124]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; multicellular organism development [GO:0007275]; regulation of translation [GO:0006417]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=HQK-5, QKI-5; IsoId=Q96PU8-1; Sequence=Displayed; Name=2; IsoId=Q96PU8-3; Sequence=VSP_019188; Name=3; IsoId=Q96PU8-5; Sequence=VSP_019188, VSP_019190; Name=4; Synonyms=HQK-7; IsoId=Q96PU8-6; Sequence=VSP_019190; Name=5; Synonyms=HQK-7B; IsoId=Q96PU8-8; Sequence=VSP_019191; Name=6; IsoId=Q96PU8-9; Sequence=VSP_019189; Note=No experimental confirmation available.; 


uniprotID: P51151
geneSymbol: RAB9A
reactome: R-HSA-6811440;R-HSA-8873719;R-HSA-8876198;
pdb: 1WMS;
name: Ras-related protein Rab-9A
length: 201
go: ENSG00000123595;
drug: DB03793;DB04315;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; intracellular protein transport [GO:0006886]; negative regulation by host of symbiont molecular function [GO:0052405]; positive regulation of exocytosis [GO:0045921]; Rab protein signal transduction [GO:0032482]; regulation of protein localization [GO:0032880]; retrograde transport, endosome to Golgi [GO:0042147]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}. Late endosome {ECO:0000269|PubMed:16176980}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9R0M6}. Melanosome {ECO:0000250|UniProtKB:Q9R0M6}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211}.


uniprotID: Q9H6Z4
geneSymbol: RANBP3
pdb: 2CRF;2Y8F;2Y8G;5XZX;
name: Ran-binding protein 3 (RanBP3)
length: 567
go: ENSG00000031823;
snps: rs10417885
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; R-SMAD binding [GO:0070412]; Ran GTPase binding [GO:0008536]; positive regulation of GTPase activity [GO:0043547]; protein export from nucleus [GO:0006611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H6Z4-1; Sequence=Displayed; Name=2; Synonyms=Ranbp3-a; IsoId=Q9H6Z4-2; Sequence=VSP_011162; Name=3; Synonyms=Ranbp3-b; IsoId=Q9H6Z4-3; Sequence=VSP_011163; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19289081}. Nucleus {ECO:0000269|PubMed:19289081}.


uniprotID: Q2KHR3
geneSymbol: QSER1
name: Glutamine and serine-rich protein 1
length: 1735
go: ENSG00000060749;
snps: rs1022586 rs2297781 rs7940077 rs16923676
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2KHR3-1; Sequence=Displayed; Name=2; IsoId=Q2KHR3-2; Sequence=VSP_039815, VSP_039816; Note=No experimental confirmation available.; 


uniprotID: Q7Z419
geneSymbol: RNF144B
reactome: R-HSA-983168;
length: 303
go: ENSG00000137393;
name:
E3 ubiquitin-protein ligase RNF144B (EC 2.3.2.31) (IBR domain-containing protein 2) (RING finger protein 144B) (p53-inducible RING finger protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; mitochondrial membrane [GO:0031966]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z419-1; Sequence=Displayed; Name=2; IsoId=Q7Z419-2; Sequence=VSP_055853, VSP_055854; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:20300062}; Single-pass membrane protein {ECO:0000269|PubMed:20300062}. Cytoplasm {ECO:0000269|PubMed:20300062}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.


uniprotID: Q9H0T7
geneSymbol: RAB17
reactome: R-HSA-8873719;
name: Ras-related protein Rab-17
length: 212
go: ENSG00000124839;
snps: rs3751112 rs34311889 rs2280289
sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; dendrite [GO:0030425]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; melanosome [GO:0042470]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cilium assembly [GO:0060271]; endocytic recycling [GO:0032456]; establishment of melanosome localization [GO:0032401]; filopodium assembly [GO:0046847]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; Rab protein signal transduction [GO:0032482]; regulation of dendrite development [GO:0050773]; regulation of endocytosis [GO:0030100]; regulation of filopodium assembly [GO:0051489]; regulation of synapse assembly [GO:0051963]; transcytosis [GO:0045056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H0T7-1; Sequence=Displayed; Name=2; IsoId=Q9H0T7-2; Sequence=VSP_056400; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35292}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000250|UniProtKB:P35292}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35292}. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250|UniProtKB:P35292}.


uniprotID: O60671
geneSymbol: RAD1
reactome: R-HSA-176187;R-HSA-5685938;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;
pdb: 3A1J;3G65;3GGR;
length: 282
go: ENSG00000113456;
snps: rs2308951 rs41271673 rs1805328 rs2308957 rs1805327
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9716408}.
name:
Cell cycle checkpoint protein RAD1 (hRAD1) (EC 3.1.11.2) (DNA repair exonuclease rad1 homolog) (Rad1-like DNA damage checkpoint protein)

sequence:

opentargets:
checkpoint clamp complex [GO:0030896]; chromosome [GO:0005694]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; damaged DNA binding [GO:0003684]; exodeoxyribonuclease III activity [GO:0008853]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; meiotic recombination checkpoint [GO:0051598]; substantia nigra development [GO:0021762]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Hrad1A; IsoId=O60671-1; Sequence=Displayed; Name=2; Synonyms=Hrad1B; IsoId=O60671-2; Sequence=VSP_017334; Name=3; IsoId=O60671-3; Sequence=VSP_017335, VSP_017336; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q7Z5L2
geneSymbol: R3HCC1L
length: 792
go: ENSG00000166024;
snps: rs12775148 rs7922159 rs35373035 rs34494334 rs35122894 rs11189513 rs1952061
name:
Coiled-coil domain-containing protein R3HCC1L (Growth inhibition and differentiation-related protein 88) (Putative mitochondrial space protein 32.1) (R3H and coiled-coil domain-containing protein 1-like)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z5L2-1; Sequence=Displayed; Name=2; IsoId=Q7Z5L2-2; Sequence=VSP_014920; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z5L2-3; Sequence=VSP_014919, VSP_014921; 


uniprotID: Q96B01
geneSymbol: RAD51AP1
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;
name: RAD51-associated protein 1 (RAD51-interacting protein)
length: 352
go: ENSG00000111247;
snps: rs34810644
sequence:

opentargets:
nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; cellular response to ionizing radiation [GO:0071479]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; regulation of double-strand break repair via homologous recombination [GO:0010569]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist. {ECO:0000269|PubMed:9396801}; Name=1 {ECO:0000305}; IsoId=Q96B01-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:9396801}; IsoId=Q96B01-2; Sequence=VSP_051739; Name=3 {ECO:0000269|PubMed:9396801}; IsoId=Q96B01-3; Sequence=VSP_051740; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.


uniprotID: P61224
geneSymbol: RAP1B
pdb: 3BRW;3CF6;4DXA;4HDO;4HDQ;4M8N;4MGI;4MGK;4MGY;4MGZ;4MH0;5KHO;6AXF;6BA6;
name: Ras-related protein Rap-1b (GTP-binding protein smg p21B)
length: 184
go: ENSG00000127314;
reactome:
R-HSA-354192;R-HSA-354194;R-HSA-372708;R-HSA-392517;R-HSA-5674135;R-HSA-6798695;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802955;R-HSA-8875555;R-HSA-8950505;

sequence:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL

opentargets:
azurophil granule membrane [GO:0035577]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]; cell proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; cellular response to drug [GO:0035690]; cellular response to gonadotropin-releasing hormone [GO:0097211]; establishment of endothelial barrier [GO:0061028]; interleukin-12-mediated signaling pathway [GO:0035722]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; neutrophil degranulation [GO:0043312]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of establishment of cell polarity [GO:2000114]; response to carbohydrate [GO:0009743]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P61224-1; Sequence=Displayed; Name=2; IsoId=P61224-2; Sequence=VSP_045305; Name=3; IsoId=P61224-3; Sequence=VSP_045304; Name=4; IsoId=P61224-4; Sequence=VSP_045303; 

location:
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.


uniprotID: Q15907
geneSymbol: RAB11B
reactome: R-HSA-8854214;R-HSA-8873719;
pdb: 2F9L;2F9M;4OJK;
name: Ras-related protein Rab-11B (GTP-binding protein YPT3)
length: 218
go: ENSG00000185236;
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; cell junction [GO:0030054]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; cadherin binding [GO:0045296]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; cellular response to acidic pH [GO:0071468]; constitutive secretory pathway [GO:0045054]; establishment of protein localization to membrane [GO:0090150]; exocytosis [GO:0006887]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; post-translational protein modification [GO:0043687]; Rab protein signal transduction [GO:0032482]; receptor recycling [GO:0001881]; regulated exocytosis [GO:0045055]; regulation of anion transport [GO:0044070]; regulation of endocytic recycling [GO:2001135]; regulation of protein localization to cell surface [GO:2000008]; retrograde transport, endosome to plasma membrane [GO:1990126]; transcytosis [GO:0045056]; transferrin transport [GO:0033572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15907-1; Sequence=Displayed; Name=2; IsoId=Q15907-2; Sequence=VSP_055832; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305|PubMed:21255211}; Lipid-anchor {ECO:0000305|PubMed:21255211}; Cytoplasmic side {ECO:0000305|PubMed:21255211}. Note=Recruited to phagosomes containing S.aureus.


uniprotID: O60896
geneSymbol: RAMP3
reactome: R-HSA-418555;R-HSA-419812;
length: 148
go: ENSG00000122679;
drug: DB01278;
snps: rs10272187 rs11550711 rs2074654
name:
Receptor activity-modifying protein 3 (Calcitonin-receptor-like receptor activity-modifying protein 3) (CRLR activity-modifying protein 3)

sequence:
METGALRRPQLLPLLLLLCGGCPRAGGCNETGMLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKRTDTLL

opentargets:
adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 3 [GO:0150058]; cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adrenomedullin receptor activity [GO:0001605]; coreceptor activity [GO:0015026]; protein transporter activity [GO:0008565]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; calcium ion transport [GO:0006816]; cellular response to estradiol stimulus [GO:0071392]; cellular response to hormone stimulus [GO:0032870]; cross-receptor inhibition within G protein-coupled receptor heterodimer [GO:0038041]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway involved in heart process [GO:0086103]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion import across plasma membrane [GO:1905665]; positive regulation of cell death [GO:0010942]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of receptor recycling [GO:0001921]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000269|PubMed:23674134}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.


uniprotID: Q86U06
geneSymbol: RBM23
pdb: 2CQ4;2DNZ;
length: 439
go: ENSG00000100461;
snps: rs34246954 rs1127066
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Probable RNA-binding protein 23 (RNA-binding motif protein 23) (RNA-binding region-containing protein 4) (Splicing factor SF2)

sequence:

opentargets:
cytoplasmic stress granule [GO:0010494]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; U1 snRNP binding [GO:1990446]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; mRNA processing [GO:0006397]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q86U06-1; Sequence=Displayed; Name=2; IsoId=Q86U06-2; Sequence=VSP_008312; Name=3; IsoId=Q86U06-3; Sequence=VSP_008314, VSP_008315; Name=4; IsoId=Q86U06-4; Sequence=VSP_008312, VSP_008313; Name=5; IsoId=Q86U06-5; Sequence=VSP_008311; 


uniprotID: Q9NYR8
geneSymbol: RDH8
reactome: R-HSA-2453902;
length: 311
drug: DB00162;
snps: rs1122206 rs1644731
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; estradiol 17-beta-dehydrogenase activity [GO:0004303]; NADP-retinol dehydrogenase activity [GO:0052650]; retinol dehydrogenase activity [GO:0004745]; estrogen biosynthetic process [GO:0006703]; response to stimulus [GO:0050896]; steroid biosynthetic process [GO:0006694]; visual perception [GO:0007601]


uniprotID: O95072
geneSymbol: REC8
reactome: R-HSA-1221632;
name: Meiotic recombination protein REC8 homolog (Cohesin Rec8p)
length: 547
go: ENSG00000100918;
snps: rs34075659 rs35425516 rs17855369
sequence:

opentargets:
condensed nuclear chromosome kinetochore [GO:0000778]; lateral element [GO:0000800]; male germ cell nucleus [GO:0001673]; meiotic cohesin complex [GO:0030893]; nuclear meiotic cohesin complex [GO:0034991]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; fertilization [GO:0009566]; male meiosis I [GO:0007141]; meiotic cell cycle [GO:0051321]; oocyte maturation [GO:0001556]; reciprocal meiotic recombination [GO:0007131]; seminiferous tubule development [GO:0072520]; sister chromatid cohesion [GO:0007062]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95072-1; Sequence=Displayed; Name=2; IsoId=O95072-2; Sequence=VSP_037649; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome {ECO:0000250|UniProtKB:Q6AYJ4}. Chromosome, centromere {ECO:0000250|UniProtKB:Q6AYJ4}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II. Localised to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250|UniProtKB:Q6AYJ4}.


uniprotID: Q9H0Z9
geneSymbol: RBM38
pdb: 2CQD;
length: 239
go: ENSG00000132819;
snps: rs1065288 rs1065289 rs1065290 rs16980970
name:
RNA-binding protein 38 (CLL-associated antigen KW-5) (HSRNASEB) (RNA-binding motif protein 38) (RNA-binding region-containing protein 1) (ssDNA-binding protein SEB4)

sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cell cycle [GO:0007049]; cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; mRNA processing [GO:0006397]; negative regulation of cell proliferation [GO:0008285]; regulation of myotube differentiation [GO:0010830]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=RNPC1a; IsoId=Q9H0Z9-1; Sequence=Displayed; Name=2; Synonyms=RNPC1b; IsoId=Q9H0Z9-2; Sequence=VSP_035881; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17050675}. Nucleus {ECO:0000269|PubMed:17050675}.


uniprotID: Q6ZSC3
geneSymbol: RBM43
name: RNA-binding protein 43 (RNA-binding motif protein 43)
length: 357
go: ENSG00000184898;
opentargets: RNA binding [GO:0003723]
snps: rs35749426
sequence:


uniprotID: Q9Y5S9
geneSymbol: RBM8A
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;R-HSA-9010553;R-HSA-975957;
pdb: 1P27;2HYI;2J0Q;2J0S;2XB2;3EX7;5XJC;5YZG;
length: 174
go: ENSG00000265241;
name:
RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)

sequence:
MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEEGSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; exon-exon junction complex [GO:0035145]; neuronal cell body [GO:0043025]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of translation [GO:0006417]; RNA export from nucleus [GO:0006405]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=BOV-1a; IsoId=Q9Y5S9-1; Sequence=Displayed; Name=2; Synonyms=BOV-1b; IsoId=Q9Y5S9-2; Sequence=VSP_005810; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19324961}. Nucleus speckle {ECO:0000269|PubMed:19324961}. Cytoplasm {ECO:0000269|PubMed:19324961}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.


uniprotID: Q9H082
geneSymbol: RAB33B
reactome: R-HSA-6811438;R-HSA-8854214;R-HSA-8873719;
name: Ras-related protein Rab-33B
length: 229
go: ENSG00000172007;
snps: rs587776958 rs886044716
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; presynapse [GO:0098793]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; ER to Golgi vesicle-mediated transport [GO:0006888]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; negative regulation of constitutive secretory pathway [GO:1903434]; protein localization to Golgi apparatus [GO:0034067]; Rab protein signal transduction [GO:0032482]; regulation of Golgi organization [GO:1903358]; regulation of retrograde vesicle-mediated transport, Golgi to ER [GO:2000156]; skeletal system morphogenesis [GO:0048705]

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O35963}; Lipid-anchor {ECO:0000305}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18448665}. Note=Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm. {ECO:0000250|UniProtKB:O35963}.


uniprotID: Q5U651
geneSymbol: RASIP1
pdb: 5KHO;5KHQ;
name: Ras-interacting protein 1 (Rain)
length: 963
go: ENSG00000105538;
snps: rs2287922
sequence:

opentargets:
cell-cell junction [GO:0005911]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; GTPase binding [GO:0051020]; protein homodimerization activity [GO:0042803]; angiogenesis [GO:0001525]; branching morphogenesis of an epithelial tube [GO:0048754]; negative regulation of autophagy [GO:0010507]; negative regulation of membrane permeability [GO:1905709]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of Rho-dependent protein serine/threonine kinase activity [GO:2000299]; positive regulation of integrin activation [GO:0033625]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15031288}. Golgi apparatus, Golgi stack {ECO:0000269|PubMed:15031288}. Note=Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS.


uniprotID: Q9NW64
geneSymbol: RBM22
reactome: R-HSA-72163;
pdb: 2YTC;5MQF;5XJC;5YZG;5Z56;5Z57;6FF4;
length: 420
go: ENSG00000086589;
name:
Pre-mRNA-splicing factor RBM22 (RNA-binding motif protein 22) (Zinc finger CCCH domain-containing protein 16)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Prp19 complex [GO:0000974]; U2-type catalytic step 1 spliceosome [GO:0071006]; U2-type catalytic step 2 spliceosome [GO:0071007]; calcium-dependent protein binding [GO:0048306]; metal ion binding [GO:0046872]; pre-mRNA binding [GO:0036002]; RNA binding [GO:0003723]; U6 snRNA binding [GO:0017070]; cellular response to drug [GO:0035690]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of RNA splicing [GO:0033120]; protein import into nucleus, translocation [GO:0000060]; spliceosomal snRNP assembly [GO:0000387]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NW64-1; Sequence=Displayed; Name=2; IsoId=Q9NW64-2; Sequence=VSP_036832; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.


uniprotID: P25800
geneSymbol: LMO1
reactome: R-HSA-8939236;
length: 156
go: ENSG00000166407;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)

sequence:
MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYWHEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVMRARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDYEEGQLNGTFESQVQ

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of T cell homeostatic proliferation [GO:0046013]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P25800-1; Sequence=Displayed; Name=2; IsoId=P25800-2; Sequence=VSP_046664; Note=No experimental confirmation available.; 


uniprotID: Q8TC12
geneSymbol: RDH11
reactome: R-HSA-2453902;R-HSA-5365859;R-HSA-975634;
length: 318
go: ENSG00000072042;
drug: DB00162;
name:
Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; photoreceptor inner segment [GO:0001917]; NADP-retinol dehydrogenase activity [GO:0052650]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; retinol dehydrogenase activity [GO:0004745]; adaptation of rhodopsin mediated signaling [GO:0016062]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TC12-1; Sequence=Displayed; Name=2; IsoId=Q8TC12-2; Sequence=VSP_008159; Note=No experimental confirmation available.; Name=3; IsoId=Q8TC12-3; Sequence=VSP_046403; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12036956}; Single-pass type II membrane protein {ECO:0000269|PubMed:12036956}.


uniprotID: Q9P2K3
geneSymbol: RCOR3
pdb: 4CZZ;
name: REST corepressor 3
length: 495
go: ENSG00000117625;
snps: rs17856928
sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; transcriptional repressor complex [GO:0017053]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9P2K3-1; Sequence=Displayed; Name=2; IsoId=Q9P2K3-2; Sequence=VSP_017460, VSP_017461, VSP_017462; Note=No experimental confirmation available.; Name=3; IsoId=Q9P2K3-3; Sequence=VSP_017460; Note=No experimental confirmation available.; Name=4; IsoId=Q9P2K3-4; Sequence=VSP_017460, VSP_041465, VSP_041466; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.


uniprotID: Q9BTD8
geneSymbol: RBM42
name: RNA-binding protein 42 (RNA-binding motif protein 42)
length: 480
go: ENSG00000126254;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9BTD8-1; Sequence=Displayed; Name=2; Synonyms=RBM42a; IsoId=Q9BTD8-2; Sequence=VSP_028817; Name=3; IsoId=Q9BTD8-3; Sequence=VSP_028818; Name=4; Synonyms=RBM42b; IsoId=Q9BTD8-4; Sequence=VSP_037256; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Upon stress response, localizes with HNRNPK in cytoplasmic aggregates of stalled translational preinitiation complexes called stress granules. {ECO:0000250}.


uniprotID: Q7Z6P3
geneSymbol: RAB44
reactome: R-HSA-6798695;R-HSA-8873719;
name: Ras-related protein Rab-44
length: 1021
go: ENSG00000255587;
sequence:

opentargets:
azurophil granule membrane [GO:0035577]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; calcium ion binding [GO:0005509]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; Rab protein signal transduction [GO:0032482]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.


uniprotID: Q92928
geneSymbol: RAB1C
name: Putative Ras-related protein Rab-1C (hRab1c)
length: 201
location: SUBCELLULAR LOCATION: Membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
Golgi membrane [GO:0000139]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]


uniprotID: O14966
geneSymbol: RAB29
reactome: R-HSA-8873719;
name: Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29)
length: 203
go: ENSG00000117280;
sequence:

opentargets:
cis-Golgi network [GO:0005801]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; intracellular vesicle [GO:0097708]; melanosome [GO:0042470]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; symbiont-containing vacuole [GO:0020003]; trans-Golgi network [GO:0005802]; vacuole [GO:0005773]; dynein complex binding [GO:0070840]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; kinesin binding [GO:0019894]; Rab GTPase binding [GO:0017137]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; mitochondrion organization [GO:0007005]; multi-organism toxin transport [GO:1990967]; negative regulation of neuron projection development [GO:0010977]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of receptor recycling [GO:0001921]; positive regulation of T cell receptor signaling pathway [GO:0050862]; protein localization to ciliary membrane [GO:1903441]; protein localization to membrane [GO:0072657]; Rab protein signal transduction [GO:0032482]; regulation of neuron death [GO:1901214]; regulation of retrograde transport, endosome to Golgi [GO:1905279]; response to bacterium [GO:0009617]; retrograde transport, endosome to Golgi [GO:0042147]; synapse assembly [GO:0007416]; T cell activation [GO:0042110]; viral RNA genome replication [GO:0039694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O14966-1; Sequence=Displayed; Name=2; IsoId=O14966-2; Sequence=VSP_043391; Note=No experimental confirmation available.; Name=3; IsoId=O14966-3; Sequence=VSP_045078; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:24788816}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24788816}. Golgi apparatus {ECO:0000269|PubMed:22042847}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24788816}. Vacuole {ECO:0000269|PubMed:22042847}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22042847}. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (By similarity). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847). {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816}.


uniprotID: O75884
geneSymbol: RBBP9
pdb: 2QS9;
length: 186
go: ENSG00000089050;
name:
Putative hydrolase RBBP9 (EC 3.-.-.-) (B5T-overexpressed gene protein) (Protein BOG) (Retinoblastoma-binding protein 10) (RBBP-10) (Retinoblastoma-binding protein 9) (RBBP-9)

sequence:
MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; hydrolase activity [GO:0016787]; regulation of cell proliferation [GO:0042127]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75884-1; Sequence=Displayed; Name=2; IsoId=O75884-2; Sequence=VSP_004374; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12296629}. Nucleus {ECO:0000269|PubMed:12296629}.


uniprotID: P0DJD4
geneSymbol: RBMY1C
name: RNA-binding motif protein, Y chromosome, family 1 member C
length: 496
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9108067}.
sequence:

opentargets:
nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; U2 snRNP [GO:0005686]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; protein complex oligomerization [GO:0051259]; regulation of RNA splicing [GO:0043484]


uniprotID: P06400
geneSymbol: RB1
pdb: 1AD6;1GH6;1GUX;1H25;1N4M;1O9K;1PJM;2AZE;2QDJ;2R7G;3N5U;3POM;4CRI;4ELJ;4ELL;
name: Retinoblastoma-associated protein (p105-Rb) (pRb) (Rb) (pp110)
length: 928
go: ENSG00000139687;
drug: DB00030;DB00071;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20940255}.
reactome:
R-HSA-113501;R-HSA-2299718;R-HSA-2559584;R-HSA-2559585;R-HSA-69200;R-HSA-69202;R-HSA-69231;R-HSA-69656;R-HSA-8940973;

sequence:

opentargets:
chromatin [GO:0000785]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; Rb-E2F complex [GO:0035189]; spindle [GO:0005819]; SWI/SNF complex [GO:0016514]; transcription factor complex [GO:0005667]; androgen receptor binding [GO:0050681]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; importin-alpha family protein binding [GO:0061676]; kinase binding [GO:0019900]; phosphoprotein binding [GO:0051219]; proximal promoter sequence-specific DNA binding [GO:0000987]; RNA polymerase II activating transcription factor binding [GO:0001102]; RNA polymerase II regulatory region DNA binding [GO:0001012]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; ubiquitin protein ligase binding [GO:0031625]; androgen receptor signaling pathway [GO:0030521]; aortic valve morphogenesis [GO:0003180]; cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; cell division [GO:0051301]; cell morphogenesis involved in neuron differentiation [GO:0048667]; cellular response to xenobiotic stimulus [GO:0071466]; chromatin remodeling [GO:0006338]; digestive tract development [GO:0048565]; enucleate erythrocyte differentiation [GO:0043353]; G1/S transition of mitotic cell cycle [GO:0000082]; glial cell apoptotic process [GO:0034349]; hepatocyte apoptotic process [GO:0097284]; maintenance of mitotic sister chromatid cohesion [GO:0034088]; mitotic cell cycle checkpoint [GO:0007093]; myoblast differentiation [GO:0045445]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of smoothened signaling pathway [GO:0045879]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0071930]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]; neuron maturation [GO:0042551]; neuron projection development [GO:0031175]; positive regulation of collagen fibril organization [GO:1904028]; positive regulation of extracellular matrix organization [GO:1903055]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of mitotic metaphase/anaphase transition [GO:0045842]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription regulatory region DNA binding [GO:2000679]; positive regulation of transcription, DNA-templated [GO:0045893]; protein localization to chromosome, centromeric region [GO:0071459]; Ras protein signal transduction [GO:0007265]; regulation of cell growth [GO:0001558]; regulation of centromere complex assembly [GO:0090230]; regulation of cohesin loading [GO:0071922]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription, DNA-templated [GO:0006355]; sister chromatid biorientation [GO:0031134]; skeletal muscle cell differentiation [GO:0035914]; striated muscle cell differentiation [GO:0051146]; tissue homeostasis [GO:0001894]; viral process [GO:0016032]

snps:
rs3092900 rs3092902 rs200844292 rs767011440 rs4151534 rs4151539 rs1050717570 rs137853292 rs3092895 rs137853294 rs3092903 rs137853296 rs3092905 


uniprotID: Q5JT25
geneSymbol: RAB41
reactome: R-HSA-6811438;R-HSA-8873719;
name: Ras-related protein Rab-41
length: 222
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5JT25-1; Sequence=Displayed; Name=2; IsoId=Q5JT25-2; Sequence=VSP_037051; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23936529}. Note=punctate localization concentrated in ruffled regions at the cell periphery.


uniprotID: P51149
geneSymbol: RAB7A
reactome: R-HSA-2132295;R-HSA-6798695;R-HSA-8854214;R-HSA-8873719;R-HSA-8876198;
pdb: 1T91;1YHN;3LAW;
name: Ras-related protein Rab-7a
length: 207
go: ENSG00000075785;
drug: DB04315;
snps: rs11549759 rs121909078 rs121909081 rs121909080 rs121909079
sequence:

opentargets:
autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extrinsic component of lysosome membrane [GO:0032419]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; melanosome membrane [GO:0033162]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; vacuolar membrane [GO:0005774]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; retromer complex binding [GO:1905394]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; autophagosome assembly [GO:0000045]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome to lysosome transport [GO:0008333]; epidermal growth factor catabolic process [GO:0007174]; intracellular protein transport [GO:0006886]; lipid catabolic process [GO:0016042]; lipophagy [GO:0061724]; multi-organism intracellular transport [GO:1902583]; negative regulation of exosomal secretion [GO:1903542]; negative regulation of intralumenal vesicle formation [GO:1905366]; neutrophil degranulation [GO:0043312]; phagosome acidification [GO:0090383]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of viral process [GO:0048524]; protein targeting to lysosome [GO:0006622]; protein to membrane docking [GO:0022615]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]; viral release from host cell [GO:0019076]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:21255211}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:20028791}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:20028791}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:20028791}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lipid droplet {ECO:0000250|UniProtKB:P51150}. Endosome membrane {ECO:0000269|PubMed:22431521}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Recruited to phagosomes containing S.aureus or Mycobacterium (PubMed:21255211). Lipid droplet localization is increased upon ADRB2 stimulation (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211}.


uniprotID: P53805
geneSymbol: RCAN1
length: 252
go: ENSG00000159200;
name:
Calcipressin-1 (Adapt78) (Down syndrome critical region protein 1) (Myocyte-enriched calcineurin-interacting protein 1) (MCIP1) (Regulator of calcineurin 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; blood circulation [GO:0008015]; calcineurin-NFAT signaling cascade [GO:0033173]; central nervous system development [GO:0007417]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=CALP1-L {ECO:0000303|PubMed:12809556}; IsoId=P53805-1; Sequence=Displayed; Name=2; Synonyms=CALP1-S {ECO:0000303|PubMed:12809556}; IsoId=P53805-2; Sequence=VSP_001314; Name=3; IsoId=P53805-3; Sequence=VSP_001315; Name=4; IsoId=P53805-4; Sequence=VSP_001316; 


uniprotID: Q14257
geneSymbol: RCN2
name: Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP)
length: 317
go: ENSG00000117906;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; nucleolus [GO:0005730]; calcium ion binding [GO:0005509]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14257-1; Sequence=Displayed; Name=2; IsoId=Q14257-2; Sequence=VSP_055139; Note=Gene prediction based on EST data.; 


uniprotID: Q96D15
geneSymbol: RCN3
name: Reticulocalbin-3 (EF-hand calcium-binding protein RLP49)
length: 328
go: ENSG00000142552;
snps: rs34654230
location: SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16433634}.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; calcium ion binding [GO:0005509]; collagen biosynthetic process [GO:0032964]; ERAD pathway [GO:0036503]; lung epithelium development [GO:0060428]; phospholipid homeostasis [GO:0055091]; positive regulation of peptidase activity [GO:0010952]; protein secretion [GO:0009306]; protein transport [GO:0015031]; regulation of protein kinase B signaling [GO:0051896]; surfactant homeostasis [GO:0043129]


uniprotID: Q8TAI7
geneSymbol: RHEBL1
pdb: 3OES;
length: 183
go: ENSG00000167550;
name:
GTPase RhebL1 (Ras homolog enriched in brain like-1 c) (RhebL1c) (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) (Rheb2)

sequence:
MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNKADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRCHLM

opentargets:
cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; TOR signaling [GO:0031929]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TAI7-1; Sequence=Displayed; Name=2; IsoId=Q8TAI7-2; Sequence=VSP_040851, VSP_040852; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305|PubMed:16328882}; Lipid-anchor {ECO:0000305|PubMed:16006564}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16328882}.


uniprotID: B7ZAP0
geneSymbol: RABGAP1L
name: Rab GTPase-activating protein 1-like, isoform 10
length: 253
go: ENSG00000152061;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=10;  Name=10; Synonyms=D; IsoId=B7ZAP0-1; Sequence=Displayed; Name=1; IsoId=Q5R372-1; Sequence=External; Name=2; IsoId=Q5R372-2; Sequence=External; Name=3; IsoId=Q5R372-3; Sequence=External; Name=4; IsoId=Q5R372-4; Sequence=External; Name=5; IsoId=Q5R372-5; Sequence=External; Name=6; IsoId=Q5R372-6; Sequence=External; Name=7; IsoId=Q5R372-7; Sequence=External; Name=8; IsoId=Q5R372-8; Sequence=External; Name=9; IsoId=Q5R372-9; Sequence=External; 


uniprotID: Q96S21
geneSymbol: RAB40C
reactome: R-HSA-8873719;
length: 281
go: ENSG00000197562;
name:
Ras-related protein Rab-40C (Rar-like protein) (Ras-like protein family member 8C) (SOCS box-containing protein RAR3)

sequence:

opentargets:
Golgi membrane [GO:0000139]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; protein ubiquitination [GO:0016567]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96S21-1; Sequence=Displayed; Name=2; IsoId=Q96S21-2; Sequence=VSP_055835; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.


uniprotID: Q14206
geneSymbol: RCAN2
length: 197
go: ENSG00000172348;
name:
Calcipressin-2 (Down syndrome candidate region 1-like 1) (Myocyte-enriched calcineurin-interacting protein 2) (MCIP2) (Regulator of calcineurin 2) (Thyroid hormone-responsive protein ZAKI-4)

sequence:
MPAPSMDCDVSTLVACVVDVEVFTNQEVKEKFEGLFRTYDDCVTFQLFKSFRRVRINFSNPKSAARARIELHETQFRGKKLKLYFAQVQTPETDGDKLHLAPPQPAKQFLISPPSSPPVGWQPINDATPVLNYDLLYAVAKLGPGEKYELHAGTESTPSVVVHVCDSDIEEEEDPKTSPKPKIIQTRRPGLPPSVSN

opentargets:
cytoplasm [GO:0005737]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; nucleic acid binding [GO:0003676]; calcium-mediated signaling [GO:0019722]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=ZAKI-4 alpha; IsoId=Q14206-1; Sequence=Displayed; Name=2; Synonyms=ZAKI-4 beta; IsoId=Q14206-2; Sequence=VSP_026923; 


uniprotID: Q96T37
geneSymbol: RBM15
name: RNA-binding protein 15 (One-twenty two protein 1) (RNA-binding motif protein 15)
length: 977
go: ENSG00000162775;
sequence:

opentargets:
nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; branching involved in blood vessel morphogenesis [GO:0001569]; dosage compensation by inactivation of X chromosome [GO:0009048]; negative regulation of myeloid cell differentiation [GO:0045638]; placenta blood vessel development [GO:0060674]; positive regulation of transcription of Notch receptor target [GO:0007221]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of megakaryocyte differentiation [GO:0045652]; RNA methylation [GO:0001510]; spleen development [GO:0048536]; thrombopoietin-mediated signaling pathway [GO:0038163]; ventricular septum morphogenesis [GO:0060412]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=4;  Name=1; Synonyms=RBM15s+ae; IsoId=Q96T37-1; Sequence=Displayed; Name=2; Synonyms=RBM15L; IsoId=Q96T37-2; Sequence=VSP_005811; Name=3; Synonyms=RBM15S; IsoId=Q96T37-3; Sequence=VSP_005812; Name=4; IsoId=Q96T37-4; Sequence=VSP_053877, VSP_005811; Note=Produced by alternative initiation of isoform 2.; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19586903, ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17001072, ECO:0000269|PubMed:19786495, ECO:0000269|PubMed:24100041}. Nucleus envelope {ECO:0000269|PubMed:19586903}. Nucleus membrane {ECO:0000269|PubMed:19786495}; Peripheral membrane protein {ECO:0000269|PubMed:19786495}. Note=Colocalizes at the nuclear pore with DBP5 and NXF1. {ECO:0000269|PubMed:19786495}.


uniprotID: Q6ZP01
geneSymbol: RBM44
name: RNA-binding protein 44 (RNA-binding motif protein 44)
length: 1051
snps: rs13393001 rs13393001 rs10186505
sequence:

opentargets:
cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Detected in the intercellular bridges. {ECO:0000250}.


uniprotID: Q16576
geneSymbol: RBBP7
pdb: 3CFS;3CFV;
length: 425
go: ENSG00000102054;
location: SUBCELLULAR LOCATION: Nucleus.
reactome:
R-HSA-212300;R-HSA-2559580;R-HSA-3214815;R-HSA-3214841;R-HSA-3214847;R-HSA-3214858;R-HSA-427389;R-HSA-5617472;R-HSA-606279;R-HSA-6804758;R-HSA-73762;R-HSA-8943724;R-HSA-8951664;R-HSA-8953750;

name:
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)

sequence:

opentargets:
cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; histone deacetylase activity [GO:0004407]; RNA binding [GO:0003723]; cell proliferation [GO:0008283]; cellular heat acclimation [GO:0070370]; CENP-A containing nucleosome assembly [GO:0034080]; DNA replication [GO:0006260]; multicellular organism development [GO:0007275]; negative regulation of cell growth [GO:0030308]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of transcription by RNA polymerase II [GO:0000122]; post-translational protein modification [GO:0043687]; response to steroid hormone [GO:0048545]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q16576-1; Sequence=Displayed; Name=2; IsoId=Q16576-2; Sequence=VSP_043016; Note=No experimental confirmation available. {ECO:0000244|PubMed:20068231}; 


uniprotID: Q8TBY0
geneSymbol: RBM46
name: Probable RNA-binding protein 46 (Cancer/testis antigen 68) (CT68) (RNA-binding motif protein 46)
length: 533
go: ENSG00000151962;
sequence:

opentargets:
nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA stabilization [GO:0048255]; trophectodermal cell differentiation [GO:0001829]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TBY0-1; Sequence=Displayed; Name=2; IsoId=Q8TBY0-2; Sequence=VSP_055251; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBY0-3; Sequence=VSP_055252; Note=No experimental confirmation available.; 


uniprotID: C9J798
geneSymbol: RASA4B
name: Ras GTPase-activating protein 4B
length: 803
sequence:

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; cellular response to calcium ion [GO:0071277]; intracellular signal transduction [GO:0035556]; negative regulation of Ras protein signal transduction [GO:0046580]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43374}. Cell membrane {ECO:0000250|UniProtKB:O43374}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43374}.


uniprotID: Q96NR8
geneSymbol: RDH12
reactome: R-HSA-2453864;R-HSA-2453902;
length: 316
go: ENSG00000139988;
drug: DB00162;
name:
Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)

sequence:

opentargets:
intracellular [GO:0005622]; photoreceptor inner segment membrane [GO:0060342]; NADP-retinol dehydrogenase activity [GO:0052650]; retinol dehydrogenase activity [GO:0004745]; photoreceptor cell maintenance [GO:0045494]; response to stimulus [GO:0050896]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]

snps:
rs761231974 rs28940314 rs104894473 rs766631462 rs745471670 rs368489658 rs763414313 rs28940315 rs148334092 rs202126574 rs907600014 rs104894475 rs104894475 rs121434337 rs17852293 rs104894472 rs148629905 rs28940313 rs104894476 rs750636662 rs751589863 rs973306929 


uniprotID: Q8NBN7
geneSymbol: RDH13
reactome: R-HSA-5365859;
name: Retinol dehydrogenase 13 (EC 1.1.1.-) (Short chain dehydrogenase/reductase family 7C member 3)
length: 331
go: ENSG00000160439;
drug: DB00162;
sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; NADP-retinol dehydrogenase activity [GO:0052650]; eye photoreceptor cell development [GO:0042462]; response to high light intensity [GO:0009644]; retina layer formation [GO:0010842]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NBN7-1; Sequence=Displayed; Name=2; IsoId=Q8NBN7-2; Sequence=VSP_040383; 


uniprotID: Q96EV2
geneSymbol: RBM33
name: RNA-binding protein 33 (Proline-rich protein 8) (RNA-binding motif protein 33)
length: 1170
go: ENSG00000184863;
opentargets: RNA binding [GO:0003723]
snps: rs3735576
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96EV2-1; Sequence=Displayed; Name=2; IsoId=Q96EV2-2; Sequence=VSP_030143, VSP_030144; 


uniprotID: Q5T6V5
geneSymbol: C9orf64
name: Queuosine salvage protein
length: 341
go: ENSG00000165118;
opentargets: tRNA-guanine transglycosylation [GO:0101030]
sequence:


uniprotID: B2RC85
geneSymbol: RSPH10B2
name: Radial spoke head 10 homolog B2
length: 870
go: ENSG00000155026;ENSG00000169402;
snps: rs17855578
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=B2RC85-1; Sequence=Displayed; Name=2; IsoId=B2RC85-2; Sequence=VSP_035277, VSP_035278, VSP_035279; 


uniprotID: Q8TDY2
geneSymbol: RB1CC1
reactome: R-HSA-1632852;
name: RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)
length: 1594
go: ENSG00000023287;
snps: rs17337252 rs34016926 rs35534432 rs34701924 rs35342973 rs113117391
sequence:

opentargets:
Atg1/ULK1 kinase complex [GO:1990316]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of membrane [GO:0019898]; nuclear membrane [GO:0031965]; phagophore assembly site membrane [GO:0034045]; protein kinase binding [GO:0019901]; protein-containing complex scaffold activity [GO:0032947]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; autophagy of peroxisome [GO:0030242]; cell cycle [GO:0007049]; glycophagy [GO:0061723]; heart development [GO:0007507]; liver development [GO:0001889]; macroautophagy [GO:0016236]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; piecemeal microautophagy of the nucleus [GO:0034727]; positive regulation of cell size [GO:0045793]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein phosphorylation [GO:0001934]; regulation of macroautophagy [GO:0016241]; reticulophagy [GO:0061709]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TDY2-1; Sequence=Displayed; Name=2; IsoId=Q8TDY2-2; Sequence=VSP_040097; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11850849}. Cytoplasm {ECO:0000269|PubMed:10769033}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ESK9}. Preautophagosomal structure {ECO:0000250|UniProtKB:Q9ESK9}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250|UniProtKB:Q9ESK9}.


uniprotID: Q9BWF3
geneSymbol: RBM4
reactome: R-HSA-400253;
pdb: 2DNQ;
length: 364
go: ENSG00000173933;
name:
RNA-binding protein 4 (Lark homolog) (hLark) (RNA-binding motif protein 4) (RNA-binding motif protein 4a)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cyclin binding [GO:0030332]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; pre-mRNA intronic binding [GO:0097157]; pre-mRNA intronic pyrimidine-rich binding [GO:0097158]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cap-independent translational initiation [GO:0002190]; cell differentiation [GO:0030154]; circadian regulation of translation [GO:0097167]; entrainment of circadian clock by photoperiod [GO:0043153]; IRES-dependent translational initiation of linear mRNA [GO:0002192]; miRNA mediated inhibition of translation [GO:0035278]; mRNA cis splicing, via spliceosome [GO:0045292]; negative regulation of translation [GO:0017148]; negative regulation of translation in response to stress [GO:0032055]; negative regulation of translational initiation [GO:0045947]; positive regulation of muscle cell differentiation [GO:0051149]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of nucleocytoplasmic transport [GO:0046822]; response to arsenic-containing substance [GO:0046685]; RNA processing [GO:0006396]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9BWF3-1; Sequence=Displayed; Name=2; IsoId=Q9BWF3-2; Sequence=VSP_013414, VSP_013416; Note=May be due to an intron retention.; Name=3; IsoId=Q9BWF3-3; Sequence=VSP_013413, VSP_013415; Note=May be due to exon skipping.; Name=4; IsoId=Q9BWF3-4; Sequence=VSP_044493; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Nucleus speckle. Cytoplasm. Cytoplasmic granule. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation.


uniprotID: P18754
geneSymbol: RCC1
reactome: R-HSA-165054;R-HSA-180746;
pdb: 1A12;1I2M;5E1B;5E1D;5E1M;5E1O;5E2A;5E2B;5TBK;
length: 421
go: ENSG00000180198;
name:
Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)

sequence:

opentargets:
chromatin [GO:0000785]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; nuclear chromatin [GO:0000790]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; nucleosomal DNA binding [GO:0031492]; nucleosome binding [GO:0031491]; protein heterodimerization activity [GO:0046982]; Ran GTPase binding [GO:0008536]; Ran guanyl-nucleotide exchange factor activity [GO:0005087]; sulfate binding [GO:0043199]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; G1/S transition of mitotic cell cycle [GO:0000082]; mitotic spindle organization [GO:0007052]; protein heterotetramerization [GO:0051290]; regulation of mitotic nuclear division [GO:0007088]; spindle assembly [GO:0051225]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P18754-1; Sequence=Displayed; Name=2; Synonyms=RCC1-I; IsoId=P18754-2; Sequence=VSP_041122; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:16820410, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:2236072}. Chromosome {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580, ECO:0000269|PubMed:20668449}. Cytoplasm {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:20668449}. Note=Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). {ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:20668449}.


uniprotID: Q69383
geneSymbol: ERVK-6
length: 105
name:
Endogenous retrovirus group K member 6 Rec protein (Central open reading frame) (c-orf) (cORF) (Endogenous retrovirus K protein 6) (HERV-K(C7) Rec protein) (HERV-K(HML-2.HOM) Rec protein) (HERV-K108 Rec protein) (HERV-K_7p22.1 provirus Rec protein) (K-Rev) (Rev-like protein) (Rev/Rex homolog)

sequence:
MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGVPNSSEETATIENGP

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; protein-containing complex [GO:0032991]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; mRNA export from nucleus [GO:0006406]; positive regulation of gene expression [GO:0010628]; protein homooligomerization [GO:0051260]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus.


uniprotID: P42696
geneSymbol: RBM34
name: RNA-binding protein 34 (RNA-binding motif protein 34)
length: 430
go: ENSG00000188739;
opentargets: nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P42696-1; Sequence=Displayed; Name=2; IsoId=P42696-2; Sequence=VSP_037037, VSP_037038; Note=May be due to an intron retention.; 


uniprotID: P0DJD3
geneSymbol: RBMY1A1
pdb: 2FY1;
length: 496
go: ENSG00000234414;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9108067}.
name:
RNA-binding motif protein, Y chromosome, family 1 member A1 (RNA-binding motif protein 1) (RNA-binding motif protein 2) (Y chromosome RNA recognition motif 1) (hRBMY)

sequence:

opentargets:
nucleus [GO:0005634]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA cis splicing, via spliceosome [GO:0045292]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P0DJD3-1; Sequence=Displayed; Name=2; IsoId=P0DJD3-2; Sequence=VSP_042316; Name=3; IsoId=P0DJD3-3; Sequence=VSP_042315; 


uniprotID: P22891
geneSymbol: PROZ
reactome: R-HSA-159740;R-HSA-159763;R-HSA-159782;
pdb: 3F1S;3H5C;
name: Vitamin K-dependent protein Z
length: 400
go: ENSG00000126231;
drug: DB00170;
snps: rs3024778 rs3024772
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; calcium ion binding [GO:0005509]; serine-type endopeptidase activity [GO:0004252]; blood coagulation [GO:0007596]; ER to Golgi vesicle-mediated transport [GO:0006888]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P22891-1; Sequence=Displayed; Name=2; IsoId=P22891-2; Sequence=VSP_005415; 


uniprotID: Q00577
geneSymbol: PURA
name: Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)
length: 322
go: ENSG00000185129;
snps: rs587782999 rs587782994 rs587782995 rs587782998 rs587783001 rs786204834
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
dendrite cytoplasm [GO:0032839]; DNA replication factor A complex [GO:0005662]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; nuclear chromosome, telomeric region [GO:0000784]; nucleus [GO:0005634]; postsynapse [GO:0098794]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; double-stranded telomeric DNA binding [GO:0003691]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; single-stranded DNA binding [GO:0003697]; SMAD binding [GO:0046332]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; transcription factor binding [GO:0008134]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; cell differentiation [GO:0030154]; dendritic transport of messenger ribonucleoprotein complex [GO:0098963]; DNA replication initiation [GO:0006270]; DNA unwinding involved in DNA replication [GO:0006268]; nervous system development [GO:0007399]; positive regulation of cell proliferation [GO:0008284]


uniprotID: Q92626
geneSymbol: PXDN
reactome: R-HSA-2243919;
length: 1479
go: ENSG00000130508;
snps: rs587777572 rs6723697 rs6723697
name:
Peroxidasin homolog (EC 1.11.1.7) (Melanoma-associated antigen MG50) (Vascular peroxidase 1) (p53-responsive gene 2 protein)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; heme binding [GO:0020037]; interleukin-1 receptor antagonist activity [GO:0005152]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; extracellular matrix organization [GO:0030198]; hydrogen peroxide catabolic process [GO:0042744]; immune response [GO:0006955]; oxidation-reduction process [GO:0055114]; response to oxidative stress [GO:0006979]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q92626-1; Sequence=Displayed; Name=2; IsoId=Q92626-2; Sequence=VSP_031516, VSP_031517; 

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:19590037, ECO:0000269|Ref.8}. Note=Enriched in the peritubular space of fibrotic kidneys.


uniprotID: Q7RTV5
geneSymbol: PRXL2C
length: 226
go: ENSG00000158122;
opentargets: antioxidant activity [GO:0016209]; oxidation-reduction process [GO:0055114]
snps: rs9886834
name:
Peroxiredoxin-like 2C (AhpC/TSA antioxidant enzyme domain-containing protein 1) (Thioredoxin-like protein AAED1)

sequence:


uniprotID: A6NJB7
geneSymbol: PRR19
name: Proline-rich protein 19
length: 356
go: ENSG00000188368;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NJB7-1; Sequence=Displayed; Name=2; IsoId=A6NJB7-2; Sequence=VSP_033371; 


uniprotID: A0A1B0GVH4
geneSymbol: PRSS51
name: Serine protease-like protein 51
length: 220
go: ENSG00000253649;
opentargets: extracellular region [GO:0005576]; serine-type endopeptidase activity [GO:0004252]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:


uniprotID: O75360
geneSymbol: PROP1
name: Homeobox protein prophet of Pit-1 (PROP-1) (Pituitary-specific homeodomain factor)
length: 226
go: ENSG00000175325;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; beta-catenin binding [GO:0008013]; chromatin binding [GO:0003682]; distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001205]; distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001206]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein C-terminus binding [GO:0008022]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; blood vessel development [GO:0001568]; canonical Wnt signaling pathway [GO:0060070]; cell migration [GO:0016477]; central nervous system development [GO:0007417]; dorsal/ventral pattern formation [GO:0009953]; hypophysis morphogenesis [GO:0048850]; hypothalamus cell differentiation [GO:0021979]; negative regulation of apoptotic process [GO:0043066]; somatotropin secreting cell differentiation [GO:0060126]

snps:
rs7445271 rs121917843 rs121917842 rs121917841 rs137853100 rs121917840 rs121917839 rs146918863 rs1800197 


uniprotID: P0CG20
geneSymbol: PRR35
name: Proline-rich protein 35 (Uncharacterized protein RJD1)
length: 571
go: ENSG00000161992;
sequence:


uniprotID: Q9H6K5
geneSymbol: PRR36
name: Proline-rich protein 36
length: 1346
go: ENSG00000183248;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H6K5-1; Sequence=Displayed; Name=2; IsoId=Q9H6K5-2; Sequence=VSP_057467; 


uniprotID: Q7Z6L0
geneSymbol: PRRT2
name: Proline-rich transmembrane protein 2 (Dispanin subfamily B member 3) (DSPB3)
length: 340
go: ENSG00000167371;
sequence:

opentargets:
axon terminus [GO:0043679]; cell junction [GO:0030054]; dendritic spine [GO:0043197]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynapse [GO:0098793]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; vesicle [GO:0031982]; syntaxin-1 binding [GO:0017075]; negative regulation of short-term synaptic potentiation [GO:1905513]; negative regulation of SNARE complex assembly [GO:0035544]; neuromuscular process controlling posture [GO:0050884]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]

snps:
rs79182085 rs79568162 rs745594874 rs200926711 rs76335820 rs199556853 rs387907126 rs754897123 rs387907128 rs767799831 rs932713001 rs387907125 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z6L0-1; Sequence=Displayed; Name=2; IsoId=Q7Z6L0-2; Sequence=VSP_028815; Name=3; IsoId=Q7Z6L0-3; Sequence=VSP_028814; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22101681, ECO:0000269|PubMed:25915028, ECO:0000269|PubMed:27172900}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:E9PUL5}. Cell junction, synapse {ECO:0000250|UniProtKB:E9PUL5}. Cell projection, axon {ECO:0000269|PubMed:22832103}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D3ZFB6}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:D3ZFB6}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:D3ZFB6}.


uniprotID: P17980
geneSymbol: PSMC3
length: 439
go: ENSG00000165916;
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-6798695;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

pdb:
5GJQ;5GJR;5L4G;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHJ;5VHM;5VHN;5VHO;5VHP;5VHQ;5VHR;5VHS;

name:
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; identical protein binding [GO:0042802]; proteasome-activating ATPase activity [GO:0036402]; blastocyst development [GO:0001824]; modulation by host of viral transcription [GO:0043921]; neutrophil degranulation [GO:0043312]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-translational protein modification [GO:0043687]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250|UniProtKB:O88685}.


uniprotID: Q6UWB4
geneSymbol: PRSS55
name: Serine protease 55 (EC 3.4.21.-) (Testis serine protease 1) (T-SP1)
length: 352
go: ENSG00000184647;
snps: rs4521726 rs4406360
sequence:

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; serine-type endopeptidase activity [GO:0004252]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q6UWB4-1; Sequence=Displayed; Name=2; IsoId=Q6UWB4-2; Sequence=VSP_044557; 

location:
SUBCELLULAR LOCATION: Isoform 1: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytosol.


uniprotID: P27918
geneSymbol: CFP
reactome: R-HSA-173736;R-HSA-174577;R-HSA-5083635;R-HSA-5173214;R-HSA-6798695;R-HSA-977606;
pdb: 1W0R;1W0S;
name: Properdin (Complement factor P)
length: 469
go: ENSG00000126759;
snps: rs8177068 rs132630259 rs8177076 rs8177077 rs28935480 rs132630261
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; serine-type endopeptidase activity [GO:0004252]; complement activation [GO:0006956]; complement activation, alternative pathway [GO:0006957]; defense response to bacterium [GO:0042742]; immune response [GO:0006955]; neutrophil degranulation [GO:0043312]; regulation of complement activation [GO:0030449]


uniprotID: Q99946
geneSymbol: PRRT1
name: Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1)
length: 306
go: ENSG00000204314;
sequence:

opentargets:
cell junction [GO:0030054]; glutamatergic synapse [GO:0098978]; integral component of postsynaptic membrane [GO:0099055]; membrane [GO:0016020]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99946-1; Sequence=Displayed; Name=2; IsoId=Q99946-2; Sequence=VSP_003808; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}.


uniprotID: A0A1B0GWB2
geneSymbol: PRRT1B
name: Proline rich transmembrane protein 1B
length: 263
opentargets: integral component of membrane [GO:0016021]; membrane [GO:0016020]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: Q9UKY0
geneSymbol: PRND
reactome: R-HSA-163125;
pdb: 1LG4;
name: Prion-like protein doppel (PrPLP) (Prion protein 2)
length: 176
go: ENSG00000171864;
snps: rs35453518 rs2245220
sequence:
MRKHLSWWWLATVCMLLFSHLSAVQTRGIKHRIKWNRKALPSTAQITEAQVAENRPGAFIKQGRKLDIDFGAEGNRYYEANYWQFPDGIHYNGCSEANVTKEAFVTGCINATQAANQGEFQKPDNKLHQQVLWRLVQELCSLKHCEFWLERGAGLRVTMHQPVLLCLLALIWLTVK

opentargets:
anchored component of external side of plasma membrane [GO:0031362]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; copper ion binding [GO:0005507]; acrosome reaction [GO:0007340]; cellular copper ion homeostasis [GO:0006878]; protein homooligomerization [GO:0051260]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12200435, ECO:0000269|PubMed:15218028}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12200435}.


uniprotID: Q96M27
geneSymbol: PRRC1
name: Protein PRRC1 (Proline-rich and coiled-coil-containing protein 1)
length: 445
go: ENSG00000164244;
opentargets: Golgi apparatus [GO:0005794]
location: SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:15541471}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96M27-1; Sequence=Displayed; Name=2; IsoId=Q96M27-2; Sequence=VSP_028724; Note=Non-canonical splice sites for exon 9 and exon 10.; Name=3; IsoId=Q96M27-3; Sequence=VSP_028725; Name=4; IsoId=Q96M27-4; Sequence=VSP_028720, VSP_028721; Name=5; IsoId=Q96M27-5; Sequence=VSP_028722, VSP_028723; Note=No experimental confirmation available.; 


uniprotID: C9JH25
geneSymbol: PRRT4
name: Proline-rich transmembrane protein 4
length: 899
go: ENSG00000224940;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=C9JH25-1; Sequence=Displayed; Name=2; IsoId=C9JH25-2; Sequence=VSP_039273, VSP_039275; Note=No experimental confirmation available.; Name=3; IsoId=C9JH25-3; Sequence=VSP_039274; Note=No experimental confirmation available.; 


uniprotID: O43490
geneSymbol: PROM1
name: Prominin-1 (Antigen AC133) (Prominin-like protein 1) (CD antigen CD133)
length: 865
go: ENSG00000007062;
snps: rs137853006
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cilium [GO:0005929]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; microvillus [GO:0005902]; microvillus membrane [GO:0031528]; photoreceptor outer segment [GO:0001750]; photoreceptor outer segment membrane [GO:0042622]; plasma membrane [GO:0005886]; prominosome [GO:0071914]; vesicle [GO:0031982]; actinin binding [GO:0042805]; cadherin binding [GO:0045296]; cholesterol binding [GO:0015485]; camera-type eye photoreceptor cell differentiation [GO:0060219]; glomerular parietal epithelial cell differentiation [GO:0072139]; glomerular visceral epithelial cell differentiation [GO:0072112]; photoreceptor cell maintenance [GO:0045494]; positive regulation of nephron tubule epithelial cell differentiation [GO:2000768]; retina layer formation [GO:0010842]; retina morphogenesis in camera-type eye [GO:0060042]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=AC133-1, S2; IsoId=O43490-1; Sequence=Displayed; Name=2; Synonyms=AC133-2, S1; IsoId=O43490-2; Sequence=VSP_039069; Name=3; Synonyms=S3; IsoId=O43490-3; Sequence=VSP_040000, VSP_040002, VSP_040004; Name=4; Synonyms=S10; IsoId=O43490-4; Sequence=VSP_040000, VSP_040003; Name=5; Synonyms=S7; IsoId=O43490-5; Sequence=VSP_040000, VSP_040001; Name=6; Synonyms=S11; IsoId=O43490-6; Sequence=VSP_040001; Name=7; Synonyms=S12; IsoId=O43490-7; Sequence=VSP_040003; 

location:
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Endoplasmic reticulum. Endoplasmic reticulum-Golgi intermediate compartment. Note=Found in extracellular membrane particles in various body fluids such as cerebrospinal fluid, saliva, seminal fluid and urine.


uniprotID: P35080
geneSymbol: PFN2
reactome: R-HSA-376176;R-HSA-5663220;
pdb: 1D1J;
name: Profilin-2 (Profilin II)
length: 140
go: ENSG00000070087;
drug: DB02580;DB02078;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
sequence:
MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVHGGGLNKKAYSMAKYLRDSGF

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; postsynapse [GO:0098794]; presynapse [GO:0098793]; Schaffer collateral - CA1 synapse [GO:0098685]; actin binding [GO:0003779]; actin monomer binding [GO:0003785]; ATPase activity [GO:0016887]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; actin cytoskeleton organization [GO:0030036]; modification of postsynaptic actin cytoskeleton [GO:0098885]; negative regulation of actin filament polymerization [GO:0030837]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of ATPase activity [GO:0032781]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of stress fiber assembly [GO:0051496]; protein stabilization [GO:0050821]; regulation of actin filament polymerization [GO:0030833]; regulation of synaptic vesicle exocytosis [GO:2000300]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=IIa; IsoId=P35080-1; Sequence=Displayed; Name=IIb; IsoId=P35080-2; Sequence=VSP_005217; 


uniprotID: P0CW18
geneSymbol: PRSS56
name: Serine protease 56 (EC 3.4.21.-)
length: 603
go: ENSG00000237412;
snps: rs387907096 rs730882160 rs74703359 rs387907095 rs730882158 rs730882161 rs61744404
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; serine-type endopeptidase activity [GO:0004252]; camera-type eye development [GO:0043010]; proteolysis [GO:0006508]


uniprotID: A0A1B0GWK0
geneSymbol: PVALEF
name: Parvalbumin-like EF-hand-containing protein
length: 134
sequence:
MEEDFSSQMKKMALAMGTSLSDKDIELLPTDMRHHGSFNYLKFFKHIRKLHASGQLDDAIHTAFQSLDKDKSGFIEWNEIKYILSIIPSSGPTTPLTDEEAEAMIQAADTHGDGRINYEEFSELIKKEKIPKKK

opentargets:
troponin complex [GO:0005861]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; regulation of muscle contraction [GO:0006937]; skeletal muscle contraction [GO:0003009]


uniprotID: Q9Y6I8
geneSymbol: PXMP4
name: Peroxisomal membrane protein 4 (24 kDa peroxisomal intrinsic membrane protein)
length: 212
go: ENSG00000101417;
snps: rs910397
location: SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y6I8-1; Sequence=Displayed; Name=2; IsoId=Q9Y6I8-2; Sequence=VSP_041217, VSP_041218; 


uniprotID: Q6UX71
geneSymbol: PLXDC2
name: Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein)
length: 529
go: ENSG00000120594;
opentargets: integral component of membrane [GO:0016021]
snps: rs3817405 rs2778979
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6UX71-1; Sequence=Displayed; Name=2; IsoId=Q6UX71-2; Sequence=VSP_018378; Name=3; IsoId=Q6UX71-3; Sequence=VSP_018377; 


uniprotID: Q5TGL8
geneSymbol: PXDC1
name: PX domain-containing protein 1
length: 231
go: ENSG00000168994;
opentargets: phosphatidylinositol binding [GO:0035091]
snps: rs226959 rs17855666 rs368727869
sequence:


uniprotID: P17812
geneSymbol: CTPS1
reactome: R-HSA-499943;
pdb: 2VO1;5U03;
name: CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)
length: 591
go: ENSG00000171793;
drug: DB00130;
snps: rs17856308
sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; identical protein binding [GO:0042802]; 'de novo' CTP biosynthetic process [GO:0044210]; B cell proliferation [GO:0042100]; CTP biosynthetic process [GO:0006241]; glutamine metabolic process [GO:0006541]; nucleobase-containing compound metabolic process [GO:0006139]; nucleobase-containing small molecule interconversion [GO:0015949]; response to drug [GO:0042493]; T cell proliferation [GO:0042098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P17812-1; Sequence=Displayed; Name=2; IsoId=P17812-2; Sequence=VSP_055827; Note=No experimental confirmation available.; 


uniprotID: Q2L4Q9
geneSymbol: PRSS53
name: Serine protease 53 (EC 3.4.21.-) (Polyserine protease 3) (Polyserase-3)
length: 553
go: ENSG00000151006;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16566820}.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; serine-type endopeptidase activity [GO:0004252]


uniprotID: P0C7W0
geneSymbol: PRR29
name: Proline-rich protein 29
length: 189
go: ENSG00000224383;
snps: rs62070903
sequence:
MASGAGGSWGRSPPQSAVPTPWVTFLQPLSWAVPPAPPQPGRVKEDLLELMMLQNAQMHQLLLSRLVAGALQPRPASPCPQVYLEVPQEEPEEEEEEMDVREKGPLVFHHHYLPYLMPSPGALLPWPAPFFPTPACQPYLQDVPRIQHCPASREREVRAVPPPPPPSATGTVGADVPPASDYYDAESLL

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P0C7W0-1; Sequence=Displayed; Name=2; IsoId=P0C7W0-2; Sequence=VSP_045346; Note=No experimental confirmation available.; Name=3; IsoId=P0C7W0-3; Sequence=VSP_045344, VSP_045345; Note=No experimental confirmation available.; Name=4; IsoId=P0C7W0-4; Sequence=VSP_046997; Note=No experimental confirmation available.; 


uniprotID: P81277
geneSymbol: PRLH
reactome: R-HSA-375276;
sequence: MKVLRAWLLCLLMLGLALRGAASRTHRHSMEIRTPDINPAWYASRGIRPVGRFGRRRATLGDVPKPGLRPRLTCFPLEGGAMSSQDG
length: 87
go: ENSG00000071677;
location: SUBCELLULAR LOCATION: Secreted.
name:
Prolactin-releasing peptide (PrRP) (Prolactin-releasing hormone) [Cleaved into: Prolactin-releasing peptide PrRP31; Prolactin-releasing peptide PrRP20]

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; prolactin-releasing peptide receptor binding [GO:0031861]; autonomic nervous system development [GO:0048483]; energy reserve metabolic process [GO:0006112]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; lipid metabolic process [GO:0006629]; reduction of food intake in response to dietary excess [GO:0002023]; regulation of multicellular organism growth [GO:0040014]; response to glucose [GO:0009749]; response to insulin [GO:0032868]; tissue homeostasis [GO:0001894]


uniprotID: P62195
geneSymbol: PSMC5
length: 406
go: ENSG00000087191;
snps: rs11543211
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

pdb:
2KRK;3KW6;5GJQ;5GJR;5L4G;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHJ;5VHM;5VHN;5VHO;5VHP;5VHQ;5VHR;5VHS;

name:
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)

sequence:

opentargets:
blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; cytosolic proteasome complex [GO:0031597]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; membrane [GO:0016020]; nuclear proteasome complex [GO:0031595]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynapse [GO:0098794]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; proteasome-activating ATPase activity [GO:0036402]; TBP-class protein binding [GO:0017025]; thyrotropin-releasing hormone receptor binding [GO:0031531]; transcription factor binding [GO:0008134]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of transcription, DNA-templated [GO:0045893]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P62195-1; Sequence=Displayed; Name=2; IsoId=P62195-2; Sequence=VSP_045441; 


uniprotID: P11908
geneSymbol: PRPS2
reactome: R-HSA-73843;
length: 318
go: ENSG00000101911;
name:
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)

sequence:

opentargets:
cytoplasm [GO:0005737]; ribose phosphate diphosphokinase complex [GO:0002189]; ADP binding [GO:0043531]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; carbohydrate binding [GO:0030246]; GDP binding [GO:0019003]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; ribose phosphate diphosphokinase activity [GO:0004749]; 5-phosphoribose 1-diphosphate biosynthetic process [GO:0006015]; AMP biosynthetic process [GO:0006167]; animal organ regeneration [GO:0031100]; nucleobase-containing compound metabolic process [GO:0006139]; nucleoside metabolic process [GO:0009116]; nucleotide biosynthetic process [GO:0009165]; purine nucleotide biosynthetic process [GO:0006164]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P11908-1; Sequence=Displayed; Name=2; IsoId=P11908-2; Sequence=VSP_027769; Note=No experimental confirmation available.; 


uniprotID: A4D1T9
geneSymbol: PRSS37
name: Probable inactive serine protease 37 (Probable inactive trypsin-X2)
length: 235
go: ENSG00000165076;
snps: rs12669721
sequence:

opentargets:
acrosomal vesicle [GO:0001669]; extracellular region [GO:0005576]; nucleus [GO:0005634]; secretory granule [GO:0030141]; serine-type endopeptidase activity [GO:0004252]; binding of sperm to zona pellucida [GO:0007339]; cell migration [GO:0016477]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of fertilization [GO:1905516]; protein maturation [GO:0051604]; regulation of protein processing [GO:0070613]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27649891}. Secreted {ECO:0000305}.


uniprotID: P54821
geneSymbol: PRRX1
length: 245
go: ENSG00000116132;
snps: rs387906667
location: SUBCELLULAR LOCATION: Nucleus.
name:
Paired mesoderm homeobox protein 1 (Homeobox protein PHOX1) (Paired-related homeobox protein 1) (PRX-1)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; HMG box domain binding [GO:0071837]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; artery morphogenesis [GO:0048844]; cartilage development [GO:0051216]; embryonic cranial skeleton morphogenesis [GO:0048701]; embryonic limb morphogenesis [GO:0030326]; inner ear morphogenesis [GO:0042472]; middle ear morphogenesis [GO:0042474]; neuron fate determination [GO:0048664]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of smoothened signaling pathway [GO:0045880]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of neuron projection regeneration [GO:0070570]; roof of mouth development [GO:0060021]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=PMX1-B; IsoId=P54821-1; Sequence=Displayed; Name=2; Synonyms=PMX1-A; IsoId=P54821-2; Sequence=VSP_002278; 


uniprotID: Q9UJV8
geneSymbol: PURG
name: Purine-rich element-binding protein gamma (Purine-rich element-binding protein G)
length: 347
go: ENSG00000172733;
snps: rs11574153 rs7464560 rs11574151
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; purine-rich negative regulatory element binding [GO:0032422]; RNA binding [GO:0003723]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=PURG-A; IsoId=Q9UJV8-1; Sequence=Displayed; Name=2; Synonyms=PURG-B; IsoId=Q9UJV8-2; Sequence=VSP_021319; 


uniprotID: O75192
geneSymbol: PEX11A
reactome: R-HSA-1989781;
length: 247
go: ENSG00000166821;
name:
Peroxisomal membrane protein 11A (HsPEX11p) (28 kDa peroxisomal integral membrane protein) (PMP28) (Peroxin-11A) (Peroxisomal biogenesis factor 11A) (Protein PEX11 homolog alpha) (PEX11-alpha)

sequence:

opentargets:
integral component of peroxisomal membrane [GO:0005779]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; protein homodimerization activity [GO:0042803]; brown fat cell differentiation [GO:0050873]; peroxisome fission [GO:0016559]; peroxisome membrane biogenesis [GO:0016557]; peroxisome organization [GO:0007031]; regulation of lipid metabolic process [GO:0019216]; regulation of peroxisome size [GO:0044375]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75192-1; Sequence=Displayed; Name=2; IsoId=O75192-2; Sequence=VSP_054753; 

location:
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:20826455, ECO:0000269|PubMed:9714566, ECO:0000269|PubMed:9792670}; Multi-pass membrane protein {ECO:0000269|PubMed:9714566, ECO:0000269|PubMed:9792670}.


uniprotID: Q8N0Z8
geneSymbol: PUSL1
length: 303
go: ENSG00000169972;
snps: rs12094447 rs34738574
name:
tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1)

sequence:

opentargets:
intracellular membrane-bounded organelle [GO:0043231]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthesis [GO:0031119]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N0Z8-1; Sequence=Displayed; Name=2; IsoId=Q8N0Z8-2; Sequence=VSP_036048; 


uniprotID: P27708
geneSymbol: CAD
reactome: R-HSA-500753;
pdb: 4BY3;4C6B;4C6C;4C6D;4C6E;4C6F;4C6I;4C6J;4C6K;4C6L;4C6M;4C6N;4C6O;4C6P;4C6Q;5G1N;5G1O;5G1P;
length: 2225
go: ENSG00000084774;
drug: DB00128;DB00130;DB03459;
snps: rs751610198 rs374122292 rs763410987
name:
CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)]

sequence:

opentargets:
cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; terminal bouton [GO:0043195]; aspartate binding [GO:0070335]; aspartate carbamoyltransferase activity [GO:0004070]; ATP binding [GO:0005524]; carbamoyl-phosphate synthase (ammonia) activity [GO:0004087]; carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [GO:0004088]; dihydroorotase activity [GO:0004151]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; protein kinase activity [GO:0004672]; zinc ion binding [GO:0008270]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; animal organ regeneration [GO:0031100]; arginine biosynthetic process [GO:0006526]; carbamoyl phosphate biosynthetic process [GO:0070409]; cellular response to drug [GO:0035690]; cellular response to epidermal growth factor stimulus [GO:0071364]; citrulline biosynthetic process [GO:0019240]; drug metabolic process [GO:0017144]; female pregnancy [GO:0007565]; glutamine metabolic process [GO:0006541]; heart development [GO:0007507]; lactation [GO:0007595]; liver development [GO:0001889]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; pyrimidine nucleoside biosynthetic process [GO:0046134]; response to amine [GO:0014075]; response to caffeine [GO:0031000]; response to cortisol [GO:0051414]; response to insulin [GO:0032868]; response to starvation [GO:0042594]; response to testosterone [GO:0033574]; urea cycle [GO:0000050]; UTP biosynthetic process [GO:0006228]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15890648}. Nucleus {ECO:0000269|PubMed:15890648}. Note=Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.


uniprotID: P0DMW2
geneSymbol: NLRP2B
sequence: MVSSAQLDFNLQALLGQLSQDDLCKFKSLIRTVSLGNELQKIPQT
length: 45
go: ENSG00000215174;
name:
NLR family pyrin domain-containing protein 2B (Pyrin domain-containing protein 2-like protein POP4) (Pyrin-only protein 4)

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; innate immune response [GO:0045087]; negative regulation of cell cycle [GO:0045786]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of toll-like receptor signaling pathway [GO:0034122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of apoptotic process [GO:0043065]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24871464}. Nucleus {ECO:0000269|PubMed:24871464}. Note=Targeted to the nucleus upon TNF-alpha treatment. {ECO:0000269|PubMed:24871464}.


uniprotID: W6CW81
geneSymbol: PYDC5
name: Pyrin domain-containing protein 5 (Pyrin domain-only protein 3)
length: 113
sequence:
MESKYKEILLLTSLDNITDEELDRFKCFLPDEFNIATGKLHTLNSTSSQLDLKRWHGVCSEEDRIFQKLNYMLVAKCLREEQETGICGSPSSARSVSQSRLGLSFHGISGNAC

opentargets:
cellular response to interferon-beta [GO:0035458]; cellular response to virus [GO:0098586]; negative regulation of protein complex assembly [GO:0031333]


uniprotID: Q9NRF8
geneSymbol: CTPS2
reactome: R-HSA-499943;
pdb: 2V4U;2VKT;3IHL;
name: CTP synthase 2 (EC 6.3.4.2) (CTP synthetase 2) (UTP--ammonia ligase 2)
length: 586
go: ENSG00000047230;
sequence:

opentargets:
cytosol [GO:0005829]; ATP binding [GO:0005524]; CTP synthase activity [GO:0003883]; 'de novo' CTP biosynthetic process [GO:0044210]; glutamine metabolic process [GO:0006541]; nucleobase-containing small molecule interconversion [GO:0015949]; pyrimidine nucleotide metabolic process [GO:0006220]


uniprotID: O95294
geneSymbol: RASAL1
reactome: R-HSA-5658442;R-HSA-6802949;
length: 804
go: ENSG00000111344;
snps: rs7960087 rs34598602 rs1284879
name:
RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein)

sequence:

opentargets:
cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; cellular response to calcium ion [GO:0071277]; MAPK cascade [GO:0000165]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of dendrite extension [GO:1903861]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O95294-1; Sequence=Displayed; Name=2; IsoId=O95294-2; Sequence=VSP_001627; Note=No experimental confirmation available.; Name=3; IsoId=O95294-3; Sequence=VSP_047005, VSP_047006; Note=Gene prediction based on EST data.; Name=4; IsoId=O95294-4; Sequence=VSP_047006; Note=No experimental confirmation available.; 


uniprotID: P57729
geneSymbol: RAB38
reactome: R-HSA-8873719;R-HSA-8876198;
name: Ras-related protein Rab-38 (Melanoma antigen NY-MEL-1)
length: 211
go: ENSG00000123892;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; membrane [GO:0016020]; Mitochondria-associated ER Membrane [GO:0044233]; mitochondrion [GO:0005739]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; AP-1 adaptor complex binding [GO:0035650]; AP-3 adaptor complex binding [GO:0035651]; BLOC-2 complex binding [GO:0036461]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; endosome to melanosome transport [GO:0035646]; intracellular protein transport [GO:0006886]; melanosome assembly [GO:1903232]; mitochondrion organization [GO:0007005]; phagosome acidification [GO:0090383]; platelet dense granule organization [GO:0060155]; positive regulation of phosphatidylcholine biosynthetic process [GO:2001247]; post-translational protein modification [GO:0043687]; protein localization to membrane [GO:0072657]; protein transport [GO:0015031]; Rab protein signal transduction [GO:0032482]; small GTPase mediated signal transduction [GO:0007264]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome membrane {ECO:0000269|PubMed:23084991}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). {ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:23084991}.


uniprotID: O60216
geneSymbol: RAD21
reactome: R-HSA-1221632;R-HSA-2467813;R-HSA-2468052;R-HSA-2470946;R-HSA-2500257;R-HSA-3108214;R-HSA-9018519;
pdb: 4PJU;4PJW;4PK7;
length: 631
go: ENSG00000164754;
snps: rs387907212 rs755168088 rs387907213
name:
Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog)

sequence:

opentargets:
chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic cohesin complex [GO:0030893]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; protein-containing complex binding [GO:0044877]; apoptotic process [GO:0006915]; cell division [GO:0051301]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; meiotic cell cycle [GO:0051321]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; positive regulation of sister chromatid cohesion [GO:0045876]; protein localization to chromatin [GO:0071168]; reciprocal meiotic recombination [GO:0007131]; regulation of transcription by RNA polymerase II [GO:0006357]; sister chromatid cohesion [GO:0007062]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10623634}. Chromosome {ECO:0000269|PubMed:11073952}. Chromosome, centromere {ECO:0000269|PubMed:11073952}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis. {ECO:0000269|PubMed:11073952}.


uniprotID: Q86SE5
geneSymbol: RALYL
length: 291
go: ENSG00000184672;
opentargets: nucleus [GO:0005634]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]
name:
RNA-binding Raly-like protein (hRALYL) (Heterogeneous nuclear ribonucleoprotein C-like 3) (hnRNP core protein C-like 3)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86SE5-1; Sequence=Displayed; Name=2; IsoId=Q86SE5-2; Sequence=VSP_027725, VSP_027726; Name=3; IsoId=Q86SE5-3; Sequence=VSP_054067; Note=No experimental confirmation available.; 


uniprotID: Q8TD07
geneSymbol: RAET1E
reactome: R-HSA-198933;
length: 263
go: ENSG00000164520;
snps: rs9383583 rs2151910 rs6925151 rs9383921 rs9371533 rs57292884 rs2342767
name:
Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4)

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; regulation of immune response [GO:0050776]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; T cell mediated cytotoxicity [GO:0001913]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=ULBP4 {ECO:0000303|PubMed:12732206}, RAET1E {ECO:0000303|PubMed:15240696}; IsoId=Q8TD07-1; Sequence=Displayed; Name=2; Synonyms=RL-4 {ECO:0000303|Ref.5}, ULBP4-II {ECO:0000303|PubMed:18544572}; IsoId=Q8TD07-2; Sequence=VSP_010441; Name=3; IsoId=Q8TD07-3; Sequence=VSP_010442, VSP_010443; Note=No experimental confirmation available.; Name=4; Synonyms=RAET1E2 {ECO:0000303|PubMed:17470428}; IsoId=Q8TD07-4; Sequence=VSP_045012; Name=5; Synonyms=ULBP4-III {ECO:0000303|PubMed:18544572}; IsoId=Q8TD07-5; Sequence=VSP_059263; Name=6; Synonyms=ULBP4-I {ECO:0000303|PubMed:18544572}; IsoId=Q8TD07-6; Sequence=VSP_059262; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15240696}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 4: Secreted.


uniprotID: P11234
geneSymbol: RALB
reactome: R-HSA-171007;
pdb: 2KE5;2KWI;
name: Ras-related protein Ral-B
length: 206
go: ENSG00000144118;
sequence:

opentargets:
extracellular exosome [GO:0070062]; intracellular [GO:0005622]; midbody [GO:0030496]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to starvation [GO:0009267]; negative regulation of protein binding [GO:0032091]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; Ras protein signal transduction [GO:0007265]; regulation of exocyst assembly [GO:0001928]; regulation of exocyst localization [GO:0060178]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P11234-1; Sequence=Displayed; Name=2; IsoId=P11234-2; Sequence=VSP_055843; Note=No experimental confirmation available.; Name=3; IsoId=P11234-3; Sequence=VSP_055844; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17875936}; Lipid-anchor {ECO:0000269|PubMed:17875936}; Cytoplasmic side {ECO:0000269|PubMed:17875936}. Midbody {ECO:0000269|PubMed:18756269}. Note=During late cytokinesis, enriched at the midbody. {ECO:0000269|PubMed:18756269}.


uniprotID: Q8NC74
geneSymbol: RBBP8NL
name: RBBP8 N-terminal-like protein
length: 664
go: ENSG00000130701;
opentargets: extracellular space [GO:0005615]
snps: rs3810553 rs10888228 rs6089366 rs2236200
sequence:


uniprotID: P62834
geneSymbol: RAP1A
pdb: 1C1Y;1GUA;3KUC;4KVG;
length: 184
go: ENSG00000116473;
reactome:
R-HSA-170968;R-HSA-170984;R-HSA-354192;R-HSA-354194;R-HSA-372708;R-HSA-381676;R-HSA-392517;R-HSA-5674135;R-HSA-6798695;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802955;R-HSA-8875555;

name:
Ras-related protein Rap-1A (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)

sequence:
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; guanyl-nucleotide exchange factor complex [GO:0032045]; late endosome [GO:0005770]; myelin sheath [GO:0043209]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein transporter activity [GO:0008565]; protein-containing complex binding [GO:0044877]; Rap guanyl-nucleotide exchange factor activity [GO:0017034]; cellular response to cAMP [GO:0071320]; cellular response to drug [GO:0035690]; cellular response to glucose stimulus [GO:0071333]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; liver regeneration [GO:0097421]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of synaptic vesicle exocytosis [GO:2000301]; nerve growth factor signaling pathway [GO:0038180]; neutrophil degranulation [GO:0043312]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of glucose import [GO:0046326]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein transport [GO:0015031]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of insulin secretion [GO:0050796]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; response to antineoplastic agent [GO:0097327]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.


uniprotID: P62826
geneSymbol: RAN
reactome: R-HSA-165054;R-HSA-1655829;R-HSA-168333;R-HSA-180746;R-HSA-203927;R-HSA-5578749;R-HSA-6784531;
length: 216
go: ENSG00000132341;
drug: DB04315;
pdb:
1I2M;1IBR;1K5D;1K5G;1QBK;1RRP;2MMC;2MMG;2N1B;3CH5;3EA5;3GJ0;3GJ3;3GJ4;3GJ5;3GJ6;3GJ7;3GJ8;3GJX;3NBY;3NBZ;3NC0;3NC1;3ZJY;4C0Q;4GMX;4GPT;4HAT;4HAU;4HAV;4HAW;4HAX;4HAY;4HAZ;4HB0;4HB2;4HB3;4HB4;4OL0;4WVF;5CIQ;5CIT;5CIW;5CJ2;5CLL;5CLQ;5DH9;5DHA;5DHF;5DI9;5DIF;5DIS;5DLQ;5FYQ;5JLJ;5UWH;5UWI;5UWJ;5UWO;5UWP;5UWQ;5UWR;5UWS;5UWT;5UWU;5UWW;6CIT;

name:
GTP-binding nuclear protein Ran (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)

sequence:

opentargets:
centriole [GO:0005814]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; host cell [GO:0043657]; male germ cell nucleus [GO:0001673]; manchette [GO:0002177]; melanosome [GO:0042470]; membrane [GO:0016020]; midbody [GO:0030496]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; RNA nuclear export complex [GO:0042565]; sperm flagellum [GO:0036126]; androgen receptor binding [GO:0050681]; cadherin binding [GO:0045296]; chromatin binding [GO:0003682]; dynein intermediate chain binding [GO:0045505]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; importin-alpha family protein binding [GO:0061676]; magnesium ion binding [GO:0000287]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; actin cytoskeleton organization [GO:0030036]; androgen receptor signaling pathway [GO:0030521]; cell division [GO:0051301]; cellular protein-containing complex localization [GO:0034629]; cellular response to mineralocorticoid stimulus [GO:0071389]; DNA metabolic process [GO:0006259]; GTP metabolic process [GO:0046039]; hippocampus development [GO:0021766]; intracellular transport of virus [GO:0075733]; miRNA metabolic process [GO:0010586]; mitotic cell cycle [GO:0000278]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle organization [GO:0007052]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription, DNA-templated [GO:0045893]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]; protein import into nucleus, translocation [GO:0000060]; protein localization to nucleolus [GO:1902570]; regulation of cholesterol biosynthetic process [GO:0045540]; ribosomal large subunit export from nucleus [GO:0000055]; ribosomal small subunit export from nucleus [GO:0000056]; snRNA import into nucleus [GO:0061015]; spermatid development [GO:0007286]; tRNA export from nucleus [GO:0006409]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:8421051, ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9351834, ECO:0000269|PubMed:9822603}. Nucleus envelope {ECO:0000269|PubMed:8896452, ECO:0000269|PubMed:9822603}. Cytoplasm, cytosol {ECO:0000269|PubMed:8276887}. Cytoplasm {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:9822603}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Predominantly nuclear during interphase (PubMed:8421051, PubMed:12194828, PubMed:10679025). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:8421051, PubMed:12194828). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:10679025, ECO:0000269|PubMed:12194828, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:8421051}.


uniprotID: Q9UDW1
geneSymbol: UQCR10
reactome: R-HSA-611105;
pdb: 5XTE;5XTH;5XTI;
sequence: MAAATLTSKLYSLLFRRTSTFALTIIVGVMFFERAFDQGADAIYDHINEGKLWKHIKHKYENK
length: 63
go: ENSG00000184076;
drug: DB08453;DB07778;DB07401;DB08330;DB08690;
snps: rs14115
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
name:
Cytochrome b-c1 complex subunit 9 (Complex III subunit 9) (Complex III subunit X) (Cytochrome c1 non-heme 7 kDa protein) (Ubiquinol-cytochrome c reductase complex 7.2 kDa protein)

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UDW1-1; Sequence=Displayed; Name=2; IsoId=Q9UDW1-2; Sequence=VSP_041429; 


uniprotID: Q6MZT1
geneSymbol: RGS7BP
name: Regulator of G-protein signaling 7-binding protein (R7 family-binding protein)
length: 257
go: ENSG00000186479;
snps: rs889248
sequence:

opentargets:
anchored component of postsynaptic density membrane [GO:0099031]; anchored component of presynaptic membrane [GO:0099026]; cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of postsynaptic membrane potential [GO:0060078]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BQP9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BQP9}. Cell membrane {ECO:0000250|UniProtKB:Q8BQP9}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BQP9}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250|UniProtKB:Q8BQP9}.


uniprotID: Q8IY67
geneSymbol: RAVER1
pdb: 3H2U;3H2V;3SMZ;3VF0;
name: Ribonucleoprotein PTB-binding 1 (Protein raver-1)
length: 606
go: ENSG00000161847;
opentargets: cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IY67-1; Sequence=Displayed; Name=2; IsoId=Q8IY67-2; Sequence=VSP_017035, VSP_017036; Name=3; IsoId=Q8IY67-3; Sequence=VSP_040968, VSP_040969; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Nuclear, in perinucleolar structures. Shuttles between nucleus and cytoplasm. Cytoplasm, at focal contacts and cell-cell contacts. Associated with myotubes during muscle differentiation (By similarity). {ECO:0000250}.


uniprotID: Q15283
geneSymbol: RASA2
reactome: R-HSA-5658442;R-HSA-6802949;
name: Ras GTPase-activating protein 2 (GTPase-activating protein 1m) (GAP1m)
length: 850
go: ENSG00000155903;
location: SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region.
sequence:

opentargets:
cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; MAPK cascade [GO:0000165]; negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15283-1; Sequence=Displayed; Name=2; IsoId=Q15283-2; Sequence=VSP_046545; 


uniprotID: Q08257
geneSymbol: CRYZ
pdb: 1YB5;
name: Quinone oxidoreductase (EC 1.6.5.5) (NADPH:quinone reductase) (Zeta-crystallin)
length: 329
go: ENSG00000116791;
drug: DB03461;DB00266;
snps: rs11551729 rs3819946 rs17095822
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20103721}.
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; mRNA 3'-UTR binding [GO:0003730]; NADPH binding [GO:0070402]; NADPH:quinone reductase activity [GO:0003960]; zinc ion binding [GO:0008270]; protein homotetramerization [GO:0051289]; visual perception [GO:0007601]; xenobiotic catabolic process [GO:0042178]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q08257-1; Sequence=Displayed; Name=2; IsoId=Q08257-2; Sequence=VSP_042927, VSP_042928; Note=No experimental confirmation available.; Name=3; IsoId=Q08257-3; Sequence=VSP_046425; Note=No experimental confirmation available.; 


uniprotID: Q04671
geneSymbol: OCA2
reactome: R-HSA-5662702;
name: P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)
length: 838
go: ENSG00000104044;
sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; melanosome membrane [GO:0033162]; L-tyrosine transmembrane transporter activity [GO:0005302]; transporter activity [GO:0005215]; cell proliferation [GO:0008283]; eye pigment biosynthetic process [GO:0006726]; melanin biosynthetic process [GO:0042438]; melanocyte differentiation [GO:0030318]; spermatid development [GO:0007286]

snps:
rs554862186 rs61738394 rs772243109 rs562649990 rs183487020 rs190612616 rs2305253 rs1050968 rs33929465 rs797044784 rs769408559 rs1800401 rs121918168 rs34010619 rs533478642 rs61745150 rs34731820 rs137956605 rs150335311 rs121918171 rs757286784 rs144812594 rs1800407 rs143218168 rs1800408 rs121918166 rs140566426 rs74653330 rs121918170 rs41446944 rs35110389 rs1800413 rs1800414 rs763016773 rs1372200062 rs886043514 rs121918169 rs751822606 rs772754008 rs141545475 rs1800417 rs780296175 rs121918167 rs200457227 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q04671-1; Sequence=Displayed; Name=2; IsoId=Q04671-2; Sequence=VSP_012284; Name=3; IsoId=Q04671-3; Sequence=VSP_012285, VSP_012286; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:7601462}; Multi-pass membrane protein {ECO:0000269|PubMed:7601462}.


uniprotID: O00391
geneSymbol: QSOX1
reactome: R-HSA-114608;R-HSA-381426;R-HSA-6798695;R-HSA-8957275;
pdb: 3LLI;3LLK;3Q6O;4IJ3;
name: Sulfhydryl oxidase 1 (hQSOX) (EC 1.8.3.2) (Quiescin Q6)
length: 747
go: ENSG00000116260;
snps: rs3894211 rs17855475 rs4360492 rs2278943 rs12371 rs3738115 rs16855466
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; integral component of Golgi membrane [GO:0030173]; intercellular bridge [GO:0045171]; intracellular membrane-bounded organelle [GO:0043231]; platelet alpha granule lumen [GO:0031093]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; flavin-linked sulfhydryl oxidase activity [GO:0016971]; protein disulfide isomerase activity [GO:0003756]; cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; negative regulation of macroautophagy [GO:0016242]; neutrophil degranulation [GO:0043312]; platelet degranulation [GO:0002576]; post-translational protein modification [GO:0043687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=a, QSOX-L; IsoId=O00391-1; Sequence=Displayed; Name=2; Synonyms=b, QSOX-S; IsoId=O00391-2; Sequence=VSP_020489, VSP_020490; 

location:
SUBCELLULAR LOCATION: Isoform 1: Golgi apparatus membrane; Single-pass membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted, extracellular space. Note=Found in the extracellular medium of quiescent cells but is not found in proliferating cells.


uniprotID: P11233
geneSymbol: RALA
reactome: R-HSA-1445148;R-HSA-171007;R-HSA-8950505;
pdb: 1UAD;1ZC3;1ZC4;2A78;2A9K;2BOV;
name: Ras-related protein Ral-A
length: 206
go: ENSG00000006451;
drug: DB04315;
sequence:

opentargets:
cell surface [GO:0009986]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; ATPase binding [GO:0051117]; Edg-2 lysophosphatidic acid receptor binding [GO:0031755]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin binding [GO:0017022]; ubiquitin protein ligase binding [GO:0031625]; actin cytoskeleton reorganization [GO:0031532]; cell cycle [GO:0007049]; cell division [GO:0051301]; chemotaxis [GO:0006935]; exocytosis [GO:0006887]; interleukin-12-mediated signaling pathway [GO:0035722]; membrane organization [GO:0061024]; membrane raft localization [GO:0051665]; neural tube closure [GO:0001843]; positive regulation of filopodium assembly [GO:0051491]; Ras protein signal transduction [GO:0007265]; regulation of exocytosis [GO:0017157]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17875936, ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925}; Lipid-anchor {ECO:0000269|PubMed:17875936}; Cytoplasmic side. Cleavage furrow {ECO:0000269|PubMed:18756269}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Predominantly at the cell surface in the absence of LPA. In the presence of LPA, colocalizes with LPAR1 and LPAR2 in endocytic vesicles (PubMed:19306925). May colocalize with CNTRL/centriolin at the midbody ring (PubMed:16213214). However, localization at the midbody at late cytokinesis was not confirmed (PubMed:18756269). {ECO:0000269|PubMed:16213214, ECO:0000269|PubMed:18756269, ECO:0000269|PubMed:19306925}.


uniprotID: P51153
geneSymbol: RAB13
reactome: R-HSA-1445148;R-HSA-8873719;R-HSA-8876198;
name: Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)
length: 203
go: ENSG00000143545;
sequence:

opentargets:
bicellular tight junction [GO:0005923]; cell junction [GO:0030054]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; bicellular tight junction assembly [GO:0070830]; cellular response to insulin stimulus [GO:0032869]; cortical actin cytoskeleton organization [GO:0030866]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; endothelial cell chemotaxis [GO:0035767]; establishment of Sertoli cell barrier [GO:0097368]; intracellular protein transport [GO:0006886]; neuron projection development [GO:0031175]; post-translational protein modification [GO:0043687]; protein kinase A signaling [GO:0010737]; protein localization to plasma membrane [GO:0072659]; Rab protein signal transduction [GO:0032482]; trans-Golgi network to recycling endosome transport [GO:0044795]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15528189}; Lipid-anchor {ECO:0000305|PubMed:8375503}; Cytoplasmic side {ECO:0000305|PubMed:8375503}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:15528189, ECO:0000269|PubMed:8294494}; Lipid-anchor {ECO:0000305|PubMed:8375503}; Cytoplasmic side {ECO:0000305|PubMed:8375503}. Cell junction, tight junction {ECO:0000269|PubMed:12058051, ECO:0000269|PubMed:8294494}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18779367}. Recycling endosome membrane {ECO:0000269|PubMed:18779367}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9DD03}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250|UniProtKB:Q9DD03, ECO:0000269|PubMed:8294494}.


uniprotID: P61006
geneSymbol: RAB8A
reactome: R-HSA-1445148;R-HSA-2565942;R-HSA-5620912;R-HSA-5620916;R-HSA-8854214;R-HSA-8873719;R-HSA-8876198;
pdb: 3QBT;3TNF;4LHV;4LHW;4LHX;4LHY;4LHZ;4LI0;5SZI;
name: Ras-related protein Rab-8A (Oncogene c-mel)
length: 207
go: ENSG00000167461;
sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cilium [GO:0005929]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; midbody [GO:0030496]; neuronal cell body [GO:0043025]; non-motile cilium [GO:0097730]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; recycling endosome membrane [GO:0055038]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; trans-Golgi network transport vesicle [GO:0030140]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein kinase binding [GO:0019901]; Rab GTPase binding [GO:0017137]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; cilium assembly [GO:0060271]; Golgi vesicle fusion to target membrane [GO:0048210]; intracellular protein transport [GO:0006886]; neurotransmitter receptor transport to postsynaptic membrane [GO:0098969]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; post-translational protein modification [GO:0043687]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of autophagy [GO:0010506]; regulation of exocytosis [GO:0017157]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of protein transport [GO:0051223]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport in synapse [GO:0099003]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61006-1; Sequence=Displayed; Name=2; IsoId=P61006-2; Sequence=VSP_056399; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:12221131}; Lipid-anchor {ECO:0000305|PubMed:12221131}; Cytoplasmic side {ECO:0000305|PubMed:12221131}. Golgi apparatus {ECO:0000269|PubMed:15837803}. Recycling endosome membrane {ECO:0000269|PubMed:19864458}. Cell projection, cilium {ECO:0000269|PubMed:21844891}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q92930}; Lipid-anchor {ECO:0000250|UniProtKB:Q92930}; Cytoplasmic side {ECO:0000250|UniProtKB:Q92930}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P55258}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P55258}. Midbody {ECO:0000269|PubMed:22159412}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane (PubMed:15837803). In the GDP-bound form, present in the perinuclear region (PubMed:12221131). Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form (PubMed:12221131). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Localizes to tubular recycling endosome (PubMed:19864458). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:12221131, ECO:0000269|PubMed:15837803, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21255211}.


uniprotID: Q15032
geneSymbol: R3HDM1
name: R3H domain-containing protein 1
length: 1099
go: ENSG00000048991;
opentargets: RNA binding [GO:0003723]
snps: rs961360 rs2305165
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q15032-1; Sequence=Displayed; Name=2; IsoId=Q15032-2; Sequence=VSP_017344, VSP_017345, VSP_054310; Name=3; IsoId=Q15032-3; Sequence=VSP_054310; Name=4; IsoId=Q15032-4; Sequence=VSP_054308, VSP_054309, VSP_054310; Note=No experimental confirmation available.; 


uniprotID: Q6ZMN7
geneSymbol: PDZRN4
name: PDZ domain-containing RING finger protein 4 (Ligand of Numb protein X 4) (SEMACAP3-like protein)
length: 1036
go: ENSG00000165966;
snps: rs285584
sequence:

opentargets:
metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZMN7-1; Sequence=Displayed; Name=2; Synonyms=PDZRN4S; IsoId=Q6ZMN7-2; Sequence=VSP_012611, VSP_012612; Name=4; IsoId=Q6ZMN7-4; Sequence=VSP_012614, VSP_012615; Note=No experimental confirmation available.; 


uniprotID: P63000
geneSymbol: RAC1
length: 192
go: ENSG00000136238;
drug: DB00514;DB04315;
snps: rs5830 rs5832 rs5837 rs5831 rs5826 rs5825 rs5838 rs5828 rs5835 rs11540455 rs16063 rs5836
reactome:
R-HSA-114604;R-HSA-1433557;R-HSA-1445148;R-HSA-164944;R-HSA-193648;R-HSA-194840;R-HSA-2029482;R-HSA-2424491;R-HSA-2871796;R-HSA-376172;R-HSA-389359;R-HSA-3928662;R-HSA-3928664;R-HSA-3928665;R-HSA-399954;R-HSA-399955;R-HSA-4086400;R-HSA-416482;R-HSA-416550;R-HSA-418885;R-HSA-428540;R-HSA-428543;R-HSA-4420097;R-HSA-445144;R-HSA-5218920;R-HSA-5625740;R-HSA-5625900;R-HSA-5625970;R-HSA-5626467;R-HSA-5627123;R-HSA-5663213;R-HSA-5663220;R-HSA-5668599;R-HSA-5687128;R-HSA-6798695;R-HSA-8849471;R-HSA-8875555;R-HSA-9032759;R-HSA-9032845;R-HSA-983231;

pdb:
1E96;1FOE;1G4U;1HE1;1HH4;1I4D;1I4L;1I4T;1MH1;1RYF;1RYH;2FJU;2H7V;2NZ8;2P2L;2RMK;2VRW;2WKP;2WKQ;2WKR;2YIN;3B13;3BJI;3RYT;3SBD;3SBE;3SU8;3SUA;3TH5;4GZL;4GZM;4YON;5FI0;5HZH;5N6O;5O33;6BC1;

name:
Ras-related C3 botulinum toxin substrate 1 (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)

sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; recycling endosome membrane [GO:0055038]; ruffle membrane [GO:0032587]; secretory granule membrane [GO:0030667]; trans-Golgi network [GO:0005802]; ATPase binding [GO:0051117]; enzyme binding [GO:0019899]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; Rab GTPase binding [GO:0017137]; Rho GDP-dissociation inhibitor binding [GO:0051022]; thioesterase binding [GO:0031996]; actin cytoskeleton organization [GO:0030036]; actin filament polymerization [GO:0030041]; anatomical structure morphogenesis [GO:0009653]; blood coagulation [GO:0007596]; bone resorption [GO:0045453]; cell adhesion [GO:0007155]; cell motility [GO:0048870]; cell projection assembly [GO:0030031]; cell proliferation [GO:0008283]; cell-matrix adhesion [GO:0007160]; cellular response to mechanical stimulus [GO:0071260]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; inflammatory response [GO:0006954]; intracellular signal transduction [GO:0035556]; lamellipodium assembly [GO:0030032]; localization within membrane [GO:0051668]; mast cell chemotaxis [GO:0002551]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of receptor-mediated endocytosis [GO:0048261]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; neutrophil degranulation [GO:0043312]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of DNA replication [GO:0045740]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; Rac protein signal transduction [GO:0016601]; regulation of cell migration [GO:0030334]; regulation of cell size [GO:0008361]; regulation of defense response to virus by virus [GO:0050690]; regulation of hydrogen peroxide metabolic process [GO:0010310]; regulation of lamellipodium assembly [GO:0010591]; regulation of nitric oxide biosynthetic process [GO:0045428]; regulation of respiratory burst [GO:0060263]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of stress fiber assembly [GO:0051492]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266]; ruffle assembly [GO:0097178]; ruffle organization [GO:0031529]; semaphorin-plexin signaling pathway [GO:0071526]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell costimulation [GO:0031295]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=A; Synonyms=Rac1A; IsoId=P63000-1, P15154-1; Sequence=Displayed; Name=B; Synonyms=Rac1B, Rac1ins; IsoId=P63000-2, P15154-2; Sequence=VSP_005710; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1643658}; Lipid-anchor {ECO:0000269|PubMed:1903399}; Cytoplasmic side {ECO:0000269|PubMed:1643658, ECO:0000269|PubMed:19948726}. Melanosome {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:19948726, ECO:0000269|PubMed:21693584}. Cytoplasm {ECO:0000269|PubMed:19948726}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P63001}. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (PubMed:1903399). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts. Localizes to the lamellipodium in a SH3RF1-dependent manner (By similarity). {ECO:0000250|UniProtKB:P63001, ECO:0000250|UniProtKB:Q6RUV5, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:1903399}.


uniprotID: Q969Q5
geneSymbol: RAB24
reactome: R-HSA-6798695;R-HSA-8873719;
name: Ras-related protein Rab-24
length: 203
go: ENSG00000169228;
sequence:

opentargets:
autophagosome [GO:0005776]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; Rab protein signal transduction [GO:0032482]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10660536}. Membrane {ECO:0000269|PubMed:10660536}; Lipid-anchor {ECO:0000305}. Note=Only about 20-25% is recovered in the particulate fraction. {ECO:0000269|PubMed:10660536}.


uniprotID: P10082
geneSymbol: PYY
reactome: R-HSA-375276;R-HSA-418594;
pdb: 2DEZ;2DF0;2L60;2NA5;
name: Peptide YY (PYY) (PYY-I) (Peptide tyrosine tyrosine) [Cleaved into: Peptide YY(3-36) (PYY-II)]
sequence: MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW
length: 97
go: ENSG00000131096;
snps: rs229969 rs1058046 rs465407
location: SUBCELLULAR LOCATION: Secreted.
opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; cell proliferation [GO:0008283]; feeding behavior [GO:0007631]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Long; IsoId=P10082-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P10082-2; Sequence=VSP_005081; 


uniprotID: P10826
geneSymbol: RARB
reactome: R-HSA-383280;R-HSA-5362517;R-HSA-5617472;
pdb: 1HRA;1XAP;4DM6;4DM8;4JYG;4JYH;4JYI;5UAN;
length: 455
go: ENSG00000077092;
drug: DB00459;DB00210;DB00523;DB00926;DB05785;DB04942;DB00799;DB02877;
name:
Retinoic acid receptor beta (RAR-beta) (HBV-activated protein) (Nuclear receptor subfamily 1 group B member 2) (RAR-epsilon)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; drug binding [GO:0008144]; nuclear receptor transcription coactivator activity [GO:0030374]; protein-containing complex binding [GO:0044877]; retinoic acid receptor activity [GO:0003708]; retinoid X receptor binding [GO:0046965]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; signaling receptor activity [GO:0038023]; steroid hormone receptor activity [GO:0003707]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270]; bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; cellular response to retinoic acid [GO:0071300]; embryonic digestive tract development [GO:0048566]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; gland development [GO:0048732]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hormone-mediated signaling pathway [GO:0009755]; liver development [GO:0001889]; multicellular organism development [GO:0007275]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myelination [GO:0031641]; response to lipid [GO:0033993]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]; signal transduction [GO:0007165]; striatum development [GO:0021756]; transcription initiation from RNA polymerase II promoter [GO:0006367]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=Beta-1; IsoId=P10826-1; Sequence=Displayed; Name=Beta-2; IsoId=P10826-2; Sequence=VSP_003634; Name=Beta-3; IsoId=P10826-4; Sequence=Not described; Name=Beta-4; IsoId=P10826-3; Sequence=VSP_003635; 

location:
SUBCELLULAR LOCATION: Isoform Beta-1: Nucleus.; SUBCELLULAR LOCATION: Isoform Beta-2: Nucleus.; SUBCELLULAR LOCATION: Isoform Beta-4: Cytoplasm.


uniprotID: P61019
geneSymbol: RAB2A
reactome: R-HSA-162658;R-HSA-8873719;
pdb: 1Z0A;
name: Ras-related protein Rab-2A
length: 212
go: ENSG00000104388;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; nucleus [GO:0005634]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; post-translational protein modification [GO:0043687]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61019-1; Sequence=Displayed; Name=2; IsoId=P61019-2; Sequence=VSP_042917; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Endoplasmic reticulum membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.


uniprotID: Q9HCJ3
geneSymbol: RAVER2
pdb: 1WG1;
name: Ribonucleoprotein PTB-binding 2 (Protein raver-2)
length: 691
go: ENSG00000162437;
opentargets: cytoplasm [GO:0005737]; nucleus [GO:0005634]; RNA binding [GO:0003723]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HCJ3-1; Sequence=Displayed; Name=2; IsoId=Q9HCJ3-2; Sequence=VSP_013676; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=May shuttle between the nucleus and the cytoplasm. {ECO:0000250}.


uniprotID: Q15771
geneSymbol: RAB30
reactome: R-HSA-6811438;R-HSA-8873719;
pdb: 2EW1;
name: Ras-related protein Rab-30
length: 203
go: ENSG00000137502;
sequence:

opentargets:
cis-Golgi network [GO:0005801]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna [GO:0031985]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network [GO:0005802]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15771-1; Sequence=Displayed; Name=2; IsoId=Q15771-2; Sequence=VSP_055833, VSP_055834; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:22188167}. Cytoplasm {ECO:0000269|PubMed:22188167}. Golgi apparatus {ECO:0000269|PubMed:22188167}.


uniprotID: Q6ZS82
geneSymbol: RGS9BP
reactome: R-HSA-2514859;
name: Regulator of G-protein signaling 9-binding protein (RGS9-anchoring protein)
length: 235
go: ENSG00000186326;
snps: rs259290
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; photoreceptor outer segment [GO:0001750]; detection of light stimulus involved in visual perception [GO:0050908]; negative regulation of signal transduction [GO:0009968]


uniprotID: P63244
geneSymbol: RACK1
reactome: R-HSA-5357905;R-HSA-5357956;R-HSA-5626978;
pdb: 4AOW;4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G51;6G53;6G5H;6G5I;
length: 317
go: ENSG00000204628;
name:
Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; IRE1-RACK1-PP2A complex [GO:1990630]; midbody [GO:0030496]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; phagocytic cup [GO:0001891]; small ribosomal subunit [GO:0015935]; cadherin binding [GO:0045296]; cyclin binding [GO:0030332]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; enzyme binding [GO:0019899]; ion channel inhibitor activity [GO:0008200]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase inhibitor activity [GO:0030292]; protein-containing complex scaffold activity [GO:0032947]; receptor tyrosine kinase binding [GO:0030971]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; SH2 domain binding [GO:0042169]; signaling adaptor activity [GO:0035591]; signaling receptor binding [GO:0005102]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cell cycle [GO:0007049]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth factor stimulus [GO:0071363]; gastrulation [GO:0007369]; negative regulation of cell growth [GO:0030308]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of gene expression [GO:0010629]; negative regulation of hydrogen peroxide-induced neuron death [GO:1903208]; negative regulation of peptidyl-serine phosphorylation [GO:0033137]; negative regulation of phagocytosis [GO:0050765]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of translation [GO:0017148]; negative regulation of Wnt signaling pathway [GO:0030178]; pigmentation [GO:0043473]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell migration [GO:0030335]; positive regulation of ceramide biosynthetic process [GO:2000304]; positive regulation of cyclic-nucleotide phosphodiesterase activity [GO:0051343]; positive regulation of gastrulation [GO:2000543]; positive regulation of Golgi to plasma membrane protein transport [GO:0042998]; positive regulation of GTPase activity [GO:0043547]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein homooligomerization [GO:0032464]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell division [GO:0051302]; regulation of establishment of cell polarity [GO:2000114]; regulation of protein localization [GO:0032880]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; rescue of stalled ribosome [GO:0072344]; rhythmic process [GO:0048511]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11312657, ECO:0000269|PubMed:17956333}; Peripheral membrane protein. Cytoplasm {ECO:0000269|PubMed:10849009, ECO:0000269|PubMed:11279199, ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:19785988, ECO:0000269|PubMed:20499158, ECO:0000269|PubMed:20573744}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11279199, ECO:0000269|PubMed:12958311}. Nucleus {ECO:0000269|PubMed:10849009}. Perikaryon {ECO:0000250|UniProtKB:P68040}. Cell projection, dendrite {ECO:0000250|UniProtKB:P68040}. Cell projection, phagocytic cup {ECO:0000269|PubMed:21347310}. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). {ECO:0000250|UniProtKB:P68040, ECO:0000269|PubMed:11279199, ECO:0000269|PubMed:11884618, ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:21347310}.


uniprotID: Q09MP3
geneSymbol: RAD51AP2
name: RAD51-associated protein 2
length: 1159
go: ENSG00000214842;
opentargets: protein-containing complex [GO:0032991]
snps: rs17380212 rs17314548 rs834514
sequence:


uniprotID: Q9UL26
geneSymbol: RAB22A
reactome: R-HSA-8873719;
name: Ras-related protein Rab-22A (Rab-22)
length: 194
go: ENSG00000124209;
sequence:
MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANLPSGGKGFKLRRQPSEPKRSCC

opentargets:
actin cytoskeleton [GO:0015629]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]; regulation of vesicle size [GO:0097494]

location:
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Early endosome {ECO:0000269|PubMed:16537905}. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle {ECO:0000269|PubMed:21419809}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.


uniprotID: Q9UKM9
geneSymbol: RALY
pdb: 1WF1;
length: 306
go: ENSG00000125970;
snps: rs35191085 rs3180568 rs2281209
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64012}.
name:
RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]; RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]; cholesterol homeostasis [GO:0042632]; mRNA splicing, via spliceosome [GO:0000398]; regulation of nucleic acid-templated transcription [GO:1903506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=Q9UKM9-1; Sequence=Displayed; Name=1; IsoId=Q9UKM9-2; Sequence=VSP_005804; 


uniprotID: P07919
geneSymbol: UQCRH
reactome: R-HSA-611105;
pdb: 5XTE;5XTH;5XTI;
sequence: MGLEDEQKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELCDERVSSRSHTEEDCTEELFDFLHARDHCVAHKLFNNLK
length: 91
go: ENSG00000173660;
drug: DB08453;DB07778;DB07401;DB08330;DB08690;
snps: rs34813470
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00127}.
name:
Cytochrome b-c1 complex subunit 6, mitochondrial (Complex III subunit 6) (Complex III subunit VIII) (Cytochrome c1 non-heme 11 kDa protein) (Mitochondrial hinge protein) (Ubiquinol-cytochrome c reductase complex 11 kDa protein)

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrion [GO:0005739]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; oxidation-reduction process [GO:0055114]; oxidative phosphorylation [GO:0006119]


uniprotID: P61020
geneSymbol: RAB5B
reactome: R-HSA-6798695;R-HSA-8854214;R-HSA-8856828;R-HSA-8873719;R-HSA-8876198;
pdb: 2HEI;
name: Ras-related protein Rab-5B
length: 215
go: ENSG00000111540;
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; antigen processing and presentation [GO:0019882]; endosome organization [GO:0007032]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; plasma membrane to endosome transport [GO:0048227]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61020-1; Sequence=Displayed; Name=2; IsoId=P61020-2; Sequence=VSP_045301; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Early endosome membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.


uniprotID: Q13636
geneSymbol: RAB31
reactome: R-HSA-6798695;R-HSA-8873719;R-HSA-8876198;
pdb: 2FG5;
name: Ras-related protein Rab-31 (Ras-related protein Rab-22B)
length: 194
sequence:
MAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFYTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPHENGNNGTIKVEKPTMQASRRCC

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; trans-Golgi network membrane [GO:0032588]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to insulin stimulus [GO:0032869]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; phagosome maturation [GO:0090382]; Rab protein signal transduction [GO:0032482]; receptor internalization [GO:0031623]; regulated exocytosis [GO:0045055]

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17678623, ECO:0000269|PubMed:19725050, ECO:0000269|PubMed:21586568}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:21586568}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Rapidly recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.


uniprotID: Q7Z444
geneSymbol: ERAS
name: GTPase ERas (E-Ras) (Embryonic stem cell-expressed Ras)
length: 233
go: ENSG00000187682;
sequence:

opentargets:
plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q9BUV8
geneSymbol: RAB5IF
name: Uncharacterized protein RAB5IF (Rab5-interacting protein) (RIP5)
length: 137
go: ENSG00000101084;
sequence:
MSGGRRKEEPPQPQLANGALKVSVWSKVLRSDAAWEDKDEFLDVIYWFRQIIAVVLGVIWGVLPLRGFLGIAGFCLINAGVLYLYFSNYLQIDEEEYGGTWELTKEGFMTSFALFMVCVADSFTTGHLDHLLHCHPL

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9BUV8-1; Sequence=Displayed; Name=2; IsoId=Q9BUV8-2; Sequence=VSP_003796; Name=3; IsoId=Q9BUV8-3; Sequence=VSP_003797; Name=4; IsoId=Q9BUV8-4; Sequence=VSP_003795; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q9BUV8-5; Sequence=VSP_047233; Note=Gene prediction based on EST data.; 


uniprotID: P24386
geneSymbol: CHM
reactome: R-HSA-6803205;R-HSA-8873719;R-HSA-8876198;
length: 653
go: ENSG00000188419;
snps: rs397514603
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7957092}.
name:
Rab proteins geranylgeranyltransferase component A 1 (Choroideremia protein) (Rab escort protein 1) (REP-1) (TCD protein)

sequence:

opentargets:
cytosol [GO:0005829]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab geranylgeranyltransferase activity [GO:0004663]; Rab GTPase binding [GO:0017137]; post-translational protein modification [GO:0043687]; protein geranylgeranylation [GO:0018344]; protein targeting to membrane [GO:0006612]; regulation of apoptotic process [GO:0042981]; small GTPase mediated signal transduction [GO:0007264]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P24386-1; Sequence=Displayed; Name=2; IsoId=P24386-2; Sequence=VSP_042817, VSP_042818; Note=No experimental confirmation available.; 


uniprotID: P55895
geneSymbol: RAG2
reactome: R-HSA-1266695;R-HSA-5687128;
name: V(D)J recombination-activating protein 2 (RAG-2)
length: 527
go: ENSG00000175097;
snps: rs121917895 rs121918574 rs121917894 rs121917896 rs16929093 rs121918575 rs121918573
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; methylated histone binding [GO:0035064]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; B cell differentiation [GO:0030183]; B cell homeostatic proliferation [GO:0002358]; B cell lineage commitment [GO:0002326]; chromatin organization [GO:0006325]; defense response to bacterium [GO:0042742]; positive regulation of organ growth [GO:0046622]; pre-B cell allelic exclusion [GO:0002331]; T cell differentiation in thymus [GO:0033077]; T cell lineage commitment [GO:0002360]; V(D)J recombination [GO:0033151]


uniprotID: Q15276
geneSymbol: RABEP1
reactome: R-HSA-8854214;
pdb: 1P4U;1TU3;1X79;4N3Y;4N3Z;4Q9U;
length: 862
go: ENSG00000029725;
snps: rs3026099
location: SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
name:
Rab GTPase-binding effector protein 1 (Rabaptin-4) (Rabaptin-5) (Rabaptin-5alpha) (Renal carcinoma antigen NY-REN-17)

sequence:

opentargets:
early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; apoptotic process [GO:0006915]; endocytosis [GO:0006897]; membrane fusion [GO:0061025]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Rabaptin-5; IsoId=Q15276-1; Sequence=Displayed; Name=2; Synonyms=Rabaptin-4; IsoId=Q15276-2; Sequence=VSP_010451; 


uniprotID: P78406
geneSymbol: RAE1
pdb: 3MMY;4OWR;
name: mRNA export factor (Rae1 protein homolog) (mRNA-associated protein mrnp 41)
length: 368
go: ENSG00000101146;
reactome:
R-HSA-1169408;R-HSA-159227;R-HSA-159230;R-HSA-159231;R-HSA-159236;R-HSA-165054;R-HSA-168271;R-HSA-168276;R-HSA-168325;R-HSA-168333;R-HSA-170822;R-HSA-180746;R-HSA-180910;R-HSA-191859;R-HSA-3108214;R-HSA-3232142;R-HSA-3301854;R-HSA-3371453;R-HSA-4085377;R-HSA-4551638;R-HSA-4570464;R-HSA-4615885;R-HSA-5578749;R-HSA-6784531;

sequence:

opentargets:
cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; mitotic spindle pole [GO:0097431]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; ubiquitin binding [GO:0043130]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to organic cyclic compound [GO:0071407]; mRNA export from nucleus [GO:0006406]; regulation of mitotic spindle organization [GO:0060236]; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [GO:0000972]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9256445}. Nucleus {ECO:0000269|PubMed:9256445}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:17172455}. Note=Recruited from interphase nuclei to spindle MTs during mitosis. {ECO:0000269|PubMed:17172455}.


uniprotID: Q8IZ41
geneSymbol: RASEF
pdb: 2P5S;2PMY;
name: Ras and EF-hand domain-containing protein (Ras-related protein Rab-45)
length: 740
go: ENSG00000165105;
snps: rs4146960
location: SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17448446}.
sequence:

opentargets:
cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; protein homooligomerization [GO:0051260]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IZ41-1; Sequence=Displayed; Name=2; IsoId=Q8IZ41-2; Sequence=VSP_027766, VSP_027767; Note=No experimental confirmation available.; 


uniprotID: P51159
geneSymbol: RAB27A
reactome: R-HSA-264876;R-HSA-6798695;R-HSA-8873719;R-HSA-8876198;
name: Ras-related protein Rab-27A (Rab-27) (GTP-binding protein Ram)
length: 221
go: ENSG00000069974;
snps: rs1050930 rs28938176 rs4340274 rs719705 rs104894498 rs104894499
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; dendrite [GO:0030425]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; late endosome [GO:0005770]; lysosome [GO:0005764]; melanosome [GO:0042470]; melanosome membrane [GO:0033162]; multivesicular body membrane [GO:0032585]; photoreceptor outer segment [GO:0001750]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; specific granule lumen [GO:0035580]; synapse [GO:0045202]; Weibel-Palade body [GO:0033093]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]; antigen processing and presentation [GO:0019882]; blood coagulation [GO:0007596]; complement-dependent cytotoxicity [GO:0097278]; cytotoxic T cell degranulation [GO:0043316]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; intracellular protein transport [GO:0006886]; melanocyte differentiation [GO:0030318]; melanosome localization [GO:0032400]; melanosome transport [GO:0032402]; multivesicular body organization [GO:0036257]; multivesicular body sorting pathway [GO:0071985]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; positive regulation of constitutive secretory pathway [GO:1903435]; positive regulation of exocytosis [GO:0045921]; positive regulation of gene expression [GO:0010628]; positive regulation of phagocytosis [GO:0050766]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of regulated secretory pathway [GO:1903307]; protein targeting [GO:0006605]; Rab protein signal transduction [GO:0032482]; synaptic vesicle transport [GO:0048489]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=P51159-1; Sequence=Displayed; Name=Short; IsoId=P51159-2; Sequence=VSP_005529; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Late endosome {ECO:0000269|PubMed:15548590}. Lysosome {ECO:0000269|PubMed:15548590}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). Localizes to endosomal exocytic vesicles (PubMed:17237785). {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:17237785}.


uniprotID: Q9BZE2
geneSymbol: PUS3
reactome: R-HSA-6782315;
length: 481
go: ENSG00000110060;
snps: rs622756 rs549990 rs3088241
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
tRNA pseudouridine(38/39) synthase (EC 5.4.99.45) (tRNA pseudouridine synthase 3) (tRNA pseudouridylate synthase 3) (tRNA-uridine isomerase 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; pseudouridine synthase activity [GO:0009982]; RNA binding [GO:0003723]; tRNA pseudouridine synthase activity [GO:0106029]; mRNA pseudouridine synthesis [GO:1990481]; tRNA modification [GO:0006400]; tRNA pseudouridine synthesis [GO:0031119]


uniprotID: Q15109
geneSymbol: AGER
reactome: R-HSA-445989;R-HSA-879415;R-HSA-933542;
length: 404
go: ENSG00000204305;
snps: rs2070600
pdb:
1PWI;2BJP;2E5E;2ENS;2L7U;2LE9;2LMB;2M1K;2MJW;2MOV;3CJJ;3O3U;4LP4;4LP5;4OF5;4OFV;4OI7;4OI8;4P2Y;4XYN;4YBH;5D7F;

name:
Advanced glycosylation end product-specific receptor (Receptor for advanced glycosylation end products)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; advanced glycation end-product receptor activity [GO:0050785]; amyloid-beta binding [GO:0001540]; identical protein binding [GO:0042802]; S100 protein binding [GO:0044548]; scavenger receptor activity [GO:0005044]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; amyloid-beta clearance [GO:0097242]; astrocyte development [GO:0014002]; cell surface receptor signaling pathway [GO:0007166]; cellular response to amyloid-beta [GO:1904646]; glucose mediated signaling pathway [GO:0010255]; induction of positive chemotaxis [GO:0050930]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; learning or memory [GO:0007611]; modulation of age-related behavioral decline [GO:0090647]; negative regulation of connective tissue replacement involved in inflammatory response wound healing [GO:1904597]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of long-term synaptic depression [GO:1900453]; negative regulation of long-term synaptic potentiation [GO:1900272]; neuron projection development [GO:0031175]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of astrocyte activation [GO:0061890]; positive regulation of dendritic cell differentiation [GO:2001200]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of monocyte chemotactic protein-1 production [GO:0071639]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to membrane [GO:0072657]; regulation of CD4-positive, alpha-beta T cell activation [GO:2000514]; regulation of DNA binding [GO:0051101]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of NIK/NF-kappaB signaling [GO:1901222]; regulation of p38MAPK cascade [GO:1900744]; regulation of spontaneous synaptic transmission [GO:0150003]; regulation of synaptic plasticity [GO:0048167]; regulation of T cell mediated cytotoxicity [GO:0001914]; response to amyloid-beta [GO:1904645]; response to hypoxia [GO:0001666]; response to wounding [GO:0009611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=10;  Name=1; IsoId=Q15109-1; Sequence=Displayed; Name=2; Synonyms=RAGESEC; IsoId=Q15109-2; Sequence=VSP_002551, VSP_002552; Name=3; IsoId=Q15109-3; Sequence=VSP_042011; Name=4; IsoId=Q15109-4; Sequence=VSP_043528, VSP_042011; Name=5; Synonyms=del exon3-7; IsoId=Q15109-5; Sequence=VSP_047884, VSP_047885; Name=6; IsoId=Q15109-6; Sequence=VSP_043528; Name=7; Synonyms=del exon3; IsoId=Q15109-7; Sequence=VSP_002551; Name=8; IsoId=Q15109-8; Sequence=VSP_047886, VSP_047888; Name=9; Synonyms=del exon8-9; IsoId=Q15109-9; Sequence=VSP_047887, VSP_047889; Name=10; Synonyms=delta-ICD, variant 20; IsoId=Q15109-10; Sequence=VSP_055321; Note=Detected in lung, brain, heart and kidney.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.; SUBCELLULAR LOCATION: Isoform 10: Cell membrane {ECO:0000269|PubMed:24260107}; Single-pass type I membrane protein {ECO:0000269|PubMed:24260107}.


uniprotID: Q53S08
geneSymbol: RAB6D
name: Ras-related protein Rab-6D (Rab6-like protein WTH3DI)
length: 254
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]


uniprotID: Q9H0U4
geneSymbol: RAB1B
reactome: R-HSA-162658;R-HSA-204005;R-HSA-6807878;R-HSA-6811434;R-HSA-8873719;R-HSA-8876198;
pdb: 3JZA;3NKV;4HLQ;4I1O;5O74;5SZH;5SZK;
name: Ras-related protein Rab-1B
length: 201
go: ENSG00000174903;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; phagophore assembly site membrane [GO:0034045]; transport vesicle [GO:0030133]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of glycoprotein metabolic process [GO:1903020]; post-translational protein modification [GO:0043687]; Rab protein signal transduction [GO:0032482]; regulation of autophagosome assembly [GO:2000785]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; virion assembly [GO:0019068]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11389151}. Membrane {ECO:0000269|PubMed:11389151}; Lipid-anchor {ECO:0000269|PubMed:11389151}; Cytoplasmic side {ECO:0000269|PubMed:11389151}. Preautophagosomal structure membrane {ECO:0000269|PubMed:20545908}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). {ECO:0000250}.


uniprotID: Q9Y580
geneSymbol: RBM7
pdb: 2M8H;5IQQ;5LXR;5LXY;
name: RNA-binding protein 7 (RNA-binding motif protein 7)
length: 266
go: ENSG00000076053;
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; meiotic cell cycle [GO:0051321]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21855801}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:21855801}.


uniprotID: P01112
geneSymbol: HRAS
length: 189
go: ENSG00000174775;
drug: DB04315;DB04137;DB03226;
reactome:
R-HSA-112412;R-HSA-1169092;R-HSA-1236382;R-HSA-1250196;R-HSA-1250347;R-HSA-1433557;R-HSA-167044;R-HSA-171007;R-HSA-179812;R-HSA-180336;R-HSA-186763;R-HSA-1963640;R-HSA-210993;R-HSA-2179392;R-HSA-2424491;R-HSA-2428933;R-HSA-2871796;R-HSA-375165;R-HSA-3928662;R-HSA-442982;R-HSA-5218921;R-HSA-5621575;R-HSA-5637810;R-HSA-5654688;R-HSA-5654693;R-HSA-5654699;R-HSA-5654700;R-HSA-5654704;R-HSA-5654706;R-HSA-5654712;R-HSA-5654719;R-HSA-5655253;R-HSA-5655291;R-HSA-5655302;R-HSA-5658442;R-HSA-5673000;R-HSA-5673001;R-HSA-5674135;R-HSA-5675221;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802953;R-HSA-6802955;R-HSA-74751;R-HSA-8849471;R-HSA-8851805;R-HSA-8853334;R-HSA-8853338;R-HSA-9026519;R-HSA-9028731;R-HSA-9034864;

pdb:
121P;1AA9;1AGP;1BKD;1CLU;1CRP;1CRQ;1CRR;1CTQ;1GNP;1GNQ;1GNR;1HE8;1IAQ;1IOZ;1JAH;1JAI;1K8R;1LF0;1LF5;1LFD;1NVU;1NVV;1NVW;1NVX;1P2S;1P2T;1P2U;1P2V;1PLJ;1PLK;1PLL;1Q21;1QRA;1RVD;1WQ1;1XCM;1XD2;1XJ0;1ZVQ;1ZW6;221P;2C5L;2CE2;2CL0;2CL6;2CL7;2CLC;2CLD;2EVW;2GDP;2LCF;2LWI;2N42;2N46;2Q21;2QUZ;2RGA;2RGB;2RGC;2RGD;2RGE;2RGG;2UZI;2VH5;2X1V;3DDC;3I3S;3K8Y;3K9L;3K9N;3KKM;3KKN;3KUD;3L8Y;3L8Z;3LBH;3LBI;3LBN;3LO5;3OIU;3OIV;3OIW;3RRY;3RRZ;3RS0;3RS2;3RS3;3RS4;3RS5;3RS7;3RSL;3RSO;3TGP;421P;4DLR;4DLS;4DLT;4DLU;4DLV;4DLW;4DLX;4DLY;4DLZ;4DST;4DSU;4EFL;4EFM;4EFN;4G0N;4G3X;4K81;4L9S;4L9W;4NYI;4NYJ;4NYM;4Q21;4RSG;4URU;4URV;4URW;4URX;4URY;4URZ;4US0;4US1;4US2;4XVQ;4XVR;521P;5B2Z;5B30;5E95;5P21;5VBE;5VBZ;5WDO;5WDP;5WDQ;5WFO;5WFP;5WFQ;5WFR;5WPL;5X9S;5ZC6;621P;6AMB;6AXG;6D55;6D56;6D59;6D5E;6D5G;6D5H;6D5J;6D5L;6D5M;6D5V;6Q21;721P;821P;

name:
GTPase HRas (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]

sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein C-terminus binding [GO:0008022]; animal organ morphogenesis [GO:0009887]; cell cycle arrest [GO:0007050]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; cellular response to gamma radiation [GO:0071480]; cellular senescence [GO:0090398]; chemotaxis [GO:0006935]; defense response to protozoan [GO:0042832]; endocytosis [GO:0006897]; ephrin receptor signaling pathway [GO:0048013]; intrinsic apoptotic signaling pathway [GO:0097193]; MAPK cascade [GO:0000165]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of GTPase activity [GO:0034260]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA replication [GO:0045740]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of miRNA metabolic process [GO:2000630]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein targeting to membrane [GO:0090314]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of ruffle assembly [GO:1900029]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of wound healing [GO:0090303]; protein heterooligomerization [GO:0051291]; Ras protein signal transduction [GO:0007265]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane [GO:0098696]; response to isolation stress [GO:0035900]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell receptor signaling pathway [GO:0050852]; T-helper 1 type immune response [GO:0042088]

snps:
rs104894230 rs104894229 rs104894230 rs104894229 rs104894230 rs104894228 rs104894226 rs104894228 rs121917757 rs121917758 rs28933406 rs121913233 rs121917756 rs755322824 rs104894227 rs104894231 rs121917759 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=H-Ras4A, p21; IsoId=P01112-1; Sequence=Displayed; Name=2; Synonyms=H-RasIDX, p19; IsoId=P01112-2; Sequence=VSP_041597; 

location:
SUBCELLULAR LOCATION: Cell membrane. Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus. Golgi apparatus membrane; Lipid-anchor. Note=The active GTP-bound form is localized most strongly to membranes than the inactive GDP-bound form (By similarity). Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with RACK1 to the perinuclear region.


uniprotID: Q15434
geneSymbol: RBMS2
pdb: 1X4E;
length: 407
go: ENSG00000076067;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
RNA-binding motif, single-stranded-interacting protein 2 (Suppressor of CDC2 with RNA-binding motif 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; RNA processing [GO:0006396]


uniprotID: P13631
geneSymbol: RARG
reactome: R-HSA-383280;R-HSA-5362517;R-HSA-5617472;
pdb: 1EXA;1EXX;1FCX;1FCY;1FCZ;1FD0;2LBD;3LBD;4LBD;5M24;6FX0;
name: Retinoic acid receptor gamma (RAR-gamma) (Nuclear receptor subfamily 1 group B member 3)
length: 454
go: ENSG00000172819;
drug: DB00459;DB00210;DB00523;DB03466;DB02741;DB03279;DB00926;DB05785;DB05467;DB02258;DB00799;DB00755;
snps: rs2229774
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
integral component of membrane [GO:0016021]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; transcription factor complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor transcription coactivator activity [GO:0030374]; retinoic acid receptor activity [GO:0003708]; retinoid X receptor binding [GO:0046965]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; signaling receptor activity [GO:0038023]; steroid hormone receptor activity [GO:0003707]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270]; anterior/posterior pattern specification [GO:0009952]; bone morphogenesis [GO:0060349]; canonical Wnt signaling pathway [GO:0060070]; cell differentiation [GO:0030154]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to retinoic acid [GO:0071300]; embryonic camera-type eye development [GO:0031076]; embryonic eye morphogenesis [GO:0048048]; embryonic hindlimb morphogenesis [GO:0035116]; epithelium development [GO:0060429]; face development [GO:0060324]; gland development [GO:0048732]; glandular epithelial cell development [GO:0002068]; growth plate cartilage chondrocyte growth [GO:0003430]; Harderian gland development [GO:0070384]; hormone-mediated signaling pathway [GO:0009755]; multicellular organism development [GO:0007275]; multicellular organism growth [GO:0035264]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube closure [GO:0001843]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell proliferation [GO:0008284]; positive regulation of programmed cell death [GO:0043068]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prostate gland epithelium morphogenesis [GO:0060740]; regulation of cell size [GO:0008361]; regulation of myelination [GO:0031641]; regulation of myeloid cell differentiation [GO:0045637]; response to lipid [GO:0033993]; response to retinoic acid [GO:0032526]; retinoic acid receptor signaling pathway [GO:0048384]; trachea cartilage development [GO:0060534]; transcription initiation from RNA polymerase II promoter [GO:0006367]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Isoforms differ only in their N-terminal regions.; Name=1; IsoId=P13631-1; Sequence=Displayed; Name=2; IsoId=P13631-2; Sequence=VSP_031080; Name=3; IsoId=P13631-3; Sequence=VSP_044777; Note=No experimental confirmation available.; Name=4; IsoId=P13631-4; Sequence=VSP_044776; Note=No experimental confirmation available.; 


uniprotID: P49792
geneSymbol: RANBP2
pdb: 1RRP;1XKE;1Z5S;2LAS;3UIN;3UIO;3UIP;4GA0;4I9Y;4L6E;4LQW;5CLL;5CLQ;
length: 3224
go: ENSG00000153201;
reactome:
R-HSA-1169408;R-HSA-141444;R-HSA-159227;R-HSA-159230;R-HSA-159231;R-HSA-159236;R-HSA-165054;R-HSA-168271;R-HSA-168276;R-HSA-168325;R-HSA-168333;R-HSA-170822;R-HSA-180746;R-HSA-180910;R-HSA-191859;R-HSA-2467813;R-HSA-2500257;R-HSA-3108214;R-HSA-3232142;R-HSA-3301854;R-HSA-3371453;R-HSA-4085377;R-HSA-4551638;R-HSA-4570464;R-HSA-4615885;R-HSA-5578749;R-HSA-5663220;R-HSA-6784531;R-HSA-68877;

name:
E3 SUMO-protein ligase RanBP2 (EC 2.3.2.-) (358 kDa nucleoporin) (Nuclear pore complex protein Nup358) (Nucleoporin Nup358) (Ran-binding protein 2) (RanBP2) (p270)

sequence:

opentargets:
annulate lamellae [GO:0005642]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nuclear pore nuclear basket [GO:0044615]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; Ran GTPase binding [GO:0008536]; RNA binding [GO:0003723]; SUMO transferase activity [GO:0019789]; centrosome localization [GO:0051642]; mRNA export from nucleus [GO:0006406]; NLS-bearing protein import into nucleus [GO:0006607]; positive regulation of glucokinase activity [GO:0033133]; positive regulation of GTPase activity [GO:0043547]; protein folding [GO:0006457]; protein peptidyl-prolyl isomerization [GO:0000413]; protein sumoylation [GO:0016925]; regulation of gluconeogenesis [GO:0006111]; response to amphetamine [GO:0001975]; viral process [GO:0016032]

snps:
rs1057954 rs1057956 rs1057957 rs121434502 rs121434503 rs121434504 rs17414315 rs2912838 rs2889846 rs12770 rs12770 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7775481}. Nucleus membrane {ECO:0000269|PubMed:11839768}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:23353830, ECO:0000269|PubMed:7603572}. Nucleus envelope {ECO:0000269|PubMed:20386726}. Note=Detected in diffuse and discrete intranuclear foci (PubMed:11839768). Cytoplasmic filaments (PubMed:7775481). {ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:7775481}.


uniprotID: A6NK89
geneSymbol: RASSF10
name: Ras association domain-containing protein 10
length: 507
go: ENSG00000189431;
snps: rs4323847
sequence:

opentargets:
cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; spindle pole [GO:0000922]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of neurogenesis [GO:0050769]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20956940}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20956940}. Note=During interphase, predominantly cytoplasmic, although some nuclear staining in several tumor cell contexts. During prophase, observed at developing centrosomes. Displays persistent localization with centrosomally radiating microtubule bundles until late telophase. Associates with spindle poles particularly during metaphase and anaphase before relocating back to the cytoplasm.


uniprotID: O75943
geneSymbol: RAD17
reactome: R-HSA-176187;R-HSA-5685938;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;
name: Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
length: 681
go: ENSG00000152942;
snps: rs17229831 rs17236478 rs17236485 rs1045051
sequence:

opentargets:
nuclear chromatin [GO:0000790]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad17 RFC-like complex [GO:0031389]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA clamp loader activity [GO:0003689]; cellular response to DNA damage stimulus [GO:0006974]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication checkpoint [GO:0000076]; mitotic cell cycle checkpoint [GO:0007093]; mitotic DNA replication checkpoint [GO:0033314]; negative regulation of DNA replication [GO:0008156]; regulation of phosphorylation [GO:0042325]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Rad17Sp, FM2; IsoId=O75943-1; Sequence=Displayed; Name=2; Synonyms=Rad17Sp2, FM1; IsoId=O75943-2; Sequence=VSP_013308; Name=3; Synonyms=FM3; IsoId=O75943-3; Sequence=VSP_013306; Name=4; Synonyms=FM4; IsoId=O75943-4; Sequence=VSP_013307, VSP_013309; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10232579, ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:11799063, ECO:0000269|PubMed:12400013}. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.


uniprotID: Q9Y5P3
geneSymbol: RAI2
name: Retinoic acid-induced protein 2
length: 530
go: ENSG00000131831;
opentargets: embryo development ending in birth or egg hatching [GO:0009792]
snps: rs6527818 rs17855524
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5P3-1; Sequence=Displayed; Name=2; IsoId=Q9Y5P3-2; Sequence=VSP_047524; Note=No experimental confirmation available.; 


uniprotID: P01111
geneSymbol: NRAS
pdb: 2N9C;3CON;5UHV;
name: GTPase NRas (Transforming protein N-Ras)
length: 189
go: ENSG00000213281;
reactome:
R-HSA-112412;R-HSA-1169092;R-HSA-1236382;R-HSA-1250196;R-HSA-1250347;R-HSA-1433557;R-HSA-167044;R-HSA-171007;R-HSA-179812;R-HSA-180336;R-HSA-186763;R-HSA-1963640;R-HSA-210993;R-HSA-2179392;R-HSA-2424491;R-HSA-2428933;R-HSA-2871796;R-HSA-375165;R-HSA-5218921;R-HSA-5621575;R-HSA-5637810;R-HSA-5654688;R-HSA-5654693;R-HSA-5654699;R-HSA-5654700;R-HSA-5654704;R-HSA-5654706;R-HSA-5654712;R-HSA-5654719;R-HSA-5655253;R-HSA-5655291;R-HSA-5655302;R-HSA-5658442;R-HSA-5673000;R-HSA-5673001;R-HSA-5674135;R-HSA-5675221;R-HSA-6798695;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802953;R-HSA-6802955;R-HSA-74751;R-HSA-8849471;R-HSA-8851805;R-HSA-8853334;R-HSA-8853338;R-HSA-9026519;R-HSA-9028731;R-HSA-9034864;

sequence:
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM

opentargets:
extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein-containing complex binding [GO:0044877]; MAPK cascade [GO:0000165]; neutrophil degranulation [GO:0043312]; positive regulation of endothelial cell proliferation [GO:0001938]; Ras protein signal transduction [GO:0007265]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]

snps:
rs121913250 rs121913237 rs121434596 rs121434595 rs397514553 rs267606921 rs267606920 rs121913254 rs11554290 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}. Golgi apparatus membrane {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}.


uniprotID: Q86YS6
geneSymbol: RAB43
reactome: R-HSA-6811440;R-HSA-8873719;
pdb: 2HUP;
name: Ras-related protein Rab-43 (Ras-related protein Rab-41)
length: 212
go: ENSG00000172780;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; trans-Golgi network membrane [GO:0032588]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to interferon-gamma [GO:0071346]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; phagosome maturation [GO:0090382]; Rab protein signal transduction [GO:0032482]; retrograde transport, plasma membrane to Golgi [GO:0035526]; toxin transport [GO:1901998]; virion assembly [GO:0019068]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86YS6-1; Sequence=Displayed; Name=2; Synonyms=ISY1-RAB43; IsoId=Q9ULR0-1; Sequence=External; Note=Based on a readthrough transcript which may produce a ISY1-RAB43 fusion protein. No experimental confirmation available.; Name=3; IsoId=Q86YS6-2; Sequence=VSP_054030, VSP_054031; Note=Gene prediction based on EST data. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:17562788, ECO:0000269|PubMed:18664496}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:17562788}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.


uniprotID: Q8IUH3
geneSymbol: RBM45
length: 476
go: ENSG00000155636;
name:
RNA-binding protein 45 (Developmentally-regulated RNA-binding protein 1) (RB-1) (RNA-binding motif protein 45)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000269|PubMed:12220514}; IsoId=Q8IUH3-1; Sequence=Displayed; Name=2; IsoId=Q8IUH3-2; Sequence=VSP_021005, VSP_051661, VSP_051662; Note=May be due to an intron retention. {ECO:0000305}; Name=3; IsoId=Q8IUH3-3; Sequence=VSP_021005; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12220514}. Nucleus {ECO:0000269|PubMed:12220514}. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.


uniprotID: O75901
geneSymbol: RASSF9
length: 435
go: ENSG00000198774;
snps: rs7397266
location: SUBCELLULAR LOCATION: Endosome. Note=Accumulates on perinuclear endosomes. {ECO:0000250}.
name:
Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)

sequence:

opentargets:
cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; recycling endosome [GO:0055037]; trans-Golgi network transport vesicle membrane [GO:0012510]; transporter activity [GO:0005215]; endosomal transport [GO:0016197]; intracellular transport [GO:0046907]; protein targeting [GO:0006605]; signal transduction [GO:0007165]


uniprotID: Q86YV0
geneSymbol: RASAL3
reactome: R-HSA-5658442;R-HSA-6802949;
name: RAS protein activator like-3
length: 1011
go: ENSG00000105122;
snps: rs58123634 rs56209154 rs57208996
sequence:

opentargets:
cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic side of membrane [GO:0098562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; MAPK cascade [GO:0000165]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of NK T cell proliferation [GO:0051142]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86YV0-1; Sequence=Displayed; Name=2; IsoId=Q86YV0-2; Sequence=VSP_033824; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25652366}. Cytoplasm, cell cortex {ECO:0000269|PubMed:25652366}.


uniprotID: Q6ZTQ3
geneSymbol: RASSF6
name: Ras association domain-containing protein 6
length: 369
go: ENSG00000169435;
snps: rs12507775 rs17804499
sequence:

opentargets:
apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZTQ3-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q6ZTQ3-2; Sequence=VSP_019370; Name=3; Synonyms=B; IsoId=Q6ZTQ3-3; Sequence=VSP_019371; Name=4; IsoId=Q6ZTQ3-4; Sequence=VSP_019370, VSP_019372; 


uniprotID: Q9NXS2
geneSymbol: QPCTL
pdb: 3PB4;3PB6;3PB7;3PB8;3PB9;
length: 382
go: ENSG00000011478;
snps: rs28708996
name:
Glutaminyl-peptide cyclotransferase-like protein (EC 2.3.2.5) (Golgi-resident glutaminyl-peptide cyclotransferase) (isoQC) (gQC)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; glutaminyl-peptide cyclotransferase activity [GO:0016603]; zinc ion binding [GO:0008270]; peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase [GO:0017186]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NXS2-1; Sequence=Displayed; Name=2; IsoId=Q9NXS2-3; Sequence=VSP_054066; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18486145}; Single-pass type I membrane protein {ECO:0000269|PubMed:18486145}.


uniprotID: Q96IS3
geneSymbol: RAX2
length: 184
go: ENSG00000173976;
snps: rs121908280 rs121908281
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
name:
Retina and anterior neural fold homeobox protein 2 (Q50-type retinal homeobox protein) (Retina and anterior neural fold homeobox-like protein 1)

sequence:
MFLSPGEGPATEGGGLGPGEEAPKKKHRRNRTTFTTYQLHQLERAFEASHYPDVYSREELAAKVHLPEVRVQVWFQNRRAKWRRQERLESGSGAVAAPRLPEAPALPFARPPAMSLPLEPWLGPGPPAVPGLPRLLGPGPGLQASFGPHAFAPTFADGFALEEASLRLLAKEHAQALDRAWPPA

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to stimulus [GO:0050896]; visual perception [GO:0007601]


uniprotID: P52756
geneSymbol: RBM5
reactome: R-HSA-72163;
pdb: 2LK0;2LK1;2LKZ;5MF9;5MFY;
length: 815
go: ENSG00000003756;
snps: rs56783610
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18851835}.
name:
RNA-binding protein 5 (Protein G15) (Putative tumor suppressor LUCA15) (RNA-binding motif protein 5) (Renal carcinoma antigen NY-REN-9)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA processing [GO:0006396]; spliceosomal complex assembly [GO:0000245]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P52756-1; Sequence=Displayed; Name=2; IsoId=P52756-2; Sequence=VSP_037432, VSP_037434; Name=3; IsoId=P52756-3; Sequence=VSP_037429, VSP_037430; Note=No experimental confirmation available.; Name=4; IsoId=P52756-4; Sequence=VSP_037433; Note=No experimental confirmation available.; Name=5; Synonyms=delta-6; IsoId=P52756-5; Sequence=VSP_037431, VSP_037435; 


uniprotID: P98179
geneSymbol: RBM3
name: RNA-binding protein 3 (RNA-binding motif protein 3) (RNPL)
length: 157
go: ENSG00000102317;
sequence:
MSSEEGKLFVGGLNFNTDEQALEDHFSSFGPISEVVVVKDRETQRSRGFGFITFTNPEHASVAMRAMNGESLDGRQIRVDHAGKSARGTRGGGFGAHGRGRSYSRGGGDQGYGSGRYYDSRPGGYGYGYGRSRDYNGRNQGGYDRYSGGNYRDNYDN

opentargets:
cytoplasm [GO:0005737]; dendrite [GO:0030425]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; mRNA 3'-UTR binding [GO:0003730]; poly(U) RNA binding [GO:0008266]; ribosomal large subunit binding [GO:0043023]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; translation repressor activity [GO:0030371]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of translation [GO:0045727]; regulation of translation [GO:0006417]; response to cold [GO:0009409]; RNA processing [GO:0006396]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes in mRNA granules in dentrites. {ECO:0000250}.


uniprotID: Q96P65
geneSymbol: QRFPR
reactome: R-HSA-389397;R-HSA-416476;
length: 431
go: ENSG00000186867;
snps: rs17438900 rs11947418 rs2302310
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Pyroglutamylated RF-amide peptide receptor (AQ27) (G-protein coupled receptor 103) (Orexigenic neuropeptide QRFP receptor) (SP9155)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide Y receptor activity [GO:0004983]; G protein-coupled receptor signaling pathway [GO:0007186]


uniprotID: P61578
geneSymbol: ERVK-16
name: Endogenous retrovirus group K member 16 Rec protein (HERV-K_10p14 provirus Rec protein)
length: 105
sequence:
MNPSEMQRKAPPRRRRHRNRAPSSHKMNKMMMSEEQMKLPSTNKAEPLTWAQLNKLTQLATKCLENTKMTQTPESMLLAALMIVSTVSAGVPNSSEETVTIENGP

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.


uniprotID: P46063
geneSymbol: RECQL
pdb: 2V1X;2WWY;4U7D;
length: 649
go: ENSG00000004700;
snps: rs1065751 rs2230003 rs6501 rs6499
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7961977}.
name:
ATP-dependent DNA helicase Q1 (EC 3.6.4.12) (DNA helicase, RecQ-like type 1) (RecQ1) (DNA-dependent ATPase Q1) (RecQ protein-like 1)

sequence:

opentargets:
chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; annealing helicase activity [GO:0036310]; ATP binding [GO:0005524]; ATP-dependent 3'-5' DNA helicase activity [GO:0043140]; ATP-dependent DNA helicase activity [GO:0004003]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; four-way junction helicase activity [GO:0009378]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA strand renaturation [GO:0000733]; double-strand break repair via homologous recombination [GO:0000724]


uniprotID: Q9H0H5
geneSymbol: RACGAP1
reactome: R-HSA-194840;R-HSA-2132295;R-HSA-6811434;R-HSA-983189;
pdb: 2OVJ;3W6R;3WPQ;3WPS;4B6D;5C2J;5C2K;
length: 632
go: ENSG00000161800;
name:
Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; centralspindlin complex [GO:0097149]; cleavage furrow [GO:0032154]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; Flemming body [GO:0090543]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle midzone [GO:0051233]; alpha-tubulin binding [GO:0043014]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; protein kinase binding [GO:0019901]; actomyosin contractile ring assembly [GO:0000915]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; intracellular signal transduction [GO:0035556]; microtubule-based movement [GO:0007018]; mitotic cytokinesis [GO:0000281]; mitotic spindle midzone assembly [GO:0051256]; neuroblast proliferation [GO:0007405]; positive regulation of cytokinesis [GO:0032467]; regulation of attachment of spindle microtubules to kinetochore [GO:0051988]; regulation of embryonic development [GO:0045995]; regulation of small GTPase mediated signal transduction [GO:0051056]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; spermatogenesis [GO:0007283]; sulfate transport [GO:0008272]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. {ECO:0000250}.


uniprotID: O76081
geneSymbol: RGS20
reactome: R-HSA-418594;R-HSA-418597;
length: 388
go: ENSG00000147509;
name:
Regulator of G-protein signaling 20 (RGS20) (Gz-selective GTPase-activating protein) (G(z)GAP) (Gz-GAP) (Regulator of G-protein signaling Z1) (Regulator of Gz-selective protein signaling 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; GTPase activator activity [GO:0005096]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=6; IsoId=O76081-1; Sequence=Displayed; Name=1; IsoId=O76081-2; Sequence=VSP_005696; Name=2; IsoId=O76081-3; Sequence=VSP_005697, VSP_005699; Name=3; IsoId=O76081-4; Sequence=VSP_005698, VSP_005700; Name=4; IsoId=O76081-5; Sequence=VSP_005695, VSP_005696; Name=5; IsoId=O76081-6; Sequence=VSP_005694, VSP_005696; 

location:
SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.


uniprotID: Q9H4X1
geneSymbol: RGCC
reactome: R-HSA-6804115;
name: Regulator of cell cycle RGCC (Response gene to complement 32 protein) (RGC-32)
length: 137
go: ENSG00000102760;
sequence:
MKPPAAQGSPAAAAAAAPALDSAAAEDLSDALCEFDAVLADFASPFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRNSFSFSDEKLNSPTDSTPALLSATVTPQKAKLGDTKELEAFIADLDKTLASM

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; R-SMAD binding [GO:0070412]; cellular response to hypoxia [GO:0071456]; complement activation [GO:0006956]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; fibroblast activation [GO:0072537]; mitotic cell cycle arrest [GO:0071850]; negative regulation of angiogenesis [GO:0016525]; negative regulation of blood vessel endothelial cell migration [GO:0043537]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of exit from mitosis [GO:0001100]; negative regulation of fibroblast growth factor production [GO:0090272]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of extracellular matrix constituent secretion [GO:0003331]; positive regulation of gene expression [GO:0010628]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H4X1-1; Sequence=Displayed; Name=2; IsoId=Q9H4X1-2; Sequence=VSP_022873; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.


uniprotID: P57771
geneSymbol: RGS8
reactome: R-HSA-418594;
pdb: 2IHD;2ODE;5DO9;
name: Regulator of G-protein signaling 8 (RGS8)
length: 180
go: ENSG00000135824;
sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

opentargets:
dendrite [GO:0030425]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; neuronal cell body membrane [GO:0032809]; nucleus [GO:0005634]; perikaryon [GO:0043204]; GTPase activator activity [GO:0005096]; G protein-coupled acetylcholine receptor signaling pathway [GO:0007213]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of dopamine receptor signaling pathway [GO:0060159]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P57771-1; Sequence=Displayed; Name=2; IsoId=P57771-2; Sequence=VSP_036421; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Membrane {ECO:0000250|UniProtKB:P49804}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49804}; Cytoplasmic side {ECO:0000250|UniProtKB:P49804}. Perikaryon {ECO:0000250|UniProtKB:P49804}. Cell projection, dendrite {ECO:0000250|UniProtKB:P49804}. Nucleus {ECO:0000250|UniProtKB:P49804}. Note=Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1. {ECO:0000250|UniProtKB:P49804}.


uniprotID: Q9NX52
geneSymbol: RHBDL2
length: 303
go: ENSG00000158315;
snps: rs2147914
name:
Rhomboid-related protein 2 (RRP2) (EC 3.4.21.105) (Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment (NTF); Rhomboid-related protein 2, C-terminal fragment (CTF)]

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NX52-1; Sequence=Displayed; Name=2; IsoId=Q9NX52-3; Sequence=VSP_012692; Note=May be due to an intron retention. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Rhomboid-related protein 2, C-terminal fragment: Cell membrane {ECO:0000269|PubMed:19850051}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q02161
geneSymbol: RHD
length: 417
go: ENSG00000187010;
name:
Blood group Rh(D) polypeptide (RHXIII) (Rh polypeptide 2) (RhPII) (Rhesus D antigen) (CD antigen CD240D)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; ammonium transmembrane transporter activity [GO:0008519]; ammonium transmembrane transport [GO:0072488]

snps:
rs772865539 rs121912762 rs1053352 rs1053355 rs141540728 rs1053356 rs1053359 rs1053360 rs150073306 rs3118454 rs590813 rs590787 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=Long; IsoId=Q02161-1; Sequence=Displayed; Name=2; Synonyms=Short 1; IsoId=Q02161-2; Sequence=VSP_005706; Name=3; Synonyms=Short 2; IsoId=Q02161-3; Sequence=VSP_005707, VSP_005708; Name=4; IsoId=Q02161-4; Sequence=VSP_047797; Name=5; IsoId=Q02161-5; Sequence=VSP_047796; Name=6; IsoId=Q02161-6; Sequence=VSP_047795, VSP_047798; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1544931, ECO:0000269|PubMed:3142870}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q15382
geneSymbol: RHEB
reactome: R-HSA-1632852;R-HSA-165159;R-HSA-166208;R-HSA-380972;R-HSA-5628897;R-HSA-8943724;
pdb: 1XTQ;1XTR;1XTS;3SEA;3T5G;5YXH;6BCU;6BSX;6BT0;
name: GTP-binding protein Rheb (Ras homolog enriched in brain)
length: 184
go: ENSG00000106615;
drug: DB04315;DB04137;
sequence:
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFRRIILEAEKMDGAASQGKSSCSVM

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; spliceosomal complex [GO:0005681]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; protein kinase binding [GO:0019901]; cell cycle arrest [GO:0007050]; negative regulation of cold-induced thermogenesis [GO:0120163]; positive regulation of oligodendrocyte differentiation [GO:0048714]; positive regulation of TOR signaling [GO:0032008]; regulation of macroautophagy [GO:0016241]; regulation of type B pancreatic cell development [GO:2000074]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:22002721, ECO:0000305}; Lipid-anchor {ECO:0000269|PubMed:22002721, ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:15489334, ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000305|PubMed:22002721}; Cytoplasmic side {ECO:0000305|PubMed:22002721}. Cytoplasm, cytosol {ECO:0000269|PubMed:22002721}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22002721}; Lipid-anchor {ECO:0000269|PubMed:22002721}; Cytoplasmic side {ECO:0000269|PubMed:22002721}.


uniprotID: Q96QB1
geneSymbol: DLC1
reactome: R-HSA-194840;
pdb: 2DKY;2GYT;2KAP;2LOZ;3KUQ;5FZT;
length: 1528
go: ENSG00000164741;
name:
Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)

sequence:

opentargets:
caveola [GO:0005901]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; ruffle membrane [GO:0032587]; GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; SH2 domain binding [GO:0042169]; actin cytoskeleton organization [GO:0030036]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; focal adhesion assembly [GO:0048041]; forebrain development [GO:0030900]; heart morphogenesis [GO:0003007]; hindbrain morphogenesis [GO:0021575]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; neural tube closure [GO:0001843]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

snps:
rs34575560 rs3816748 rs11203495 rs11203494 rs3816747 rs34591797 rs1044092 rs532841 rs121908500 rs149295187 rs1044093 rs1044094 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=6;  Name=2; IsoId=Q96QB1-2; Sequence=Displayed; Name=1; IsoId=Q96QB1-1; Sequence=VSP_037871, VSP_037872; Name=3; IsoId=Q96QB1-3; Sequence=VSP_037873, VSP_037874; Name=4; IsoId=Q96QB1-4; Sequence=VSP_037871, VSP_044651; Note=No experimental confirmation available.; Name=5; IsoId=Q96QB1-5; Sequence=VSP_046331, VSP_046332; Note=No experimental confirmation available.; Name=6; Synonyms=i-4; IsoId=Q96QB1-6; Sequence=VSP_053836, VSP_053837; Note=Produced by alternative promoter usage. ubiquitously expressed, significantly down-regulated in multiple carcinoma cell lines. Ref.8 (ABX83661/ABX83662) sequences are in conflict in positions: 49-50:EA->KP.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Note=Colocalizes with EF1A1 at actin-rich regions in the cell periphery.


uniprotID: Q96CC6
geneSymbol: RHBDF1
length: 855
go: ENSG00000007384;
snps: rs3213511
name:
Inactive rhomboid protein 1 (iRhom1) (Epidermal growth factor receptor-related protein) (Rhomboid 5 homolog 1) (Rhomboid family member 1) (p100hRho)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; growth factor binding [GO:0019838]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; negative regulation of protein secretion [GO:0050709]; protein transport [GO:0015031]; proteolysis [GO:0006508]; regulation of epidermal growth factor receptor signaling pathway [GO:0042058]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of protein secretion [GO:0050708]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597, ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15965977, ECO:0000269|PubMed:18832597}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localized in the endoplasmic reticulum membrane (PubMed:15965977). {ECO:0000269|PubMed:15965977}.


uniprotID: Q9HBH0
geneSymbol: RHOF
reactome: R-HSA-194840;R-HSA-6798695;
name: Rho-related GTP-binding protein RhoF (Rho family GTPase Rif) (Rho in filopodia)
length: 211
go: ENSG00000139725;
sequence:

opentargets:
cell cortex [GO:0005938]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; neutrophil degranulation [GO:0043312]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HBH0-1; Sequence=Displayed; Name=2; IsoId=Q9HBH0-2; Sequence=VSP_013571, VSP_013572; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton.


uniprotID: P27635
geneSymbol: RPL10
pdb: 2PA2;5AJ0;
length: 214
snps: rs4909
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-6791226;R-HSA-72689;R-HSA-72706;R-HSA-72764;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

name:
60S ribosomal protein L10 (Laminin receptor homolog) (Large ribosomal subunit protein uL16) (Protein QM) (Ribosomal protein L10) (Tumor suppressor QM)

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation regulator activity [GO:0045182]; embryonic brain development [GO:1990403]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translation [GO:0006417]; ribosomal large subunit assembly [GO:0000027]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P61587
geneSymbol: RND3
pdb: 1M7B;2V55;4BG6;
length: 244
go: ENSG00000115963;
drug: DB04137;
location: SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein.
name:
Rho-related GTP-binding protein RhoE (Protein MemB) (Rho family GTPase 3) (Rho-related GTP-binding protein Rho8) (Rnd3)

sequence:

opentargets:
cell cortex [GO:0005938]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]


uniprotID: P62913
geneSymbol: RPL11
pdb: 4UG0;4V6X;4XXB;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L11 (CLL-associated antigen KW-12) (Large ribosomal subunit protein uL5)
length: 178
go: ENSG00000142676;
drug: DB02494;DB07374;DB08437;
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-6791226;R-HSA-72689;R-HSA-72706;R-HSA-72764;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

sequence:
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; protein-containing complex [GO:0032991]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]; cytoplasmic translation [GO:0002181]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of protein binding [GO:0032092]; protein localization to nucleus [GO:0034504]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P62913-1, P39026-1; Sequence=Displayed; Name=2; IsoId=P62913-2, P39026-2; Sequence=VSP_008320; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:27829214}. Cytoplasm {ECO:0000250|UniProtKB:Q9CXW4}.


uniprotID: Q9UBS8
geneSymbol: RNF14
reactome: R-HSA-983168;
length: 474
go: ENSG00000013561;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9853615}. Nucleus {ECO:0000269|PubMed:9853615}.
name:
E3 ubiquitin-protein ligase RNF14 (EC 2.3.2.31) (Androgen receptor-associated protein 54) (HFB30) (RING finger protein 14) (Triad2 protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]; androgen receptor binding [GO:0050681]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; androgen receptor signaling pathway [GO:0030521]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of transcription, DNA-templated [GO:0045893]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of androgen receptor signaling pathway [GO:0060765]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UBS8-1; Sequence=Displayed; Name=2; IsoId=Q9UBS8-2; Sequence=VSP_045780; Note=No experimental confirmation available.; 


uniprotID: Q5M7Z0
geneSymbol: RNFT1
length: 435
go: ENSG00000189050;
name:
E3 ubiquitin-protein ligase RNFT1 (EC 2.3.2.27) (Protein PTD016) (RING finger and transmembrane domain-containing protein 1)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5M7Z0-1; Sequence=Displayed; Name=2; IsoId=Q5M7Z0-2; Sequence=VSP_031698, VSP_031699; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=Q5M7Z0-3; Sequence=VSP_031700, VSP_031701; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: P50914
geneSymbol: RPL14
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L14 (CAG-ISL 7) (Large ribosomal subunit protein eL14)
length: 215
go: ENSG00000188846;
snps: rs929099541
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-6791226;R-HSA-72689;R-HSA-72706;R-HSA-72764;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; postsynaptic density [GO:0014069]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q5VYX0
geneSymbol: RNLS
reactome: R-HSA-197264;
pdb: 3QJ4;
name: Renalase (EC 1.6.3.5) (Monoamine oxidase-C) (MAO-C)
length: 342
go: ENSG00000184719;
snps: rs2296545
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15841207}.
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; epinephrine binding [GO:0051379]; monoamine oxidase activity [GO:0097621]; NADH binding [GO:0070404]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of blood pressure [GO:0045776]; negative regulation of heart rate [GO:0010459]; oxidation-reduction process [GO:0055114]; response to epinephrine [GO:0071871]; response to ischemia [GO:0002931]; response to salt [GO:1902074]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5VYX0-1; Sequence=Displayed; Name=2; IsoId=Q5VYX0-2; Sequence=VSP_015211, VSP_015212; Note=No experimental confirmation available.; 


uniprotID: Q9NRW1
geneSymbol: RAB6B
reactome: R-HSA-6811436;R-HSA-6811440;R-HSA-8854214;R-HSA-8873719;R-HSA-8876198;
pdb: 2E9S;2FE4;2FFQ;
name: Ras-related protein Rab-6B
length: 208
go: ENSG00000154917;
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; presynapse [GO:0098793]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NRW1-1; Sequence=Displayed; Name=2; IsoId=Q9NRW1-2; Sequence=VSP_055831; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:18044744}; Lipid-anchor {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17707369}. Cytoplasmic vesicle {ECO:0000269|PubMed:17707369}. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. {ECO:0000269|PubMed:17707369}.


uniprotID: Q6ZRY4
geneSymbol: RBPMS2
pdb: 2M9K;
name: RNA-binding protein with multiple splicing 2
length: 209
go: ENSG00000166831;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25064856}.
sequence:

opentargets:
cytoplasm [GO:0005737]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; snRNA stem-loop binding [GO:0035614]; embryonic digestive tract morphogenesis [GO:0048557]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of smooth muscle cell differentiation [GO:0051151]; positive regulation of smooth muscle cell proliferation [GO:0048661]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZRY4-1; Sequence=Displayed; Name=2; IsoId=Q6ZRY4-2; Sequence=VSP_056896; Note=No experimental confirmation available.; 


uniprotID: Q7Z3Z2
geneSymbol: RD3
name: Protein RD3 (Retinal degeneration protein 3)
length: 195
go: ENSG00000198570;
sequence:
MSLISWLRWNEAPSRLSTRSPAEMVLETLMMELTGQMREAERQQRERSNAVRKVCTGVDYSWLASTPRSTYDLSPIERLQLEDVCVKIHPSYCGPAILRFRQLLAEQEPEVQEVSQLFRSVLQEVLERMKQEEEAHKLTRQWSLRPRGSLATFKTRARISPFASDIRTISEDVERDTPPPLRSWSMPEFRAPKAD

opentargets:
response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]

snps:
rs35649846 rs34422496 rs530024772 rs34049451 rs767481165 rs144697496 rs766015590 rs74782684 rs143207434 


uniprotID: P61575
geneSymbol: ERVK-8
length: 105
name:
Endogenous retrovirus group K member 8 Rec protein (HERV-K115 Rec protein) (HERV-K_8p23.1 provirus Rec protein)

sequence:
MNPSEMQRKAPPRRRRHRNRAPLTHKMNKMVTSEEQMKLPSTKKAEPPTWAQLKKLTQLATKYLENTKVTQTPESMLLAALMIVSMVSAGVLNSSEETATIENGP

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; mRNA transport [GO:0051028]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm. When in the nucleus, resides in the nucleolus (By similarity). {ECO:0000250}.


uniprotID: O95980
geneSymbol: RECK
reactome: R-HSA-163125;
length: 971
go: ENSG00000122707;
snps: rs16932912
name:
Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) (Suppressor of tumorigenicity 15 protein)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; endopeptidase inhibitor activity [GO:0004866]; metalloendopeptidase inhibitor activity [GO:0008191]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood vessel maturation [GO:0001955]; embryo implantation [GO:0007566]; embryonic forelimb morphogenesis [GO:0035115]; extracellular matrix organization [GO:0030198]; negative regulation of cell migration [GO:0030336]; negative regulation of metalloendopeptidase activity [GO:1904684]; regulation of canonical Wnt signaling pathway [GO:0060828]; sprouting angiogenesis [GO:0002040]; vasculature development [GO:0001944]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:9789069}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:9789069}.


uniprotID: O14593
geneSymbol: RFXANK
pdb: 3UXG;3V30;4QQM;
length: 260
go: ENSG00000064490;
snps: rs34282046 rs751386365 rs1802498
name:
DNA-binding protein RFXANK (Ankyrin repeat family A protein 1) (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein)

sequence:

opentargets:
cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; histone deacetylase binding [GO:0042826]; transcription coregulator activity [GO:0003712]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Long; IsoId=O14593-1; Sequence=Displayed; Name=2; Synonyms=RFX-B-delta5; IsoId=O14593-2; Sequence=VSP_000283, VSP_000284, VSP_054618; Name=3; IsoId=O14593-3; Sequence=VSP_000284; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z205}. Nucleus {ECO:0000250|UniProtKB:Q9Z205}.


uniprotID: P48378
geneSymbol: RFX2
name: DNA-binding protein RFX2 (Regulatory factor X 2)
length: 723
go: ENSG00000087903;
snps: rs2288846 rs748493309 rs17852566
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; acrosome assembly [GO:0001675]; cellular response to leukemia inhibitory factor [GO:1990830]; cilium assembly [GO:0060271]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; spermatid development [GO:0007286]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48378-1; Sequence=Displayed; Name=2; IsoId=P48378-2; Sequence=VSP_037811; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B2GV50, ECO:0000255|PROSITE-ProRule:PRU00858}. Cytoplasm {ECO:0000250|UniProtKB:B2GV50}. Note=Mainly expressed in the nucleus and at lower level in cytoplasm. {ECO:0000250|UniProtKB:B2GV50}.


uniprotID: A5PLK6
geneSymbol: RGSL1
reactome: R-HSA-416476;R-HSA-418594;R-HSA-418597;
name: Regulator of G-protein signaling protein-like
length: 1076
go: ENSG00000121446;
opentargets: integral component of membrane [GO:0016021]
snps: rs12083859 rs647224
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=A5PLK6-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=A5PLK6-2; Sequence=VSP_035348; Note=No experimental confirmation available.; Name=3; IsoId=A5PLK6-3; Sequence=VSP_035347; Name=4; IsoId=A5PLK6-4; Sequence=VSP_035347, VSP_035354; Name=5; IsoId=A5PLK6-5; Sequence=VSP_035348, VSP_035352, VSP_035353; Note=No experimental confirmation available.; Name=6; IsoId=A5PLK6-6; Sequence=VSP_035349, VSP_035350, VSP_035351; 


uniprotID: Q6NTF9
geneSymbol: RHBDD2
name: Rhomboid domain-containing protein 2
length: 364
go: ENSG00000005486;
snps: rs11547498
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; serine-type endopeptidase activity [GO:0004252]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6NTF9-1; Sequence=Displayed; Name=2; IsoId=Q6NTF9-2; Sequence=VSP_055407; Name=3; IsoId=Q6NTF9-3; Sequence=VSP_055608; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q7Z5H3
geneSymbol: ARHGAP22
reactome: R-HSA-194840;
name: Rho GTPase-activating protein 22 (Rho-type GTPase-activating protein 22)
length: 698
go: ENSG00000128805;
snps: rs1867586 rs3747853
sequence:

opentargets:
cytosol [GO:0005829]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; regulation of postsynapse organization [GO:0099175]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q7Z5H3-1; Sequence=Displayed; Name=2; IsoId=Q7Z5H3-2; Sequence=VSP_023705; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z5H3-3; Sequence=VSP_023704; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z5H3-4; Sequence=VSP_023703; Note=No experimental confirmation available.; Name=5; IsoId=Q7Z5H3-5; Sequence=VSP_053502; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.


uniprotID: Q96D21
geneSymbol: RASD2
name: GTP-binding protein Rhes (Ras homolog enriched in striatum) (Tumor endothelial marker 2)
length: 266
go: ENSG00000100302;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
sequence:

opentargets:
plasma membrane [GO:0005886]; G-protein beta-subunit binding [GO:0031681]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol 3-kinase binding [GO:0043548]; ubiquitin conjugating enzyme binding [GO:0031624]; locomotory behavior [GO:0007626]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein sumoylation [GO:0033235]; regulation of cAMP-mediated signaling [GO:0043949]; signal transduction [GO:0007165]; synaptic transmission, dopaminergic [GO:0001963]


uniprotID: P18577
geneSymbol: RHCE
length: 417
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Blood group Rh(CE) polypeptide (Rh polypeptide 1) (RhPI) (Rh30A) (RhIXB) (Rhesus C/E antigens) (CD antigen CD240CE)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; ammonium transmembrane transporter activity [GO:0008519]; ammonium transmembrane transport [GO:0072488]

snps:
rs138268848 rs181860403 rs1053344 rs676785 rs1053346 rs1053347 rs1053350 rs1053354 rs609320 rs144163296 rs1053361 rs1132763 rs1132764 rs1053366 rs1053367 rs1053370 rs1053371 rs1053372 rs1053373 rs630612 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=14;  Name=RHI; IsoId=P18577-1; Sequence=Displayed; Name=RHIV; Synonyms=1e; IsoId=P18577-2; Sequence=VSP_005703, VSP_005704; Name=RHVI; Synonyms=7c; IsoId=P18577-3; Sequence=VSP_005702, VSP_005705; Name=RHVIII; IsoId=P18577-4; Sequence=VSP_005701; Name=1c; IsoId=P18577-5; Sequence=VSP_005705; Name=1d; IsoId=P18577-6; Sequence=VSP_037514; Name=1h; IsoId=P18577-7; Sequence=VSP_037513; Name=2e; IsoId=P18577-8; Sequence=VSP_037510, VSP_037512; Name=4g; Synonyms=RhPI-Beta; IsoId=P18577-9; Sequence=VSP_037509; Name=7a; IsoId=P18577-10; Sequence=VSP_005702; Name=8a; IsoId=P18577-11; Sequence=VSP_037506, VSP_037511; Name=8e; IsoId=P18577-12; Sequence=VSP_037507, VSP_037508; Name=8h; IsoId=P18577-13; Sequence=VSP_037505; Name=RhPI-Alpha; IsoId=P18577-14; Sequence=VSP_038405, VSP_038406; 


uniprotID: Q9NRY4
geneSymbol: ARHGAP35
reactome: R-HSA-194840;R-HSA-416550;R-HSA-8849471;
pdb: 2K85;3C5H;3FK2;
length: 1499
go: ENSG00000160007;
name:
Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; phospholipid binding [GO:0005543]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor activity [GO:0003714]; axon guidance [GO:0007411]; axonal fasciculation [GO:0007413]; camera-type eye development [GO:0043010]; cell migration [GO:0016477]; cellular response to extracellular stimulus [GO:0031668]; central nervous system neuron axonogenesis [GO:0021955]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; forebrain development [GO:0030900]; mammary gland development [GO:0030879]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of vascular permeability [GO:0043116]; neural tube closure [GO:0001843]; neuron projection guidance [GO:0097485]; positive regulation of cilium assembly [GO:0045724]; positive regulation of neuron projection development [GO:0010976]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; transcription, DNA-templated [GO:0006351]; wound healing, spreading of cells [GO:0044319]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q91YM2}. Cytoplasm {ECO:0000250|UniProtKB:Q91YM2}. Nucleus {ECO:0000305|PubMed:1894621}. Cell membrane {ECO:0000250|UniProtKB:Q91YM2}. Note=In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin. {ECO:0000250|UniProtKB:Q91YM2}.


uniprotID: Q9NV58
geneSymbol: RNF19A
reactome: R-HSA-983168;
length: 838
go: ENSG00000034677;
snps: rs9642785
name:
E3 ubiquitin-protein ligase RNF19A (EC 2.3.2.31) (Double ring-finger protein) (Dorfin) (RING finger protein 19A) (p38)

sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; integral component of membrane [GO:0016021]; postsynapse [GO:0098794]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; transcription factor binding [GO:0008134]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; microtubule cytoskeleton organization [GO:0000226]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; regulation of protein catabolic process at postsynapse, modulating synaptic transmission [GO:0099576]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NV58-1; Sequence=Displayed; Name=2; IsoId=Q9NV58-2; Sequence=VSP_021010, VSP_021011; Note=No experimental confirmation available.; Name=3; IsoId=Q9NV58-3; Sequence=VSP_028631; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787}. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.


uniprotID: Q495C1
geneSymbol: RNF212
length: 297
go: ENSG00000178222;
snps: rs17728127
name:
Probable E3 SUMO-protein ligase RNF212 (EC 2.3.2.-) (Probable E3 SUMO-protein transferase RNF212) (RING finger protein 212)

sequence:

opentargets:
synaptonemal complex [GO:0000795]; metal ion binding [GO:0046872]; SUMO transferase activity [GO:0019789]; chiasma assembly [GO:0051026]; meiotic gene conversion [GO:0006311]; protein sumoylation [GO:0016925]; reciprocal meiotic recombination [GO:0007131]; synapsis [GO:0007129]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q495C1-1; Sequence=Displayed; Name=2; IsoId=Q495C1-2; Sequence=VSP_022840, VSP_022841; Note=No experimental confirmation available.; Name=3; IsoId=Q495C1-3; Sequence=VSP_022843; Note=No experimental confirmation available.; Name=4; IsoId=Q495C1-4; Sequence=VSP_022839; Note=No experimental confirmation available. {ECO:0000305}; Name=5; IsoId=Q495C1-5; Sequence=VSP_022842, VSP_022844; Note=No experimental confirmation available.; Name=6; IsoId=Q495C1-6; Sequence=VSP_046301; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}.


uniprotID: Q63HN8
geneSymbol: RNF213
reactome: R-HSA-983168;
length: 5207
go: ENSG00000173821;
snps: rs138516230 rs61740658 rs148731719 rs145282452 rs138130613
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21799892}.
name:
E3 ubiquitin-protein ligase RNF213 (EC 2.3.2.27) (EC 3.6.4.-) (ALK lymphoma oligomerization partner on chromosome 17) (Mysterin) (RING finger protein 213) (RING-type E3 ubiquitin transferase RNF213)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; ATPase activity [GO:0016887]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; angiogenesis [GO:0001525]; negative regulation of non-canonical Wnt signaling pathway [GO:2000051]; protein autoubiquitination [GO:0051865]; protein homooligomerization [GO:0051260]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; sprouting angiogenesis [GO:0002040]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q63HN8-3; Sequence=Displayed; Note=Major isoform detected in all tissues examined.; Name=2; IsoId=Q63HN8-4; Sequence=VSP_042417; Note=Minor isoform with restricted expression. Gene prediction based on partial EST data.; Name=3; IsoId=Q63HN8-5; Sequence=VSP_042418, VSP_042419; Name=4; IsoId=Q63HN8-6; Sequence=VSP_042416, VSP_042420; Note=No experimental confirmation available.; 


uniprotID: Q8ND24
geneSymbol: RNF214
name: RING finger protein 214
length: 703
go: ENSG00000167257;
opentargets: metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8ND24-1; Sequence=Displayed; Name=2; IsoId=Q8ND24-2; Sequence=VSP_054566; Note=No experimental confirmation available.; 


uniprotID: Q9Y6U7
geneSymbol: RNF215
name: RING finger protein 215
length: 377
snps: rs5749088
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; late endosome [GO:0005770]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q9NWF9
geneSymbol: RNF216
reactome: R-HSA-936440;
length: 866
go: ENSG00000011275;
snps: rs387907368
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
E3 ubiquitin-protein ligase RNF216 (EC 2.3.2.27) (RING finger protein 216) (RING-type E3 ubiquitin transferase RNF216) (Triad domain-containing protein 3) (Ubiquitin-conjugating enzyme 7-interacting protein 1) (Zinc finger protein inhibiting NF-kappa-B)

sequence:

opentargets:
cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic endocytic zone [GO:0098843]; Schaffer collateral - CA1 synapse [GO:0098685]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; apoptotic process [GO:0006915]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein catabolic process, modulating synaptic transmission [GO:0099546]; protein K48-linked ubiquitination [GO:0070936]; regulation of defense response to virus by host [GO:0050691]; regulation of interferon-beta production [GO:0032648]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TRIAD3A; IsoId=Q9NWF9-2; Sequence=Displayed; Name=2; Synonyms=TRIAD3B; IsoId=Q9NWF9-1; Sequence=VSP_012444; Name=3; Synonyms=ZIN, TRIAD3; IsoId=Q9NWF9-3; Sequence=VSP_012443; Note=4 different alternatively spliced mRNAs code for this protein isoform.; 


uniprotID: Q8TC41
geneSymbol: RNF217
reactome: R-HSA-983168;
length: 542
go: ENSG00000146373;
snps: rs475076
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
name:
Probable E3 ubiquitin-protein ligase RNF217 (EC 2.3.2.31) (IBR domain-containing protein 1) (RING finger protein 217)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TC41-1; Sequence=Displayed; Note=No experimental confirmation available. Gene prediction based on partial mRNA and EST data.; Name=2; IsoId=Q8TC41-2; Sequence=VSP_054705, VSP_054706; Note=No experimental confirmation available.; 


uniprotID: Q5W0B1
geneSymbol: RNF219
name: RING finger protein 219
length: 726
go: ENSG00000152193;
opentargets: metal ion binding [GO:0046872]
sequence:


uniprotID: Q5VTB9
geneSymbol: RNF220
reactome: R-HSA-983168;
length: 566
go: ENSG00000187147;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6PDX6}.
name:
E3 ubiquitin-protein ligase RNF220 (EC 2.3.2.27) (RING finger protein 220) (RING-type E3 ubiquitin transferase RNF220)

sequence:

opentargets:
cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5VTB9-1; Sequence=Displayed; Name=2; IsoId=Q5VTB9-3; Sequence=VSP_055437, VSP_055438; Note=No experimental confirmation available.; 


uniprotID: A6NCQ9
geneSymbol: RNF222
name: RING finger protein 222
length: 220
go: ENSG00000189051;
opentargets: integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: E7ERA6
geneSymbol: RNF223
name: RING finger protein 223
length: 249
go: ENSG00000237330;
opentargets: integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: P0DH78
geneSymbol: RNF224
name: RING finger protein 224
length: 156
go: ENSG00000233198;
opentargets: metal ion binding [GO:0046872]
sequence:
MQDAAAGGPPGLGGGGPPEERTDCIICCSAYDLSGHLPRRLYCGHTFCQACVRRLDTPAPEQRWIPCPQCRQSTPTPRGGVAMLDLDLAAFLAVKAEREPARLEPLPLTSLKGSAITRQPAGLCPALGPQPHFPQPRYCCWGCGSLCCPPLGSPEV


uniprotID: M0QZC1
geneSymbol: RNF225
name: RING finger protein 225
length: 329
go: ENSG00000269855;
opentargets: integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: A6NIN4
geneSymbol: RNF227
name: RING finger protein 227 (Long intergenic non-protein coding RNA 2581)
length: 190
go: ENSG00000179859;
opentargets: metal ion binding [GO:0046872]
sequence:
MQLLVRVPSLPERGELDCNICYRPFNLGCRAPRRLPGTARARCGHTICTACLRELAARGDGGGAAARVVRLRRVVTCPFCRAPSQLPRGGLTEMALDSDLWSRLEEKARAKCERDEAGNPAKESSDADGEAEEEGESEKGAGPRSAGWRALRRLWDRVLGPARRWRRPLPSNVLYCAEIKDIGHLTRCTL


uniprotID: Q2M238
geneSymbol: RRN3P1
name: Putative RRN3-like protein RRN3P1 (RNA polymerase I transcription factor homolog pseudogene 1)
length: 152
sequence:
MGFAEAFLEHLWKNLQDPSNPAIIRQAAGNYIGSFLARAKFISLITVKPCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLQYPQSLNFERIVMSQLNPLKICLPSVVNFFAAITKMKTCGYGWW

opentargets:
nucleus [GO:0005634]; RNA polymerase I core binding [GO:0001042]; RNA polymerase I general transcription initiation factor activity [GO:0001181]; transcription initiation from RNA polymerase I promoter [GO:0006361]


uniprotID: A6NIE6
geneSymbol: RRN3P2
name: Putative RRN3-like protein RRN3P2 (RNA polymerase I transcription factor homolog pseudogene 2)
length: 340
sequence:


uniprotID: Q05823
geneSymbol: RNASEL
reactome: R-HSA-909733;
pdb: 1WDY;4G8K;4G8L;4OAU;4OAV;
length: 741
go: ENSG00000135828;
snps: rs151296858 rs56250729 rs35553278 rs145787003 rs486907 rs627928 rs35896902
name:
2-5A-dependent ribonuclease (2-5A-dependent RNase) (EC 3.1.26.-) (Ribonuclease 4) (Ribonuclease L) (RNase L)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nuclear matrix [GO:0016363]; ATP binding [GO:0005524]; endoribonuclease activity [GO:0004521]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; defense response to virus [GO:0051607]; fat cell differentiation [GO:0045444]; mRNA processing [GO:0006397]; negative regulation of viral genome replication [GO:0045071]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; regulation of mRNA stability [GO:0043488]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; rRNA processing [GO:0006364]; type I interferon signaling pathway [GO:0060337]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q05823-1; Sequence=Displayed; Name=2; IsoId=Q05823-2; Sequence=VSP_056272, VSP_056273; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.


uniprotID: P07998
geneSymbol: RNASE1
pdb: 1DZA;1E21;1H8X;1Z7X;2E0J;2E0L;2E0M;2E0O;2K11;2Q4G;3F8G;4KXH;
length: 156
go: ENSG00000129538;
location: SUBCELLULAR LOCATION: Secreted.
name:
Ribonuclease pancreatic (EC 3.1.27.5) (HP-RNase) (RIB-1) (RNase UpI-1) (Ribonuclease 1) (RNase 1) (Ribonuclease A) (RNase A)

sequence:
MALEKSLVRLLLLVLILLVLGWVQPSLGKESRAKKFQRQHMDSDSSPSSSSTYCNQMMRRRNMTQGRCKPVNTFVHEPLVDVQNVCFQEKVTCKNGQGNCYKSNSSMHITDCRLTNGSRYPNCAYRTSPKERHIIVACEGSPYVPVHFDASVEDST

opentargets:
extracellular exosome [GO:0070062]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; ribonuclease activity [GO:0004540]; RNA phosphodiester bond hydrolysis [GO:0090501]

drug:
DB03765;DB03448;DB02363;DB03900;DB01842;DB02714;DB08596;DB02098;DB01812;DB04272;DB02987;DB01961;DB01942;DB00536;DB02325;DB00128;DB04464;DB04514;DB03726;DB03186;DB02805;DB03447;


uniprotID: P10153
geneSymbol: RNASE2
reactome: R-HSA-6798695;
pdb: 1GQV;1HI2;1HI3;1HI4;1HI5;1K2A;2BEX;2BZZ;2C01;2C02;2C05;5E13;
length: 161
go: ENSG00000169385;
drug: DB02098;DB01812;
snps: rs8012891 rs146887874
name:
Non-secretory ribonuclease (EC 3.1.27.5) (Eosinophil-derived neurotoxin) (RNase UpI-2) (Ribonuclease 2) (RNase 2) (Ribonuclease US)

sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII

opentargets:
azurophil granule lumen [GO:0035578]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; ribonuclease activity [GO:0004540]; chemotaxis [GO:0006935]; defense response to virus [GO:0051607]; neutrophil degranulation [GO:0043312]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]

location:
SUBCELLULAR LOCATION: Lysosome {ECO:0000305}. Cytoplasmic granule. Note=Matrix of eosinophil's large specific granule.


uniprotID: Q8TDE3
geneSymbol: RNASE8
reactome: R-HSA-6803157;
name: Ribonuclease 8 (RNase 8) (EC 3.1.27.-)
length: 154
go: ENSG00000173431;
snps: rs12437266
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MAPARAGCCPLLLLLLGLWVAEVLVRAKPKDMTSSQWFKTQHVQPSPQACNSAMSIINKYTERCKDLNTFLHEPFSSVAITCQTPNIACKNSCKNCHQSHGPMSLTMGELTSGKYPNCRYKEKHLNTPYIVACDPPQQGDPGYPLVPVHLDKVV

opentargets:
extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; ribonuclease activity [GO:0004540]; antifungal innate immune response [GO:0061760]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]


uniprotID: Q96L21
geneSymbol: RPL10L
pdb: 4UG0;4V6X;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L10-like (Large ribosomal subunit protein uL16-like)
length: 214
go: ENSG00000165496;
drug: DB02494;DB07374;DB08437;
sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleus [GO:0005634]; polysome [GO:0005844]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; spermatogenesis [GO:0007283]; translation [GO:0006412]


uniprotID: P40429
geneSymbol: RPL13A
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)
length: 203
go: ENSG00000142541;
drug: DB02494;DB07374;DB08437;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14567916}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; GAIT complex [GO:0097452]; large ribosomal subunit [GO:0015934]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to interferon-gamma [GO:0071346]; negative regulation of formation of translation preinitiation complex [GO:1901194]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P30050
geneSymbol: RPL12
pdb: 4V6X;5A8L;5AJ0;
name: 60S ribosomal protein L12 (Large ribosomal subunit protein uL11)
length: 165
go: ENSG00000197958;
sequence:
MPPKFDPNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGLRITVKLTIQNRQAQIEVVPSASALIIKALKEPPRDRKKQKNIKHSGNITFDEIVNIARQMRHRSLARELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECPAS

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit assembly [GO:0000027]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P30050-1; Sequence=Displayed; Name=2; IsoId=P30050-2; Sequence=VSP_034695; Note=No experimental confirmation available.; 


uniprotID: P61313
geneSymbol: RPL15
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L15 (Large ribosomal subunit protein eL15)
length: 204
go: ENSG00000174748;
drug: DB02494;DB07374;DB08437;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61313-1; Sequence=Displayed; Name=2; IsoId=P61313-2; Sequence=VSP_045144; 


