# annotation

uniprotID: Q6P5S7
geneSymbol: RNASEK
name: Ribonuclease kappa (RNase K) (RNase kappa) (EC 3.1.-.-)
length: 137
go: ENSG00000219200;
opentargets: integral component of membrane [GO:0016021]; endoribonuclease activity [GO:0004521]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MGWLRPGPRPLCPPARASWAFSHRFPSPLAPRRSPTPFFMASLLCCGPKLAACGIVLSAWGVIMLIMLGIFFNVHSAVLIEDVPFTEKDFENGPQNIYNLYEQVSYNCFIAAGLYLLLGGFSFCQVRLNKRKEYMVR

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P5S7-1; Sequence=Displayed; Name=2; IsoId=Q6P5S7-2; Sequence=VSP_046496; 


uniprotID: P18621
geneSymbol: RPL17
pdb: 4UG0;4V6X;5A8L;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L17 (60S ribosomal protein L23) (Large ribosomal subunit protein uL22) (PD-1)
length: 184
go: ENSG00000265681;
sequence:
MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLQKQCVPFRRYNGGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRRTYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; nucleus [GO:0005634]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P18621-1; Sequence=Displayed; Name=2; IsoId=P18621-2; Sequence=VSP_045445; Name=3; IsoId=P18621-3; Sequence=VSP_046965; 


uniprotID: Q9H5N1
geneSymbol: RABEP2
name: Rab GTPase-binding effector protein 2 (Rabaptin-5beta)
length: 569
go: ENSG00000177548;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; growth factor activity [GO:0008083]; GTPase activator activity [GO:0005096]; endocytosis [GO:0006897]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H5N1-1; Sequence=Displayed; Name=2; IsoId=Q9H5N1-2; Sequence=VSP_010458, VSP_010459; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9524116}. Early endosome {ECO:0000269|PubMed:9524116}.


uniprotID: Q86WH2
geneSymbol: RASSF3
name: Ras association domain-containing protein 3
length: 238
go: ENSG00000153179;
snps: rs74098110
sequence:

opentargets:
cytosol [GO:0005829]; microtubule [GO:0005874]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=A; IsoId=Q86WH2-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q86WH2-2; Sequence=VSP_019353, VSP_019354; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15569673}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15569673}. Note=Localized to microtubules in vascular endothelial cells.


uniprotID: P10276
geneSymbol: RARA
reactome: R-HSA-383280;R-HSA-4090294;R-HSA-5362517;R-HSA-5617472;
pdb: 1DKF;1DSZ;3A9E;3KMR;3KMZ;4DQM;5K13;
name: Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
length: 462
go: ENSG00000131759;
drug: DB00459;DB00210;DB00523;DB00926;DB00982;DB05785;DB04942;DB00799;
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RNA polymerase II transcription factor complex [GO:0090575]; alpha-actinin binding [GO:0051393]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; drug binding [GO:0008144]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; mRNA 5'-UTR binding [GO:0048027]; nuclear receptor transcription coactivator activity [GO:0030374]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein kinase A binding [GO:0051018]; protein kinase B binding [GO:0043422]; retinoic acid binding [GO:0001972]; retinoic acid receptor activity [GO:0003708]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; steroid hormone receptor activity [GO:0003707]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; zinc ion binding [GO:0008270]; apoptotic cell clearance [GO:0043277]; bone morphogenesis [GO:0060349]; cell differentiation [GO:0030154]; cellular response to estrogen stimulus [GO:0071391]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; chondroblast differentiation [GO:0060591]; embryonic camera-type eye development [GO:0031076]; epithelium development [GO:0060429]; face development [GO:0060324]; female pregnancy [GO:0007565]; germ cell development [GO:0007281]; gland development [GO:0048732]; glandular epithelial cell development [GO:0002068]; growth plate cartilage development [GO:0003417]; hippocampus development [GO:0021766]; hormone-mediated signaling pathway [GO:0009755]; limb development [GO:0060173]; liver development [GO:0001889]; multicellular organism development [GO:0007275]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cartilage development [GO:0061037]; negative regulation of cell proliferation [GO:0008285]; negative regulation of granulocyte differentiation [GO:0030853]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of tumor necrosis factor production [GO:0032720]; neural tube closure [GO:0001843]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of binding [GO:0051099]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of interleukin-13 production [GO:0032736]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-5 production [GO:0032754]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of T-helper 2 cell differentiation [GO:0045630]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; prostate gland development [GO:0030850]; protein phosphorylation [GO:0006468]; regulation of myelination [GO:0031641]; regulation of synaptic plasticity [GO:0048167]; response to cytokine [GO:0034097]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to lipid [GO:0033993]; response to retinoic acid [GO:0032526]; response to vitamin A [GO:0033189]; retinoic acid receptor signaling pathway [GO:0048384]; Sertoli cell fate commitment [GO:0060010]; signal transduction [GO:0007165]; spermatogenesis [GO:0007283]; trachea cartilage development [GO:0060534]; transcription initiation from RNA polymerase II promoter [GO:0006367]; ureteric bud development [GO:0001657]; ventricular cardiac muscle cell differentiation [GO:0055012]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Alpha-1; IsoId=P10276-1; Sequence=Displayed; Name=Alpha-2; IsoId=P10276-2; Sequence=VSP_003629; Name=Alpha-1-deltaBC; IsoId=P10276-3; Sequence=VSP_043143; Note=Does not bind nor transactivate RARE on its own but may do so as a heterodimer with Alpha-1.; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation.


uniprotID: Q5JQD4
geneSymbol: PYY3
name: Putative peptide YY-3 (Putative peptide YY3) (PYY-III)
sequence: MVSVCRPWPAVAIALLALLVCLGALVDTCPIKPEAPGEDESLEELSHYYASLCHYLNVVTRQWWEGADMW
length: 70
snps: rs5953365
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
opentargets:
extracellular space [GO:0005615]; G protein-coupled receptor binding [GO:0001664]; neuropeptide hormone activity [GO:0005184]; neuropeptide signaling pathway [GO:0007218]


uniprotID: P14927
geneSymbol: UQCRB
reactome: R-HSA-611105;
pdb: 5XTE;5XTH;5XTI;
length: 111
go: ENSG00000156467;
drug: DB08453;DB07778;DB07401;DB08330;DB08690;
snps: rs35895613
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane.
name:
Cytochrome b-c1 complex subunit 7 (Complex III subunit 7) (Complex III subunit VII) (QP-C) (Ubiquinol-cytochrome c reductase complex 14 kDa protein)

sequence:
MAGKQAVSASGKWLDGIRKWYYNAAGFNKLGLMRDDTIYEDEDVKEAIRRLPENLYNDRMFRIKRALDLNLKHQILPKEQWTKYEEENFYLEPYLKEVIRERKEREEWAKK

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain [GO:0005746]; mitochondrial respiratory chain complex III [GO:0005750]; aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]; oxidation-reduction process [GO:0055114]; oxidative phosphorylation [GO:0006119]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P14927-1; Sequence=Displayed; Name=2; IsoId=P14927-2; Sequence=VSP_045601; Note=No experimental confirmation available.; 


uniprotID: Q5R372
geneSymbol: RABGAP1L
pdb: 3HZJ;
name: Rab GTPase-activating protein 1-like
length: 815
go: ENSG00000152061;
snps: rs7339904
sequence:

opentargets:
early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; regulation of protein localization [GO:0032880]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=10;  Name=1 {ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:16710414}; IsoId=Q5R372-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16710414}; IsoId=Q5R372-2; Sequence=VSP_052916, VSP_052919, VSP_052920; Name=3 {ECO:0000269|PubMed:16710414}; IsoId=Q5R372-3; Sequence=VSP_052917; Name=4 {ECO:0000269|PubMed:16533400}; IsoId=Q5R372-4; Sequence=VSP_052918; Name=5 {ECO:0000269|PubMed:16710414, ECO:0000269|Ref.1}; IsoId=Q5R372-5; Sequence=VSP_052915, VSP_035087, VSP_052924; Name=6 {ECO:0000269|PubMed:16710414, ECO:0000269|Ref.1}; IsoId=Q5R372-6; Sequence=VSP_052915, VSP_052921, VSP_052924; Name=7 {ECO:0000269|PubMed:16710414, ECO:0000269|Ref.1}; IsoId=Q5R372-7; Sequence=VSP_052913, VSP_052924; Name=8 {ECO:0000269|PubMed:16710414, ECO:0000269|PubMed:9455484}; IsoId=Q5R372-8; Sequence=VSP_052914, VSP_052922, VSP_052924; Name=9 {ECO:0000269|PubMed:15489334}; IsoId=Q5R372-9; Sequence=VSP_052912, VSP_052923; Name=10; Synonyms=D; IsoId=B7ZAP0-1; Sequence=External; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:A6H6A9}. Early endosome {ECO:0000269|PubMed:16923123}. Golgi apparatus {ECO:0000269|PubMed:16923123}. Note=Colocalizes on endosomes partially with EEA1 (PubMed:16923123). Colocalizes and cotransports on motile vesicles with ANK2 (By similarity). {ECO:0000250|UniProtKB:A6H6A9, ECO:0000269|PubMed:16923123}.


uniprotID: Q96S59
geneSymbol: RANBP9
reactome: R-HSA-373760;R-HSA-5673001;R-HSA-8851805;
pdb: 5JI7;5JI9;5JIU;
name: Ran-binding protein 9 (RanBP9) (BPM-L) (BPM90) (Ran-binding protein M) (RanBPM) (RanBP7)
length: 729
go: ENSG00000010017;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule associated complex [GO:0005875]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ubiquitin ligase complex [GO:0000151]; enzyme binding [GO:0019899]; Ran GTPase binding [GO:0008536]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; axon guidance [GO:0007411]; MAPK cascade [GO:0000165]; microtubule nucleation [GO:0007020]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; protein-containing complex assembly [GO:0065003]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96S59-1; Sequence=Displayed; Name=2; IsoId=Q96S59-2; Sequence=VSP_013175; Name=3; IsoId=Q96S59-3; Sequence=VSP_056049; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11470507, ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:18222118, ECO:0000269|PubMed:24143168}. Nucleus {ECO:0000269|PubMed:11470507, ECO:0000269|PubMed:14511641, ECO:0000269|PubMed:15381419, ECO:0000269|PubMed:15558019, ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:18222118}. Cell membrane {ECO:0000269|PubMed:14722085}; Peripheral membrane protein {ECO:0000269|PubMed:14722085}. Note=The unphosphorylated form is predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane. {ECO:0000269|PubMed:14722085}.


uniprotID: Q09028
geneSymbol: RBBP4
pdb: 2XU7;3GFC;4PBY;4PBZ;4PC0;4R7A;5FXY;5VTB;5WAI;5WAK;5XWR;5XXQ;5Y1U;6BW3;6BW4;6C23;6C24;6G16;
length: 425
go: ENSG00000162521;
location: SUBCELLULAR LOCATION: Nucleus.
reactome:
R-HSA-1362277;R-HSA-1362300;R-HSA-1538133;R-HSA-156711;R-HSA-212300;R-HSA-2559580;R-HSA-3214815;R-HSA-3214841;R-HSA-427389;R-HSA-539107;R-HSA-5617472;R-HSA-606279;R-HSA-6804758;R-HSA-69202;R-HSA-69656;R-HSA-73762;R-HSA-8943724;R-HSA-8953750;

name:
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)

sequence:

opentargets:
CAF-1 complex [GO:0033186]; cytosol [GO:0005829]; ESC/E(Z) complex [GO:0035098]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; NuRD complex [GO:0016581]; NURF complex [GO:0016589]; protein-containing complex [GO:0032991]; Sin3 complex [GO:0016580]; histone binding [GO:0042393]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; ATP-dependent chromatin remodeling [GO:0043044]; cell cycle [GO:0007049]; CENP-A containing nucleosome assembly [GO:0034080]; chromatin assembly [GO:0031497]; chromatin remodeling [GO:0006338]; DNA replication [GO:0006260]; DNA replication-dependent nucleosome assembly [GO:0006335]; DNA replication-independent nucleosome assembly [GO:0006336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of gene expression, epigenetic [GO:0045814]; regulation of cell cycle [GO:0051726]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q09028-1; Sequence=Displayed; Name=2; IsoId=Q09028-2; Sequence=VSP_040088; Note=No experimental confirmation available.; Name=3; IsoId=Q09028-3; Sequence=VSP_040089; Note=No experimental confirmation available.; Name=4; IsoId=Q09028-4; Sequence=VSP_040087; Note=No experimental confirmation available.; 


uniprotID: Q9H0N0
geneSymbol: RAB6C
name: Ras-related protein Rab-6C (Rab6-like protein WTH3)
length: 254
go: ENSG00000222014;
snps: rs4662674
sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular [GO:0005622]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intra-Golgi vesicle-mediated transport [GO:0006891]; intracellular protein transport [GO:0006886]; mitotic cell cycle [GO:0000278]; Rab protein signal transduction [GO:0032482]; regulation of centrosome duplication [GO:0010824]; response to drug [GO:0042493]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; small GTPase mediated signal transduction [GO:0007264]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16103095}. Cytoplasm {ECO:0000269|PubMed:16103095}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20064528}.


uniprotID: P20337
geneSymbol: RAB3B
reactome: R-HSA-8873719;
pdb: 3DZ8;
name: Ras-related protein Rab-3B
length: 219
go: ENSG00000169213;
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dopaminergic synapse [GO:0098691]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; antigen processing and presentation [GO:0019882]; intracellular protein transport [GO:0006886]; peptidyl-cysteine methylation [GO:0018125]; positive regulation of dopamine uptake involved in synaptic transmission [GO:0051586]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle cycle [GO:0098693]; regulation of vesicle size [GO:0097494]; vesicle docking involved in exocytosis [GO:0006904]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9CZT8}. Note=Colocalizes with GAS8/DRC4 in the Golgi apparatus. {ECO:0000250|UniProtKB:Q9CZT8}.


uniprotID: P26374
geneSymbol: CHML
reactome: R-HSA-8873719;R-HSA-8876198;
length: 656
go: ENSG00000203668;
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12356470}.
name:
Rab proteins geranylgeranyltransferase component A 2 (Choroideremia-like protein) (Rab escort protein 2) (REP-2)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; intracellular protein transport [GO:0006886]; post-translational protein modification [GO:0043687]; protein geranylgeranylation [GO:0018344]; small GTPase mediated signal transduction [GO:0007264]


uniprotID: Q99638
geneSymbol: RAD9A
reactome: R-HSA-176187;R-HSA-5685938;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;
pdb: 3A1J;3G65;3GGR;
length: 391
go: ENSG00000172613;
snps: rs11575913 rs2422490 rs2066492 rs17880039 rs17882466
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12628935}.
name:
Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A)

sequence:

opentargets:
checkpoint clamp complex [GO:0030896]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5' exonuclease activity [GO:0008408]; enzyme binding [GO:0019899]; exodeoxyribonuclease III activity [GO:0008853]; histone deacetylase binding [GO:0042826]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to ionizing radiation [GO:0071479]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]


uniprotID: Q99969
geneSymbol: RARRES2
reactome: R-HSA-114608;
length: 163
go: ENSG00000106538;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein)

sequence:
MRRLLIPLALWLGAVGVGVAELTEAQRRGLQVALEEFHKHPPVQWAFQETSVESAVDTPFPAGIFVRLEFKLQQTSCRKRDWKKPECKVRPNGRKRKCLACIKLGSEDKVLGRLVHCPIETQVLREAEEHQETQCLRVQRAGEDPHSFYFPGQFAFSKALPRS

opentargets:
extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet dense granule lumen [GO:0031089]; signaling receptor binding [GO:0005102]; antifungal humoral response [GO:0019732]; antifungal innate immune response [GO:0061760]; cell differentiation [GO:0030154]; chemotaxis [GO:0006935]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; embryonic digestive tract development [GO:0048566]; in utero embryonic development [GO:0001701]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insulin receptor signaling pathway [GO:0008286]; platelet degranulation [GO:0002576]; positive regulation of chemotaxis [GO:0050921]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; positive regulation of macrophage chemotaxis [GO:0010759]; positive regulation of protein phosphorylation [GO:0001934]; regulation of lipid catabolic process [GO:0050994]; retinoid metabolic process [GO:0001523]


uniprotID: Q9NP90
geneSymbol: RAB9B
reactome: R-HSA-6798695;R-HSA-6811440;R-HSA-8873719;R-HSA-8876198;
pdb: 2OCB;
name: Ras-related protein Rab-9B (Rab-9-like protein) (Rab-9L)
length: 201
go: ENSG00000123570;
sequence:

opentargets:
cytosol [GO:0005829]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; Rab protein signal transduction [GO:0032482]; retrograde transport, endosome to Golgi [GO:0042147]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.


uniprotID: Q9Y272
geneSymbol: RASD1
name: Dexamethasone-induced Ras-related protein 1 (Activator of G-protein signaling 1)
length: 281
go: ENSG00000108551;
sequence:

opentargets:
nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcoplasmic reticulum [GO:0016529]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of transcription, DNA-templated [GO:0045892]; nitric oxide mediated signal transduction [GO:0007263]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y272-1; Sequence=Displayed; Name=2; IsoId=Q9Y272-2; Sequence=VSP_046431, VSP_046432; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.


uniprotID: A4D1S5
geneSymbol: RAB19
reactome: R-HSA-8873719;
name: Ras-related protein Rab-19
length: 217
go: ENSG00000146955;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A4D1S5-1; Sequence=Displayed; Name=2; IsoId=A4D1S5-2; Sequence=VSP_036588; Note=No experimental confirmation available.; 


uniprotID: O14807
geneSymbol: MRAS
name: Ras-related protein M-Ras (Ras-related protein R-Ras3)
length: 208
go: ENSG00000158186;
sequence:

opentargets:
intracellular [GO:0005622]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; actin cytoskeleton organization [GO:0030036]; cellular response to leukemia inhibitory factor [GO:1990830]; multicellular organism development [GO:0007275]; muscle organ development [GO:0007517]; Ras protein signal transduction [GO:0007265]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14807-1; Sequence=Displayed; Name=2; IsoId=O14807-2; Sequence=VSP_044792; 


uniprotID: P60763
geneSymbol: RAC3
reactome: R-HSA-194840;R-HSA-4086400;
pdb: 2C2H;2G0N;2IC5;2OV2;2QME;
name: Ras-related C3 botulinum toxin substrate 3 (p21-Rac3)
length: 192
go: ENSG00000169750;
sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF

opentargets:
cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filamentous actin [GO:0031941]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin cytoskeleton reorganization [GO:0031532]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; cell morphogenesis [GO:0000902]; cell projection assembly [GO:0030031]; cerebral cortex GABAergic interneuron development [GO:0021894]; engulfment of apoptotic cell [GO:0043652]; homeostasis of number of cells within a tissue [GO:0048873]; intracellular signal transduction [GO:0035556]; neuromuscular process controlling balance [GO:0050885]; neuron projection development [GO:0031175]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of cell adhesion mediated by integrin [GO:0033630]; positive regulation of substrate adhesion-dependent cell spreading [GO:1900026]; regulation of neuron maturation [GO:0014041]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]; synaptic transmission, GABAergic [GO:0051932]

location:
SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery.


uniprotID: Q6WBX8
geneSymbol: RAD9B
reactome: R-HSA-176187;R-HSA-5685938;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;
name: Cell cycle checkpoint control protein RAD9B (DNA repair exonuclease rad9 homolog B) (hRAD9B)
length: 426
go: ENSG00000151164;
sequence:

opentargets:
checkpoint clamp complex [GO:0030896]; nucleoplasm [GO:0005654]; 3'-5' exonuclease activity [GO:0008408]; cellular response to ionizing radiation [GO:0071479]; DNA repair [GO:0006281]; intra-S DNA damage checkpoint [GO:0031573]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=5; IsoId=Q6WBX8-5; Sequence=Displayed; Note=No experimental confirmation available.; Name=1; IsoId=Q6WBX8-1; Sequence=VSP_017446; Name=2; IsoId=Q6WBX8-2; Sequence=VSP_017445, VSP_017446; Note=No experimental confirmation available.; Name=3; IsoId=Q6WBX8-3; Sequence=VSP_017444, VSP_017446; Name=4; IsoId=Q6WBX8-4; Sequence=VSP_017444; Note=No experimental confirmation available.; 


uniprotID: P78332
geneSymbol: RBM6
length: 1123
go: ENSG00000004534;
snps: rs61731329 rs34707170
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
RNA-binding protein 6 (Lung cancer antigen NY-LU-12) (Protein G16) (RNA-binding motif protein 6) (RNA-binding protein DEF-3)

sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; RNA processing [GO:0006396]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P78332-1; Sequence=Displayed; Name=2; IsoId=P78332-2; Sequence=VSP_045202; Note=No experimental confirmation available.; Name=3; IsoId=P78332-3; Sequence=VSP_057401, VSP_057402; Note=No experimental confirmation available.; 


uniprotID: Q15042
geneSymbol: RAB3GAP1
reactome: R-HSA-6811436;R-HSA-8876198;
length: 981
go: ENSG00000115839;
snps: rs10445686
name:
Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; lipid droplet [GO:0005811]; postsynapse [GO:0098794]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; Rab GTPase binding [GO:0017137]; brain development [GO:0007420]; camera-type eye development [GO:0043010]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; excitatory postsynaptic potential [GO:0060079]; face morphogenesis [GO:0060325]; hypothalamus development [GO:0021854]; lipid droplet organization [GO:0034389]; positive regulation of autophagosome assembly [GO:2000786]; positive regulation of endoplasmic reticulum tubular network organization [GO:1903373]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [GO:0061646]; positive regulation of GTPase activity [GO:0043547]; positive regulation of protein lipidation [GO:1903061]; regulation of calcium ion-dependent exocytosis of neurotransmitter [GO:1903233]; regulation of GTPase activity [GO:0043087]; regulation of short-term neuronal synaptic plasticity [GO:0048172]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q15042-1; Sequence=Displayed; Name=2; IsoId=Q15042-3; Sequence=VSP_054068; Note=No experimental confirmation available.; Name=3; IsoId=Q15042-4; Sequence=VSP_054475, VSP_054476; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9852129}. Note=In neurons, it is enriched in the synaptic soluble fraction.


uniprotID: Q9P258
geneSymbol: RCC2
reactome: R-HSA-141444;R-HSA-2467813;R-HSA-2500257;R-HSA-5663220;R-HSA-68877;
pdb: 5GWN;
name: Protein RCC2 (RCC1-like protein TD-60) (Telophase disk protein of 60 kDa)
length: 522
go: ENSG00000179051;
sequence:

opentargets:
chromosome, centromeric core domain [GO:0034506]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; microtubule [GO:0005874]; midbody [GO:0030496]; mitotic spindle midzone [GO:1990023]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; guanyl-nucleotide exchange factor activity [GO:0005085]; microtubule binding [GO:0008017]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; Rac GTPase binding [GO:0048365]; RNA binding [GO:0003723]; small GTPase binding [GO:0031267]; activation of GTPase activity [GO:0090630]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to kinetochore [GO:0072356]; establishment of protein localization [GO:0045184]; focal adhesion assembly [GO:0048041]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of GTPase activity [GO:0034260]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; positive regulation of attachment of spindle microtubules to kinetochore [GO:0051987]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; regulation of cell migration [GO:0030334]; regulation of fibroblast migration [GO:0010762]; regulation of ruffle assembly [GO:1900027]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305|PubMed:12429849}. Nucleus {ECO:0000269|PubMed:23388455}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23388455}. Chromosome, centromere {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Chromosome {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Midbody {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:9914378}. Cell membrane {ECO:0000269|PubMed:25074804}; Peripheral membrane protein {ECO:0000305|PubMed:25074804}; Cytoplasmic side {ECO:0000305|PubMed:25074804}. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex (PubMed:12919680, PubMed:1939370, PubMed:7559776, PubMed:9914378). Colocalizes with cytoplasmic microtubules in interphase cells (PubMed:23388455). Colocalizes with RAC1 at the cell membrane (PubMed:25074804). {ECO:0000269|PubMed:12919680, ECO:0000269|PubMed:1939370, ECO:0000269|PubMed:23388455, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:7559776, ECO:0000269|PubMed:9914378}.


uniprotID: Q9Y4C8
geneSymbol: RBM19
pdb: 2DGW;
name: Probable RNA-binding protein 19 (RNA-binding motif protein 19)
length: 960
go: ENSG00000122965;
snps: rs7299217 rs2290789 rs2290788 rs2290787 rs16943379 rs2075387
sequence:

opentargets:
chromosome [GO:0005694]; cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; mRNA cis splicing, via spliceosome [GO:0045292]; multicellular organism development [GO:0007275]; positive regulation of embryonic development [GO:0040019]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16027046}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In discrete foci distributed throughout the cytoplasm and nucleoplasm during the 4 to 8 cell stages and the morula stage, but not in the periphery of the nucleolar precursor body (NPB). During blastocyst development, becomes increasingly localized to the nucleolus and less to the cytoplasm. At the late blastocyst stage, localized predominantly in the nucleolus. Localized in the nucleolus during interphase and to the perichromosomal sheath during mitosis. Does not colocalize in the cytoplasm with GW182 in P-bodies. May translocate to the nucleolus upon early embryonic development (By similarity). Colocalizes with NPM1 during interphase. By late prophase, metaphase, anaphase and telophase, associates with the chromosome periphery. By telophase localizes to NPB. {ECO:0000250}.


uniprotID: O60894
geneSymbol: RAMP1
reactome: R-HSA-418555;R-HSA-419812;
pdb: 2YX8;3N7P;3N7R;3N7S;4RWG;5V6Y;6D1U;6E3Y;
length: 148
go: ENSG00000132329;
drug: DB01278;
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1)

sequence:
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV

opentargets:
amylin receptor complex 1 [GO:0150056]; cell surface [GO:0009986]; CGRP receptor complex [GO:1990406]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; amylin receptor activity [GO:0097643]; calcitonin gene-related peptide binding [GO:1990407]; calcitonin gene-related peptide receptor activity [GO:0001635]; coreceptor activity [GO:0015026]; protein transporter activity [GO:0008565]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; calcitonin gene-related peptide receptor signaling pathway [GO:1990408]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular protein transport [GO:0006886]; positive regulation of protein glycosylation [GO:0060050]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]


uniprotID: Q9Y3L5
geneSymbol: RAP2C
reactome: R-HSA-6798695;
name: Ras-related protein Rap-2c
length: 183
go: ENSG00000123728;
sequence:
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

opentargets:
bicellular tight junction [GO:0005923]; cell-cell contact zone [GO:0044291]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; tertiary granule membrane [GO:0070821]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; transcription coactivator activity [GO:0003713]; establishment of endothelial intestinal barrier [GO:0090557]; negative regulation of cell migration [GO:0030336]; neutrophil degranulation [GO:0043312]; positive regulation of protein autophosphorylation [GO:0031954]; Rap protein signal transduction [GO:0032486]; regulation of protein tyrosine kinase activity [GO:0061097]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17447155}. Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q14498
geneSymbol: RBM39
pdb: 2JRS;2MHN;4OO6;4OZ0;4OZ1;4YUD;
length: 530
go: ENSG00000131051;
snps: rs1803701
name:
RNA-binding protein 39 (CAPER alpha) (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)

sequence:

opentargets:
microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; RNA processing [GO:0006396]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=HCC1.4; IsoId=Q14498-1; Sequence=Displayed; Name=2; Synonyms=HCC1.3; IsoId=Q14498-2; Sequence=VSP_005820; Name=3; IsoId=Q14498-3; Sequence=VSP_043375; 

location:
SUBCELLULAR LOCATION: Nucleus speckle. Note=Concentrated in nuclear speckles. Colocalizes with the core spliceosomal snRNP proteins.


uniprotID: P61026
geneSymbol: RAB10
reactome: R-HSA-1445148;R-HSA-6798695;R-HSA-8873719;R-HSA-8876198;
pdb: 5LPN;5SZJ;
name: Ras-related protein Rab-10
length: 200
go: ENSG00000084733;
sequence:

opentargets:
cell-cell adherens junction [GO:0005913]; cilium [GO:0005929]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; exocytic vesicle [GO:0070382]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule membrane [GO:0030667]; synaptic vesicle [GO:0008021]; trans-Golgi network [GO:0005802]; cadherin binding involved in cell-cell adhesion [GO:0098641]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; antigen processing and presentation [GO:0019882]; axonogenesis [GO:0007409]; cellular response to insulin stimulus [GO:0032869]; endoplasmic reticulum tubular network organization [GO:0071786]; endosomal transport [GO:0016197]; establishment of neuroblast polarity [GO:0045200]; establishment of protein localization to endoplasmic reticulum membrane [GO:0097051]; establishment of protein localization to membrane [GO:0090150]; Golgi to plasma membrane protein transport [GO:0043001]; Golgi to plasma membrane transport [GO:0006893]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; polarized epithelial cell differentiation [GO:0030859]; protein localization to basolateral plasma membrane [GO:1903361]; protein localization to plasma membrane [GO:0072659]; protein secretion [GO:0009306]; Rab protein signal transduction [GO:0032482]; regulation of exocytosis [GO:0017157]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:23263280}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P24409}. Endosome membrane {ECO:0000269|PubMed:16641372}. Recycling endosome membrane {ECO:0000250|UniProtKB:P24409}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P24409}. Cell projection, cilium {ECO:0000269|PubMed:20576682}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23263280}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P61027}. Note=Associates with SLC2A4/GLUT4 storage vesicles (PubMed:22908308). Localizes to the base of the cilium (PubMed:20576682). Transiently associates with phagosomes (By similarity). Localizes to the endoplasmic reticulum at domains of new tubule growth (PubMed:23263280). {ECO:0000250|UniProtKB:P24409, ECO:0000269|PubMed:20576682, ECO:0000269|PubMed:22908308, ECO:0000269|PubMed:23263280}.


uniprotID: Q6IQ22
geneSymbol: RAB12
reactome: R-HSA-8873719;R-HSA-8876198;
pdb: 2IL1;
name: Ras-related protein Rab-12
length: 244
go: ENSG00000206418;
sequence:

opentargets:
autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; phagocytic vesicle [GO:0045335]; recycling endosome membrane [GO:0055038]; trans-Golgi network [GO:0005802]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagy [GO:0006914]; cellular protein catabolic process [GO:0044257]; cellular response to interferon-gamma [GO:0071346]; endosome to lysosome transport [GO:0008333]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; positive regulation of macroautophagy [GO:0016239]; Rab protein signal transduction [GO:0032482]

location:
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51152}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P35283}.


uniprotID: Q8NHQ8
geneSymbol: RASSF8
pdb: 2CS4;
name: Ras association domain-containing protein 8 (Carcinoma-associated protein HOJ-1)
length: 419
go: ENSG00000123094;
opentargets: adherens junction maintenance [GO:0034334]; signal transduction [GO:0007165]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NHQ8-1; Sequence=Displayed; Name=2; IsoId=Q8NHQ8-2; Sequence=VSP_014248; 


uniprotID: Q8IZP6
geneSymbol: RNF113B
pdb: 2CSY;
name: RING finger protein 113B (Zinc finger protein 183-like 1)
length: 322
go: ENSG00000139797;
snps: rs16955011
sequence:

opentargets:
U2-type spliceosomal complex [GO:0005684]; metal ion binding [GO:0046872]; snoRNA splicing [GO:0034247]


uniprotID: P38159
geneSymbol: RBMX
reactome: R-HSA-72163;R-HSA-72203;
pdb: 2MB0;2MKS;
length: 391
go: ENSG00000147274;
name:
RNA-binding motif protein, X chromosome (Glycoprotein p43) (Heterogeneous nuclear ribonucleoprotein G) (hnRNP G) [Cleaved into: RNA-binding motif protein, X chromosome, N-terminally processed]

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; membrane [GO:0016020]; nuclear euchromatin [GO:0005719]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; supraspliceosomal complex [GO:0044530]; chromatin binding [GO:0003682]; identical protein binding [GO:0042802]; mRNA binding [GO:0003729]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; single-stranded RNA binding [GO:0003727]; cellular response to interleukin-1 [GO:0071347]; membrane protein ectodomain proteolysis [GO:0006509]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; osteoblast differentiation [GO:0001649]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA metabolic process [GO:0016070]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P38159-1; Sequence=Displayed; Name=2; IsoId=P38159-2; Sequence=VSP_042203; Name=3; IsoId=P38159-3; Sequence=VSP_043650, VSP_043651; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19282290, ECO:0000269|PubMed:21327109}. Note=Component of ribonucleosomes. Localizes in numerous small granules in the nucleus.


uniprotID: P49756
geneSymbol: RBM25
pdb: 3V53;
length: 843
go: ENSG00000119707;
name:
RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of apoptotic process [GO:0042981]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P49756-1; Sequence=Displayed; Name=2; IsoId=P49756-2; Sequence=VSP_036792, VSP_036793; Note=No experimental confirmation available.; Name=3; IsoId=P49756-3; Sequence=VSP_036791, VSP_036794; Name=4; IsoId=P49756-4; Sequence=VSP_039881, VSP_039882; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.


uniprotID: P0C881
geneSymbol: RSPH10B
name: Radial spoke head 10 homolog B
length: 870
go: ENSG00000155026;
sequence:


uniprotID: Q96DA2
geneSymbol: RAB39B
reactome: R-HSA-8873719;R-HSA-8876198;
name: Ras-related protein Rab-39B
length: 213
go: ENSG00000155961;
snps: rs587777874 rs864309527
sequence:

opentargets:
cytoplasmic vesicle membrane [GO:0030659]; Golgi apparatus [GO:0005794]; intracellular [GO:0005622]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; autophagy [GO:0006914]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]; regulation of autophagy [GO:0010506]; synapse organization [GO:0050808]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:26399558}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:20159109, ECO:0000269|PubMed:24349490}. Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network. {ECO:0000250|UniProtKB:Q8BHC1}.


uniprotID: Q6VN20
geneSymbol: RANBP10
reactome: R-HSA-8851805;
name: Ran-binding protein 10 (RanBP10)
length: 620
go: ENSG00000141084;
opentargets: cytosol [GO:0005829]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6VN20-1; Sequence=Displayed; Name=2; IsoId=Q6VN20-2; Sequence=VSP_055839, VSP_055841; Note=No experimental confirmation available.; Name=3; IsoId=Q6VN20-3; Sequence=VSP_055840, VSP_055841; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18222118}. Nucleus {ECO:0000269|PubMed:18222118}. Note=Predominantly cytoplasmic.


uniprotID: Q9HBH5
geneSymbol: RDH14
reactome: R-HSA-5365859;
length: 336
go: ENSG00000240857;
drug: DB00162;
name:
Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2) (Short chain dehydrogenase/reductase family 7C member 4)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleus [GO:0005634]; NADP-retinol dehydrogenase activity [GO:0052650]; osteoblast differentiation [GO:0001649]


uniprotID: P35241
geneSymbol: RDX
reactome: R-HSA-437239;
name: Radixin
length: 583
go: ENSG00000137710;
snps: rs17854427 rs34471100 rs121918379
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cell tip [GO:0051286]; cell-cell adherens junction [GO:0005913]; cleavage furrow [GO:0032154]; cortical actin cytoskeleton [GO:0030864]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; midbody [GO:0030496]; myelin sheath [GO:0043209]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; stereocilium [GO:0032420]; T-tubule [GO:0030315]; actin binding [GO:0003779]; ATPase binding [GO:0051117]; cadherin binding [GO:0045296]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; protein kinase A binding [GO:0051018]; RNA binding [GO:0003723]; apical protein localization [GO:0045176]; barbed-end actin filament capping [GO:0051016]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to thyroid hormone stimulus [GO:0097067]; establishment of endothelial barrier [GO:0061028]; establishment of protein localization [GO:0045184]; microvillus assembly [GO:0030033]; negative regulation of adherens junction organization [GO:1903392]; negative regulation of cell size [GO:0045792]; negative regulation of GTPase activity [GO:0034260]; negative regulation of homotypic cell-cell adhesion [GO:0034111]; positive regulation of cell migration [GO:0030335]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of gene expression [GO:0010628]; positive regulation of protein localization to early endosome [GO:1902966]; protein kinase A signaling [GO:0010737]; protein localization to plasma membrane [GO:0072659]; regulation of actin filament bundle assembly [GO:0032231]; regulation of cell shape [GO:0008360]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of organelle assembly [GO:1902115]; regulation of Rap protein signal transduction [GO:0032487]; regulation of ruffle assembly [GO:1900027]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P35241-1; Sequence=Displayed; Name=2; IsoId=P35241-2; Sequence=VSP_045315, VSP_045318; Name=3; IsoId=P35241-3; Sequence=VSP_045316, VSP_045317, VSP_045318; Name=4; IsoId=P35241-4; Sequence=VSP_047276; Name=5; IsoId=P35241-5; Sequence=VSP_045318; 

location:
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus {ECO:0000250|UniProtKB:P26043}. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.


uniprotID: Q15291
geneSymbol: RBBP5
reactome: R-HSA-201722;R-HSA-3214841;R-HSA-3769402;R-HSA-5617472;R-HSA-8936459;R-HSA-8951664;
pdb: 3P4F;4X8N;4X8P;5F6K;5F6L;
name: Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
length: 538
go: ENSG00000117222;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17355966}.
sequence:

opentargets:
histone methyltransferase complex [GO:0035097]; MLL1 complex [GO:0071339]; MLL3/4 complex [GO:0044666]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; histone-lysine N-methyltransferase activity [GO:0018024]; methylated histone binding [GO:0035064]; transcription regulatory region DNA binding [GO:0044212]; beta-catenin-TCF complex assembly [GO:1904837]; cellular response to DNA damage stimulus [GO:0006974]; histone H3-K4 methylation [GO:0051568]; post-translational protein modification [GO:0043687]; regulation of megakaryocyte differentiation [GO:0045652]; response to estrogen [GO:0043627]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15291-1; Sequence=Displayed; Name=2; IsoId=Q15291-2; Sequence=VSP_035583; 


uniprotID: Q15311
geneSymbol: RALBP1
reactome: R-HSA-194840;
pdb: 2KWH;2KWI;2MBG;
length: 655
go: ENSG00000017797;
drug: DB00564;DB00997;DB00398;DB00541;
snps: rs35867116
name:
RalA-binding protein 1 (RalBP1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase) (Ral-interacting protein 1)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; ATPase activity, coupled to transmembrane movement of substances [GO:0042626]; drug transmembrane transporter activity [GO:0015238]; GTPase activator activity [GO:0005096]; Rac GTPase binding [GO:0048365]; Ral GTPase binding [GO:0017160]; transmembrane transporter activity [GO:0022857]; chemotaxis [GO:0006935]; doxorubicin transport [GO:1900753]; drug transmembrane transport [GO:0006855]; endocytosis [GO:0006897]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; transmembrane transport [GO:0055085]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11437348}; Peripheral membrane protein {ECO:0000269|PubMed:11437348}.


uniprotID: A6NED2
geneSymbol: RCCD1
pdb: 6F4R;6F4S;6F4T;
name: RCC1 domain-containing protein 1
length: 376
go: ENSG00000166965;
snps: rs4932380
sequence:

opentargets:
chromosome [GO:0005694]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; chromatin organization [GO:0006325]

location:
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24981860}. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269|PubMed:24981860}.


uniprotID: Q8WWW0
geneSymbol: RASSF5
pdb: 4LGD;4OH8;
length: 418
go: ENSG00000266094;
name:
Ras association domain-containing protein 5 (New ras effector 1) (Regulator for cell adhesion and polarization enriched in lymphoid tissues) (RAPL)

sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; Ras GTPase binding [GO:0017016]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; negative regulation of cell proliferation [GO:0008285]; positive regulation of protein ubiquitination [GO:0031398]; regulation of apoptotic process [GO:0042981]; regulation of protein localization to nucleus [GO:1900180]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=A, NORE1A; IsoId=Q8WWW0-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WWW0-2; Sequence=VSP_019363, VSP_019364; Name=3; Synonyms=C, NORE1B; IsoId=Q8WWW0-3; Sequence=VSP_019365, VSP_019366; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.


uniprotID: P62491
geneSymbol: RAB11A
reactome: R-HSA-1445148;R-HSA-432040;R-HSA-5620912;R-HSA-5620916;R-HSA-8854214;R-HSA-8873719;
name: Ras-related protein Rab-11A (Rab-11) (YL8)
length: 216
go: ENSG00000103769;
drug: DB01864;DB04315;
pdb:
1OIV;1OIW;1OIX;1YZK;2D7C;2GZD;2GZH;2HV8;4C4P;4D0L;4D0M;4LWZ;4LX0;4UJ3;4UJ4;4UJ5;5C46;5C4G;5EUQ;5EZ5;5FBL;5FBQ;5FBR;5FBV;5FBW;5JCZ;6DJL;

sequence:

opentargets:
axon [GO:0030424]; cleavage furrow [GO:0032154]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; multivesicular body [GO:0005771]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; postsynaptic recycling endosome [GO:0098837]; protein-containing complex [GO:0032991]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; Schaffer collateral - CA1 synapse [GO:0098685]; spindle pole [GO:0000922]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; microtubule binding [GO:0008017]; myosin V binding [GO:0031489]; syntaxin binding [GO:0019905]; astral microtubule organization [GO:0030953]; ciliary basal body-plasma membrane docking [GO:0097711]; establishment of protein localization to membrane [GO:0090150]; establishment of protein localization to organelle [GO:0072594]; establishment of vesicle localization [GO:0051650]; exocytosis [GO:0006887]; exosomal secretion [GO:1990182]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; multivesicular body assembly [GO:0036258]; neuron projection development [GO:0031175]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; plasma membrane to endosome transport [GO:0048227]; positive regulation of axon extension [GO:0045773]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of protein localization to plasma membrane [GO:1903078]; post-translational protein modification [GO:0043687]; protein localization to plasma membrane [GO:0072659]; Rab protein signal transduction [GO:0032482]; regulation of cytokinesis [GO:0032465]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of multivesicular body size [GO:0010796]; regulation of protein transport [GO:0051223]; regulation of vesicle-mediated transport [GO:0060627]; renal water homeostasis [GO:0003091]; vesicle-mediated transport [GO:0016192]; vesicle-mediated transport in synapse [GO:0099003]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P62491-1; Sequence=Displayed; Name=2; IsoId=P62491-2; Sequence=VSP_046755; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15304524}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Recycling endosome membrane {ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:15181150, ECO:0000269|PubMed:29514919}; Lipid-anchor {ECO:0000305|PubMed:24023390}. Cleavage furrow {ECO:0000269|PubMed:15601896}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Note=Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (PubMed:11994279). Localizes to the cleavage furrow (PubMed:15601896). Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis (PubMed:20890297). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:11994279, ECO:0000269|PubMed:15601896, ECO:0000269|PubMed:20890297, ECO:0000269|PubMed:21255211}.


uniprotID: Q92804
geneSymbol: TAF15
pdb: 2MMY;
length: 592
go: ENSG00000270647;
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-674695;R-HSA-6804756;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
TATA-binding protein-associated factor 2N (68 kDa TATA-binding protein-associated factor) (TAF(II)68) (TAFII68) (RNA-binding protein 56)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=Q92804-1; Sequence=Displayed; Name=Short; IsoId=Q92804-2; Sequence=VSP_005806; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19124016}. Cytoplasm {ECO:0000269|PubMed:19124016}. Note=Shuttles from the nucleus to the cytoplasm.


uniprotID: Q6XE24
geneSymbol: RBMS3
name: RNA-binding motif, single-stranded-interacting protein 3
length: 437
go: ENSG00000144642;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10675610}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; poly(A) binding [GO:0008143]; poly(U) RNA binding [GO:0008266]; RNA binding [GO:0003723]; defense response to tumor cell [GO:0002357]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of translation [GO:0045727]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=DD23-L; IsoId=Q6XE24-1; Sequence=Displayed; Name=2; IsoId=Q6XE24-2; Sequence=VSP_022928, VSP_022930, VSP_022931; Name=3; Synonyms=DD23-S; IsoId=Q6XE24-3; Sequence=VSP_022927, VSP_022929; Name=4; IsoId=Q6XE24-4; Sequence=VSP_022930, VSP_022931; Name=5; IsoId=Q6XE24-5; Sequence=VSP_022930; Note=No experimental confirmation available.; 


uniprotID: Q9UBG7
geneSymbol: RBPJL
name: Recombining binding protein suppressor of hairless-like protein (Transcription factor RBP-L)
length: 517
go: ENSG00000124232;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UBG7-1; Sequence=Displayed; Name=2; IsoId=Q9UBG7-2; Sequence=VSP_039150; 


uniprotID: Q8WXH6
geneSymbol: RAB40A
reactome: R-HSA-8873719;
name: Ras-related protein Rab-40A (SOCS box-containing protein RAR2A) (Protein Rar-2)
length: 277
go: ENSG00000172476;
snps: rs1180895
sequence:

opentargets:
Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; protein ubiquitination [GO:0016567]; Rab protein signal transduction [GO:0032482]


uniprotID: Q9UKA8
geneSymbol: RCAN3
length: 241
go: ENSG00000117602;
snps: rs16829813
name:
Calcipressin-3 (Down syndrome candidate region 1-like protein 2) (Myocyte-enriched calcineurin-interacting protein 3) (MCIP3) (Regulator of calcineurin 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; calcium-dependent protein serine/threonine phosphatase regulator activity [GO:0008597]; phosphatase binding [GO:0019902]; RNA binding [GO:0003723]; troponin I binding [GO:0031013]; anatomical structure morphogenesis [GO:0009653]; calcium-mediated signaling [GO:0019722]; regulation of calcineurin-NFAT signaling cascade [GO:0070884]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=RCAN3-1a,2,3,4,5; IsoId=Q9UKA8-1; Sequence=Displayed; Name=2; IsoId=Q9UKA8-2; Sequence=VSP_001319; Name=3; IsoId=Q9UKA8-3; Sequence=VSP_045970, VSP_045971; Name=4; IsoId=Q9UKA8-4; Sequence=VSP_045968, VSP_045969; Name=5; Synonyms=RCAN3-2,4,5, RCAN3-1c,2,4,5; IsoId=Q9UKA8-5; Sequence=VSP_047510; Name=6; Synonyms=RCAN3-1,3,4,5, RCAN3-1a,3,4,5, RCAN3-1c,3,4,5; IsoId=Q9UKA8-6; Sequence=VSP_054855; 


uniprotID: Q32P51
geneSymbol: HNRNPA1L2
name: Heterogeneous nuclear ribonucleoprotein A1-like 2 (hnRNP A1-like 2) (hnRNP core protein A1-like 2)
length: 320
snps: rs9536212
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; mRNA transport [GO:0051028]; RNA splicing [GO:0008380]


uniprotID: P57052
geneSymbol: RBM11
pdb: 2YWK;
name: Splicing regulator RBM11 (RNA-binding motif protein 11)
length: 281
go: ENSG00000185272;
snps: rs409782
sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; poly(U) RNA binding [GO:0008266]; protein homodimerization activity [GO:0042803]; single-stranded RNA binding [GO:0003727]; cell differentiation [GO:0030154]; cellular response to oxidative stress [GO:0034599]; mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P57052-1; Sequence=Displayed; Name=2; IsoId=P57052-2; Sequence=VSP_027371; Note=Incomplete sequence.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:21984414}. Nucleus speckle {ECO:0000269|PubMed:21984414}. Note=Enriched in SRSF2-containing splicing speckles; shuttles between nucleoplasm and speckles.


uniprotID: P46060
geneSymbol: RANGAP1
reactome: R-HSA-141444;R-HSA-165054;R-HSA-2467813;R-HSA-2500257;R-HSA-4615885;R-HSA-5663220;R-HSA-68877;
pdb: 1Z5S;2GRN;2GRO;2GRP;2GRQ;2GRR;2IO2;2IO3;2IY0;3UIN;3UIO;3UIP;5D2M;
name: Ran GTPase-activating protein 1 (RanGAP1)
length: 587
go: ENSG00000100401;
snps: rs2229752
sequence:

opentargets:
aggresome [GO:0016235]; axon cytoplasm [GO:1904115]; condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; cytoplasmic periphery of the nuclear pore complex [GO:1990723]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular membrane-bounded organelle [GO:0043231]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nuclear pore cytoplasmic filaments [GO:0044614]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; cadherin binding [GO:0045296]; GTPase activator activity [GO:0005096]; Ran GTPase binding [GO:0008536]; RNA binding [GO:0003723]; ubiquitin protein ligase binding [GO:0031625]; activation of GTPase activity [GO:0090630]; cellular response to vasopressin [GO:1904117]; negative regulation of protein export from nucleus [GO:0046826]; response to axon injury [GO:0048678]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15037602, ECO:0000305|PubMed:8146159}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8146159}. Nucleus envelope {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11854305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}.


uniprotID: Q9Y388
geneSymbol: RBMX2
pdb: 5Z56;5Z57;5Z58;6FF4;
name: RNA-binding motif protein, X-linked 2
length: 322
go: ENSG00000134597;
snps: rs5977266
sequence:

opentargets:
RES complex [GO:0070274]; U2 snRNP [GO:0005686]; RNA binding [GO:0003723]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]


uniprotID: Q7Z6M1
geneSymbol: RABEPK
reactome: R-HSA-6811440;
name: Rab9 effector protein with kelch motifs (40 kDa Rab9 effector protein) (p40)
length: 372
go: ENSG00000136933;
snps: rs13302059 rs17855990 rs13302050 rs1128362 rs34991596 rs17849326 rs15233
sequence:

opentargets:
cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; receptor-mediated endocytosis [GO:0006898]; vesicle docking involved in exocytosis [GO:0006904]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z6M1-1; Sequence=Displayed; Name=2; IsoId=Q7Z6M1-2; Sequence=VSP_023828; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane. Note=Interaction with PIP5K3 and subsequent phosphorylation recruits it to the endosomal membrane.


uniprotID: Q9H2T7
geneSymbol: RANBP17
name: Ran-binding protein 17
length: 1088
go: ENSG00000204764;
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; GTP binding [GO:0005525]; nuclear export signal receptor activity [GO:0005049]; Ran GTPase binding [GO:0008536]; mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H2T7-1; Sequence=Displayed; Name=2; IsoId=Q9H2T7-2; Sequence=VSP_056669, VSP_056670; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}.


uniprotID: P85298
geneSymbol: ARHGAP8
reactome: R-HSA-194840;
name: Rho GTPase-activating protein 8 (Rho-type GTPase-activating protein 8)
length: 464
go: ENSG00000241484;
snps: rs16992915 rs6007344 rs2071762 rs9614957
sequence:

opentargets:
cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P85298-1, Q9NSG0-6; Sequence=Displayed; Name=2; IsoId=P85298-2, Q9NSG0-7; Sequence=VSP_001652, VSP_001656, VSP_001657; Name=3; IsoId=P85298-3; Sequence=VSP_028883; Name=4; IsoId=P85298-4; Sequence=VSP_001652; Note=No experimental confirmation available.; Name=5; IsoId=P85298-5; Sequence=VSP_001652, VSP_054100, VSP_054101; 


uniprotID: Q9BRR9
geneSymbol: ARHGAP9
reactome: R-HSA-194840;R-HSA-6798695;
pdb: 2P0D;2P0F;2P0H;
name: Rho GTPase-activating protein 9 (Rho-type GTPase-activating protein 9)
length: 750
go: ENSG00000123329;
snps: rs33927108 rs3802989 rs11544238
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; secretory granule lumen [GO:0034774]; GTPase activator activity [GO:0005096]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; neutrophil degranulation [GO:0043312]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9BRR9-1; Sequence=Displayed; Name=2; IsoId=Q9BRR9-2; Sequence=VSP_010325; Name=3; IsoId=Q9BRR9-3; Sequence=VSP_010340; Name=4; IsoId=Q9BRR9-4; Sequence=VSP_010340, VSP_010325; Name=5; IsoId=Q9BRR9-5; Sequence=VSP_010325, VSP_046391; Note=No experimental confirmation available.; 


uniprotID: Q7Z7H8
geneSymbol: MRPL10
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 261
go: ENSG00000159111;
snps: rs11538868
name:
39S ribosomal protein L10, mitochondrial (L10mt) (MRP-L10) (39S ribosomal protein L8, mitochondrial) (L8mt) (MRP-L8) (Mitochondrial large ribosomal subunit protein uL10m)

sequence:

opentargets:
large ribosomal subunit [GO:0015934]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; ribosome biogenesis [GO:0042254]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z7H8-1; Sequence=Displayed; Name=2; IsoId=Q7Z7H8-2; Sequence=VSP_044481; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: Q96A35
geneSymbol: MRPL24
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 216
go: ENSG00000143314;
name:
39S ribosomal protein L24, mitochondrial (L24mt) (MRP-L24) (Mitochondrial large ribosomal subunit protein uL24m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: Q6ZS11
geneSymbol: RINL
reactome: R-HSA-8876198;
name: Ras and Rab interactor-like protein
length: 566
go: ENSG00000187994;
snps: rs8110393
location: SUBCELLULAR LOCATION: Cell projection, ruffle {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasmic vesicle [GO:0031410]; ruffle [GO:0001726]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; endocytosis [GO:0006897]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZS11-1; Sequence=Displayed; Name=2; IsoId=Q6ZS11-2; Sequence=VSP_046909; Note=No experimental confirmation available.; 


uniprotID: Q13671
geneSymbol: RIN1
reactome: R-HSA-8876198;
name: Ras and Rab interactor 1 (Ras inhibitor JC99) (Ras interaction/interference protein 1)
length: 783
go: ENSG00000174791;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendrite [GO:0030425]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; associative learning [GO:0008306]; endocytosis [GO:0006897]; memory [GO:0007613]; negative regulation of synaptic plasticity [GO:0031914]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=RIN1; IsoId=Q13671-1; Sequence=Displayed; Name=RIN1-delta; IsoId=Q13671-2; Sequence=VSP_004377; Note=Shows reduced ability to bind to Ras and 14-3-3 proteins.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11784866}. Membrane {ECO:0000269|PubMed:11784866}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11784866}. Note=Some amount is membrane-associated.


uniprotID: Q13084
geneSymbol: MRPL28
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;5OOL;5OOM;
length: 256
snps: rs3194151 rs11557302 rs13226
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
name:
39S ribosomal protein L28, mitochondrial (L28mt) (MRP-L28) (Melanoma antigen p15) (Melanoma-associated antigen recognized by T-lymphocytes) (Mitochondrial large ribosomal subunit protein bL28m)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q06587
geneSymbol: RING1
length: 406
go: ENSG00000204227;
reactome:
R-HSA-2559580;R-HSA-3108214;R-HSA-3899300;R-HSA-4551638;R-HSA-4570464;R-HSA-4655427;R-HSA-8939243;R-HSA-8943724;R-HSA-8953750;

name:
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]; ubiquitin-protein transferase activator activity [GO:0097027]; anterior/posterior pattern specification [GO:0009952]; camera-type eye morphogenesis [GO:0048593]; histone H2A monoubiquitination [GO:0035518]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q06587-1; Sequence=Displayed; Name=2; IsoId=Q06587-2; Sequence=VSP_017694; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.


uniprotID: Q6ZS17
geneSymbol: RIPOR1
name: Rho family-interacting cell polarization regulator 1
length: 1223
go: ENSG00000039523;
sequence:

opentargets:
cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; vesicle membrane [GO:0012506]; 14-3-3 protein binding [GO:0071889]; cellular response to chemokine [GO:1990869]; cellular response to starvation [GO:0009267]; establishment of Golgi localization [GO:0051683]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; positive regulation of cell migration [GO:0030335]; positive regulation of intracellular protein transport [GO:0090316]; protein localization to Golgi apparatus [GO:0034067]; response to wounding [GO:0009611]; Rho protein signal transduction [GO:0007266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZS17-1; Sequence=Displayed; Name=2; IsoId=Q6ZS17-2; Sequence=VSP_025903; Name=3; IsoId=Q6ZS17-3; Sequence=VSP_043315, VSP_025903; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZS17-4; Sequence=VSP_045002, VSP_025903; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:27807006}. Note=Localizes to the podocyte major processes and cell body (By similarity). Colocalized with STK26 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with STK26 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000250|UniProtKB:Q68FE6, ECO:0000269|PubMed:27807006}.


uniprotID: Q9Y4F9
geneSymbol: RIPOR2
name: Rho family-interacting cell polarization regulator 2
length: 1068
go: ENSG00000111913;
snps: rs11967003 rs35331811 rs34016544 rs34298086 rs35514577 rs35780910 rs9461073
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; filopodium [GO:0030175]; stereocilium [GO:0032420]; stereocilium membrane [GO:0060171]; 14-3-3 protein binding [GO:0071889]; identical protein binding [GO:0042802]; auditory receptor cell stereocilium organization [GO:0060088]; cell adhesion [GO:0007155]; cellular response to chemokine [GO:1990869]; cellular response to mechanical stimulus [GO:0071260]; chemotaxis [GO:0006935]; establishment of protein localization [GO:0045184]; negative regulation of cell adhesion [GO:0007162]; negative regulation of establishment of T cell polarity [GO:1903904]; negative regulation of protein localization to cell leading edge [GO:1905872]; negative regulation of Rho guanyl-nucleotide exchange factor activity [GO:2001107]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of T cell migration [GO:2000405]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of filopodium assembly [GO:0051491]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of neutrophil extravasation [GO:2000391]; protein homooligomerization [GO:0051260]; regulation of establishment of cell polarity [GO:2000114]; regulation of mitotic spindle assembly [GO:1901673]; sensory perception of sound [GO:0007605]; skeletal muscle fiber development [GO:0048741]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y4F9-1; Sequence=Displayed; Name=2; Synonyms=PL48 {ECO:0000303|PubMed:9055809}; IsoId=Q9Y4F9-2; Sequence=VSP_025904, VSP_025905, VSP_025906; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17150207}. Cell projection, filopodium {ECO:0000269|PubMed:17150207}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80U16}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q7TP54}. Apical cell membrane {ECO:0000250|UniProtKB:Q7TP54}. Note=Localized in the cytoplasm in cells undergoing mitosis (PubMed:17150207). Colocalized with F-actin (PubMed:17150207). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (By similarity). Detected in punctate pattern forming a circumferential ring at the stereocilia base (By similarity). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-associated protein in stereocilia (By similarity). {ECO:0000250|UniProtKB:Q7TP54, ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207}.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm {ECO:0000269|PubMed:24687993}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:25588844}. Note=Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner (PubMed:25588844). {ECO:0000269|PubMed:25588844}.


uniprotID: Q96EL3
geneSymbol: MRPL53
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 112
snps: rs1047911
name:
39S ribosomal protein L53, mitochondrial (L53mt) (MRP-L53) (Mitochondrial large ribosomal subunit protein mL53)

sequence:
MAAALARLGLRPVKQVRVQFCPFEKNVESTRTFLQTVSSEKVRSTNLNCSVIADVRHDGSEPCVDVLFGDGHRLIMRGAHLTALEMLTAFASHIRARDAAGSGDKPGADTGR

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: P31350
geneSymbol: RRM2
reactome: R-HSA-499943;R-HSA-539107;R-HSA-8953750;
pdb: 2UW2;3OLJ;3VPM;3VPN;3VPO;
length: 389
go: ENSG00000171848;
drug: DB00242;DB05260;DB05801;DB05003;DB05428;
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)

sequence:

opentargets:
cytosol [GO:0005829]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; negative regulation of G0 to G1 transition [GO:0070317]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P31350-1; Sequence=Displayed; Name=2; IsoId=P31350-2; Sequence=VSP_044917; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q96DM3
geneSymbol: RMC1
length: 657
go: ENSG00000141452;
name:
Regulator of MON1-CCZ1 complex (Colon cancer-associated protein Mic1) (Mic-1) (WD repeat-containing protein 98)

sequence:

opentargets:
late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; Mon1-Ccz1 complex [GO:0035658]; autophagy [GO:0006914]; regulation of autophagy [GO:0010506]

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319}. Late endosome membrane {ECO:0000269|PubMed:29038162}.


uniprotID: Q96DB5
geneSymbol: RMDN1
name: Regulator of microtubule dynamics protein 1 (RMD-1) (hRMD-1) (Protein FAM82B)
length: 314
go: ENSG00000176623;
opentargets: cytoplasm [GO:0005737]; microtubule [GO:0005874]; spindle pole [GO:0000922]
snps: rs6980476
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96DB5-1; Sequence=Displayed; Name=2; IsoId=Q96DB5-2; Sequence=VSP_054647; Note=No experimental confirmation available.; Name=3; IsoId=Q96DB5-3; Sequence=VSP_054647, VSP_055727; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.


uniprotID: Q96LZ7
geneSymbol: RMDN2
name: Regulator of microtubule dynamics protein 2 (RMD-2) (hRMD-2) (Protein FAM82A1)
length: 410
go: ENSG00000115841;
snps: rs4670800
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; microtubule [GO:0005874]; mitotic spindle [GO:0072686]; spindle pole [GO:0000922]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96LZ7-1; Sequence=Displayed; Name=2; IsoId=Q96LZ7-2; Sequence=VSP_025524, VSP_025527; Name=3; IsoId=Q96LZ7-3; Sequence=VSP_025525, VSP_025526; Note=No experimental confirmation available.; Name=4; IsoId=Q96LZ7-4; Sequence=VSP_025525; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. Also detected as large dots in the perinuclear region.


uniprotID: Q9H9A7
geneSymbol: RMI1
pdb: 3MXN;3NBH;3NBI;4CGY;4CHT;4DAY;
name: RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75)
length: 625
go: ENSG00000178966;
snps: rs17855932 rs1982151
reactome:
R-HSA-5685938;R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;

sequence:

opentargets:
nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; RecQ helicase-Topo III complex [GO:0031422]; nucleotide binding [GO:0000166]; DNA replication [GO:0006260]; double-strand break repair via homologous recombination [GO:0000724]; glucose homeostasis [GO:0042593]; multicellular organism growth [GO:0035264]; reduction of food intake in response to dietary excess [GO:0002023]; resolution of meiotic recombination intermediates [GO:0000712]; response to glucose [GO:0009749]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15775963}. Note=Forms foci in response to DNA damage.


uniprotID: Q8N7X1
geneSymbol: RBMXL3
name: RNA-binding motif protein, X-linked-like-3
length: 1067
go: ENSG00000175718;
sequence:

opentargets:
commitment complex [GO:0000243]; mRNA binding [GO:0003729]; mRNA splicing, via spliceosome [GO:0000398]


uniprotID: Q9Y4L5
geneSymbol: RNF115
reactome: R-HSA-983168;
length: 304
go: ENSG00000265491;
snps: rs11577731
name:
E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rabring 7) (Zinc finger protein 364)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9D0C1}. Note=The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q9D0C1}.


uniprotID: Q9H920
geneSymbol: RNF121
name: RING finger protein 121
length: 327
go: ENSG00000137522;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; endoplasmic reticulum unfolded protein response [GO:0030968]; ubiquitin-dependent ERAD pathway [GO:0030433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H920-1; Sequence=Displayed; Name=2; IsoId=Q9H920-2; Sequence=VSP_054133; Note=No experimental confirmation available.; 


uniprotID: Q9H9V4
geneSymbol: RNF122
name: RING finger protein 122
length: 155
go: ENSG00000133874;
sequence:
MHPFQWCNGCFCGLGLVSTNKSCSMPPISFQDLPLNIYMVIFGTGIFVFMLSLIFCCYFISKLRNQAQSERYGYKEVVLKGDAKKLQLYGQTCAVCLEDFKGKDELGVLPCQHAFHRKCLVKWLEVRCVCPMCNKPIASPSEATQNIGILLDELV

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]

location:
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16778963}. Endoplasmic reticulum {ECO:0000269|PubMed:16778963}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.


uniprotID: Q5XPI4
geneSymbol: RNF123
reactome: R-HSA-5689880;R-HSA-983168;
pdb: 2MA6;
length: 1314
go: ENSG00000164068;
snps: rs2960546 rs35620248 rs35726701 rs34823813
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15531880}.
name:
E3 ubiquitin-protein ligase RNF123 (EC 2.3.2.27) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123) (RING-type E3 ubiquitin transferase RNF123)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein deubiquitination [GO:0016579]; proteolysis involved in cellular protein catabolic process [GO:0051603]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5XPI4-1; Sequence=Displayed; Name=2; IsoId=Q5XPI4-2; Sequence=VSP_020650; 


uniprotID: Q96EQ8
geneSymbol: RNF125
reactome: R-HSA-936440;
pdb: 5DKA;
length: 232
go: ENSG00000101695;
snps: rs786201014 rs373764886 rs370242930
name:
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)

sequence:

opentargets:
Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; p53 binding [GO:0002039]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17990982}; Lipid-anchor {ECO:0000269|PubMed:17990982}. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. {ECO:0000269|PubMed:17990982}.


uniprotID: Q9BV68
geneSymbol: RNF126
reactome: R-HSA-983168;
pdb: 2N9O;2N9P;
name: E3 ubiquitin-protein ligase RNF126 (EC 2.3.2.27) (RING finger protein 126)
length: 326
go: ENSG00000070423;
snps: rs2285751
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; epidermal growth factor receptor binding [GO:0005154]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; cytoplasm protein quality control by the ubiquitin-proteasome system [GO:0071629]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; regulation of cell proliferation [GO:0042127]; retrograde transport, endosome to Golgi [GO:0042147]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BV68-1; Sequence=Displayed; Name=2; IsoId=Q9BV68-2; Sequence=VSP_015693, VSP_015694; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.


uniprotID: Q8WU17
geneSymbol: RNF139
reactome: R-HSA-901032;
length: 664
go: ENSG00000170881;
name:
E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)

sequence:

opentargets:
Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; integral component of membrane [GO:0016021]; ligase activity [GO:0016874]; protease binding [GO:0002020]; signaling receptor activity [GO:0038023]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein transferase activity [GO:0019787]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; negative regulation of cell proliferation [GO:0008285]; negative regulation of translation [GO:0017148]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein destabilization [GO:0031648]; protein ubiquitination [GO:0016567]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of protein processing [GO:0070613]; regulation of protein ubiquitination [GO:0031396]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.


uniprotID: Q8WVD5
geneSymbol: RNF141
pdb: 2ECN;5XEK;
name: RING finger protein 141 (Zinc finger protein 230)
length: 230
go: ENSG00000110315;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
sequence:

opentargets:
membrane [GO:0016020]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Short; IsoId=Q8WVD5-1; Sequence=Displayed; Name=2; Synonyms=Long; IsoId=Q8WVD5-2; Sequence=Not described; 


uniprotID: Q96MT1
geneSymbol: RNF145
name: RING finger protein 145 (EC 2.3.2.27)
length: 663
go: ENSG00000145860;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; transferase activity [GO:0016740]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96MT1-1; Sequence=Displayed; Name=2; IsoId=Q96MT1-2; Sequence=VSP_037501; Name=3; IsoId=Q96MT1-3; Sequence=VSP_043661; Note=No experimental confirmation available.; Name=4; IsoId=Q96MT1-4; Sequence=VSP_043662; Note=No experimental confirmation available.; Name=5; IsoId=Q96MT1-5; Sequence=VSP_044539; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5SWK7}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9NTX7
geneSymbol: RNF146
reactome: R-HSA-201681;R-HSA-4641257;R-HSA-5689880;R-HSA-8948751;
pdb: 2D8T;3V3L;6CF6;
length: 359
go: ENSG00000118518;
snps: rs10081141
name:
E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; poly-ADP-D-ribose binding [GO:0072572]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NTX7-1; Sequence=Displayed; Name=2; IsoId=Q9NTX7-2; Sequence=VSP_012968; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.


uniprotID: Q9HB40
geneSymbol: SCPEP1
name: Retinoid-inducible serine carboxypeptidase (EC 3.4.16.-) (Serine carboxypeptidase 1)
length: 452
go: ENSG00000121064;
drug: DB07506;
snps: rs34108204 rs16957938
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; serine-type carboxypeptidase activity [GO:0004185]; negative regulation of blood pressure [GO:0045776]; positive regulation of blood vessel diameter [GO:0097755]; proteolysis involved in cellular protein catabolic process [GO:0051603]; retinoic acid metabolic process [GO:0042573]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HB40-1; Sequence=Displayed; Name=2; IsoId=Q9HB40-2; Sequence=VSP_008555, VSP_008556; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q92963
geneSymbol: RIT1
reactome: R-HSA-187706;
pdb: 4KLZ;
length: 219
go: ENSG00000143622;
location: SUBCELLULAR LOCATION: Cell membrane.
name:
GTP-binding protein Rit1 (Ras-like protein expressed in many tissues) (Ras-like without CAAX protein 1)

sequence:

opentargets:
intracellular [GO:0005622]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Ras protein signal transduction [GO:0007265]; signal transduction [GO:0007165]

snps:
rs869025189 rs672601334 rs869025193 rs730881014 rs869025194 rs869025195 rs869025197 rs483352822 rs672601335 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q92963-1; Sequence=Displayed; Name=2; IsoId=Q92963-2; Sequence=VSP_045306; Name=3; IsoId=Q92963-3; Sequence=VSP_047114; Note=No experimental confirmation available.; 


uniprotID: Q99578
geneSymbol: RIT2
reactome: R-HSA-187706;
name: GTP-binding protein Rit2 (Ras-like protein expressed in neurons) (Ras-like without CAAX protein 2)
length: 217
go: ENSG00000152214;
sequence:

opentargets:
cell body [GO:0044297]; cytoplasm [GO:0005737]; dendritic tree [GO:0097447]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; chromatin binding [GO:0003682]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; semaphorin receptor binding [GO:0030215]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; chemical synaptic transmission [GO:0007268]; intracellular signal transduction [GO:0035556]; maintenance of protein location in cell [GO:0032507]; negative regulation of neuron projection development [GO:0010977]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuron projection development [GO:0010976]; positive regulation of transcription by RNA polymerase II [GO:0045944]; Ras protein signal transduction [GO:0007265]; regulation of calcium-mediated signaling [GO:0050848]; regulation of Cdc42 protein signal transduction [GO:0032489]; regulation of endocytosis [GO:0030100]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99578-1; Sequence=Displayed; Name=2; Synonyms=RIBA; IsoId=Q99578-2; Sequence=VSP_018102, VSP_018103; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12934100, ECO:0000269|PubMed:16122393}. Cell membrane {ECO:0000269|PubMed:16122393}. Note=Colocalizes with PLXNB3 at the plasma membrane (PubMed:16122393). {ECO:0000269|PubMed:16122393}.


uniprotID: Q9ULK6
geneSymbol: RNF150
name: RING finger protein 150
length: 438
go: ENSG00000170153;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9ULK6-1; Sequence=Displayed; Name=2; IsoId=Q9ULK6-2; Sequence=VSP_023845; Note=No experimental confirmation available.; Name=3; IsoId=Q9ULK6-3; Sequence=VSP_023846, VSP_023847; Note=No experimental confirmation available.; Name=4; IsoId=Q9ULK6-4; Sequence=VSP_023843, VSP_023844; 


uniprotID: Q2KHN1
geneSymbol: RNF151
name: RING finger protein 151
length: 245
go: ENSG00000179580;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]


uniprotID: Q96K30
geneSymbol: RITA1
pdb: 5EG6;
name: RBPJ-interacting and tubulin-associated protein 1 (RBPJ-interacting and tubulin-associated protein)
length: 269
go: ENSG00000139405;
snps: rs16942601 rs34831139
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; tubulin binding [GO:0015631]; negative regulation of Notch signaling pathway [GO:0045746]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; nuclear export [GO:0051168]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96K30-1; Sequence=Displayed; Name=2; IsoId=Q96K30-2; Sequence=VSP_026636, VSP_026637; Note=No experimental confirmation available.; Name=3; IsoId=Q96K30-3; Sequence=VSP_055649; Note=No experimental confirmation available. Gene prediction based on partial EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.


uniprotID: Q96A37
geneSymbol: RNF166
name: RING finger protein 166
length: 237
go: ENSG00000158717;
opentargets: metal ion binding [GO:0046872]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96A37-1; Sequence=Displayed; Name=2; IsoId=Q96A37-2; Sequence=VSP_019750; Note=No experimental confirmation available.; Name=3; IsoId=Q96A37-3; Sequence=VSP_046147; Note=No experimental confirmation available.; 


uniprotID: Q8NCN4
geneSymbol: RNF169
pdb: 5GG4;5VEY;
length: 708
go: ENSG00000166439;
name:
E3 ubiquitin-protein ligase RNF169 (EC 2.3.2.27) (RING finger protein 169) (RING-type E3 ubiquitin transferase RNF169)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; transferase activity [GO:0016740]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of double-strand break repair [GO:2000780]; protein ubiquitination [GO:0016567]

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:22492721, ECO:0000269|PubMed:22733822, ECO:0000269|PubMed:22742833}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products.


uniprotID: Q96K19
geneSymbol: RNF170
length: 258
go: ENSG00000120925;
snps: rs397514478
name:
E3 ubiquitin-protein ligase RNF170 (EC 2.3.2.27) (Putative LAG1-interacting protein) (RING finger protein 170) (RING-type E3 ubiquitin transferase RNF170)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q96K19-1; Sequence=Displayed; Name=2; IsoId=Q96K19-2; Sequence=VSP_023856; Note=No experimental confirmation available.; Name=3; IsoId=Q96K19-3; Sequence=VSP_023855, VSP_023857; Note=No experimental confirmation available.; Name=4; IsoId=Q96K19-4; Sequence=VSP_023851, VSP_023852; Note=No experimental confirmation available.; Name=5; IsoId=Q96K19-5; Sequence=VSP_023853, VSP_023854; Note=No experimental confirmation available.; Name=6; IsoId=Q96K19-6; Sequence=VSP_044556; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21610068}; Multi-pass membrane protein {ECO:0000269|PubMed:21610068}.


uniprotID: Q8N4F7
geneSymbol: RNF175
name: RING finger protein 175
length: 328
go: ENSG00000145428;
snps: rs10517577 rs1337 rs1339 rs2405432
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; endoplasmic reticulum unfolded protein response [GO:0030968]; ubiquitin-dependent ERAD pathway [GO:0030433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N4F7-1; Sequence=Displayed; Name=2; IsoId=Q8N4F7-2; Sequence=VSP_055433, VSP_055434, VSP_055435, VSP_055436; Note=No experimental confirmation available.; 


uniprotID: Q9P0P0
geneSymbol: RNF181
reactome: R-HSA-8866654;
length: 153
go: ENSG00000168894;
snps: rs6643
name:
E3 ubiquitin-protein ligase RNF181 (EC 2.3.2.27) (RING finger protein 181) (RING-type E3 ubiquitin transferase RNF181)

sequence:
MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVENLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYELPTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT

opentargets:
cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; protein ubiquitination [GO:0016567]


uniprotID: Q8N6D2
geneSymbol: RNF182
reactome: R-HSA-983168;
length: 247
go: ENSG00000180537;
name:
E3 ubiquitin-protein ligase RNF182 (EC 2.3.2.27) (RING finger protein 182) (RING-type E3 ubiquitin transferase RNF182)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:18298843}.


uniprotID: Q96GF1
geneSymbol: RNF185
reactome: R-HSA-382556;R-HSA-5678895;R-HSA-901032;
length: 192
go: ENSG00000138942;
name:
E3 ubiquitin-protein ligase RNF185 (EC 2.3.2.27) (RING finger protein 185) (RING-type E3 ubiquitin transferase RNF185)

sequence:
MASKGPSASASPENSSAGGPSGSSNGAGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA

opentargets:
Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; integral component of membrane [GO:0016021]; mitochondrial outer membrane [GO:0005741]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; autophagy [GO:0006914]; endoplasmic reticulum mannose trimming [GO:1904380]; ER-associated misfolded protein catabolic process [GO:0071712]; ERAD pathway [GO:0036503]; protein autoubiquitination [GO:0051865]; transmembrane transport [GO:0055085]; ubiquitin-dependent ERAD pathway [GO:0030433]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GF1-1; Sequence=Displayed; Name=2; IsoId=Q96GF1-2; Sequence=VSP_020004; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:21931693}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24019521, ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q6ZMZ0
geneSymbol: RNF19B
reactome: R-HSA-983168;
length: 732
go: ENSG00000116514;
name:
E3 ubiquitin-protein ligase RNF19B (EC 2.3.2.31) (IBR domain-containing protein 3) (Natural killer lytic-associated molecule) (RING finger protein 19B)

sequence:

opentargets:
cytolytic granule [GO:0044194]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; adaptive immune response [GO:0002250]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZMZ0-1; Sequence=Displayed; Name=2; IsoId=Q6ZMZ0-2; Sequence=VSP_028635, VSP_028633, VSP_028634; Name=3; IsoId=Q6ZMZ0-3; Sequence=VSP_028632, VSP_028635, VSP_028633, VSP_028634; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZMZ0-4; Sequence=VSP_028635; 

location:
SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000269|PubMed:10438909}; Multi-pass membrane protein {ECO:0000269|PubMed:10438909}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q92730
geneSymbol: RND1
reactome: R-HSA-399955;R-HSA-416550;R-HSA-416572;
pdb: 2CLS;2REX;3Q3J;
name: Rho-related GTP-binding protein Rho6 (Rho family GTPase 1) (Rnd1)
length: 232
go: ENSG00000172602;
snps: rs2270577
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; adherens junction [GO:0005912]; cell cortex [GO:0005938]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; negative regulation of cell adhesion [GO:0007162]; neuron remodeling [GO:0016322]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11940653}; Lipid-anchor {ECO:0000269|PubMed:11940653}; Cytoplasmic side {ECO:0000269|PubMed:11940653}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11940653}.


uniprotID: Q8N5U6
geneSymbol: RNF10
name: RING finger protein 10
length: 811
go: ENSG00000022840;
snps: rs17852961 rs16950277
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of Schwann cell proliferation [GO:0010626]; positive regulation of myelination [GO:0031643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autoubiquitination [GO:0051865]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N5U6-1; Sequence=Displayed; Name=2; IsoId=Q8N5U6-2; Sequence=VSP_021478; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16335786}. Nucleus {ECO:0000250|UniProtKB:Q5XI59}.


uniprotID: Q96EP0
geneSymbol: RNF31
reactome: R-HSA-5357905;R-HSA-5357956;
pdb: 2CT7;4DBG;4JUY;4LJO;4LJP;4LJQ;4OWF;4OYJ;4OYK;4P09;4P0A;4P0B;5EDV;5LJN;5X0W;
length: 1072
go: ENSG00000092098;
snps: rs2277484
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q924T7}.
name:
E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)

sequence:

opentargets:
CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]; metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; CD40 signaling pathway [GO:0023035]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein linear polyubiquitination [GO:0097039]; protein polyubiquitination [GO:0000209]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; T cell receptor signaling pathway [GO:0050852]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96EP0-1; Sequence=Displayed; Name=2; IsoId=Q96EP0-2; Sequence=VSP_009647, VSP_009648; Note=No experimental confirmation available.; Name=3; IsoId=Q96EP0-3; Sequence=VSP_014006, VSP_014007; 


uniprotID: Q9H0A6
geneSymbol: RNF32
name: RING finger protein 32
length: 362
go: ENSG00000105982;
opentargets: aggresome [GO:0016235]; endosome [GO:0005768]; metal ion binding [GO:0046872]
snps: rs2302148 rs2302147 rs2302146
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11890671}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Other isoforms seem to exist.; Name=1; IsoId=Q9H0A6-1; Sequence=Displayed; Name=2; IsoId=Q9H0A6-2; Sequence=VSP_019740; Note=Derived from EST data.; Name=3; IsoId=Q9H0A6-4; Sequence=VSP_019743, VSP_019744; Name=4; IsoId=Q9H0A6-5; Sequence=VSP_019741; Note=No experimental confirmation available.; Name=5; IsoId=Q9H0A6-6; Sequence=VSP_019738, VSP_019739; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q96EX2
geneSymbol: RNFT2
name: RING finger and transmembrane domain-containing protein 2 (Transmembrane protein 118)
length: 444
go: ENSG00000135119;
opentargets: integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96EX2-1; Sequence=Displayed; Name=2; IsoId=Q96EX2-2; Sequence=VSP_023465, VSP_023466; Note=No experimental confirmation available.; Name=3; IsoId=Q96EX2-3; Sequence=VSP_035514, VSP_035515, VSP_035516; Note=No experimental confirmation available.; Name=4; IsoId=Q96EX2-4; Sequence=VSP_035513; Note=No experimental confirmation available.; Name=5; IsoId=Q96EX2-5; Sequence=VSP_035515, VSP_035516; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q15286
geneSymbol: RAB35
reactome: R-HSA-8854214;R-HSA-8873719;R-HSA-8876198;
pdb: 3TW8;
name: Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C)
length: 201
go: ENSG00000111737;
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; cell projection membrane [GO:0031253]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; intercellular bridge [GO:0045171]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; antigen processing and presentation [GO:0019882]; cellular response to nerve growth factor stimulus [GO:1990090]; endocytic recycling [GO:0032456]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; mitotic cytokinesis [GO:0000281]; neuron projection development [GO:0031175]; plasma membrane to endosome transport [GO:0048227]; protein localization [GO:0008104]; protein localization to endosome [GO:0036010]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15286-1; Sequence=Displayed; Name=2; IsoId=Q15286-2; Sequence=VSP_042918; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:16950109}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16950109}. Endosome {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:21951725}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Present on sorting endosomes and recycling endosome tubules (PubMed:16950109). Tends to be enriched in PIP2-positive cell membrane domains (PubMed:16950109). During mitosis, associated with the plasma membrane and present at the ingressing furrow during early cytokinesis as well as at the intercellular bridge later during cytokinesis (PubMed:16950109). Identified in stage I to stage IV melanosomes (PubMed:17081065). {ECO:0000269|PubMed:16950109, ECO:0000269|PubMed:17081065}.


uniprotID: Q9ULW5
geneSymbol: RAB26
reactome: R-HSA-8873719;
pdb: 2G6B;
name: Ras-related protein Rab-26
length: 256
go: ENSG00000167964;
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; Golgi membrane [GO:0000139]; intrinsic component of plasma membrane [GO:0031226]; secretory granule membrane [GO:0030667]; GMP binding [GO:0019002]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; exocrine system development [GO:0035272]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]; regulated exocytosis [GO:0045055]; regulation of exocytosis [GO:0017157]; regulation of protein catabolic process at presynapse, modulating synaptic transmission [GO:0099575]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULW5-1; Sequence=Displayed; Name=2; IsoId=Q9ULW5-2; Sequence=VSP_056879; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23105096}; Lipid-anchor {ECO:0000269|PubMed:23105096}; Cytoplasmic side {ECO:0000269|PubMed:23105096}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:23105096}; Lipid-anchor {ECO:0000305|PubMed:23105096}; Cytoplasmic side {ECO:0000305|PubMed:23105096}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250|UniProtKB:P51156}.


uniprotID: P20339
geneSymbol: RAB5A
reactome: R-HSA-1660499;R-HSA-8854214;R-HSA-8856828;R-HSA-8873719;R-HSA-8876198;R-HSA-983231;
pdb: 1N6H;1N6I;1N6K;1N6L;1N6N;1N6O;1N6P;1N6R;1R2Q;1TU3;1TU4;3MJH;4Q9U;
name: Ras-related protein Rab-5A
length: 215
go: ENSG00000144566;
drug: DB04315;DB04137;DB02467;
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; anchored component of synaptic vesicle membrane [GO:0098993]; axon [GO:0030424]; axon terminus [GO:0043679]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; cytoplasmic side of early endosome membrane [GO:0098559]; cytosol [GO:0005829]; dendrite [GO:0030425]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; melanosome [GO:0042470]; membrane raft [GO:0045121]; neuronal cell body [GO:0043025]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; postsynaptic early endosome [GO:0098842]; ruffle [GO:0001726]; somatodendritic compartment [GO:0036477]; synaptic vesicle [GO:0008021]; terminal bouton [GO:0043195]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; blood coagulation [GO:0007596]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of exocytosis [GO:0045921]; post-translational protein modification [GO:0043687]; Rab protein signal transduction [GO:0032482]; receptor internalization involved in canonical Wnt signaling pathway [GO:2000286]; regulation of autophagosome assembly [GO:2000785]; regulation of endocytosis [GO:0030100]; regulation of endosome size [GO:0051036]; regulation of filopodium assembly [GO:0051489]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of synaptic vesicle exocytosis [GO:2000300]; synaptic vesicle recycling [GO:0036465]; transcytosis [GO:0045056]; viral RNA genome replication [GO:0039694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P20339-1; Sequence=Displayed; Name=2; IsoId=P20339-2; Sequence=VSP_055830; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23815289}; Lipid-anchor {ECO:0000305|PubMed:7991565}; Cytoplasmic side {ECO:0000250|UniProtKB:P18066}. Early endosome membrane {ECO:0000269|PubMed:23815289, ECO:0000269|PubMed:25869668}; Lipid-anchor {ECO:0000305|PubMed:7991565}. Melanosome {ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000269|PubMed:10818110}. Cell projection, ruffle {ECO:0000250|UniProtKB:P18066}. Membrane {ECO:0000269|PubMed:23815289}. Cytoplasm, cytosol. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CQD1}. Endosome membrane {ECO:0000269|PubMed:22431521}. Note=Enriched in stage I melanosomes (PubMed:17081065). Alternates between membrane-bound and cytosolic forms (Probable). {ECO:0000269|PubMed:17081065, ECO:0000305}.


uniprotID: P15918
geneSymbol: RAG1
reactome: R-HSA-1266695;R-HSA-5687128;
length: 1043
go: ENSG00000166349;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00820}.
name:
V(D)J recombination-activating protein 1 (RAG-1) (RING finger protein 74) [Includes: Endonuclease RAG1 (EC 3.1.-.-); E3 ubiquitin-protein ligase RAG1 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RAG1)]

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; adaptive immune response [GO:0002250]; B cell differentiation [GO:0030183]; DNA recombination [GO:0006310]; histone monoubiquitination [GO:0010390]; immune response [GO:0006955]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of thymocyte apoptotic process [GO:0070244]; positive regulation of T cell differentiation [GO:0045582]; pre-B cell allelic exclusion [GO:0002331]; protein autoubiquitination [GO:0051865]; regulation of behavioral fear response [GO:2000822]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; V(D)J recombination [GO:0033151]; visual learning [GO:0008542]

snps:
rs1801203 rs4151027 rs199474683 rs4151029 rs3740955 rs4151030 rs121918568 rs121918571 rs773272902 rs104894289 rs104894291 rs104894291 rs199474682 rs199474684 rs104894292 rs199474679 rs141524540 rs199474685 rs4151031 rs199474677 rs199474678 rs199474686 rs104894298 rs193922461 rs4151032 rs199474681 rs104894285 rs104894284 rs199474688 rs199474680 rs199474689 rs199474676 rs28933392 rs104894286 rs199474687 rs121918569 rs2227973 rs104894287 rs199474690 rs4151033 rs199474691 rs4151034 rs104894290 rs150739647 rs121918570 rs104894288 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P15918-1; Sequence=Displayed; Name=2; IsoId=P15918-2; Sequence=VSP_055883; Note=No experimental confirmation available.; 


uniprotID: Q3YEC7
geneSymbol: RABL6
name: Rab-like protein 6 (GTP-binding protein Parf) (Partner of ARF) (Rab-like protein 1) (RBEL1)
length: 729
go: ENSG00000196642;
snps: rs2811741
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=RBEL1A; IsoId=Q3YEC7-1; Sequence=Displayed; Note=Predominant isoform. Overexpressed in about 67% of primary breast tumors.; Name=2; IsoId=Q3YEC7-2; Sequence=VSP_022646; Name=3; Synonyms=RBEL1B; IsoId=Q3YEC7-3; Sequence=VSP_022649; Note=No experimental confirmation available.; Name=4; Synonyms=RBEL1D; IsoId=Q3YEC7-4; Sequence=VSP_022647, VSP_022648; Name=5; IsoId=Q3YEC7-5; Sequence=VSP_022646, VSP_022647, VSP_022648; Name=6; Synonyms=RBEL1C; IsoId=Q3YEC7-6; Sequence=VSP_042559, VSP_042560; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm {ECO:0000269|PubMed:17962191}. Note=Predominantly cytoplasmic (PubMed:17962191).; SUBCELLULAR LOCATION: Isoform 3: Nucleus {ECO:0000269|PubMed:17962191}. Note=Predominantly nuclear (PubMed:17962191).


uniprotID: Q8IXT5
geneSymbol: RBM12B
name: RNA-binding protein 12B (RNA-binding motif protein 12B)
length: 1001
go: ENSG00000183808;
opentargets: RNA binding [GO:0003723]
snps: rs17853906 rs17857188 rs16916188
sequence:


uniprotID: Q14644
geneSymbol: RASA3
reactome: R-HSA-5658442;R-HSA-6802949;
name: Ras GTPase-activating protein 3 (GAP1(IP4BP)) (Ins P4-binding protein)
length: 834
go: ENSG00000185989;
location: SUBCELLULAR LOCATION: Cell membrane.
sequence:

opentargets:
cytosol [GO:0005829]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; calcium-release channel activity [GO:0015278]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; MAPK cascade [GO:0000165]; negative regulation of Ras protein signal transduction [GO:0046580]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14644-1; Sequence=Displayed; Name=2; IsoId=Q14644-2; Sequence=VSP_056141; Note=No experimental confirmation available.; 


uniprotID: Q8TBN0
geneSymbol: RAB3IL1
reactome: R-HSA-8876198;
pdb: 4LI0;
length: 382
go: ENSG00000167994;
snps: rs174477 rs3815045
name:
Guanine nucleotide exchange factor for Rab-3A (Rab-3A-interacting-like protein 1) (Rab3A-interacting-like protein 1) (Rabin3-like 1)

sequence:

opentargets:
cytosol [GO:0005829]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TBN0-1; Sequence=Displayed; Name=2; IsoId=Q8TBN0-2; Sequence=VSP_028344, VSP_028345; 


uniprotID: Q9BZG1
geneSymbol: RAB34
reactome: R-HSA-8873719;
name: Ras-related protein Rab-34 (Ras-related protein Rab-39) (Ras-related protein Rah)
length: 259
go: ENSG00000109113;
snps: rs12125
sequence:

opentargets:
cilium [GO:0005929]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi cisterna [GO:0031985]; Golgi stack [GO:0005795]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTP-dependent protein binding [GO:0030742]; GTPase activity [GO:0003924]; Ral GTPase binding [GO:0017160]; antigen processing and presentation [GO:0019882]; cell projection organization [GO:0030030]; Golgi to plasma membrane protein transport [GO:0043001]; intracellular protein transport [GO:0006886]; lysosome localization [GO:0032418]; phagosome maturation [GO:0090382]; phagosome-lysosome fusion [GO:0090385]; positive regulation of smoothened signaling pathway [GO:0045880]; protein localization to plasma membrane [GO:0072659]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9BZG1-1; Sequence=Displayed; Name=2; IsoId=Q9BZG1-2; Sequence=VSP_010142; Name=NARR; IsoId=P0DI83-1; Sequence=External; Name=4; IsoId=Q9BZG1-4; Sequence=VSP_044734; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64008}. Golgi apparatus {ECO:0000250|UniProtKB:Q64008}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid-anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Cell projection, cilium {ECO:0000250|UniProtKB:Q64008}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269|PubMed:21255211}.


uniprotID: O43502
geneSymbol: RAD51C
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693616;R-HSA-912446;R-HSA-983231;
name: DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)
length: 376
go: ENSG00000108384;
sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]; ATP binding [GO:0005524]; crossover junction endodeoxyribonuclease activity [GO:0008821]; DNA binding [GO:0003677]; DNA-dependent ATPase activity [GO:0008094]; blood coagulation [GO:0007596]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; female meiosis sister chromatid cohesion [GO:0007066]; male meiosis I [GO:0007141]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; reciprocal meiotic recombination [GO:0007131]; sister chromatid cohesion [GO:0007062]; spermatogenesis [GO:0007283]; telomere maintenance via recombination [GO:0000722]

snps:
rs376403182 rs730881927 rs267606998 rs61758784 rs267606999 rs28363307 rs35151472 rs587780256 rs587780838 rs28363311 rs267606997 rs149331537 rs147241704 rs28363317 rs577852020 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43502-1; Sequence=Displayed; Name=2; IsoId=O43502-2; Sequence=VSP_043656, VSP_043657; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA.


uniprotID: O75771
geneSymbol: RAD51D
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693616;R-HSA-6796648;
pdb: 2KZ3;
name: DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)
length: 328
go: ENSG00000185379;
snps: rs140825795 rs28363257 rs4796033 rs28363282 rs28363283 rs28363284
sequence:

opentargets:
centrosome [GO:0005813]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; nuclear chromosome, telomeric region [GO:0000784]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent ATPase activity [GO:0008094]; gamma-tubulin binding [GO:0043015]; single-stranded DNA binding [GO:0003697]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; reciprocal meiotic recombination [GO:0007131]; regulation of cell cycle [GO:0051726]; strand invasion [GO:0042148]; telomere maintenance [GO:0000723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; Synonyms=TRAD; IsoId=O75771-1; Sequence=Displayed; Name=2; Synonyms=TRAD-D1, D2; IsoId=O75771-2; Sequence=VSP_005558, VSP_005559; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=TRAD-D3; IsoId=O75771-3; Sequence=VSP_005560; Name=4; Synonyms=TRAD-D4; IsoId=O75771-4; Sequence=VSP_005561; Name=5; Synonyms=TRAD-D5; IsoId=O75771-5; Sequence=VSP_005562; Name=6; Synonyms=TRAD-D6, D7; IsoId=O75771-6; Sequence=VSP_005563, VSP_005564; Name=7; Synonyms=TRAD-D8; IsoId=O75771-7; Sequence=VSP_005565, VSP_005566; Name=8; IsoId=O75771-8; Sequence=VSP_043658; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.


uniprotID: Q9ULC3
geneSymbol: RAB23
reactome: R-HSA-8873719;
name: Ras-related protein Rab-23
length: 237
go: ENSG00000112210;
snps: rs45442500 rs45479896 rs1040461
sequence:

opentargets:
autophagosome [GO:0005776]; cell junction [GO:0030054]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; autophagosome assembly [GO:0000045]; cellular defense response [GO:0006968]; cilium assembly [GO:0060271]; craniofacial suture morphogenesis [GO:0097094]; GTP metabolic process [GO:0046039]; intracellular protein transport [GO:0006886]; negative regulation of protein import into nucleus [GO:0042308]; Rab protein signal transduction [GO:0032482]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35288}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:P35288}. Cytoplasm {ECO:0000269|PubMed:22365972}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22452336}. Endosome membrane {ECO:0000250, ECO:0000250|UniProtKB:P35288}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.


uniprotID: A0A096LP55
geneSymbol: UQCRHL
name: Cytochrome b-c1 complex subunit 6-like, mitochondrial
sequence: MGLEDEQKMLTESGDPEEEEEEEEELVDPLTTVREQCEQLEKCVKARERLELYDEHVSSRSHTEEDCTEELFDFLHAKDHCVAHKLFNNLK
length: 91
go: ENSG00000233954;
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00127}.
opentargets:
mitochondrial respiratory chain complex III [GO:0005750]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; aerobic respiration [GO:0009060]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]


uniprotID: Q9BTL3
geneSymbol: RAMAC
pdb: 5E8J;
length: 118
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22099306}.
name:
RNA guanine-N7 methyltransferase activating subunit (Protein FAM103A1) (RNA guanine-7 methyltransferase activating subunit) (RNMT-activating mRNA cap methyltransferase subunit) (RNMT-activating mini protein) (RAM)

sequence:
MTDTAEAVPKFEEMFASRFTENDKEYQEYLKRPPESPPIVEEWNSRAGGNQRNRGNRLQDNRQFRGRDNRWGWPSDNRSNQWHGRSWGNNYPQHRQEPYYPQQYGHYGYNQRPPYGYY

opentargets:
mRNA cap binding complex [GO:0005845]; mRNA cap methyltransferase complex [GO:0031533]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; 7-methylguanosine mRNA capping [GO:0006370]; methylation [GO:0032259]; recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex [GO:0036031]; RNA 5'-cap (guanine-N7)-methylation [GO:0106005]


uniprotID: O60895
geneSymbol: RAMP2
reactome: R-HSA-418555;R-HSA-419812;
pdb: 2XVT;3AQE;3AQF;4RWF;
length: 175
go: ENSG00000131477;
drug: DB01278;
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Receptor activity-modifying protein 2 (Calcitonin-receptor-like receptor activity-modifying protein 2) (CRLR activity-modifying protein 2)

sequence:
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA

opentargets:
adrenomedullin receptor complex [GO:1903143]; amylin receptor complex 2 [GO:0150057]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; adrenomedullin binding [GO:1990409]; adrenomedullin receptor activity [GO:0001605]; coreceptor activity [GO:0015026]; protein transporter activity [GO:0008565]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; adherens junction assembly [GO:0034333]; adrenomedullin receptor signaling pathway [GO:1990410]; amylin receptor signaling pathway [GO:0097647]; angiogenesis [GO:0001525]; basement membrane assembly [GO:0070831]; bicellular tight junction assembly [GO:0070830]; calcium ion transport [GO:0006816]; cellular response to hormone stimulus [GO:0032870]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; female pregnancy [GO:0007565]; G protein-coupled receptor signaling pathway [GO:0007186]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of vascular permeability [GO:0043116]; positive regulation of angiogenesis [GO:0045766]; positive regulation of gene expression [GO:0010628]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; protein transport [GO:0015031]; receptor internalization [GO:0031623]; regulation of blood pressure [GO:0008217]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to estradiol [GO:0032355]; response to hypoxia [GO:0001666]; response to progesterone [GO:0032570]; sprouting angiogenesis [GO:0002040]; vascular smooth muscle cell development [GO:0097084]; vasculogenesis [GO:0001570]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60895-1; Sequence=Displayed; Name=2; IsoId=O60895-2; Sequence=VSP_055838; 


uniprotID: Q9NYN1
geneSymbol: RASL12
pdb: 3C5C;
name: Ras-like protein family member 12 (Ras-like protein Ris)
length: 266
go: ENSG00000103710;
sequence:

opentargets:
membrane [GO:0016020]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NYN1-1; Sequence=Displayed; Name=2; IsoId=Q9NYN1-2; Sequence=VSP_055845; Note=No experimental confirmation available.; Name=3; IsoId=Q9NYN1-3; Sequence=VSP_055846; Note=No experimental confirmation available.; 


uniprotID: Q9NTZ6
geneSymbol: RBM12
pdb: 1WEL;2CPY;2DNN;2EK1;2EK6;
length: 932
go: ENSG00000244462;
opentargets: nucleoplasm [GO:0005654]; RNA binding [GO:0003723]
snps: rs17092928 rs6121012
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.
name:
RNA-binding protein 12 (RNA-binding motif protein 12) (SH3/WW domain anchor protein in the nucleus) (SWAN)

sequence:


uniprotID: P20338
geneSymbol: RAB4A
reactome: R-HSA-1445148;R-HSA-1660499;R-HSA-8854214;R-HSA-8873719;R-HSA-8875656;
pdb: 1YU9;1Z0K;2BMD;2BME;
name: Ras-related protein Rab-4A
length: 218
go: ENSG00000168118;
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; insulin-responsive compartment [GO:0032593]; intracellular membrane-bounded organelle [GO:0043231]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; vesicle [GO:0031982]; ATPase activator activity [GO:0001671]; ATPase binding [GO:0051117]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ionotropic glutamate receptor binding [GO:0035255]; protein transporter activity [GO:0008565]; syntaxin binding [GO:0019905]; antigen processing and presentation [GO:0019882]; intracellular protein transport [GO:0006886]; phosphatidylinositol biosynthetic process [GO:0006661]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]

location:
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:1425574}. Cytoplasm {ECO:0000269|PubMed:1425574}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000269|PubMed:1425574}.


uniprotID: P10114
geneSymbol: RAP2A
pdb: 1KAO;2RAP;3RAP;
name: Ras-related protein Rap-2a (RbBP-30)
length: 183
go: ENSG00000125249;
drug: DB04315;DB04137;
sequence:
MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ

opentargets:
cytosol [GO:0005829]; midbody [GO:0030496]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; magnesium ion binding [GO:0000287]; actin cytoskeleton reorganization [GO:0031532]; cellular protein localization [GO:0034613]; cellular response to drug [GO:0035690]; establishment of protein localization [GO:0045184]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of dendrite morphogenesis [GO:0048814]; regulation of JNK cascade [GO:0046328]

location:
SUBCELLULAR LOCATION: Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Midbody. Note=May also localize to the Golgi (PubMed:7962206) and the gelatinase-containing granules of neutrophils (PubMed:8391995). Colocalizes with RASGEF1B to midbody at telophase (PubMed:23894443). {ECO:0000269|PubMed:23894443, ECO:0000269|PubMed:7962206, ECO:0000269|PubMed:8391995}.


uniprotID: A6NC62
geneSymbol: RBAKDN
name: Putative RBAK downstream neighbor protein
length: 111
sequence:
MLTPRKAFRTCSKESGLAETESCGQTHTWPRALAVLMGLWWPRDQKAGEEDLRFRERRPGLQATATGSGEHGAFPVHSQGVWASTHWQGTAVCPLQTPPPDAFIRNNKVLS


uniprotID: Q9BX46
geneSymbol: RBM24
name: RNA-binding protein 24 (RNA-binding motif protein 24) (RNA-binding region-containing protein 6)
length: 236
go: ENSG00000112183;
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA CDS binding [GO:1990715]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell differentiation [GO:0030154]; cellular response to DNA damage stimulus [GO:0006974]; endocardial cushion development [GO:0003197]; mRNA destabilization [GO:0061157]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; negative regulation of cytoplasmic translation [GO:2000766]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myotube differentiation [GO:0010831]; positive regulation of skeletal muscle fiber differentiation [GO:1902811]; positive regulation of stem cell differentiation [GO:2000738]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA stability [GO:0043488]; regulation of myotube differentiation [GO:0010830]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BX46-1; Sequence=Displayed; Name=2; IsoId=Q9BX46-2; Sequence=VSP_022526; Name=3; IsoId=Q9BX46-5; Sequence=VSP_046775; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6GQD3}. Cytoplasm {ECO:0000250|UniProtKB:D3Z4I3}.


uniprotID: O95825
geneSymbol: CRYZL1
length: 349
go: ENSG00000205758;
snps: rs13050238
name:
Quinone oxidoreductase-like protein 1 (EC 1.-.-.-) (Protein 4P11) (Quinone oxidoreductase homolog 1) (QOH-1) (Zeta-crystallin homolog)

sequence:

opentargets:
cytosol [GO:0005829]; NADP binding [GO:0050661]; NADPH:quinone reductase activity [GO:0003960]; quinone metabolic process [GO:1901661]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95825-1; Sequence=Displayed; Name=2; IsoId=O95825-2; Sequence=VSP_055792, VSP_055793; Note=No experimental confirmation available.; 


uniprotID: P43487
geneSymbol: RANBP1
reactome: R-HSA-165054;
pdb: 1K5D;1K5G;
name: Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1)
length: 201
go: ENSG00000099901;
snps: rs5746863
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; GDP-dissociation inhibitor activity [GO:0005092]; GTPase activator activity [GO:0005096]; Ran GTPase binding [GO:0008536]; intracellular transport [GO:0046907]; signal transduction [GO:0007165]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P43487-1; Sequence=Displayed; Name=2; IsoId=P43487-2; Sequence=VSP_055104; 


uniprotID: Q8NFJ5
geneSymbol: GPRC5A
length: 357
go: ENSG00000013588;
drug: DB00755;
snps: rs11550683 rs850932 rs12368599
name:
Retinoic acid-induced protein 3 (G-protein coupled receptor family C group 5 member A) (Phorbol ester induced gene 1) (PEIG-1) (Retinoic acid-induced gene 1 protein) (RAIG-1)

sequence:

opentargets:
cytoplasmic vesicle membrane [GO:0030659]; extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; G protein-coupled receptor activity [GO:0004930]; protein kinase activator activity [GO:0030295]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9857033}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in perinuclear vesicles, probably Golgi-associated vesicles. {ECO:0000269|PubMed:18000218}.


uniprotID: Q9BQ04
geneSymbol: RBM4B
pdb: 2DGT;
length: 359
go: ENSG00000173914;
location: SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus.
name:
RNA-binding protein 4B (RNA-binding motif protein 30) (RNA-binding motif protein 4B) (RNA-binding protein 30)

sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; entrainment of circadian clock by photoperiod [GO:0043153]; mRNA cis splicing, via spliceosome [GO:0045292]; positive regulation of gene expression [GO:0010628]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of translation [GO:0006417]


uniprotID: Q9NS23
geneSymbol: RASSF1
pdb: 2KZU;
name: Ras association domain-containing protein 1
length: 344
go: ENSG00000068028;
snps: rs4688725 rs201618726 rs76335415 rs934370004 rs2073498 rs12488879 rs782655006
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle pole [GO:0000922]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein N-terminus binding [GO:0047485]; zinc ion binding [GO:0008270]; cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of cell cycle arrest [GO:0071157]; positive regulation of protein ubiquitination [GO:0031398]; protein stabilization [GO:0050821]; Ras protein signal transduction [GO:0007265]; regulation of microtubule cytoskeleton organization [GO:0070507]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=8;  Name=D {ECO:0000269|PubMed:11333291}; Synonyms=RASSF1D, Cardiac-specific {ECO:0000269|PubMed:11333291}; IsoId=Q9NS23-1; Sequence=Displayed; Note=Produced by alternative promoter usage.; Name=A {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291}; Synonyms=RASSF1A; IsoId=Q9NS23-2; Sequence=VSP_050771; Note=Produced by alternative splicing of isoform D.; Name=B {ECO:0000269|PubMed:10888881}; Synonyms=RASSF1B; IsoId=Q9NS23-3; Sequence=VSP_050770; Note=Produced by alternative splicing of isoform D.; Name=C {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291}; Synonyms=RASSF1C; IsoId=Q9NS23-4; Sequence=VSP_050773, VSP_050774; Note=Produced by alternative promoter usage.; Name=E {ECO:0000269|PubMed:11333291}; Synonyms=RASSF1E, Pancreas-specific {ECO:0000269|PubMed:11333291}; IsoId=Q9NS23-5; Sequence=VSP_050771, VSP_050772; Note=Produced by alternative splicing of isoform D.; Name=F {ECO:0000269|PubMed:11333291}; Synonyms=RASSF1F; IsoId=Q9NS23-6; Sequence=VSP_050776, VSP_050777; Note=Produced by alternative splicing of isoform D.; Name=G {ECO:0000269|PubMed:11333291}; Synonyms=RASSF1G; IsoId=Q9NS23-7; Sequence=VSP_050775, VSP_050778; Note=Produced by alternative splicing of isoform D.; Name=H; IsoId=Q9NS23-9; Sequence=VSP_050773, VSP_050774, VSP_050778; Note=Produced by alternative splicing of isoform C.; 

location:
SUBCELLULAR LOCATION: Isoform A: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; SUBCELLULAR LOCATION: Isoform C: Nucleus. Note=Predominantly nuclear.


uniprotID: P43351
geneSymbol: RAD52
reactome: R-HSA-3108214;R-HSA-5685938;
pdb: 1H2I;1KN0;5JRB;5XRZ;5XS0;
name: DNA repair protein RAD52 homolog
length: 418
go: ENSG00000002016;
snps: rs11571421 rs4987206 rs11571463
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; single-stranded DNA binding [GO:0003697]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to oxidative stress [GO:0034599]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; DNA recombinase assembly [GO:0000730]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via single-strand annealing [GO:0045002]; mitotic recombination [GO:0006312]; protein homooligomerization [GO:0051260]; regulation of nucleotide-excision repair [GO:2000819]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=alpha; IsoId=P43351-1; Sequence=Displayed; Name=beta; IsoId=P43351-2; Sequence=VSP_047753, VSP_047754; Note=Unable to interact with isoform alpha, may act as dominant negative.; Name=gamma; IsoId=P43351-3; Sequence=VSP_047750, VSP_047752; Note=Unable to interact with isoform alpha, may act as dominant negative.; Name=delta; IsoId=P43351-4; Sequence=VSP_047749, VSP_047751; Note=Unable to interact with isoform alpha, may act as dominant negative.; 


uniprotID: O00194
geneSymbol: RAB27B
reactome: R-HSA-114608;R-HSA-8873719;R-HSA-8876198;
pdb: 2F7S;
name: Ras-related protein Rab-27B (C25KG)
length: 218
go: ENSG00000041353;
snps: rs9966265
location: SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
sequence:

opentargets:
anchored component of synaptic vesicle membrane [GO:0098993]; apical plasma membrane [GO:0016324]; axon cytoplasm [GO:1904115]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; melanosome [GO:0042470]; multivesicular body membrane [GO:0032585]; plasma membrane [GO:0005886]; platelet dense granule membrane [GO:0031088]; secretory granule [GO:0030141]; trans-Golgi network transport vesicle [GO:0030140]; zymogen granule membrane [GO:0042589]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; myosin V binding [GO:0031489]; protein domain specific binding [GO:0019904]; anterograde axonal protein transport [GO:0099641]; intracellular protein transport [GO:0006886]; melanosome transport [GO:0032402]; multivesicular body sorting pathway [GO:0071985]; platelet degranulation [GO:0002576]; positive regulation of exocytosis [GO:0045921]; Rab protein signal transduction [GO:0032482]; synaptic vesicle endocytosis [GO:0048488]


uniprotID: Q14088
geneSymbol: RAB33A
reactome: R-HSA-8854214;R-HSA-8873719;
name: Ras-related protein Rab-33A (Small GTP-binding protein S10)
length: 237
go: ENSG00000134594;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; antigen processing and presentation [GO:0019882]; ER to Golgi vesicle-mediated transport [GO:0006888]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]


uniprotID: P61018
geneSymbol: RAB4B
reactome: R-HSA-6798695;R-HSA-8873719;R-HSA-8875656;
pdb: 2O52;
name: Ras-related protein Rab-4B
length: 213
go: ENSG00000167578;
sequence:

opentargets:
endosome [GO:0005768]; insulin-responsive compartment [GO:0032593]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; glucose import [GO:0046323]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61018-1; Sequence=Displayed; Name=2; IsoId=P61018-2; Sequence=VSP_013567; Note=No experimental confirmation available.; 


uniprotID: Q8N3Y7
geneSymbol: SDR16C5
reactome: R-HSA-5365859;
length: 309
go: ENSG00000170786;
snps: rs4151643
name:
Epidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; lipid droplet [GO:0005811]; nucleus [GO:0005634]; transcriptional repressor complex [GO:0017053]; activating transcription factor binding [GO:0033613]; DNA-binding transcription factor activity [GO:0003700]; retinol dehydrogenase activity [GO:0004745]; transcription factor binding [GO:0008134]; keratinocyte proliferation [GO:0043616]; negative regulation of histone acetylation [GO:0035067]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of histone deacetylation [GO:0031065]; retinal metabolic process [GO:0042574]; retinol metabolic process [GO:0042572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N3Y7-1; Sequence=Displayed; Name=2; IsoId=Q8N3Y7-2; Sequence=VSP_028389; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q96JH8
geneSymbol: RADIL
pdb: 1UM1;3EC8;
name: Ras-associating and dilute domain-containing protein
length: 1075
go: ENSG00000157927;
snps: rs3763384 rs2292498 rs414035 rs6966329
sequence:

opentargets:
microtubule [GO:0005874]; protein-containing complex [GO:0032991]; multicellular organism development [GO:0007275]; signal transduction [GO:0007165]; substrate adhesion-dependent cell spreading [GO:0034446]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=4; IsoId=Q96JH8-4; Sequence=Displayed; Name=2; IsoId=Q96JH8-2; Sequence=VSP_016098; Note=No experimental confirmation available.; Name=3; IsoId=Q96JH8-3; Sequence=VSP_016097, VSP_016099; Note=No experimental confirmation available.; Name=1; IsoId=Q96JH8-1; Sequence=VSP_035179; 


uniprotID: P51148
geneSymbol: RAB5C
reactome: R-HSA-432722;R-HSA-6798695;R-HSA-8854214;R-HSA-8856828;R-HSA-8873719;R-HSA-8876198;
pdb: 4KYI;
name: Ras-related protein Rab-5C (L1880) (RAB5L)
length: 216
go: ENSG00000108774;
sequence:

opentargets:
azurophil granule membrane [GO:0035577]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lipid droplet [GO:0005811]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; plasma membrane [GO:0005886]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; neutrophil degranulation [GO:0043312]; plasma membrane to endosome transport [GO:0048227]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P51148-1; Sequence=Displayed; Name=2; IsoId=P51148-2; Sequence=VSP_046035; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.


uniprotID: Q02833
geneSymbol: RASSF7
name: Ras association domain-containing protein 7 (HRAS1-related cluster protein 1)
length: 373
go: ENSG00000099849;
snps: rs2242183 rs2242182
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; apoptotic process [GO:0006915]; regulation of microtubule cytoskeleton organization [GO:0070507]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q02833-1; Sequence=Displayed; Name=2; IsoId=Q02833-2; Sequence=VSP_004136, VSP_004137; Name=3; IsoId=Q02833-3; Sequence=VSP_045623; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20629633}. Note=Colocalizes with gamma-tubulin.


uniprotID: P98175
geneSymbol: RBM10
pdb: 2LXI;2M2B;2MXV;2MXW;
length: 930
go: ENSG00000182872;
name:
RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA processing [GO:0006397]; negative regulation of cell proliferation [GO:0008285]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of smooth muscle cell apoptotic process [GO:0034393]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P98175-1; Sequence=Displayed; Name=2; IsoId=P98175-2; Sequence=VSP_036035; Name=3; IsoId=P98175-3; Sequence=VSP_036173; Name=4; IsoId=P98175-4; Sequence=VSP_036173, VSP_036035; Name=5; IsoId=P98175-5; Sequence=VSP_059341; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18315527}. Note=In the extranucleolar nucleoplasm constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner. Upon globally reducing RNA polymerase II transcription, the nuclear bodies enlarge and decrease in number. They occur closely adjacent to nuclear speckles or IGCs (interchromatin granule clusters) but coincide with TIDRs (transcription-inactivation-dependent RNA domains).


uniprotID: Q9P1G2
geneSymbol: RBM12B-AS1
length: 102
name:
Putative uncharacterized protein encoded by RBM12B-AS1 (RBM12B antisense RNA 1) (RBM12B antisense gene protein 1)

sequence:
MAQDFSQHPQTGIIRRHRFYSPKPLSTTPRGQSFLLSRQAKVATWDPMLSPDFQPKSAFKLTWTAQPPCLSVTPSQGQTFHPNSPEGELPPDLTENTCPSQA


uniprotID: Q92698
geneSymbol: RAD54L
name: DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (RAD54 homolog) (hHR54) (hRAD54)
length: 747
go: ENSG00000085999;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8805304}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; annealing helicase activity [GO:0036310]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; determination of adult lifespan [GO:0008340]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; meiotic cell cycle [GO:0051321]; response to drug [GO:0042493]; response to ionizing radiation [GO:0010212]

snps:
rs28363192 rs121908688 rs28363209 rs2295466 rs28363218 rs121908690 rs28363234 rs121908689 rs28363240 rs28363243 


uniprotID: Q9NS91
geneSymbol: RAD18
reactome: R-HSA-110314;R-HSA-8866654;
pdb: 2MRE;2MRF;2Y43;2YBF;5VF0;
length: 495
go: ENSG00000070950;
snps: rs45520133 rs373572 rs45569933
name:
E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18)

sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear inclusion body [GO:0042405]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Rad6-Rad18 complex [GO:0097505]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; damaged DNA binding [GO:0003684]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein-containing complex binding [GO:0044877]; single-stranded DNA-dependent ATPase activity [GO:0043142]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; Y-form DNA binding [GO:0000403]; cellular response to DNA damage stimulus [GO:0006974]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; negative regulation of cell death [GO:0060548]; positive regulation of chromosome segregation [GO:0051984]; postreplication repair [GO:0006301]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; response to UV [GO:0009411]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15632077}. Note=Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}.


uniprotID: Q9NP72
geneSymbol: RAB18
reactome: R-HSA-6798695;R-HSA-6811436;R-HSA-8873719;R-HSA-8876198;
pdb: 1X3S;
name: Ras-related protein Rab-18
length: 206
go: ENSG00000099246;
snps: rs387906832 rs12268932 rs11015859
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; Golgi apparatus [GO:0005794]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; synapse [GO:0045202]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; brain development [GO:0007420]; endoplasmic reticulum tubular network organization [GO:0071786]; eye development [GO:0001654]; import into nucleus [GO:0051170]; intracellular protein transport [GO:0006886]; lipid droplet organization [GO:0034389]; neutrophil degranulation [GO:0043312]; Rab protein signal transduction [GO:0032482]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NP72-1; Sequence=Displayed; Name=2; IsoId=Q9NP72-2; Sequence=VSP_043912; Note=Highly expressed in testis.; Name=3; IsoId=Q9NP72-3; Sequence=VSP_044883; Note=No experimental confirmation available.; 


uniprotID: Q9UJ41
geneSymbol: RABGEF1
reactome: R-HSA-8854214;R-HSA-8876198;
pdb: 1TXU;2C7M;2C7N;2OT3;4N3X;4N3Y;4N3Z;4Q9U;
name: Rab5 GDP/GTP exchange factor (RAP1) (Rabaptin-5-associated exchange factor for Rab5) (Rabex-5)
length: 708
go: ENSG00000154710;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; DNA binding [GO:0003677]; Rab GTPase binding [GO:0017137]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; zinc ion binding [GO:0008270]; endocytosis [GO:0006897]; protein targeting to membrane [GO:0006612]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UJ41-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9UJ41-2; Sequence=VSP_010690, VSP_010691, VSP_010692; Name=3; Synonyms=Long; IsoId=Q9UJ41-3; Sequence=VSP_010690, VSP_010692; Name=4; IsoId=Q9UJ41-4; Sequence=VSP_054643, VSP_054644, VSP_010691, VSP_010692; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12505986}. Early endosome {ECO:0000269|PubMed:12505986}. Recycling endosome {ECO:0000269|PubMed:12505986}.


uniprotID: Q9UBK7
geneSymbol: RABL2A
name: Rab-like protein 2A
length: 228
go: ENSG00000144134;
sequence:

opentargets:
intracellular [GO:0005622]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UBK7-1; Sequence=Displayed; Name=2; IsoId=Q9UBK7-2; Sequence=VSP_005531; Note=No experimental confirmation available.; Name=3; IsoId=Q9UBK7-3; Sequence=VSP_041060; 


uniprotID: Q96H35
geneSymbol: RBM18
name: Probable RNA-binding protein 18 (RNA-binding motif protein 18)
length: 190
go: ENSG00000119446;
opentargets: RNA binding [GO:0003723]
sequence:
MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKLLQKFGKVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPTQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPDKKRTTPYSRTAWKSRR


uniprotID: O15541
geneSymbol: RNF113A
pdb: 5Z56;5Z58;6FF4;
length: 343
go: ENSG00000125352;
name:
E3 ubiquitin-protein ligase RNF113A (EC 2.3.2.27) (Cwc24 homolog) (RING finger protein 113A) (Zinc finger protein 183)

sequence:

opentargets:
nuclear speck [GO:0016607]; U2-type spliceosomal complex [GO:0005684]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; DNA repair [GO:0006281]; isopeptide cross-linking via N6-glycyl-L-lysine [GO:0018276]; mRNA processing [GO:0006397]; negative regulation of chemokine-mediated signaling pathway [GO:0070100]; protein ubiquitination [GO:0016567]; snoRNA splicing [GO:0034247]

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:29144457}. Note=Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles. {ECO:0000269|PubMed:29144457}.


uniprotID: Q7Z6E9
geneSymbol: RBBP6
reactome: R-HSA-983168;
pdb: 2C7H;2YSA;2YUR;3ZTG;
length: 1792
go: ENSG00000122257;
snps: rs16973796 rs16973840 rs3743968
name:
E3 ubiquitin-protein ligase RBBP6 (EC 2.3.2.27) (Proliferation potential-related protein) (Protein P2P-R) (RING-type E3 ubiquitin transferase RBBP6) (Retinoblastoma-binding Q protein 1) (RBQ-1) (Retinoblastoma-binding protein 6) (p53-associated cellular protein of testis)

sequence:

opentargets:
chromosome [GO:0005694]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; protein-containing complex [GO:0032991]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cellular response to DNA damage stimulus [GO:0006974]; DNA replication [GO:0006260]; embryonic organ development [GO:0048568]; in utero embryonic development [GO:0001701]; mRNA processing [GO:0006397]; multicellular organism growth [GO:0035264]; protein polyubiquitination [GO:0000209]; regulation of DNA replication [GO:0006275]; somite development [GO:0061053]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q7Z6E9-1; Sequence=Displayed; Name=2; IsoId=Q7Z6E9-2; Sequence=VSP_018284; Name=3; IsoId=Q7Z6E9-3; Sequence=VSP_018281, VSP_018282; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z6E9-4; Sequence=VSP_018283; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with mitotic chromosomes. Colocalizes with NEK6 in the centrosome.


uniprotID: P28749
geneSymbol: RBL1
reactome: R-HSA-1362277;R-HSA-1362300;R-HSA-1538133;R-HSA-2173796;R-HSA-539107;R-HSA-6804114;R-HSA-69231;
pdb: 1H28;4YOO;4YOS;4YOZ;5TUV;
name: Retinoblastoma-like protein 1 (107 kDa retinoblastoma-associated protein) (p107) (pRb1)
length: 1068
go: ENSG00000080839;
snps: rs8114297
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
chromatin [GO:0000785]; nucleoplasm [GO:0005654]; transcription factor complex [GO:0005667]; promoter-specific chromatin binding [GO:1990841]; RNA polymerase II activating transcription factor binding [GO:0001102]; RNA polymerase II regulatory region DNA binding [GO:0001012]; transcription factor binding [GO:0008134]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; chromatin organization [GO:0006325]; negative regulation of cellular senescence [GO:2000773]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell division [GO:0051302]; regulation of lipid kinase activity [GO:0043550]; regulation of mitotic cell cycle [GO:0007346]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P28749-1; Sequence=Displayed; Name=2; IsoId=P28749-2; Sequence=VSP_017496; 


uniprotID: P20936
geneSymbol: RASA1
reactome: R-HSA-186763;R-HSA-3928662;R-HSA-5218921;R-HSA-5658442;R-HSA-6802949;R-HSA-8849471;
pdb: 1WER;1WQ1;2GQI;2GSB;2J05;2J06;2M51;4FSS;
length: 1047
go: ENSG00000145715;
snps: rs137853214 rs137853215 rs137853216 rs145752649 rs137853217 rs373098580
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8360177}.
name:
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; phosphotyrosine residue binding [GO:0001784]; potassium channel inhibitor activity [GO:0019870]; signaling receptor binding [GO:0005102]; blood vessel morphogenesis [GO:0048514]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; mitotic cytokinesis [GO:0000281]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of Ras protein signal transduction [GO:0046580]; regulation of actin filament polymerization [GO:0030833]; regulation of cell shape [GO:0008360]; regulation of RNA metabolic process [GO:0051252]; signal transduction [GO:0007165]; vasculogenesis [GO:0001570]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Long; IsoId=P20936-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P20936-2; Sequence=VSP_001625, VSP_001626; Name=3; IsoId=P20936-3; Sequence=VSP_057434, VSP_057435; Note=No experimental confirmation available.; Name=4; IsoId=P20936-4; Sequence=VSP_057432, VSP_057433; Note=No experimental confirmation available.; 


uniprotID: O75452
geneSymbol: RDH16
reactome: R-HSA-2453902;R-HSA-5365859;
length: 317
go: ENSG00000139547;
name:
Retinol dehydrogenase 16 (EC 1.1.-.-) (Microsomal NAD(+)-dependent retinol dehydrogenase 4) (RoDH-4) (Short chain dehydrogenase/reductase family 9C member 8) (Sterol/retinol dehydrogenase)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; electron transfer activity [GO:0009055]; retinol dehydrogenase activity [GO:0004745]; lipid metabolic process [GO:0006629]

location:
SUBCELLULAR LOCATION: Microsome membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.


uniprotID: Q9HBD1
geneSymbol: RC3H2
pdb: 4Z30;4Z31;4ZLC;4ZLD;
length: 1191
go: ENSG00000056586;
name:
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)

sequence:

opentargets:
cell surface [GO:0009986]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; P-body [GO:0000932]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded RNA binding [GO:0003725]; metal ion binding [GO:0046872]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin-protein transferase activity [GO:0004842]; B cell homeostasis [GO:0001782]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lymph node development [GO:0048535]; multicellular organism growth [GO:0035264]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; post-embryonic development [GO:0009791]; posttranscriptional regulation of gene expression [GO:0010608]; protein polyubiquitination [GO:0000209]; regulation of miRNA metabolic process [GO:2000628]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q9HBD1-1; Sequence=Displayed; Name=2; IsoId=Q9HBD1-2; Sequence=VSP_015021, VSP_015022; Note=No experimental confirmation available.; Name=3; IsoId=Q9HBD1-3; Sequence=VSP_015020, VSP_015023; Note=No experimental confirmation available.; Name=4; IsoId=Q9HBD1-4; Sequence=VSP_015024; Name=5; IsoId=Q9HBD1-5; Sequence=VSP_015018, VSP_015019; Note=No experimental confirmation available.; Name=6; IsoId=Q9HBD1-6; Sequence=VSP_015017, VSP_015024; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250}. Note=During stress, such as that induced by arsenite, localizes to cytosolic stress granules. Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger. {ECO:0000269|PubMed:20412057}.


uniprotID: P48382
geneSymbol: RFX5
pdb: 2KW3;3V30;
name: DNA-binding protein RFX5 (Regulatory factor X 5)
length: 616
go: ENSG00000143390;
snps: rs137853099 rs2233851 rs2233854 rs2233855
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48382-1; Sequence=Displayed; Name=2; IsoId=P48382-2; Sequence=VSP_055864; Note=No experimental confirmation available.; 


uniprotID: O14827
geneSymbol: RASGRF2
reactome: R-HSA-193648;R-HSA-194840;R-HSA-416482;R-HSA-442982;R-HSA-5673001;
length: 1237
go: ENSG00000113319;
snps: rs779986744 rs1466151520 rs16878472
name:
Ras-specific guanine nucleotide-releasing factor 2 (Ras-GRF2) (Ras guanine nucleotide exchange factor 2)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; G protein-coupled receptor signaling pathway [GO:0007186]; MAPK cascade [GO:0000165]; positive regulation of apoptotic process [GO:0043065]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to endoplasmic reticulum stress [GO:0034976]; small GTPase mediated signal transduction [GO:0007264]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.


uniprotID: Q9UNA1
geneSymbol: ARHGAP26
reactome: R-HSA-194840;
pdb: 1UGV;
length: 814
go: ENSG00000145819;
snps: rs121918546
name:
Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)

sequence:

opentargets:
cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; GTPase activator activity [GO:0005096]; phospholipid binding [GO:0005543]; actin cytoskeleton organization [GO:0030036]; nervous system development [GO:0007399]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UNA1-1; Sequence=Displayed; Name=2; IsoId=Q9UNA1-2; Sequence=VSP_001659; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.


uniprotID: O43182
geneSymbol: ARHGAP6
reactome: R-HSA-194840;
length: 974
go: ENSG00000047648;
snps: rs1009758
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10699171}.
name:
Rho GTPase-activating protein 6 (Rho-type GTPase-activating protein 6) (Rho-type GTPase-activating protein RhoGAPX-1)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; phospholipase activator activity [GO:0016004]; phospholipase binding [GO:0043274]; SH3 domain binding [GO:0017124]; SH3/SH2 adaptor activity [GO:0005070]; actin filament polymerization [GO:0030041]; activation of phospholipase C activity [GO:0007202]; focal adhesion assembly [GO:0048041]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of phospholipase activity [GO:0010518]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=3; IsoId=O43182-1; Sequence=Displayed; Name=1; IsoId=O43182-2; Sequence=VSP_001641, VSP_001642; Name=2; IsoId=O43182-3; Sequence=VSP_001638, VSP_001639, VSP_001640; Name=4; IsoId=O43182-4; Sequence=VSP_001637; Name=5; IsoId=O43182-5; Sequence=VSP_001637, VSP_001641, VSP_001642; 


uniprotID: O14559
geneSymbol: ARHGAP33
reactome: R-HSA-194840;
length: 1287
go: ENSG00000004777;
name:
Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091]; protein kinase binding [GO:0019901]; protein transport [GO:0015031]; regulation of dendritic spine morphogenesis [GO:0061001]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to toxic substance [GO:0009636]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O14559-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=O14559-10; Sequence=VSP_014287, VSP_014292; Name=3; IsoId=O14559-11; Sequence=VSP_014291; Name=4; IsoId=O14559-12; Sequence=VSP_014288, VSP_014289, VSP_014290; 


uniprotID: Q15669
geneSymbol: RHOH
reactome: R-HSA-194840;
name: Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
length: 191
go: ENSG00000168421;
sequence:
MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGIQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANHNSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQREMGPHRASCVNAMEGKKLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRLFSINECKIF

opentargets:
cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; immunological synapse [GO:0001772]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase inhibitor activity [GO:0005095]; kinase inhibitor activity [GO:0019210]; protein kinase binding [GO:0019901]; Rho GTPase binding [GO:0017048]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; establishment or maintenance of cell polarity [GO:0007163]; mast cell activation [GO:0045576]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; regulation of transcription, DNA-templated [GO:0006355]; Rho protein signal transduction [GO:0007266]; T cell differentiation [GO:0030217]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.


uniprotID: Q9H4E5
geneSymbol: RHOJ
reactome: R-HSA-194840;
length: 214
go: ENSG00000126785;
name:
Rho-related GTP-binding protein RhoJ (Ras-like protein family member 7B) (Tc10-like GTP-binding protein)

sequence:

opentargets:
cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; cell projection assembly [GO:0030031]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; retina vasculature morphogenesis in camera-type eye [GO:0061299]; Rho protein signal transduction [GO:0007266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H4E5-1; Sequence=Displayed; Name=2; IsoId=Q9H4E5-2; Sequence=VSP_007231; Note=No experimental confirmation available. Could be created by usage of an unusual splicing donor site.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27660391, ECO:0000269|PubMed:30158707}; Lipid-anchor {ECO:0000269|PubMed:30158707}; Cytoplasmic side {ECO:0000305}. Note=Localization to the plasma membrane is regulated by GLUL. {ECO:0000269|PubMed:30158707}.


uniprotID: Q96L33
geneSymbol: RHOV
reactome: R-HSA-194840;
length: 236
go: ENSG00000104140;
name:
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)

sequence:

opentargets:
cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; Cdc42 protein signal transduction [GO:0032488]; cell projection assembly [GO:0030031]; endocytosis [GO:0006897]; establishment or maintenance of cell polarity [GO:0007163]; regulation of cell shape [GO:0008360]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Endosome membrane {ECO:0000250|UniProtKB:Q9Z1Y0}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z1Y0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z1Y0}. Note=Treatment with TNF activates endosomal but not plasma membrane RHOV. {ECO:0000250|UniProtKB:Q9Z1Y0}.


uniprotID: Q9ULI2
geneSymbol: RIMKLB
reactome: R-HSA-70614;
length: 386
go: ENSG00000166532;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Beta-citrylglutamate synthase B (EC 6.3.1.17) (N-acetyl-aspartylglutamate synthetase B) (NAAG synthetase B) (NAAGS) (EC 6.3.2.41) (Ribosomal protein S6 modification-like protein B)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; citrate-L-glutamate ligase activity [GO:0072591]; metal ion binding [GO:0046872]; N-acetyl-L-aspartate-L-glutamate ligase activity [GO:0072590]; cellular amino acid biosynthetic process [GO:0008652]; cellular protein modification process [GO:0006464]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULI2-1; Sequence=Displayed; Name=2; IsoId=Q9ULI2-2; Sequence=VSP_024198, VSP_024199; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q9NRR4
geneSymbol: DROSHA
reactome: R-HSA-203927;
pdb: 2KHX;2NA2;5B16;
name: Ribonuclease 3 (EC 3.1.26.3) (Protein Drosha) (Ribonuclease III) (RNase III) (p241)
length: 1374
go: ENSG00000113360;
snps: rs35342496 rs55656741
sequence:

opentargets:
microprocessor complex [GO:0070877]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; DEAD/H-box RNA helicase binding [GO:0017151]; double-stranded RNA binding [GO:0003725]; lipopolysaccharide binding [GO:0001530]; metal ion binding [GO:0046872]; primary miRNA binding [GO:0070878]; protein homodimerization activity [GO:0042803]; R-SMAD binding [GO:0070412]; ribonuclease III activity [GO:0004525]; RNA binding [GO:0003723]; SMAD binding [GO:0046332]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; miRNA metabolic process [GO:0010586]; positive regulation of gene expression [GO:0010628]; pre-miRNA processing [GO:0031054]; primary miRNA processing [GO:0031053]; production of siRNA involved in RNA interference [GO:0030422]; regulation of inflammatory response [GO:0050727]; regulation of miRNA metabolic process [GO:2000628]; regulation of regulatory T cell differentiation [GO:0045589]; ribosome biogenesis [GO:0042254]; RNA processing [GO:0006396]; rRNA catabolic process [GO:0016075]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9NRR4-1; Sequence=Displayed; Name=2; IsoId=Q9NRR4-2; Sequence=VSP_005777; Note=No experimental confirmation available.; Name=3; IsoId=Q9NRR4-3; Sequence=VSP_012450, VSP_012451, VSP_012452, VSP_012453; Note=No experimental confirmation available.; Name=4; IsoId=Q9NRR4-4; Sequence=VSP_012450, VSP_012451; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:22118463}. Nucleus, nucleolus {ECO:0000269|PubMed:10948199}. Note=A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies. {ECO:0000269|PubMed:10948199, ECO:0000269|PubMed:22118463}.


uniprotID: O43567
geneSymbol: RNF13
length: 381
go: ENSG00000082996;
name:
E3 ubiquitin-protein ligase RNF13 (EC 2.3.2.27) (RING finger protein 13) (RING-type E3 ubiquitin transferase RNF13)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; nuclear inner membrane [GO:0005637]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43567-1; Sequence=Displayed; Name=2; IsoId=O43567-2; Sequence=VSP_055430, VSP_055431; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lysosome membrane. Nucleus inner membrane {ECO:0000250}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250}.


uniprotID: Q96BH1
geneSymbol: RNF25
reactome: R-HSA-983168;
pdb: 2DAY;2DMF;5D1K;5D1L;5D1M;
length: 459
go: ENSG00000163481;
name:
E3 ubiquitin-protein ligase RNF25 (EC 2.3.2.27) (RING finger protein 25) (RING-type E3 ubiquitin transferase RNF25)

sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; NF-kappaB binding [GO:0051059]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein ubiquitination [GO:0016567]


uniprotID: Q9BY78
geneSymbol: RNF26
name: E3 ubiquitin-protein ligase RNF26 (EC 2.3.2.27) (RING finger protein 26)
length: 433
go: ENSG00000173456;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; endosome organization [GO:0007032]; negative regulation of defense response to virus [GO:0050687]; protein K11-linked ubiquitination [GO:0070979]; protein localization to perinuclear region of cytoplasm [GO:1905719]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25254379, ECO:0000269|PubMed:27368102}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: P26373
geneSymbol: RPL13
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L13 (Breast basic conserved protein 1) (Large ribosomal subunit protein eL13)
length: 211
go: ENSG00000167526;
snps: rs9930567 rs1062450
sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic ribosome [GO:0022626]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P26373-1; Sequence=Displayed; Name=2; IsoId=P26373-2; Sequence=VSP_046028; Note=No experimental confirmation available.; 


uniprotID: P84098
geneSymbol: RPL19
pdb: 4UG0;4V6X;5A2Q;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L19 (Large ribosomal subunit protein eL19)
length: 196
go: ENSG00000108298;
drug: DB02494;DB07374;DB08437;
sequence:
MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLIIRKPVTVHSRARCRKNTLARRKGRHMGIGKRKGTANARMPEKVTWMRRMRILRRLLRRYRESKKIDRHMYHSLYLKVKGNVFKNKRILMEHIHKLKADKARKKLLADQAEARRSKTKEARKRREERLQAKKEEIIKTLSKEEETKK

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; synapse [GO:0045202]; 5.8S rRNA binding [GO:1990932]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; liver regeneration [GO:0097421]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: O76021
geneSymbol: RSL1D1
length: 490
go: ENSG00000171490;
name:
Ribosomal L1 domain-containing protein 1 (CATX-11) (Cellular senescence-inhibited gene protein) (Protein PBK1)

sequence:

opentargets:
90S preribosome [GO:0030686]; membrane [GO:0016020]; nucleolus [GO:0005730]; cadherin binding [GO:0045296]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; maturation of LSU-rRNA [GO:0000470]; osteoblast differentiation [GO:0001649]; regulation of apoptotic process [GO:0042981]; regulation of cellular senescence [GO:2000772]; regulation of protein localization [GO:0032880]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O76021-1; Sequence=Displayed; Name=2; IsoId=O76021-2; Sequence=VSP_056143; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18678645, ECO:0000269|PubMed:22419112}. Note=Colocalizes with ING1 in the nucleolus after UV stress. {ECO:0000269|PubMed:22419112}.


uniprotID: Q2M1Z3
geneSymbol: ARHGAP31
reactome: R-HSA-194840;
name: Rho GTPase-activating protein 31 (Cdc42 GTPase-activating protein)
length: 1444
go: ENSG00000031081;
snps: rs751793 rs539048828 rs3732413 rs12107254 rs3796360 rs9852894
location: SUBCELLULAR LOCATION: Cell projection, lamellipodium. Cell junction, focal adhesion {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]


uniprotID: O00212
geneSymbol: RHOD
reactome: R-HSA-194840;R-HSA-5663220;
pdb: 2J1L;
name: Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1)
length: 210
snps: rs4930409
sequence:

opentargets:
cell cortex [GO:0005938]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; cell migration [GO:0016477]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; focal adhesion assembly [GO:0048041]; lamellipodium assembly [GO:0030032]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell migration [GO:0030335]; protein targeting [GO:0006605]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin cytoskeleton reorganization [GO:2000249]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; regulation of focal adhesion assembly [GO:0051893]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}.


uniprotID: Q53QZ3
geneSymbol: ARHGAP15
reactome: R-HSA-194840;
pdb: 3BYI;
name: Rho GTPase-activating protein 15 (ArhGAP15) (Rho-type GTPase-activating protein 15)
length: 475
go: ENSG00000075884;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12650940}. Membrane {ECO:0000269|PubMed:12650940}; Peripheral membrane protein {ECO:0000269|PubMed:12650940}.


uniprotID: Q5UIP0
geneSymbol: RIF1
reactome: R-HSA-5693571;
name: Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)
length: 2472
go: ENSG00000080345;
snps: rs2444263 rs2123465 rs3732305 rs2444258 rs2444257 rs16830057 rs1065177
sequence:

opentargets:
chromosome, telomeric region [GO:0000781]; condensed chromosome [GO:0000793]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nuclear body [GO:0016604]; nuclear chromatin [GO:0000790]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; site of double-strand break [GO:0035861]; spindle midzone [GO:0051233]; cell cycle [GO:0007049]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to leukemia inhibitory factor [GO:1990830]; chromatin silencing at telomere [GO:0006348]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of double-strand break repair via nonhomologous end joining [GO:2001034]; positive regulation of histone H3-K9 methylation [GO:0051574]; positive regulation of isotype switching [GO:0045830]; stem cell population maintenance [GO:0019827]; telomere maintenance [GO:0000723]; telomere maintenance in response to DNA damage [GO:0043247]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5UIP0-1; Sequence=Displayed; Name=2; IsoId=Q5UIP0-2; Sequence=VSP_014431; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15583028}. Chromosome {ECO:0000250|UniProtKB:Q6PR54}. Chromosome, telomere {ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15583028}. Note=Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (By similarity). Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs) (PubMed:15342490). Does not associate with normal telomere structures (PubMed:15342490, PubMed:15583028). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (PubMed:15583028). {ECO:0000250|UniProtKB:Q6PR54, ECO:0000269|PubMed:15342490, ECO:0000269|PubMed:15583028}.


uniprotID: A6NNM3
geneSymbol: RIMBP3B
name: RIMS-binding protein 3B (RIM-BP3.B) (RIMS-binding protein 3.2) (RIM-BP3.2)
length: 1639
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3V0F0}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; benzodiazepine receptor binding [GO:0030156]; fertilization [GO:0009566]; spermatid development [GO:0007286]


uniprotID: Q9NWU5
geneSymbol: MRPL22
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;5OOL;5OOM;
length: 206
go: ENSG00000082515;
snps: rs3749671
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
name:
39S ribosomal protein L22, mitochondrial (L22mt) (MRP-L22) (39S ribosomal protein L25, mitochondrial) (L25mt) (MRP-L25) (Mitochondrial large ribosomal subunit protein uL22m)

sequence:

opentargets:
large ribosomal subunit [GO:0015934]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; ribosome assembly [GO:0042255]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NWU5-1; Sequence=Displayed; Name=2; IsoId=Q9NWU5-2; Sequence=VSP_021745; Name=3; IsoId=Q9NWU5-3; Sequence=VSP_044501; 


uniprotID: Q99496
geneSymbol: RNF2
pdb: 2H0D;3GS2;3H8H;3IXS;3RPG;4R8P;4S3O;
length: 336
go: ENSG00000121481;
reactome:
R-HSA-2559580;R-HSA-3108214;R-HSA-3899300;R-HSA-4551638;R-HSA-4570464;R-HSA-4655427;R-HSA-8939243;R-HSA-8943724;R-HSA-8953750;

name:
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)

sequence:

opentargets:
euchromatin [GO:0000791]; MLL1 complex [GO:0071339]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; sex chromatin [GO:0001739]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; RING-like zinc finger domain binding [GO:0071535]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; anterior/posterior axis specification [GO:0009948]; gastrulation with mouth forming second [GO:0001702]; germ cell development [GO:0007281]; histone H2A monoubiquitination [GO:0035518]; histone H2A-K119 monoubiquitination [GO:0036353]; mitotic cell cycle [GO:0000278]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of transcription by RNA polymerase II [GO:0000122]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99496-1; Sequence=Displayed; Name=2; IsoId=Q99496-2; Sequence=VSP_055439; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Chromosome {ECO:0000250|UniProtKB:Q9CQJ4}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. {ECO:0000250|UniProtKB:Q9CQJ4}.


uniprotID: Q9UJD0
geneSymbol: RIMS3
length: 308
go: ENSG00000117016;
location: SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250}.
name:
Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3)

sequence:

opentargets:
cell junction [GO:0030054]; cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; ion channel binding [GO:0044325]; Rab GTPase binding [GO:0017137]; calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UJD0-1; Sequence=Displayed; Name=2; IsoId=Q9UJD0-2; Sequence=VSP_055836, VSP_055837; 


uniprotID: Q9H426
geneSymbol: RIMS4
length: 269
go: ENSG00000101098;
location: SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250}.
name:
Regulating synaptic membrane exocytosis protein 4 (RIM4 gamma) (Rab3-interacting molecule 4) (RIM 4)

sequence:

opentargets:
cell junction [GO:0030054]; cytoskeleton of presynaptic active zone [GO:0048788]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic membrane [GO:0097060]; ion channel binding [GO:0044325]; Rab GTPase binding [GO:0017137]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; positive regulation of synaptic transmission [GO:0050806]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H426-1; Sequence=Displayed; Name=2; IsoId=Q9H426-2; Sequence=VSP_044881; Note=No experimental confirmation available.; 


uniprotID: Q9P0M9
geneSymbol: MRPL27
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 148
go: ENSG00000108826;
snps: rs17776919
name:
39S ribosomal protein L27, mitochondrial (L27mt) (MRP-L27) (Mitochondrial large ribosomal subunit protein bL27m)

sequence:
MASVVLALRTRTAVTSLLSPTPATALAVRYASKKSGGSSKNLGGKSSGRRQGIKKMEGHYVHAGNIIATQRHFRWHPGAHVGVGKNKCLYALEEGIVRYTKEVYVPHPRNTEAVDLITRLPKGAVLYKTFVHVVPAKPEGTFKLVAML

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: Q6NUQ1
geneSymbol: RINT1
reactome: R-HSA-6811434;
name: RAD50-interacting protein 1 (RAD50 interactor 1) (HsRINT-1) (RINT-1)
length: 792
go: ENSG00000135249;
snps: rs11556986 rs35971380 rs34310648
location: SUBCELLULAR LOCATION: Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
sequence:

opentargets:
cytosol [GO:0005829]; Dsl1/NZR complex [GO:0070939]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; cell cycle [GO:0007049]; Golgi organization [GO:0007030]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; regulation of signal transduction involved in mitotic G2 DNA damage checkpoint [GO:1902504]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]


uniprotID: Q9BRS2
geneSymbol: RIOK1
reactome: R-HSA-6791226;
pdb: 4OTP;6G5I;
name: Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)
length: 568
go: ENSG00000124784;
snps: rs56067778
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21081503}.
sequence:

opentargets:
cytosol [GO:0005829]; methyltransferase complex [GO:0034708]; nucleoplasm [GO:0005654]; preribosome, small subunit precursor [GO:0030688]; ATP binding [GO:0005524]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; maturation of SSU-rRNA [GO:0030490]; positive regulation of rRNA processing [GO:2000234]; ribosomal small subunit biogenesis [GO:0042274]


uniprotID: O75394
geneSymbol: MRPL33
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
sequence: MFLSAVFFAKSKSKNILVRMVSEAGTGFCFNTKRNRLREKLTLLHYDPVVKQRVLFVEKKKIRSL
length: 65
go: ENSG00000243147;
name:
39S ribosomal protein L33, mitochondrial (L33mt) (MRP-L33) (Mitochondrial large ribosomal subunit protein bL33m)

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75394-1; Sequence=Displayed; Name=2; IsoId=O75394-2; Sequence=VSP_042822; Note=No experimental confirmation available.; 


uniprotID: Q9BQ48
geneSymbol: MRPL34
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
sequence: MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQARGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH
length: 92
go: ENSG00000130312;
name:
39S ribosomal protein L34, mitochondrial (L34mt) (MRP-L34) (Mitochondrial large ribosomal subunit protein bL34m)

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q9H6W3
geneSymbol: RIOX1
pdb: 4CCJ;4CCK;4CCM;4CCN;4CCO;4DIQ;4E4H;4Y33;4Y3O;4Y4R;
length: 641
go: ENSG00000170468;
snps: rs10144469 rs758109 rs34970526 rs3813563
name:
Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; histone demethylase activity (H3-K36 specific) [GO:0051864]; histone demethylase activity (H3-K4 specific) [GO:0032453]; iron ion binding [GO:0005506]; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [GO:0016706]; histone H3-K36 demethylation [GO:0070544]; histone H3-K4 demethylation [GO:0034720]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H6W3-1; Sequence=Displayed; Name=2; IsoId=Q9H6W3-2; Sequence=VSP_038663; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.


uniprotID: Q8IUF8
geneSymbol: RIOX2
reactome: R-HSA-3214842;
pdb: 2XDV;4BU2;4BXF;
length: 465
go: ENSG00000170854;
snps: rs35391656 rs56183666 rs2172257
name:
Ribosomal oxygenase 2 (60S ribosomal protein L27a histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA) (EC 1.14.11.-) (Histone lysine demethylase MINA) (MYC-induced nuclear antigen) (Mineral dust-induced gene protein) (Nucleolar protein 52) (Ribosomal oxygenase MINA) (ROX)

sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; dioxygenase activity [GO:0051213]; histone demethylase activity [GO:0032452]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; ribosome biogenesis [GO:0042254]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:14742713, ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15897898, ECO:0000269|Ref.4}; IsoId=Q8IUF8-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12091391}; IsoId=Q8IUF8-2; Sequence=VSP_052589, VSP_052590; Name=3 {ECO:0000269|PubMed:15897898}; IsoId=Q8IUF8-3; Sequence=VSP_052587, VSP_052588; Name=4; IsoId=Q8IUF8-4; Sequence=VSP_038373; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}. Nucleus, nucleolus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}.


uniprotID: Q9BZE1
geneSymbol: MRPL37
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 423
go: ENSG00000116221;
snps: rs2275408 rs13571
name:
39S ribosomal protein L37, mitochondrial (L37mt) (MRP-L37) (39S ribosomal protein L2, mitochondrial) (L2mt) (MRP-L2) (Mitochondrial large ribosomal subunit protein mL37)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q9BRJ2
geneSymbol: MRPL45
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 306
snps: rs34749623
name:
39S ribosomal protein L45, mitochondrial (L45mt) (MRP-L45) (Mitochondrial large ribosomal subunit protein mL45)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q9H2W6
geneSymbol: MRPL46
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 279
snps: rs16941888
name:
39S ribosomal protein L46, mitochondrial (L46mt) (MRP-L46) (Mitochondrial large ribosomal subunit protein mL46) (P2ECSL)

sequence:

opentargets:
cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; hydrolase activity [GO:0016787]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q9HD33
geneSymbol: MRPL47
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 250
go: ENSG00000136522;
snps: rs2339844 rs10513762
name:
39S ribosomal protein L47, mitochondrial (L47mt) (MRP-L47) (Mitochondrial large ribosomal subunit protein uL29m) (Nasopharyngeal carcinoma metastasis-related protein 1)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9HD33-1; Sequence=Displayed; Name=2; IsoId=Q9HD33-2; Sequence=VSP_035650; Name=3; IsoId=Q9HD33-3; Sequence=VSP_035649; 


uniprotID: Q96GC5
geneSymbol: MRPL48
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 212
go: ENSG00000175581;
snps: rs17850551
name:
39S ribosomal protein L48, mitochondrial (L48mt) (MRP-L48) (Mitochondrial large ribosomal subunit protein mL48)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GC5-1; Sequence=Displayed; Name=2; IsoId=Q96GC5-3; Sequence=VSP_054130; Note=No experimental confirmation available.; 


uniprotID: Q13405
geneSymbol: MRPL49
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 166
go: ENSG00000149792;
snps: rs17146691
name:
39S ribosomal protein L49, mitochondrial (L49mt) (MRP-L49) (Mitochondrial large ribosomal subunit protein mL49) (Neighbor of FAU) (NOF) (Protein NOF1)

sequence:
MAATMFRATLRGWRTGVQRGCGLRLLSQTQGPPDYPRFVESVDEYQFVERLLPATRIPDPPKHEHYPTPSGWQPPRDPPPNLPYFVRRSRMHNIPVYKDITHGNRQMTVIRKVEGDIWALQKDVEDFLSPLLGKTPVTQVNEVTGTLRIKGYFDQELKAWLLEKGF

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q8N5N7
geneSymbol: MRPL50
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 158
go: ENSG00000136897;
snps: rs8131
name:
39S ribosomal protein L50, mitochondrial (L50mt) (MRP-L50) (Mitochondrial large ribosomal subunit protein mL50)

sequence:
MAARSVSGITRRVFMWTVSGTPCREFWSRFRKEKEPVVVETVEEKKEPILVCPPLRSRAYTPPEDLQSRLESYVKEVFGSSLPSNWQDISLEDSRLKFNLLAHLADDLGHVVPNSRLHQMCRVRDVLDFYNVPIQDRSKFDELSASNLPPNLKITWSY

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N5N7-1; Sequence=Displayed; Name=2; IsoId=Q8N5N7-2; Sequence=VSP_056091; Note=No experimental confirmation available.; 


uniprotID: Q4U2R6
geneSymbol: MRPL51
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 128
go: ENSG00000111639;
snps: rs9526
name:
39S ribosomal protein L51, mitochondrial (L51mt) (MRP-L51) (Mitochondrial large ribosomal subunit protein mL51) (bMRP-64) (bMRP64)

sequence:
MAGNLLSGAGRRLWDWVPLACRSFSLGVPRLIGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLRGWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q86TS9
geneSymbol: MRPL52
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;5OOL;5OOM;
length: 123
go: ENSG00000172590;
snps: rs1135641 rs4982685 rs11538931
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
name:
39S ribosomal protein L52, mitochondrial (L52mt) (MRP-L52) (Mitochondrial large ribosomal subunit protein mL52)

sequence:
MAALGTVLFTGVRRLHCSVAAWAGGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERETFARRVVLLSQEMDAGLQAWQLRQQKLQEEQRKQENALKPKGASLKSPLPSQ

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86TS9-1; Sequence=Displayed; Name=2; IsoId=Q86TS9-2; Sequence=VSP_044560; Note=No experimental confirmation available.; Name=3; IsoId=Q86TS9-3; Sequence=VSP_045242; Name=4; IsoId=Q86TS9-4; Sequence=VSP_054094, VSP_054095; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q86UA6
geneSymbol: RPAIN
name: RPA-interacting protein (hRIP)
length: 219
go: ENSG00000129197;
snps: rs12761
sequence:

opentargets:
cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; PML body [GO:0016605]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA-dependent DNA replication [GO:0006261]; protein import into nucleus [GO:0006606]; response to UV [GO:0009411]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Name=1; Synonyms=Alpha, hRIPalpha; IsoId=Q86UA6-1; Sequence=Displayed; Note=Major isoform with isoform 2.; Name=2; Synonyms=Beta, hRIPbeta; IsoId=Q86UA6-2; Sequence=VSP_016410; Note=Major isoform with isoform 1.; Name=3; Synonyms=Gamma2; IsoId=Q86UA6-3; Sequence=VSP_016408; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be due to an intron retention.; Name=4; Synonyms=Gamma1; IsoId=Q86UA6-4; Sequence=VSP_016407, VSP_016409; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=Delta2; IsoId=Q86UA6-5; Sequence=VSP_016403, VSP_016405; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; Synonyms=Delta3; IsoId=Q86UA6-6; Sequence=VSP_016404, VSP_016405; Name=7; Synonyms=Delta1, Delta 4; IsoId=Q86UA6-7; Sequence=VSP_016402, VSP_016406; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=8; IsoId=Q86UA6-8; Sequence=VSP_045356; Note=No experimental confirmation available.; Name=9; IsoId=Q86UA6-9; Sequence=VSP_046795; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Nucleus, PML body.


uniprotID: Q7Z7F7
geneSymbol: MRPL55
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;5OOL;5OOM;
length: 128
go: ENSG00000162910;
snps: rs822730 rs35265990
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.
name:
39S ribosomal protein L55, mitochondrial (L55mt) (MRP-L55) (Mitochondrial large ribosomal subunit protein bL31m) (Mitochondrial large ribosomal subunit protein mL55)

sequence:
MAAVGSLLGRLRQSTVKATGPALRRLHTSSWRADSSRASLTRVHRQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPIDLDTLSPEERRARLRKREAQLQSRKEYEQELSDDLHVERYRQFWTRTKK

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z7F7-1; Sequence=Displayed; Name=2; IsoId=Q7Z7F7-2; Sequence=VSP_022477; Note=No experimental confirmation available.; 


uniprotID: Q5EBL4
geneSymbol: RILPL1
name: RILP-like protein 1 (Rab-interacting lysosomal-like protein 1)
length: 403
go: ENSG00000188026;
sequence:

opentargets:
centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; dynein light intermediate chain binding [GO:0051959]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445]; regulation of neuron death [GO:1901214]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5EBL4-1; Sequence=Displayed; Name=2; IsoId=Q5EBL4-2; Sequence=VSP_027606, VSP_027608; Note=No experimental confirmation available.; Name=3; IsoId=Q5EBL4-3; Sequence=VSP_027605, VSP_027607; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14668488}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}.


uniprotID: Q0D2K3
geneSymbol: RIPPLY1
name: Protein ripply1
length: 151
go: ENSG00000147223;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
sequence:
MDSAACAAAATPVPALALALAPDLAQAPLALPGLLSPSCLLSSGQEVNGSERGTCLWRPWLSSTNDSPRQMRKLVDLAAGGATAAEVTKAESKFHHPVRLFWPKSRSFDYLYSAGEILLQNFPVQATINLYEDSDSEEEEEDEEQEDEEEK

opentargets:
nucleus [GO:0005634]; embryonic pattern specification [GO:0009880]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; somite rostral/caudal axis specification [GO:0032525]; somite specification [GO:0001757]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15772651}; IsoId=Q0D2K3-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=2 {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:15772651}; IsoId=Q0D2K3-2; Sequence=VSP_052555; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q5TAB7
geneSymbol: RIPPLY2
name: Protein ripply2
length: 128
go: ENSG00000203877;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2WG80}.
sequence:
MENAGGAEGTESGAAACAATDGPTRRAGADSGYAGFWRPWVDAGGKKEEETPNHAAEAMPDGPGMTAASGKLYQFRHPVRLFWPKSKCYDYLYQEAEALLKNFPIQATISFYEDSDSEDEIEDLTCEN

opentargets:
nucleus [GO:0005634]; bone morphogenesis [GO:0060349]; determination of left/right symmetry [GO:0007368]; negative regulation of transcription by RNA polymerase II [GO:0000122]; Notch signaling pathway [GO:0007219]; ossification [GO:0001503]; post-anal tail morphogenesis [GO:0036342]; somite rostral/caudal axis specification [GO:0032525]; somitogenesis [GO:0001756]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:14574404, ECO:0000269|PubMed:15489334}; IsoId=Q5TAB7-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=2 {ECO:0000269|PubMed:14574404}; IsoId=Q5TAB7-2; Sequence=VSP_052556; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q7LG56
geneSymbol: RRM2B
reactome: R-HSA-499943;R-HSA-5628897;
pdb: 2VUX;3HF1;4DJN;
length: 351
go: ENSG00000048392;
drug: DB00242;
name:
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; deoxyribonucleoside triphosphate metabolic process [GO:0009200]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA repair [GO:0006281]; kidney development [GO:0001822]; mitochondrial DNA replication [GO:0006264]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; renal system process [GO:0003014]; response to amine [GO:0014075]; response to oxidative stress [GO:0006979]

snps:
rs387906892 rs515726182 rs267607025 rs267607024 rs515726191 rs121918308 rs515726196 rs121918309 rs182614164 rs515726198 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q7LG56-1; Sequence=Displayed; Name=2; Synonyms=Long form; IsoId=Q7LG56-2; Sequence=VSP_017670; Name=3; Synonyms=Short form gamma; IsoId=Q7LG56-3; Sequence=VSP_017669; Name=4; Synonyms=Short form beta; IsoId=Q7LG56-4; Sequence=VSP_017668; Name=5; Synonyms=Short form; IsoId=Q7LG56-5; Sequence=VSP_017671, VSP_017672; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; IsoId=Q7LG56-6; Sequence=VSP_053585; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.


uniprotID: P23921
geneSymbol: RRM1
reactome: R-HSA-499943;
pdb: 2WGH;3HNC;3HND;3HNE;3HNF;4X3V;5D1Y;5TUS;6AUI;
length: 792
go: ENSG00000167325;
drug: DB00242;DB00631;DB01073;DB05420;DB00441;DB01005;DB05003;
snps: rs2228123 rs2229196
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleoside-diphosphate reductase subunit M1) (Ribonucleotide reductase large subunit)

sequence:

opentargets:
cell projection [GO:0042995]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nuclear envelope [GO:0005635]; ribonucleoside-diphosphate reductase complex [GO:0005971]; ATP binding [GO:0005524]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [GO:0004748]; cell proliferation in forebrain [GO:0021846]; deoxyribonucleotide biosynthetic process [GO:0009263]; DNA replication [GO:0006260]; male gonad development [GO:0008584]; mitotic cell cycle [GO:0000278]; protein heterotetramerization [GO:0051290]; pyrimidine nucleobase metabolic process [GO:0006206]; response to ionizing radiation [GO:0010212]; retina development in camera-type eye [GO:0060041]


uniprotID: Q9H1E1
geneSymbol: RNASE7
reactome: R-HSA-6803157;
pdb: 2HKY;
name: Ribonuclease 7 (RNase 7) (EC 3.1.27.-) (Skin-derived antimicrobial protein 2) (SAP-2)
length: 156
go: ENSG00000165799;
snps: rs1263872 rs1243469
sequence:
MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; endonuclease activity [GO:0004519]; lipopolysaccharide binding [GO:0001530]; nucleic acid binding [GO:0003676]; peptidoglycan binding [GO:0042834]; ribonuclease activity [GO:0004540]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; defense response to fungus [GO:0050832]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response [GO:0045087]; membrane disruption in other organism [GO:0051673]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:25075772}. Note=Detected in urine. {ECO:0000269|PubMed:25075772}.


uniprotID: Q15835
geneSymbol: GRK1
reactome: R-HSA-2514859;
pdb: 5AFP;
name: Rhodopsin kinase (RK) (EC 2.7.11.14) (G protein-coupled receptor kinase 1)
length: 563
go: ENSG00000185974;
sequence:

opentargets:
photoreceptor disc membrane [GO:0097381]; ATP binding [GO:0005524]; G protein-coupled receptor kinase activity [GO:0004703]; protein kinase activity [GO:0004672]; rhodopsin kinase activity [GO:0050254]; protein autophosphorylation [GO:0046777]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of rhodopsin mediated signaling pathway [GO:0022400]; rhodopsin mediated signaling pathway [GO:0016056]; visual perception [GO:0007601]

snps:
rs542688076 rs572803634 rs375409897 rs777094000 rs570621429 rs750619057 rs771561763 rs779749742 rs553969577 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}.


uniprotID: P62906
geneSymbol: RPL10A
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
length: 217
go: ENSG00000198755;
snps: rs17838763
name:
60S ribosomal protein L10a (CSA-19) (Large ribosomal subunit protein uL1) (Neural precursor cell expressed developmentally down-regulated protein 6) (NEDD-6)

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of LSU-rRNA [GO:0000470]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P52198
geneSymbol: RND2
length: 227
go: ENSG00000108830;
name:
Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2)

sequence:

opentargets:
acrosomal membrane [GO:0002080]; cell cortex [GO:0005938]; cell division site [GO:0032153]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; intracellular membrane-bounded organelle [GO:0043231]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; protein N-terminus binding [GO:0047485]; actin filament bundle assembly [GO:0051017]; actin filament organization [GO:0007015]; establishment or maintenance of actin cytoskeleton polarity [GO:0030950]; positive regulation of collateral sprouting [GO:0048672]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell migration [GO:0030334]; regulation of cell shape [GO:0008360]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Colocalizes with RACGAP1 in Golgi-derived proacrosomal vesicles and the acrosome. {ECO:0000269|PubMed:12590651}.


uniprotID: Q9Y3C5
geneSymbol: RNF11
name: RING finger protein 11
length: 154
go: ENSG00000123091;
snps: rs12077069
sequence:
MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPVYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN

opentargets:
early endosome [GO:0005769]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; recycling endosome [GO:0055037]; ubiquitin ligase complex [GO:0000151]; DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000269|PubMed:16123141}.


uniprotID: Q9NVW2
geneSymbol: RLIM
reactome: R-HSA-983168;
length: 624
go: ENSG00000131263;
snps: rs786205133
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19117995, ECO:0000269|PubMed:19164295}.
name:
E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptional repressor complex [GO:0017053]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; random inactivation of X chromosome [GO:0060816]; regulation of dosage compensation by inactivation of X chromosome [GO:1900095]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NVW2-1; Sequence=Displayed; Name=2; IsoId=Q9NVW2-2; Sequence=VSP_055428, VSP_055429; Note=No experimental confirmation available.; 


uniprotID: Q9BXT8
geneSymbol: RNF17
pdb: 2EQK;
name: RING finger protein 17 (Tudor domain-containing protein 4)
length: 1623
go: ENSG00000132972;
snps: rs1451568 rs9581180 rs9507413 rs10161760 rs9511451 rs3783082 rs9507425
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; multicellular organism development [GO:0007275]; spermatid development [GO:0007286]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9BXT8-3; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9BXT8-1; Sequence=VSP_033073, VSP_033074; Name=3; IsoId=Q9BXT8-2; Sequence=VSP_005753, VSP_005754; Name=4; IsoId=Q9BXT8-4; Sequence=VSP_033076; Name=5; IsoId=Q9BXT8-5; Sequence=VSP_033075; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly found in the cytoplasm. Component of a nuage in male germ cells (an electron-dense spherical cytoplasmic body present in late pachytene and diplotene spermatocytes and in elonging spermatids) (By similarity). {ECO:0000250}.


uniprotID: Q9Y225
geneSymbol: RNF24
pdb: 2EP4;
name: RING finger protein 24
length: 148
go: ENSG00000101236;
sequence:
MSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQAHKEFYAYKQVILKEKVKELNLHELCAVCLEDFKPRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLHSKQDRGPPQGPLPGAENIV

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y225-1; Sequence=Displayed; Name=2; IsoId=Q9Y225-2; Sequence=VSP_041026; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17850865}; Single-pass membrane protein {ECO:0000269|PubMed:17850865}.


uniprotID: Q9BXB4
geneSymbol: OSBPL11
pdb: 2D9X;
name: Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)
length: 747
go: ENSG00000144909;
snps: rs746035150
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; lipid binding [GO:0008289]; sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]; fat cell differentiation [GO:0045444]; positive regulation of sequestering of triglyceride [GO:0010890]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:20599956}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:20599956}. Note=Localizes at the Golgi-late endosome interface.


uniprotID: P39656
geneSymbol: DDOST
reactome: R-HSA-1799339;R-HSA-446203;R-HSA-6798695;R-HSA-879415;
length: 456
go: ENSG00000244038;
snps: rs537816 rs387906831
name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)

sequence:

opentargets:
azurophil granule membrane [GO:0035577]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; neutrophil degranulation [GO:0043312]; protein glycosylation [GO:0006486]; protein N-linked glycosylation [GO:0006487]; protein N-linked glycosylation via asparagine [GO:0018279]; response to cytokine [GO:0034097]; T cell activation [GO:0042110]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P39656-1; Sequence=Displayed; Name=2; IsoId=P39656-2; Sequence=VSP_055498; Note=No experimental confirmation available.; Name=3; IsoId=P39656-3; Sequence=VSP_055499; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q29381}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q29381}.


uniprotID: Q5VV17
geneSymbol: OTUD1
pdb: 4BOP;
name: OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)
length: 481
go: ENSG00000165312;
sequence:

opentargets:
thiol-dependent ubiquitin-specific protease activity [GO:0004843]; protein K63-linked deubiquitination [GO:0070536]


uniprotID: Q9H4L5
geneSymbol: OSBPL3
reactome: R-HSA-192105;
name: Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)
length: 887
go: ENSG00000070882;
snps: rs11768296
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; filopodium tip [GO:0032433]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear membrane [GO:0031965]; perinuclear endoplasmic reticulum [GO:0097038]; plasma membrane [GO:0005886]; cholesterol binding [GO:0015485]; lipid binding [GO:0008289]; sterol binding [GO:0032934]; sterol transporter activity [GO:0015248]; bile acid biosynthetic process [GO:0006699]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1a; IsoId=Q9H4L5-1; Sequence=Displayed; Name=1b; IsoId=Q9H4L5-2; Sequence=VSP_008219; Name=1c; IsoId=Q9H4L5-3; Sequence=VSP_008220; Name=1d; IsoId=Q9H4L5-4; Sequence=VSP_008219, VSP_008220; Name=2a; IsoId=Q9H4L5-5; Sequence=VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2b; IsoId=Q9H4L5-6; Sequence=VSP_008219, VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2c; IsoId=Q9H4L5-7; Sequence=VSP_008220, VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=2d; IsoId=Q9H4L5-8; Sequence=VSP_008219, VSP_008220, VSP_008221, VSP_008222; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000269|PubMed:16143324}. Cytoplasm, cytosol {ECO:0000269|PubMed:16143324}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}; Peripheral membrane protein {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:16143324, ECO:0000269|PubMed:18270267, ECO:0000269|PubMed:25447204}. Cell projection, filopodium tip {ECO:0000269|PubMed:18270267}. Nucleus membrane {ECO:0000269|PubMed:16143324}; Peripheral membrane protein {ECO:0000305}.


uniprotID: Q96BN8
geneSymbol: OTULIN
reactome: R-HSA-5357905;R-HSA-8866652;
pdb: 3ZNV;3ZNX;3ZNZ;4KSJ;4KSK;4KSL;4OYK;4P0B;5OE7;
length: 352
go: ENSG00000154124;
snps: rs11953822 rs9312870 rs886037887 rs886037885 rs9312870
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23746843}.
name:
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; LUBAC complex [GO:0071797]; cysteine-type peptidase activity [GO:0008234]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; innate immune response [GO:0045087]; negative regulation of inflammatory response [GO:0050728]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070431]; protein linear deubiquitination [GO:1990108]; regulation of canonical Wnt signaling pathway [GO:0060828]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055]


uniprotID: Q99572
geneSymbol: P2RX7
reactome: R-HSA-139853;R-HSA-418346;R-HSA-844456;
name: P2X purinoceptor 7 (P2X7) (ATP receptor) (P2Z receptor) (Purinergic receptor)
length: 595
go: ENSG00000089041;
sequence:

opentargets:
bleb [GO:0032059]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; integral component of nuclear inner membrane [GO:0005639]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; ATP binding [GO:0005524]; ATP-gated ion channel activity [GO:0035381]; extracellularly ATP-gated cation channel activity [GO:0004931]; lipopolysaccharide binding [GO:0001530]; protein homodimerization activity [GO:0042803]; purinergic nucleotide receptor activity [GO:0001614]; signaling receptor binding [GO:0005102]; activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; bleb assembly [GO:0032060]; blood coagulation [GO:0007596]; calcium ion transmembrane transport [GO:0070588]; calcium-mediated signaling using extracellular calcium source [GO:0035585]; cation transport [GO:0006812]; cell morphogenesis [GO:0000902]; cell surface receptor signaling pathway [GO:0007166]; cell surface receptor signaling pathway involved in cell-cell signaling [GO:1905114]; cellular response to ATP [GO:0071318]; cellular response to dsRNA [GO:0071359]; ceramide biosynthetic process [GO:0046513]; collagen metabolic process [GO:0032963]; defense response to Gram-positive bacterium [GO:0050830]; extrinsic apoptotic signaling pathway [GO:0097191]; homeostasis of number of cells within a tissue [GO:0048873]; inflammatory response [GO:0006954]; ion transmembrane transport [GO:0034220]; membrane depolarization [GO:0051899]; membrane protein ectodomain proteolysis [GO:0006509]; mitochondrion organization [GO:0007005]; NAD transport [GO:0043132]; negative regulation of bone resorption [GO:0045779]; negative regulation of cell volume [GO:0045794]; negative regulation of MAPK cascade [GO:0043409]; phagolysosome assembly [GO:0001845]; phospholipid scrambling [GO:0017121]; phospholipid transfer to membrane [GO:0006649]; phospholipid translocation [GO:0045332]; pore complex assembly [GO:0046931]; positive regulation of bleb assembly [GO:1904172]; positive regulation of bone mineralization [GO:0030501]; positive regulation of calcium ion transport into cytosol [GO:0010524]; positive regulation of cytolysis [GO:0045919]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of gamma-aminobutyric acid secretion [GO:0014054]; positive regulation of gene expression [GO:0010628]; positive regulation of glutamate secretion [GO:0014049]; positive regulation of glycolytic process [GO:0045821]; positive regulation of interleukin-1 alpha secretion [GO:0050717]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of ion transmembrane transport [GO:0034767]; positive regulation of lymphocyte apoptotic process [GO:0070230]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of prostaglandin secretion [GO:0032308]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; protein catabolic process [GO:0030163]; protein complex oligomerization [GO:0051259]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; purinergic nucleotide receptor signaling pathway [GO:0035590]; reactive oxygen species metabolic process [GO:0072593]; regulation of killing of cells of other organism [GO:0051709]; regulation of sodium ion transport [GO:0002028]; release of sequestered calcium ion into cytosol [GO:0051209]; response to ATP [GO:0033198]; response to calcium ion [GO:0051592]; response to electrical stimulus [GO:0051602]; response to fluid shear stress [GO:0034405]; response to ischemia [GO:0002931]; response to lipopolysaccharide [GO:0032496]; response to mechanical stimulus [GO:0009612]; response to zinc ion [GO:0010043]; sensory perception of pain [GO:0019233]; skeletal system morphogenesis [GO:0048705]; synaptic vesicle exocytosis [GO:0016079]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; vesicle budding from membrane [GO:0006900]

snps:
rs17525809 rs28360445 rs201668926 rs150235326 rs28360447 rs208294 rs140915863 rs149639375 rs16950860 rs7958311 rs7958316 rs146725537 rs28360457 rs1718119 rs2230911 rs201921967 rs10160951 rs28360459 rs2230912 rs3751143 rs2230913 rs34219304 rs201256156 rs34567077 rs1653624 rs28360460 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=A; IsoId=Q99572-1; Sequence=Displayed; Name=B; Synonyms=Delta-C, cytoplasmic tail deleted; IsoId=Q99572-2; Sequence=VSP_047784, VSP_047785; Note=Predominant form in many tissues.; Name=C; IsoId=Q99572-3; Sequence=VSP_047781, VSP_047782; Name=D; IsoId=Q99572-4; Sequence=VSP_047777, VSP_047780; Name=E; IsoId=Q99572-5; Sequence=VSP_047783, VSP_047784, VSP_047785; Name=F; IsoId=Q99572-6; Sequence=VSP_047778, VSP_047779; Name=G; IsoId=Q99572-7; Sequence=VSP_047776, VSP_047784, VSP_047785; Name=H; Synonyms=Delta-TM1; IsoId=Q99572-8; Sequence=VSP_047776; Note=Non-functional channel.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12107182, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:28326637}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: O95747
geneSymbol: OXSR1
pdb: 2V3S;2VWI;3DAK;
name: Serine/threonine-protein kinase OSR1 (EC 2.7.11.1) (Oxidative stress-responsive 1 protein)
length: 527
go: ENSG00000172939;
snps: rs6599079 rs35295772
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22361696}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; intracellular signal transduction [GO:0035556]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to oxidative stress [GO:0006979]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]


uniprotID: Q8IVL5
geneSymbol: P3H2
reactome: R-HSA-1650814;
length: 708
go: ENSG00000090530;
drug: DB00172;DB00139;DB00126;
snps: rs724159988
name:
Prolyl 3-hydroxylase 2 (EC 1.14.11.7) (Leprecan-like protein 1) (Myxoid liposarcoma-associated protein 4)

sequence:

opentargets:
basement membrane [GO:0005604]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; Golgi apparatus [GO:0005794]; sarcoplasmic reticulum [GO:0016529]; iron ion binding [GO:0005506]; L-ascorbic acid binding [GO:0031418]; procollagen-proline 3-dioxygenase activity [GO:0019797]; collagen metabolic process [GO:0032963]; negative regulation of cell proliferation [GO:0008285]; peptidyl-proline hydroxylation [GO:0019511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IVL5-1; Sequence=Displayed; Name=2; IsoId=Q8IVL5-2; Sequence=VSP_053814; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:15063763}. Sarcoplasmic reticulum {ECO:0000305|PubMed:15063763}. Golgi apparatus {ECO:0000269|PubMed:15063763}.


uniprotID: P68402
geneSymbol: PAFAH1B2
reactome: R-HSA-6798695;R-HSA-6811436;
pdb: 1VYH;
length: 229
go: ENSG00000168092;
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Platelet-activating factor acetylhydrolase IB subunit beta (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; fibrillar center [GO:0001650]; ficolin-1-rich granule lumen [GO:1904813]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; secretory granule lumen [GO:0034774]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; phospholipase A2 activity [GO:0004623]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; brain development [GO:0007420]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; neutrophil degranulation [GO:0043312]; positive regulation of macroautophagy [GO:0016239]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P68402-1; Sequence=Displayed; Name=2; IsoId=P68402-2; Sequence=VSP_042896; Name=3; IsoId=P68402-3; Sequence=VSP_043217; Name=4; IsoId=P68402-4; Sequence=VSP_044680; 


uniprotID: Q15102
geneSymbol: PAFAH1B3
reactome: R-HSA-6811436;
length: 231
go: ENSG00000079462;
snps: rs1043818
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Platelet-activating factor acetylhydrolase IB subunit gamma (EC 3.1.1.47) (PAF acetylhydrolase 29 kDa subunit) (PAF-AH 29 kDa subunit) (PAF-AH subunit gamma) (PAFAH subunit gamma)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; 1-alkyl-2-acetylglycerophosphocholine esterase activity [GO:0003847]; identical protein binding [GO:0042802]; phospholipase A2 activity [GO:0004623]; platelet-activating factor acetyltransferase activity [GO:0047179]; protein heterodimerization activity [GO:0046982]; brain development [GO:0007420]; lipid catabolic process [GO:0016042]; lipid metabolic process [GO:0006629]; nervous system development [GO:0007399]; spermatogenesis [GO:0007283]


uniprotID: Q9BY11
geneSymbol: PACSIN1
reactome: R-HSA-8856828;
pdb: 3HAH;3HAI;3Q84;3QNI;
name: Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1)
length: 444
go: ENSG00000124507;
snps: rs41312309
sequence:

opentargets:
axon terminus [GO:0043679]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; synapse [GO:0045202]; cytoskeletal protein binding [GO:0008092]; phospholipid binding [GO:0005543]; actin filament organization [GO:0007015]; cytoskeleton organization [GO:0007010]; neuron projection morphogenesis [GO:0048812]; plasma membrane tubulation [GO:0097320]; positive regulation of dendrite development [GO:1900006]; protein localization to membrane [GO:0072657]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.


uniprotID: Q8NDF8
geneSymbol: TENT4B
length: 572
go: ENSG00000121274;
name:
Non-canonical poly(A) RNA polymerase PAPD5 (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal nucleotidyltransferase 4B) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; TRAMP complex [GO:0031499]; DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; carbohydrate homeostasis [GO:0033500]; cell cycle [GO:0007049]; cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA polyadenylation [GO:0006378]; ncRNA polyadenylation [GO:0043629]; ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [GO:0043630]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; rRNA processing [GO:0006364]; snoRNA polyadenylation [GO:0071050]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8NDF8-1; Sequence=Displayed; Name=2; IsoId=Q8NDF8-2; Sequence=VSP_012734, VSP_012736; Note=No experimental confirmation available.; Name=3; IsoId=Q8NDF8-3; Sequence=VSP_012735, VSP_012737; Name=4; IsoId=Q8NDF8-4; Sequence=VSP_012732, VSP_012733; Note=No experimental confirmation available.; Name=5; IsoId=Q8NDF8-5; Sequence=VSP_046989, VSP_046990, VSP_012735; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}. Nucleus, nucleolus {ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:23376078}. Cytoplasm {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:28383716}. Note=Predominantly expressed in the cytoplasm (PubMed:18172165).


uniprotID: Q5XG87
geneSymbol: TENT4A
reactome: R-HSA-6802952;
length: 772
go: ENSG00000112941;
snps: rs28381415 rs28381418
name:
Non-canonical poly(A) RNA polymerase PAPD7 (EC 2.7.7.19) (DNA polymerase sigma) (LAK-1) (PAP-associated domain-containing protein 7) (TRAMP-like complex polyadenylate polymerase) (Terminal nucleotidyltransferase 4A) (Terminal uridylyltransferase 5) (TUTase 5) (Topoisomerase-related function protein 4-1) (TRF4-1)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; TRAMP complex [GO:0031499]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; SMC family protein binding [GO:0043221]; double-strand break repair [GO:0006302]; histone mRNA catabolic process [GO:0071044]; mitotic chromosome condensation [GO:0007076]; mRNA polyadenylation [GO:0006378]; ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [GO:0043630]; nuclear polyadenylation-dependent mRNA catabolic process [GO:0071042]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent snoRNA catabolic process [GO:0071036]; nuclear polyadenylation-dependent snRNA catabolic process [GO:0071037]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; response to drug [GO:0042493]; sister chromatid cohesion [GO:0007062]; snoRNA polyadenylation [GO:0071050]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=l; IsoId=Q5XG87-1; Sequence=Displayed; Name=2; Synonyms=s; IsoId=Q5XG87-2; Sequence=VSP_053732; Note=Exhibits poor nucleotidyl transferase activity.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm.


uniprotID: P51003
geneSymbol: PAPOLA
reactome: R-HSA-109688;R-HSA-72163;R-HSA-72187;R-HSA-77595;
name: Poly(A) polymerase alpha (PAP-alpha) (EC 2.7.7.19) (Polynucleotide adenylyltransferase alpha)
length: 745
go: ENSG00000090060;
drug: DB02153;DB01860;DB03896;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; regulation of mRNA 3'-end processing [GO:0031440]; RNA polyadenylation [GO:0043631]; termination of RNA polymerase II transcription [GO:0006369]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P51003-1; Sequence=Displayed; Name=2; IsoId=P51003-2; Sequence=VSP_012895, VSP_012896; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The 90 kDa form is nuclear while the 100 kDa and the 106 kDa forms are both nuclear and cytoplasmic.


uniprotID: Q9BWT3
geneSymbol: PAPOLG
pdb: 4LT6;
length: 736
go: ENSG00000115421;
name:
Poly(A) polymerase gamma (PAP-gamma) (EC 2.7.7.19) (Neo-poly(A) polymerase) (Neo-PAP) (Polynucleotide adenylyltransferase gamma) (SRP RNA 3'-adenylating enzyme) (Signal recognition particle RNA-adenylating enzyme) (SRP RNA-adenylating enzyme)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; mRNA polyadenylation [GO:0006378]; RNA polyadenylation [GO:0043631]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BWT3-1; Sequence=Displayed; Name=2; IsoId=Q9BWT3-2; Sequence=VSP_054379; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11287430, ECO:0000269|PubMed:11431479, ECO:0000269|PubMed:11463842}.


uniprotID: Q5QFB9
geneSymbol: PAPPA-AS1
length: 102
opentargets: endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]
name:
Protein PAPPAS (DIPLA1 antisense RNA 1) (DIPLA1 antisense gene protein 1) (DIPLA1-antisense expressed) (PAPPAS antisense RNA 1) (PAPPAS antisense gene protein 1) (PAPPAS-antisense expressed)

sequence:
MRYGFVRKKHRGLFLTTVAALPIWNPISEFVKWYKSHKLSQHCIRICGHLCQKHLDMFLSVIGQRWPIDVFSSVFDHQVSAIGSDIIWWFLKLFLVSFFFFF

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q9BYG5
geneSymbol: PARD6B
reactome: R-HSA-420029;
name: Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
length: 372
go: ENSG00000124171;
sequence:

opentargets:
apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell cortex [GO:0005938]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein kinase C binding [GO:0005080]; Rho GTPase binding [GO:0017048]; axonogenesis [GO:0007409]; bicellular tight junction assembly [GO:0070830]; cell division [GO:0051301]; cell-cell junction assembly [GO:0007043]; centrosome cycle [GO:0007098]; establishment or maintenance of cell polarity [GO:0007163]; protein-containing complex assembly [GO:0065003]; regulation of cell migration [GO:0030334]; regulation of cellular localization [GO:0060341]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BYG5-1; Sequence=Displayed; Name=2; IsoId=Q9BYG5-2; Sequence=VSP_053311, VSP_053312; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.


uniprotID: Q53GL7
geneSymbol: PARP10
reactome: R-HSA-197264;
pdb: 2DHX;3HKV;5LX6;
length: 1025
go: ENSG00000178685;
snps: rs11136344 rs11136343 rs11544989
name:
Poly [ADP-ribose] polymerase 10 (PARP-10) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 10) (ARTD10)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of gene expression [GO:0010629]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein K63-linked ubiquitination [GO:1900045]; negative regulation of viral genome replication [GO:0045071]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein poly-ADP-ribosylation [GO:0070212]; regulation of chromatin assembly [GO:0010847]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15674325}. Cytoplasm {ECO:0000269|PubMed:15674325}. Note=Shuttles between the nuclear and cytoplasmic compartment. A subpopulation concentrates in the nucleolus during late G1/S phase.


uniprotID: Q9H0J9
geneSymbol: PARP12
pdb: 2PQF;
length: 701
go: ENSG00000059378;
snps: rs34111764 rs35456446 rs17161356
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Poly [ADP-ribose] polymerase 12 (PARP-12) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 12) (ARTD12) (Zinc finger CCCH domain-containing protein 1)

sequence:

opentargets:
nucleus [GO:0005634]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; RNA binding [GO:0003723]


uniprotID: Q460N3
geneSymbol: PARP15
pdb: 3BLJ;3GEY;3V2B;4F0E;6EK3;
length: 678
go: ENSG00000173200;
snps: rs6793271 rs34383355 rs12489170
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Poly [ADP-ribose] polymerase 15 (PARP-15) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 7) (ARTD7) (B-aggressive lymphoma protein 3)

sequence:

opentargets:
nucleus [GO:0005634]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; NAD+ binding [GO:0070403]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]; protein poly-ADP-ribosylation [GO:0070212]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q460N3-1; Sequence=Displayed; Name=2; IsoId=Q460N3-2; Sequence=VSP_020971, VSP_020972; 


uniprotID: Q8N5Y8
geneSymbol: PARP16
reactome: R-HSA-197264;
pdb: 4F0D;
length: 322
go: ENSG00000138617;
snps: rs17852901
name:
Mono [ADP-ribose] polymerase PARP16 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; kinase binding [GO:0019900]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; protein serine/threonine kinase activator activity [GO:0043539]; cellular response to leukemia inhibitory factor [GO:1990830]; endoplasmic reticulum unfolded protein response [GO:0030968]; IRE1-mediated unfolded protein response [GO:0036498]; NAD biosynthesis via nicotinamide riboside salvage pathway [GO:0034356]; negative regulation of cell death [GO:0060548]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N5Y8-1; Sequence=Displayed; Name=2; IsoId=Q8N5Y8-2; Sequence=VSP_020973; Note=No experimental confirmation available.; Name=3; IsoId=Q8N5Y8-3; Sequence=VSP_020974; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type IV membrane protein {ECO:0000269|PubMed:22701565}.


uniprotID: Q9NWS1
geneSymbol: PARPBP
name: PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP)
length: 579
go: ENSG00000185480;
snps: rs12227879
sequence:

opentargets:
chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q9NWS1-1; Sequence=Displayed; Name=2; IsoId=Q9NWS1-2; Sequence=VSP_023588; Name=3; IsoId=Q9NWS1-3; Sequence=VSP_023591, VSP_023592; Note=No experimental confirmation available.; Name=4; IsoId=Q9NWS1-4; Sequence=VSP_023589, VSP_023590; Note=No experimental confirmation available.; Name=5; IsoId=Q9NWS1-5; Sequence=VSP_023587; Note=No experimental confirmation available.; Name=6; IsoId=Q9NWS1-6; Sequence=VSP_023594, VSP_023595; Note=No experimental confirmation available.; Name=7; IsoId=Q9NWS1-7; Sequence=VSP_023593, VSP_023596, VSP_023597; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.


uniprotID: P55085
geneSymbol: F2RL1
reactome: R-HSA-375276;R-HSA-416476;
pdb: 5NDD;5NDZ;5NJ6;
length: 397
snps: rs2243072 rs616235 rs2243062 rs2243083
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Proteinase-activated receptor 2 (PAR-2) (Coagulation factor II receptor-like 1) (G-protein coupled receptor 11) (Thrombin receptor-like 1) [Cleaved into: Proteinase-activated receptor 2, alternate cleaved 1; Proteinase-activated receptor 2, alternate cleaved 2]

sequence:

opentargets:
early endosome [GO:0005769]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; pseudopodium [GO:0031143]; G protein-coupled receptor activity [GO:0004930]; G-protein alpha-subunit binding [GO:0001965]; G-protein beta-subunit binding [GO:0031681]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; thrombin-activated receptor activity [GO:0015057]; blood coagulation [GO:0007596]; cell-cell junction maintenance [GO:0045217]; chemokine (C-C motif) ligand 2 secretion [GO:0035926]; chemokine secretion [GO:0090195]; defense response to virus [GO:0051607]; establishment of endothelial barrier [GO:0061028]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interferon-gamma secretion [GO:0072643]; interleukin-1 beta secretion [GO:0050702]; interleukin-10 secretion [GO:0072608]; leukocyte migration [GO:0050900]; leukocyte proliferation [GO:0070661]; mature conventional dendritic cell differentiation [GO:0097029]; negative regulation of chemokine secretion [GO:0090198]; negative regulation of JNK cascade [GO:0046329]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; neutrophil activation [GO:0042119]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of blood vessel diameter [GO:0097755]; positive regulation of cell migration [GO:0030335]; positive regulation of chemotaxis [GO:0050921]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway [GO:0051482]; positive regulation of eosinophil degranulation [GO:0043311]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glomerular filtration [GO:0003104]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of interleukin-8 secretion [GO:2000484]; positive regulation of JNK cascade [GO:0046330]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of neutrophil mediated killing of gram-negative bacterium [GO:0070963]; positive regulation of phagocytosis, engulfment [GO:0060100]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of pseudopodium assembly [GO:0031274]; positive regulation of renin secretion into blood stream [GO:1900135]; positive regulation of Rho protein signal transduction [GO:0035025]; positive regulation of superoxide anion generation [GO:0032930]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of blood coagulation [GO:0030193]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of JNK cascade [GO:0046328]; T cell activation involved in immune response [GO:0002286]


uniprotID: Q6UY27
geneSymbol: PATE2
name: Prostate and testis expressed protein 2 (PATE-like protein M) (PATE-M)
length: 113
go: ENSG00000196844;
opentargets: extracellular space [GO:0005615]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MLVLFLLGTVFLLCPYWGELHDPIKATEIMCYECKKYHLGLCYGVMTSCSLKHKQSCAVENFYILTRKGQSMYHYSKLSCMTSCEDINFLGFTKRVELICCDHSNYCNLPEGV

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6UY27-1; Sequence=Displayed; Name=2; IsoId=Q6UY27-2; Sequence=VSP_035810; 


uniprotID: Q6UWI2
geneSymbol: PARM1
name: Prostate androgen-regulated mucin-like protein 1 (PARM-1)
length: 310
go: ENSG00000169116;
snps: rs3822109
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; positive regulation of telomerase activity [GO:0051973]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}. Golgi apparatus membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}. Endosome membrane {ECO:0000269|PubMed:18027867}; Single-pass type I membrane protein {ECO:0000269|PubMed:18027867}.


uniprotID: Q8IV76
geneSymbol: PASD1
length: 773
go: ENSG00000166049;
snps: rs5924658
name:
Circadian clock protein PASD1 (Cancer/testis antigen 63) (CT63) (OX-TES-1) (PAS domain-containing protein 1)

sequence:

opentargets:
Cry-Per complex [GO:1990512]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; transcription coactivator binding [GO:0001223]; negative regulation of circadian rhythm [GO:0042754]; negative regulation of transcription, DNA-templated [GO:0045892]; rhythmic process [GO:0048511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=PASD1_v2; IsoId=Q8IV76-1; Sequence=Displayed; Name=2; Synonyms=PASD1_v1; IsoId=Q8IV76-2; Sequence=VSP_027663, VSP_027664; Note=Due to intron retention.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.


uniprotID: C9JE40
geneSymbol: PATL2
name: Protein PAT1 homolog 2 (PAT1-like protein 2) (Protein PAT1 homolog a) (Pat1a) (hPat1a)
length: 543
go: ENSG00000229474;
snps: rs8026845 rs569729547 rs1011539285 rs1397500378
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; P-body [GO:0000932]; RNA binding [GO:0003723]; cytoplasmic mRNA processing body assembly [GO:0033962]; deadenylation-dependent decapping of nuclear-transcribed mRNA [GO:0000290]; negative regulation of cytoplasmic mRNA processing body assembly [GO:0010607]; negative regulation of translation [GO:0017148]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:28965849}. Nucleus {ECO:0000250|UniProtKB:A2ARM1}.


uniprotID: Q9Y5B6
geneSymbol: PAXBP1
name: PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1)
length: 917
go: ENSG00000159086;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription factor binding [GO:0008134]; muscle organ development [GO:0007517]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of histone methylation [GO:0031062]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of skeletal muscle satellite cell proliferation [GO:0014842]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=A; IsoId=Q9Y5B6-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9Y5B6-2; Sequence=VSP_004267; Name=3; Synonyms=C; IsoId=Q9Y5B6-3; Sequence=VSP_004263, VSP_004264; Name=4; Synonyms=D; IsoId=Q9Y5B6-4; Sequence=VSP_004265, VSP_004266; Note=Most abundantly expressed isoform, at mRNA level according to PubMed:11707072, despite the presence of a premature stop codon in the mRNA that may lead to nonsense-mediated mRNA decay.; 


uniprotID: Q6ZW49
geneSymbol: PAXIP1
reactome: R-HSA-5617472;R-HSA-5693571;
pdb: 3SQD;
name: PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
length: 1069
go: ENSG00000157212;
snps: rs3501
sequence:

opentargets:
chromosome [GO:0005694]; histone methyltransferase complex [GO:0035097]; MLL3/4 complex [GO:0044666]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; adipose tissue development [GO:0060612]; chorion development [GO:0060717]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA recombination [GO:0006310]; double-strand break repair via nonhomologous end joining [GO:0006303]; endothelial cell migration [GO:0043542]; histone H3-K4 methylation [GO:0051568]; positive regulation of histone acetylation [GO:0035066]; positive regulation of histone H3-K36 methylation [GO:0000416]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of isotype switching [GO:0045830]; positive regulation of isotype switching to IgG isotypes [GO:0048304]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of response to DNA damage stimulus [GO:2001022]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; regulation of cell cycle G2/M phase transition [GO:1902749]; response to ionizing radiation [GO:0010212]; vasculogenesis [GO:0001570]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZW49-6; Sequence=Displayed; Name=2; IsoId=Q6ZW49-1; Sequence=VSP_040300; Name=3; IsoId=Q6ZW49-2; Sequence=VSP_040303; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:Q6NZQ4}. Chromosome {ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115}. Note=Localizes to DNA damage foci upon ionizing radiation. {ECO:0000269|PubMed:15456759, ECO:0000269|PubMed:17690115}.


uniprotID: P23759
geneSymbol: PAX7
name: Paired box protein Pax-7 (HuP1)
length: 505
go: ENSG00000009709;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P47239}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding [GO:0000983]; anatomical structure morphogenesis [GO:0009653]; cartilage development [GO:0051216]; chromatin remodeling [GO:0006338]; dorsal/ventral neural tube patterning [GO:0021904]; embryonic skeletal system development [GO:0048706]; muscle tissue morphogenesis [GO:0060415]; negative regulation of apoptotic process [GO:0043066]; neuron fate commitment [GO:0048663]; positive regulation of histone methylation [GO:0031062]; positive regulation of myoblast proliferation [GO:2000288]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cell fate commitment [GO:0010453]; regulation of protein binding [GO:0043393]; skeletal muscle satellite cell commitment [GO:0014813]; skeletal muscle tissue regeneration [GO:0043403]; spinal cord association neuron differentiation [GO:0021527]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=P23759-3; Sequence=Displayed; Name=1; Synonyms=Long; IsoId=P23759-1; Sequence=VSP_057679; Name=2; Synonyms=Short; IsoId=P23759-2; Sequence=VSP_057678, VSP_057679; 


