# annotation

uniprotID: Q86U86
geneSymbol: PBRM1
reactome: R-HSA-3214858;R-HSA-8939243;
name: Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)
length: 1689
go: ENSG00000163939;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.
pdb:
2KTB;3G0J;3HMF;3IU5;3IU6;3K2J;3LJW;3MB4;3TLP;4Q0N;4Q0O;4Y03;5E7D;5FH6;5FH7;5FH8;5HRV;5HRW;5HRX;5II1;5II2;5IID;

sequence:

opentargets:
nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; RSC-type complex [GO:0016586]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; ATP-dependent chromatin remodeling [GO:0043044]; chromatin remodeling [GO:0006338]; mitotic cell cycle [GO:0000278]; negative regulation of cell proliferation [GO:0008285]; nucleosome disassembly [GO:0006337]; transcription elongation from RNA polymerase II promoter [GO:0006368]

snps:
rs923060956 rs368888772 rs765525545 rs201022657 rs776146971 rs200106731 rs753344888 rs201156614 rs35102895 rs200020801 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Name=1; IsoId=Q86U86-1; Sequence=Displayed; Name=2; IsoId=Q86U86-2; Sequence=VSP_015235; Name=3; IsoId=Q86U86-3; Sequence=VSP_015231, VSP_015235; Name=4; IsoId=Q86U86-4; Sequence=VSP_015233, VSP_015234, VSP_015235; Name=5; IsoId=Q86U86-5; Sequence=VSP_015235, VSP_015236; Name=6; IsoId=Q86U86-6; Sequence=VSP_015232; Name=7; IsoId=Q86U86-7; Sequence=VSP_035499, VSP_015235, VSP_015236; Name=8; IsoId=Q86U86-8; Sequence=VSP_035499, VSP_015236; Name=9; IsoId=Q86U86-9; Sequence=VSP_015233, VSP_015235; 


uniprotID: Q96AQ6
geneSymbol: PBXIP1
length: 731
go: ENSG00000163346;
snps: rs2061690 rs2061690
name:
Pre-B-cell leukemia transcription factor-interacting protein 1 (Hematopoietic PBX-interacting protein)

sequence:

opentargets:
cytosol [GO:0005829]; microtubule [GO:0005874]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96AQ6-1; Sequence=Displayed; Name=2; IsoId=Q96AQ6-2; Sequence=VSP_028418; Name=3; IsoId=Q96AQ6-3; Sequence=VSP_028419; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. Nucleus {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403}. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).


uniprotID: Q7L5N7
geneSymbol: LPCAT2
reactome: R-HSA-1482788;
length: 544
go: ENSG00000087253;
snps: rs837550
name:
Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; integral component of membrane [GO:0016021]; lipid droplet [GO:0005811]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; membrane organization [GO:0061024]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; platelet activating factor biosynthetic process [GO:0006663]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7L5N7-1; Sequence=Displayed; Name=2; IsoId=Q7L5N7-2; Sequence=VSP_019912; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21498505}.


uniprotID: P05166
geneSymbol: PCCB
reactome: R-HSA-196780;R-HSA-3371599;R-HSA-71032;
length: 539
go: ENSG00000114054;
drug: DB00121;DB00161;
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16023992}.
name:
Propionyl-CoA carboxylase beta chain, mitochondrial (PCCase subunit beta) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit beta)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; propionyl-CoA carboxylase activity [GO:0004658]; biotin metabolic process [GO:0006768]

snps:
rs200185747 rs747053913 rs202247818 rs202247819 rs1304714042 rs879253815 rs121964960 rs746102997 rs762354873 rs374722096 rs2228310 rs121964959 rs111033542 rs121964961 rs769521436 rs775563122 rs142403318 rs186710233 rs202247822 rs202247823 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P05166-1; Sequence=Displayed; Name=2; IsoId=P05166-2; Sequence=VSP_042568; Note=No experimental confirmation available.; 


uniprotID: Q15365
geneSymbol: PCBP1
reactome: R-HSA-72163;R-HSA-72203;
pdb: 1WVN;1ZTG;3VKE;
length: 356
go: ENSG00000169564;
name:
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; cadherin binding [GO:0045296]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific single stranded DNA binding [GO:0098847]; single-stranded DNA binding [GO:0003697]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA metabolic process [GO:0016070]; viral RNA genome replication [GO:0039694]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.


uniprotID: Q9Y5I2
geneSymbol: PCDHA10
name: Protocadherin alpha-10 (PCDH-alpha-10)
length: 948
go: ENSG00000250120;
snps: rs251362 rs251364 rs630162
sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q9Y5I2-1; Sequence=Displayed; Name=2; IsoId=Q9Y5I2-2; Sequence=VSP_000690; Name=3; IsoId=Q9Y5I2-3; Sequence=VSP_000691, VSP_000692; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.


uniprotID: Q9Y5I1
geneSymbol: PCDHA11
name: Protocadherin alpha-11 (PCDH-alpha-11)
length: 949
go: ENSG00000249158;
snps: rs10071369 rs17119218
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5I1-1; Sequence=Displayed; Name=2; IsoId=Q9Y5I1-2; Sequence=VSP_000693, VSP_000694; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.


uniprotID: Q9Y5F3
geneSymbol: PCDHB1
name: Protocadherin beta-1 (PCDH-beta-1)
length: 818
go: ENSG00000171815;
snps: rs2233591 rs2233592 rs17208383 rs10476822 rs31738 rs2233595 rs246679
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.


uniprotID: P57723
geneSymbol: PCBP4
reactome: R-HSA-6804116;R-HSA-69895;
name: Poly(rC)-binding protein 4 (Alpha-CP4)
length: 403
go: ENSG00000090097;
snps: rs323872
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14612387}.
sequence:

opentargets:
cytosol [GO:0005829]; DNA binding [GO:0003677]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; regulation of mRNA stability [GO:0043488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P57723-1; Sequence=Displayed; Name=2; IsoId=P57723-2; Sequence=VSP_010016; Note=No experimental confirmation available.; 


uniprotID: Q9Y5E6
geneSymbol: PCDHB3
name: Protocadherin beta-3 (PCDH-beta-3)
length: 796
snps: rs31849 rs12515688 rs3733699
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.


uniprotID: Q9Y5E3
geneSymbol: PCDHB6
name: Protocadherin beta-6 (PCDH-beta-6)
length: 794
snps: rs3776096 rs10076554 rs246707 rs246703 rs17685621 rs17844444
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; cell-cell recognition [GO:0009988]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91XZ4}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q91XZ4}.


uniprotID: Q9UN67
geneSymbol: PCDHB10
name: Protocadherin beta-10 (PCDH-beta-10)
length: 800
go: ENSG00000120324;
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]


uniprotID: P40426
geneSymbol: PBX3
name: Pre-B-cell leukemia transcription factor 3 (Homeobox protein PBX3)
length: 434
go: ENSG00000167081;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001205]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; adult locomotory behavior [GO:0008344]; anterior compartment pattern formation [GO:0007387]; dorsal spinal cord development [GO:0021516]; neuron development [GO:0048666]; posterior compartment specification [GO:0007388]; regulation of respiratory gaseous exchange by neurological system process [GO:0002087]; respiratory gaseous exchange [GO:0007585]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=PBX3a; IsoId=P40426-1; Sequence=Displayed; Name=PBX3b; IsoId=P40426-2; Sequence=VSP_002276, VSP_002277; Name=PBX3c; IsoId=P40426-3; Sequence=VSP_002275; Name=PBX3d; IsoId=P40426-4; Sequence=VSP_002275, VSP_002276, VSP_002277; Name=5; IsoId=P40426-5; Sequence=VSP_046311; Note=No experimental confirmation available.; 


uniprotID: Q9Y5H9
geneSymbol: PCDHA2
name: Protocadherin alpha-2 (PCDH-alpha-2)
length: 948
go: ENSG00000204969;
snps: rs9686540 rs11167600 rs6858913
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of plasma membrane [GO:0005887]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y5H9-1; Sequence=Displayed; Name=2; IsoId=Q9Y5H9-2; Sequence=VSP_000673, VSP_000674; Name=3; IsoId=Q9Y5H9-3; Sequence=VSP_008040, VSP_008041; Note=No experimental confirmation available.; 


uniprotID: Q9H158
geneSymbol: PCDHAC1
name: Protocadherin alpha-C1 (PCDH-alpha-C1)
length: 963
go: ENSG00000248383;
snps: rs246074
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=Q9H158-1; Sequence=Displayed; Name=Short; IsoId=Q9H158-2; Sequence=VSP_000699, VSP_000700; 


uniprotID: Q9Y5I4
geneSymbol: PCDHAC2
name: Protocadherin alpha-C2 (PCDH-alpha-C2)
length: 1007
go: ENSG00000243232;
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=Q9Y5I4-1; Sequence=Displayed; Name=Short; IsoId=Q9Y5I4-2; Sequence=VSP_000701, VSP_000702; 


uniprotID: Q9Y5H0
geneSymbol: PCDHGA3
name: Protocadherin gamma-A3 (PCDH-gamma-A3)
length: 932
go: ENSG00000254245;
snps: rs11575947 rs11575948 rs7736541
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; endosome to lysosome transport [GO:0008333]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; lipid tube assembly involved in organelle fusion [GO:0060989]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5H0-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5H0-2; Sequence=VSP_008663, VSP_008664; 


uniprotID: Q9Y5G7
geneSymbol: PCDHGA6
name: Protocadherin gamma-A6 (PCDH-gamma-A6)
length: 932
go: ENSG00000253731;
snps: rs11575953
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5G7-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G7-2; Sequence=VSP_008669, VSP_008670; 


uniprotID: Q9Y5G6
geneSymbol: PCDHGA7
name: Protocadherin gamma-A7 (PCDH-gamma-A7)
length: 932
go: ENSG00000253537;
snps: rs2072315 rs2240698 rs17097251
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5G6-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G6-2; Sequence=VSP_008671, VSP_008672; 


uniprotID: Q9Y5G5
geneSymbol: PCDHGA8
name: Protocadherin gamma-A8 (PCDH-gamma-A8)
length: 932
go: ENSG00000253767;
snps: rs726684 rs11575958
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5G5-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G5-2; Sequence=VSP_008673, VSP_008674; 


uniprotID: O60330
geneSymbol: PCDHGA12
name: Protocadherin gamma-A12 (PCDH-gamma-A12) (Cadherin-21) (Fibroblast cadherin-3)
length: 932
go: ENSG00000253159;
sequence:

opentargets:
cell-cell junction [GO:0005911]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60330-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=O60330-2; Sequence=VSP_008682, VSP_008683; 


uniprotID: Q9Y5G3
geneSymbol: PCDHGB1
name: Protocadherin gamma-B1 (PCDH-gamma-B1)
length: 927
sequence:

opentargets:
growth cone [GO:0030426]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5G3-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5G3-2; Sequence=VSP_008684, VSP_008685; 


uniprotID: Q8NF37
geneSymbol: LPCAT1
reactome: R-HSA-1482788;R-HSA-1482925;R-HSA-1483166;R-HSA-1483191;R-HSA-6798695;
length: 534
go: ENSG00000153395;
name:
Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2) (Phosphonoformate immuno-associated protein 3)

sequence:

opentargets:
azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; lipid droplet [GO:0005811]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 1-acylglycerol-3-phosphate O-acyltransferase activity [GO:0003841]; 1-acylglycerophosphocholine O-acyltransferase activity [GO:0047184]; 1-alkenylglycerophosphocholine O-acyltransferase activity [GO:0047159]; 1-alkylglycerophosphocholine O-acetyltransferase activity [GO:0047192]; 1-alkylglycerophosphocholine O-acyltransferase activity [GO:0047191]; 2-acylglycerol-3-phosphate O-acyltransferase activity [GO:0047144]; calcium ion binding [GO:0005509]; negative regulation of phosphatidylcholine biosynthetic process [GO:2001246]; neutrophil degranulation [GO:0043312]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]; positive regulation of protein catabolic process [GO:0045732]; retina development in camera-type eye [GO:0060041]; surfactant homeostasis [GO:0043129]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Golgi apparatus membrane {ECO:0000269|PubMed:21498505}; Single-pass type II membrane protein {ECO:0000269|PubMed:21498505}. Lipid droplet {ECO:0000269|PubMed:21498505}. Note=May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with both termini exposed to the cytoplasm. {ECO:0000269|PubMed:21498505}.


uniprotID: Q9Y5F8
geneSymbol: PCDHGB7
name: Protocadherin gamma-B7 (PCDH-gamma-B7)
length: 929
go: ENSG00000254122;
snps: rs17208397
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5F8-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9Y5F8-2; Sequence=VSP_008696, VSP_008697; 


uniprotID: Q9UN70
geneSymbol: PCDHGC3
name: Protocadherin gamma-C3 (PCDH-gamma-C3) (Protocadherin-2) (Protocadherin-43) (PC-43)
length: 934
go: ENSG00000240184;
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse organization [GO:0050808]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UN70-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9UN70-2; Sequence=VSP_008698, VSP_008699; 


uniprotID: O95206
geneSymbol: PCDH8
name: Protocadherin-8 (Arcadlin)
length: 1070
go: ENSG00000136099;
snps: rs3742301 rs5030683 rs9596693 rs5030685
sequence:

opentargets:
cell junction [GO:0030054]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic membrane [GO:0099055]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; morphogenesis of embryonic epithelium [GO:0016331]; regulation of synaptic membrane adhesion [GO:0099179]; somitogenesis [GO:0001756]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95206-1; Sequence=Displayed; Name=2; IsoId=O95206-2; Sequence=VSP_008706; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane. Note=Also expressed in neuronal cell bodies. Localized to excitatory, but not with inhibitory, synapses. {ECO:0000250}.


uniprotID: Q9HC56
geneSymbol: PCDH9
pdb: 2EE0;
name: Protocadherin-9
length: 1237
go: ENSG00000184226;
sequence:

opentargets:
cell-cell contact zone [GO:0044291]; growth cone [GO:0030426]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HC56-1; Sequence=Displayed; Name=2; IsoId=Q9HC56-2; Sequence=VSP_035430; 


uniprotID: P35227
geneSymbol: PCGF2
reactome: R-HSA-3108214;R-HSA-3899300;R-HSA-4551638;R-HSA-4570464;R-HSA-4655427;R-HSA-5617472;R-HSA-8953750;
length: 344
go: ENSG00000277258;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}.
name:
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)

sequence:

opentargets:
nuclear body [GO:0016604]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; anterior/posterior pattern specification [GO:0009952]; cellular response to hydrogen peroxide [GO:0070301]; chromatin silencing [GO:0006342]; embryonic skeletal system morphogenesis [GO:0048704]; histone acetylation [GO:0016573]; histone H2A-K119 monoubiquitination [GO:0036353]; in utero embryonic development [GO:0001701]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of transcription by RNA polymerase II [GO:0000122]


uniprotID: Q9H4Z3
geneSymbol: PCIF1
pdb: 2JX8;
name: Phosphorylated CTD-interacting factor 1
length: 704
go: ENSG00000100982;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12565871}.
sequence:

opentargets:
intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of phosphatase activity [GO:0010923]


uniprotID: Q8WW12
geneSymbol: PCNP
name: PEST proteolytic signal-containing nuclear protein (PCNP) (PEST-containing nuclear protein)
length: 178
go: ENSG00000081154;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12176013}.
sequence:
MADGKAGDEKPEKSQRAGAAGGPEEEAEKPVKTKTVSSSNGGESSSRSAEKRSAEEEAADLPTKPTKISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDEDSEPEEMPPEAKMRMKNIGRDTPTSAGPNSFNKGKHGFSDNQKLWERNIKSHLGNVHDQDN

opentargets:
nuclear body [GO:0016604]; nucleus [GO:0005634]; cell cycle [GO:0007049]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8WW12-1; Sequence=Displayed; Name=2; IsoId=Q8WW12-2; Sequence=VSP_013880, VSP_013881; Note=No experimental confirmation available.; Name=3; IsoId=Q8WW12-3; Sequence=VSP_013879; 


uniprotID: P48539
geneSymbol: PCP4
pdb: 2N77;
name: Calmodulin regulator protein PCP4 (Brain-specific polypeptide PEP-19) (Purkinje cell protein 4)
sequence: MSERQGAGATNGKDKTSGENDGQKKVQEEFDIDMDAPETERAAVAIQSQFRKFQKKKAGSQS
length: 62
go: ENSG00000183036;
opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; calmodulin dependent kinase signaling pathway [GO:0099004]; positive regulation of neuron differentiation [GO:0045666]


uniprotID: Q9UHG3
geneSymbol: PCYOX1
name: Prenylcysteine oxidase 1 (EC 1.8.3.5) (Prenylcysteine lyase)
length: 505
go: ENSG00000116005;
snps: rs2706762 rs17005441 rs34041544
location: SUBCELLULAR LOCATION: Lysosome.
sequence:

opentargets:
extracellular exosome [GO:0070062]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; very-low-density lipoprotein particle [GO:0034361]; chloride-transporting ATPase activity [GO:0008555]; prenylcysteine oxidase activity [GO:0001735]; prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]; prenylcysteine metabolic process [GO:0030329]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UHG3-1; Sequence=Displayed; Name=2; IsoId=Q9UHG3-2; Sequence=VSP_056701; Note=No experimental confirmation available.; 


uniprotID: Q9BQI7
geneSymbol: PSD2
length: 771
go: ENSG00000146005;
snps: rs34880693 rs3797902 rs35714177
name:
PH and SEC7 domain-containing protein 2 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 C) (Exchange factor for ARF6 C) (Pleckstrin homology and SEC7 domain-containing protein 2)

sequence:

opentargets:
cleavage furrow [GO:0032154]; dendrite [GO:0030425]; glutamatergic synapse [GO:0098978]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; postsynapse [GO:0098794]; ruffle membrane [GO:0032587]; ARF guanyl-nucleotide exchange factor activity [GO:0005086]; phospholipid binding [GO:0005543]; regulation of ARF protein signal transduction [GO:0032012]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6P1I6}; Single-pass membrane protein {ECO:0000305}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q6P1I6}. Cleavage furrow {ECO:0000250|UniProtKB:Q6P1I6}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. In cells undergoing cytokinesis, transiently found around the ingressing cleavage furrow. Not detected at the midbody ring/Flemming body. {ECO:0000250|UniProtKB:Q6P1I6}.


uniprotID: Q8NBM8
geneSymbol: PCYOX1L
reactome: R-HSA-114608;
name: Prenylcysteine oxidase-like (EC 1.8.3.-)
length: 494
go: ENSG00000145882;
snps: rs2291814 rs35552800 rs4705336
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; prenylcysteine oxidase activity [GO:0001735]; platelet degranulation [GO:0002576]; prenylated protein catabolic process [GO:0030327]; prenylcysteine catabolic process [GO:0030328]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NBM8-1; Sequence=Displayed; Name=2; IsoId=Q8NBM8-2; Sequence=VSP_039271, VSP_039272; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q9NYI0
geneSymbol: PSD3
length: 1048
go: ENSG00000156011;
snps: rs7016219 rs7003060 rs13263453
name:
PH and SEC7 domain-containing protein 3 (Epididymis tissue protein Li 20mP) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 D) (Exchange factor for ARF6 D) (Hepatocellular carcinoma-associated antigen 67) (Pleckstrin homology and SEC7 domain-containing protein 3)

sequence:

opentargets:
cell junction [GO:0030054]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; ruffle membrane [GO:0032587]; ARF guanyl-nucleotide exchange factor activity [GO:0005086]; regulation of ARF protein signal transduction [GO:0032012]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NYI0-1; Sequence=Displayed; Name=2; IsoId=Q9NYI0-2; Sequence=VSP_023029; Name=3; IsoId=Q9NYI0-3; Sequence=VSP_029155, VSP_029156, VSP_023029; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2PFD7}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q2PFD7}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q2PFD7}. Note=In interphase associated with the plasma membrane, in particular with membrane ruffling regions. {ECO:0000250|UniProtKB:Q2PFD7}.


uniprotID: Q9Y5Y4
geneSymbol: PTGDR2
reactome: R-HSA-391908;R-HSA-418594;
length: 395
go: ENSG00000183134;
drug: DB00328;DB00605;DB04828;
snps: rs2467642
name:
Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; prostaglandin D receptor activity [GO:0004956]; prostaglandin F receptor activity [GO:0004958]; prostaglandin J receptor activity [GO:0001785]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; calcium-mediated signaling [GO:0019722]; chemotaxis [GO:0006935]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; negative regulation of male germ cell proliferation [GO:2000255]; neuropeptide signaling pathway [GO:0007218]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.


uniprotID: Q9BRP1
geneSymbol: PDCD2L
name: Programmed cell death protein 2-like
length: 358
go: ENSG00000126249;
opentargets: cytoplasm [GO:0005737]; membrane [GO:0016020]; cell cycle [GO:0007049]
sequence:


uniprotID: Q9Y233
geneSymbol: PDE10A
reactome: R-HSA-418457;R-HSA-418555;
name: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17) (EC 3.1.4.35)
length: 779
go: ENSG00000112541;
drug: DB08384;DB08387;DB08386;DB00201;DB00975;DB01113;DB08811;DB08814;
snps: rs778899140 rs875989839 rs875989841 rs875989840 rs2224252 rs2860112
location: SUBCELLULAR LOCATION: Cytoplasm. Note=Located mostly to soluble cellular fractions.
pdb:
1LRB;2OUN;2OUP;2OUQ;2OUR;2OUS;2OUU;2OUV;2OUY;2WEY;2Y0J;2ZMF;3SN7;3SNI;3SNL;3UI7;3UUO;3WI2;3WS8;3WS9;3WYK;3WYL;3WYM;4AEL;4AJD;4AJF;4AJG;4AJM;4BBX;4DDL;4DFF;4FCB;4FCD;4HEU;4HF4;4LKQ;4LLJ;4LLK;4LLP;4LLX;4LM0;4LM1;4LM2;4LM3;4LM4;4MRW;4MRZ;4MS0;4MSA;4MSC;4MSE;4MSH;4MSN;4MUW;4MVH;4P0N;4P1R;4PHW;4TPM;4TPP;4WN1;4XY2;4YQH;4YS7;4ZO5;5AXP;5AXQ;5B4K;5B4L;5C1W;5C28;5C29;5C2A;5C2E;5C2H;5DH4;5DH5;5EDE;5EDG;5EDH;5EDI;5I2R;5K9R;5UWF;5XUI;5XUJ;

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; perikaryon [GO:0043204]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; cGMP catabolic process [GO:0046069]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cGMP-mediated signaling [GO:0010754]; regulation of protein kinase A signaling [GO:0010738]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Isoforms differ in their N-terminal region.; Name=PDE10A1; IsoId=Q9Y233-1; Sequence=Displayed; Name=PDE10A2; IsoId=Q9Y233-2; Sequence=VSP_004601; 


uniprotID: Q8WUM4
geneSymbol: PDCD6IP
reactome: R-HSA-162588;R-HSA-5210891;
pdb: 2OEV;2OEW;2OEX;2OJQ;2R02;2R03;2R05;2XS1;2XS8;2ZNE;3C3O;3C3Q;3C3R;3E1R;3WUV;4JJY;5V3R;5WA1;
length: 868
go: ENSG00000170248;
snps: rs11554560 rs3792594 rs3203777 rs76608858 rs9813017 rs3183982 rs1127732
name:
Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)

sequence:

opentargets:
actomyosin [GO:0042641]; bicellular tight junction [GO:0005923]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; Flemming body [GO:0090543]; focal adhesion [GO:0005925]; immunological synapse [GO:0001772]; melanosome [GO:0042470]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; calcium-dependent protein binding [GO:0048306]; protein homodimerization activity [GO:0042803]; proteinase activated receptor binding [GO:0031871]; actomyosin contractile ring assembly [GO:0000915]; apoptotic process [GO:0006915]; bicellular tight junction assembly [GO:0070830]; maintenance of epithelial cell apical/basal polarity [GO:0045199]; midbody abscission [GO:0061952]; mitotic cytokinesis [GO:0000281]; multivesicular body assembly [GO:0036258]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; protein homooligomerization [GO:0051260]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of extracellular exosome assembly [GO:1903551]; regulation of membrane permeability [GO:0090559]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding [GO:0046755]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8WUM4-1; Sequence=Displayed; Name=2; IsoId=Q8WUM4-2; Sequence=VSP_044860; Note=No experimental confirmation available.; Name=3; IsoId=Q8WUM4-3; Sequence=VSP_057190, VSP_057191; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QZA2}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893}. Secreted, exosome {ECO:0000269|PubMed:22660413}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9WU78}. Midbody, Midbody ring {ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Colocalized with CEP55 at centrosomes of non-dividing cells. Component of the actomyosin-tight junction complex (By similarity). PDCD6IP targeting to the midbody requires the interaction with CEP55 (PubMed:18641129). {ECO:0000250|UniProtKB:Q9QZA2, ECO:0000250|UniProtKB:Q9WU78, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:18641129}.


uniprotID: Q6L8Q7
geneSymbol: PDE12
pdb: 4Z0V;4Z2B;4ZKF;
name: 2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)
length: 609
go: ENSG00000174840;
snps: rs2241988
sequence:

opentargets:
mitochondrial matrix [GO:0005759]; 3'-5'-exoribonuclease activity [GO:0000175]; exonuclease activity [GO:0004527]; metal ion binding [GO:0046872]; poly(A)-specific ribonuclease activity [GO:0004535]; cellular response to dsRNA [GO:0071359]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-gamma [GO:0071346]; mitochondrial mRNA catabolic process [GO:0000958]; mRNA processing [GO:0006397]; negative regulation of cell death [GO:0060548]; negative regulation of oxidative phosphorylation [GO:0090324]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of viral genome replication [GO:0045070]; regulation of mitochondrial mRNA stability [GO:0044528]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6L8Q7-1; Sequence=Displayed; Name=2; IsoId=Q6L8Q7-2; Sequence=VSP_032202, VSP_032203; 

location:
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21245038, ECO:0000269|PubMed:21666256, ECO:0000269|PubMed:22285541}.


uniprotID: O43924
geneSymbol: PDE6D
reactome: R-HSA-5624958;
length: 150
go: ENSG00000156973;
pdb:
1KSG;1KSH;1KSJ;3T5G;3T5I;4JHP;4JV6;4JV8;4JVB;4JVF;5E80;5E8F;5F2U;5ML2;5ML3;5ML4;5ML6;5ML8;5NAL;5TAR;5TB5;5X72;5X73;5X74;5YAV;5YAW;

name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)

sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV

opentargets:
cilium [GO:0005929]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; GTPase inhibitor activity [GO:0005095]; Rab GTPase binding [GO:0017137]; response to stimulus [GO:0050896]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22002721, ECO:0000269|PubMed:23698361, ECO:0000269|PubMed:9712853}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9712853}; Peripheral membrane protein {ECO:0000269|PubMed:9712853}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24166846}.


uniprotID: Q13946
geneSymbol: PDE7A
reactome: R-HSA-418555;
pdb: 1ZKL;3G3N;4PM0;4Y2B;
name: High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.53) (HCP1) (TM22)
length: 482
go: ENSG00000205268;
drug: DB07954;DB00201;DB00651;
snps: rs11557049
sequence:

opentargets:
cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; G protein-coupled receptor signaling pathway [GO:0007186]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=PDE7A1; IsoId=Q13946-1; Sequence=Displayed; Name=PDE7A2; IsoId=Q13946-2; Sequence=VSP_004593; Name=PDE7A3; IsoId=Q13946-3; Sequence=VSP_038645, VSP_038646; 

location:
SUBCELLULAR LOCATION: Isoform PDE7A1: Cytoplasm, cytosol. Note=PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.; SUBCELLULAR LOCATION: Isoform PDE7A2: Cytoplasm. Note=PDE7A2 (50 kDa) is located to particulate cellular fractions.


uniprotID: Q15084
geneSymbol: PDIA6
reactome: R-HSA-381038;R-HSA-381426;R-HSA-8957275;
pdb: 1X5D;3VWW;3W8J;4EF0;4GWR;
length: 440
go: ENSG00000143870;
snps: rs4807
name:
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; peptide disulfide oxidoreductase activity [GO:0015037]; protein disulfide isomerase activity [GO:0003756]; cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; IRE1-mediated unfolded protein response [GO:0036498]; post-translational protein modification [GO:0043687]; protein folding [GO:0006457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q15084-1; Sequence=Displayed; Name=2; IsoId=Q15084-2; Sequence=VSP_021803; Name=3; IsoId=Q15084-3; Sequence=VSP_054370; Note=No experimental confirmation available.; Name=4; IsoId=Q15084-4; Sequence=VSP_055173; Note=No experimental confirmation available.; Name=5; IsoId=Q15084-5; Sequence=VSP_055174; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15466936}. Cell membrane {ECO:0000269|PubMed:15466936}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.


uniprotID: P07237
geneSymbol: P4HB
pdb: 1BJX;1MEK;1X5C;2BJX;2K18;3BJ5;3UEM;4EKZ;4EL1;4JU5;
length: 508
go: ENSG00000185624;
drug: DB03615;
snps: rs786204843
reactome:
R-HSA-1650814;R-HSA-3299685;R-HSA-381426;R-HSA-5358346;R-HSA-8866423;R-HSA-8957275;R-HSA-8963888;R-HSA-9020591;R-HSA-9020933;

name:
Protein disulfide-isomerase (PDI) (EC 5.3.4.1) (Cellular thyroid hormone-binding protein) (Prolyl 4-hydroxylase subunit beta) (p55)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum chaperone complex [GO:0034663]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; procollagen-proline 4-dioxygenase complex [GO:0016222]; enzyme binding [GO:0019899]; integrin binding [GO:0005178]; peptide disulfide oxidoreductase activity [GO:0015037]; procollagen-proline 4-dioxygenase activity [GO:0004656]; protein disulfide isomerase activity [GO:0003756]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; cell redox homeostasis [GO:0045454]; cellular protein metabolic process [GO:0044267]; cellular response to hypoxia [GO:0071456]; chylomicron assembly [GO:0034378]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-23-mediated signaling pathway [GO:0038155]; peptidyl-proline hydroxylation to 4-hydroxy-L-proline [GO:0018401]; positive regulation of viral entry into host cell [GO:0046598]; post-translational protein modification [GO:0043687]; protein folding [GO:0006457]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; response to endoplasmic reticulum stress [GO:0034976]; very-low-density lipoprotein particle assembly [GO:0034379]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23475612}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:23475612}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cell membrane {ECO:0000269|PubMed:21670307}; Peripheral membrane protein {ECO:0000305}. Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces (PubMed:11181151). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:10636893). Colocalizes with MTTP in the endoplasmic reticulum (PubMed:23475612). {ECO:0000269|PubMed:10636893, ECO:0000269|PubMed:11181151, ECO:0000269|PubMed:23475612, ECO:0000305}.


uniprotID: P30101
geneSymbol: PDIA3
reactome: R-HSA-1236974;R-HSA-901042;R-HSA-983170;
pdb: 2ALB;2DMM;2H8L;3F8U;6ENY;
length: 505
go: ENSG00000167004;
snps: rs6413485
name:
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)

sequence:

opentargets:
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; melanosome [GO:0042470]; MHC class I peptide loading complex [GO:0042824]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; recycling endosome membrane [GO:0055038]; cysteine-type endopeptidase activity [GO:0004197]; disulfide oxidoreductase activity [GO:0015036]; identical protein binding [GO:0042802]; peptide disulfide oxidoreductase activity [GO:0015037]; phospholipase C activity [GO:0004629]; protein disulfide isomerase activity [GO:0003756]; RNA binding [GO:0003723]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cell redox homeostasis [GO:0045454]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; protein folding [GO:0006457]; protein folding in endoplasmic reticulum [GO:0034975]; response to endoplasmic reticulum stress [GO:0034976]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23826168}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12643545}.


uniprotID: Q15120
geneSymbol: PDK3
reactome: R-HSA-204174;R-HSA-5362517;
pdb: 1Y8N;1Y8O;1Y8P;2PNR;2Q8I;
length: 406
go: ENSG00000067992;
drug: DB03760;DB03758;
snps: rs146331370 rs397515323
location: SUBCELLULAR LOCATION: Mitochondrion matrix.
name:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; pyruvate dehydrogenase (acetyl-transferring) kinase activity [GO:0004740]; cellular response to fatty acid [GO:0071398]; cellular response to glucose stimulus [GO:0071333]; glucose metabolic process [GO:0006006]; hypoxia-inducible factor-1alpha signaling pathway [GO:0097411]; peptidyl-serine phosphorylation [GO:0018105]; peroxisome proliferator activated receptor signaling pathway [GO:0035357]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]; regulation of glucose metabolic process [GO:0010906]; regulation of reactive oxygen species metabolic process [GO:2000377]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15120-1; Sequence=Displayed; Name=2; IsoId=Q15120-2; Sequence=VSP_043365; Note=No experimental confirmation available.; 


uniprotID: O00151
geneSymbol: PDLIM1
pdb: 1X62;2PKT;
name: PDZ and LIM domain protein 1 (C-terminal LIM domain protein 1) (Elfin) (LIM domain protein CLP-36)
length: 329
go: ENSG00000107438;
snps: rs2296961
sequence:

opentargets:
cell-cell adherens junction [GO:0005913]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; transcription factor complex [GO:0005667]; Z disc [GO:0030018]; cadherin binding involved in cell-cell adhesion [GO:0098641]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; regulation of transcription, DNA-templated [GO:0006355]; response to hypoxia [GO:0001666]; response to oxidative stress [GO:0006979]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10861853, ECO:0000269|PubMed:11110697}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10861853, ECO:0000269|PubMed:11110697}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:10861853}. Note=Associates with actin stress fibers. {ECO:0000269|PubMed:11110697}.


uniprotID: Q96JY6
geneSymbol: PDLIM2
pdb: 2PA1;3PDV;
name: PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)
length: 352
go: ENSG00000120913;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; metal ion binding [GO:0046872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=Mystique 2; IsoId=Q96JY6-1; Sequence=Displayed; Name=2; IsoId=Q96JY6-2; Sequence=VSP_014058, VSP_014059; Note=No experimental confirmation available.; Name=3; Synonyms=Mystique 1; IsoId=Q96JY6-3; Sequence=VSP_014061; Name=4; Synonyms=Mystique 3; IsoId=Q96JY6-4; Sequence=VSP_014060; Name=5; IsoId=Q96JY6-5; Sequence=VSP_047113; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15659642}. Nucleus {ECO:0000269|PubMed:15659642}. Note=May be partially nuclear.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, cytoskeleton.; SUBCELLULAR LOCATION: Isoform 3: Nucleus.


uniprotID: Q8NCN5
geneSymbol: PDPR
reactome: R-HSA-204174;
name: Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)
length: 879
go: ENSG00000090857;
snps: rs2549532
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; oxidoreductase activity [GO:0016491]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NCN5-1; Sequence=Displayed; Name=2; IsoId=Q8NCN5-2; Sequence=VSP_056077; Note=No experimental confirmation available.; 


uniprotID: Q9NR12
geneSymbol: PDLIM7
reactome: R-HSA-8853659;
pdb: 2Q3G;
name: PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)
length: 457
go: ENSG00000196923;
snps: rs2306764
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cell-cell adherens junction [GO:0005913]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; ruffle [GO:0001726]; stress fiber [GO:0001725]; metal ion binding [GO:0046872]; actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; ossification [GO:0001503]; positive regulation of osteoblast differentiation [GO:0045669]; receptor-mediated endocytosis [GO:0006898]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=LMP-1; IsoId=Q9NR12-1; Sequence=Displayed; Name=2; Synonyms=LMP-2; IsoId=Q9NR12-2; Sequence=VSP_016509; Note=Did not induce bone induction.; Name=3; Synonyms=LMP-3; IsoId=Q9NR12-3; Sequence=VSP_016510, VSP_016513; Note=Same activity as isoform 1 in bone nodule induction.; Name=4; IsoId=Q9NR12-4; Sequence=VSP_016511, VSP_016516; Note=No experimental confirmation available.; Name=5; IsoId=Q9NR12-5; Sequence=VSP_016514; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=6; IsoId=Q9NR12-6; Sequence=VSP_016512, VSP_016515; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). {ECO:0000250}.


uniprotID: Q9P0J1
geneSymbol: PDP1
reactome: R-HSA-204174;
length: 537
go: ENSG00000164951;
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
name:
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; [pyruvate dehydrogenase (lipoamide)] phosphatase activity [GO:0004741]; metal ion binding [GO:0046872]; protein serine/threonine phosphatase activity [GO:0004722]; peptidyl-threonine dephosphorylation [GO:0035970]; regulation of acetyl-CoA biosynthetic process from pyruvate [GO:0010510]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P0J1-1; Sequence=Displayed; Name=2; IsoId=Q9P0J1-2; Sequence=VSP_046869; Note=No experimental confirmation available.; 


uniprotID: Q9BRX5
geneSymbol: GINS3
reactome: R-HSA-176974;
pdb: 2E9X;2EHO;2Q9Q;
name: DNA replication complex GINS protein PSF3 (GINS complex subunit 3)
length: 216
go: ENSG00000181938;
opentargets: nucleoplasm [GO:0005654]; DNA strand elongation involved in DNA replication [GO:0006271]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BRX5-1; Sequence=Displayed; Name=2; IsoId=Q9BRX5-2; Sequence=VSP_032737; Name=3; IsoId=Q9BRX5-3; Sequence=VSP_046694; Note=Gene prediction based on EST data.; 


uniprotID: Q9UQ72
geneSymbol: PSG11
reactome: R-HSA-202733;
length: 335
go: ENSG00000243130;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]
snps: rs2471952 rs1058085 rs10414166 rs10412348
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 11 (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific beta-1-glycoprotein 13) (PS-beta-G-13) (PSBG-13) (Pregnancy-specific glycoprotein 13)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UQ72-1; Sequence=Displayed; Name=2; IsoId=Q9UQ72-2; Sequence=VSP_007876; 


uniprotID: Q00887
geneSymbol: PSG9
reactome: R-HSA-202733;
length: 426
go: ENSG00000183668;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]
snps: rs8101191 rs1058085 rs1135905 rs2074923 rs2072285
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 9 (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9) (PS34) (Pregnancy-specific beta-1 glycoprotein B) (PS-beta-B) (Pregnancy-specific beta-1-glycoprotein 11) (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific glycoprotein 7) (PSG7)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q00887-1; Sequence=Displayed; Name=2; IsoId=Q00887-2; Sequence=VSP_055602, VSP_055603; 


uniprotID: Q6P996
geneSymbol: PDXDC1
name: Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)
length: 788
go: ENSG00000179889;
drug: DB00114;
snps: rs4985162
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; cadherin binding [GO:0045296]; carboxy-lyase activity [GO:0016831]; pyridoxal phosphate binding [GO:0030170]; sphinganine-1-phosphate aldolase activity [GO:0008117]; ameboidal-type cell migration [GO:0001667]; carboxylic acid metabolic process [GO:0019752]; sphingolipid catabolic process [GO:0030149]; sphingolipid metabolic process [GO:0006665]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q6P996-1; Sequence=Displayed; Name=2; IsoId=Q6P996-2; Sequence=VSP_027341, VSP_027342, VSP_027343; Name=3; IsoId=Q6P996-3; Sequence=VSP_055731, VSP_055733; Name=4; IsoId=Q6P996-4; Sequence=VSP_055732, VSP_055734; Name=5; IsoId=Q6P996-5; Sequence=VSP_055734; 


uniprotID: Q16401
geneSymbol: PSMD5
length: 504
go: ENSG00000095261;
snps: rs2297575 rs17282618
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

name:
26S proteasome non-ATPase regulatory subunit 5 (26S protease subunit S5 basic) (26S proteasome subunit S5B)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; post-translational protein modification [GO:0043687]; proteasome regulatory particle assembly [GO:0070682]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q16401-1; Sequence=Displayed; Name=2; IsoId=Q16401-2; Sequence=VSP_045176; 


uniprotID: Q86UW1
geneSymbol: SLC51A
name: Organic solute transporter subunit alpha (OST-alpha) (Solute carrier family 51 subunit alpha)
length: 340
go: ENSG00000163959;
drug: DB00286;DB00390;DB00917;DB04348;
snps: rs939885
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782]

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250}.


uniprotID: Q86UW2
geneSymbol: SLC51B
name: Organic solute transporter subunit beta (OST-beta) (Solute carrier family 51 subunit beta)
length: 128
go: ENSG00000186198;
drug: DB00286;DB00390;DB00917;DB04348;
sequence:
MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFLPDVPETES

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; bile acid transmembrane transporter activity [GO:0015125]; protein heterodimerization activity [GO:0046982]; bile acid and bile salt transport [GO:0015721]; bile acid secretion [GO:0032782]; positive regulation of protein exit from endoplasmic reticulum [GO:0070863]; positive regulation of protein glycosylation [GO:0060050]; positive regulation of protein targeting to membrane [GO:0090314]; regulation of protein stability [GO:0031647]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}; Single-pass membrane protein {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.


uniprotID: P04637
geneSymbol: TP53
name: Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
length: 393
go: ENSG00000141510;
drug: DB08363;DB00945;DB05404;
reactome:
R-HSA-111448;R-HSA-139915;R-HSA-1912408;R-HSA-2559580;R-HSA-2559584;R-HSA-2559585;R-HSA-2559586;R-HSA-3232118;R-HSA-349425;R-HSA-390471;R-HSA-5628897;R-HSA-5689880;R-HSA-5689896;R-HSA-5693565;R-HSA-6785807;R-HSA-6796648;R-HSA-6803204;R-HSA-6803205;R-HSA-6803207;R-HSA-6803211;R-HSA-6804114;R-HSA-6804115;R-HSA-6804116;R-HSA-6804754;R-HSA-6804756;R-HSA-6804757;R-HSA-6804758;R-HSA-6804759;R-HSA-6804760;R-HSA-6811555;R-HSA-69473;R-HSA-69481;R-HSA-69541;R-HSA-69895;R-HSA-8852276;R-HSA-8941855;R-HSA-8943724;R-HSA-983231;

pdb:
1A1U;1AIE;1C26;1DT7;1GZH;1H26;1HS5;1JSP;1KZY;1MA3;1OLG;1OLH;1PES;1PET;1SAE;1SAF;1SAK;1SAL;1TSR;1TUP;1UOL;1XQH;1YC5;1YCQ;1YCR;1YCS;2AC0;2ADY;2AHI;2ATA;2B3G;2BIM;2BIN;2BIO;2BIP;2BIQ;2F1X;2FEJ;2FOJ;2FOO;2GS0;2H1L;2H2D;2H2F;2H4F;2H4H;2H4J;2H59;2J0Z;2J10;2J11;2J1W;2J1X;2J1Y;2J1Z;2J20;2J21;2K8F;2L14;2LY4;2MEJ;2MWO;2MWP;2MWY;2MZD;2OCJ;2PCX;2RUK;2VUK;2WGX;2X0U;2X0V;2X0W;2XWR;2YBG;2YDR;2Z5S;2Z5T;3D05;3D06;3D07;3D08;3D09;3D0A;3DAB;3DAC;3IGK;3IGL;3KMD;3KZ8;3LW1;3OQ5;3PDH;3Q01;3Q05;3Q06;3SAK;3TG5;3TS8;3ZME;4AGL;4AGM;4AGN;4AGO;4AGP;4AGQ;4BUZ;4BV2;4HFZ;4HJE;4IBQ;4IBS;4IBT;4IBU;4IBV;4IBW;4IBY;4IBZ;4IJT;4KVP;4LO9;4LOE;4LOF;4MZI;4MZR;4QO1;4RP6;4RP7;4X34;4XR8;4ZZJ;5A7B;5AB9;5ABA;5AOI;5AOJ;5AOK;5AOL;5AOM;5BUA;5ECG;5G4M;5G4N;5G4O;5HOU;5HP0;5HPD;5LAP;5LGY;5MCT;5MCU;5MCV;5MCW;5MF7;5MG7;5MHC;5MOC;5O1A;5O1B;5O1C;5O1D;5O1E;5O1F;5O1G;5O1H;5O1I;5OL0;5UN8;6FF9;6FJ5;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; intracellular [GO:0005622]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nuclear chromatin [GO:0000790]; nuclear matrix [GO:0016363]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; chaperone binding [GO:0051087]; chromatin binding [GO:0003682]; copper ion binding [GO:0005507]; core promoter sequence-specific DNA binding [GO:0001046]; disordered domain specific binding [GO:0097718]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; p53 binding [GO:0002039]; promoter-specific chromatin binding [GO:1990841]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; protein N-terminus binding [GO:0047485]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase binding [GO:0019903]; protein self-association [GO:0043621]; receptor tyrosine kinase binding [GO:0030971]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; TFIID-class transcription factor complex binding [GO:0001094]; transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly [GO:0001074]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; autophagy [GO:0006914]; base-excision repair [GO:0006284]; cell aging [GO:0007569]; cell cycle arrest [GO:0007050]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular protein localization [GO:0034613]; cellular response to actinomycin D [GO:0072717]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to drug [GO:0035690]; cellular response to gamma radiation [GO:0071480]; cellular response to glucose starvation [GO:0042149]; cellular response to hypoxia [GO:0071456]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; chromatin assembly [GO:0031497]; circadian behavior [GO:0048512]; cytokine-mediated signaling pathway [GO:0019221]; determination of adult lifespan [GO:0008340]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; DNA strand renaturation [GO:0000733]; entrainment of circadian clock by photoperiod [GO:0043153]; ER overload response [GO:0006983]; intrinsic apoptotic signaling pathway [GO:0097193]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint [GO:0031571]; mRNA transcription [GO:0009299]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of helicase activity [GO:0051097]; negative regulation of telomerase activity [GO:0051974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleotide-excision repair [GO:0006289]; oligodendrocyte apoptotic process [GO:0097252]; oxidative stress-induced premature senescence [GO:0090403]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903800]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [GO:1900740]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [GO:0045899]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription, DNA-templated [GO:0045893]; protein deubiquitination [GO:0016579]; protein homotetramerization [GO:0051289]; protein localization [GO:0008104]; protein tetramerization [GO:0051262]; protein-containing complex assembly [GO:0065003]; Ras protein signal transduction [GO:0007265]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; replicative senescence [GO:0090399]; response to antibiotic [GO:0046677]; response to gamma radiation [GO:0010332]; signal transduction by p53 class mediator [GO:0072331]; viral process [GO:0016032]

snps:
rs587782646 rs535274413 rs201382018 rs201382018 rs201753350 rs121912661 rs587781866 rs1353016807 rs1060501190 rs876659630 rs1800371 rs587780728 rs587780728 rs1237722021 rs1460793472 rs876658902 rs372201428 rs1060501210 rs756233241 rs756233241 rs730882014 rs1042522 rs1042522 rs587782423 rs1060501204 rs534447939 rs201717599 rs201717599 rs730881994 rs1210700121 rs1245723119 rs878854069 rs786202717 rs587781504 rs1060501195 rs587782447 rs368771578 rs587782461 rs1064796722 rs587781371 rs11540654 rs11540654 rs11540654 rs587781371 rs1057519997 rs1423803759 rs587781642 rs755238756 rs1064794141 rs121912658 rs730881997 rs730881997 rs786201057 rs786201057 rs1057520003 rs886039483 rs730881999 rs730881999 rs1438095083 rs137852792 rs863224683 rs1131691013 rs863224683 rs1131691037 rs769270327 rs587782160 rs747342068 rs1057519996 rs866775781 rs1064795139 rs28934873 rs1057280220 rs780442292 rs267605077 rs1057519975 rs1057519976 rs587781991 rs758781593 rs28934875 rs750600586 rs1212996409 rs786202561 rs1057519978 rs1057519977 rs587781288 rs779196500 rs587782620 rs587782620 rs786203071 rs587782197 rs786203064 rs1453167097 rs1046611742 rs1131691007 rs1057520000 rs28934874 rs28934874 rs587782705 rs767328513 rs1064795860 rs762846821 rs137852789 rs772683278 rs786202752 rs563378859 rs371524413 rs1131691023 rs121912654 rs121912654 rs587780068 rs587782144 rs587782144 rs730882022 rs730882000 rs772354334 rs1064795691 rs193920817 rs587780069 rs148924904 rs786203436 rs879254249 rs1131691034 rs867114783 rs587780729 rs779000871 rs587781845 rs1131691043 rs1131691021 rs1057519747 rs876660754 rs864622115 rs1064796681 rs138729528 rs138729528 rs28934578 rs28934578 rs967461896 rs1057519980 rs786202962 rs751477326 rs147002414 rs1064795203 rs1057519991 rs587780070 rs879253911 rs587782596 rs397514495 rs397514495 rs587782596 rs1060501209 rs72661117 rs150607408 rs375275361 rs1060501206 rs776167460 rs1199893366 rs121912665 rs876660825 rs876660254 rs587778718 rs868590738 rs730882002 rs786201838 rs786201838 rs876658468 rs587780071 rs1057519998 rs942158624 rs760043106 rs397516435 rs483352697 rs483352697 rs483352697 rs786204041 rs786204041 rs730882024 rs587780072 rs587780072 rs587778719 rs587778719 rs730882003 rs1260903787 rs1057520008 rs1057520007 rs923100890 rs1464727668 rs1060501200 rs1060501198 rs1064795766 rs587778720 rs587778720 rs587781386 rs1057519992 rs886039484 rs1057520001 rs587782177 rs1057520004 rs730882025 rs35163653 rs878854072 rs1420675064 rs879253894 rs121912666 rs530941076 rs121912666 rs786201592 rs146340390 rs1060501203 rs138983188 rs138983188 rs746504075 rs970212462 rs1064794312 rs1064793603 rs587781589 rs879254233 rs587780073 rs864622237 rs144340710 rs786204145 rs587782289 rs587782289 rs730882026 rs587782664 rs765848205 rs730882004 rs1057519981 rs193920789 rs730882005 rs876660807 rs1057522275 rs1057519999 rs28934573 rs28934573 rs1057520002 rs1057519982 rs121912655 rs121912655 rs786203117 rs730882006 rs985033810 rs1057517983 rs1057519989 rs121912656 rs28934575 rs121912656 rs28934575 rs121912656 rs1019340046 rs483352695 rs587780074 rs483352695 rs1452189221 rs786201762 rs11540652 rs11540652 rs11540652 rs121912651 rs587782329 rs28934571 rs587782082 rs1064794311 rs730882007 rs730882027 rs121912653 rs1330865474 rs746601313 rs1057519995 rs876659675 rs28934577 rs28934577 rs1060501201 rs121912652 rs745425759 rs876658916 rs200579969 rs200579969 rs1131691025 rs72661119 rs879253942 rs193920774 rs1057519990 rs193920774 rs587780075 rs55832599 rs1057519986 rs1057519988 rs1057519987 rs1060501191 rs876660333 rs121912657 rs121912657 rs121913343 rs28934576 rs28934576 rs28934576 rs121913343 rs1057520006 rs1057520005 rs1057519983 rs863224451 rs786202082 rs786202082 rs1131691029 rs763098116 rs1064795369 rs763098116 rs17849781 rs876659802 rs1064793881 rs121912660 rs121912660 rs1057519984 rs587781525 rs764146326 rs587781525 rs764146326 rs28934574 rs730882008 rs730882008 rs28934574 rs149633775 rs371409680 rs149633775 rs863224685 rs1204379654 rs112431538 rs121912667 rs786201059 rs1057519985 rs748891343 rs587782006 rs770374782 rs55819519 rs372613518 rs781490101 rs121912663 rs587780076 rs587780076 rs1305324490 rs751713111 rs1131691006 rs483352696 rs672601296 rs876659477 rs201744589 rs909643864 rs1060501202 rs863224686 rs876658714 rs587782654 rs1048095040 rs56184981 rs56184981 rs145151284 rs1367492395 rs751440465 rs772773208 rs1060501199 rs764735889 rs1159579789 rs1432281680 rs121912659 rs969930693 rs11575996 rs1064795056 rs771939956 rs587782529 rs121912664 rs121912664 rs121912664 rs150293825 rs17882252 rs17882252 rs375338359 rs375338359 rs121912662 rs755394212 rs752142489 rs587782237 rs35993958 rs35993958 rs876660285 rs267605075 rs17881470 rs863224682 rs587783064 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=9;  Name=1; Synonyms=p53, p53alpha; IsoId=P04637-1; Sequence=Displayed; Name=2; Synonyms=I9RET, p53beta; IsoId=P04637-2; Sequence=VSP_006535, VSP_006536; Note=Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=p53gamma; IsoId=P04637-3; Sequence=VSP_040560, VSP_040561; Note=Expressed in quiescent lymphocytes. Seems to be non-functional. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=Del40-p53, Del40-p53alpha, p47; IsoId=P04637-4; Sequence=VSP_040832; Name=5; Synonyms=Del40-p53beta; IsoId=P04637-5; Sequence=VSP_040832, VSP_006535, VSP_006536; Name=6; Synonyms=Del40-p53gamma; IsoId=P04637-6; Sequence=VSP_040832, VSP_040560, VSP_040561; Name=7; Synonyms=Del133-p53, Del133-p53alpha; IsoId=P04637-7; Sequence=VSP_040833; Note=Produced by alternative promoter usage.; Name=8; Synonyms=Del133-p53beta; IsoId=P04637-8; Sequence=VSP_040833, VSP_006535, VSP_006536; Note=Produced by alternative promoter usage and alternative splicing.; Name=9; Synonyms=Del133-p53gamma; IsoId=P04637-9; Sequence=VSP_040833, VSP_040560, VSP_040561; Note=Produced by alternative promoter usage and alternative splicing.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Endoplasmic reticulum. Mitochondrion matrix. Note=Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2. Translocates to mitochondria upon oxidative stress. Translocates to mitochondria in response to mitomycin C treatment (PubMed:27323408). {ECO:0000269|PubMed:27323408}.; SUBCELLULAR LOCATION: Isoform 1: Nucleus. Cytoplasm. Note=Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4.; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Nucleus. Cytoplasm. Note=Localized in the nucleus in most cells but found in the cytoplasm in some cells.; SUBCELLULAR LOCATION: Isoform 4: Nucleus. Cytoplasm. Note=Predominantly nuclear but translocates to the cytoplasm following cell stress.; SUBCELLULAR LOCATION: Isoform 7: Nucleus. Cytoplasm. Note=Localized mainly in the nucleus with minor staining in the cytoplasm.; SUBCELLULAR LOCATION: Isoform 8: Nucleus. Cytoplasm. Note=Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli.; SUBCELLULAR LOCATION: Isoform 9: Cytoplasm.


uniprotID: P28070
geneSymbol: PSMB4
length: 264
go: ENSG00000159377;
snps: rs1804241 rs4603
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

pdb:
4R3O;4R67;5A0Q;5GJQ;5GJR;5L4G;5LE5;5LEX;5LEY;5LEZ;5LF0;5LF1;5LF3;5LF4;5LF6;5LF7;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFO;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;6AVO;

name:
Proteasome subunit beta type-4 (EC 3.4.25.1) (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; proteasome core complex [GO:0005839]; proteasome core complex, beta-subunit complex [GO:0019774]; endopeptidase activity [GO:0004175]; lipopolysaccharide binding [GO:0001530]; threonine-type endopeptidase activity [GO:0004298]; negative regulation of inflammatory response to antigenic stimulus [GO:0002862]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345}. Nucleus {ECO:0000269|PubMed:12181345}.


uniprotID: P0C869
geneSymbol: PLA2G4B
reactome: R-HSA-1482788;R-HSA-1482801;R-HSA-1482839;R-HSA-1482925;R-HSA-1483115;R-HSA-1483166;R-HSA-381038;
name: Cytosolic phospholipase A2 beta (cPLA2-beta) (EC 3.1.1.4) (Phospholipase A2 group IVB)
length: 781
go: ENSG00000168970;ENSG00000243708;
snps: rs3816533 rs2290552 rs34807597 rs36126315
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extracellular region [GO:0005576]; mitochondrial inner membrane [GO:0005743]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; calcium-dependent phospholipid binding [GO:0005544]; lysophospholipase activity [GO:0004622]; phospholipase A1 activity [GO:0008970]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; arachidonic acid metabolic process [GO:0019369]; calcium-mediated signaling [GO:0019722]; glycerophospholipid catabolic process [GO:0046475]; inflammatory response [GO:0006954]; IRE1-mediated unfolded protein response [GO:0036498]; parturition [GO:0007567]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P0C869-1, O95712-1; Sequence=Displayed; Name=2; Synonyms=beta2; IsoId=P0C869-7; Sequence=VSP_039387, VSP_039389, VSP_039390; Note=Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.; Name=3; Synonyms=beta3; IsoId=P0C869-8; Sequence=VSP_039387, VSP_039388; Note=Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.; Name=4; IsoId=P0C869-4, O95712-4; Sequence=VSP_019871; Note=No experimental confirmation available.; Name=5; Synonyms=Beta1; IsoId=P0C869-6; Sequence=VSP_039387; Note=Based on a naturally occurring readthrough transcript which produces a JMJD7-PLA2G4B fusion protein.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}.; SUBCELLULAR LOCATION: Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.


uniprotID: P39877
geneSymbol: PLA2G5
reactome: R-HSA-1482788;R-HSA-1482801;R-HSA-1482839;R-HSA-1482922;R-HSA-1482925;R-HSA-1483166;
pdb: 2GHN;
length: 138
go: ENSG00000127472;
snps: rs387906795 rs387906796
location: SUBCELLULAR LOCATION: Secreted.
name:
Calcium-dependent phospholipase A2 (EC 3.1.1.4) (Group V phospholipase A2) (PLA2-10) (Phosphatidylcholine 2-acylhydrolase 5)

sequence:
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS

opentargets:
cell surface [GO:0009986]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; heparin binding [GO:0008201]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; phospholipid binding [GO:0005543]; arachidonic acid secretion [GO:0050482]; leukotriene biosynthetic process [GO:0019370]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of inflammatory response [GO:0050728]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]; platelet activating factor biosynthetic process [GO:0006663]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of phospholipase activity [GO:0010518]; regulation of macrophage activation [GO:0043030]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]


uniprotID: P14555
geneSymbol: PLA2G2A
reactome: R-HSA-1482788;R-HSA-1482801;R-HSA-1482839;R-HSA-1482922;R-HSA-1482925;R-HSA-1483166;R-HSA-6803157;
pdb: 1AYP;1BBC;1DB4;1DB5;1DCY;1J1A;1KQU;1KVO;1N28;1N29;1POD;1POE;2GNY;3U8B;3U8D;3U8H;3U8I;5G3N;
length: 144
go: ENSG00000188257;
snps: rs11573162
name:
Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A)

sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; phospholipid binding [GO:0005543]; antimicrobial humoral response [GO:0019730]; arachidonic acid secretion [GO:0050482]; defense response to Gram-positive bacterium [GO:0050830]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidic acid metabolic process [GO:0046473]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of inflammatory response [GO:0050729]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]

drug:
DB04287;DB03121;DB04112;DB02936;DB03471;DB02504;DB00586;DB03784;DB01381;DB00328;DB02325;DB03017;DB02448;DB04786;

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000269|PubMed:2775276}. Secreted {ECO:0000269|PubMed:2925608, ECO:0000269|PubMed:2925633}.


uniprotID: Q9NZK7
geneSymbol: PLA2G2E
reactome: R-HSA-1482788;R-HSA-1482801;R-HSA-1482839;R-HSA-1482922;R-HSA-1482925;R-HSA-1483166;
pdb: 5WZM;5WZO;5WZS;5WZT;5WZU;5WZV;5WZW;5Y5E;
length: 142
go: ENSG00000188784;
location: SUBCELLULAR LOCATION: Secreted.
name:
Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E)

sequence:
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC

opentargets:
extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; phospholipid binding [GO:0005543]; arachidonic acid secretion [GO:0050482]; inflammatory response [GO:0006954]; lipid catabolic process [GO:0016042]; low-density lipoprotein particle remodeling [GO:0034374]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]

drug:
DB07958;DB07500;DB07950;DB06987;DB08447;DB00233;DB04077;DB02758;DB04725;DB02448;DB04743;DB03585;DB02795;


uniprotID: O15496
geneSymbol: PLA2G10
reactome: R-HSA-1482788;R-HSA-1482801;R-HSA-1482839;R-HSA-1482922;R-HSA-1482925;R-HSA-1483166;
pdb: 1LE6;1LE7;4UY1;5G3M;5OW8;5OWC;6G5J;
length: 165
go: ENSG00000069764;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9188469}.
name:
Group 10 secretory phospholipase A2 (EC 3.1.1.4) (Group X secretory phospholipase A2) (GX sPLA2) (sPLA2-X) (Phosphatidylcholine 2-acylhydrolase 10)

sequence:
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; phospholipase activity [GO:0004620]; phospholipid binding [GO:0005543]; arachidonic acid metabolic process [GO:0019369]; arachidonic acid secretion [GO:0050482]; axon guidance [GO:0007411]; cellular response to leukemia inhibitory factor [GO:1990830]; cholesterol homeostasis [GO:0042632]; lipid catabolic process [GO:0016042]; lysophospholipid transport [GO:0051977]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylserine acyl-chain remodeling [GO:0036150]; phospholipid metabolic process [GO:0006644]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of lipid storage [GO:0010884]; positive regulation of macrophage derived foam cell differentiation [GO:0010744]; positive regulation of prostaglandin secretion [GO:0032308]; regulation of macrophage activation [GO:0043030]


uniprotID: Q9NZ20
geneSymbol: PLA2G3
reactome: R-HSA-1482788;R-HSA-1482839;R-HSA-1482925;
length: 509
go: ENSG00000100078;
snps: rs2232176 rs2074734 rs2074735 rs2232180 rs2072193 rs2232183
name:
Group 3 secretory phospholipase A2 (EC 3.1.1.4) (Group III secretory phospholipase A2) (GIII sPLA2) (sPLA2-III) (Phosphatidylcholine 2-acylhydrolase 3)

sequence:

opentargets:
centriole [GO:0005814]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; mast cell granule [GO:0042629]; plasma membrane [GO:0005886]; calcium-dependent phospholipase A2 activity [GO:0047498]; metal ion binding [GO:0046872]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; acrosome assembly [GO:0001675]; arachidonic acid secretion [GO:0050482]; cilium assembly [GO:0060271]; lipid catabolic process [GO:0016042]; lipoxygenase pathway [GO:0019372]; mast cell degranulation [GO:0043303]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid metabolic process [GO:0006644]; sperm axoneme assembly [GO:0007288]

location:
SUBCELLULAR LOCATION: Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.


uniprotID: Q13093
geneSymbol: PLA2G7
reactome: R-HSA-422085;
length: 441
go: ENSG00000146070;
drug: DB05256;
snps: rs45521937 rs1805017 rs45454695 rs1805018 rs76863441 rs201256712 rs1051931
location: SUBCELLULAR LOCATION: Secreted, extracellular space.
pdb:
3D59;3D5E;3F96;3F97;3F98;3F9C;5I8P;5I9I;5JAD;5JAH;5JAL;5JAN;5JAO;5JAP;5JAR;5JAS;5JAT;5JAU;5LP1;5LYY;5LZ2;5LZ4;5LZ5;5LZ7;5LZ8;5LZ9;5YE7;5YE8;5YE9;5YEA;

name:
Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; low-density lipoprotein particle [GO:0034362]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; calcium-independent phospholipase A2 activity [GO:0047499]; hydrolase activity, acting on ester bonds [GO:0016788]; phospholipid binding [GO:0005543]; lipid catabolic process [GO:0016042]; lipid oxidation [GO:0034440]; low-density lipoprotein particle remodeling [GO:0034374]; plasma lipoprotein particle oxidation [GO:0034441]; platelet activating factor metabolic process [GO:0046469]; positive regulation of inflammatory response [GO:0050729]; positive regulation of monocyte chemotaxis [GO:0090026]


uniprotID: P0DN26
geneSymbol: PPIAL4F
name: Peptidyl-prolyl cis-trans isomerase A-like 4F (PPIase A-like 4F) (EC 5.2.1.8)
length: 164
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
sequence:
MVNSVVFFEITRDGKPLGRISIKLFADKIPKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRPNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF

opentargets:
mitochondrion [GO:0005739]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]


uniprotID: Q86YC2
geneSymbol: PALB2
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;
pdb: 2W18;3EU7;
name: Partner and localizer of BRCA2
length: 1186
go: ENSG00000083093;
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; animal organ morphogenesis [GO:0009887]; double-strand break repair via homologous recombination [GO:0000724]; embryonic organ development [GO:0048568]; inner cell mass cell proliferation [GO:0001833]; mesoderm development [GO:0007498]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; post-anal tail morphogenesis [GO:0036342]; somitogenesis [GO:0001756]

snps:
rs138789658 rs515726129 rs141047069 rs202194596 rs45594034 rs3809683 rs200620434 rs45494092 rs749461008 rs576081828 rs577969558 rs515726072 rs152451 rs45532440 rs141458731 rs45568339 rs763645981 rs45624036 rs45478192 rs786204248 rs45551636 rs746872839 rs377713277 rs62625284 rs200283306 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:28319063}. Note=Colocalizes with BRCA2 and BRCA1 in nuclear foci. {ECO:0000269|PubMed:16793542, ECO:0000269|PubMed:28319063}.


uniprotID: Q8WX93
geneSymbol: PALLD
pdb: 2DM2;2DM3;
name: Palladin (SIH002) (Sarcoma antigen NY-SAR-77)
length: 1383
go: ENSG00000129116;
snps: rs7671781 rs7655494
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; axon [GO:0030424]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; Z disc [GO:0030018]; actin binding [GO:0003779]; cell-cell adhesion mediator activity [GO:0098632]; muscle alpha-actinin binding [GO:0051371]; actin cytoskeleton organization [GO:0030036]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; dendrite self-avoidance [GO:0070593]; epithelial cell morphogenesis [GO:0003382]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; keratinocyte development [GO:0003334]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Name=1; Synonyms=200-kDa; IsoId=Q8WX93-1; Sequence=Displayed; Name=2; IsoId=Q8WX93-2; Sequence=VSP_027929, VSP_027930; Name=3; Synonyms=140-kDa; IsoId=Q8WX93-3; Sequence=VSP_027927; Name=4; Synonyms=90-kDa; IsoId=Q8WX93-4; Sequence=VSP_027926; Name=5; IsoId=Q8WX93-5; Sequence=VSP_027929; Note=No experimental confirmation available.; Name=6; IsoId=Q8WX93-6; Sequence=VSP_027928; Note=No experimental confirmation available.; Name=7; IsoId=Q8WX93-7; Sequence=VSP_027925; Name=8; IsoId=Q8WX93-8; Sequence=VSP_027927, VSP_027929; Name=9; IsoId=Q8WX93-9; Sequence=VSP_027929, VSP_043794, VSP_043795; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}. Cell junction, focal adhesion {ECO:0000269|PubMed:17322171}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:16125169}. Cell projection, ruffle {ECO:0000269|PubMed:17537434}. Cell projection, podosome {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, lamellipodium {ECO:0000269|PubMed:17537434}. Cell projection, axon {ECO:0000250|UniProtKB:P0C5E3}. Cell projection, growth cone {ECO:0000250|UniProtKB:P0C5E3}. Note=Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434). Preferentially expressed in the excitatory presynaptic terminals (By similarity). {ECO:0000250|UniProtKB:P0C5E3, ECO:0000269|PubMed:11598191, ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:17322171, ECO:0000269|PubMed:17537434}.


uniprotID: P05121
geneSymbol: SERPINE1
reactome: R-HSA-114608;R-HSA-1368108;R-HSA-2173796;R-HSA-3000178;R-HSA-75205;
length: 402
go: ENSG00000106366;
drug: DB00009;DB00029;DB00055;DB05254;DB00015;DB00031;DB00197;DB00013;
snps: rs6092 rs6090 rs2227647 rs2227669 rs2227685
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2430793}.
pdb:
1A7C;1B3K;1C5G;1DB2;1DVM;1DVN;1LJ5;1OC0;3CVM;3EOX;3PB1;3Q02;3Q03;3R4L;3UT3;4AQH;4G8O;4G8R;4IC0;5BRR;9PAI;

name:
Plasminogen activator inhibitor 1 (PAI) (PAI-1) (Endothelial plasminogen activator inhibitor) (Serpin E1)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; plasma membrane [GO:0005886]; platelet alpha granule lumen [GO:0031093]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; cellular response to lipopolysaccharide [GO:0071222]; chronological cell aging [GO:0001300]; circadian rhythm [GO:0007623]; defense response to Gram-negative bacterium [GO:0050829]; dentinogenesis [GO:0097187]; extracellular matrix organization [GO:0030198]; fibrinolysis [GO:0042730]; negative regulation of blood coagulation [GO:0030195]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cell migration [GO:0030336]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of plasminogen activation [GO:0010757]; negative regulation of smooth muscle cell migration [GO:0014912]; negative regulation of smooth muscle cell-matrix adhesion [GO:2000098]; negative regulation of vascular wound healing [GO:0061044]; negative regulation of wound healing [GO:0061045]; platelet degranulation [GO:0002576]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood coagulation [GO:0030194]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of leukotriene production involved in inflammatory response [GO:0035491]; positive regulation of monocyte chemotaxis [GO:0090026]; positive regulation of odontoblast differentiation [GO:1901331]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of signaling receptor activity [GO:0010469]; replicative senescence [GO:0090399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P05121-1; Sequence=Displayed; Name=2; IsoId=P05121-2; Sequence=VSP_045493; Note=No experimental confirmation available.; 


uniprotID: Q9NP74
geneSymbol: PALMD
name: Palmdelphin (Paralemmin-like protein)
length: 551
go: ENSG00000099260;
snps: rs11802902 rs35258980 rs35317701
sequence:

opentargets:
cytoplasm [GO:0005737]; dendritic spine [GO:0043197]; membrane [GO:0016020]; regulation of cell shape [GO:0008360]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NP74-1; Sequence=Displayed; Name=2; IsoId=Q9NP74-2; Sequence=VSP_021787; Name=3; IsoId=Q9NP74-3; Sequence=VSP_021786; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11707320}. Cell projection, dendrite {ECO:0000269|PubMed:11707320}. Cell projection, dendritic spine {ECO:0000250}.


uniprotID: Q9H074
geneSymbol: PAIP1
reactome: R-HSA-429947;
pdb: 1JH4;3NTW;3RK6;
length: 479
go: ENSG00000172239;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
name:
Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; RNA binding [GO:0003723]; translation activator activity [GO:0008494]; mRNA stabilization [GO:0048255]; regulation of translational initiation [GO:0006446]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H074-1; Sequence=Displayed; Name=2; IsoId=Q9H074-2; Sequence=VSP_010005; Name=3; IsoId=Q9H074-3; Sequence=VSP_047503; Note=No experimental confirmation available. {ECO:0000244|PubMed:22223895}; 


uniprotID: Q9Y536
geneSymbol: PPIAL4A
length: 164
go: ENSG00000263353;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62937}.
name:
Peptidyl-prolyl cis-trans isomerase A-like 4A (PPIase A-like 4A) (EC 5.2.1.8) (Chromosome one-amplified sequence 2) (COAS-2) (Cyclophilin homolog overexpressed in liver cancer)

sequence:
MVNSVVFFDITVDGKPLGRISIKLFADKILKTAENFRALSTGEKGFRYKGSCFHRIIPGFMCQGGDFTRHNGTGDKSIYGEKFDDENLIRKHTGSGILSMANAGPNTNGSQFFICAAKTEWLDGKHVAFGKVKERVNIVEAMEHFGYRNSKTSKKITIADCGQF

opentargets:
extracellular exosome [GO:0070062]; mitochondrion [GO:0005739]; cyclosporin A binding [GO:0016018]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]


uniprotID: P40424
geneSymbol: PBX1
reactome: R-HSA-452723;R-HSA-5617472;R-HSA-9013508;
pdb: 1B72;1PUF;
name: Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)
length: 430
go: ENSG00000185630;
snps: rs2275558
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28270404}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription factor binding [GO:0008134]; adrenal gland development [GO:0030325]; anterior/posterior pattern specification [GO:0009952]; branching involved in ureteric bud morphogenesis [GO:0001658]; embryonic hemopoiesis [GO:0035162]; embryonic limb morphogenesis [GO:0030326]; embryonic skeletal system development [GO:0048706]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of neuron differentiation [GO:0045665]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of transcription of Notch receptor target [GO:0007221]; proximal/distal pattern formation [GO:0009954]; regulation of ossification [GO:0030278]; sex differentiation [GO:0007548]; somatic stem cell population maintenance [GO:0035019]; spleen development [GO:0048536]; steroid biosynthetic process [GO:0006694]; thymus development [GO:0048538]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=PBX1a; IsoId=P40424-1; Sequence=Displayed; Name=PBX1b; IsoId=P40424-2; Sequence=VSP_002271, VSP_002272; Name=3; IsoId=P40424-3; Sequence=VSP_044499; Note=No experimental confirmation available.; 


uniprotID: P40425
geneSymbol: PBX2
name: Pre-B-cell leukemia transcription factor 2 (Homeobox protein PBX2) (Protein G17)
length: 430
go: ENSG00000204304;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; transcription factor binding [GO:0008134]; embryonic limb morphogenesis [GO:0030326]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proximal/distal pattern formation [GO:0009954]


uniprotID: Q15366
geneSymbol: PCBP2
reactome: R-HSA-72163;R-HSA-72203;R-HSA-936440;
pdb: 2AXY;2JZX;2P2R;2PQU;2PY9;
name: Poly(rC)-binding protein 2 (Alpha-CP2) (Heterogeneous nuclear ribonucleoprotein E2) (hnRNP E2)
length: 365
go: ENSG00000197111;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; IRES-dependent viral translational initiation [GO:0075522]; mRNA metabolic process [GO:0016071]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of defense response to virus [GO:0050687]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; RNA metabolic process [GO:0016070]; viral RNA genome replication [GO:0039694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q15366-1; Sequence=Displayed; Name=2; IsoId=Q15366-2; Sequence=VSP_042833; Note=No experimental confirmation available.; Name=3; IsoId=Q15366-3; Sequence=VSP_043161, VSP_042833; Name=4; IsoId=Q15366-4; Sequence=VSP_043161, VSP_043362, VSP_042833; Note=No experimental confirmation available.; Name=5; IsoId=Q15366-5; Sequence=VSP_043362, VSP_042833; Note=No experimental confirmation available.; Name=6; IsoId=Q15366-6; Sequence=VSP_043161; Note=No experimental confirmation available.; Name=7; IsoId=Q15366-7; Sequence=VSP_043161, VSP_043362, VSP_054045; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=8; IsoId=Q15366-8; Sequence=VSP_043362, VSP_054045; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19029303}. Cytoplasm {ECO:0000269|PubMed:19029303}. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.


uniprotID: P57721
geneSymbol: PCBP3
length: 371
go: ENSG00000183570;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14612387}.
name:
Poly(rC)-binding protein 3 (Alpha-CP3) (PCBP3-overlapping transcript) (PCBP3-overlapping transcript 1)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; C-rich single-stranded DNA binding [GO:1990829]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; mRNA metabolic process [GO:0016071]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P57721-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=P57721-2; Sequence=VSP_009947, VSP_009948; Note=No experimental confirmation available.; Name=3; IsoId=P57721-3; Sequence=VSP_009947; Note=No experimental confirmation available.; Name=4; IsoId=P57721-4; Sequence=VSP_009948; Note=No experimental confirmation available.; Name=5; IsoId=P57721-5; Sequence=VSP_010014; Note=No experimental confirmation available.; 


uniprotID: Q9Y5E7
geneSymbol: PCDHB2
name: Protocadherin beta-2 (PCDH-beta-2)
length: 798
go: ENSG00000112852;
snps: rs31853 rs384081 rs1047372
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]


uniprotID: O14917
geneSymbol: PCDH17
name: Protocadherin-17 (Protocadherin-68)
length: 1159
go: ENSG00000118946;
sequence:

opentargets:
GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic membrane [GO:0099055]; integral component of presynaptic membrane [GO:0099056]; calcium ion binding [GO:0005509]; adult behavior [GO:0030534]; cell adhesion [GO:0007155]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of synaptic transmission [GO:0050805]; presynaptic active zone assembly [GO:1904071]; regulation of synaptic vesicle clustering [GO:2000807]; synaptic membrane adhesion [GO:0099560]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14917-1; Sequence=Displayed; Name=2; IsoId=O14917-2; Sequence=VSP_021581, VSP_021582; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q9Y5E1
geneSymbol: PCDHB9
name: Protocadherin beta-9 (PCDH-beta-9) (Protocadherin-3H)
length: 797
snps: rs2740588 rs11167742 rs17844512 rs11167743 rs10040383 rs2697530
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; synapse assembly [GO:0007416]


uniprotID: Q9Y5F2
geneSymbol: PCDHB11
name: Protocadherin beta-11 (PCDH-beta-11)
length: 797
go: ENSG00000197479;
snps: rs3756323 rs917535 rs799834
sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; calcium ion binding [GO:0005509]; calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0016339]; cell adhesion [GO:0007155]; chemical synaptic transmission [GO:0007268]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; nervous system development [GO:0007399]; synapse assembly [GO:0007416]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5F2-1; Sequence=Displayed; Name=2; IsoId=Q9Y5F2-2; Sequence=VSP_055931; Note=No experimental confirmation available.; 


uniprotID: P16499
geneSymbol: PDE6A
reactome: R-HSA-2485179;R-HSA-2514859;R-HSA-4086398;
length: 860
go: ENSG00000132915;
drug: DB00201;
name:
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (GMP-PDE alpha) (EC 3.1.4.35) (PDE V-B1)

sequence:

opentargets:
photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]; G protein-coupled receptor signaling pathway [GO:0007186]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; rhodopsin mediated signaling pathway [GO:0016056]; visual perception [GO:0007601]

snps:
rs750539462 rs141252097 rs35431421 rs10057110 rs145608358 rs114973968 rs121918577 rs61732059 rs17711594 rs139444207 rs755527251 rs780450680 rs138315990 


uniprotID: O95263
geneSymbol: PDE8B
reactome: R-HSA-418555;
length: 885
go: ENSG00000113231;
drug: DB00201;
snps: rs121918360
name:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (HsPDE8B) (EC 3.1.4.53) (Cell proliferation-inducing gene 22 protein)

sequence:

opentargets:
cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; G protein-coupled receptor signaling pathway [GO:0007186]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=PDE8B1; IsoId=O95263-1; Sequence=Displayed; Note=Major isoform.; Name=2; Synonyms=PDE8B2, PDE8B3; IsoId=O95263-2; Sequence=VSP_008084; Name=3; Synonyms=PDE8B3; IsoId=O95263-3; Sequence=VSP_008085; Name=4; Synonyms=PDE8B4; IsoId=O95263-4; Sequence=VSP_008082; Name=5; IsoId=O95263-5; Sequence=VSP_008081; Note=No experimental confirmation available.; Name=6; Synonyms=PDE8B2; IsoId=O95263-6; Sequence=VSP_008083; 


uniprotID: Q15116
geneSymbol: PDCD1
reactome: R-HSA-389948;
pdb: 2M2D;3RRQ;4ZQK;5B8C;5GGR;5GGS;5IUS;5JXE;5WT9;
name: Programmed cell death protein 1 (Protein PD-1) (hPD-1) (CD antigen CD279)
length: 288
go: ENSG00000188389;
drug: DB05916;DB09035;DB09037;
snps: rs2227982
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
sequence:

opentargets:
external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; humoral immune response [GO:0006959]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of tolerance induction [GO:0002644]; positive regulation of T cell apoptotic process [GO:0070234]; T cell costimulation [GO:0031295]


uniprotID: Q9BY77
geneSymbol: POLDIP3
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72187;
length: 421
go: ENSG00000100227;
name:
Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; poly(A)+ mRNA export from nucleus [GO:0016973]; positive regulation of translation [GO:0045727]; RNA export from nucleus [GO:0006405]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BY77-1; Sequence=Displayed; Name=2; IsoId=Q9BY77-2; Sequence=VSP_011056; 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein.


uniprotID: Q14691
geneSymbol: GINS1
reactome: R-HSA-176974;
pdb: 2E9X;2EHO;2Q9Q;
name: DNA replication complex GINS protein PSF1 (GINS complex subunit 1)
length: 196
go: ENSG00000101003;
snps: rs6076347
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:
MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIPTIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMAAEEMEWFNNYKRSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRWKCEQLIRQGVLEHILS

opentargets:
cytoplasm [GO:0005737]; GINS complex [GO:0000811]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' DNA helicase activity [GO:0043138]; DNA strand elongation involved in DNA replication [GO:0006271]; DNA strand elongation involved in mitotic DNA replication [GO:1902983]; inner cell mass cell proliferation [GO:0001833]


uniprotID: P11464
geneSymbol: PSG1
reactome: R-HSA-202733;
length: 419
go: ENSG00000231924;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]; leukocyte migration [GO:0050900]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 1 (PS-beta-G-1) (PSBG-1) (Pregnancy-specific glycoprotein 1) (CD66 antigen-like family member F) (Fetal liver non-specific cross-reactive antigen 1/2) (FL-NCA-1/2) (PSG95) (Pregnancy-specific beta-1 glycoprotein C/D) (PS-beta-C/D) (CD antigen CD66f)

sequence:

snps:
rs707744 rs707745 rs1058956 rs1064479 rs1064480 rs1058661 rs707748 rs1058960 rs1058671 rs1058692 rs1058693 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PSG-1a; IsoId=P11464-1; Sequence=Displayed; Name=2; IsoId=P11464-2; Sequence=VSP_002550; Name=3; IsoId=P11464-3; Sequence=VSP_002549; Name=4; Synonyms=PSG-1d; IsoId=P11464-4; Sequence=VSP_002548; 


uniprotID: P11465
geneSymbol: PSG2
reactome: R-HSA-202733;
length: 335
go: ENSG00000242221;
opentargets: extracellular region [GO:0005576]; cell migration [GO:0016477]; female pregnancy [GO:0007565]
snps: rs3887660 rs16976431 rs1058086 rs1064937
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 2 (PS-beta-G-2) (PSBG-2) (Pregnancy-specific glycoprotein 2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E)

sequence:


uniprotID: Q00888
geneSymbol: PSG4
reactome: R-HSA-202733;
length: 419
go: ENSG00000243137;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]
snps: rs11883278 rs3170216 rs73548061 rs3859474 rs1058718 rs2355442
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 4 (PS-beta-G-4) (PSBG-4) (Pregnancy-specific glycoprotein 4) (Pregnancy-specific beta-1-glycoprotein 9) (PS-beta-G-9) (PSBG-9) (Pregnancy-specific glycoprotein 9)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q00888-1; Sequence=Displayed; Name=2; IsoId=Q00888-2; Sequence=VSP_007875, VSP_040131; Name=3; IsoId=Q00888-3; Sequence=VSP_055025; Note=No experimental confirmation available. Derived from EST data.; 


uniprotID: Q15238
geneSymbol: PSG5
reactome: R-HSA-202733;
length: 335
go: ENSG00000204941;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]
snps: rs8107936 rs1058259 rs5013158 rs1058285
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 5 (PS-beta-G-5) (PSBG-5) (Pregnancy-specific glycoprotein 5) (Fetal liver non-specific cross-reactive antigen 3) (FL-NCA-3)

sequence:


uniprotID: Q00889
geneSymbol: PSG6
reactome: R-HSA-202733;
length: 435
go: ENSG00000170848;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Pregnancy-specific beta-1-glycoprotein 6 (PS-beta-G-6) (PSBG-6) (Pregnancy-specific glycoprotein 6) (Pregnancy-specific beta-1-glycoprotein 10) (PS-beta-G-10) (PSBG-10) (Pregnancy-specific glycoprotein 10) (Pregnancy-specific beta-1-glycoprotein 12) (PS-beta-G-12) (PSBG-12) (Pregnancy-specific glycoprotein 12)

sequence:

snps:
rs3198831 rs1058674 rs1058679 rs1058680 rs1065505 rs1065507 rs1065508 rs1065509 rs59587483 rs1058688 rs1065511 rs1065513 rs1058710 rs1065515 rs1065525 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q00889-1; Sequence=Displayed; Name=2; IsoId=Q00889-2; Sequence=VSP_039344; 


uniprotID: Q13046
geneSymbol: PSG7
reactome: R-HSA-202733;
length: 419
go: ENSG00000221878;
opentargets: extracellular region [GO:0005576]; female pregnancy [GO:0007565]
snps: rs7245978
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Putative pregnancy-specific beta-1-glycoprotein 7 (PS-beta-G-7) (PSBG-7) (Pregnancy-specific glycoprotein 7)

sequence:


uniprotID: Q9UQ74
geneSymbol: PSG8
reactome: R-HSA-202733;
name: Pregnancy-specific beta-1-glycoprotein 8 (PS-beta-G-8) (PSBG-8) (Pregnancy-specific glycoprotein 8)
length: 426
go: ENSG00000124467;
opentargets: extracellular region [GO:0005576]
snps: rs11879884 rs1064490
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UQ74-1; Sequence=Displayed; Name=2; IsoId=Q9UQ74-2; Sequence=VSP_041096, VSP_041097; Name=3; IsoId=Q9UQ74-3; Sequence=VSP_041097; 


uniprotID: Q8TAA3
geneSymbol: PSMA8
name: Proteasome subunit alpha-type 8 (EC 3.4.25.1) (Proteasome subunit alpha-type 7-like)
length: 256
go: ENSG00000154611;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-983168;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; proteasome core complex [GO:0005839]; proteasome core complex, alpha-subunit complex [GO:0019773]; spermatoproteasome complex [GO:1990111]; endopeptidase activity [GO:0004175]; threonine-type endopeptidase activity [GO:0004298]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; proteasomal ubiquitin-independent protein catabolic process [GO:0010499]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q8TAA3-1; Sequence=Displayed; Note=Predicted but not yet described.; Name=2; IsoId=Q8TAA3-2; Sequence=VSP_005285; Name=3; IsoId=Q8TAA3-5; Sequence=VSP_018602; Note=No experimental confirmation available.; 


uniprotID: Q15008
geneSymbol: PSMD6
length: 389
go: ENSG00000163636;
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-6798695;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

pdb:
5GJQ;5GJR;5L4K;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHS;

name:
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit RPN7) (26S proteasome regulatory subunit S10) (Breast cancer-associated protein SGA-113M) (Phosphonoformate immuno-associated protein 4) (Proteasome regulatory particle subunit p44S10) (p42A)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleoplasm [GO:0005654]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; secretory granule lumen [GO:0034774]; ATPase activity [GO:0016887]; enzyme regulator activity [GO:0030234]; neutrophil degranulation [GO:0043312]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q15008-1; Sequence=Displayed; Name=2; IsoId=Q15008-2; Sequence=VSP_047711; Name=3; IsoId=Q15008-3; Sequence=VSP_055177; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=4; IsoId=Q15008-4; Sequence=VSP_055178; Note=No experimental confirmation available.; 


uniprotID: P48556
geneSymbol: PSMD8
length: 350
go: ENSG00000099341;
pdb:
5GJQ;5GJR;5L4K;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHS;

name:
26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, lid subcomplex [GO:0008541]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]


uniprotID: Q8WXF1
geneSymbol: PSPC1
pdb: 3SDE;5IFN;5WPA;
name: Paraspeckle component 1 (Paraspeckle protein 1)
length: 523
go: ENSG00000121390;
sequence:

opentargets:
cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; paraspeckles [GO:0042382]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; RNA binding [GO:0003723]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; activation of innate immune response [GO:0002218]; innate immune response [GO:0045087]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=PSP1-alpha; IsoId=Q8WXF1-1; Sequence=Displayed; Name=2; Synonyms=PSP1-beta; IsoId=Q8WXF1-2; Sequence=VSP_027274, VSP_027275; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.


uniprotID: P11686
geneSymbol: SFTPC
reactome: R-HSA-5683826;R-HSA-5688354;R-HSA-5688849;R-HSA-5688890;
pdb: 2YAD;
length: 197
snps: rs4715 rs34957318 rs1124
location: SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
name:
Pulmonary surfactant-associated protein C (SP-C) (Pulmonary surfactant-associated proteolipid SPL(Val)) (SP5)

sequence:
MDVGSKEVLMESPPDYSAAPRGRFGIPCCPVHLKRLLIVVVVVVLIVVVIVGALLMGLHMSQKHTEMVLEMSIGAPEAQQRLALSEHLVTTATFSIGSTGLVVYDYQQLLIAYKPAPGTCCYIMKIAPESIPSLEALNRKVHNFQMECSLQAKPAVPTSKLGQAEGRDAGSAPSGGDPAFLGMAVNTLCGEVPLYYI

opentargets:
clathrin-coated endocytic vesicle [GO:0045334]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lamellar body [GO:0042599]; multivesicular body lumen [GO:0097486]; identical protein binding [GO:0042802]; cellular protein metabolic process [GO:0044267]; respiratory gaseous exchange [GO:0007585]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P11686-1; Sequence=Displayed; Name=2; Synonyms=C1; IsoId=P11686-2; Sequence=VSP_006311; 


uniprotID: O15018
geneSymbol: PDZD2
length: 2839
go: ENSG00000133401;
snps: rs57158698 rs3101878 rs157496 rs12520467 rs36097367 rs3101873 rs10066063
name:
PDZ domain-containing protein 2 (Activated in prostate cancer protein) (PDZ domain-containing protein 3) [Cleaved into: Processed PDZ domain-containing protein 2]

sequence:

opentargets:
cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; nucleus [GO:0005634]; cell adhesion [GO:0007155]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15018-1; Sequence=Displayed; Name=2; IsoId=O15018-2; Sequence=VSP_012369, VSP_012370, VSP_012371, VSP_012372, VSP_012373; Note=May be due to aberrant splicing.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QZR8}. Cytoplasm {ECO:0000269|PubMed:11289102}. Endoplasmic reticulum {ECO:0000269|PubMed:11289102}. Note=At cell-cell contacts in lung epithelial cells. {ECO:0000250|UniProtKB:Q9QZR8}.; SUBCELLULAR LOCATION: Processed PDZ domain-containing protein 2: Secreted {ECO:0000250}.


uniprotID: Q6ZS72
geneSymbol: PEAK3
name: Uncharacterized protein PEAK3
length: 473
go: ENSG00000188305;
opentargets: protein kinase activity [GO:0004672]; protein phosphorylation [GO:0006468]
sequence:


uniprotID: P30086
geneSymbol: PEBP1
reactome: R-HSA-5674135;R-HSA-5675221;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802955;
pdb: 1BD9;1BEH;2L7W;2QYQ;
length: 187
go: ENSG00000089220;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]

sequence:
MPVDLSKWSGPLSLQEVDEQPQHPLHVTYAGAAVDELGKVLTPTQVKNRPTSISWDGLDSGKLYTLVLTDPDAPSRKDPKYREWHHFLVVNMKGNDISSGTVLSDYVGSGPPKGTGLHRYVWLVYEQDRPLKCDEPILSNRSGDHRGKFKVASFRKKYELRAPVAGTCYQAEWDDYVPKLYEQLSGK

opentargets:
apical part of cell [GO:0045177]; axon terminus [GO:0043679]; cell surface [GO:0009986]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; synaptic vesicle [GO:0008021]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; mitogen-activated protein kinase binding [GO:0051019]; phosphatidylethanolamine binding [GO:0008429]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; serine-type endopeptidase inhibitor activity [GO:0004867]; signaling receptor binding [GO:0005102]; aging [GO:0007568]; hippocampus development [GO:0021766]; MAPK cascade [GO:0000165]; negative regulation of MAPK cascade [GO:0043409]; positive regulation of acetylcholine metabolic process [GO:0060409]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of mitotic nuclear division [GO:0045840]; regulation of neurotransmitter levels [GO:0001505]; regulation of the force of heart contraction [GO:0002026]; response to activity [GO:0014823]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to corticosterone [GO:0051412]; response to ethanol [GO:0045471]; response to heat [GO:0009408]; response to organonitrogen compound [GO:0010243]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; response to wounding [GO:0009611]; sperm capacitation [GO:0048240]


uniprotID: Q96S96
geneSymbol: PEBP4
name: Phosphatidylethanolamine-binding protein 4 (PEBP-4) (hPEBP4) (Protein cousin-of-RKIP 1)
length: 227
go: ENSG00000134020;
opentargets: extracellular exosome [GO:0070062]; lysosome [GO:0005764]
snps: rs1129474 rs1047406
location: SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:15302887}.
sequence:


uniprotID: Q13951
geneSymbol: CBFB
pdb: 1CL3;1E50;1H9D;4N9F;
length: 182
go: ENSG00000067955;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
reactome:
R-HSA-8877330;R-HSA-8878166;R-HSA-8931987;R-HSA-8934593;R-HSA-8935964;R-HSA-8936459;R-HSA-8939236;R-HSA-8939242;R-HSA-8939243;R-HSA-8939245;R-HSA-8939246;R-HSA-8939247;R-HSA-8939256;R-HSA-8939902;R-HSA-8940973;R-HSA-8941284;R-HSA-8941326;R-HSA-8941332;R-HSA-8941333;R-HSA-8941858;R-HSA-8949275;R-HSA-8951911;R-HSA-8951936;R-HSA-9018519;

name:
Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit)

sequence:
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLEREAGKVYLKAPMILNGVCVIWKGWIDLQRLDGMGCLEFDEERAQQEDALAQQAFEEARRRTREFEDRDRSHREEMEVRVSQLLAVTGKKTTRP

opentargets:
core-binding factor complex [GO:0016513]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; cell maturation [GO:0048469]; definitive hemopoiesis [GO:0060216]; lymphocyte differentiation [GO:0030098]; myeloid cell differentiation [GO:0030099]; negative regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043371]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043378]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein polyubiquitination [GO:0000209]; regulation of B cell receptor signaling pathway [GO:0050855]; regulation of bicellular tight junction assembly [GO:2000810]; regulation of cytokine-mediated signaling pathway [GO:0001959]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of keratinocyte differentiation [GO:0045616]; regulation of megakaryocyte differentiation [GO:0045652]; regulation of myeloid cell differentiation [GO:0045637]; regulation of regulatory T cell differentiation [GO:0045589]; regulation of Wnt signaling pathway [GO:0030111]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13951-1; Sequence=Displayed; Name=2; IsoId=Q13951-2; Sequence=VSP_036044; 


uniprotID: Q9BY49
geneSymbol: PECR
reactome: R-HSA-389599;R-HSA-9033241;
pdb: 1YXM;
length: 303
go: ENSG00000115425;
drug: DB00173;
snps: rs1429148 rs9288513
location: SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11669066}.
name:
Peroxisomal trans-2-enoyl-CoA reductase (TERP) (EC 1.3.1.38) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP) (HPDHase) (Short chain dehydrogenase/reductase family 29C member 1) (pVI-ARL)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; signaling receptor binding [GO:0005102]; trans-2-enoyl-CoA reductase (NADPH) activity [GO:0019166]; fatty acid alpha-oxidation [GO:0001561]; fatty acid biosynthetic process [GO:0006633]; oxidation-reduction process [GO:0055114]; phytol metabolic process [GO:0033306]; protein targeting to peroxisome [GO:0006625]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BY49-1; Sequence=Displayed; Name=2; IsoId=Q9BY49-2; Sequence=VSP_013260; 


uniprotID: Q9H1Q7
geneSymbol: PCED1A
name: PC-esterase domain-containing protein 1A (Protein FAM113A) (Sarcoma antigen NY-SAR-23)
length: 454
go: ENSG00000132635;
snps: rs2274670
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9H1Q7-1; Sequence=Displayed; Name=2; IsoId=Q9H1Q7-2; Sequence=VSP_003818; Name=3; IsoId=Q9H1Q7-3; Sequence=VSP_003818, VSP_003819; Name=4; IsoId=Q9H1Q7-4; Sequence=VSP_013917, VSP_013918; Note=No experimental confirmation available.; 


uniprotID: Q96HM7
geneSymbol: PCED1B
name: PC-esterase domain-containing protein 1B (Protein FAM113B)
length: 432
go: ENSG00000179715;
snps: rs2543737
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96HM7-1; Sequence=Displayed; Name=2; IsoId=Q96HM7-2; Sequence=VSP_033182, VSP_033183, VSP_033184; Note=No experimental confirmation available.; 


uniprotID: Q9UBV8
geneSymbol: PEF1
length: 284
go: ENSG00000162517;
name:
Peflin (PEF protein with a long N-terminal hydrophobic domain) (Penta-EF hand domain-containing protein 1)

sequence:

opentargets:
COPII vesicle coat [GO:0030127]; cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; molecular adaptor activity [GO:0060090]; protein dimerization activity [GO:0046983]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278427}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q641Z8}. Membrane {ECO:0000269|PubMed:11278427}; Peripheral membrane protein {ECO:0000269|PubMed:11278427}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:27716508}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the presence of Ca(2+) (PubMed:11278427). Localizes to endoplasmic reticulum exit site (ERES) (By similarity). {ECO:0000250|UniProtKB:Q641Z8, ECO:0000269|PubMed:11278427}.


uniprotID: P34995
geneSymbol: PTGER1
reactome: R-HSA-391908;R-HSA-416476;
length: 402
go: ENSG00000160951;
drug: DB00770;DB00905;DB00297;DB00429;DB00917;DB01088;
snps: rs1057362 rs28364042 rs7249305
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Prostaglandin E2 receptor EP1 subtype (PGE receptor EP1 subtype) (PGE2 receptor EP1 subtype) (Prostanoid EP1 receptor)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; D1 dopamine receptor binding [GO:0031748]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating dopamine receptor signaling pathway [GO:0007191]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of gastric emptying [GO:0120061]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]


uniprotID: P43116
geneSymbol: PTGER2
reactome: R-HSA-391908;R-HSA-418555;
length: 358
go: ENSG00000125384;
drug: DB00770;DB00917;DB00929;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Prostaglandin E2 receptor EP2 subtype (PGE receptor EP2 subtype) (PGE2 receptor EP2 subtype) (Prostanoid EP2 receptor)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to prostaglandin E stimulus [GO:0071380]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gastric mucosal blood circulation [GO:1904346]; regulation of cell proliferation [GO:0042127]; response to lipopolysaccharide [GO:0032496]; response to progesterone [GO:0032570]


uniprotID: P43115
geneSymbol: PTGER3
reactome: R-HSA-391908;R-HSA-418594;
length: 390
go: ENSG00000050628;
drug: DB00905;DB00917;DB00929;
snps: rs5670 rs13306020 rs13306014 rs5694
name:
Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)

sequence:

opentargets:
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; nuclear envelope [GO:0005635]; plasma membrane [GO:0005886]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell death [GO:0008219]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; intestine smooth muscle contraction [GO:0014827]; negative regulation of gastric acid secretion [GO:0060455]; phospholipase C-activating G protein-coupled receptor signaling pathway [GO:0007200]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of fever generation [GO:0031622]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=12;  Comment=Additional isoforms seem to exist.; Name=EP3A; Synonyms=EP3-I, EP3a1, EP3a2, EP(3-Ic); IsoId=P43115-1; Sequence=Displayed; Name=EP3C; Synonyms=EP3-II; IsoId=P43115-2; Sequence=VSP_001935; Note=Known as EP3D in Ref.7.; Name=EP3B; Synonyms=EP3-III; IsoId=P43115-3; Sequence=VSP_001936; Note=Known as EP3E in Ref.7.; Name=EP3D; Synonyms=EP3-IV; IsoId=P43115-4; Sequence=VSP_001937; Note=Known as EP3F in Ref.7.; Name=EP3E; IsoId=P43115-5; Sequence=VSP_001938; Name=EP3F; IsoId=P43115-6; Sequence=VSP_001939; Name=EP3G; IsoId=P43115-7; Sequence=VSP_013271; Name=EP3-III; IsoId=P43115-8; Sequence=VSP_053774; Name=EP3-IV; IsoId=P43115-9; Sequence=VSP_053775; Name=EP3-V; IsoId=P43115-10; Sequence=VSP_053776; Name=EP3E2; IsoId=P43115-11; Sequence=VSP_053777; Name=12; IsoId=P43115-12; Sequence=VSP_058943; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7883006, ECO:0000269|PubMed:7981210, ECO:0000269|PubMed:8117308, ECO:0000269|PubMed:8307176}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q8N2H9
geneSymbol: PELI3
reactome: R-HSA-9020702;R-HSA-937039;R-HSA-975144;
length: 469
go: ENSG00000174516;
snps: rs34989499
name:
E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 3)

sequence:

opentargets:
cytosol [GO:0005829]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase activity [GO:0061630]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; Toll signaling pathway [GO:0008063]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha, A; IsoId=Q8N2H9-1; Sequence=Displayed; Name=2; Synonyms=Beta, B; IsoId=Q8N2H9-2; Sequence=VSP_008640; Name=3; IsoId=Q8N2H9-3; Sequence=VSP_008639; Note=No experimental confirmation available.; Name=4; IsoId=Q8N2H9-4; Sequence=VSP_008641, VSP_008642; Note=No experimental confirmation available.; 


uniprotID: P0DJD8
geneSymbol: PGA3
reactome: R-HSA-5683826;
name: Pepsin A-3 (EC 3.4.23.1) (Pepsinogen-3)
length: 388
go: ENSG00000229859;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]; aspartic-type endopeptidase activity [GO:0004190]; peptidase activity [GO:0008233]; cellular protein metabolic process [GO:0044267]; digestion [GO:0007586]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]


uniprotID: P0DJD7
geneSymbol: PGA4
reactome: R-HSA-5683826;
pdb: 1FLH;1PSN;1PSO;1QRP;3UTL;
name: Pepsin A-4 (EC 3.4.23.1) (Pepsinogen-4)
length: 388
go: ENSG00000229183;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular exosome [GO:0070062]; multivesicular body lumen [GO:0097486]; aspartic-type endopeptidase activity [GO:0004190]; peptidase activity [GO:0008233]; cellular protein metabolic process [GO:0044267]; digestion [GO:0007586]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]


uniprotID: Q6ISU1
geneSymbol: PTCRA
reactome: R-HSA-9013508;
pdb: 3OF6;
name: Pre T-cell antigen receptor alpha (pT-alpha) (pTa) (pT-alpha-TCR)
length: 281
go: ENSG00000171611;
snps: rs9471966 rs36111725
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; negative regulation of thymocyte apoptotic process [GO:0070244]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=pTalpha-1; IsoId=Q6ISU1-1; Sequence=Displayed; Name=2; Synonyms=pTalpha-2; IsoId=Q6ISU1-2; Sequence=VSP_031445; Name=3; IsoId=Q6ISU1-3; Sequence=VSP_031446; 


uniprotID: O15534
geneSymbol: PER1
reactome: R-HSA-400253;
pdb: 1UL6;
length: 1290
go: ENSG00000179094;
snps: rs1464745710 rs2585405 rs3027193 rs1323588262 rs761958964
name:
Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; E-box binding [GO:0070888]; kinase binding [GO:0019900]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription corepressor binding [GO:0001222]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; circadian rhythm [GO:0007623]; entrainment of circadian clock [GO:0009649]; entrainment of circadian clock by photoperiod [GO:0043153]; histone H3 acetylation [GO:0043966]; histone H3 deacetylation [GO:0070932]; histone H4 acetylation [GO:0043967]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of JNK cascade [GO:0046329]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; posttranscriptional regulation of gene expression [GO:0010608]; regulation of circadian rhythm [GO:0042752]; regulation of cytokine production involved in inflammatory response [GO:1900015]; regulation of hair cycle [GO:0042634]; regulation of p38MAPK cascade [GO:1900744]; regulation of sodium ion transport [GO:0002028]; response to cAMP [GO:0051591]; response to light stimulus [GO:0009416]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Additional isoforms seem to exist.; Name=Rigui 4.7; IsoId=O15534-1; Sequence=Displayed; Name=Rigui 3.0; IsoId=O15534-2; Sequence=Not described; Name=Rigui 6.6; Synonyms=Truncated; IsoId=O15534-3; Sequence=Not described; Name=2; IsoId=O15534-4; Sequence=VSP_056205, VSP_056206, VSP_056207; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2 (By similarity). {ECO:0000250}.


uniprotID: P22079
geneSymbol: LPO
name: Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO)
length: 712
go: ENSG00000167419;
snps: rs8178318 rs8178338 rs8178355 rs2301870 rs8178401 rs8178408 rs8178412
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12626341}.
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; thiocyanate peroxidase activity [GO:0036393]; defense response to bacterium [GO:0042742]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; hydrogen peroxide catabolic process [GO:0042744]; response to oxidative stress [GO:0006979]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=P22079-1; Sequence=Displayed; Name=2; Synonyms=V3; IsoId=P22079-2; Sequence=VSP_044473; 


uniprotID: Q5SV97
geneSymbol: PERM1
reactome: R-HSA-2151201;
length: 790
go: ENSG00000187642;
name:
PGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; regulation of transcription, DNA-templated [GO:0006355]; response to muscle activity [GO:0014850]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5SV97-1; Sequence=Displayed; Name=2; IsoId=Q5SV97-2; Sequence=VSP_027731; Note=No experimental confirmation available.; Name=3; IsoId=Q5SV97-3; Sequence=VSP_053677; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q149B8}. Nucleus {ECO:0000250|UniProtKB:Q149B8}. Note=Shows a nuclear localization in the presence of PPARGC1A. {ECO:0000250|UniProtKB:Q149B8}.


uniprotID: P05164
geneSymbol: MPO
reactome: R-HSA-6798695;
pdb: 1CXP;1D2V;1D5L;1D7W;1DNU;1DNW;1MHL;1MYP;3F9P;3ZS0;3ZS1;4C1M;4DL1;4EJX;5FIW;5MFA;5UZU;6AZP;6BMT;
length: 745
go: ENSG00000005381;
snps: rs7208693 rs78950939 rs56378716 rs762688992 rs119468010 rs35670089 rs35702888 rs2759
location: SUBCELLULAR LOCATION: Lysosome.
name:
Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase; 89 kDa myeloperoxidase; 84 kDa myeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain]

sequence:

opentargets:
azurophil granule [GO:0042582]; azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleus [GO:0005634]; secretory granule [GO:0030141]; chromatin binding [GO:0003682]; heme binding [GO:0020037]; heparin binding [GO:0008201]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; aging [GO:0007568]; defense response [GO:0006952]; defense response to bacterium [GO:0042742]; defense response to fungus [GO:0050832]; hydrogen peroxide catabolic process [GO:0042744]; hypochlorous acid biosynthetic process [GO:0002149]; low-density lipoprotein particle remodeling [GO:0034374]; negative regulation of apoptotic process [GO:0043066]; negative regulation of growth of symbiont in host [GO:0044130]; neutrophil degranulation [GO:0043312]; oxidation-reduction process [GO:0055114]; removal of superoxide radicals [GO:0019430]; respiratory burst involved in defense response [GO:0002679]; response to food [GO:0032094]; response to gold nanoparticle [GO:1990268]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to oxidative stress [GO:0006979]; response to yeast [GO:0001878]

drug:
DB00233;DB00006;DB02300;DB06774;DB00958;DB00833;DB00535;DB00515;DB00847;DB00250;DB05161;DB01225;DB04827;DB00062;DB00583;DB01065;DB00244;DB00461;DB04821;DB00104;DB00526;DB00550;DB00208;DB06823;DB00500;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=H17; Synonyms=B; IsoId=P05164-1; Sequence=Displayed; Name=H14; IsoId=P05164-2; Sequence=VSP_007206; Name=H7; Synonyms=A; IsoId=P05164-3; Sequence=VSP_007207; 


uniprotID: O15055
geneSymbol: PER2
reactome: R-HSA-400253;
name: Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
length: 1255
go: ENSG00000132326;
snps: rs35572922 rs121908635 rs4429421 rs35333999 rs35998480 rs934945
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription coactivator activity [GO:0003713]; transcription corepressor binding [GO:0001222]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; circadian regulation of gene expression [GO:0032922]; circadian regulation of translation [GO:0097167]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; fatty acid metabolic process [GO:0006631]; gluconeogenesis [GO:0006094]; glycogen biosynthetic process [GO:0005978]; histone H3 deacetylation [GO:0070932]; lactate biosynthetic process [GO:0019249]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of fat cell proliferation [GO:0070345]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription regulatory region DNA binding [GO:2000678]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cell cycle [GO:0051726]; regulation of circadian rhythm [GO:0042752]; regulation of glutamate uptake involved in transmission of nerve impulse [GO:0051946]; regulation of insulin secretion [GO:0050796]; regulation of neurogenesis [GO:0050767]; regulation of vasoconstriction [GO:0019229]; response to ischemia [GO:0002931]; response to light stimulus [GO:0009416]; white fat cell differentiation [GO:0050872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15055-1; Sequence=Displayed; Name=2; Synonyms=PER2S; IsoId=O15055-2; Sequence=VSP_021653, VSP_021654; 

location:
SUBCELLULAR LOCATION: Isoform 1: Nucleus. Cytoplasm {ECO:0000250|UniProtKB:O54943}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization.; SUBCELLULAR LOCATION: Isoform 2: Nucleus, nucleolus {ECO:0000269|PubMed:24202686}.


uniprotID: P41222
geneSymbol: PTGDS
reactome: R-HSA-2162123;
pdb: 2WWP;3O19;3O22;3O2Y;4IMN;4IMO;4ORR;4ORS;4ORU;4ORW;4ORX;4ORY;4OS0;4OS3;4OS8;5WY9;
length: 190
go: ENSG00000107317;
snps: rs11552179
name:
Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)

sequence:
MATHHTLWMGLALLGVLGDLQAAPEAQVSVQPNFQQDKFLGRWFSAGLASNSSWLREKKAALSMCKSVVAPATDGGLNLTSTFLRKNQCETRTMLLQPAGSLGSYSYRSPHWGSTYSVSVVETDYDQYALLYSQGSKGPGEDFRMATLYSRTQTPRAELKEKFTAFCKAQGFTEDTIVFLPQTDKCMTEQ

opentargets:
endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; rough endoplasmic reticulum [GO:0005791]; fatty acid binding [GO:0005504]; prostaglandin-D synthase activity [GO:0004667]; retinoid binding [GO:0005501]; cyclooxygenase pathway [GO:0019371]; prostaglandin biosynthetic process [GO:0001516]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]

location:
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000269|PubMed:9065498}. Nucleus membrane {ECO:0000269|PubMed:9065498}. Golgi apparatus {ECO:0000269|PubMed:9065498}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9065498}. Secreted {ECO:0000269|PubMed:9065498}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted.


uniprotID: P56645
geneSymbol: PER3
length: 1201
go: ENSG00000049246;
name:
Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; kinase binding [GO:0019900]; transcription corepressor binding [GO:0001222]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; ubiquitin protein ligase binding [GO:0031625]; circadian regulation of gene expression [GO:0032922]; entrainment of circadian clock by photoperiod [GO:0043153]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein stabilization [GO:0050821]; regulation of circadian sleep/wake cycle, sleep [GO:0045187]; response to light stimulus [GO:0009416]

snps:
rs150812083 rs139315125 rs10462020 rs228696 rs228697 rs57875989 rs1776342 rs12033719 rs2640909 rs2640905 rs10462021 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P56645-1; Sequence=Displayed; Name=2; IsoId=P56645-2; Sequence=VSP_040326, VSP_040327, VSP_040328; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26903630}. Nucleus {ECO:0000269|PubMed:26903630}. Note=Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS. {ECO:0000250|UniProtKB:O70361}.


uniprotID: Q8N4Q0
geneSymbol: ZADH2
pdb: 2C0C;2WEK;2X1H;2X7H;
length: 377
go: ENSG00000180011;
snps: rs17056661
location: SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q8BGC4}.
name:
Prostaglandin reductase 3 (PRG-3) (EC 1.3.1.48) (Zinc-binding alcohol dehydrogenase domain-containing protein 2)

sequence:

opentargets:
peroxisome [GO:0005777]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; zinc ion binding [GO:0008270]; negative regulation of fat cell differentiation [GO:0045599]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N4Q0-1; Sequence=Displayed; Name=2; IsoId=Q8N4Q0-2; Sequence=VSP_055796; Note=No experimental confirmation available.; 


uniprotID: P12272
geneSymbol: PTHLH
reactome: R-HSA-373080;R-HSA-418555;
pdb: 1BZG;1ET3;1M5N;3FFD;3H3G;
length: 177
go: ENSG00000087494;
snps: rs267606986 rs267606985
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Secreted.
name:
Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]

sequence:
MQRRLVQQWSVAVFLLSYAVPSCGRSVEGLSRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPSPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRKEQEKKKRRTRSAWLDSGVTGSGLEGDHLSDTSTTSLELDSRRH

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; hormone activity [GO:0005179]; peptide hormone receptor binding [GO:0051428]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; epidermis development [GO:0008544]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chondrocyte development [GO:0061182]; negative regulation of chondrocyte differentiation [GO:0032331]; osteoblast development [GO:0002076]; positive regulation of cell proliferation [GO:0008284]; regulation of gene expression [GO:0010468]; skeletal system development [GO:0001501]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=P12272-1; Sequence=Displayed; Name=2; IsoId=P12272-2; Sequence=VSP_004534; Name=3; IsoId=P12272-3; Sequence=VSP_004535; 


uniprotID: O00628
geneSymbol: PEX7
reactome: R-HSA-9033241;
name: Peroxisomal targeting signal 2 receptor (PTS2 receptor) (Peroxin-7)
length: 323
go: ENSG00000112357;
snps: rs61753233 rs121909152 rs121909151
location: SUBCELLULAR LOCATION: Peroxisome. Cytoplasm.
sequence:

opentargets:
cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; enzyme binding [GO:0019899]; peroxisome matrix targeting signal-2 binding [GO:0005053]; protein homodimerization activity [GO:0042803]; endochondral ossification [GO:0001958]; ether lipid biosynthetic process [GO:0008611]; fatty acid beta-oxidation [GO:0006635]; neuron migration [GO:0001764]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein targeting to peroxisome [GO:0006625]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00628-1; Sequence=Displayed; Name=2; IsoId=O00628-2; Sequence=VSP_056393; Note=No experimental confirmation available.; 


uniprotID: Q9NQP4
geneSymbol: PFDN4
reactome: R-HSA-389957;
name: Prefoldin subunit 4 (Protein C-1)
length: 134
go: ENSG00000101132;
sequence:
MAATMKKAAAEDVNVTFEDQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQRVLADLKVQLYAKFGSNINLEADES

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; prefoldin complex [GO:0016272]; chaperone binding [GO:0051087]; unfolded protein binding [GO:0051082]; protein folding [GO:0006457]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.


uniprotID: O76083
geneSymbol: PDE9A
reactome: R-HSA-418457;
name: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)
length: 593
go: ENSG00000160191;
drug: DB07954;DB00201;DB03597;
pdb:
2HD1;2YY2;3DY8;3DYL;3DYN;3DYQ;3DYS;3JSI;3JSW;3K3E;3K3H;3N3Z;3QI3;3QI4;4E90;4G2J;4G2L;4GH6;4Y86;4Y87;4Y8C;

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; ruffle membrane [GO:0032587]; sarcolemma [GO:0042383]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; 3',5'-cyclic-nucleotide phosphodiesterase activity [GO:0004114]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cGMP catabolic process [GO:0046069]; cGMP metabolic process [GO:0046068]; cGMP-mediated signaling [GO:0019934]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=16;  Name=PDE9A1; IsoId=O76083-1; Sequence=Displayed; Name=PDE9A2; IsoId=O76083-2; Sequence=VSP_004599; Name=PDE9A3; IsoId=O76083-3; Sequence=VSP_004598, VSP_004599; Name=PDE9A4; IsoId=O76083-4; Sequence=VSP_004600; Name=PDE9A5; IsoId=O76083-5; Sequence=VSP_017309; Name=PDE9A6; Synonyms=PDE9A5; IsoId=O76083-6; Sequence=VSP_017305, VSP_004599; Name=PDE9A7; Synonyms=PDE9A8, PDE9A14, PDE9A19, PDE9A20; IsoId=O76083-7; Sequence=VSP_017303; Name=PDE9A9; IsoId=O76083-8; Sequence=VSP_017307, VSP_004599; Name=PDE9A10; IsoId=O76083-9; Sequence=VSP_017304, VSP_017310; Name=PDE9A11; Synonyms=PDE9A15; IsoId=O76083-10; Sequence=VSP_017302, VSP_017311; Name=PDE9A12; IsoId=O76083-11; Sequence=VSP_017305, VSP_017308; Name=PDE9A13; IsoId=O76083-12; Sequence=VSP_017306; Name=PDE9A16; IsoId=O76083-13; Sequence=VSP_004598; Name=PDE9A17; IsoId=O76083-14; Sequence=VSP_017305; Name=PDE9A18; IsoId=O76083-15; Sequence=VSP_017307; Name=PDE9A21; IsoId=O76083-16; Sequence=VSP_038647, VSP_004599; 

location:
SUBCELLULAR LOCATION: Isoform PDE9A1: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}. Golgi apparatus {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25799991}.; SUBCELLULAR LOCATION: Isoform PDE9A2: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}.; SUBCELLULAR LOCATION: Isoform PDE9A3: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.; SUBCELLULAR LOCATION: Isoform PDE9A17: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.


uniprotID: Q8N807
geneSymbol: PDILT
pdb: 4NWY;5XF7;
name: Protein disulfide-isomerase-like protein of the testis
length: 584
go: ENSG00000169340;
snps: rs9926580 rs773495613 rs11648131 rs11865916 rs4500734 rs9652589 rs9652588
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; protein disulfide isomerase activity [GO:0003756]; cell migration [GO:0016477]; cell redox homeostasis [GO:0045454]; multicellular organism development [GO:0007275]; peptidyl-proline hydroxylation [GO:0019511]; protein folding [GO:0006457]; spermatid development [GO:0007286]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:15475357}.


uniprotID: Q53EL6
geneSymbol: PDCD4
reactome: R-HSA-8950505;
pdb: 2GGF;2KZT;2RG8;2ZU6;3EIJ;
length: 469
go: ENSG00000150593;
snps: rs7081726 rs11548765
name:
Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; BMP signaling pathway [GO:0030509]; cell aging [GO:0007569]; cellular response to lipopolysaccharide [GO:0071222]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; interleukin-12-mediated signaling pathway [GO:0035722]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle [GO:0045786]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of myofibroblast differentiation [GO:1904761]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of vascular smooth muscle cell differentiation [GO:1905064]; negative regulation of vascular smooth muscle cell proliferation [GO:1904706]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of inflammatory response [GO:0050729]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q53EL6-1; Sequence=Displayed; Name=2; IsoId=Q53EL6-2; Sequence=VSP_045622; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61823}. Cytoplasm {ECO:0000250|UniProtKB:Q61823}. Note=Shuttles between the nucleus and cytoplasm (By similarity). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (PubMed:16357133). {ECO:0000269|PubMed:16357133}.


uniprotID: Q8N165
geneSymbol: PDIK1L
name: Serine/threonine-protein kinase PDIK1L (EC 2.7.11.1) (PDLIM1-interacting kinase 1-like)
length: 341
go: ENSG00000175087;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14631099}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; meiotic cell cycle [GO:0051321]


uniprotID: Q9GZP0
geneSymbol: PDGFD
reactome: R-HSA-186797;
length: 370
go: ENSG00000170962;
drug: DB05139;DB05465;
snps: rs35045740
name:
Platelet-derived growth factor D (PDGF-D) (Iris-expressed growth factor) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)]

sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; cellular response to amino acid stimulus [GO:0071230]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to transforming growth factor beta stimulus [GO:0071560]; multicellular organism development [GO:0007275]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of monocyte extravasation [GO:2000439]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of smooth muscle cell chemotaxis [GO:0071673]; positive regulation of smooth muscle cell proliferation [GO:0048661]; regulation of peptidyl-tyrosine phosphorylation [GO:0050730]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Long, SCDGF-B-L; IsoId=Q9GZP0-1; Sequence=Displayed; Name=2; Synonyms=Short, SCDGF-B-S; IsoId=Q9GZP0-2; Sequence=VSP_020615; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.


uniprotID: Q8N8D1
geneSymbol: PDCD7
reactome: R-HSA-72165;
name: Programmed cell death protein 7 (ES18) (hES18)
length: 485
go: ENSG00000090470;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; response to glucocorticoid [GO:0051384]; RNA splicing [GO:0008380]


uniprotID: O75475
geneSymbol: PSIP1
reactome: R-HSA-162592;R-HSA-164843;R-HSA-175567;R-HSA-177539;R-HSA-180689;R-HSA-180910;
pdb: 1Z9E;2B4J;2M16;2MSR;2MTN;2N3A;3F9K;3HPG;3HPH;3U88;3ZEH;4FU6;5N88;5OYM;5YI9;6EMO;6EMP;6EMQ;6EMR;
length: 530
go: ENSG00000164985;
name:
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear heterochromatin [GO:0005720]; nuclear periphery [GO:0034399]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]; activating transcription factor binding [GO:0033613]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; supercoiled DNA binding [GO:0097100]; transcription coactivator activity [GO:0003713]; establishment of integrated proviral latency [GO:0075713]; mRNA 5'-splice site recognition [GO:0000395]; nuclear transport [GO:0051169]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to heat [GO:0009408]; response to oxidative stress [GO:0006979]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=p75, PSIP1; IsoId=O75475-1; Sequence=Displayed; Note=Less active than isoform 2 as transcriptional coactivator, but more abundant in cells.; Name=2; Synonyms=p52, PSIP2; IsoId=O75475-2; Sequence=VSP_014297, VSP_014298; Name=3; IsoId=O75475-3; Sequence=VSP_044435; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15642333, ECO:0000269|PubMed:9885563}. Note=Remains chromatin-associated throughout the cell cycle.


uniprotID: Q99460
geneSymbol: PSMD1
length: 953
go: ENSG00000173692;
reactome:
R-HSA-1169091;R-HSA-1234176;R-HSA-1236974;R-HSA-1236978;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-180534;R-HSA-180585;R-HSA-187577;R-HSA-195253;R-HSA-202424;R-HSA-211733;R-HSA-2467813;R-HSA-2871837;R-HSA-349425;R-HSA-350562;R-HSA-382556;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5658442;R-HSA-5668541;R-HSA-5676590;R-HSA-5678895;R-HSA-5687128;R-HSA-5689603;R-HSA-5689880;R-HSA-6798695;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69481;R-HSA-69601;R-HSA-8852276;R-HSA-8854050;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948751;R-HSA-8951664;R-HSA-9010553;R-HSA-9020702;R-HSA-9604323;R-HSA-983168;

pdb:
5GJQ;5GJR;5L4K;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5V1Y;5V1Z;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHS;6CO4;

name:
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)

sequence:

opentargets:
azurophil granule lumen [GO:0035578]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle [GO:0005838]; proteasome regulatory particle, base subcomplex [GO:0008540]; proteasome storage granule [GO:0034515]; enzyme regulator activity [GO:0030234]; ubiquitin protein ligase binding [GO:0031625]; neutrophil degranulation [GO:0043312]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; regulation of protein catabolic process [GO:0042176]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99460-1; Sequence=Displayed; Name=2; IsoId=Q99460-2; Sequence=VSP_011475; Note=No experimental confirmation available.; 


uniprotID: O43242
geneSymbol: PSMD3
length: 534
go: ENSG00000108344;
pdb:
5GJQ;5GJR;5L4K;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHS;

name:
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit RPN3) (26S proteasome regulatory subunit S3) (Proteasome subunit p58)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, lid subcomplex [GO:0008541]; secretory granule lumen [GO:0034774]; enzyme regulator activity [GO:0030234]; neutrophil degranulation [GO:0043312]; post-translational protein modification [GO:0043687]; protein deubiquitination [GO:0016579]; regulation of protein catabolic process [GO:0042176]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43242-1; Sequence=Displayed; Name=2; IsoId=O43242-2; Sequence=VSP_056362, VSP_056363; Note=No experimental confirmation available.; 


uniprotID: P55036
geneSymbol: PSMD4
length: 377
go: ENSG00000159352;
pdb:
1P9C;1P9D;1UEL;1YX4;1YX5;1YX6;2KDE;2KDF;5GJQ;5GJR;5L4K;5LN3;5M32;5T0C;5T0G;5T0H;5T0I;5T0J;5VFP;5VFQ;5VFR;5VFS;5VFT;5VFU;5VGZ;5VHF;5VHH;5VHI;5VHS;

name:
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; proteasome accessory complex [GO:0022624]; proteasome complex [GO:0000502]; proteasome regulatory particle, base subcomplex [GO:0008540]; identical protein binding [GO:0042802]; polyubiquitin modification-dependent protein binding [GO:0031593]; RNA binding [GO:0003723]; post-translational protein modification [GO:0043687]; proteasome assembly [GO:0043248]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=Rpn10A; IsoId=P55036-1; Sequence=Displayed; Name=Rpn10E; IsoId=P55036-2; Sequence=VSP_005291, VSP_005292; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q13113
geneSymbol: PDZK1IP1
name: PDZK1-interacting protein 1 (17 kDa membrane-associated protein) (Protein DD96)
length: 114
go: ENSG00000162366;
opentargets: extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein.
sequence:
MSALSLLILGLLTAVPPASCQQGLGNLQPWMQGLIAVAVFLVLVAIAFAVNHFWCQEEPEPAHMILTVGNKADGVLVGTDGRYSSMAASFRSSEHENAYENVPEEEGKVRSTPM


uniprotID: A8MUH7
geneSymbol: PDZK1P1
length: 402
name:
Putative PDZ domain-containing protein PDZK1P1 (PDZ domain-containing 1 pseudogene 1) (PDZ domain-containing 1 pseudogene 2)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A8MUH7-1; Sequence=Displayed; Name=2; IsoId=A8MUH7-2; Sequence=VSP_034752, VSP_034753, VSP_034754; Note=No experimental confirmation available.; 


uniprotID: Q76G19
geneSymbol: PDZD4
name: PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein)
length: 769
go: ENSG00000067840;
snps: rs782272149
sequence:

opentargets:
cell cortex [GO:0005938]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q76G19-1; Sequence=Displayed; Name=2; IsoId=Q76G19-2; Sequence=VSP_054521; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:15077175}. Note=Mainly localized under the plasma membrane.


uniprotID: Q9H5P4
geneSymbol: PDZD7
pdb: 2EEH;
name: PDZ domain-containing protein 7
length: 517
go: ENSG00000186862;
sequence:

opentargets:
cilium [GO:0005929]; extracellular space [GO:0005615]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; auditory receptor cell stereocilium organization [GO:0060088]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; establishment of protein localization [GO:0045184]; sensory perception of sound [GO:0007605]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H5P4-1; Sequence=Displayed; Name=2; IsoId=Q9H5P4-2; Sequence=VSP_015075, VSP_015076; Note=No experimental confirmation available.; Name=3; IsoId=Q9H5P4-3; Sequence=VSP_039972, VSP_039973; Note=A nonsense substitution at codon 526 is predicted to result in stop gain and protein truncation (in DFNB57) (Ref.7). A nonsense substitution at codon 550 is predicted to result in stop gain and protein truncation (in DFNB57) (Ref.8). {ECO:0000269|PubMed:26416264, ECO:0000269|PubMed:26849169}; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:20440071}. Nucleus {ECO:0000269|PubMed:20440071}.


uniprotID: Q5VY43
geneSymbol: PEAR1
length: 1037
go: ENSG00000187800;
snps: rs1952294 rs822442 rs11264581 rs12137505
name:
Platelet endothelial aggregation receptor 1 (hPEAR1) (Multiple epidermal growth factor-like domains protein 12) (Multiple EGF-like domains protein 12)

sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular [GO:0005622]; phagocytic cup [GO:0001891]; signaling receptor activity [GO:0038023]; negative regulation of Notch signaling pathway [GO:0045746]; phosphatidylinositol 3-kinase signaling [GO:0014065]; platelet aggregation [GO:0070527]; protein kinase B signaling [GO:0043491]; recognition of apoptotic cell [GO:0043654]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Detected on the cell surface in resting platelets. {ECO:0000269|PubMed:15851471}.


uniprotID: Q9GZU2
geneSymbol: PEG3
pdb: 4BHX;
name: Paternally-expressed gene 3 protein (Zinc finger and SCAN domain-containing protein 24)
length: 1588
go: ENSG00000198300;
snps: rs2191432 rs754473044 rs36016896 rs7251798 rs35851866 rs10412932 rs34831553 rs34051133
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
autophagosome [GO:0005776]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; apoptotic process [GO:0006915]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9GZU2-1; Sequence=Displayed; Name=2; IsoId=Q9GZU2-2; Sequence=VSP_020371; Name=3; IsoId=Q9GZU2-3; Sequence=VSP_020372, VSP_020373, VSP_020374; Name=4; IsoId=Q9GZU2-4; Sequence=VSP_020371, VSP_045527, VSP_045528; 


uniprotID: P35408
geneSymbol: PTGER4
reactome: R-HSA-391908;R-HSA-418555;
length: 488
go: ENSG00000171522;
drug: DB00917;DB00929;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)

sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; prostaglandin E receptor activity [GO:0004957]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; bone development [GO:0060348]; cellular response to mechanical stimulus [GO:0071260]; cellular response to prostaglandin E stimulus [GO:0071380]; ERK1 and ERK2 cascade [GO:0070371]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; JNK cascade [GO:0007254]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of eosinophil extravasation [GO:2000420]; negative regulation of inflammatory response [GO:0050728]; negative regulation of integrin activation [GO:0033624]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of inflammatory response [GO:0050729]; regulation of ossification [GO:0030278]; regulation of stress fiber assembly [GO:0051492]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; T-helper cell differentiation [GO:0042093]


uniprotID: O60437
geneSymbol: PPL
reactome: R-HSA-6809371;R-HSA-8851680;
pdb: 4Q28;
length: 1756
go: ENSG00000118898;
name:
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)

sequence:

opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; desmosome [GO:0030057]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cornification [GO:0070268]; intermediate filament cytoskeleton organization [GO:0045104]; response to mechanical stimulus [GO:0009612]; wound healing [GO:0042060]

snps:
rs8063727 rs35300633 rs1049205 rs34936263 rs2734742 rs35869286 rs2075639 rs12446946 rs2037912 rs35865314 

location:
SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000269|PubMed:9412476}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9412476}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Associated with desmosomes and intermediate filaments.


uniprotID: P06454
geneSymbol: PTMA
pdb: 2L9I;2MNQ;
name: Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]
length: 111
go: ENSG00000187514;
location: SUBCELLULAR LOCATION: Nucleus.
sequence:
MSDAAVDTSSEITTKDLKEKKEVVEEAENGRDAPANGNAENEENGEQEADNEVDEEEEEGGEEEEEEEEGDGEEEDGDEDEEAESATGKRAAEDDEDDDVDTKKQKTDEDD

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; activating transcription factor binding [GO:0033613]; histone binding [GO:0042393]; histone exchange [GO:0043486]; transcription, DNA-templated [GO:0006351]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P06454-1; Sequence=Displayed; Name=2; IsoId=P06454-2; Sequence=VSP_011508; 


uniprotID: Q06124
geneSymbol: PTPN11
length: 597
go: ENSG00000179295;
drug: DB02779;
reactome:
R-HSA-1059683;R-HSA-109704;R-HSA-110056;R-HSA-112411;R-HSA-114604;R-HSA-1170546;R-HSA-1257604;R-HSA-1295596;R-HSA-1433557;R-HSA-180292;R-HSA-186763;R-HSA-210990;R-HSA-210993;R-HSA-2219530;R-HSA-2586552;R-HSA-388841;R-HSA-389513;R-HSA-389948;R-HSA-391160;R-HSA-418886;R-HSA-432142;R-HSA-512988;R-HSA-5654689;R-HSA-5654693;R-HSA-5654695;R-HSA-5654700;R-HSA-5654706;R-HSA-5654710;R-HSA-5654712;R-HSA-5654720;R-HSA-5654726;R-HSA-5654727;R-HSA-5654732;R-HSA-5654733;R-HSA-6811558;R-HSA-877312;R-HSA-8853659;R-HSA-8854691;R-HSA-8865999;R-HSA-8934593;R-HSA-9008059;R-HSA-9028731;R-HSA-909733;R-HSA-912694;R-HSA-936964;

pdb:
2SHP;3B7O;3MOW;3O5X;3TKZ;3TL0;3ZM0;3ZM1;3ZM2;3ZM3;4DGP;4DGX;4GWF;4H1O;4H34;4JE4;4JEG;4JMG;4NWF;4NWG;4OHD;4OHE;4OHH;4OHI;4OHL;4PVG;4QSY;4RDD;5DF6;5EHP;5EHR;5I6V;5IBM;5IBS;5X7B;5X94;5XZR;6ATD;6BMR;6BMU;6BMV;6BMW;6BMX;6BMY;6BN5;

name:
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; cell adhesion molecule binding [GO:0050839]; D1 dopamine receptor binding [GO:0031748]; insulin receptor binding [GO:0005158]; insulin receptor substrate binding [GO:0043560]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; peptide hormone receptor binding [GO:0051428]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; phospholipase binding [GO:0043274]; phosphoprotein phosphatase activity [GO:0004721]; phosphotyrosine residue binding [GO:0001784]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; SH3/SH2 adaptor activity [GO:0005070]; abortive mitotic cell cycle [GO:0033277]; activation of MAPK activity [GO:0000187]; atrioventricular canal development [GO:0036302]; axon guidance [GO:0007411]; Bergmann glial cell differentiation [GO:0060020]; brain development [GO:0007420]; cellular response to cytokine stimulus [GO:0071345]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to mechanical stimulus [GO:0071260]; cerebellar cortex formation [GO:0021697]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage checkpoint [GO:0000077]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; ERBB signaling pathway [GO:0038127]; face morphogenesis [GO:0060325]; fibroblast growth factor receptor signaling pathway [GO:0008543]; genitalia development [GO:0048806]; glucose homeostasis [GO:0042593]; heart development [GO:0007507]; homeostasis of number of cells within a tissue [GO:0048873]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; inner ear development [GO:0048839]; integrin-mediated signaling pathway [GO:0007229]; interleukin-6-mediated signaling pathway [GO:0070102]; intestinal epithelial cell migration [GO:0061582]; leukocyte migration [GO:0050900]; megakaryocyte development [GO:0035855]; microvillus organization [GO:0032528]; multicellular organism growth [GO:0035264]; multicellular organismal reproductive process [GO:0048609]; negative regulation of cell adhesion mediated by integrin [GO:0033629]; negative regulation of cortisol secretion [GO:0051463]; negative regulation of growth hormone secretion [GO:0060125]; negative regulation of insulin secretion [GO:0046676]; neurotrophin TRK receptor signaling pathway [GO:0048011]; organ growth [GO:0035265]; peptidyl-tyrosine dephosphorylation [GO:0035335]; platelet activation [GO:0030168]; platelet formation [GO:0030220]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose import [GO:0046326]; positive regulation of hormone secretion [GO:0046887]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of multicellular organism growth [GO:0040014]; regulation of protein complex assembly [GO:0043254]; regulation of protein export from nucleus [GO:0046825]; regulation of type I interferon-mediated signaling pathway [GO:0060338]; T cell costimulation [GO:0031295]; triglyceride metabolic process [GO:0006641]

snps:
rs267606990 rs397507501 rs397507506 rs886043790 rs397507509 rs397507509 rs121918461 rs397507510 rs121918461 rs397507510 rs121918460 rs121918459 rs397507511 rs397507511 rs397507512 rs121918454 rs121918453 rs121918453 rs121918454 rs121918462 rs121918465 rs397507514 rs121918465 rs121918464 rs121918465 rs121918466 rs397507517 rs397507520 rs397507523 rs397507525 rs765642157 rs397507526 rs376607329 rs121918456 rs121918456 rs397507529 rs397507531 rs121918463 rs28933386 rs121918455 rs201787206 rs121918467 rs121918468 rs121918469 rs121918457 rs397507539 rs397507542 rs397507541 rs397507543 rs121918458 rs397507546 rs397507545 rs397507547 rs397509345 rs397507549 rs121918470 rs397516797 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=PTP2Ci; IsoId=Q06124-1; Sequence=Displayed; Name=2; Synonyms=PTP2C; IsoId=Q06124-2; Sequence=VSP_016672; Name=3; IsoId=Q06124-3; Sequence=VSP_016672, VSP_016673, VSP_016674; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26742426}. Nucleus {ECO:0000269|PubMed:26742426}.


uniprotID: Q99952
geneSymbol: PTPN18
reactome: R-HSA-8863795;R-HSA-9008059;
pdb: 2OC3;4GFU;4GFV;4NND;
name: Tyrosine-protein phosphatase non-receptor type 18 (EC 3.1.3.48) (Brain-derived phosphatase)
length: 460
go: ENSG00000072135;
snps: rs3739124
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein tyrosine phosphatase activity [GO:0004725]; blastocyst formation [GO:0001825]; cellular response to cytokine stimulus [GO:0071345]; ERBB2 signaling pathway [GO:0038128]; negative regulation of ERBB signaling pathway [GO:1901185]; protein dephosphorylation [GO:0006470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99952-1; Sequence=Displayed; Name=2; IsoId=Q99952-2; Sequence=VSP_043073; Note=No experimental confirmation available.; 


uniprotID: P17706
geneSymbol: PTPN2
reactome: R-HSA-6807004;R-HSA-877312;R-HSA-9008059;
pdb: 1L8K;
length: 415
go: ENSG00000175354;
name:
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; integrin binding [GO:0005178]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; STAT family protein binding [GO:0097677]; syntaxin binding [GO:0019905]; B cell differentiation [GO:0030183]; cellular response to cytokine stimulus [GO:0071345]; erythrocyte differentiation [GO:0030218]; glucose homeostasis [GO:0042593]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chemotaxis [GO:0050922]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of inflammatory response [GO:0050728]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of interferon-gamma-mediated signaling pathway [GO:0060336]; negative regulation of interleukin-2-mediated signaling pathway [GO:1902206]; negative regulation of interleukin-4-mediated signaling pathway [GO:1902215]; negative regulation of interleukin-6-mediated signaling pathway [GO:0070104]; negative regulation of lipid storage [GO:0010888]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of macrophage differentiation [GO:0045650]; negative regulation of platelet-derived growth factor receptor-beta signaling pathway [GO:2000587]; negative regulation of positive thymic T cell selection [GO:1902233]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of T cell receptor signaling pathway [GO:0050860]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; negative regulation of type I interferon-mediated signaling pathway [GO:0060339]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; positive regulation of gluconeogenesis [GO:0045722]; positive regulation of PERK-mediated unfolded protein response [GO:1903899]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of interferon-gamma-mediated signaling pathway [GO:0060334]; T cell differentiation [GO:0030217]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PTPB, p48TC, TC48, TC-PTPb; IsoId=P17706-1; Sequence=Displayed; Note=Minor isoform.; Name=2; Synonyms=PTPA, p45TC, TC45, TC-PTPa; IsoId=P17706-2; Sequence=VSP_005125; Note=Major isoform. Contains a nuclear location signal at positions 377-381 (Ref.8) and an autoinhibitory region acting through intramolecular interactions is found at positions 353-387. {ECO:0000269|PubMed:15030318, ECO:0000305|PubMed:7593185}; Name=3; IsoId=P17706-3; Sequence=VSP_043383, VSP_005125; Note=No experimental confirmation available.; Name=4; IsoId=P17706-4; Sequence=VSP_054821, VSP_005125; Note=No experimental confirmation available. Gene prediction based on cDNA data.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum {ECO:0000269|PubMed:7593185}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:7593185}. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269|PubMed:7593185}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:9488479}.


uniprotID: P54829
geneSymbol: PTPN5
reactome: R-HSA-9008059;
pdb: 2BIJ;2BV5;2CJZ;5OVR;5OVX;5OW1;6H8R;
length: 565
go: ENSG00000110786;
snps: rs4757707 rs11024773
name:
Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine phosphatase activity [GO:0004725]; cellular response to cytokine stimulus [GO:0071345]; protein dephosphorylation [GO:0006470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=STEP61; IsoId=P54829-1; Sequence=Displayed; Name=2; IsoId=P54829-2; Sequence=VSP_042654; Note=No experimental confirmation available.; Name=3; IsoId=P54829-3; Sequence=VSP_054561; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: P21246
geneSymbol: PTN
pdb: 2N6F;
length: 168
go: ENSG00000105894;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1733956, ECO:0000269|PubMed:8241100}.
name:
Pleiotrophin (PTN) (Heparin-binding brain mitogen) (HBBM) (Heparin-binding growth factor 8) (HBGF-8) (Heparin-binding growth-associated molecule) (HB-GAM) (Heparin-binding neurite outgrowth-promoting factor 1) (HBNF-1) (Osteoblast-specific factor 1) (OSF-1)

sequence:
MQAQQYQQQRRKFAAAFLAFIFILAAVDTAEAGKKEKPEKKVKKSDCGEWQWSVCVPTSGDCGLGTREGTRTGAECKQTMKTQRCKIPCNWKKQFGAECKYQFQAWGECDLNTALKTRTGSLKRALHNAECQKTVTISKPCGKLTKPKPQAESKKKKKEGKKQEKMLD

opentargets:
basement membrane [GO:0005604]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; perinuclear region of cytoplasm [GO:0048471]; postsynapse [GO:0098794]; presynapse [GO:0098793]; protein-containing complex [GO:0032991]; chondroitin sulfate binding [GO:0035374]; chondroitin sulfate proteoglycan binding [GO:0035373]; growth factor activity [GO:0008083]; heparan sulfate binding [GO:1904399]; heparin binding [GO:0008201]; protein kinase binding [GO:0019901]; protein phosphatase inhibitor activity [GO:0004864]; vascular endothelial growth factor binding [GO:0038085]; bone mineralization [GO:0030282]; cellular response to hypoxia [GO:0071456]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to UV [GO:0034644]; cellular response to vitamin D [GO:0071305]; cerebellum development [GO:0021549]; endothelial cell differentiation [GO:0045446]; estrous cycle [GO:0044849]; heart development [GO:0007507]; learning [GO:0007612]; liver development [GO:0001889]; long-term synaptic potentiation [GO:0060291]; lung development [GO:0030324]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of membrane potential [GO:0045837]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of neuromuscular junction development [GO:1904397]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of neuron projection development [GO:0010976]; positive regulation of skeletal muscle acetylcholine-gated channel clustering [GO:1904395]; regulation of cell shape [GO:0008360]; response to activity [GO:0014823]; response to ciliary neurotrophic factor [GO:1904391]; response to estradiol [GO:0032355]; response to kainic acid [GO:1904373]; response to nerve growth factor [GO:1990089]; response to progesterone [GO:0032570]; retinal rod cell differentiation [GO:0060221]; rod bipolar cell differentiation [GO:1904389]; spinal cord development [GO:0021510]; thalamus development [GO:0021794]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]


uniprotID: Q86YD1
geneSymbol: PTOV1
length: 416
go: ENSG00000104960;
opentargets: nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]
name:
Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86YD1-1; Sequence=Displayed; Name=2; IsoId=Q86YD1-2; Sequence=VSP_028154, VSP_028155, VSP_028156; Name=3; IsoId=Q86YD1-3; Sequence=VSP_028153; 

location:
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocates from the cytoplasm to the nucleus at the onset of S-phase. Also localizes to lipid rafts.


uniprotID: Q9UHJ9
geneSymbol: PGAP2
name: Post-GPI attachment to proteins factor 2 (FGF receptor-activating protein 1)
length: 254
go: ENSG00000148985;
snps: rs773359554 rs879255232 rs879255233 rs780188037 rs774843232
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; protein transporter activity [GO:0008565]; GPI anchor biosynthetic process [GO:0006506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=2; IsoId=Q9UHJ9-1; Sequence=Displayed; Name=1; IsoId=Q9UHJ9-2; Sequence=VSP_032550; Note=This isoform is predicted to contain an additional transmembrane domain at position 85-105. If this domain exists, the topology of the protein would be modified, possibly challenging the GPI-anchor remodeling function of the protein.; Name=3; IsoId=Q9UHJ9-3; Sequence=VSP_032551; Name=4; IsoId=Q9UHJ9-4; Sequence=VSP_045984, VSP_045985; Note=No experimental confirmation available.; Name=5; IsoId=Q9UHJ9-5; Sequence=VSP_053800, VSP_032551; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q96FM1
geneSymbol: PGAP3
length: 320
go: ENSG00000161395;
snps: rs587777251 rs371549948 rs587777252
name:
Post-GPI attachment to proteins factor 3 (COS16 homolog) (hCOS16) (Gene coamplified with ERBB2 protein) (PER1-like domain-containing protein 1)

sequence:

opentargets:
Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intrinsic component of endoplasmic reticulum membrane [GO:0031227]; hydrolase activity, acting on ester bonds [GO:0016788]; GPI anchor biosynthetic process [GO:0006506]; GPI anchor metabolic process [GO:0006505]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96FM1-1; Sequence=Displayed; Name=2; IsoId=Q96FM1-2; Sequence=VSP_034158; Note=No experimental confirmation available.; Name=3; IsoId=Q96FM1-3; Sequence=VSP_057229; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:12460457}; Multi-pass membrane protein {ECO:0000305|PubMed:12460457}. Note=Mainly localizes to Golgi apparatus. {ECO:0000305}.


uniprotID: Q96JS3
geneSymbol: PGBD1
name: PiggyBac transposable element-derived protein 1 (Cerebral protein 4)
length: 809
go: ENSG00000137338;
snps: rs3800324 rs3800324 rs3800325 rs3800326 rs33932084 rs16893917 rs1997660 rs6456811
sequence:

opentargets:
membrane [GO:0016020]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; scavenger receptor activity [GO:0005044]


uniprotID: P98160
geneSymbol: HSPG2
pdb: 3SH4;3SH5;
length: 4391
go: ENSG00000142798;
drug: DB00039;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
reactome:
R-HSA-1474228;R-HSA-1971475;R-HSA-2022928;R-HSA-2024096;R-HSA-216083;R-HSA-3000157;R-HSA-3000171;R-HSA-3000178;R-HSA-3560783;R-HSA-3560801;R-HSA-3656237;R-HSA-3656253;R-HSA-4420332;R-HSA-975634;R-HSA-977225;

name:
Basement membrane-specific heparan sulfate proteoglycan core protein (HSPG) (Perlecan) (PLC) [Cleaved into: Endorepellin; LG3 peptide]

sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; plasma membrane protein complex [GO:0098797]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; integrin binding [GO:0005178]; low-density lipoprotein particle receptor binding [GO:0050750]; protein C-terminus binding [GO:0008022]; angiogenesis [GO:0001525]; brain development [GO:0007420]; cardiovascular system development [GO:0072358]; cell differentiation [GO:0030154]; cellular protein metabolic process [GO:0044267]; extracellular matrix organization [GO:0030198]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; inflammatory response [GO:0006954]; lipid metabolic process [GO:0006629]; negative regulation of amyloid fibril formation [GO:1905907]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell death [GO:0060548]; receptor-mediated endocytosis [GO:0006898]; retinoid metabolic process [GO:0001523]

snps:
rs1869780 rs17460381 rs1874792 rs989994 rs2229481 rs10917058 rs897471 rs137853248 rs2229483 rs2229474 rs2229475 rs2229489 rs2229490 rs2229491 rs2228349 rs2291827 rs2270699 rs2229493 rs17459097 rs3736360 


uniprotID: Q96GW7
geneSymbol: BCAN
length: 911
go: ENSG00000132692;
snps: rs12065791 rs1056695
reactome:
R-HSA-1474228;R-HSA-1971475;R-HSA-2022870;R-HSA-2022923;R-HSA-2024101;R-HSA-3000178;R-HSA-3560783;R-HSA-3560801;R-HSA-3595172;R-HSA-3595174;R-HSA-3595177;R-HSA-4420332;

name:
Brevican core protein (Brain-enriched hyaluronan-binding protein) (BEHAB) (Chondroitin sulfate proteoglycan 7)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; carbohydrate binding [GO:0030246]; hyaluronic acid binding [GO:0005540]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; chondroitin sulfate biosynthetic process [GO:0030206]; chondroitin sulfate catabolic process [GO:0030207]; dermatan sulfate biosynthetic process [GO:0030208]; extracellular matrix organization [GO:0030198]; hippocampus development [GO:0021766]; synapse maturation [GO:0060074]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GW7-1; Sequence=Displayed; Name=2; IsoId=Q96GW7-2; Sequence=VSP_011184, VSP_011185; 

location:
SUBCELLULAR LOCATION: Isoform 1: Secreted, extracellular space, extracellular matrix.; SUBCELLULAR LOCATION: Isoform 2: Membrane; Lipid-anchor, GPI-anchor.


uniprotID: Q15257
geneSymbol: PTPA
pdb: 2G62;2HV6;2HV7;2IXM;4LAC;4NY3;
length: 358
go: ENSG00000119383;
snps: rs17481693 rs4836639 rs2480452
name:
Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')

sequence:

opentargets:
calcium channel complex [GO:0034704]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein phosphatase type 2A complex [GO:0000159]; ATP binding [GO:0005524]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; protein phosphatase regulator activity [GO:0019888]; protein tyrosine phosphatase activator activity [GO:0008160]; signaling receptor binding [GO:0005102]; mitotic spindle organization [GO:0007052]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of protein dephosphorylation [GO:0035308]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein dephosphorylation [GO:0035307]; regulation of phosphoprotein phosphatase activity [GO:0043666]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=2; Synonyms=Beta; IsoId=Q15257-1; Sequence=Displayed; Name=1; Synonyms=Alpha; IsoId=Q15257-2; Sequence=VSP_005123; Name=3; Synonyms=Delta; IsoId=Q15257-3; Sequence=VSP_005122; Name=4; Synonyms=Epsilon; IsoId=Q15257-4; Sequence=VSP_005124; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17333320}. Nucleus {ECO:0000269|PubMed:17333320}.


uniprotID: P09619
geneSymbol: PDGFRB
reactome: R-HSA-1257604;R-HSA-186763;R-HSA-186797;R-HSA-2219530;R-HSA-5673001;R-HSA-6811558;
pdb: 1GQ5;1H9O;1LWP;1SHA;2IUI;2L6W;2PLD;2PLE;3MJG;
length: 1106
go: ENSG00000113721;
drug: DB00102;DB01254;DB00619;DB06589;DB08896;DB00398;DB01268;DB05146;DB05014;
name:
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; intrinsic component of plasma membrane [GO:0031226]; lysosomal lumen [GO:0043202]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; phosphatidylinositol 3-kinase binding [GO:0043548]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; platelet-derived growth factor-activated receptor activity [GO:0005017]; protein kinase binding [GO:0019901]; protein tyrosine kinase activity [GO:0004713]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; signaling receptor binding [GO:0005102]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; vascular endothelial growth factor binding [GO:0038085]; aging [GO:0007568]; aorta morphogenesis [GO:0035909]; cardiac myofibril assembly [GO:0055003]; cell chemotaxis [GO:0060326]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cell migration involved in coronary angiogenesis [GO:0060981]; cell migration involved in vasculogenesis [GO:0035441]; glycosaminoglycan biosynthetic process [GO:0006024]; inner ear development [GO:0048839]; lung growth [GO:0060437]; male gonad development [GO:0008584]; MAPK cascade [GO:0000165]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric glomerular capillary formation [GO:0072277]; metanephric glomerular mesangial cell proliferation involved in metanephros development [GO:0072262]; metanephric mesenchymal cell migration [GO:0035789]; metanephric mesenchyme development [GO:0072075]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine phosphorylation [GO:0018108]; phosphatidylinositol metabolic process [GO:0046488]; phosphatidylinositol-mediated signaling [GO:0048015]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of chemotaxis [GO:0050921]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of hepatic stellate cell activation [GO:2000491]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; protein autophosphorylation [GO:0046777]; regulation of actin cytoskeleton organization [GO:0032956]; response to estradiol [GO:0032355]; response to estrogen [GO:0043627]; response to fluid shear stress [GO:0034405]; response to hydrogen peroxide [GO:0042542]; response to hyperoxia [GO:0055093]; response to retinoic acid [GO:0032526]; retina vasculature development in camera-type eye [GO:0061298]; signal transduction [GO:0007165]; smooth muscle cell chemotaxis [GO:0071670]; wound healing [GO:0042060]

snps:
rs17110944 rs17853027 rs34586048 rs2229558 rs41287110 rs367543286 rs863224946 rs397509381 rs144050370 rs35322465 rs397509382 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P09619-1; Sequence=Displayed; Name=2; IsoId=P09619-2; Sequence=VSP_056008, VSP_056009; 

location:
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.


uniprotID: Q32M88
geneSymbol: PGGHG
name: Protein-glucosylgalactosylhydroxylysine glucosidase (EC 3.2.1.107) (Acid trehalase-like protein 1)
length: 737
go: ENSG00000142102;
sequence:

opentargets:
cell wall [GO:0005618]; cytosol [GO:0005829]; alpha,alpha-trehalase activity [GO:0004555]; protein-glucosylgalactosylhydroxylysine glucosidase activity [GO:0047402]; carbohydrate metabolic process [GO:0005975]; trehalose catabolic process [GO:0005993]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q32M88-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q32M88-2; Sequence=VSP_032895, VSP_032896; 


uniprotID: P18433
geneSymbol: PTPRA
reactome: R-HSA-375165;R-HSA-5673001;
length: 802
go: ENSG00000132670;
snps: rs1178027
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; integral component of synaptic membrane [GO:0099699]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; Schaffer collateral - CA1 synapse [GO:0098685]; protein tyrosine phosphatase activity [GO:0004725]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; axon guidance [GO:0007411]; insulin receptor signaling pathway [GO:0008286]; MAPK cascade [GO:0000165]; modulation of chemical synaptic transmission [GO:0050804]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P18433-5; Sequence=Displayed; Name=2; IsoId=P18433-6; Sequence=VSP_059405; 


uniprotID: P23469
geneSymbol: PTPRE
pdb: 2JJD;
length: 700
go: ENSG00000132334;
drug: DB00630;
name:
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; negative regulation of insulin receptor signaling pathway [GO:0046627]; protein dephosphorylation [GO:0006470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative initiation; Named isoforms=3;  Name=1; Synonyms=PTPeM, RPTPe, tm-PTPe; IsoId=P23469-1; Sequence=Displayed; Note=Produced by alternative promoter usage.; Name=2; Synonyms=PTPeC, cyt-PTPe; IsoId=P23469-2; Sequence=VSP_007778; Note=Produced by alternative promoter usage.; Name=3; Synonyms=p67; IsoId=P23469-3; Sequence=VSP_038490; Note=Produced by alternative initiation at Met-86 of isoform 1.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.


uniprotID: P10586
geneSymbol: PTPRF
reactome: R-HSA-388844;R-HSA-8849932;
pdb: 1LAR;2DJU;2DN7;2EDX;2EDY;2YD5;2YD8;4N5U;
name: Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)
length: 1907
go: ENSG00000142949;
snps: rs1065775 rs3748796 rs3748800
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; chondroitin sulfate proteoglycan binding [GO:0035373]; heparin binding [GO:0008201]; protein tyrosine phosphatase activity [GO:0004725]; protein-containing complex binding [GO:0044877]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; negative regulation of receptor binding [GO:1900121]; neuron projection regeneration [GO:0031102]; peptidyl-tyrosine dephosphorylation [GO:0035335]; regulation of axon regeneration [GO:0048679]; synaptic membrane adhesion [GO:0099560]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P10586-1; Sequence=Displayed; Name=2; IsoId=P10586-2; Sequence=VSP_036617; 


uniprotID: P23470
geneSymbol: PTPRG
pdb: 2H4V;2HY3;2NLK;2PBN;3JXH;3QCB;3QCC;3QCD;3QCE;3QCF;3QCG;3QCH;3QCI;3QCJ;3QCK;3QCL;3QCM;3QCN;5E5R;
length: 1445
go: ENSG00000144724;
snps: rs62620047 rs2292245 rs9870460
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; brain development [GO:0007420]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of neuron projection development [GO:0010977]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P23470-1; Sequence=Displayed; Name=2; IsoId=P23470-2; Sequence=VSP_024353; Note=No experimental confirmation available.; 


uniprotID: Q15262
geneSymbol: PTPRK
reactome: R-HSA-182971;
pdb: 2C7S;
length: 1439
go: ENSG00000152894;
name:
Receptor-type tyrosine-protein phosphatase kappa (Protein-tyrosine phosphatase kappa) (R-PTP-kappa) (EC 3.1.3.48)

sequence:

opentargets:
adherens junction [GO:0005912]; axon [GO:0030424]; cell junction [GO:0030054]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; leading edge membrane [GO:0031256]; neuronal cell body [GO:0043025]; photoreceptor outer segment [GO:0001750]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; gamma-catenin binding [GO:0045295]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to reactive oxygen species [GO:0034614]; cellular response to UV [GO:0034644]; focal adhesion assembly [GO:0048041]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron projection development [GO:0031175]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q15262-1; Sequence=Displayed; Name=2; IsoId=Q15262-2; Sequence=VSP_024819; Name=3; IsoId=Q15262-3; Sequence=VSP_024819, VSP_042049; Note=No experimental confirmation available.; Name=4; IsoId=Q15262-4; Sequence=VSP_024819, VSP_054480, VSP_042049; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.


uniprotID: Q16849
geneSymbol: PTPRN
pdb: 2I1Y;2QT7;3N01;3N4W;3NG8;3NP5;
length: 979
go: ENSG00000054356;
snps: rs35314717
name:
Receptor-type tyrosine-protein phosphatase-like N (R-PTP-N) (Islet cell antigen 512) (ICA 512) (Islet cell autoantigen 3) (PTP IA-2) [Cleaved into: ICA512-N-terminal fragment (ICA512-NTF); ICA512-transmembrane fragment (ICA512-TMF); ICA512-cleaved cytosolic fragment (ICA512-CCF)]

sequence:

opentargets:
axon terminus [GO:0043679]; cell junction [GO:0030054]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synapse [GO:0045202]; transport vesicle membrane [GO:0030658]; GTPase binding [GO:0051020]; spectrin binding [GO:0030507]; transcription factor binding [GO:0008134]; ubiquitin-like protein ligase binding [GO:0044389]; cytokine-mediated signaling pathway [GO:0019221]; dense core granule maturation [GO:1990502]; insulin secretion [GO:0030073]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; luteinization [GO:0001553]; peptidyl-tyrosine dephosphorylation [GO:0035335]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type B pancreatic cell proliferation [GO:1904692]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to insulin [GO:0032868]; response to reactive oxygen species [GO:0000302]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q16849-1; Sequence=Displayed; Name=2; IsoId=Q16849-2; Sequence=VSP_043654; Note=No experimental confirmation available.; Name=3; IsoId=Q16849-3; Sequence=VSP_045867; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q63259}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:25561468}; Single-pass type I membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q63259}. Cell projection, axon {ECO:0000250|UniProtKB:Q63259}. Cell junction, synapse {ECO:0000250|UniProtKB:Q63259}. Cell membrane {ECO:0000269|PubMed:10457160}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Endosome {ECO:0000250|UniProtKB:Q63259}. Note=Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin-containing secretory granules (PubMed:25561468). Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. {ECO:0000250|UniProtKB:Q63259, ECO:0000269|PubMed:25561468}.; SUBCELLULAR LOCATION: ICA512-transmembrane fragment: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q63259}.; SUBCELLULAR LOCATION: ICA512-cleaved cytosolic fragment: Nucleus {ECO:0000269|PubMed:15596545}.


uniprotID: Q16827
geneSymbol: PTPRO
reactome: R-HSA-9034015;
pdb: 2G59;2GJT;
length: 1216
go: ENSG00000151490;
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; axon [GO:0030424]; dendritic spine [GO:0043197]; extracellular exosome [GO:0070062]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; growth cone [GO:0030426]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic density membrane [GO:0099061]; lamellipodium [GO:0030027]; lateral plasma membrane [GO:0016328]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; phosphatase activity [GO:0016791]; protein homodimerization activity [GO:0042803]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; Wnt-protein binding [GO:0017147]; axon guidance [GO:0007411]; cell morphogenesis [GO:0000902]; glomerular visceral epithelial cell differentiation [GO:0072112]; glomerulus development [GO:0032835]; lamellipodium assembly [GO:0030032]; monocyte chemotaxis [GO:0002548]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of glomerular filtration [GO:0003105]; negative regulation of neuron projection development [GO:0010977]; negative regulation of retinal ganglion cell axon guidance [GO:0090260]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of glomerular filtration [GO:0003093]; regulation of synapse organization [GO:0050807]; slit diaphragm assembly [GO:0036060]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q16827-1; Sequence=Displayed; Name=2; IsoId=Q16827-2; Sequence=VSP_035586; Name=3; Synonyms=PTPROt; IsoId=Q16827-3; Sequence=VSP_043136; Note=Predominantly expressed in B-lymphoid tissues.; Name=4; IsoId=Q16827-4; Sequence=VSP_043136, VSP_035586; Name=5; IsoId=Q16827-5; Sequence=VSP_054481, VSP_054482; Note=No experimental confirmation available.; 


uniprotID: Q9UMZ3
geneSymbol: PTPRQ
pdb: 4IKC;
length: 2332
snps: rs61729287 rs12316867 rs6539524 rs7975340 rs17713202 rs7963963 rs1163042
name:
Phosphatidylinositol phosphatase PTPRQ (EC 3.1.3.-) (Receptor-type tyrosine-protein phosphatase Q) (PTP-RQ) (R-PTP-Q) (EC 3.1.3.48)

sequence:

opentargets:
integral component of membrane [GO:0016021]; protein tyrosine phosphatase activity [GO:0004725]; regulation of fat cell differentiation [GO:0045598]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12837292}; Single-pass type I membrane protein {ECO:0000269|PubMed:12837292}.


uniprotID: Q03393
geneSymbol: PTS
reactome: R-HSA-1474151;
pdb: 3I2B;
name: 6-pyruvoyl tetrahydrobiopterin synthase (PTP synthase) (PTPS) (EC 4.2.3.12)
length: 145
go: ENSG00000150787;
drug: DB03886;
sequence:
MSTEGGGRRCQAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYETDNNIVVYKGE

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; 6-pyruvoyltetrahydropterin synthase activity [GO:0003874]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; cellular amino acid metabolic process [GO:0006520]; central nervous system development [GO:0007417]; cofactor metabolic process [GO:0051186]; tetrahydrobiopterin biosynthetic process [GO:0006729]

snps:
rs104894274 rs104894273 rs1328320990 rs1449216377 rs104894278 rs104894275 rs104894277 rs370340361 rs765406631 rs104894276 rs104894280 rs750455879 rs200712908 rs104894279 rs150726932 rs1040441824 


uniprotID: Q96G03
geneSymbol: PGM2
reactome: R-HSA-3322077;R-HSA-6798695;R-HSA-70221;R-HSA-70370;R-HSA-71336;
length: 612
go: ENSG00000169299;
snps: rs17856324 rs10001580
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Phosphoglucomutase-2 (PGM 2) (EC 5.4.2.2) (Glucose phosphomutase 2) (Phosphodeoxyribomutase) (Phosphopentomutase) (EC 5.4.2.7)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; phosphopentomutase activity [GO:0008973]; deoxyribose phosphate catabolic process [GO:0046386]; galactose catabolic process [GO:0019388]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]; glycogen catabolic process [GO:0005980]; neutrophil degranulation [GO:0043312]; pentose-phosphate shunt [GO:0006098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96G03-1; Sequence=Displayed; Name=2; IsoId=Q96G03-2; Sequence=VSP_056221, VSP_056222, VSP_056223, VSP_056224; Note=No experimental confirmation available.; 


uniprotID: Q96P68
geneSymbol: OXGR1
reactome: R-HSA-373076;R-HSA-418594;
length: 337
go: ENSG00000165621;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
2-oxoglutarate receptor 1 (Alpha-ketoglutarate receptor 1) (G-protein coupled receptor 80) (G-protein coupled receptor 99) (P2Y purinoceptor 15) (P2Y15) (P2Y-like GPCR) (P2Y-like nucleotide receptor)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]


uniprotID: O14753
geneSymbol: OVOL1
name: Putative transcription factor Ovo-like 1 (hOvo1)
length: 267
go: ENSG00000172818;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; epidermal cell differentiation [GO:0009913]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; kidney development [GO:0001822]; mesoderm development [GO:0007498]; negative regulation of meiotic cell cycle phase transition [GO:1901994]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of transcription, DNA-templated [GO:0045892]; skin development [GO:0043588]; spermatogenesis [GO:0007283]


uniprotID: O00110
geneSymbol: OVOL3
name: Putative transcription factor ovo-like protein 3
length: 214
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]


uniprotID: A8CG34
geneSymbol: POM121C
length: 1229
go: ENSG00000272391;
snps: rs427206 rs365436
reactome:
R-HSA-1169408;R-HSA-159227;R-HSA-159230;R-HSA-159231;R-HSA-159236;R-HSA-165054;R-HSA-168271;R-HSA-168276;R-HSA-168325;R-HSA-168333;R-HSA-170822;R-HSA-180746;R-HSA-180910;R-HSA-191859;R-HSA-3108214;R-HSA-3232142;R-HSA-3301854;R-HSA-3371453;R-HSA-4085377;R-HSA-4551638;R-HSA-4570464;R-HSA-4615885;R-HSA-5578749;R-HSA-6784531;

name:
Nuclear envelope pore membrane protein POM 121C (Nuclear pore membrane protein 121-2) (POM121-2) (Pore membrane protein of 121 kDa C)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear localization sequence binding [GO:0008139]; structural constituent of nuclear pore [GO:0017056]; mRNA export from nucleus [GO:0006406]; protein import into nucleus [GO:0006606]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A8CG34-1; Sequence=Displayed; Name=2; IsoId=A8CG34-2; Sequence=VSP_040759; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:17900573}. Nucleus membrane {ECO:0000269|PubMed:17900573}; Single-pass membrane protein {ECO:0000269|PubMed:17900573}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. {ECO:0000250}.


uniprotID: Q96DU9
geneSymbol: PABPC5
name: Polyadenylate-binding protein 5 (PABP-5) (Poly(A)-binding protein 5)
length: 382
go: ENSG00000174740;
snps: rs7050077
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=1; IsoId=Q96DU9-1; Sequence=Displayed; Name=2; IsoId=Q96DU9-2; Sequence=VSP_047456; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Mitochondrion matrix {ECO:0000269|PubMed:23275553}. Note=Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.


uniprotID: P0CB38
geneSymbol: PABPC4L
name: Polyadenylate-binding protein 4-like (PABP-4-like) (Poly(A)-binding protein 4-like)
length: 370
go: ENSG00000254535;
snps: rs10009368 rs6830036 rs11099273
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]


uniprotID: Q7Z2X7
geneSymbol: PAGE2
name: P antigen family member 2 (PAGE-2) (G antigen family C 2) (Prostate-associated gene 2 protein)
length: 111
go: ENSG00000234068;
snps: rs1845444
sequence:
MSELLRARSQSSERGNDQESSQPVGSVIVQEPTEEKRQEEEPPTDNQGIAPSGEIENQAVPAFQGPDMEAFQQELALLKIEDEPGDGPDVREGIMPTFDLTKVLEAGDAQP


uniprotID: Q86VP3
geneSymbol: PACS2
name: Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)
length: 889
go: ENSG00000179364;
snps: rs8010888 rs4076933
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; mitochondrion [GO:0005739]; ion channel binding [GO:0044325]; apoptotic process [GO:0006915]; autophagosome assembly [GO:0000045]; protein localization to phagophore assembly site [GO:0034497]; protein localization to plasma membrane [GO:0072659]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86VP3-1; Sequence=Displayed; Name=2; IsoId=Q86VP3-2; Sequence=VSP_021409, VSP_021410; Note=No experimental confirmation available.; Name=3; IsoId=Q86VP3-3; Sequence=VSP_030293, VSP_030294; Note=No experimental confirmation available. Incomplete sequence.; Name=4; IsoId=Q86VP3-4; Sequence=VSP_053815, VSP_030294; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15692567}. Mitochondrion {ECO:0000269|PubMed:15692567}.


uniprotID: Q9ULE6
geneSymbol: PALD1
name: Paladin
length: 856
go: ENSG00000107719;
snps: rs2275060 rs3740447 rs10999406
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22354871}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine phosphatase activity [GO:0004725]


uniprotID: Q8NC51
geneSymbol: SERBP1
pdb: 4V6X;
length: 408
go: ENSG00000142864;
name:
Plasminogen activator inhibitor 1 RNA-binding protein (PAI1 RNA-binding protein 1) (PAI-RBP1) (SERPINE1 mRNA-binding protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; regulation of apoptotic process [GO:0042981]; regulation of mRNA stability [GO:0043488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8NC51-1; Sequence=Displayed; Name=2; IsoId=Q8NC51-2; Sequence=VSP_011630; Note=May be due to a competing acceptor splice site.; Name=3; IsoId=Q8NC51-3; Sequence=VSP_011631; Note=May be due to a competing acceptor splice site. {ECO:0000244|PubMed:17081983, ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:28112733}; Name=4; IsoId=Q8NC51-4; Sequence=VSP_011630, VSP_011631; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12505151}. Nucleus {ECO:0000269|PubMed:12505151}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12505151}. Note=Also found in perinuclear regions.


uniprotID: Q96RD6
geneSymbol: PANX2
reactome: R-HSA-112303;
name: Pannexin-2
length: 677
go: ENSG00000073150;
snps: rs941735789
sequence:

opentargets:
cytoplasm [GO:0005737]; gap junction [GO:0005921]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; gap junction hemi-channel activity [GO:0055077]; cation transport [GO:0006812]; cell-cell signaling [GO:0007267]; positive regulation of interleukin-1 secretion [GO:0050716]; protein hexamerization [GO:0034214]; response to ischemia [GO:0002931]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=Q96RD6-3; Sequence=Displayed; Name=1; IsoId=Q96RD6-1; Sequence=VSP_002677; Name=2; IsoId=Q96RD6-2; Sequence=VSP_039092, VSP_002677; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction.


uniprotID: Q8TE04
geneSymbol: PANK1
reactome: R-HSA-196783;
pdb: 2I7N;3SMP;
name: Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1)
length: 598
go: ENSG00000152782;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14523052}.
sequence:

opentargets:
cell periphery [GO:0071944]; clathrin coat [GO:0030118]; cytosol [GO:0005829]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; acetyl-CoA binding [GO:1905502]; ATP binding [GO:0005524]; pantothenate kinase activity [GO:0004594]; protein homodimerization activity [GO:0042803]; coenzyme A biosynthetic process [GO:0015937]; coenzyme biosynthetic process [GO:0009108]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PanK1-alpha, PANK1a; IsoId=Q8TE04-1; Sequence=Displayed; Name=2; Synonyms=PANK1a, PanK1-beta; IsoId=Q8TE04-2; Sequence=VSP_004520; Name=3; Synonyms=PANK1b; IsoId=Q8TE04-3; Sequence=VSP_004520, VSP_004521; Name=4; Synonyms=PanK1-gamma; IsoId=Q8TE04-4; Sequence=VSP_012823, VSP_012824; 


uniprotID: Q6QHF9
geneSymbol: PAOX
reactome: R-HSA-141334;R-HSA-351200;R-HSA-9033241;
name: Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (EC 1.5.3.13) (Polyamine oxidase)
length: 649
go: ENSG00000148832;
location: SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; peroxisomal matrix [GO:0005782]; N(1),N(12)-diacetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052899]; N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052904]; N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity [GO:0052903]; oxidoreductase activity [GO:0016491]; polyamine oxidase activity [GO:0046592]; signaling receptor binding [GO:0005102]; spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity [GO:0052902]; spermine:oxygen oxidoreductase (spermidine-forming) activity [GO:0052901]; polyamine biosynthetic process [GO:0006596]; polyamine catabolic process [GO:0006598]; positive regulation of spermidine biosynthetic process [GO:1901307]; protein targeting to peroxisome [GO:0006625]; putrescine biosynthetic process [GO:0009446]; putrescine catabolic process [GO:0009447]; spermidine catabolic process [GO:0046203]; spermine catabolic process [GO:0046208]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=11;  Name=9; IsoId=Q6QHF9-1; Sequence=Displayed; Name=1; IsoId=Q6QHF9-2; Sequence=VSP_011249; Name=3; Synonyms=7; IsoId=Q6QHF9-6; Sequence=VSP_011250, VSP_011251; Name=4; Synonyms=2; IsoId=Q6QHF9-5; Sequence=VSP_011249, VSP_011255, VSP_011257; Name=5; IsoId=Q6QHF9-4; Sequence=VSP_011249, VSP_011258; Name=6; IsoId=Q6QHF9-8; Sequence=VSP_011248, VSP_011256; Name=8; IsoId=Q6QHF9-3; Sequence=VSP_011249, VSP_011254; Name=10; IsoId=Q6QHF9-7; Sequence=VSP_011252; Name=11; IsoId=Q6QHF9-9; Sequence=VSP_011247, VSP_011253; Name=12; IsoId=Q6QHF9-10; Sequence=VSP_011259, VSP_011260; Name=13; IsoId=Q6QHF9-11; Sequence=VSP_011261, VSP_011262; 


uniprotID: Q5JQF8
geneSymbol: PABPC1L2A; PABPC1L2B
name: Polyadenylate-binding protein 1-like 2 (RNA-binding motif protein 32) (RNA-binding protein 32)
length: 200
go: ENSG00000184388;ENSG00000186288;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]


uniprotID: Q9NRJ5
geneSymbol: PAPOLB
length: 636
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Poly(A) polymerase beta (PAP-beta) (EC 2.7.7.19) (Polynucleotide adenylyltransferase beta) (Testis-specific poly(A) polymerase)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; mRNA polyadenylation [GO:0006378]


uniprotID: Q13219
geneSymbol: PAPPA
reactome: R-HSA-381426;
length: 1627
go: ENSG00000182752;
snps: rs417012 rs445159 rs117124330 rs7020782
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10077652}.
name:
Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; cellular protein metabolic process [GO:0044267]; female pregnancy [GO:0007565]; response to follicle-stimulating hormone [GO:0032354]; response to glucocorticoid [GO:0051384]


uniprotID: Q9BXP8
geneSymbol: PAPPA2
reactome: R-HSA-381426;
length: 1791
go: ENSG00000116183;
snps: rs36112782 rs34602579
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
name:
Pappalysin-2 (EC 3.4.24.-) (Pregnancy-associated plasma protein A2) (PAPP-A2) (Pregnancy-associated plasma protein E1) (PAPP-E)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; intracellular [GO:0005622]; metalloendopeptidase activity [GO:0004222]; metallopeptidase activity [GO:0008237]; zinc ion binding [GO:0008270]; bone morphogenesis [GO:0060349]; cellular protein metabolic process [GO:0044267]; proteolysis [GO:0006508]; regulation of cell growth [GO:0001558]; response to salt stress [GO:0009651]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Papp-e(1); IsoId=Q9BXP8-1; Sequence=Displayed; Name=2; Synonyms=Papp-e(2); IsoId=Q9BXP8-2; Sequence=VSP_012194, VSP_012195; 


uniprotID: O43252
geneSymbol: PAPSS1
reactome: R-HSA-174362;R-HSA-2408550;R-HSA-6802952;
pdb: 1X6V;1XJQ;1XNJ;2OFW;2OFX;2PEY;2PEZ;2QJF;
length: 624
go: ENSG00000138801;
drug: DB03708;DB04077;
snps: rs1127008 rs1127014
name:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]

sequence:

opentargets:
cytosol [GO:0005829]; adenylylsulfate kinase activity [GO:0004020]; ATP binding [GO:0005524]; nucleotidyltransferase activity [GO:0016779]; protein homodimerization activity [GO:0042803]; sulfate adenylyltransferase (ATP) activity [GO:0004781]; 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process [GO:0050428]; skeletal system development [GO:0001501]; sulfate assimilation [GO:0000103]


uniprotID: Q9HBI0
geneSymbol: PARVG
name: Gamma-parvin
length: 331
go: ENSG00000138964;
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actin cytoskeleton reorganization [GO:0031532]; cell projection assembly [GO:0030031]; cell-matrix adhesion [GO:0007160]; establishment or maintenance of cell polarity [GO:0007163]; substrate adhesion-dependent cell spreading [GO:0034446]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9HBI0-1; Sequence=Displayed; Name=2; IsoId=Q9HBI0-2; Sequence=VSP_004540, VSP_004541; Note=No experimental confirmation available.; Name=3; IsoId=Q9HBI0-3; Sequence=VSP_012953, VSP_012954; Note=No experimental confirmation available.; Name=4; IsoId=Q9HBI0-4; Sequence=VSP_045145, VSP_045146, VSP_045147; Name=5; IsoId=Q9HBI0-5; Sequence=VSP_045146, VSP_045147; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Constituent of focal adhesions. {ECO:0000250}.


uniprotID: O95453
geneSymbol: PARN
reactome: R-HSA-380994;R-HSA-429947;R-HSA-450604;
pdb: 2A1R;2A1S;3CTR;
length: 639
go: ENSG00000140694;
snps: rs786200999 rs777090017
name:
Poly(A)-specific ribonuclease PARN (EC 3.1.13.4) (Deadenylating nuclease) (Deadenylation nuclease) (Polyadenylate-specific ribonuclease)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; 3'-5'-exoribonuclease activity [GO:0000175]; cation binding [GO:0043169]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; nuclease activity [GO:0004518]; poly(A)-specific ribonuclease activity [GO:0004535]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; box H/ACA snoRNA 3'-end processing [GO:0000495]; female gamete generation [GO:0007292]; miRNA catabolic process [GO:0010587]; ncRNA deadenylation [GO:0110008]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; regulation of mRNA stability [GO:0043488]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; RNA modification [GO:0009451]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; telomerase RNA stabilization [GO:0090669]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O95453-1; Sequence=Displayed; Name=2; IsoId=O95453-2; Sequence=VSP_042846; Note=No experimental confirmation available. Non canonical splice junctions.; Name=3; IsoId=O95453-3; Sequence=VSP_042847; Name=4; IsoId=O95453-4; Sequence=VSP_057269; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9736620}. Cytoplasm {ECO:0000269|PubMed:9736620}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22442037}. Note=Some nuclear fraction is nucleolar.


uniprotID: Q9HBE1
geneSymbol: PATZ1
pdb: 2EPP;2EPQ;2EPR;2EPS;2YT9;
length: 687
go: ENSG00000100105;
snps: rs2240424
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10713105}.
name:
POZ-, AT hook-, and zinc finger-containing protein 1 (BTB/POZ domain zinc finger transcription factor) (Protein kinase A RI subunit alpha-associated protein) (Zinc finger and BTB domain-containing protein 19) (Zinc finger protein 278) (Zinc finger sarcoma gene protein)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; male gonad development [GO:0008584]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; T cell differentiation [GO:0030217]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=C; IsoId=Q9HBE1-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9HBE1-2; Sequence=VSP_008799, VSP_008800; Name=3; Synonyms=A; IsoId=Q9HBE1-3; Sequence=VSP_008801; Name=4; Synonyms=Short; IsoId=Q9HBE1-4; Sequence=VSP_008802, VSP_008800; 


uniprotID: Q9Y6F1
geneSymbol: PARP3
pdb: 2EOC;3C49;3C4H;3CE0;3FHB;4GV0;4GV2;4GV4;4L6Z;4L70;4L7L;4L7N;4L7O;4L7P;4L7R;4L7U;
length: 533
go: ENSG00000041880;
drug: DB09074;DB12332;
snps: rs34224216 rs28547534 rs323870
name:
Poly [ADP-ribose] polymerase 3 (PARP-3) (hPARP-3) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)

sequence:

opentargets:
centriole [GO:0005814]; nucleolus [GO:0005730]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; catalytic activity [GO:0003824]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; protein ADP-ribosylase activity [GO:1990404]; DNA repair [GO:0006281]; double-strand break repair [GO:0006302]; negative regulation of telomerase RNA reverse transcriptase activity [GO:1905662]; positive regulation of DNA ligation [GO:0051106]; protein ADP-ribosylation [GO:0006471]; protein localization to site of double-strand break [GO:1990166]; protein poly-ADP-ribosylation [GO:0070212]; regulation of mitotic spindle organization [GO:0060236]; telomere maintenance [GO:0000723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Short; IsoId=Q9Y6F1-1; Sequence=Displayed; Note=More abundant isoform. {ECO:0000269|PubMed:16924674}; Name=2; Synonyms=Long; IsoId=Q9Y6F1-2; Sequence=VSP_007863; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Core component of the centrosome. Preferentially localized to the daughter centriole throughout the cell cycle. According to PubMed:16924674, it is almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected.


uniprotID: P49023
geneSymbol: PXN
reactome: R-HSA-180292;R-HSA-4420097;R-HSA-445355;R-HSA-446343;R-HSA-446388;R-HSA-8849471;
name: Paxillin
length: 591
go: ENSG00000089159;
snps: rs4767884
pdb:
1KKY;1KL0;1OW6;1OW7;1OW8;2K2R;2O9V;2VZD;2VZG;2VZI;3GM1;3PY7;3RQE;3RQF;3RQG;3U3F;4EDN;4R32;4XGZ;4XH2;5UWH;

sequence:

opentargets:
cell cortex [GO:0005938]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microtubule associated complex [GO:0005875]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; beta-catenin binding [GO:0008013]; integrin binding [GO:0005178]; metal ion binding [GO:0046872]; neuropilin binding [GO:0038191]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; ubiquitin protein ligase binding [GO:0031625]; vinculin binding [GO:0017166]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; cellular response to reactive oxygen species [GO:0034614]; endothelial cell migration [GO:0043542]; growth hormone receptor signaling pathway [GO:0060396]; muscle contraction [GO:0006936]; positive regulation of stress fiber assembly [GO:0051496]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=Beta; IsoId=P49023-1; Sequence=Displayed; Name=Alpha; IsoId=P49023-2; Sequence=VSP_003114; Name=Gamma; IsoId=P49023-3; Sequence=VSP_003115; Name=4; IsoId=P49023-4; Sequence=VSP_040483, VSP_003114; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20489202}. Cell junction, focal adhesion {ECO:0000269|PubMed:20489202, ECO:0000269|PubMed:23128389}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VI36}. Note=Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389). {ECO:0000250, ECO:0000269|PubMed:23128389}.


uniprotID: Q06710
geneSymbol: PAX8
pdb: 2K27;
name: Paired box protein Pax-8
length: 450
go: ENSG00000125618;
snps: rs104893657 rs104893656 rs104893659 rs104893658 rs3188996
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; thyroid-stimulating hormone receptor activity [GO:0004996]; transcription regulatory region DNA binding [GO:0044212]; anatomical structure morphogenesis [GO:0009653]; branching involved in ureteric bud morphogenesis [GO:0001658]; cellular response to gonadotropin stimulus [GO:0071371]; central nervous system development [GO:0007417]; inner ear morphogenesis [GO:0042472]; kidney development [GO:0001822]; mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003337]; mesonephros development [GO:0001823]; metanephric comma-shaped body morphogenesis [GO:0072278]; metanephric distal convoluted tubule development [GO:0072221]; metanephric epithelium development [GO:0072207]; metanephric nephron tubule formation [GO:0072289]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process involved in metanephric collecting duct development [GO:1900215]; negative regulation of apoptotic process involved in metanephric nephron tubule development [GO:1900218]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis [GO:0072305]; negative regulation of mesenchymal cell apoptotic process involved in metanephros development [GO:1900212]; otic vesicle development [GO:0071599]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0072108]; positive regulation of metanephric DCT cell differentiation [GO:2000594]; positive regulation of thyroid hormone generation [GO:2000611]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; pronephric field specification [GO:0039003]; pronephros development [GO:0048793]; regulation of apoptotic process [GO:0042981]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of thyroid-stimulating hormone secretion [GO:2000612]; sulfur compound metabolic process [GO:0006790]; thyroid gland development [GO:0030878]; transcription, DNA-templated [GO:0006351]; urogenital system development [GO:0001655]; ventricular septum development [GO:0003281]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=Pax8a; IsoId=Q06710-1; Sequence=Displayed; Name=2; Synonyms=Pax8b; IsoId=Q06710-2; Sequence=VSP_002372; Name=3; Synonyms=Pax8c; IsoId=Q06710-3; Sequence=VSP_002373; Name=4; Synonyms=Pax8d; IsoId=Q06710-4; Sequence=VSP_002374; Name=5; Synonyms=Pax8e; IsoId=Q06710-5; Sequence=VSP_002375; 


uniprotID: O00408
geneSymbol: PDE2A
reactome: R-HSA-418457;R-HSA-418555;
length: 941
go: ENSG00000186642;
drug: DB07954;DB00201;DB02315;DB05142;DB08811;
snps: rs341047
pdb:
1Z1L;3IBJ;3ITM;3ITU;4C1I;4D08;4D09;4HTX;4HTZ;4JIB;5TZ3;5TZA;5TZC;5TZH;5TZW;5TZX;5TZZ;5U00;5U7D;5U7I;5U7J;5U7K;5U7L;5VP0;5VP1;5XKM;6B96;6B97;6B98;6C7D;6C7E;6C7F;6C7G;6C7I;6C7J;6CYB;6CYC;6CYD;

name:
cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrial outer membrane [GO:0005741]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; calcium channel activity [GO:0005262]; cAMP binding [GO:0030552]; cGMP binding [GO:0030553]; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity [GO:0004118]; drug binding [GO:0008144]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; TPR domain binding [GO:0030911]; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [GO:0007193]; cAMP-mediated signaling [GO:0019933]; cellular response to 2,3,7,8-tetrachlorodibenzodioxine [GO:1904613]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to drug [GO:0035690]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to macrophage colony-stimulating factor stimulus [GO:0036006]; cellular response to mechanical stimulus [GO:0071260]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cGMP catabolic process [GO:0046069]; cGMP-mediated signaling [GO:0019934]; establishment of endothelial barrier [GO:0061028]; G protein-coupled receptor signaling pathway [GO:0007186]; monocyte differentiation [GO:0030224]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of protein import into nucleus, translocation [GO:0033159]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of vascular permeability [GO:0043116]; positive regulation of inflammatory response [GO:0050729]; positive regulation of vascular permeability [GO:0043117]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=PDE2A3; IsoId=O00408-1; Sequence=Displayed; Name=PDE2A1; IsoId=O00408-2; Sequence=VSP_055315; Note=Soluble form.; Name=PDE2A2; IsoId=O00408-3; Sequence=VSP_055316; Note=Contains a transit peptide at positions 1-17.; Name=PDE2A4; IsoId=O00408-4; Sequence=VSP_055317; Name=5; IsoId=O00408-5; Sequence=VSP_055316, VSP_055318; Note=No experimental confirmation available.; Name=6; IsoId=O00408-6; Sequence=VSP_055315, VSP_055319, VSP_055320; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform PDE2A3: Cell membrane {ECO:0000269|PubMed:19632989, ECO:0000269|PubMed:28463107}; Lipid-anchor {ECO:0000269|PubMed:19632989}.; SUBCELLULAR LOCATION: Isoform PDE2A2: Mitochondrion matrix {ECO:0000250|UniProtKB:Q922S4}. Mitochondrion inner membrane {ECO:0000269|PubMed:28463107}. Mitochondrion outer membrane {ECO:0000269|PubMed:28463107}.; SUBCELLULAR LOCATION: Isoform PDE2A1: Cytoplasm {ECO:0000269|PubMed:19632989, ECO:0000269|PubMed:28463107}.; SUBCELLULAR LOCATION: Isoform 5: Mitochondrion {ECO:0000305}.


uniprotID: Q9NP56
geneSymbol: PDE7B
reactome: R-HSA-418555;
pdb: 1LXW;
name: cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.53)
length: 450
go: ENSG00000171408;
drug: DB00201;DB00651;
sequence:

opentargets:
cytosol [GO:0005829]; 3',5'-cyclic-AMP phosphodiesterase activity [GO:0004115]; metal ion binding [GO:0046872]; cAMP catabolic process [GO:0006198]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; signal transduction [GO:0007165]


uniprotID: P35913
geneSymbol: PDE6B
reactome: R-HSA-2485179;R-HSA-2514859;R-HSA-4086398;
name: Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta (GMP-PDE beta) (EC 3.1.4.35)
length: 854
go: ENSG00000133256;
drug: DB00201;
location: SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
sequence:

opentargets:
photoreceptor disc membrane [GO:0097381]; plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; metal ion binding [GO:0046872]; G protein-coupled receptor signaling pathway [GO:0007186]; phototransduction, visible light [GO:0007603]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; retina development in camera-type eye [GO:0060041]; rhodopsin mediated signaling pathway [GO:0016056]; visual perception [GO:0007601]

snps:
rs144590560 rs555600300 rs115775983 rs551545798 rs62295357 rs201584824 rs121918582 rs10902758 rs760766981 rs527236088 rs751859807 rs121918581 rs17849286 rs141563823 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P35913-1; Sequence=Displayed; Name=2; IsoId=P35913-2; Sequence=VSP_036884; Name=3; IsoId=P35913-3; Sequence=VSP_044919; Note=No experimental confirmation available.; 


uniprotID: P51160
geneSymbol: PDE6C
pdb: 3JWQ;3JWR;5E8F;
length: 858
go: ENSG00000095464;
drug: DB00201;
name:
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C)

sequence:

opentargets:
plasma membrane [GO:0005886]; 3',5'-cyclic-GMP phosphodiesterase activity [GO:0047555]; cGMP binding [GO:0030553]; metal ion binding [GO:0046872]; phototransduction, visible light [GO:0007603]; retinal cone cell development [GO:0046549]; visual perception [GO:0007601]

snps:
rs121918537 rs769506319 rs76999928 rs701865 rs121918538 rs121918539 rs267606934 rs12261131 rs267606936 rs79487435 rs148661165 


uniprotID: P01127
geneSymbol: PDGFB
pdb: 1PDG;3MJG;4HQU;4HQX;4QCI;
length: 241
go: ENSG00000100311;
snps: rs17565 rs397515632
location: SUBCELLULAR LOCATION: Secreted. Note=Released by platelets upon wounding.
reactome:
R-HSA-114608;R-HSA-1257604;R-HSA-186763;R-HSA-186797;R-HSA-2219530;R-HSA-3000171;R-HSA-5673001;R-HSA-6811558;

name:
Platelet-derived growth factor subunit B (PDGF subunit B) (PDGF-2) (Platelet-derived growth factor B chain) (Platelet-derived growth factor beta polypeptide) (Proto-oncogene c-Sis) (Becaplermin)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; Golgi membrane [GO:0000139]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; collagen binding [GO:0005518]; growth factor activity [GO:0008083]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; platelet-derived growth factor binding [GO:0048407]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; activation of protein kinase activity [GO:0032147]; activation of protein kinase B activity [GO:0032148]; cell chemotaxis [GO:0060326]; cellular response to growth factor stimulus [GO:0071363]; cellular response to mycophenolic acid [GO:0071506]; embryonic placenta development [GO:0001892]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; interleukin-18-mediated signaling pathway [GO:0035655]; MAPK cascade [GO:0000165]; metanephric glomerular mesangial cell development [GO:0072255]; monocyte chemotaxis [GO:0002548]; negative regulation of gene expression [GO:0010629]; negative regulation of phosphatidylinositol biosynthetic process [GO:0010512]; negative regulation of platelet activation [GO:0010544]; negative regulation of pri-miRNA transcription by RNA polymerase II [GO:1902894]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of vascular smooth muscle cell differentiation [GO:1905064]; paracrine signaling [GO:0038001]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet degranulation [GO:0002576]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of calcium ion import [GO:0090280]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of hyaluronan biosynthetic process [GO:1900127]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of metanephric mesenchymal cell migration [GO:2000591]; positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [GO:0035793]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular smooth muscle cell dedifferentiation [GO:1905176]; positive regulation of vascular smooth muscle cell proliferation [GO:1904707]; protein kinase C signaling [GO:0070528]; protein phosphorylation [GO:0006468]; reactive oxygen species metabolic process [GO:0072593]; response to wounding [GO:0009611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage; Named isoforms=2;  Name=1; IsoId=P01127-1; Sequence=Displayed; Name=2; IsoId=P01127-2; Sequence=VSP_044913; 


uniprotID: Q16342
geneSymbol: PDCD2
length: 344
go: ENSG00000071994;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Programmed cell death protein 2 (Zinc finger MYND domain-containing protein 7) (Zinc finger protein Rp-8)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; positive regulation of apoptotic process [GO:0043065]; positive regulation of hematopoietic stem cell proliferation [GO:1902035]; regulation of hematopoietic progenitor cell differentiation [GO:1901532]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q16342-1; Sequence=Displayed; Name=2; IsoId=Q16342-2; Sequence=VSP_042828, VSP_042829; Name=3; IsoId=Q16342-3; Sequence=VSP_042828; Name=4; IsoId=Q16342-4; Sequence=VSP_055159, VSP_055162; Note=No experimental confirmation available. Gene prediction based on partial EST data.; Name=5; IsoId=Q16342-5; Sequence=VSP_042828, VSP_055160, VSP_055161; Note=No experimental confirmation available. Gene prediction based on partial EST data.; 


uniprotID: O75340
geneSymbol: PDCD6
pdb: 2ZN8;2ZN9;2ZND;2ZNE;2ZRS;2ZRT;3AAJ;3AAK;3WXA;5GQQ;
name: Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2)
length: 191
go: ENSG00000249915;
sequence:
MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV

opentargets:
COPII vesicle coat [GO:0030127]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; molecular adaptor activity [GO:0060090]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein membrane anchor [GO:0043495]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; angiogenesis [GO:0001525]; apoptotic signaling pathway [GO:0097190]; cellular response to heat [GO:0034605]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of TOR signaling [GO:0032007]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; neural crest cell development [GO:0014032]; neural crest formation [GO:0014029]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of protein monoubiquitination [GO:1902527]; response to calcium ion [GO:0051592]; vascular endothelial growth factor receptor-2 signaling pathway [GO:0036324]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O75340-1; Sequence=Displayed; Name=2; Synonyms=ALG-2(delta)GF122; IsoId=O75340-2; Sequence=VSP_045113; Name=3; IsoId=O75340-3; Sequence=VSP_045542; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16957052, ECO:0000269|PubMed:27813252}; Peripheral membrane protein {ECO:0000269|PubMed:16957052}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:27716508}. Cytoplasm {ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27784779}. Nucleus {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:27784779}. Endosome {ECO:0000269|PubMed:19864416}. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules (PubMed:21122810). In response to calcium increase, relocates from cytoplasm to COPII vesicle coat (PubMed:27716508). Localizes to endoplasmic reticulum exit site (ERES) (PubMed:27813252). {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:27716508, ECO:0000269|PubMed:27813252}.


