# annotation

uniprotID: O75955
geneSymbol: FLOT1
reactome: R-HSA-8849932;
name: Flotillin-1
length: 427
go: ENSG00000137312;
snps: rs3180825
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell adherens junction [GO:0005913]; cell-cell contact zone [GO:0044291]; cell-cell junction [GO:0005911]; centriolar satellite [GO:0034451]; cytoplasmic vesicle [GO:0031410]; dopaminergic synapse [GO:0098691]; early endosome [GO:0005769]; endosome [GO:0005768]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; sarcolemma [GO:0042383]; uropod [GO:0001931]; ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; axonogenesis [GO:0007409]; cellular response to exogenous dsRNA [GO:0071360]; dsRNA transport [GO:0033227]; extracellular matrix disassembly [GO:0022617]; membrane raft assembly [GO:0001765]; plasma membrane raft assembly [GO:0044854]; positive regulation of cell adhesion molecule production [GO:0060355]; positive regulation of cell junction assembly [GO:1901890]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of cytokine production [GO:0001819]; positive regulation of endocytosis [GO:0045807]; positive regulation of heterotypic cell-cell adhesion [GO:0034116]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of synaptic transmission, dopaminergic [GO:0032226]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; protein homooligomerization [GO:0051260]; protein kinase C signaling [GO:0070528]; protein localization to membrane raft [GO:1903044]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; regulation of neurotransmitter uptake [GO:0051580]; regulation of receptor internalization [GO:0002090]; regulation of Rho protein signal transduction [GO:0035023]; response to endoplasmic reticulum stress [GO:0034976]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75955-1; Sequence=Displayed; Name=2; IsoId=O75955-2; Sequence=VSP_056227; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000269|PubMed:17081065}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity). {ECO:0000250|UniProtKB:O08917, ECO:0000269|PubMed:17081065}.


uniprotID: Q14254
geneSymbol: FLOT2
reactome: R-HSA-8849932;
name: Flotillin-2 (Epidermal surface antigen) (ESA) (Membrane component chromosome 17 surface marker 1)
length: 428
go: ENSG00000132589;
snps: rs3736238
sequence:

opentargets:
acrosomal membrane [GO:0002080]; anchored component of presynaptic active zone membrane [GO:0099029]; basolateral plasma membrane [GO:0016323]; caveola [GO:0005901]; cell-cell adherens junction [GO:0005913]; cell-cell contact zone [GO:0044291]; cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; flotillin complex [GO:0016600]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; uropod [GO:0001931]; vesicle [GO:0031982]; ionotropic glutamate receptor binding [GO:0035255]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; anterograde dendritic transport [GO:0098937]; cell adhesion [GO:0007155]; epidermis development [GO:0008544]; membrane raft assembly [GO:0001765]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of gene expression [GO:0010629]; positive regulation of establishment of T cell polarity [GO:1903905]; protein localization to plasma membrane [GO:0072659]; protein localization to plasma membrane raft [GO:0044860]; protein stabilization [GO:0050821]; regulation of myoblast differentiation [GO:0045661]; regulation of postsynaptic membrane neurotransmitter receptor levels [GO:0099072]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Membrane-associated protein of caveolae.


uniprotID: Q9UGQ2
geneSymbol: CACFD1
reactome: R-HSA-112308;
name: Calcium channel flower homolog (Calcium channel flower domain-containing protein 1)
length: 172
go: ENSG00000160325;
opentargets: integral component of membrane [GO:0016021]; vesicle-mediated transport [GO:0016192]
snps: rs3124765
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MSSSGGAPGASASSAPPAQEEGMTWWYRWLCRLSGVLGAVSCAISGLFNCITIHPLNIAAGVWMIMNAFILLLCEAPFCCQFIEFANTVAEKVDRLRSWQKAVFYCGMAVVPIVISLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETLEGEL

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UGQ2-1; Sequence=Displayed; Name=2; IsoId=Q9UGQ2-2; Sequence=VSP_012997; Name=3; IsoId=Q9UGQ2-3; Sequence=VSP_012997, VSP_042522; Note=No experimental confirmation available.; Name=4; IsoId=Q9UGQ2-4; Sequence=VSP_042522; Note=No experimental confirmation available.; 


uniprotID: Q9NZU1
geneSymbol: FLRT1
reactome: R-HSA-5654687;
length: 646
name:
Leucine-rich repeat transmembrane protein FLRT1 (Fibronectin-like domain-containing leucine-rich transmembrane protein 1)

sequence:

opentargets:
cell-cell junction [GO:0005911]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; integral component of plasma membrane [GO:0005887]; neuron projection terminus [GO:0044306]; neuronal cell body membrane [GO:0032809]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; fibroblast growth factor receptor binding [GO:0005104]; protein binding, bridging [GO:0030674]; cell adhesion [GO:0007155]; dendrite development [GO:0016358]; fibroblast growth factor receptor signaling pathway [GO:0008543]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6RKD8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6RKD8}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q6RKD8}. Secreted {ECO:0000250|UniProtKB:Q6RKD8}. Cell projection {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction {ECO:0000250|UniProtKB:Q6RKD8}. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q6RKD8}.


uniprotID: O43155
geneSymbol: FLRT2
reactome: R-HSA-5654687;
length: 660
go: ENSG00000185070;
snps: rs17646457
name:
Leucine-rich repeat transmembrane protein FLRT2 (Fibronectin-like domain-containing leucine-rich transmembrane protein 2)

sequence:

opentargets:
cell-cell junction [GO:0005911]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; focal adhesion [GO:0005925]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; synapse [GO:0045202]; chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein binding, bridging [GO:0030674]; axon guidance [GO:0007411]; basement membrane organization [GO:0071711]; cell adhesion involved in heart morphogenesis [GO:0061343]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; positive regulation of synapse assembly [GO:0051965]; regulation of neuron migration [GO:2001222]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BLU0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BLU0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BLU0}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BLU0}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8BLU0}. Microsome membrane {ECO:0000250|UniProtKB:Q8BLU0}. Secreted {ECO:0000250|UniProtKB:Q8BLU0}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTV3}. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q8BLU0}.


uniprotID: Q9NZU0
geneSymbol: FLRT3
reactome: R-HSA-376176;R-HSA-5654687;
pdb: 5CMN;5CMP;
length: 649
go: ENSG00000125848;
snps: rs398124653 rs398124651 rs398124652 rs398124654 rs8120693 rs6079391 rs35253731
name:
Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin-like domain-containing leucine-rich transmembrane protein 3)

sequence:

opentargets:
axon terminus [GO:0043679]; axonal growth cone [GO:0044295]; cell junction [GO:0030054]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic membrane [GO:0099055]; plasma membrane [GO:0005886]; synaptic membrane [GO:0097060]; chemorepellent activity [GO:0045499]; fibroblast growth factor receptor binding [GO:0005104]; protein binding, bridging [GO:0030674]; protein homodimerization activity [GO:0042803]; axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; embryonic morphogenesis [GO:0048598]; fibroblast growth factor receptor signaling pathway [GO:0008543]; head development [GO:0060322]; heart development [GO:0007507]; neuron projection development [GO:0031175]; neuron projection extension [GO:1990138]; positive regulation of synapse assembly [GO:0051965]; proepicardium cell migration involved in pericardium morphogenesis [GO:0003345]; response to axon injury [GO:0048678]; synapse assembly [GO:0007416]; synaptic membrane adhesion [GO:0099560]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14706654, ECO:0000269|PubMed:26235030}; Single-pass membrane protein {ECO:0000269|PubMed:14706654, ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BGT1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BGT1}. Secreted {ECO:0000250|UniProtKB:Q8BGT1}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BGT1}. Note=Detected on dendritic punctae that colocalize in part with glutamaergic synapses, but not with GABAergic synapses. Detected on axons and at axon termini. Detected at neuronal growth cones. Proteolytic cleavage in the juxtamembrane region gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:B1H234, ECO:0000250|UniProtKB:Q8BGT1}.


uniprotID: P49771
geneSymbol: FLT3LG
reactome: R-HSA-109704;R-HSA-449836;R-HSA-5673001;
pdb: 1ETE;3QS7;3QS9;
name: Fms-related tyrosine kinase 3 ligand (Flt3 ligand) (Flt3L) (SL cytokine)
length: 235
go: ENSG00000090554;
sequence:

opentargets:
cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; intrinsic component of external side of plasma membrane [GO:0031233]; membrane [GO:0016020]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; cytokine activity [GO:0005125]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; receptor tyrosine kinase binding [GO:0030971]; signaling receptor binding [GO:0005102]; cytokine-mediated signaling pathway [GO:0019221]; embryonic hemopoiesis [GO:0035162]; homeostasis of number of cells within a tissue [GO:0048873]; lymphocyte differentiation [GO:0030098]; MAPK cascade [GO:0000165]; negative regulation of apoptotic process in bone marrow [GO:0071866]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of myoblast differentiation [GO:0045663]; positive regulation of myoblast fusion [GO:1901741]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myeloid dendritic cell activation [GO:0030885]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Membrane-bound; IsoId=P49771-1; Sequence=Displayed; Name=2; Synonyms=Soluble; IsoId=P49771-2; Sequence=VSP_004251, VSP_004252; Name=3; IsoId=P49771-3; Sequence=VSP_054599; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.


uniprotID: P36888
geneSymbol: FLT3
reactome: R-HSA-109704;R-HSA-449836;R-HSA-5673001;
pdb: 1RJB;3QS7;3QS9;4RT7;4XUF;5X02;
length: 993
go: ENSG00000122025;
drug: DB06080;DB05213;DB05465;DB05216;DB09079;DB08901;DB00398;DB01268;DB05014;
name:
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; integral component of plasma membrane [GO:0005887]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; cytokine receptor activity [GO:0004896]; glucocorticoid receptor binding [GO:0035259]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; protein-containing complex binding [GO:0044877]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; vascular endothelial growth factor-activated receptor activity [GO:0005021]; animal organ regeneration [GO:0031100]; B cell differentiation [GO:0030183]; cell differentiation [GO:0030154]; cellular response to cytokine stimulus [GO:0071345]; cellular response to glucocorticoid stimulus [GO:0071385]; common myeloid progenitor cell proliferation [GO:0035726]; cytokine-mediated signaling pathway [GO:0019221]; dendritic cell differentiation [GO:0097028]; hemopoiesis [GO:0030097]; leukocyte homeostasis [GO:0001776]; lymphocyte proliferation [GO:0046651]; MAPK cascade [GO:0000165]; myeloid progenitor cell differentiation [GO:0002318]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; pro-B cell differentiation [GO:0002328]; protein autophosphorylation [GO:0046777]; regulation of apoptotic process [GO:0042981]; response to organonitrogen compound [GO:0010243]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; viral process [GO:0016032]

snps:
rs12872889 rs56321896 rs146030737 rs1933437 rs35602083 rs34172843 rs56090538 rs35958982 rs121913487 rs121913488 rs121913488 rs121909646 rs121913488 rs121913232 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P36888-1; Sequence=Displayed; Name=2; IsoId=P36888-2; Sequence=VSP_041796; 

location:
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.


uniprotID: Q5VTH2
geneSymbol: CFAP126
name: Protein Flattop (Cilia- and flagella-associated protein 126)
length: 177
go: ENSG00000188931;
sequence:
MATNYSANQYEKAFSSKYLQNWSPTKPTKESISSHEGYTQIIANDRGHLLPSVPRSKANPWGSFMGTWQMPLKIPPARVTLTSRTTAGAASLTKWIQKNPDLLKASNGLCPEILGKPHDPDSQKKLRKKSITKTVQQARSPTIIPSSPAANLNSPDELQSSHPSAGHTPGPQRPAKS

opentargets:
apical plasma membrane [GO:0016324]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cilium organization [GO:0044782]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6P8X9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6P8X9}. Apical cell membrane {ECO:0000250|UniProtKB:Q6P8X9}. Note=Localizes to the apical cell membrane, the basal body and the primary cilium in monociliated node cells. {ECO:0000250|UniProtKB:Q6P8X9}.


uniprotID: Q9UPI3
geneSymbol: FLVCR2
name: Feline leukemia virus subgroup C receptor-related protein 2 (Calcium-chelate transporter) (CCT)
length: 526
go: ENSG00000119686;
snps: rs2287015 rs267606823 rs267606824 rs267606822 rs267606825 rs267606825 rs35126362
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; heme binding [GO:0020037]; heme transporter activity [GO:0015232]; heme export [GO:0097037]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UPI3-1; Sequence=Displayed; Name=2; IsoId=Q9UPI3-2; Sequence=VSP_043048, VSP_043049; Note=No experimental confirmation available.; 


uniprotID: P10768
geneSymbol: ESD
reactome: R-HSA-156590;
pdb: 3FCX;
length: 282
go: ENSG00000139684;
drug: DB00143;
snps: rs9778 rs15303
location: SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle.
name:
S-formylglutathione hydrolase (FGH) (EC 3.1.2.12) (Esterase D) (Methylumbelliferyl-acetate deacetylase) (EC 3.1.1.56)

sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; carboxylic ester hydrolase activity [GO:0052689]; hydrolase activity, acting on ester bonds [GO:0016788]; identical protein binding [GO:0042802]; methylumbelliferyl-acetate deacetylase activity [GO:0047374]; S-formylglutathione hydrolase activity [GO:0018738]; formaldehyde catabolic process [GO:0046294]; glutathione derivative biosynthetic process [GO:1901687]


uniprotID: P31513
geneSymbol: FMO3
reactome: R-HSA-217271;R-HSA-5579019;
length: 532
go: ENSG00000007933;
drug: DB00918;DB00501;DB00363;DB00250;DB01254;DB00334;DB00675;DB05294;DB00582;
name:
Dimethylaniline monooxygenase [N-oxide-forming] 3 (EC 1.14.13.8) (Dimethylaniline oxidase 3) (FMO II) (FMO form 2) (Hepatic flavin-containing monooxygenase 3) (FMO 3) (Trimethylamine monooxygenase) (EC 1.14.13.148)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; flavin adenine dinucleotide binding [GO:0050660]; monooxygenase activity [GO:0004497]; N,N-dimethylaniline monooxygenase activity [GO:0004499]; NADP binding [GO:0050661]; trimethylamine monooxygenase activity [GO:0034899]; xenobiotic metabolic process [GO:0006805]

snps:
rs72549320 rs72549321 rs72549322 rs72549323 rs12072582 rs72549326 rs2266782 rs529940450 rs28363549 rs1736557 rs2066530 rs2266780 rs28363581 rs2066532 rs72549331 rs774785217 rs72549332 rs72549334 rs72549335 

location:
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}.


uniprotID: Q9NRY5
geneSymbol: FAM114A2
reactome: R-HSA-6802952;
name: Protein FAM114A2
length: 505
go: ENSG00000055147;
opentargets: purine nucleotide binding [GO:0017076]
sequence:


uniprotID: P12104
geneSymbol: FABP2
reactome: R-HSA-163560;
pdb: 1KZW;1KZX;2MJI;2MO5;3AKM;3IFB;
length: 132
drug: DB04557;DB00783;DB01050;DB08231;DB03796;DB01138;
snps: rs1799883
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Fatty acid-binding protein, intestinal (Fatty acid-binding protein 2) (Intestinal-type fatty acid-binding protein) (I-FABP)

sequence:
MAFDSTWKVDRSENYDKFMEKMGVNIVKRKLAAHDNLKLTITQEGNKFTVKESSAFRNIEVVFELGVTFNYNLADGTELRGTWSLEGNKLIGKFKRTDNGNELNTVREIIGDELVQTYVYEGVEAKRIFKKD

opentargets:
cytosol [GO:0005829]; fatty acid binding [GO:0005504]; long-chain fatty acid binding [GO:0036041]; intestinal lipid absorption [GO:0098856]; triglyceride catabolic process [GO:0019433]


uniprotID: Q01844
geneSymbol: EWSR1
pdb: 2CPE;
name: RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpoint region 1 protein)
length: 656
go: ENSG00000182944;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=EWS; IsoId=Q01844-1; Sequence=Displayed; Name=EWS-B; IsoId=Q01844-2; Sequence=VSP_005793; Note=No experimental confirmation available.; Name=3; IsoId=Q01844-3; Sequence=VSP_043453; Name=4; IsoId=Q01844-4; Sequence=VSP_043452, VSP_043454; Note=No experimental confirmation available.; Name=5; IsoId=Q01844-5; Sequence=VSP_043451, VSP_043453; Note=No experimental confirmation available.; Name=6; IsoId=Q01844-6; Sequence=VSP_045412; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16965792}. Cytoplasm {ECO:0000269|PubMed:16965792}. Cell membrane {ECO:0000269|PubMed:16965792}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.


uniprotID: A1XBS5
geneSymbol: FAM92A
name: Protein FAM92A
length: 289
go: ENSG00000188343;
snps: rs36117362
sequence:

opentargets:
centriole [GO:0005814]; ciliary basal body [GO:0036064]; ciliary base [GO:0097546]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; cilium assembly [GO:0060271]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=FAM92A1-289 {ECO:0000303|PubMed:17646714}; IsoId=A1XBS5-1; Sequence=Displayed; Name=2; Synonyms=FAM92A1-251 {ECO:0000303|PubMed:17646714}; IsoId=A1XBS5-2; Sequence=VSP_025294; Name=3; IsoId=A1XBS5-3; Sequence=VSP_025296; Name=4; IsoId=A1XBS5-4; Sequence=VSP_025295; Note=No experimental confirmation available.; Name=5; IsoId=A1XBS5-5; Sequence=VSP_025292, VSP_025293; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27528616}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:27528616}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27528616}. Note=Weak punctate vesicular distribution throughout the cytoplasm (PubMed:27528616). Localizes at the distal end of mother centrioles (PubMed:27528616). Extensive colocalization with CBY1 at mother centrioles (PubMed:27528616). {ECO:0000269|PubMed:27528616}.; SUBCELLULAR LOCATION: Isoform 3: Nucleus {ECO:0000269|PubMed:17646714}.


uniprotID: Q13158
geneSymbol: FADD
pdb: 1A1W;1A1Z;1E3Y;1E41;2GF5;3EZQ;3OQ9;
length: 208
go: ENSG00000168040;
snps: rs387906839
reactome:
R-HSA-140534;R-HSA-2562578;R-HSA-3371378;R-HSA-5213460;R-HSA-5218900;R-HSA-5357786;R-HSA-69416;R-HSA-75157;R-HSA-75158;R-HSA-9013957;R-HSA-933543;

name:
FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) (Protein FADD)

sequence:

opentargets:
CD95 death-inducing signaling complex [GO:0031265]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; membrane raft [GO:0045121]; neuron projection [GO:0043005]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ripoptosome [GO:0097342]; caspase binding [GO:0089720]; death effector domain binding [GO:0035877]; death receptor binding [GO:0005123]; identical protein binding [GO:0042802]; protease binding [GO:0002020]; protein-containing complex binding [GO:0044877]; receptor serine/threonine kinase binding [GO:0033612]; tumor necrosis factor receptor binding [GO:0005164]; tumor necrosis factor receptor superfamily binding [GO:0032813]; activation of cysteine-type endopeptidase activity [GO:0097202]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; behavioral response to cocaine [GO:0048148]; cell surface receptor signaling pathway [GO:0007166]; cellular response to mechanical stimulus [GO:0071260]; death-inducing signaling complex assembly [GO:0071550]; defense response to virus [GO:0051607]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway in absence of ligand [GO:0097192]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; innate immune response [GO:0045087]; lymph node development [GO:0048535]; motor neuron apoptotic process [GO:0097049]; necroptotic signaling pathway [GO:0097527]; negative regulation of activation-induced cell death of T cells [GO:0070236]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of necroptotic process [GO:0060546]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of adaptive immune response [GO:0002821]; positive regulation of apoptotic process [GO:0043065]; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation [GO:2000454]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of macrophage differentiation [GO:0045651]; positive regulation of proteolysis [GO:0045862]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; response to morphine [GO:0043278]; spleen development [GO:0048536]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; thymus development [GO:0048538]; toll-like receptor 3 signaling pathway [GO:0034138]; TRAIL-activated apoptotic signaling pathway [GO:0036462]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; viral process [GO:0016032]


uniprotID: Q8IZT9
geneSymbol: FAM9C
name: Protein FAM9C
length: 166
go: ENSG00000187268;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12213195}.
sequence:
MAAKDQLEVQVMAAQEMELAGKDPVSHEHEERKPVTETKEGDVTDEHGERGSFAETDEHTGVDTKELEDIAADIKEHLAAKRKRIEKIAKACSEIKNRIKNVLRTTQLKRQKRDYRISLKLPNVLEEFITDEQKDEEGDGEKEEQIKIFQEQQKRWQQDGKGTERD

opentargets:
synaptonemal complex [GO:0000795]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]


uniprotID: Q9BX63
geneSymbol: BRIP1
pdb: 1T15;1T29;3AL3;
length: 1249
go: ENSG00000136492;
reactome:
R-HSA-2564830;R-HSA-5685938;R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;

name:
Fanconi anemia group J protein (Protein FACJ) (EC 3.6.4.13) (ATP-dependent RNA helicase BRIP1) (BRCA1-associated C-terminal helicase 1) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 4 iron, 4 sulfur cluster binding [GO:0051539]; ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; cellular response to angiotensin [GO:1904385]; cellular response to hypoxia [GO:0071456]; cellular response to vitamin [GO:0071295]; chiasma assembly [GO:0051026]; DNA damage checkpoint [GO:0000077]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair involved in meiotic recombination [GO:1990918]; meiotic DNA double-strand break processing involved in reciprocal meiotic recombination [GO:0010705]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; nucleotide-excision repair [GO:0006289]; regulation of transcription by RNA polymerase II [GO:0006357]; response to toxic substance [GO:0009636]; seminiferous tubule development [GO:0072520]; spermatid development [GO:0007286]; spermatogonial cell division [GO:0007284]

snps:
rs28903098 rs4988345 rs4988346 rs4988347 rs28997569 rs4988350 rs4988349 rs28997572 rs4988355 rs4986764 rs4988356 rs28997573 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BX63-1; Sequence=Displayed; Name=2; IsoId=Q9BX63-2; Sequence=VSP_012540, VSP_012541; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:23585563}. Cytoplasm {ECO:0000269|PubMed:23585563}.


uniprotID: O94887
geneSymbol: FARP2
reactome: R-HSA-399955;
length: 1054
go: ENSG00000006607;
snps: rs16843643 rs757978 rs41342147
name:
FERM, ARHGEF and pleckstrin domain-containing protein 2 (FERM domain-including RhoGEF) (FIR) (FERM, RhoGEF and pleckstrin domain-containing protein 2) (Pleckstrin homology domain-containing family C member 3) (PH domain-containing family C member 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; cytoskeletal protein binding [GO:0008092]; Rac guanyl-nucleotide exchange factor activity [GO:0030676]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; actin cytoskeleton reorganization [GO:0031532]; cell adhesion [GO:0007155]; hair cycle process [GO:0022405]; neuron remodeling [GO:0016322]; osteoclast differentiation [GO:0030316]; podosome assembly [GO:0071800]; Rac protein signal transduction [GO:0016601]; regulation of integrin activation [GO:0033623]; regulation of Rho protein signal transduction [GO:0035023]; semaphorin-plexin signaling pathway [GO:0071526]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O94887-1; Sequence=Displayed; Name=2; IsoId=O94887-2; Sequence=VSP_017977, VSP_017978; Name=3; IsoId=O94887-3; Sequence=VSP_054840, VSP_054841; Note=No experimental confirmation available.; 


uniprotID: Q53R41
geneSymbol: FASTKD1
name: FAST kinase domain-containing protein 1, mitochondrial
length: 847
go: ENSG00000138399;
snps: rs12618227 rs35106223 rs2253680
sequence:

opentargets:
mitochondrion [GO:0005739]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; cellular respiration [GO:0045333]; mitochondrial RNA metabolic process [GO:0000959]; regulation of mitochondrial mRNA stability [GO:0044528]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q53R41-1; Sequence=Displayed; Name=2; IsoId=Q53R41-2; Sequence=VSP_024617; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:28335001}. Note=Preferentially localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:28335001). {ECO:0000269|PubMed:28335001}.


uniprotID: Q969Z0
geneSymbol: TBRG4
length: 631
go: ENSG00000136270;
snps: rs2304694 rs2304693
name:
FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; cell cycle arrest [GO:0007050]; cellular respiration [GO:0045333]; mitochondrial mRNA processing [GO:0090615]; mRNA metabolic process [GO:0016071]; positive regulation of cell proliferation [GO:0008284]; regulation of mitochondrial mRNA stability [GO:0044528]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969Z0-1; Sequence=Displayed; Name=2; IsoId=Q969Z0-2; Sequence=VSP_022460; 

location:
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:28335001}.


uniprotID: Q9UBX5
geneSymbol: FBLN5
reactome: R-HSA-1566948;R-HSA-2129379;
length: 448
go: ENSG00000140092;
name:
Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; integrin binding [GO:0005178]; protein C-terminus binding [GO:0008022]; protein homodimerization activity [GO:0042803]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; extracellular matrix organization [GO:0030198]; protein localization to cell surface [GO:0034394]; regulation of cell growth [GO:0001558]; regulation of removal of superoxide radicals [GO:2000121]; secretion [GO:0046903]

snps:
rs141200859 rs121434299 rs121434300 rs121434301 rs144288844 rs61734479 rs28939072 rs80338765 rs80338766 rs28939370 rs149396611 rs377360782 rs28939073 rs121434302 rs1802492 rs864309526 rs121434303 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16652333, ECO:0000269|PubMed:17035250, ECO:0000269|PubMed:20599547}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17035250}. Note=co-localizes with ELN in elastic fibers. {ECO:0000269|PubMed:17035250}.


uniprotID: Q8NI29
geneSymbol: FBXO27
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 27 (F-box/G-domain protein 5)
length: 283
go: ENSG00000161243;
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]


uniprotID: Q9UK22
geneSymbol: FBXO2
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 2
length: 296
go: ENSG00000116661;
snps: rs9614
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum [GO:0005783]; organelle membrane [GO:0031090]; SCF ubiquitin ligase complex [GO:0019005]; amyloid-beta binding [GO:0001540]; carbohydrate binding [GO:0030246]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein modification process [GO:0006464]; glycoprotein catabolic process [GO:0006516]; negative regulation of cell proliferation [GO:0008285]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of protein ubiquitination [GO:0031396]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q5XUX0
geneSymbol: FBXO31
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 5VZT;5VZU;
name: F-box only protein 31
length: 539
go: ENSG00000103264;
sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; SCF ubiquitin ligase complex [GO:0019005]; cyclin binding [GO:0030332]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular response to DNA damage stimulus [GO:0006974]; mitotic G1 DNA damage checkpoint [GO:0031571]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of neuron migration [GO:2001224]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5XUX0-1; Sequence=Displayed; Name=2; IsoId=Q5XUX0-2; Sequence=VSP_037469; Note=No experimental confirmation available.; 


uniprotID: Q96P31
geneSymbol: FCRL3
length: 734
go: ENSG00000160856;
snps: rs7522061 rs12041673 rs944627 rs2282284
name:
Fc receptor-like protein 3 (FcR-like protein 3) (FcRL3) (Fc receptor homolog 3) (FcRH3) (IFGP family protein 3) (hIFGP3) (Immune receptor translocation-associated protein 3) (SH2 domain-containing phosphatase anchor protein 2) (CD antigen CD307c)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; kinase binding [GO:0019900]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase binding [GO:1990782]; negative regulation of B cell receptor signaling pathway [GO:0050859]; negative regulation of immunoglobulin production [GO:0002638]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein serine/threonine phosphatase activity [GO:1905184]; regulation of B cell activation [GO:0050864]; regulation of B cell differentiation [GO:0045577]; regulation of calcium ion import [GO:0090279]; regulation of toll-like receptor 9 signaling pathway [GO:0034163]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=Spap2a; IsoId=Q96P31-1; Sequence=Displayed; Name=2; Synonyms=Spap2b; IsoId=Q96P31-2; Sequence=VSP_033300; Name=3; Synonyms=Spap2c; IsoId=Q96P31-3; Sequence=VSP_033305; Name=4; Synonyms=Spap2d; IsoId=Q96P31-4; Sequence=VSP_033301, VSP_033303; Name=5; IsoId=Q96P31-5; Sequence=VSP_033302, VSP_033304; Name=6; IsoId=Q96P31-6; Sequence=VSP_033308; Note=No experimental confirmation available.; Name=7; IsoId=Q96P31-7; Sequence=VSP_033306, VSP_033307; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395, ECO:0000269|PubMed:20190142}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.


uniprotID: Q96PJ5
geneSymbol: FCRL4
length: 515
go: ENSG00000163518;
snps: rs11582663 rs4561035 rs2039401 rs3811028
name:
Fc receptor-like protein 4 (FcR-like protein 4) (FcRL4) (Fc receptor homolog 4) (FcRH4) (IFGP family protein 2) (hIFGP2) (Immune receptor translocation-associated protein 1) (CD antigen CD307d)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96PJ5-1; Sequence=Displayed; Name=2; IsoId=Q96PJ5-2; Sequence=VSP_033310; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16157685, ECO:0000269|PubMed:16849395}.


uniprotID: Q9Y3I1
geneSymbol: FBXO7
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 4L9C;4L9H;
name: F-box only protein 7
length: 522
go: ENSG00000100225;
snps: rs11107 rs71799110 rs148272407
sequence:

opentargets:
classical Lewy body [GO:0097414]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; glial cytoplasmic inclusion [GO:0097409]; Lewy body core [GO:1990037]; Lewy body corona [GO:1990038]; Lewy neurite [GO:0097462]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; protein heterodimerization activity [GO:0046982]; protein kinase binding [GO:0019901]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; autophagy of mitochondrion [GO:0000422]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of hydrogen peroxide-induced neuron death [GO:1903208]; negative regulation of lymphocyte differentiation [GO:0045620]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; positive regulation of autophagy of mitochondrion [GO:1903599]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein targeting to mitochondrion [GO:0006626]; protein ubiquitination [GO:0016567]; regulation of locomotion [GO:0040012]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y3I1-1; Sequence=Displayed; Name=2; IsoId=Q9Y3I1-2; Sequence=VSP_041073, VSP_041074; Name=3; IsoId=Q9Y3I1-3; Sequence=VSP_044723; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria.


uniprotID: P98095
geneSymbol: FBLN2
reactome: R-HSA-2129379;
name: Fibulin-2 (FIBL-2)
length: 1184
go: ENSG00000163520;
snps: rs60850813 rs28587534 rs3732666 rs3796318 rs9843344 rs1061375
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; calcium ion binding [GO:0005509]; extracellular matrix binding [GO:0050840]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix organization [GO:0030198]; positive regulation of cell-substrate adhesion [GO:0010811]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P98095-1; Sequence=Displayed; Name=2; IsoId=P98095-2; Sequence=VSP_041404; 


uniprotID: P0C2W1
geneSymbol: FBXO45
name: F-box/SPRY domain-containing protein 1 (F-box only protein 45) (hFbxo45)
length: 286
go: ENSG00000174013;
sequence:

opentargets:
cell junction [GO:0030054]; glutamatergic synapse [GO:0098978]; postsynaptic cytosol [GO:0099524]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; presynaptic cytosol [GO:0099523]; presynaptic membrane [GO:0042734]; SCF ubiquitin ligase complex [GO:0019005]; synapse [GO:0045202]; ubiquitin-protein transferase activity [GO:0004842]; anterior commissure morphogenesis [GO:0021960]; cellular response to DNA damage stimulus [GO:0006974]; cerebral cortex radially oriented cell migration [GO:0021799]; cerebral cortex tangential migration [GO:0021800]; corticospinal tract morphogenesis [GO:0021957]; neuron migration [GO:0001764]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; synapse assembly involved in innervation [GO:0060386]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.


uniprotID: Q9UKB1
geneSymbol: FBXW11
length: 542
go: ENSG00000072803;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
reactome:
R-HSA-1169091;R-HSA-202424;R-HSA-2565942;R-HSA-2871837;R-HSA-5607761;R-HSA-5607764;R-HSA-5676590;R-HSA-5684264;R-HSA-8951664;R-HSA-983168;

name:
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)

sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; protein dimerization activity [GO:0046983]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; G2/M transition of mitotic cell cycle [GO:0000086]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of transcription, DNA-templated [GO:0045892]; NIK/NF-kappaB signaling [GO:0038061]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of proteolysis [GO:0045862]; positive regulation of transcription, DNA-templated [GO:0045893]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein dephosphorylation [GO:0006470]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; stress-activated MAPK cascade [GO:0051403]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=C; IsoId=Q9UKB1-1; Sequence=Displayed; Name=A; IsoId=Q9UKB1-2; Sequence=VSP_006765; Name=B; IsoId=Q9UKB1-3; Sequence=VSP_006766; 


uniprotID: O95967
geneSymbol: EFEMP2
reactome: R-HSA-2129379;
pdb: 2KL7;
name: EGF-containing fibulin-like extracellular matrix protein 2 (Fibulin-4) (FIBL-4) (Protein UPH1)
length: 443
go: ENSG00000172638;
snps: rs119489101 rs601314 rs193302866 rs119489102
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
basement membrane [GO:0005604]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; elastic fiber assembly [GO:0048251]


uniprotID: Q8N531
geneSymbol: FBXL6
name: F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6) (FBL6A)
length: 539
sequence:

opentargets:
SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; proteolysis [GO:0006508]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N531-1; Sequence=Displayed; Name=2; IsoId=Q8N531-2; Sequence=VSP_008498; 


uniprotID: Q14192
geneSymbol: FHL2
reactome: R-HSA-1989781;
pdb: 1X4K;1X4L;2D8Z;2MIU;
length: 279
go: ENSG00000115641;
name:
Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)

sequence:

opentargets:
focal adhesion [GO:0005925]; M band [GO:0031430]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Z disc [GO:0030018]; androgen receptor binding [GO:0050681]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; androgen receptor signaling pathway [GO:0030521]; atrial cardiac muscle cell development [GO:0055014]; heart trabecula formation [GO:0060347]; negative regulation of apoptotic process [GO:0043066]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of lipid metabolic process [GO:0019216]; response to hormone [GO:0009725]; ventricular cardiac muscle cell development [GO:0055015]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14192-1; Sequence=Displayed; Name=2; IsoId=Q14192-2; Sequence=VSP_056999, VSP_057000; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O35115}.


uniprotID: Q96A26
geneSymbol: FAM162A
name: Protein FAM162A (E2-induced gene 5 protein) (Growth and transformation-dependent protein) (HGTD-P)
length: 154
go: ENSG00000114023;
snps: rs17850692
sequence:
MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; mitochondrion [GO:0005739]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; cellular response to hypoxia [GO:0071456]; neuron apoptotic process [GO:0051402]; positive regulation of apoptotic process [GO:0043065]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:15082785, ECO:0000269|PubMed:16698020}.


uniprotID: Q9NSI2
geneSymbol: FAM207A
name: Protein FAM207A
length: 230
go: ENSG00000160256;
snps: rs3737075
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=A; IsoId=Q9NSI2-1; Sequence=Displayed; Name=B; IsoId=Q9NSI2-2; Sequence=VSP_003831; 


uniprotID: F5H4B4
geneSymbol: FAM227A
name: Protein FAM227A
length: 570
go: ENSG00000184949;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=F5H4B4-1; Sequence=Displayed; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=2; IsoId=F5H4B4-2; Sequence=VSP_044139, VSP_044140; 


uniprotID: Q96KR6
geneSymbol: FAM210B
name: Protein FAM210B, mitochondrial
length: 192
go: ENSG00000124098;
snps: rs6099115
sequence:
MAGLLALLGPAGRVGARVRPRATWLLGATAPCAPPPLALALLPPRLDARLLRTARGDCRGHQDPSQATGTTGSSVSCTEEKKQSKSQQLKKIFQEYGTVGVSLHIGISLISLGIFYMVVSSGVDMPAILLKLGFKESLVQSKMAAGTSTFVVAYAIHKLFAPVRISITLVSVPLIVRYFRKVGFFKPPAAKP

opentargets:
integral component of membrane [GO:0016021]; intrinsic component of membrane [GO:0031224]; mitochondrial outer membrane [GO:0005741]; cellular response to estradiol stimulus [GO:0071392]; erythrocyte maturation [GO:0043249]; positive regulation of erythrocyte differentiation [GO:0045648]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26968549}. Mitochondrion outer membrane {ECO:0000269|PubMed:28594398}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q32MH5
geneSymbol: FAM214A
name: Protein FAM214A
length: 1076
go: ENSG00000047346;
snps: rs8036680 rs12915981
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q32MH5-1; Sequence=Displayed; Name=2; IsoId=Q32MH5-2; Sequence=VSP_030580, VSP_030581; Name=3; IsoId=Q32MH5-3; Sequence=VSP_042435; Note=No experimental confirmation available.; 


uniprotID: A1KXE4
geneSymbol: FAM168B
name: Myelin-associated neurite-outgrowth inhibitor (Mani) (p20)
length: 195
go: ENSG00000152102;
sequence:
MNPVYSPGSSGVPYANAKGIGYPAGFPMGYAAAAPAYSPNMYPGANPTFQTGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQQGTYYTQPLYAAPPHVIHHTTVVQPNGMPATVYPAPIPPPRGNGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW

opentargets:
axon [GO:0030424]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A1KXE4-1; Sequence=Displayed; Name=2; IsoId=A1KXE4-2; Sequence=VSP_032508; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane {ECO:0000250|UniProtKB:Q80XQ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80XQ8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80XQ8}. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250|UniProtKB:Q80XQ8}.


uniprotID: A6NDY2
geneSymbol: FAM90A10P
name: Putative protein FAM90A10P
length: 464
sequence:


uniprotID: Q8IYT1
geneSymbol: FAM71A
name: Protein FAM71A
length: 594
go: ENSG00000162771;
opentargets: nucleus [GO:0005634]
snps: rs17853363 rs3122712 rs17853362 rs3122713 rs3795842
sequence:


uniprotID: O94988
geneSymbol: FAM13A
reactome: R-HSA-194840;
name: Protein FAM13A
length: 1023
go: ENSG00000138640;
snps: rs7657817
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=3; Synonyms=FAM13A1_v2; IsoId=O94988-4; Sequence=Displayed; Name=1; Synonyms=FAM13A1_v1; IsoId=O94988-1; Sequence=VSP_039154, VSP_039155; Name=2; IsoId=O94988-3; Sequence=VSP_039154, VSP_039155, VSP_039158; Note=No experimental confirmation available.; Name=4; IsoId=O94988-5; Sequence=VSP_039153, VSP_039156; Note=No experimental confirmation available.; Name=5; IsoId=O94988-6; Sequence=VSP_039152, VSP_039157; Note=No experimental confirmation available.; 


uniprotID: Q9UI08
geneSymbol: EVL
reactome: R-HSA-202433;R-HSA-376176;R-HSA-5663220;
name: Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)
length: 416
go: ENSG00000196405;
snps: rs367737727
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; membrane [GO:0016020]; phagocytic vesicle [GO:0045335]; actin binding [GO:0003779]; profilin binding [GO:0005522]; SH3 domain binding [GO:0017124]; actin filament organization [GO:0007015]; actin nucleation [GO:0045010]; actin polymerization or depolymerization [GO:0008154]; animal organ morphogenesis [GO:0009887]; axon guidance [GO:0007411]; cell surface receptor signaling pathway [GO:0007166]; cellular response to interferon-gamma [GO:0071346]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of ruffle assembly [GO:1900028]; nervous system development [GO:0007399]; positive regulation of stress fiber assembly [GO:0051496]; protein homotetramerization [GO:0051289]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=2; Synonyms=EVL-I; IsoId=Q9UI08-1; Sequence=Displayed; Name=1; IsoId=Q9UI08-2; Sequence=VSP_004044; Name=3; IsoId=Q9UI08-3; Sequence=VSP_057322, VSP_057323; Note=No experimental confirmation available.; Name=4; IsoId=Q9UI08-4; Sequence=VSP_058779; Name=5; IsoId=Q9UI08-5; Sequence=VSP_004044, VSP_058778; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P70429}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:P70429}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P70429}. Note=Targeted to the leading edge of lamellipodia and the distal tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes. {ECO:0000250|UniProtKB:P70429}.


uniprotID: Q9NUQ9
geneSymbol: FAM49B
reactome: R-HSA-114608;
name: Protein FAM49B (L1)
length: 324
go: ENSG00000153310;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.
sequence:

opentargets:
cilium [GO:0005929]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; MHC class Ib protein binding, via antigen binding groove [GO:0023030]; platelet degranulation [GO:0002576]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of memory T cell activation [GO:2000568]; positive regulation of T cell activation [GO:0050870]; positive regulation of T cell mediated cytotoxicity [GO:0001916]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NUQ9-1; Sequence=Displayed; Name=2; IsoId=Q9NUQ9-2; Sequence=VSP_056503; Note=No experimental confirmation available.; 


uniprotID: P0C7U9
geneSymbol: FAM87A
name: Protein FAM87A
length: 286
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9Y2M0
geneSymbol: FAN1
reactome: R-HSA-6783310;
pdb: 4REA;4REB;4REC;4RI8;4RI9;4RIA;4RIB;4RIC;4RID;4RY3;
length: 1017
go: ENSG00000198690;
snps: rs4779794 rs1270571213 rs751703979
name:
Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)

sequence:

opentargets:
cytosol [GO:0005829]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; flap-structured DNA binding [GO:0070336]; magnesium ion binding [GO:0000287]; phosphodiesterase I activity [GO:0004528]; ubiquitin-dependent protein binding [GO:0140036]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; interstrand cross-link repair [GO:0036297]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA incision [GO:0033683]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2M0-1; Sequence=Displayed; Name=2; IsoId=Q9Y2M0-2; Sequence=VSP_029429, VSP_029430; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:20671156, ECO:0000269|PubMed:20935496}. Note=Localizes at sites of DNA damage following recruitment by monoubiquitinated FANCD2 (PubMed:20603015, PubMed:20603016). Localizes to stalled replication forks via its UBZ-type zinc finger (PubMed:20935496). {ECO:0000269|PubMed:20603015, ECO:0000269|PubMed:20603016, ECO:0000269|PubMed:20935496}.


uniprotID: Q6P2I3
geneSymbol: FAHD2B
name: Fumarylacetoacetate hydrolase domain-containing protein 2B (EC 3.-.-.-)
length: 314
go: ENSG00000144199;
opentargets: hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]
sequence:


uniprotID: Q9NW38
geneSymbol: FANCL
reactome: R-HSA-6783310;
pdb: 3ZQS;4CCG;
length: 375
go: ENSG00000115392;
snps: rs36059257
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
name:
E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL)

sequence:

opentargets:
cytoplasm [GO:0005737]; Fanconi anaemia nuclear complex [GO:0043240]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; gamete generation [GO:0007276]; interstrand cross-link repair [GO:0036297]; protein monoubiquitination [GO:0006513]; regulation of cell proliferation [GO:0042127]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NW38-1; Sequence=Displayed; Name=2; IsoId=Q9NW38-2; Sequence=VSP_041727; 


uniprotID: Q8TC84
geneSymbol: FANK1
name: Fibronectin type 3 and ankyrin repeat domains protein 1
length: 345
go: ENSG00000203780;
snps: rs17153879 rs17153882 rs1666 rs17153976
sequence:

opentargets:
ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TC84-1; Sequence=Displayed; Name=2; IsoId=Q8TC84-2; Sequence=VSP_013568; Name=3; IsoId=Q8TC84-3; Sequence=VSP_013569; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:27060496}. Cytoplasm, cytosol {ECO:0000269|PubMed:20978819}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9DAM9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9DAM9}.


uniprotID: Q9HBA9
geneSymbol: FOLH1B
reactome: R-HSA-70614;
length: 442
snps: rs10830339
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:14716746}.
name:
Putative N-acetylated-alpha-linked acidic dipeptidase (NAALADase) (EC 3.4.-.-) (Cell growth-inhibiting gene 26 protein) (Prostate-specific membrane antigen-like protein) (Putative folate hydrolase 1B)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; dipeptidase activity [GO:0016805]; metal ion binding [GO:0046872]; metallocarboxypeptidase activity [GO:0004181]; C-terminal protein deglutamylation [GO:0035609]; cellular amino acid biosynthetic process [GO:0008652]


uniprotID: Q5FWF7
geneSymbol: FBXO48
name: F-box only protein 48
length: 155
go: ENSG00000204923;
snps: rs12614904
sequence:
MHKNSKRNNNLRVSHTEANSVDAEKEKNESQNNFFELLPAEITFKIFSQLDIRSLCRASLTCRSWNDTIRNSDSLWKPHCMTVRAVCRREIDDDLESGYSWRVILLRNYQKSKVKHEWLSGRYSNICSPISLPEKIMYPMDADTWGEILEAELER

opentargets:
cytoplasm [GO:0005737]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]


uniprotID: Q9UKT8
geneSymbol: FBXW2
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
name: F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
length: 454
go: ENSG00000119402;
sequence:

opentargets:
cytosol [GO:0005829]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein modification process [GO:0006464]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UKT8-1; Sequence=Displayed; Name=2; Synonyms=MD6b; IsoId=Q9UKT8-2; Sequence=VSP_012983; 


uniprotID: Q9UKT4
geneSymbol: FBXO5
reactome: R-HSA-174113;R-HSA-176408;R-HSA-176417;R-HSA-539107;R-HSA-68881;
pdb: 2M6N;4UI9;
name: F-box only protein 5 (Early mitotic inhibitor 1)
length: 447
go: ENSG00000112029;
snps: rs2073260 rs7763565
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; anaphase-promoting complex binding [GO:0010997]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; ubiquitin ligase inhibitor activity [GO:1990948]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; microtubule polymerization [GO:0046785]; negative regulation of cellular senescence [GO:2000773]; negative regulation of DNA endoreduplication [GO:0032876]; negative regulation of meiotic nuclear division [GO:0045835]; negative regulation of mitotic metaphase/anaphase transition [GO:0045841]; negative regulation of response to DNA damage stimulus [GO:2001021]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-protein transferase activity [GO:0051444]; oocyte maturation [GO:0001556]; positive regulation of biomineral tissue development [GO:0070169]; positive regulation of cell proliferation [GO:0008284]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of mesenchymal stem cell migration [GO:1905322]; positive regulation of osteoblast differentiation [GO:0045669]; protein ubiquitination [GO:0016567]; regulation of DNA replication [GO:0006275]; regulation of mitotic cell cycle [GO:0007346]; regulation of transcription involved in G1/S transition of mitotic cell cycle [GO:0000083]; spindle assembly involved in female meiosis I [GO:0007057]; vesicle organization [GO:0016050]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UKT4-1; Sequence=Displayed; Name=2; IsoId=Q9UKT4-2; Sequence=VSP_041362; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11988738}. Cytoplasm {ECO:0000269|PubMed:11988738}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15469984}. Note=In interphase, localizes in a punctate manner in the nucleus and cytoplasm with some perinuclear concentration (PubMed:11988738). In mitotic cells, localizes throughout the cell, particularly at the spindle (PubMed:15469984). {ECO:0000269|PubMed:11988738, ECO:0000269|PubMed:15469984}.


uniprotID: Q05932
geneSymbol: FPGS
reactome: R-HSA-196757;
length: 587
go: ENSG00000136877;
drug: DB00142;DB00563;DB06813;DB00293;
snps: rs1034635821 rs759336102 rs10760502 rs12686275 rs35789560 rs17855900 rs200314440 rs34354111
name:
Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; tetrahydrofolylpolyglutamate synthase activity [GO:0004326]; animal organ regeneration [GO:0031100]; brain development [GO:0007420]; cell proliferation [GO:0008283]; folic acid metabolic process [GO:0046655]; folic acid-containing compound metabolic process [GO:0006760]; glutamate metabolic process [GO:0006536]; liver development [GO:0001889]; nucleobase-containing compound metabolic process [GO:0006139]; one-carbon metabolic process [GO:0006730]; tetrahydrofolylpolyglutamate biosynthetic process [GO:0046901]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=4;  Name=1; Synonyms=Mitochondrial; IsoId=Q05932-1; Sequence=Displayed; Name=2; Synonyms=Cytoplasmic; IsoId=Q05932-2; Sequence=VSP_018733; Note=Produced by alternative initiation at Met-43 of isoform 1.; Name=3; IsoId=Q05932-3; Sequence=VSP_018733, VSP_041959; Note=Produced by alternative splicing of isoform 1.; Name=4; IsoId=Q05932-4; Sequence=VSP_041960; Note=Produced by alternative splicing of isoform 1.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Mitochondrion inner membrane {ECO:0000269|PubMed:16169100}. Mitochondrion matrix {ECO:0000269|PubMed:16169100, ECO:0000269|PubMed:8408020, ECO:0000269|PubMed:8662720}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:8662720}.


uniprotID: Q13630
geneSymbol: TSTA3
reactome: R-HSA-6787639;
pdb: 4B8W;4B8Z;4BKP;4BL5;4E5Y;
length: 321
go: ENSG00000104522;
drug: DB00157;
name:
GDP-L-fucose synthase (EC 1.1.1.271) (GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase) (Protein FX) (Red cell NADP(H)-binding protein) (Short-chain dehydrogenase/reductase family 4E member 1)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; coenzyme binding [GO:0050662]; electron transfer activity [GO:0009055]; GDP-4-dehydro-D-rhamnose reductase activity [GO:0042356]; GDP-L-fucose synthase activity [GO:0050577]; GDP-mannose 3,5-epimerase activity [GO:0047918]; identical protein binding [GO:0042802]; isomerase activity [GO:0016853]; 'de novo' GDP-L-fucose biosynthetic process [GO:0042351]; GDP-mannose metabolic process [GO:0019673]; leukocyte cell-cell adhesion [GO:0007159]; T cell mediated cytotoxicity [GO:0001913]


uniprotID: P31995
geneSymbol: FCGR2C
pdb: 3WJL;
length: 323
name:
Low affinity immunoglobulin gamma Fc region receptor II-c (IgG Fc receptor II-c) (CDw32) (Fc-gamma RII-c) (Fc-gamma-RIIc) (FcRII-c) (CD antigen CD32)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; IgG binding [GO:0019864]; transmembrane signaling receptor activity [GO:0004888]; immune response [GO:0006955]

drug:
DB00054;DB00051;DB00092;DB00087;DB00074;DB00112;DB00002;DB00111;DB00095;DB00005;DB00056;DB00078;DB00028;DB00075;DB00108;DB00110;DB00073;DB00081;DB00072;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=IIC1; Synonyms=C1; IsoId=P31995-1; Sequence=Displayed; Name=IIC2; IsoId=P31995-2; Sequence=VSP_002646; Name=IIC3; IsoId=P31995-3; Sequence=VSP_002645; Name=IIC4; IsoId=P31995-4; Sequence=VSP_002644; 

location:
SUBCELLULAR LOCATION: Isoform IIC4: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform IIC3: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform IIC2: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform IIC1: Cell membrane; Single-pass type I membrane protein.


uniprotID: Q9Y6R7
geneSymbol: FCGBP
name: IgGFc-binding protein (Fcgamma-binding protein antigen) (FcgammaBP)
length: 5405
opentargets: extracellular exosome [GO:0070062]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

snps:
rs34181317 rs34939346 rs35338934 rs35922811 rs34254649 rs11083543 rs36106401 rs2909229 rs34938990 rs7248839 rs7249743 rs885723 rs140171218 rs2542319 rs2542316 rs3746009 rs6508919 rs2542318 rs3746009 rs1975181 rs6508919 rs3746013 rs741143 


uniprotID: Q9UKA1
geneSymbol: FBXL5
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-917937;R-HSA-983168;
pdb: 3U9J;3U9M;3V5X;3V5Y;3V5Z;
length: 691
go: ENSG00000118564;
location: SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17532294}.
name:
F-box/LRR-repeat protein 5 (F-box and leucine-rich repeat protein 5) (F-box protein FBL4/FBL5) (p45SKP2-like protein)

sequence:

opentargets:
cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; iron ion binding [GO:0005506]; ubiquitin-protein transferase activity [GO:0004842]; cellular iron ion homeostasis [GO:0006879]; iron ion homeostasis [GO:0055072]; positive regulation of cellular protein catabolic process [GO:1903364]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UKA1-1; Sequence=Displayed; Name=2; IsoId=Q9UKA1-2; Sequence=VSP_008417; Note=No experimental confirmation available.; 


uniprotID: Q8WWV6
geneSymbol: FCAMR
reactome: R-HSA-202733;
length: 532
name:
High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fc alpha/mu receptor) (CD antigen CD351)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; adaptive immune response [GO:0002250]; leukocyte migration [GO:0050900]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8WWV6-1; Sequence=Displayed; Name=2; IsoId=Q8WWV6-2; Sequence=VSP_033228, VSP_033229; Note=No experimental confirmation available.; Name=3; IsoId=Q8WWV6-3; Sequence=VSP_033227, VSP_033230, VSP_033232; Note=No experimental confirmation available.; Name=4; IsoId=Q8WWV6-4; Sequence=VSP_033231; 


uniprotID: Q9BPY3
geneSymbol: FAM118B
name: Protein FAM118B
length: 351
go: ENSG00000197798;
opentargets: Cajal body [GO:0015030]; Cajal body organization [GO:0030576]
location: SUBCELLULAR LOCATION: Nucleus, Cajal body {ECO:0000269|PubMed:24569877}.
sequence:


uniprotID: Q17RC7
geneSymbol: EXOC3L4
name: Exocyst complex component 3-like protein 4
length: 722
go: ENSG00000205436;
snps: rs2297067 rs2297066 rs10131298 rs729184 rs744153
sequence:

opentargets:
exocyst [GO:0000145]; SNARE binding [GO:0000149]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]


uniprotID: A4D161
geneSymbol: FAM221A
name: Protein FAM221A
length: 298
go: ENSG00000188732;
snps: rs17855785 rs34518648 rs35495590 rs17855786 rs35928055
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A4D161-1; Sequence=Displayed; Name=2; IsoId=A4D161-2; Sequence=VSP_026739; Name=3; IsoId=A4D161-3; Sequence=VSP_026738, VSP_026739; 


uniprotID: Q9NPD3
geneSymbol: EXOSC4
reactome: R-HSA-380994;R-HSA-429958;R-HSA-450385;R-HSA-450513;R-HSA-450604;R-HSA-6791226;
pdb: 2NN6;6D6Q;6D6R;6H25;
name: Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)
length: 245
go: ENSG00000178896;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; intermediate filament cytoskeleton [GO:0045111]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]; 3'-5'-exoribonuclease activity [GO:0000175]; AU-rich element binding [GO:0017091]; defense response to virus [GO:0051607]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of cell growth [GO:0030307]; regulation of mRNA stability [GO:0043488]; rRNA catabolic process [GO:0016075]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:17545563}. Nucleus {ECO:0000269|PubMed:17545563}.


uniprotID: Q9Y421
geneSymbol: FAM32A
name: Protein FAM32A (Ovarian tumor-associated gene 12) (OTAG-12)
length: 112
go: ENSG00000105058;
location: SUBCELLULAR LOCATION: Isoform 1: Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Nucleus.
sequence:
MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKLLEAMGTSKKNEEEKRRGLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=OTAG-12b; IsoId=Q9Y421-1; Sequence=Displayed; Name=2; Synonyms=OTAG-12a; IsoId=Q9Y421-2; Sequence=VSP_043861; Name=3; Synonyms=OTAG-12c; IsoId=Q9Y421-3; Sequence=VSP_043860; 


uniprotID: Q86YD7
geneSymbol: FAM90A1
name: Protein FAM90A1
length: 464
go: ENSG00000171847;
snps: rs9738115 rs9668582 rs17855656 rs9668475 rs9668474 rs11044098
sequence:


uniprotID: O60447
geneSymbol: EVI5
name: Ecotropic viral integration site 5 protein homolog (EVI-5) (Neuroblastoma stage 4S gene protein)
length: 810
go: ENSG00000067208;
snps: rs1064580 rs2391199 rs11808092
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle [GO:0005819]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; intracellular protein transport [GO:0006886]; multicellular organism development [GO:0007275]; positive regulation of GTPase activity [GO:0043547]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60447-1; Sequence=Displayed; Name=2; IsoId=O60447-2; Sequence=VSP_056828; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.


uniprotID: Q8N9W8
geneSymbol: FAM71D
name: Protein FAM71D
length: 422
go: ENSG00000172717;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N9W8-1; Sequence=Displayed; Name=2; IsoId=Q8N9W8-2; Sequence=VSP_009298; Note=No experimental confirmation available.; 


uniprotID: Q01780
geneSymbol: EXOSC10
reactome: R-HSA-6791226;
pdb: 2CPR;3SAF;3SAG;3SAH;6D6Q;6D6R;
length: 885
go: ENSG00000171824;
name:
Exosome component 10 (EC 3.1.13.-) (Autoantigen PM/Scl 2) (P100 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 100 kDa) (PM/Scl-100) (Polymyositis/scleroderma autoantigen 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; membrane [GO:0016020]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]; 3'-5'-exoribonuclease activity [GO:0000175]; exoribonuclease activity [GO:0004532]; nucleotide binding [GO:0000166]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; CUT catabolic process [GO:0071034]; dosage compensation by inactivation of X chromosome [GO:0009048]; histone mRNA catabolic process [GO:0071044]; maturation of 5.8S rRNA [GO:0000460]; negative regulation of telomere maintenance via telomerase [GO:0032211]; nuclear mRNA surveillance [GO:0071028]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear retention of unspliced pre-mRNA at the site of transcription [GO:0071048]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of telomerase RNA localization to Cajal body [GO:1904872]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q01780-1; Sequence=Displayed; Name=2; IsoId=Q01780-2; Sequence=VSP_004362; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form.


uniprotID: O95677
geneSymbol: EYA4
reactome: R-HSA-5693565;
name: Eyes absent homolog 4 (EC 3.1.3.48)
length: 639
go: ENSG00000112319;
snps: rs9493627 rs779172192
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; protein tyrosine phosphatase activity [GO:0004725]; anatomical structure development [GO:0048856]; anatomical structure morphogenesis [GO:0009653]; DNA repair [GO:0006281]; histone dephosphorylation [GO:0016576]; multicellular organism development [GO:0007275]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; positive regulation of DNA repair [GO:0045739]; sensory perception of sound [GO:0007605]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=O95677-1; Sequence=Displayed; Name=2; IsoId=O95677-2; Sequence=VSP_001495, VSP_001496; Name=3; IsoId=O95677-3; Sequence=VSP_001497, VSP_001498; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=O95677-4; Sequence=VSP_001499; Name=5; IsoId=O95677-5; Sequence=VSP_042160, VSP_001499; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99502}. Nucleus {ECO:0000250|UniProtKB:Q99502}.


uniprotID: Q96GI7
geneSymbol: FAM89A
name: Protein FAM89A
length: 184
go: ENSG00000182118;
sequence:
MSGARAAPGAAGNGAVRGLRVDGLPPLPKSLSGLLHSASGGGASGGWRHLERLYAQKSRIQDELSRGGPGGGGARAAALPAKPPNLDAALALLRKEMVGLRQLDMSLLCQLYSLYESIQEYKGACQAASSPDCTYALENGFFDEEEEYFQEQNSLHDRRDRGPPRDLSLPVSSLSSSDWILESI


uniprotID: Q8WVX9
geneSymbol: FAR1
reactome: R-HSA-8848584;
name: Fatty acyl-CoA reductase 1 (EC 1.2.1.84) (Male sterility domain-containing protein 2)
length: 515
go: ENSG00000197601;
snps: rs12793516 rs724159963
sequence:

opentargets:
integral component of peroxisomal membrane [GO:0005779]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; alcohol-forming fatty acyl-CoA reductase activity [GO:0102965]; fatty-acyl-CoA reductase (alcohol-forming) activity [GO:0080019]; oxidoreductase activity [GO:0016491]; ether lipid biosynthetic process [GO:0008611]; glycerophospholipid biosynthetic process [GO:0046474]; long-chain fatty-acyl-CoA metabolic process [GO:0035336]; wax biosynthetic process [GO:0010025]

location:
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:24108123}; Single-pass membrane protein {ECO:0000269|PubMed:24108123}.


uniprotID: Q9NVQ4
geneSymbol: FAIM
pdb: 2KW1;3MX7;
name: Fas apoptotic inhibitory molecule 1
length: 179
go: ENSG00000158234;
snps: rs641320 rs13043
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:
MTDLVAVWDVALSDGVHKIEFEHGTTSGKRVVYVDGKEEIRKEWMFKLVGKETFYVGAAKTKATINIDAISGFAYEYTLEINGKSLKKYMEDRSKTTNTWVLHMDGENFRIVLEKDAMDVWCNGKKLETAGEFVDDGTETHFSIGNHDCYIKAVSSGKRKEGIIHTLIVDNREIPEIAS

opentargets:
cytoplasm [GO:0005737]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=FAIM-S; IsoId=Q9NVQ4-1; Sequence=Displayed; Name=2; IsoId=Q9NVQ4-2; Sequence=VSP_008991; Name=3; Synonyms=FAIM-L; IsoId=Q9NVQ4-3; Sequence=VSP_038095; 


uniprotID: Q9UNN5
geneSymbol: FAF1
pdb: 1H8C;2DZM;2EC4;3E21;3QC8;3QCA;3QQ8;3QWZ;3QX1;3R3M;
length: 650
go: ENSG00000185104;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26842564}.
name:
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)

sequence:

opentargets:
CD95 death-inducing signaling complex [GO:0031265]; cytosol [GO:0005829]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; heat shock protein binding [GO:0031072]; NF-kappaB binding [GO:0051059]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein kinase regulator activity [GO:0019887]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cell death [GO:0008219]; cytoplasmic sequestering of NF-kappaB [GO:0007253]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell death [GO:0010942]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of DNA replication [GO:0045740]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of protein complex assembly [GO:0031334]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of cell adhesion [GO:0030155]; regulation of protein catabolic process [GO:0042176]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=Q9UNN5-1; Sequence=Displayed; Name=Short; Synonyms=hFAF1(s); IsoId=Q9UNN5-2; Sequence=VSP_006704; Note=No experimental confirmation available.; 


uniprotID: Q96CS3
geneSymbol: FAF2
reactome: R-HSA-6798695;
pdb: 2DAM;
length: 445
go: ENSG00000113194;
name:
FAS-associated factor 2 (Protein ETEA) (UBX domain-containing protein 3B) (UBX domain-containing protein 8)

sequence:

opentargets:
azurophil granule lumen [GO:0035578]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; lipid droplet [GO:0005811]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; lipase binding [GO:0035473]; lipase inhibitor activity [GO:0055102]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; lipid droplet organization [GO:0034389]; neutrophil degranulation [GO:0043312]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12372427}. Lipid droplet {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:23297223}. Endoplasmic reticulum {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223}.


uniprotID: Q6NZ36
geneSymbol: FAAP20
reactome: R-HSA-6783310;
pdb: 2MUQ;2MUR;3WWQ;
length: 180
go: ENSG00000162585;
snps: rs1058411
name:
Fanconi anemia core complex-associated protein 20 (FANCA-associated protein of 20 kDa) (Fanconi anemia-associated protein of 20 kDa)

sequence:
MEAARRPRLGLSRRRPRPAGGPSGGRPWFLLGGDERERLWAELLRTVSPELILDHEVPSLPAFPGQEPRCGPEPTEVFTVGPKTFSWTPFPPDLWGPGRSYRLLHGAGGHLESPARSLPQRPAPDPCRAPRVEQQPSVEGAAALRSCPMCQKEFAPRLTQLDVDSHLAQCLAESTEDVTW

opentargets:
cell junction [GO:0030054]; chromosome [GO:0005694]; Fanconi anaemia nuclear complex [GO:0043240]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; ubiquitin binding [GO:0043130]; ubiquitin-dependent protein binding [GO:0140036]; cellular response to DNA damage stimulus [GO:0006974]; interstrand cross-link repair [GO:0036297]; translesion synthesis [GO:0019985]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q6NZ36-1; Sequence=Displayed; Name=2; IsoId=Q6NZ36-2; Sequence=VSP_030812; Name=3; IsoId=Q6NZ36-3; Sequence=VSP_030813; Note=No experimental confirmation available.; Name=4; IsoId=Q6NZ36-4; Sequence=VSP_030816; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q6NZ36-5; Sequence=VSP_030814, VSP_030815; Note=No experimental confirmation available.; Name=6; IsoId=Q6NZ36-6; Sequence=VSP_047264; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22343915, ECO:0000269|PubMed:22705371}. Chromosome {ECO:0000305|PubMed:22343915, ECO:0000305|PubMed:22705371}. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8. {ECO:0000269|PubMed:22705371}.


uniprotID: Q92520
geneSymbol: FAM3C
reactome: R-HSA-114608;
pdb: 5LC2;
name: Protein FAM3C (Interleukin-like EMT inducer)
length: 227
go: ENSG00000196937;
sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; platelet dense granule lumen [GO:0031089]; cytokine activity [GO:0005125]; multicellular organism development [GO:0007275]; negative regulation of gluconeogenesis [GO:0045721]; platelet degranulation [GO:0002576]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasmic vesicle {ECO:0000269|PubMed:16959614}. Note=Cytoplasmic in some cancer cells.


uniprotID: Q96BQ1
geneSymbol: FAM3D
name: Protein FAM3D
length: 224
go: ENSG00000198643;
snps: rs17059569 rs33966924
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; cytokine activity [GO:0005125]; negative regulation of glucagon secretion [GO:0070093]; negative regulation of insulin secretion [GO:0046676]


uniprotID: Q5TZK3
geneSymbol: FAM74A4; FAM74A6
name: Protein FAM74A4/A6
length: 123
sequence:
MWRELRGCPGGDVETAQRLSQRRRGKSSEAVPEKTWRAQRMSQRRRGESSEAVPEKTWKELRNSETVPEKTWKQLRGCLQEDVQRVQRLSRRRHGESSKAVHKKMWREFRGCRYCCTWLFFFG


uniprotID: P57775
geneSymbol: FBXW4
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
name: F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
length: 412
go: ENSG00000107829;
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; cartilage development [GO:0051216]; embryonic digit morphogenesis [GO:0042733]; embryonic limb morphogenesis [GO:0030326]; positive regulation of mesenchymal cell proliferation [GO:0002053]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]; Wnt signaling pathway [GO:0016055]


uniprotID: Q7L513
geneSymbol: FCRLA
pdb: 4HWN;
length: 359
go: ENSG00000132185;
opentargets: cytoplasm [GO:0005737]; cell differentiation [GO:0030154]
snps: rs11746
name:
Fc receptor-like A (Fc receptor homolog expressed in B-cells) (Fc receptor-like and mucin-like protein 1) (Fc receptor-like protein) (Fc receptor-related protein X) (FcRX)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=15;  Name=1; Synonyms=FCRLa; IsoId=Q7L513-1; Sequence=Displayed; Name=2; Synonyms=FCRLa1; IsoId=Q7L513-2; Sequence=VSP_017605; Name=3; Synonyms=FCRLb; IsoId=Q7L513-3; Sequence=VSP_017608; Name=4; Synonyms=FCRLc1; IsoId=Q7L513-4; Sequence=VSP_017606; Name=5; Synonyms=FCRLc2; IsoId=Q7L513-5; Sequence=VSP_017604; Name=6; Synonyms=FCRLd; IsoId=Q7L513-6; Sequence=VSP_017607; Name=7; Synonyms=FCRLe; IsoId=Q7L513-7; Sequence=VSP_017603; Name=8; Synonyms=FCRLf; IsoId=Q7L513-8; Sequence=VSP_017609; Name=9; IsoId=Q7L513-9; Sequence=VSP_038297; Name=10; IsoId=Q7L513-10; Sequence=VSP_038297, VSP_017605; Note=No experimental confirmation available.; Name=11; IsoId=Q7L513-11; Sequence=VSP_038297, VSP_017606; Note=No experimental confirmation available.; Name=12; IsoId=Q7L513-12; Sequence=VSP_038297, VSP_017608; Note=No experimental confirmation available.; Name=13; IsoId=Q7L513-13; Sequence=VSP_038297, VSP_017607; Note=No experimental confirmation available.; Name=14; IsoId=Q7L513-14; Sequence=VSP_038297, VSP_017604; Note=No experimental confirmation available.; Name=15; IsoId=Q7L513-15; Sequence=VSP_038297, VSP_017603; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11754007, ECO:0000269|PubMed:11891275, ECO:0000269|PubMed:15551350}. Note=Seems not to be secreted. {ECO:0000269|PubMed:11891275}.


uniprotID: Q9NRD0
geneSymbol: FBXO8
name: F-box only protein 8 (F-box/SEC7 protein FBS)
length: 319
go: ENSG00000164117;
snps: rs17857220 rs17854000
sequence:

opentargets:
ubiquitin ligase complex [GO:0000151]; ARF guanyl-nucleotide exchange factor activity [GO:0005086]; regulation of ARF protein signal transduction [GO:0032012]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NRD0-1; Sequence=Displayed; Name=2; IsoId=Q9NRD0-2; Sequence=VSP_055885; Note=No experimental confirmation available.; 


uniprotID: O94868
geneSymbol: FCHSD2
pdb: 2DL5;2DL7;6GBU;
name: F-BAR and double SH3 domains protein 2 (Carom) (SH3 multiple domains protein 3)
length: 740
go: ENSG00000137478;
sequence:

opentargets:
neuromuscular junction [GO:0031594]; recycling endosome [GO:0055037]; neuromuscular synaptic transmission [GO:0007274]; regulation of actin filament polymerization [GO:0030833]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O94868-1; Sequence=Displayed; Name=2; IsoId=O94868-2; Sequence=VSP_023167; Name=3; IsoId=O94868-3; Sequence=VSP_023167, VSP_023168, VSP_023169; 


uniprotID: Q9HAH7
geneSymbol: FBRS
name: Probable fibrosin-1
length: 460
go: ENSG00000156860;
sequence:

opentargets:
extracellular space [GO:0005615]; growth factor activity [GO:0008083]; positive regulation of fibroblast proliferation [GO:0048146]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=Q9HAH7-2; Sequence=Displayed; Name=1; IsoId=Q9HAH7-1; Sequence=VSP_010991; Note=No experimental confirmation available.; 


uniprotID: O75426
geneSymbol: FBXO24
name: F-box only protein 24
length: 580
go: ENSG00000106336;
snps: rs7801492
sequence:

opentargets:
ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O75426-1; Sequence=Displayed; Name=2; IsoId=O75426-2; Sequence=VSP_011351, VSP_011352, VSP_011353; Name=3; IsoId=O75426-3; Sequence=VSP_043459; Note=No experimental confirmation available.; Name=4; IsoId=O75426-4; Sequence=VSP_043458; Note=No experimental confirmation available.; 


uniprotID: P12319
geneSymbol: FCER1A
reactome: R-HSA-2454202;R-HSA-2730905;R-HSA-2871796;R-HSA-2871809;R-HSA-2871837;
pdb: 1ALS;1ALT;1F2Q;1F6A;1J86;1J87;1J88;1J89;1RPQ;2Y7Q;
length: 257
go: ENSG00000179639;
drug: DB00895;DB00043;DB05797;
snps: rs2298804 rs2298805
location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
name:
High affinity immunoglobulin epsilon receptor subunit alpha (Fc-epsilon RI-alpha) (FcERI) (IgE Fc receptor subunit alpha)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; IgE binding [GO:0019863]; Fc-epsilon receptor signaling pathway [GO:0038095]


uniprotID: Q6P4F2
geneSymbol: FDX2
reactome: R-HSA-1362409;R-HSA-196108;R-HSA-211976;R-HSA-2395516;R-HSA-5579026;
pdb: 2Y5C;
name: Ferredoxin-2, mitochondrial (Adrenodoxin-like protein) (Ferredoxin-1-like protein)
length: 186
go: ENSG00000267673;
sequence:
MHVMAASMARGGVSARVLLQAARGTWWNRPGGTSGSGEGVALGTTRKFQATGSRPAGEEDAGGPERPGDVVNVVFVDRSGQRIPVSGRVGDNVLHLAQRHGVDLEGACEASLACSTCHVYVSEDHLDLLPPPEEREDDMLDMAPLLQENSRLGCQIVLTPELEGAEFTLPKITRNFYVDGHVPKPH

opentargets:
mitochondrial matrix [GO:0005759]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; metal ion binding [GO:0046872]; C21-steroid hormone biosynthetic process [GO:0006700]; small molecule metabolic process [GO:0044281]; sterol metabolic process [GO:0016125]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P4F2-1; Sequence=Displayed; Name=2; IsoId=Q6P4F2-2; Sequence=VSP_056826; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20547883}. Mitochondrion matrix {ECO:0000250}.


uniprotID: Q9BSK4
geneSymbol: FEM1A
reactome: R-HSA-8951664;
name: Protein fem-1 homolog A (FEM1a) (FEM1-alpha) (Prostaglandin E receptor 4-associated protein)
length: 669
go: ENSG00000141965;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; EP4 subtype prostaglandin E2 receptor binding [GO:0031867]; ubiquitin-protein transferase activity [GO:0004842]; negative regulation of inflammatory response [GO:0050728]; post-translational protein modification [GO:0043687]; regulation of ubiquitin-protein transferase activity [GO:0051438]


uniprotID: A6NFA0
geneSymbol: FAM205C
name: Protein FAM205C (FAM205C pseudogene)
length: 338
go: ENSG00000187791;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8TAG9
geneSymbol: EXOC6
reactome: R-HSA-1445148;R-HSA-264876;R-HSA-5620916;
name: Exocyst complex component 6 (Exocyst complex component Sec15A) (SEC15-like protein 1)
length: 804
go: ENSG00000138190;
snps: rs1326331 rs11187225 rs35647717
sequence:

opentargets:
cytosol [GO:0005829]; exocyst [GO:0000145]; Flemming body [GO:0090543]; growth cone [GO:0030426]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; exocytosis [GO:0006887]; Golgi to plasma membrane transport [GO:0006893]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TAG9-1; Sequence=Displayed; Name=2; IsoId=Q8TAG9-2; Sequence=VSP_047160; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54923}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54923}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54923}. Midbody, Midbody ring {ECO:0000269|PubMed:16213214}. Note=Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). {ECO:0000250|UniProtKB:O54923, ECO:0000269|PubMed:16213214}.


uniprotID: A5PLN7
geneSymbol: FAM149A
name: Protein FAM149A
length: 773
go: ENSG00000109794;
snps: rs4862650 rs4862653 rs2276924 rs2276922 rs9991339 rs6818265
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=A5PLN7-1; Sequence=Displayed; Name=2; IsoId=A5PLN7-2; Sequence=VSP_031530; Name=3; IsoId=A5PLN7-3; Sequence=VSP_031532; Name=4; IsoId=A5PLN7-4; Sequence=VSP_031531; Note=No experimental confirmation available.; 


uniprotID: A6NNH2
geneSymbol: FAM90A27P
name: Protein FAM90A27P
length: 459
sequence:


uniprotID: P43268
geneSymbol: ETV4
reactome: R-HSA-5687128;
pdb: 4CO8;4UUV;5ILU;
length: 484
go: ENSG00000175832;
snps: rs150119757 rs34260468
location: SUBCELLULAR LOCATION: Nucleus.
name:
ETS translocation variant 4 (Adenovirus E1A enhancer-binding protein) (E1A-F) (Polyomavirus enhancer activator 3 homolog) (Protein PEA3)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P43268-1; Sequence=Displayed; Name=2; IsoId=P43268-2; Sequence=VSP_046036; Note=No experimental confirmation available.; Name=3; IsoId=P43268-3; Sequence=VSP_055314; Note=No experimental confirmation available.; 


uniprotID: A8MVW0
geneSymbol: FAM171A2
name: Protein FAM171A2
length: 826
go: ENSG00000161682;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: A6NEL3
geneSymbol: FAM86C2P
name: Putative protein FAM86C2P (EC 2.1.1.-)
length: 165
opentargets: methyltransferase activity [GO:0008168]
sequence:
MAPEENAGTELLLQSLERRFLAARALRSFPWQSLEAKLRDSSDSELLRDILQKHEAVHTEPLDELYEVLAETLMAKESTQGHRSYLLTCCIAQKPSCRWSGSCGGWLPAGSTSGLLKSMWPLPSATQRRASCSPLSYAGLGSDGKWNLVMTRNCFPTKSTWRWQC


uniprotID: A6NJQ4
geneSymbol: FAM90A8P
name: Putative protein FAM90A8P
length: 464
sequence:


uniprotID: Q9UBU6
geneSymbol: FAM8A1
name: Protein FAM8A1 (Autosomal highly conserved protein)
length: 413
go: ENSG00000137414;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q14153
geneSymbol: FAM53B
name: Protein FAM53B (Protein simplet)
length: 422
go: ENSG00000189319;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25183871}.
sequence:

opentargets:
nucleus [GO:0005634]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; regulation of canonical Wnt signaling pathway [GO:0060828]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14153-1; Sequence=Displayed; Name=2; IsoId=Q14153-2; Sequence=VSP_009932, VSP_009933; Note=No experimental confirmation available.; 


uniprotID: Q8N3Y1
geneSymbol: FBXW8
reactome: R-HSA-8951664;R-HSA-983168;
length: 598
go: ENSG00000174989;
snps: rs4076700 rs36021180 rs3741466 rs56350562
name:
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)

sequence:

opentargets:
Cul7-RING ubiquitin ligase complex [GO:0031467]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; cell proliferation [GO:0008283]; Golgi organization [GO:0007030]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of transcription factor catabolic process [GO:1901485]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; spongiotrophoblast layer development [GO:0060712]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N3Y1-1; Sequence=Displayed; Name=2; IsoId=Q8N3Y1-2; Sequence=VSP_008501; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:21572988}. Golgi apparatus {ECO:0000269|PubMed:21572988}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {ECO:0000250|UniProtKB:P0DL28}.


uniprotID: P08637
geneSymbol: FCGR3A
reactome: R-HSA-198933;R-HSA-2029481;R-HSA-2029482;R-HSA-2029485;
pdb: 3AY4;3SGJ;3SGK;3WN5;5BW7;5D6D;5ML9;5MN2;5XJE;5XJF;5YC5;
length: 254
go: ENSG00000203747;
snps: rs10127939 rs10127939 rs443082 rs396716 rs396991 rs1042206
name:
Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a antigen) (Fc-gamma RIII-alpha) (Fc-gamma RIII) (Fc-gamma RIIIa) (FcRIII) (FcRIIIa) (FcR-10) (IgG Fc receptor III-2) (CD antigen CD16a)

sequence:

opentargets:
external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; IgG binding [GO:0019864]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response [GO:0006955]; regulation of immune response [GO:0050776]

drug:
DB00054;DB00051;DB00092;DB00087;DB00074;DB00112;DB00002;DB00111;DB00095;DB00005;DB00056;DB00078;DB00028;DB00075;DB00108;DB00110;DB00073;DB00081;DB00072;

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Exists also as a soluble receptor.


uniprotID: O75015
geneSymbol: FCGR3B
reactome: R-HSA-163125;R-HSA-6798695;
pdb: 1E4J;1E4K;1FNL;1T83;1T89;
length: 233
snps: rs448740 rs5030738
name:
Low affinity immunoglobulin gamma Fc region receptor III-B (Fc-gamma RIII-beta) (Fc-gamma RIII) (Fc-gamma RIIIb) (FcRIII) (FcRIIIb) (FcR-10) (IgG Fc receptor III-1) (CD antigen CD16b)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; IgG binding [GO:0019864]; immune response [GO:0006955]; neutrophil degranulation [GO:0043312]

drug:
DB00054;DB00051;DB00092;DB00087;DB00074;DB00112;DB00002;DB00111;DB00095;DB00005;DB00056;DB00078;DB00028;DB00075;DB00108;DB00110;DB00073;DB00081;DB00072;

location:
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.


uniprotID: O75636
geneSymbol: FCN3
reactome: R-HSA-166662;R-HSA-166663;R-HSA-2855086;
pdb: 1LA5;2J5Z;2J60;2J64;
length: 299
go: ENSG00000142748;
location: SUBCELLULAR LOCATION: Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct.
name:
Ficolin-3 (Collagen/fibrinogen domain-containing lectin 3 p35) (Collagen/fibrinogen domain-containing protein 3) (Hakata antigen)

sequence:

opentargets:
blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; extracellular region [GO:0005576]; antigen binding [GO:0003823]; carbohydrate binding [GO:0030246]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; defense response to virus [GO:0051607]; negative regulation of RNA biosynthetic process [GO:1902679]; negative regulation of viral entry into host cell [GO:0046597]; recognition of apoptotic cell [GO:0043654]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75636-1; Sequence=Displayed; Name=2; IsoId=O75636-2; Sequence=VSP_001541; 


uniprotID: Q4G163
geneSymbol: FBXO43
name: F-box only protein 43 (Endogenous meiotic inhibitor 2)
length: 708
go: ENSG00000156509;
snps: rs2279102 rs2279102
sequence:

opentargets:
nucleus [GO:0005634]; metal ion binding [GO:0046872]; meiotic cell cycle [GO:0051321]; negative regulation of meiotic nuclear division [GO:0045835]; protein ubiquitination [GO:0016567]


uniprotID: Q6PJ61
geneSymbol: FBXO46
name: F-box only protein 46 (F-box only protein 34-like)
length: 603
go: ENSG00000177051;
sequence:


uniprotID: Q92637
geneSymbol: FCGR1B
reactome: R-HSA-1236978;R-HSA-877300;
length: 280
go: ENSG00000198019;
drug: DB00028;
name:
High affinity immunoglobulin gamma Fc receptor IB (IgG Fc receptor IB) (Fc-gamma RIB) (FcRIB) (hFcgammaRIB)

sequence:

opentargets:
clathrin-coated endocytic vesicle membrane [GO:0030669]; early endosome membrane [GO:0031901]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; IgG binding [GO:0019864]; immunoglobulin receptor activity [GO:0019763]; adaptive immune response [GO:0002250]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; immune response [GO:0006955]; interferon-gamma-mediated signaling pathway [GO:0060333]; receptor-mediated endocytosis [GO:0006898]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=b2; IsoId=Q92637-1; Sequence=Displayed; Name=2; IsoId=Q92637-2; Sequence=VSP_033216, VSP_033217; Name=3; Synonyms=b3; IsoId=Q92637-3; Sequence=VSP_033215; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1430234}; Single-pass type I membrane protein {ECO:0000269|PubMed:1430234}.


uniprotID: O14526
geneSymbol: FCHO1
reactome: R-HSA-8856825;R-HSA-8856828;
name: F-BAR domain only protein 1
length: 889
go: ENSG00000130475;
sequence:

opentargets:
AP-2 adaptor complex [GO:0030122]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; AP-2 adaptor complex binding [GO:0035612]; cytoskeletal protein binding [GO:0008092]; microtubule binding [GO:0008017]; phospholipid binding [GO:0005543]; tubulin binding [GO:0015631]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; plasma membrane tubulation [GO:0097320]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O14526-1; Sequence=Displayed; Name=2; IsoId=O14526-2; Sequence=VSP_022338; Note=No experimental confirmation available.; Name=3; IsoId=O14526-3; Sequence=VSP_046906; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Peripheral membrane protein {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}; Cytoplasmic side {ECO:0000305|PubMed:17617719, ECO:0000305|PubMed:20448150}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to PubMed:17617719 it may also dynamically associate with Golgi/TGN membranes.


uniprotID: Q96JP0
geneSymbol: FEM1C
reactome: R-HSA-8951664;
name: Protein fem-1 homolog C (FEM1c) (FEM1-gamma)
length: 617
go: ENSG00000145780;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; post-translational protein modification [GO:0043687]; protein ubiquitination [GO:0016567]


uniprotID: P39748
geneSymbol: FEN1
reactome: R-HSA-110362;R-HSA-162594;R-HSA-174437;R-HSA-5651801;R-HSA-5685939;R-HSA-69166;
pdb: 1U7B;1UL1;3Q8K;3Q8L;3Q8M;3UVU;5E0V;5FV7;5K97;5KSE;5UM9;
length: 380
go: ENSG00000168496;
name:
Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (DNase IV) (Flap structure-specific endonuclease 1) (Maturation factor 1) (MF1) (hFEN-1)

sequence:

opentargets:
membrane [GO:0016020]; mitochondrion [GO:0005739]; nuclear chromosome, telomeric region [GO:0000784]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; 5'-3' exonuclease activity [GO:0008409]; 5'-flap endonuclease activity [GO:0017108]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0051908]; double-stranded DNA binding [GO:0003690]; double-stranded DNA exodeoxyribonuclease activity [GO:0008309]; endonuclease activity [GO:0004519]; exonuclease activity [GO:0004527]; flap endonuclease activity [GO:0048256]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; single-stranded DNA 5'-3' exodeoxyribonuclease activity [GO:0045145]; apoptotic DNA fragmentation [GO:0006309]; base-excision repair [GO:0006284]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; memory [GO:0007613]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of sister chromatid cohesion [GO:0045876]; telomere maintenance via semi-conservative replication [GO:0032201]; UV protection [GO:0009650]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=1; IsoId=P39748-1; Sequence=Displayed; Name=FENMIT; IsoId=P39748-2; Sequence=VSP_047520; Note=No nuclease activity. Binds preferentially to RNA flap structures and R-loops.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.; SUBCELLULAR LOCATION: Isoform FENMIT: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:23675412}.


uniprotID: Q5NUL3
geneSymbol: FFAR4
reactome: R-HSA-381771;R-HSA-416476;R-HSA-444209;
length: 377
go: ENSG00000186188;
drug: DB05793;DB05435;
snps: rs61866610 rs116454156
name:
Free fatty acid receptor 4 (G-protein coupled receptor 120) (G-protein coupled receptor 129) (G-protein coupled receptor GT01) (G-protein coupled receptor PGR4) (Omega-3 fatty acid receptor 1)

sequence:

opentargets:
endocytic vesicle [GO:0030139]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; fatty acid binding [GO:0005504]; G protein-coupled receptor activity [GO:0004930]; taste receptor activity [GO:0008527]; fat cell differentiation [GO:0045444]; G protein-coupled receptor signaling pathway [GO:0007186]; hormone secretion [GO:0046879]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cytokine secretion [GO:0050710]; negative regulation of inflammatory response [GO:0050728]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; regulation of glucose transmembrane transport [GO:0010827]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5NUL3-1; Sequence=Displayed; Note=Specific to human.; Name=2; IsoId=Q5NUL3-2; Sequence=VSP_013684; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalized with ARRB2 following DHA treatment. {ECO:0000250}.


uniprotID: Q02985
geneSymbol: CFHR3
reactome: R-HSA-977606;
name: Complement factor H-related protein 3 (FHR-3) (DOWN16) (H factor-like protein 3)
length: 330
go: ENSG00000116785;
snps: rs17575274
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
blood microparticle [GO:0072562]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q02985-1; Sequence=Displayed; Name=2; IsoId=Q02985-2; Sequence=VSP_043041; Note=No experimental confirmation available.; 


uniprotID: P50502
geneSymbol: ST13
reactome: R-HSA-3371453;
pdb: 1UZS;
length: 369
go: ENSG00000100380;
snps: rs710193
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; protein-containing complex [GO:0032991]; chaperone binding [GO:0051087]; dATP binding [GO:0032564]; Hsp70 protein binding [GO:0030544]; identical protein binding [GO:0042802]; protein binding, bridging [GO:0030674]; protein dimerization activity [GO:0046983]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; unfolded protein binding [GO:0051082]; chaperone cofactor-dependent protein refolding [GO:0051085]; negative regulation of protein refolding [GO:0061084]; protein folding [GO:0006457]; protein homotetramerization [GO:0051289]; response to bacterium [GO:0009617]


uniprotID: Q6PEV8
geneSymbol: FAM199X
name: Protein FAM199X
length: 388
go: ENSG00000123575;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6PEV8-1; Sequence=Displayed; Name=2; IsoId=Q6PEV8-2; Sequence=VSP_020747; Note=No experimental confirmation available.; 


uniprotID: Q6ZN32
geneSymbol: ETV3L
name: ETS translocation variant 3-like protein
length: 361
go: ENSG00000253831;
snps: rs16838078 rs12083811 rs12136960 rs12126791
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; sequence-specific DNA binding [GO:0043565]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]


uniprotID: A6NEQ2
geneSymbol: FAM181B
name: Protein FAM181B
length: 426
go: ENSG00000182103;
snps: rs986097 rs6592081
sequence:


uniprotID: Q9Y2C4
geneSymbol: EXOG
pdb: 4A1N;5T3V;5T40;5T4I;5T5C;
name: Nuclease EXOG, mitochondrial (EC 3.1.30.-) (Endonuclease G-like 1) (Endo G-like 1)
length: 368
go: ENSG00000157036;
snps: rs1141223
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18187503}.
sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; 5'-3' exonuclease activity [GO:0008409]; endonuclease activity [GO:0004519]; endoribonuclease activity [GO:0004521]; exodeoxyribonuclease activity [GO:0004529]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; single-stranded DNA endodeoxyribonuclease activity [GO:0000014]; apoptotic DNA fragmentation [GO:0006309]; DNA catabolic process, endonucleolytic [GO:0000737]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=ENGL-a; IsoId=Q9Y2C4-1; Sequence=Displayed; Name=2; Synonyms=ENDOGL2, ENGL-b; IsoId=Q9Y2C4-2; Sequence=VSP_034506, VSP_034507, VSP_034508; Note=No experimental confirmation available. Probably inactive since it lacks the active site.; Name=3; IsoId=Q9Y2C4-3; Sequence=VSP_034506; Note=Probably inactive since it lacks the active site.; Name=4; IsoId=Q9Y2C4-4; Sequence=VSP_041214; 


uniprotID: Q96CN4
geneSymbol: EVI5L
name: EVI5-like protein (Ecotropic viral integration site 5-like protein)
length: 794
go: ENSG00000142459;
sequence:

opentargets:
intracellular [GO:0005622]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; negative regulation of cilium assembly [GO:1902018]; positive regulation of GTPase activity [GO:0043547]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96CN4-1; Sequence=Displayed; Name=2; IsoId=Q96CN4-2; Sequence=VSP_043456; Note=No experimental confirmation available.; 


uniprotID: P0C7W8
geneSymbol: FAM90A13P
name: Putative protein FAM90A13P
length: 464
sequence:


uniprotID: P0C7W9
geneSymbol: FAM90A14P
name: Putative protein FAM90A14P
length: 464
sequence:


uniprotID: A6NEW6
geneSymbol: FAM90A16P; FAM90A17P
name: Putative protein FAM90A16P/FAM90A17P
length: 464
sequence:


uniprotID: Q6NSI3
geneSymbol: FAM53A
name: Protein FAM53A (Dorsal neural-tube nuclear protein)
length: 398
go: ENSG00000174137;
opentargets: nucleus [GO:0005634]
sequence:

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5ZKN5}. Note=Subnuclear distribution. {ECO:0000250|UniProtKB:Q5ZKN5}.


uniprotID: O15540
geneSymbol: FABP7
reactome: R-HSA-163560;R-HSA-9013508;
pdb: 1FDQ;1FE3;1JJX;5URA;
length: 132
go: ENSG00000164434;
drug: DB00132;DB00154;DB00159;DB04224;
snps: rs2279381
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Fatty acid-binding protein, brain (Brain lipid-binding protein) (BLBP) (Brain-type fatty acid-binding protein) (B-FABP) (Fatty acid-binding protein 7) (Mammary-derived growth inhibitor related)

sequence:
MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKNTEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTFGDVVAVRHYEKA

opentargets:
cell periphery [GO:0071944]; cell projection [GO:0042995]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; lipid binding [GO:0008289]; cell proliferation in forebrain [GO:0021846]; epithelial cell proliferation [GO:0050673]; negative regulation of cell proliferation [GO:0008285]; nervous system development [GO:0007399]; neurogenesis [GO:0022008]; prepulse inhibition [GO:0060134]; triglyceride catabolic process [GO:0019433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15540-1; Sequence=Displayed; Name=2; IsoId=O15540-2; Sequence=VSP_055490; 


uniprotID: O60427
geneSymbol: FADS1
reactome: R-HSA-1989781;R-HSA-2046105;R-HSA-2046106;
length: 444
go: ENSG00000149485;
drug: DB00132;DB00159;
snps: rs17856235
name:
Fatty acid desaturase 1 (EC 1.14.19.-) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; mitochondrion [GO:0005739]; C-5 sterol desaturase activity [GO:0000248]; omega-6 fatty acid desaturase activity [GO:0045485]; oxidoreductase activity [GO:0016491]; alpha-linolenic acid metabolic process [GO:0036109]; cell-cell signaling [GO:0007267]; cellular response to starvation [GO:0009267]; icosanoid biosynthetic process [GO:0046456]; linoleic acid metabolic process [GO:0043651]; phospholipid biosynthetic process [GO:0008654]; regulation of cell differentiation [GO:0045595]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription, DNA-templated [GO:0006355]; unsaturated fatty acid biosynthetic process [GO:0006636]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=FADS1CS; IsoId=O60427-1; Sequence=Displayed; Name=2; Synonyms=FADS1AT1; IsoId=O60427-2; Sequence=VSP_047521; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}. Mitochondrion {ECO:0000269|PubMed:22619218}.; SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A4UVI1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A4UVI1}.


uniprotID: Q05397
geneSymbol: PTK2
length: 1052
go: ENSG00000169398;
drug: DB07460;
reactome:
R-HSA-111465;R-HSA-2029482;R-HSA-354192;R-HSA-354194;R-HSA-372708;R-HSA-375165;R-HSA-391160;R-HSA-3928662;R-HSA-418885;R-HSA-4420097;R-HSA-5663213;R-HSA-5673001;R-HSA-8874081;

pdb:
1K04;1K05;1MP8;1OW6;1OW7;1OW8;2ETM;2IJM;3B71;3BZ3;3PXK;3S9O;4EBV;4EBW;4GU6;4GU9;4I4E;4I4F;4K8A;4K9Y;4KAB;4KAO;4NY0;4Q9S;

name:
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; actin binding [GO:0003779]; ATP binding [GO:0005524]; JUN kinase binding [GO:0008432]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; SH2 domain binding [GO:0042169]; angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell differentiation [GO:0030154]; cell motility [GO:0048870]; central nervous system neuron axonogenesis [GO:0021955]; endothelial cell migration [GO:0043542]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; establishment of cell polarity [GO:0030010]; extracellular matrix organization [GO:0030198]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; growth hormone receptor signaling pathway [GO:0060396]; heart morphogenesis [GO:0003007]; integrin-mediated signaling pathway [GO:0007229]; MAPK cascade [GO:0000165]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of autophagy [GO:0010507]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of organ growth [GO:0046621]; negative regulation of synapse assembly [GO:0051964]; netrin-activated signaling pathway [GO:0038007]; neuron migration [GO:0001764]; nuclear migration [GO:0007097]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; placenta development [GO:0001890]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; protein autophosphorylation [GO:0046777]; regulation of cell adhesion [GO:0030155]; regulation of cell adhesion mediated by integrin [GO:0033628]; regulation of cell proliferation [GO:0042127]; regulation of cell shape [GO:0008360]; regulation of cytoskeleton organization [GO:0051493]; regulation of endothelial cell migration [GO:0010594]; regulation of epithelial cell migration [GO:0010632]; regulation of focal adhesion assembly [GO:0051893]; regulation of GTPase activity [GO:0043087]; regulation of osteoblast differentiation [GO:0045667]; regulation of protein phosphorylation [GO:0001932]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; signal complex assembly [GO:0007172]; transforming growth factor beta receptor signaling pathway [GO:0007179]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q05397-1; Sequence=Displayed; Name=2; IsoId=Q05397-2; Sequence=VSP_004967, VSP_004968, VSP_004969, VSP_004970; Name=3; IsoId=Q05397-3; Sequence=VSP_004967, VSP_004968, VSP_004969, VSP_004973, VSP_004974; Name=4; IsoId=Q05397-4; Sequence=VSP_004967, VSP_004968, VSP_004969, VSP_004971, VSP_004972; Name=5; IsoId=Q05397-5; Sequence=VSP_042169, VSP_042170; Name=6; Synonyms=FRNK; IsoId=Q05397-6; Sequence=VSP_042168; Note=Produced by alternative promoter usage.; Name=7; IsoId=Q05397-7; Sequence=VSP_057268; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus. Note=Constituent of focal adhesions. Detected at microtubules.


uniprotID: Q9HB96
geneSymbol: FANCE
reactome: R-HSA-6783310;
pdb: 2ILR;
name: Fanconi anemia group E protein (Protein FACE)
length: 536
go: ENSG00000112039;
snps: rs45600543 rs7761870 rs45524646 rs45467798 rs9462088
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12093742, ECO:0000269|PubMed:17296736}.
sequence:

opentargets:
Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; interstrand cross-link repair [GO:0036297]


uniprotID: Q6ZVX7
geneSymbol: NCCRP1
length: 275
go: ENSG00000188505;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22087255}.
name:
F-box only protein 50 (NCC receptor protein 1 homolog) (NCCRP-1) (Non-specific cytotoxic cell receptor protein 1 homolog)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; positive regulation of cell proliferation [GO:0008284]


uniprotID: Q5T0N5
geneSymbol: FNBP1L
reactome: R-HSA-8856828;
name: Formin-binding protein 1-like (Transducer of Cdc42-dependent actin assembly protein 1) (Toca-1)
length: 605
go: ENSG00000137942;
sequence:

opentargets:
cell cortex [GO:0005938]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; GTPase binding [GO:0051020]; lipid binding [GO:0008289]; autophagy [GO:0006914]; cilium assembly [GO:0060271]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; membrane organization [GO:0061024]; plasma membrane tubulation [GO:0097320]; positive regulation of filopodium assembly [GO:0051491]; vesicle budding from membrane [GO:0006900]; vesicle organization [GO:0016050]; vesicle transport along actin filament [GO:0030050]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q5T0N5-1; Sequence=Displayed; Note=Gene prediction based on EST data.; Name=2; IsoId=Q5T0N5-2; Sequence=VSP_021710; Note=Gene prediction based on EST data.; Name=3; IsoId=Q5T0N5-3; Sequence=VSP_021709; Name=4; IsoId=Q5T0N5-4; Sequence=VSP_021709, VSP_021711; Note=Gene prediction based on EST data.; Name=5; IsoId=Q5T0N5-5; Sequence=VSP_021710, VSP_021711; Note=Gene prediction based on EST data. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q6DN72
geneSymbol: FCRL6
name: Fc receptor-like protein 6 (FcR-like protein 6) (FcRL6) (Fc receptor homolog 6) (FcRH6) (IFGP6)
length: 434
go: ENSG00000181036;
snps: rs4443889
sequence:

opentargets:
external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; MHC class II protein binding [GO:0042289]; phosphatase binding [GO:0019902]; protein phosphatase binding [GO:0019903]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=FCRL6v1 {ECO:0000303|PubMed:20933011}; IsoId=Q6DN72-1; Sequence=Displayed; Name=2; IsoId=Q6DN72-2; Sequence=VSP_023565, VSP_023568, VSP_023570; Name=3; Synonyms=FCRL6v4 {ECO:0000303|PubMed:20933011}; IsoId=Q6DN72-3; Sequence=VSP_023567, VSP_023569; Name=4; IsoId=Q6DN72-4; Sequence=VSP_023566, VSP_023568, VSP_023570; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20933011}; Single-pass type I membrane protein {ECO:0000305}.


uniprotID: O00602
geneSymbol: FCN1
reactome: R-HSA-166662;R-HSA-166663;R-HSA-2855086;R-HSA-6798695;
pdb: 2D39;2JHH;2JHI;2JHK;2JHL;2JHM;2WNP;
name: Ficolin-1 (Collagen/fibrinogen domain-containing protein 1) (Ficolin-A) (Ficolin-alpha) (M-ficolin)
length: 326
go: ENSG00000085265;
snps: rs56345770 rs771359747
sequence:

opentargets:
collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; extrinsic component of external side of plasma membrane [GO:0031232]; ficolin-1-rich granule lumen [GO:1904813]; secretory granule lumen [GO:0034774]; carbohydrate binding [GO:0030246]; G protein-coupled receptor binding [GO:0001664]; metal ion binding [GO:0046872]; serine-type endopeptidase activity [GO:0004252]; sialic acid binding [GO:0033691]; signaling pattern recognition receptor activity [GO:0008329]; cell surface pattern recognition receptor signaling pathway [GO:0002752]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of viral entry into host cell [GO:0046597]; neutrophil degranulation [GO:0043312]; positive regulation of interleukin-8 secretion [GO:2000484]; protein localization to cell surface [GO:0034394]; recognition of apoptotic cell [GO:0043654]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Cell membrane {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}; Peripheral membrane protein {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}; Extracellular side {ECO:0000269|PubMed:20400674, ECO:0000269|PubMed:21037097}. Note=Found on the monocyte and granulocyte surface (PubMed:20400674).


uniprotID: Q9UK96
geneSymbol: FBXO10
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 10
length: 956
go: ENSG00000147912;
snps: rs780121584 rs7044561 rs573535073
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23431138}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of apoptotic process [GO:0042981]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UK96-1; Sequence=Displayed; Name=2; IsoId=Q9UK96-2; Sequence=VSP_056318; Note=No experimental confirmation available.; 


uniprotID: Q5XUX1
geneSymbol: FBXW9
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
name: F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9)
length: 488
go: ENSG00000132004;
snps: rs6511833 rs10424623
sequence:

opentargets:
cytosol [GO:0005829]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5XUX1-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q5XUX1-2; Sequence=VSP_020428; Note=No experimental confirmation available.; Name=3; IsoId=Q5XUX1-3; Sequence=VSP_020429; 


uniprotID: Q9H4M3
geneSymbol: FBXO44
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 3WSO;5B4N;
name: F-box only protein 44 (F-box protein FBX30) (F-box/G-domain protein 3)
length: 255
go: ENSG00000132879;
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; proteasomal protein catabolic process [GO:0010498]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H4M3-1; Sequence=Displayed; Name=2; IsoId=Q9H4M3-2; Sequence=VSP_011346, VSP_011347; 


uniprotID: Q96EF6
geneSymbol: FBXO17
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 17 (F-box only protein 26)
length: 278
go: ENSG00000269190;
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]


uniprotID: O94952
geneSymbol: FBXO21
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 21
length: 628
go: ENSG00000135108;
snps: rs11556202
sequence:

opentargets:
cytosol [GO:0005829]; ubiquitin ligase complex [GO:0000151]; DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O94952-2; Sequence=Displayed; Note=May be due to a competing acceptor splice site. No experimental confirmation available.; Name=2; IsoId=O94952-1; Sequence=VSP_035975; 


uniprotID: Q9BRP7
geneSymbol: FDXACB1
length: 624
go: ENSG00000255561;
snps: rs59164893 rs611010 rs3168263
name:
Ferredoxin-fold anticodon-binding domain-containing protein 1 (FDX-ACDB domain-containing protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; rRNA (uridine-N3-)-methyltransferase activity [GO:0070042]; rRNA base methylation [GO:0070475]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BRP7-1; Sequence=Displayed; Name=2; IsoId=Q9BRP7-2; Sequence=VSP_056997; Note=No experimental confirmation available.; 


uniprotID: Q9NQT5
geneSymbol: EXOSC3
reactome: R-HSA-380994;R-HSA-429958;R-HSA-450385;R-HSA-450513;R-HSA-450604;R-HSA-6791226;
pdb: 2NN6;6D6Q;6D6R;6H25;
name: Exosome complex component RRP40 (Exosome component 3) (Ribosomal RNA-processing protein 40) (p10)
length: 275
go: ENSG00000107371;
snps: rs387907196 rs374550999 rs141138948 rs387907195 rs3208406 rs672601332
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic exosome (RNase complex) [GO:0000177]; cytosol [GO:0005829]; exosome (RNase complex) [GO:0000178]; nuclear exosome (RNase complex) [GO:0000176]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptionally active chromatin [GO:0035327]; 3'-5'-exoribonuclease activity [GO:0000175]; RNA binding [GO:0003723]; CUT catabolic process [GO:0071034]; DNA deamination [GO:0045006]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000467]; isotype switching [GO:0045190]; nuclear polyadenylation-dependent rRNA catabolic process [GO:0071035]; nuclear polyadenylation-dependent tRNA catabolic process [GO:0071038]; nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription [GO:0071049]; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' [GO:0034427]; polyadenylation-dependent snoRNA 3'-end processing [GO:0071051]; positive regulation of isotype switching [GO:0045830]; regulation of mRNA stability [GO:0043488]; rRNA processing [GO:0006364]; U4 snRNA 3'-end processing [GO:0034475]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NQT5-1; Sequence=Displayed; Name=2; IsoId=Q9NQT5-2; Sequence=VSP_043457; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17545563}. Nucleus, nucleolus {ECO:0000269|PubMed:20531389}. Nucleus {ECO:0000269|PubMed:17545563}.


uniprotID: Q5JX69
geneSymbol: FAM209B
name: Protein FAM209B
length: 171
go: ENSG00000213714;
opentargets: integral component of membrane [GO:0016021]; nucleus [GO:0005634]
snps: rs3209183 rs61440263 rs2296129
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MWTLKSSLVLLLCLTCSYAFMFSSLRQKTSEPQGKVPCGEHFRIRQNLPEHTQGWLGSKWLWLLFAVVPFVILQCQRDSEKNKEQSPPGLRGFPFRTPLKKNQNASLYKDCVFNTLNELEVELLKFVSEVQNLKGAMATGSGSNLKLRRSEMPADPYHVTICKIWGEESSS


uniprotID: Q8IYI6
geneSymbol: EXOC8
reactome: R-HSA-1445148;R-HSA-264876;R-HSA-5620916;
name: Exocyst complex component 8 (Exocyst complex 84 kDa subunit)
length: 725
go: ENSG00000116903;
sequence:

opentargets:
cell leading edge [GO:0031252]; cytosol [GO:0005829]; exocyst [GO:0000145]; growth cone [GO:0030426]; late endosome [GO:0005770]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Ral GTPase binding [GO:0017160]; endosome organization [GO:0007032]; exocyst assembly [GO:0001927]; exocyst localization [GO:0051601]; extracellular matrix disassembly [GO:0022617]; protein transport [GO:0015031]; regulation of macroautophagy [GO:0016241]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54924}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection {ECO:0000250|UniProtKB:O54924}. Note=Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during neuronal differentiation (By similarity). Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Localizes at the leading edge of migrating cells (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O54924}.


uniprotID: H3BQW9
geneSymbol: FAM229A
name: Protein FAM229A
length: 127
go: ENSG00000225828;
sequence:
MLPSSTPGPGHATETCPAPPGPERSPAARAPAAASSLGPVSTAGRAPRGLDMSAQEPPQGRRFPIEAGDSRGLAAAPESQDSPEAVATEHNPVRPLRRCPGCHCLTLLHVPIDVYLAMGGSPRARAT


uniprotID: Q6SJ93
geneSymbol: FAM111B
name: Protein FAM111B (Cancer-associated nucleoprotein)
length: 734
go: ENSG00000189057;
snps: rs1060428 rs587777236 rs587777237 rs587777238 rs17153376
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6SJ93-1; Sequence=Displayed; Name=2; IsoId=Q6SJ93-2; Sequence=VSP_022739; 


uniprotID: A8MX19
geneSymbol: FAM90A12P
name: Putative protein FAM90A12P
length: 464
sequence:


uniprotID: Q6NSW5
geneSymbol: FAM45BP
name: Putative protein FAM45B
length: 357
sequence:


uniprotID: Q96MK3
geneSymbol: FAM20A
reactome: R-HSA-381426;R-HSA-8957275;
pdb: 5WRR;5WRS;5YH2;5YH3;
name: Pseudokinase FAM20A
length: 541
go: ENSG00000108950;
snps: rs981673034 rs2302234 rs377432171 rs2907373
sequence:

opentargets:
cell [GO:0005623]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; protein serine/threonine kinase activator activity [GO:0043539]; biomineral tissue development [GO:0031214]; calcium ion homeostasis [GO:0055074]; enamel mineralization [GO:0070166]; positive regulation of protein phosphorylation [GO:0001934]; protein phosphorylation [GO:0006468]; response to bacterium [GO:0009617]; tooth eruption [GO:0044691]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8CID3}. Golgi apparatus {ECO:0000269|PubMed:23468644}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8CID3}.


uniprotID: Q5TGI0
geneSymbol: FAXC
name: Failed axon connections homolog
length: 409
go: ENSG00000146267;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TGI0-1; Sequence=Displayed; Name=2; IsoId=Q5TGI0-2; Sequence=VSP_056994; Note=No experimental confirmation available.; 


uniprotID: Q6V0I7
geneSymbol: FAT4
length: 4981
go: ENSG00000196159;
name:
Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J)

sequence:

opentargets:
apical part of cell [GO:0045177]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; branching involved in ureteric bud morphogenesis [GO:0001658]; cerebral cortex development [GO:0021987]; condensed mesenchymal cell proliferation [GO:0072137]; digestive tract development [GO:0048565]; fibroblast growth factor receptor signaling pathway [GO:0008543]; heart morphogenesis [GO:0003007]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; hippo signaling [GO:0035329]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inner ear receptor cell stereocilium organization [GO:0060122]; neurogenesis [GO:0022008]; Notch signaling pathway [GO:0007219]; ossification involved in bone maturation [GO:0043931]; plasma membrane organization [GO:0007009]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]

snps:
rs6847454 rs1039808 rs398122955 rs12508222 rs1567047 rs17009684 rs12650153 rs398122953 rs199682210 rs11942361 rs398122954 rs1014867 rs17009858 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6V0I7-1; Sequence=Displayed; Name=2; IsoId=Q6V0I7-2; Sequence=VSP_032334, VSP_032335, VSP_032336, VSP_032337; Name=3; IsoId=Q6V0I7-3; Sequence=VSP_032338; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=In the kidney, localizes to primary cilia. {ECO:0000250}.


uniprotID: Q8WW38
geneSymbol: ZFPM2
reactome: R-HSA-983231;
length: 1151
go: ENSG00000169946;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23226341}.
name:
Zinc finger protein ZFPM2 (Friend of GATA protein 2) (FOG-2) (Friend of GATA 2) (hFOG-2) (Zinc finger protein 89B) (Zinc finger protein multitype 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II transcription factor binding [GO:0001085]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; zinc ion binding [GO:0008270]; blood coagulation [GO:0007596]; embryonic organ development [GO:0048568]; gonadal mesoderm development [GO:0007506]; heart development [GO:0007507]; in utero embryonic development [GO:0001701]; lung development [GO:0030324]; negative regulation of cell death [GO:0060548]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of female gonad development [GO:2000195]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; outflow tract septum morphogenesis [GO:0003148]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; right ventricular cardiac muscle tissue morphogenesis [GO:0003221]; vasculogenesis [GO:0001570]; ventricular septum morphogenesis [GO:0060412]

snps:
rs121908601 rs202204708 rs200834568 rs606231252 rs11993776 rs187043152 rs28374544 rs2920048 rs16873741 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WW38-1; Sequence=Displayed; Name=2; IsoId=Q8WW38-2; Sequence=VSP_009701, VSP_009702; Note=Sequence incomplete. No experimental confirmation available.; 


uniprotID: Q8NFZ0
geneSymbol: FBH1
name: F-box DNA helicase 1 (hFBH1) (EC 3.6.4.12) (F-box only protein 18)
length: 1043
go: ENSG00000134452;
sequence:

opentargets:
chromatin [GO:0000785]; nuclear SCF ubiquitin ligase complex [GO:0043224]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; 3'-5' DNA helicase activity [GO:0043138]; ATP binding [GO:0005524]; ATP-dependent 3'-5' DNA helicase activity [GO:0043140]; DNA helicase activity [GO:0003678]; DNA translocase activity [GO:0015616]; double-stranded DNA binding [GO:0003690]; single-stranded DNA binding [GO:0003697]; cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair via homologous recombination [GO:0000724]; negative regulation of chromatin binding [GO:0035562]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of protein phosphorylation [GO:0001934]; protein ubiquitination [GO:0016567]; replication fork processing [GO:0031297]; replication fork protection [GO:0048478]; response to intra-S DNA damage checkpoint signaling [GO:0072429]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NFZ0-1; Sequence=Displayed; Name=2; IsoId=Q8NFZ0-2; Sequence=VSP_037942; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}. Chromosome {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23319600, ECO:0000269|PubMed:23677613}. Note=Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed:23677613). {ECO:0000269|PubMed:19736316, ECO:0000269|PubMed:23677613}.


uniprotID: Q01362
geneSymbol: MS4A2
reactome: R-HSA-2454202;R-HSA-2730905;R-HSA-2871796;R-HSA-2871809;R-HSA-2871837;
length: 244
go: ENSG00000149534;
drug: DB00043;
snps: rs35033981 rs535630 rs569108
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
High affinity immunoglobulin epsilon receptor subunit beta (FcERI) (Fc epsilon receptor I beta-chain) (IgE Fc receptor subunit beta) (Membrane-spanning 4-domains subfamily A member 2)

sequence:

opentargets:
external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; IgE binding [GO:0019863]; Fc-epsilon receptor signaling pathway [GO:0038095]; immune response [GO:0006955]; inflammatory response [GO:0006954]


uniprotID: Q969U6
geneSymbol: FBXW5
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
name: F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
length: 566
go: ENSG00000159069;
snps: rs7850438
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21725316}.
sequence:

opentargets:
Cul4-RING E3 ubiquitin ligase complex [GO:0080008]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; protein kinase binding [GO:0019901]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic nuclear division [GO:0007088]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969U6-1; Sequence=Displayed; Name=2; IsoId=Q969U6-2; Sequence=VSP_009479, VSP_009480; 


uniprotID: Q9NRD1
geneSymbol: FBXO6
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
name: F-box only protein 6 (F-box protein that recognizes sugar chains 2) (F-box/G-domain protein 2)
length: 293
go: ENSG00000116663;
snps: rs3125818 rs2294639
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19716789}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum quality control compartment [GO:0044322]; SCF ubiquitin ligase complex [GO:0019005]; carbohydrate binding [GO:0030246]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; DNA damage checkpoint [GO:0000077]; DNA repair [GO:0006281]; glycoprotein catabolic process [GO:0006516]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; proteolysis [GO:0006508]; response to unfolded protein [GO:0006986]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent ERAD pathway [GO:0030433]


uniprotID: Q9NWN3
geneSymbol: FBXO34
name: F-box only protein 34
length: 711
go: ENSG00000178974;
snps: rs35070799 rs1045002 rs3742569 rs10138395
sequence:


uniprotID: Q9UH90
geneSymbol: FBXO40
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 40 (Muscle disease-related protein)
length: 709
go: ENSG00000163833;
snps: rs4676684
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; muscle cell differentiation [GO:0042692]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]


uniprotID: P37268
geneSymbol: FDFT1
reactome: R-HSA-191273;R-HSA-1989781;R-HSA-2426168;
length: 417
go: ENSG00000079459;
drug: DB05317;
snps: rs4731 rs1804473
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
pdb:
1EZF;3ASX;3LEE;3Q2Z;3Q30;3V66;3VJ8;3VJ9;3VJA;3VJB;3VJC;3WC9;3WCD;3WCF;3WCH;3WCI;3WCJ;3WCL;3WCM;3WEF;3WEG;3WEH;3WEI;3WEJ;3WEK;3WSA;

name:
Squalene synthase (SQS) (SS) (EC 2.5.1.21) (FPP:FPP farnesyltransferase) (Farnesyl-diphosphate farnesyltransferase)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; farnesyl-diphosphate farnesyltransferase activity [GO:0004310]; squalene synthase activity [GO:0051996]; cholesterol biosynthetic process [GO:0006695]; ergosterol biosynthetic process [GO:0006696]; farnesyl diphosphate metabolic process [GO:0045338]; isoprenoid biosynthetic process [GO:0008299]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of lipid metabolic process [GO:0019216]; steroid biosynthetic process [GO:0006694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P37268-1; Sequence=Displayed; Name=2; IsoId=P37268-2; Sequence=VSP_056283; Note=No experimental confirmation available.; Name=3; IsoId=P37268-3; Sequence=VSP_056282; Note=No experimental confirmation available.; Name=4; IsoId=P37268-4; Sequence=VSP_056517; Note=No experimental confirmation available.; Name=5; IsoId=P37268-5; Sequence=VSP_056518; Note=No experimental confirmation available.; 


uniprotID: Q8NEZ5
geneSymbol: FBXO22
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 22 (F-box protein FBX22p44)
length: 403
go: ENSG00000167196;
location: SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; Z disc [GO:0030018]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein modification process [GO:0006464]; cellular response to starvation [GO:0009267]; nucleocytoplasmic transport [GO:0006913]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; regulation of skeletal muscle fiber development [GO:0048742]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NEZ5-1; Sequence=Displayed; Name=2; IsoId=Q8NEZ5-2; Sequence=VSP_041821; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q8NEZ5-3; Sequence=VSP_013058, VSP_013059; Note=No experimental confirmation available.; 


uniprotID: P24071
geneSymbol: FCAR
reactome: R-HSA-6798695;
pdb: 1OVZ;1OW0;1UCT;
name: Immunoglobulin alpha Fc receptor (IgA Fc receptor) (CD antigen CD89)
length: 287
go: ENSG00000186431;
snps: rs11666735 rs16986050
sequence:

opentargets:
extracellular region [GO:0005576]; ficolin-1-rich granule membrane [GO:0101003]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; IgA binding [GO:0019862]; IgA receptor activity [GO:0019766]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-6 [GO:0071354]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to tumor necrosis factor [GO:0071356]; Fc receptor signaling pathway [GO:0038093]; immune response [GO:0006955]; neutrophil activation [GO:0042119]; neutrophil degranulation [GO:0043312]; neutrophil mediated immunity [GO:0002446]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of oxidative stress-induced cell death [GO:1903209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=11;  Comment=Additional isoforms seem to exist.; Name=A.1; IsoId=P24071-1; Sequence=Displayed; Name=A.2; IsoId=P24071-2; Sequence=VSP_002635; Name=A.3; Synonyms=RLA2; IsoId=P24071-3; Sequence=VSP_002634; Name=B; IsoId=P24071-4; Sequence=VSP_002636; Name=B-delta-S2; IsoId=P24071-5; Sequence=VSP_002632, VSP_002636; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=U02; IsoId=P24071-6; Sequence=VSP_002633, VSP_002635; Name=L10; IsoId=P24071-7; Sequence=VSP_002632, VSP_043565; Name=U09; IsoId=P24071-8; Sequence=VSP_002632, VSP_043567; Name=U10; IsoId=P24071-9; Sequence=VSP_002632, VSP_043566; Name=U11; IsoId=P24071-10; Sequence=VSP_002632; Name=U13; IsoId=P24071-11; Sequence=VSP_002632, VSP_002635; 

location:
SUBCELLULAR LOCATION: Isoform A.1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform A.2: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform A.3: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform B: Secreted.; SUBCELLULAR LOCATION: Isoform B-delta-S2: Secreted.


uniprotID: Q0JRZ9
geneSymbol: FCHO2
reactome: R-HSA-8856825;R-HSA-8856828;
pdb: 2V0O;
name: F-BAR domain only protein 2
length: 810
go: ENSG00000157107;
snps: rs185435
sequence:

opentargets:
AP-2 adaptor complex [GO:0030122]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic endocytic zone membrane [GO:0098835]; cytoskeletal protein binding [GO:0008092]; identical protein binding [GO:0042802]; microtubule binding [GO:0008017]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylserine binding [GO:0001786]; phospholipid binding [GO:0005543]; tubulin binding [GO:0015631]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; membrane invagination [GO:0010324]; membrane organization [GO:0061024]; plasma membrane tubulation [GO:0097320]; protein localization to plasma membrane [GO:0072659]; synaptic vesicle endocytosis [GO:0048488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q0JRZ9-1; Sequence=Displayed; Name=2; IsoId=Q0JRZ9-2; Sequence=VSP_021910, VSP_021911; Note=No experimental confirmation available.; Name=3; IsoId=Q0JRZ9-3; Sequence=VSP_044812; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity). {ECO:0000250}.


uniprotID: A5D6W6
geneSymbol: FITM1
reactome: R-HSA-8964572;
name: Fat storage-inducing transmembrane protein 1 (Fat-inducing protein 1)
length: 292
go: ENSG00000139914;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; lipid droplet organization [GO:0034389]; lipid storage [GO:0019915]; phospholipid biosynthetic process [GO:0008654]; positive regulation of sequestering of triglyceride [GO:0010890]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A5D6W6-1; Sequence=Displayed; Name=2; IsoId=A5D6W6-2; Sequence=VSP_031493; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18160536}; Multi-pass membrane protein {ECO:0000269|PubMed:18160536}.


uniprotID: Q14318
geneSymbol: FKBP8
reactome: R-HSA-5689880;
pdb: 2AWG;2D9F;2F2D;2MF9;3EY6;5MGX;
length: 412
go: ENSG00000105701;
snps: rs11574806
name:
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; integral component of endoplasmic reticulum membrane [GO:0030176]; membrane [GO:0016020]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; disordered domain specific binding [GO:0097718]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; apoptotic process [GO:0006915]; camera-type eye development [GO:0043010]; cell fate specification [GO:0001708]; dorsal/ventral neural tube patterning [GO:0021904]; intracellular signal transduction [GO:0035556]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of protein phosphorylation [GO:0001933]; positive regulation of BMP signaling pathway [GO:0030513]; smoothened signaling pathway [GO:0007224]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q14318-1; Sequence=Displayed; Name=2; IsoId=Q14318-2; Sequence=VSP_034486; Name=3; IsoId=Q14318-3; Sequence=VSP_047717; Note=Interacts with BCL2L1/BCLX.; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16176796}. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 1: Mitochondrion membrane {ECO:0000269|PubMed:12510191, ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Mitochondrion membrane {ECO:0000269|PubMed:18385096}; Single-pass membrane protein; Cytoplasmic side {ECO:0000305}.


uniprotID: Q15007
geneSymbol: WTAP
reactome: R-HSA-72203;
length: 396
go: ENSG00000146457;
snps: rs35059844
name:
Pre-mRNA-splicing regulator WTAP (Female-lethal(2)D homolog) (hFL(2)D) (WT1-associated protein) (Wilms tumor 1-associating protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; cell cycle [GO:0007049]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15007-1; Sequence=Displayed; Name=2; IsoId=Q15007-2; Sequence=VSP_010278, VSP_010279; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:24407421}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11001926, ECO:0000269|PubMed:24316715, ECO:0000269|PubMed:26458103}. Cytoplasm {ECO:0000250|UniProtKB:Q9ER69}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:Q9ER69}.


uniprotID: Q7Z6J4
geneSymbol: FGD2
reactome: R-HSA-193648;R-HSA-194840;R-HSA-416482;
name: FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)
length: 655
go: ENSG00000146192;
snps: rs831510
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; lamellipodium [GO:0030027]; nucleus [GO:0005634]; ruffle [GO:0001726]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphatidylinositol phosphate binding [GO:1901981]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; small GTPase binding [GO:0031267]; actin cytoskeleton organization [GO:0030036]; cytoskeleton organization [GO:0007010]; filopodium assembly [GO:0046847]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JUN kinase activity [GO:0043507]; regulation of cell shape [GO:0008360]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q7Z6J4-1; Sequence=Displayed; Name=2; IsoId=Q7Z6J4-2; Sequence=VSP_013065, VSP_013070, VSP_013072; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z6J4-4; Sequence=VSP_013066, VSP_013071; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z6J4-5; Sequence=VSP_013067, VSP_013068, VSP_038219; Note=May be due to an intron retention. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Early endosome {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. {ECO:0000250}.


uniprotID: A6NFU0
geneSymbol: FAM187A
name: Ig-like V-type domain-containing protein FAM187A
length: 413
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q93063
geneSymbol: EXT2
reactome: R-HSA-2022928;R-HSA-3656237;R-HSA-3656253;
length: 718
go: ENSG00000151348;
snps: rs4755779 rs140075817 rs376292686 rs771803942 rs764379119 rs121918280 rs373582542
name:
Exostosin-2 (EC 2.4.1.224) (EC 2.4.1.225) (Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Multiple exostoses protein 2) (Putative tumor suppressor protein EXT2)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; UDP-N-acetylglucosamine transferase complex [GO:0043541]; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity [GO:0050508]; glucuronosyltransferase activity [GO:0015020]; heparan sulfate N-acetylglucosaminyltransferase activity [GO:0042328]; metal ion binding [GO:0046872]; N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity [GO:0050509]; protein heterodimerization activity [GO:0046982]; transferase activity, transferring glycosyl groups [GO:0016757]; cell differentiation [GO:0030154]; cellular polysaccharide biosynthetic process [GO:0033692]; glycosaminoglycan biosynthetic process [GO:0006024]; heparan sulfate proteoglycan biosynthetic process [GO:0015012]; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process [GO:0015014]; mesoderm formation [GO:0001707]; ossification [GO:0001503]; protein glycosylation [GO:0006486]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q93063-1; Sequence=Displayed; Name=2; IsoId=Q93063-2; Sequence=VSP_001798; Name=3; IsoId=Q93063-3; Sequence=VSP_046053; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Golgi apparatus membrane {ECO:0000269|PubMed:10679296}; Single-pass type II membrane protein {ECO:0000269|PubMed:10679296}. Note=The EXT1/EXT2 complex is localized in the Golgi apparatus.


uniprotID: A6NFZ4
geneSymbol: FAM24A
name: Protein FAM24A
length: 105
go: ENSG00000203795;
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MAKMFDLRTKIMIGIGSSLLVAAMVLLSVVFCLYFKVAKALKAAKDPDAVAVKNHNPDKVCWATNSQAKATTMESCPSLQCCEGCRMHASSDSLPPCCCDINEGL


uniprotID: P0DMU4
geneSymbol: FAM231AP
name: Putative protein FAM231AP
length: 169
sequence:
MVSSKGLWKERPSAHTSECFSTTACPVAFILLVWNSQTPAGLQSLCTGRHPSLSARAQRAGPRASREEGTFWTERVGQERWLIRSGSSQNESQEDQGAGLISQAGLKADNRRESSTWANEVEDRRPQCTPALNLTPSHPHPPHSLTTFLRSVIGIQIPPGLVAAGGTVA


uniprotID: Q6P1L5
geneSymbol: FAM117B
name: Protein FAM117B (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein)
length: 589
go: ENSG00000138439;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P1L5-1; Sequence=Displayed; Name=2; IsoId=Q6P1L5-2; Sequence=VSP_027729, VSP_027730; Note=No experimental confirmation available.; 


uniprotID: Q9Y256
geneSymbol: RCE1
reactome: R-HSA-5689880;
length: 329
go: ENSG00000173653;
name:
CAAX prenyl protease 2 (EC 3.4.22.-) (Farnesylated proteins-converting enzyme 2) (FACE-2) (Prenyl protein-specific endoprotease 2) (RCE1 homolog) (hRCE1)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; cysteine-type endopeptidase activity [GO:0004197]; endopeptidase activity [GO:0004175]; metalloendopeptidase activity [GO:0004222]; CAAX-box protein processing [GO:0071586]; protein deubiquitination [GO:0016579]; proteolysis [GO:0006508]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19188362}; Multi-pass membrane protein {ECO:0000269|PubMed:19188362}.


uniprotID: O95864
geneSymbol: FADS2
reactome: R-HSA-2046105;R-HSA-2046106;
length: 444
go: ENSG00000134824;
drug: DB00132;
name:
Fatty acid desaturase 2 (EC 1.14.19.3) (Acyl-CoA 6-desaturase) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; linoleoyl-CoA desaturase activity [GO:0016213]; stearoyl-CoA 9-desaturase activity [GO:0004768]; alpha-linolenic acid metabolic process [GO:0036109]; linoleic acid metabolic process [GO:0043651]; unsaturated fatty acid biosynthetic process [GO:0006636]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O95864-1; Sequence=Displayed; Name=2; IsoId=O95864-2; Sequence=VSP_028568; Name=3; IsoId=O95864-3; Sequence=VSP_028569; Note=No experimental confirmation available.; Name=4; IsoId=O95864-4; Sequence=VSP_054809; 


uniprotID: P58499
geneSymbol: FAM3B
name: Protein FAM3B (Cytokine-like protein 2-21) (Pancreatic-derived factor) (PANDER)
length: 235
go: ENSG00000183844;
snps: rs2838012
sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; cytokine activity [GO:0005125]; apoptotic process [GO:0006915]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=B; IsoId=P58499-1; Sequence=Displayed; Name=A; IsoId=P58499-2; Sequence=VSP_001504; Name=C; IsoId=P58499-3; Sequence=VSP_001505; 

location:
SUBCELLULAR LOCATION: Secreted. Note=Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.


uniprotID: Q9NVI1
geneSymbol: FANCI
reactome: R-HSA-6783310;R-HSA-6796648;
name: Fanconi anemia group I protein (Protein FACI)
length: 1328
go: ENSG00000140525;
snps: rs62020347 rs17803620 rs28378332 rs2283432 rs121918163
sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA polymerase binding [GO:0070182]; cell cycle [GO:0007049]; interstrand cross-link repair [GO:0036297]; positive regulation of protein ubiquitination [GO:0031398]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=3; IsoId=Q9NVI1-3; Sequence=Displayed; Name=2; IsoId=Q9NVI1-2; Sequence=VSP_026069, VSP_020257; Name=1; IsoId=Q9NVI1-1; Sequence=VSP_026069; Name=4; IsoId=Q9NVI1-4; Sequence=VSP_035606; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17412408, ECO:0000269|PubMed:17460694, ECO:0000269|PubMed:19465922}. Note=Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.


uniprotID: Q8IYD8
geneSymbol: FANCM
reactome: R-HSA-6783310;
pdb: 4BXO;4DAY;4DRB;4E45;4M6W;
length: 2048
go: ENSG00000187790;
snps: rs10138997 rs45547534 rs1367580 rs3736772
name:
Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)

sequence:

opentargets:
FANCM-MHF complex [GO:0071821]; Fanconi anaemia nuclear complex [GO:0043240]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; nuclease activity [GO:0004518]; interstrand cross-link repair [GO:0036297]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IYD8-1; Sequence=Displayed; Name=2; IsoId=Q8IYD8-2; Sequence=VSP_015989, VSP_015990; Name=3; IsoId=Q8IYD8-3; Sequence=VSP_054504; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16116422, ECO:0000269|PubMed:20347428, ECO:0000269|PubMed:20347429}.


uniprotID: Q969F0
geneSymbol: FATE1
length: 183
go: ENSG00000147378;
snps: rs3810715 rs141497002
name:
Fetal and adult testis-expressed transcript protein (Cancer/testis antigen 43) (CT43) (Tumor antigen BJ-HCC-2)

sequence:
MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRSRGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYAGNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRHRETLIIAVLVSASIANLWLWMNQ

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; Mitochondria-associated ER Membrane [GO:0044233]; mitochondrial outer membrane [GO:0005741]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; negative regulation of mitochondrial calcium ion concentration [GO:0051562]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26567849, ECO:0000269|PubMed:27402544}. Mitochondrion outer membrane {ECO:0000269|PubMed:27402544}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27402544}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:27402544}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. {ECO:0000269|PubMed:27402544}.


uniprotID: Q9NYY8
geneSymbol: FASTKD2
name: FAST kinase domain-containing protein 2, mitochondrial
length: 710
go: ENSG00000118246;
snps: rs3762568 rs13003768
sequence:

opentargets:
intercellular bridge [GO:0045171]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; cellular respiration [GO:0045333]; mitochondrial large ribosomal subunit assembly [GO:1902775]; positive regulation of mitochondrial translation [GO:0070131]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NYY8-1; Sequence=Displayed; Name=2; IsoId=Q9NYY8-2; Sequence=VSP_017186, VSP_017187; 

location:
SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:25683715}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:25683715}.


uniprotID: P49327
geneSymbol: FASN
reactome: R-HSA-163765;R-HSA-199220;R-HSA-2426168;R-HSA-75105;
pdb: 1XKT;2CG5;2JFD;2JFK;2PX6;3HHD;3TJM;4PIV;4W82;4W9N;4Z49;5C37;
length: 2511
go: ENSG00000169710;
drug: DB01034;DB01083;
snps: rs113931914 rs2228305 rs561903908 rs2228307
name:
Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)]

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glycogen granule [GO:0042587]; Golgi apparatus [GO:0005794]; melanosome [GO:0042470]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity [GO:0047451]; 3-oxo-glutaryl-[acp] methyl ester reductase activity [GO:0102131]; 3-oxo-pimeloyl-[acp] methyl ester reductase activity [GO:0102132]; 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [GO:0004316]; 3-oxoacyl-[acyl-carrier-protein] synthase activity [GO:0004315]; [acyl-carrier-protein] S-acetyltransferase activity [GO:0004313]; [acyl-carrier-protein] S-malonyltransferase activity [GO:0004314]; cadherin binding [GO:0045296]; drug binding [GO:0008144]; enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity [GO:0047117]; fatty acid synthase activity [GO:0004312]; myristoyl-[acyl-carrier-protein] hydrolase activity [GO:0016295]; NADPH binding [GO:0070402]; oleoyl-[acyl-carrier-protein] hydrolase activity [GO:0004320]; palmitoyl-[acyl-carrier-protein] hydrolase activity [GO:0016296]; phosphopantetheine binding [GO:0031177]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; acetyl-CoA metabolic process [GO:0006084]; cellular response to interleukin-4 [GO:0071353]; establishment of endothelial intestinal barrier [GO:0090557]; ether lipid biosynthetic process [GO:0008611]; fatty acid biosynthetic process [GO:0006633]; fatty acid metabolic process [GO:0006631]; fatty-acyl-CoA biosynthetic process [GO:0046949]; macromolecule metabolic process [GO:0043170]; mammary gland development [GO:0030879]; monocyte differentiation [GO:0030224]; neutrophil differentiation [GO:0030223]; osteoblast differentiation [GO:0001649]; positive regulation of cellular metabolic process [GO:0031325]; regulation of cholesterol biosynthetic process [GO:0045540]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.


uniprotID: Q14CZ7
geneSymbol: FASTKD3
name: FAST kinase domain-containing protein 3, mitochondrial
length: 662
go: ENSG00000124279;
snps: rs3733782 rs2966952 rs16879259
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:27789713}.
sequence:

opentargets:
mitochondrion [GO:0005739]; nucleus [GO:0005634]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; cellular respiration [GO:0045333]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; positive regulation of mitochondrial translation [GO:0070131]; regulation of mitochondrial mRNA stability [GO:0044528]


uniprotID: P35555
geneSymbol: FBN1
reactome: R-HSA-1474228;R-HSA-1566948;R-HSA-2129379;R-HSA-216083;R-HSA-381426;R-HSA-8957275;
pdb: 1APJ;1EMN;1EMO;1LMJ;1UZJ;1UZK;1UZP;1UZQ;2M74;2W86;5MS9;
name: Fibrillin-1 [Cleaved into: Asprosin]
length: 2871
sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; microfibril [GO:0001527]; calcium ion binding [GO:0005509]; extracellular matrix constituent conferring elasticity [GO:0030023]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; hormone activity [GO:0005179]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein-containing complex binding [GO:0044877]; activation of protein kinase A activity [GO:0034199]; camera-type eye development [GO:0043010]; cell adhesion mediated by integrin [GO:0033627]; cellular protein metabolic process [GO:0044267]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic eye morphogenesis [GO:0048048]; extracellular matrix organization [GO:0030198]; glucose homeostasis [GO:0042593]; glucose metabolic process [GO:0006006]; heart development [GO:0007507]; metanephros development [GO:0001656]; negative regulation of osteoclast development [GO:2001205]; negative regulation of osteoclast differentiation [GO:0045671]; post-embryonic eye morphogenesis [GO:0048050]; post-translational protein modification [GO:0043687]; protein kinase A signaling [GO:0010737]; sequestering of BMP in extracellular matrix [GO:0035582]; sequestering of TGFbeta in extracellular matrix [GO:0035583]; skeletal system development [GO:0001501]

snps:
rs25397 rs25403 rs112660651 rs137854467 rs363850 rs363853 rs137854480 rs12324002 rs363855 rs4775765 rs137854462 rs140603 rs137854463 rs137854477 rs140592 rs140593 rs137854472 rs2229324 rs137854478 rs137854465 rs140597 rs137854470 rs137854468 rs137854482 rs137854473 rs137854456 rs140598 rs140599 rs137854475 rs137854469 rs137854471 rs137854458 rs137854474 rs140647 rs112375043 rs61730054 rs111401431 rs137854459 rs140627 rs111929350 rs112728248 rs363802 rs363804 rs363805 rs200816828 rs363815 rs363816 rs137854461 rs363821 rs137854460 rs112836174 rs363835 rs137854457 rs111588631 rs363831 rs137854464 rs113544411 rs111984349 rs141133182 rs61746008 rs113722038 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24982166}. Note=Fibrillin-1 and Asprosin chains are still linked together during the secretion from cells, but are subsequently separated by furin (PubMed:24982166). {ECO:0000269|PubMed:24982166}.; SUBCELLULAR LOCATION: Asprosin: Secreted {ECO:0000269|PubMed:27087445}. Note=Secreted into the plasma. {ECO:0000269|PubMed:27087445}.; SUBCELLULAR LOCATION: Fibrillin-1: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11461921, ECO:0000269|PubMed:24982166}.


uniprotID: Q2M3D2
geneSymbol: EXOC3L2
length: 409
go: ENSG00000283632;
snps: rs10411314
name:
Exocyst complex component 3-like protein 2 (HBV X-transactivated gene 7 protein) (HBV XAg-transactivated protein 7)

sequence:

opentargets:
exocyst [GO:0000145]; SNARE binding [GO:0000149]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]


uniprotID: Q9NYK6
geneSymbol: EURL
name: Protein EURL homolog
length: 297
go: ENSG00000154642;
snps: rs2824495 rs1047976 rs1047978 rs8128004 rs2824494
sequence:

opentargets:
cerebral cortex neuron differentiation [GO:0021895]; positive regulation of dendritic spine development [GO:0060999]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NYK6-1; Sequence=Displayed; Name=2; IsoId=Q9NYK6-2; Sequence=VSP_036451; Name=3; IsoId=Q9NYK6-3; Sequence=VSP_036452; 


uniprotID: Q9NYF3
geneSymbol: FAM53C
name: Protein FAM53C
length: 392
go: ENSG00000120709;
snps: rs35360938
sequence:


uniprotID: B1AL88
geneSymbol: FAM155A
name: Transmembrane protein FAM155A
length: 458
go: ENSG00000204442;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; calcium ion import across plasma membrane [GO:0098703]


uniprotID: Q9BTA0
geneSymbol: FAM167B
name: Protein FAM167B
length: 163
go: ENSG00000183615;
sequence:
MSLGLLKFQAVGEEDEEDEEGESLDSVKALTAKLQLQTRRPSYLEWTAQVQSQAWRRAQAKPGPGGPGDICGFDSMDSALEWLRRELREMQAQDRQLAGQLLRLRAQLHRLKMDQACHLHQELLDEAELELELEPGAGLALAPLLRHLGLTRMNISARRFTLC


uniprotID: Q9H8W3
geneSymbol: FAM204A
name: Protein FAM204A
length: 233
go: ENSG00000165669;
sequence:


uniprotID: Q8N2R8
geneSymbol: FAM43A
name: Protein FAM43A
length: 423
go: ENSG00000185112;
sequence:


uniprotID: Q6L9T8
geneSymbol: FAM72D
name: Protein FAM72D (Gastric cancer up-regulated protein 2)
length: 149
go: ENSG00000215784;
opentargets: cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]
sequence:
MSTNICSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFTGRCYFTKICKCKLKDIACLKCGNIVGYHVIVPCSSCLLSCNNRHFWMFHSQAVYDINRLDSTGVNVLLRGNLPEIEESTDEDVLNISAEECIR


uniprotID: P49640
geneSymbol: EVX1
name: Homeobox even-skipped homolog protein 1 (EVX-1)
length: 407
go: ENSG00000106038;
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; embryo development ending in birth or egg hatching [GO:0009792]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification [GO:0021913]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P49640-1; Sequence=Displayed; Name=2; IsoId=P49640-2; Sequence=VSP_056502; Note=No experimental confirmation available.; 


uniprotID: Q8IZU1
geneSymbol: FAM9A
name: Protein FAM9A
length: 332
go: ENSG00000183304;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12213195}.
sequence:

opentargets:
nucleolus [GO:0005730]; synaptonemal complex [GO:0000795]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]


uniprotID: Q7L8L6
geneSymbol: FASTKD5
name: FAST kinase domain-containing protein 5, mitochondrial
length: 764
go: ENSG00000215251;
snps: rs3746700 rs2422857 rs3746699
sequence:

opentargets:
mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; ribonucleoprotein granule [GO:0035770]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; cellular respiration [GO:0045333]; mitochondrial RNA processing [GO:0000963]; mRNA processing [GO:0006397]

location:
SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:20869947, ECO:0000269|PubMed:25683715}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:25683715}.


uniprotID: Q8TDW7
geneSymbol: FAT3
name: Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3)
length: 4557
go: ENSG00000165323;
snps: rs10830902 rs16917409 rs11821058 rs7949157 rs16918105 rs17615477 rs3847531 rs10765565 rs4753069
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; multicellular organism development [GO:0007275]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TDW7-3; Sequence=Displayed; Name=3; IsoId=Q8TDW7-1; Sequence=VSP_059739; Name=2; IsoId=Q8TDW7-2; Sequence=VSP_059761; Note=No experimental confirmation available.; 


uniprotID: Q96DP5
geneSymbol: MTFMT
reactome: R-HSA-5368286;
name: Methionyl-tRNA formyltransferase, mitochondrial (MtFMT) (EC 2.1.2.9)
length: 389
go: ENSG00000103707;
drug: DB00116;
snps: rs2946655 rs397514614 rs201431517
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
sequence:

opentargets:
mitochondrion [GO:0005739]; methionyl-tRNA formyltransferase activity [GO:0004479]; conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [GO:0071951]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96DP5-1; Sequence=Displayed; Name=2; IsoId=Q96DP5-2; Sequence=VSP_057059, VSP_057060; Note=No experimental confirmation available.; 


uniprotID: Q5VW36
geneSymbol: FOCAD
name: Focadhesin
length: 1801
opentargets: focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]
snps: rs10511687 rs10441706 rs17832431 rs7875872 rs10964742 rs3206852 rs3206852 rs3206852 rs4977881
sequence:

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, focal adhesion. Note=Colocalizes with VCL in astrocytes.


uniprotID: Q8IX07
geneSymbol: ZFPM1
reactome: R-HSA-8936459;R-HSA-983231;
pdb: 2XU7;
length: 1006
go: ENSG00000179588;
snps: rs34916016
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
Zinc finger protein ZFPM1 (Friend of GATA protein 1) (FOG-1) (Friend of GATA 1) (Zinc finger protein 89A) (Zinc finger protein multitype 1)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; transcriptional repressor complex [GO:0017053]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II activating transcription factor binding [GO:0001102]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; transcription factor binding [GO:0008134]; atrial septum morphogenesis [GO:0060413]; atrioventricular valve morphogenesis [GO:0003181]; blood coagulation [GO:0007596]; cardiac muscle tissue morphogenesis [GO:0055008]; definitive erythrocyte differentiation [GO:0060318]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; granulocyte differentiation [GO:0030851]; heart development [GO:0007507]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; mitral valve formation [GO:0003192]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of interleukin-4 biosynthetic process [GO:0045403]; negative regulation of mast cell differentiation [GO:0060377]; negative regulation of protein binding [GO:0032091]; negative regulation of transcription by RNA polymerase II [GO:0000122]; outflow tract morphogenesis [GO:0003151]; platelet formation [GO:0030220]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; primitive erythrocyte differentiation [GO:0060319]; regulation of chemokine production [GO:0032642]; regulation of definitive erythrocyte differentiation [GO:0010724]; regulation of megakaryocyte differentiation [GO:0045652]; T-helper cell lineage commitment [GO:0002295]; transcriptional activation by promoter-enhancer looping [GO:0071733]; tricuspid valve formation [GO:0003195]; ventricular septum morphogenesis [GO:0060412]


uniprotID: Q8N539
geneSymbol: FIBCD1
pdb: 4M7F;4M7H;
name: Fibrinogen C domain-containing protein 1
length: 461
go: ENSG00000130720;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; membrane [GO:0016020]; chitin binding [GO:0008061]; metal ion binding [GO:0046872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N539-1; Sequence=Displayed; Name=2; IsoId=Q8N539-2; Sequence=VSP_026618, VSP_026619, VSP_026620; 


uniprotID: Q9UJT9
geneSymbol: FBXL7
reactome: R-HSA-8854050;R-HSA-8951664;R-HSA-983168;
name: F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein 7) (F-box protein FBL6/FBL7)
length: 491
go: ENSG00000183580;
sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; cell division [GO:0051301]; cell proliferation [GO:0008283]; G2/M transition of mitotic cell cycle [GO:0000086]; mitotic cell cycle [GO:0000278]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; SCF complex assembly [GO:0010265]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UJT9-1; Sequence=Displayed; Name=2; IsoId=Q9UJT9-2; Sequence=VSP_054751; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to the centrosome during spindle formation. {ECO:0000250}.


uniprotID: Q5XX13
geneSymbol: FBXW10
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
length: 1052
go: ENSG00000171931;
snps: rs11544711 rs7209610 rs1026259
name:
F-box/WD repeat-containing protein 10 (F-box and WD-40 domain-containing protein 10) (Ubiquitin ligase-specificity factor)

sequence:

opentargets:
cytosol [GO:0005829]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5XX13-1; Sequence=Displayed; Name=2; IsoId=Q5XX13-2; Sequence=VSP_030727, VSP_030729; Note=No experimental confirmation available.; Name=3; IsoId=Q5XX13-3; Sequence=VSP_030728; Note=No experimental confirmation available.; Name=4; IsoId=Q5XX13-4; Sequence=VSP_039178; Note=No experimental confirmation available.; 


uniprotID: Q8TB52
geneSymbol: FBXO30
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 2YRE;
name: F-box only protein 30
length: 745
go: ENSG00000118496;
snps: rs9373475 rs17075385 rs3811102
sequence:

opentargets:
cytosol [GO:0005829]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]


uniprotID: Q8WUP2
geneSymbol: FBLIM1
reactome: R-HSA-446353;
pdb: 2K9U;2W0P;4P3W;
length: 373
go: ENSG00000162458;
snps: rs34375304 rs10927851
name:
Filamin-binding LIM protein 1 (FBLP-1) (Migfilin) (Mitogen-inducible 2-interacting protein) (MIG2-interacting protein)

sequence:

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; focal adhesion [GO:0005925]; stress fiber [GO:0001725]; filamin binding [GO:0031005]; metal ion binding [GO:0046872]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; regulation of cell shape [GO:0008360]; regulation of integrin activation [GO:0033623]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=FBLP-1A; IsoId=Q8WUP2-1; Sequence=Displayed; Name=2; Synonyms=FBLP-1; IsoId=Q8WUP2-2; Sequence=VSP_008782; Note=May be due to competing donor splice site.; Name=3; Synonyms=FBLP-1B; IsoId=Q8WUP2-3; Sequence=VSP_008781; Note=May be due to exon skipping.; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2 (PubMed:12679033). Isoform 2 is localized at actin stress fibers (PubMed:12496242). {ECO:0000269|PubMed:12496242, ECO:0000269|PubMed:12679033, ECO:0000269|PubMed:18829455}.


uniprotID: Q969P5
geneSymbol: FBXO32
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 32 (Atrogin-1) (Muscle atrophy F-box protein) (MAFbx)
length: 355
go: ENSG00000156804;
snps: rs6988591 rs11786471 rs771939133
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SCF ubiquitin ligase complex [GO:0019005]; Z disc [GO:0030018]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to dexamethasone stimulus [GO:0071549]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to denervation involved in regulation of muscle adaptation [GO:0014894]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969P5-1; Sequence=Displayed; Name=2; IsoId=Q969P5-2; Sequence=VSP_042744; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22249105, ECO:0000269|PubMed:26768247}. Nucleus {ECO:0000269|PubMed:22249105}. Note=Shuttles between cytoplasm and the nucleus.


uniprotID: Q6PIJ6
geneSymbol: FBXO38
name: F-box only protein 38 (Modulator of KLF7 activity homolog) (MoKA)
length: 1188
go: ENSG00000145868;
snps: rs398122838 rs10043775 rs11949133
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; positive regulation of neuron projection development [GO:0010976]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6PIJ6-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q6PIJ6-2; Sequence=VSP_011449; Name=3; IsoId=Q6PIJ6-3; Sequence=VSP_011448, VSP_011449; 


uniprotID: Q5T8I3
geneSymbol: FAM102B
name: Protein FAM102B
length: 360
go: ENSG00000162636;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T8I3-1; Sequence=Displayed; Name=2; IsoId=Q5T8I3-2; Sequence=VSP_034833; Note=No experimental confirmation available.; 


uniprotID: Q63HN1
geneSymbol: FAM205BP
name: Putative protein FAM205B
length: 556
snps: rs521552 rs524512
sequence:


uniprotID: P0C7V4
geneSymbol: FAM90A15P
name: Putative protein FAM90A15P
length: 464
sequence:


uniprotID: Q6P4D5
geneSymbol: FAM122C
name: Protein FAM122C
length: 195
go: ENSG00000156500;
sequence:
MAQEKMKLGFKSLPSSTTADGNILRRVNSAPLINGLGFNSQVLQADMLRIRTNRTTFRNRRSLLLPPPPFHGSISRLHQIKQEEAMDLINRETMSEWKLQSEIQISHSWEEGLKLVKWHFNINQKRFSKAQPTCFLLILPNCQKIMCIYFQLLLMETTAMLDLLVIRQLKSALSQTLLCHLLILVLICSSRQTFN

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6P4D5-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q6P4D5-2; Sequence=VSP_021222; Note=No experimental confirmation available.; Name=3; IsoId=Q6P4D5-3; Sequence=VSP_044990, VSP_044991, VSP_044992; Note=No experimental confirmation available.; 


uniprotID: Q9H5Z6
geneSymbol: FAM124B
name: Protein FAM124B
length: 455
go: ENSG00000124019;
opentargets: mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]
snps: rs3738954
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23285124}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H5Z6-1; Sequence=Displayed; Name=2; IsoId=Q9H5Z6-2; Sequence=VSP_025042, VSP_025043; 


uniprotID: Q7Z5A7
geneSymbol: FAM19A5
name: Protein FAM19A5 (Chemokine-like protein TAFA-5)
length: 132
go: ENSG00000219438;
opentargets: extracellular region [GO:0005576]; integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:29453251}.
sequence:
MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z5A7-1; Sequence=Displayed; Name=2; IsoId=Q7Z5A7-2; Sequence=VSP_016068; Note=Contains a predicted signal peptide at positions 1-25. {ECO:0000305}; Name=3; IsoId=Q7Z5A7-3; Sequence=VSP_035191; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q8TCP9
geneSymbol: FAM200A
name: Protein FAM200A
length: 573
go: ENSG00000221909;
opentargets: integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q5T7M9
geneSymbol: FAM69A
name: Protein FAM69A
length: 428
go: ENSG00000154511;
opentargets: endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T7M9-1; Sequence=Displayed; Name=2; IsoId=Q5T7M9-2; Sequence=VSP_024140, VSP_024141; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.


uniprotID: Q08E93
geneSymbol: FAM27E3
name: Protein FAM27E3
length: 113
sequence:
MGIFQLLRDRRISSRGPGLHTPKAEPRRRKGLTTGLMTQAERQKQAHQRQAAMRETALWCTGHIRPRTHTHTGTHTQTDRERERNTQRLRDRERRENGRHTHTYTHRHTHRVL


uniprotID: Q9UKT5
geneSymbol: FBXO4
reactome: R-HSA-390471;R-HSA-8951664;R-HSA-983168;
pdb: 3L2O;3L82;
name: F-box only protein 4
length: 387
go: ENSG00000151876;
snps: rs2231917
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; protein homodimerization activity [GO:0042803]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; aging [GO:0007568]; cellular homeostasis [GO:0019725]; cellular response to ionizing radiation [GO:0071479]; common myeloid progenitor cell proliferation [GO:0035726]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of protein localization to nucleus [GO:1900181]; positive regulation of protein polyubiquitination [GO:1902916]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of telomere maintenance via telomerase [GO:0032212]; post-translational protein modification [GO:0043687]; posttranscriptional regulation of gene expression [GO:0010608]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of DNA damage checkpoint [GO:2000001]; regulation of protein stability [GO:0031647]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; telomere maintenance [GO:0000723]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UKT5-1; Sequence=Displayed; Name=2; IsoId=Q9UKT5-2; Sequence=VSP_012977, VSP_012978; Note=No experimental confirmation available.; 


uniprotID: Q6X9E4
geneSymbol: FBXW12
reactome: R-HSA-8951664;R-HSA-983168;
length: 464
go: ENSG00000164049;
snps: rs17080138 rs6442117 rs6784322
name:
F-box/WD repeat-containing protein 12 (F-box and WD-40 domain-containing protein 12) (F-box only protein 35)

sequence:

opentargets:
cytosol [GO:0005829]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6X9E4-1; Sequence=Displayed; Name=2; IsoId=Q6X9E4-2; Sequence=VSP_042911; Note=No experimental confirmation available.; Name=3; IsoId=Q6X9E4-3; Sequence=VSP_044601; Note=No experimental confirmation available.; 


uniprotID: P30273
geneSymbol: FCER1G
sequence: MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ
length: 86
go: ENSG00000158869;
drug: DB00895;
reactome:
R-HSA-114604;R-HSA-202733;R-HSA-2454202;R-HSA-2730905;R-HSA-2871796;R-HSA-2871809;R-HSA-2871837;R-HSA-5621480;R-HSA-6798695;R-HSA-75892;

name:
High affinity immunoglobulin epsilon receptor subunit gamma (Fc receptor gamma-chain) (FcRgamma) (Fc-epsilon RI-gamma) (IgE Fc receptor subunit gamma) (FceRI gamma)

opentargets:
cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; Fc-epsilon receptor I complex [GO:0032998]; ficolin-1-rich granule membrane [GO:0101003]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; tertiary granule membrane [GO:0070821]; IgE binding [GO:0019863]; IgE receptor activity [GO:0019767]; IgG binding [GO:0019864]; protein homodimerization activity [GO:0042803]; antigen processing and presentation of exogenous peptide antigen via MHC class I [GO:0042590]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; blood coagulation [GO:0007596]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; defense response to bacterium [GO:0042742]; Fc receptor mediated stimulatory signaling pathway [GO:0002431]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway [GO:0038094]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; integrin-mediated signaling pathway [GO:0007229]; interleukin-2 production [GO:0032623]; interleukin-3-mediated signaling pathway [GO:0038156]; leukocyte migration [GO:0050900]; mast cell activation [GO:0045576]; negative regulation of mast cell apoptotic process [GO:0033026]; neutrophil activation involved in immune response [GO:0002283]; neutrophil chemotaxis [GO:0030593]; neutrophil degranulation [GO:0043312]; osteoclast differentiation [GO:0030316]; phagocytosis, engulfment [GO:0006911]; platelet activation [GO:0030168]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-4 production [GO:0032753]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of mast cell cytokine production [GO:0032765]; positive regulation of mast cell degranulation [GO:0043306]; positive regulation of phagocytosis [GO:0050766]; positive regulation of protein localization to cell surface [GO:2000010]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type I hypersensitivity [GO:0001812]; positive regulation of type IIa hypersensitivity [GO:0001798]; positive regulation of type III hypersensitivity [GO:0001805]; protein homooligomerization [GO:0051260]; protein localization to plasma membrane [GO:0072659]; receptor internalization [GO:0031623]; regulation of platelet activation [GO:0010543]; serotonin secretion by platelet [GO:0002554]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; T cell differentiation involved in immune response [GO:0002292]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:8611682}.


uniprotID: Q96LA5
geneSymbol: FCRL2
length: 508
go: ENSG00000132704;
snps: rs16839100
name:
Fc receptor-like protein 2 (FcR-like protein 2) (FcRL2) (Fc receptor homolog 2) (FcRH2) (IFGP family protein 4) (Immunoglobulin receptor translocation-associated protein 4) (SH2 domain-containing phosphatase anchor protein 1) (CD antigen CD307b)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; SH3/SH2 adaptor activity [GO:0005070]; cell-cell signaling [GO:0007267]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96LA5-1; Sequence=Displayed; Name=2; Synonyms=SPAP1A; IsoId=Q96LA5-2; Sequence=VSP_014111, VSP_014112; Name=3; Synonyms=SPAP1B; IsoId=Q96LA5-3; Sequence=VSP_014111, VSP_014112, VSP_014116, VSP_014117; Name=4; Synonyms=SPAP1C; IsoId=Q96LA5-4; Sequence=VSP_014111, VSP_014112, VSP_014114, VSP_014115; Name=5; IsoId=Q96LA5-5; Sequence=VSP_014113, VSP_014118; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.


uniprotID: P23142
geneSymbol: FBLN1
reactome: R-HSA-2129379;
name: Fibulin-1 (FIBL-1)
length: 703
go: ENSG00000077942;
snps: rs136730 rs397509432 rs1802787 rs13268
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; elastic fiber [GO:0071953]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; extracellular matrix structural constituent [GO:0005201]; fibrinogen binding [GO:0070051]; fibronectin binding [GO:0001968]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; peptidase activator activity [GO:0016504]; protein C-terminus binding [GO:0008022]; protein-containing complex binding [GO:0044877]; blood coagulation, fibrin clot formation [GO:0072378]; embryo implantation [GO:0007566]; extracellular matrix organization [GO:0030198]; negative regulation of cell adhesion [GO:0007162]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of stem cell proliferation [GO:2000647]; negative regulation of substrate adhesion-dependent cell spreading [GO:1900025]; negative regulation of transformation of host cell by virus [GO:1904188]; negative regulation of transforming growth factor-beta secretion [GO:2001202]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of gene expression [GO:0010628]; positive regulation of substrate-dependent cell migration, cell attachment to substrate [GO:1904237]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=D; IsoId=P23142-1; Sequence=Displayed; Name=A; IsoId=P23142-2; Sequence=VSP_001383; Name=B; IsoId=P23142-3; Sequence=VSP_001384; Name=C; IsoId=P23142-4; Sequence=VSP_001385; 


uniprotID: Q8NEA4
geneSymbol: FBXO36
name: F-box only protein 36
length: 188
go: ENSG00000153832;
snps: rs1035834
sequence:
MASWLPETLFETVGQGPPPSKDYYQLLVTRSQVIFRWWKISLRSEYRSTKPGEAKETHEDFLENSHLQGQTALIFGARILDYVINLCKGKFDFLERLSDDLLLTIISYLDLEDIARLCQTSHRFAKLCMSDKLWEQIVQSTCDTITPDVRALAEDTGWRQLFFTNKLQLQRQLRKRKQKYGNLREKQP

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NEA4-1; Sequence=Displayed; Name=2; IsoId=Q8NEA4-3; Sequence=VSP_054336; Note=No experimental confirmation available.; 


uniprotID: Q6BAA4
geneSymbol: FCRLB
length: 426
go: ENSG00000162746;
name:
Fc receptor-like B (Fc receptor homolog expressed in B-cells protein 2) (FREB-2) (Fc receptor-like and mucin-like protein 2) (Fc receptor-like protein 2) (Fc receptor-related protein Y) (FcRY)

sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; negative regulation of immune response [GO:0050777]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q6BAA4-1; Sequence=Displayed; Name=2; Synonyms=FCRL2c1; IsoId=Q6BAA4-2; Sequence=VSP_033421, VSP_033422; Name=3; Synonyms=FCRL2c2; IsoId=Q6BAA4-3; Sequence=VSP_033419, VSP_033421, VSP_033422; Name=4; Synonyms=FCRL2b1; IsoId=Q6BAA4-4; Sequence=VSP_033420, VSP_033423; Name=5; Synonyms=FCRL2b2; IsoId=Q6BAA4-5; Sequence=VSP_033419, VSP_033420, VSP_033423; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15551350, ECO:0000269|PubMed:15676285, ECO:0000269|PubMed:15815692}. Endoplasmic reticulum {ECO:0000305|PubMed:15815692}. Note=Seems not to be secreted. {ECO:0000269|PubMed:15676285}.


uniprotID: Q15485
geneSymbol: FCN2
reactome: R-HSA-166662;R-HSA-166663;R-HSA-2855086;
pdb: 2J0G;2J0H;2J0Y;2J1G;2J2P;2J3F;2J3G;2J3O;2J3U;2J61;4NYT;4R9J;4R9T;
length: 313
go: ENSG00000160339;
snps: rs17549179 rs12684476 rs17549193 rs7851696
location: SUBCELLULAR LOCATION: Secreted.
name:
Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35)

sequence:

opentargets:
blood microparticle [GO:0072562]; collagen trimer [GO:0005581]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; antigen binding [GO:0003823]; calcium-dependent protein binding [GO:0048306]; mannan binding [GO:2001065]; metal ion binding [GO:0046872]; proteoglycan binding [GO:0043394]; serine-type endopeptidase activity [GO:0004252]; complement activation [GO:0006956]; complement activation, lectin pathway [GO:0001867]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; opsonization [GO:0008228]; recognition of apoptotic cell [GO:0043654]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15485-1; Sequence=Displayed; Name=2; IsoId=Q15485-2; Sequence=VSP_030027; Note=No experimental confirmation available.; 


uniprotID: Q8TF61
geneSymbol: FBXO41
reactome: R-HSA-8951664;R-HSA-983168;
name: F-box only protein 41
length: 875
go: ENSG00000163013;
sequence:

opentargets:
cytosol [GO:0005829]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; protein polyubiquitination [GO:0000209]


uniprotID: Q9UKT7
geneSymbol: FBXL3
reactome: R-HSA-390471;R-HSA-400253;R-HSA-8951664;R-HSA-983168;
pdb: 4I6J;
name: F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)
length: 428
go: ENSG00000005812;
sequence:

opentargets:
cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleus [GO:0005634]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin ligase complex [GO:0000151]; ubiquitin-protein transferase activity [GO:0004842]; entrainment of circadian clock by photoperiod [GO:0043153]; post-translational protein modification [GO:0043687]; protein destabilization [GO:0031648]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; regulation of circadian rhythm [GO:0042752]; rhythmic process [GO:0048511]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10531035}. Cytoplasm {ECO:0000269|PubMed:10531035}. Note=Predominantly nuclear.


uniprotID: Q8IX29
geneSymbol: FBXO16
name: F-box only protein 16
length: 292
go: ENSG00000214050;
snps: rs3735726 rs1390963 rs7016831
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IX29-1; Sequence=Displayed; Name=2; IsoId=Q8IX29-2; Sequence=VSP_045600; Note=No experimental confirmation available.; 


uniprotID: P55899
geneSymbol: FCGRT
pdb: 1EXU;3M17;3M1B;4K71;4N0F;4N0U;5BJT;5BXF;5WHK;6C97;6C98;6C99;6FGB;
length: 365
go: ENSG00000104870;
name:
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; beta-2-microglobulin binding [GO:0030881]; IgG binding [GO:0019864]; IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor [GO:0002416]; immune response [GO:0006955]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13599}; Single-pass type I membrane protein {ECO:0000255}.


uniprotID: Q96M78
geneSymbol: FER1L6-AS2
length: 137
snps: rs13258808
name:
Putative uncharacterized protein encoded by FER1L6-AS2 (FER1L6 antisense RNA 2) (FER1L6 antisense gene protein 2)

sequence:
MSQVGRVRSSHHFESVCLDAEVRVVLVALDHAGLHTLSSALNESLRPIHREELHLLHFPNSPEENLRKRPAEPSPQIHGGAPHLPWLCVEKLDLLPENHAVFLQERTAQLFEGSFFFSRSPAHSISPLLQFRWGHCP


uniprotID: Q9UHY8
geneSymbol: FEZ2
name: Fasciculation and elongation protein zeta-2 (Zygin II) (Zygin-2)
length: 353
go: ENSG00000171055;
snps: rs1544655 rs848642
sequence:

opentargets:
axon [GO:0030424]; cytoplasm [GO:0005737]; axon guidance [GO:0007411]; negative regulation of autophagosome assembly [GO:1902902]; nervous system development [GO:0007399]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UHY8-1; Sequence=Displayed; Name=2; IsoId=Q9UHY8-2; Sequence=VSP_041368; 


uniprotID: Q13642
geneSymbol: FHL1
pdb: 1X63;2CUP;2CUR;2EGQ;
name: Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM-protein 1) (SLIM) (SLIM-1)
length: 323
go: ENSG00000022267;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ion channel binding [GO:0044325]; metal ion binding [GO:0046872]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; muscle organ development [GO:0007517]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; positive regulation of potassium ion transport [GO:0043268]; regulation of membrane depolarization [GO:0003254]; regulation of potassium ion transmembrane transporter activity [GO:1901016]

snps:
rs122459147 rs122458140 rs267606812 rs267606813 rs122458142 rs122458143 rs122459146 rs122458144 rs122458145 rs122459149 rs122458141 rs267606811 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=2; Synonyms=FHL1B, SLIMMER; IsoId=Q13642-2; Sequence=Displayed; Name=1; Synonyms=FHL1, FHL1A, SLIM1; IsoId=Q13642-1; Sequence=VSP_010694; Name=3; Synonyms=FHL1C; IsoId=Q13642-3; Sequence=VSP_010693; Name=4; IsoId=Q13642-4; Sequence=VSP_043162, VSP_010694; Note=No experimental confirmation available.; Name=5; IsoId=Q13642-5; Sequence=VSP_043404, VSP_010694; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes.


uniprotID: Q99581
geneSymbol: FEV
pdb: 2YPR;3ZP5;
length: 238
go: ENSG00000163497;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:12761502}.
name:
Protein FEV (Fifth Ewing variant protein) (PC12 ETS domain-containing transcription factor 1) (PC12 ETS factor 1) (Pet-1)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714]; cell differentiation [GO:0030154]; neuron fate specification [GO:0048665]; neuron maturation [GO:0042551]; positive regulation of gene expression [GO:0010628]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription by RNA polymerase II [GO:0006366]


uniprotID: A8MWK0
geneSymbol: FADS2P1
name: Putative fatty acid desaturase 2-like protein FADS2P1 (Fatty acid desaturase 2 pseudogene 1)
length: 482
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; unsaturated fatty acid biosynthetic process [GO:0006636]


uniprotID: O95302
geneSymbol: FKBP9
reactome: R-HSA-390471;
length: 570
go: ENSG00000122642;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
name:
Peptidyl-prolyl cis-trans isomerase FKBP9 (PPIase FKBP9) (EC 5.2.1.8) (63 kDa FK506-binding protein) (63 kDa FKBP) (FKBP-63) (FK506-binding protein 9) (FKBP-9) (Rotamase)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; calcium ion binding [GO:0005509]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; protein folding [GO:0006457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O95302-1; Sequence=Displayed; Name=2; IsoId=O95302-2; Sequence=VSP_054825; Name=3; IsoId=O95302-3; Sequence=VSP_054826; 


uniprotID: A4FU69
geneSymbol: EFCAB5
name: EF-hand calcium-binding domain-containing protein 5
length: 1503
go: ENSG00000176927;
opentargets: calcium ion binding [GO:0005509]
snps: rs9897794 rs4795524 rs9900546 rs9894896 rs4499292 rs35724168
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=A4FU69-1; Sequence=Displayed; Name=2; IsoId=A4FU69-2; Sequence=VSP_030734, VSP_030735; Name=3; IsoId=A4FU69-3; Sequence=VSP_030732; Name=4; IsoId=A4FU69-4; Sequence=VSP_030733; Name=5; IsoId=A4FU69-5; Sequence=VSP_047184, VSP_047185, VSP_047186; Note=No experimental confirmation available.; Name=6; IsoId=A4FU69-6; Sequence=VSP_055510, VSP_047185, VSP_047186; Note=No experimental confirmation available.; 


uniprotID: Q9NTX5
geneSymbol: ECHDC1
length: 307
go: ENSG00000093144;
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
name:
Ethylmalonyl-CoA decarboxylase (EC 4.1.1.94) (Enoyl-CoA hydratase domain-containing protein 1) (Methylmalonyl-CoA decarboxylase) (MMCD) (EC 7.2.4.3)

sequence:

opentargets:
cytosol [GO:0005829]; carboxy-lyase activity [GO:0016831]; enoyl-CoA hydratase activity [GO:0004300]; methylmalonyl-CoA decarboxylase activity [GO:0004492]; fatty acid beta-oxidation [GO:0006635]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q9NTX5-1; Sequence=Displayed; Name=2; IsoId=Q9NTX5-2; Sequence=VSP_022498; Name=3; IsoId=Q9NTX5-3; Sequence=VSP_042581; Note=No experimental confirmation available.; Name=4; Synonyms=HEL-S-76; IsoId=Q9NTX5-4; Sequence=VSP_042581, VSP_042583; Name=5; IsoId=Q9NTX5-5; Sequence=VSP_022498, VSP_042583; Note=No experimental confirmation available. {ECO:0000244|PubMed:22814378}; Name=6; IsoId=Q9NTX5-6; Sequence=VSP_022498, VSP_042582; Note=No experimental confirmation available. {ECO:0000244|PubMed:22814378}; 


uniprotID: A0A1B0GTR0
geneSymbol: EDDM13
name: Epididymal protein 13
length: 161
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MHRSEPFLKMSLLILLFLGLAEACTPREVATKEKINLLKGIIGLMSRLSPDGLRHNITSLKMPPLVSPQDRTEEEIKKILGLLSLQVLHEETSGCKEEVKPFSGTTPSRKPLPKRKNTWNFLKCAYMVMTYLFVSYNKGDWCYCHYCNLELDIRDDPCCSF


uniprotID: P19419
geneSymbol: ELK1
reactome: R-HSA-198753;
pdb: 1DUX;5VVT;
name: ETS domain-containing protein Elk-1
length: 428
go: ENSG00000126767;
snps: rs1997639 rs1059579
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
axon terminus [GO:0043679]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; cell differentiation [GO:0030154]; cellular response to gamma radiation [GO:0071480]; cellular response to testosterone stimulus [GO:0071394]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; response to fibroblast growth factor [GO:0071774]; response to light stimulus [GO:0009416]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P19419-1; Sequence=Displayed; Name=2; Synonyms=ELKV; IsoId=P19419-2; Sequence=VSP_001466, VSP_001467; 


uniprotID: P41970
geneSymbol: ELK3
length: 407
go: ENSG00000111145;
snps: rs35332676
location: SUBCELLULAR LOCATION: Nucleus.
name:
ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)

sequence:

opentargets:
mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; purine-rich negative regulatory element binding [GO:0032422]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription corepressor activity [GO:0003714]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; wound healing [GO:0042060]


uniprotID: P0DMC3
geneSymbol: APELA
name: Apelin receptor early endogenous ligand (Protein Elabela) (ELA) (Protein Toddler)
sequence: MRFQQFLFAFFIFIMSLLLISGQRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP
length: 54
go: ENSG00000248329;
opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; apelin receptor binding [GO:0031704]; hormone activity [GO:0005179]; adult heart development [GO:0007512]; angiogenesis [GO:0001525]; apelin receptor signaling pathway [GO:0060183]; cell migration involved in mesendoderm migration [GO:0090134]; coronary vasculature development [GO:0060976]; embryonic heart tube development [GO:0035050]; endoderm development [GO:0007492]; heart development [GO:0007507]; mesendoderm migration [GO:0090133]; mesoderm migration involved in gastrulation [GO:0007509]; placenta blood vessel development [GO:0060674]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor internalization [GO:1904022]; positive regulation of heart contraction [GO:0045823]; positive regulation of trophoblast cell migration [GO:1901165]; vasculogenesis [GO:0001570]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24316148, ECO:0000269|PubMed:28137936}. Secreted, extracellular space {ECO:0000269|PubMed:28137936}. Note=Found in blood plasma (PubMed:28137936). Found in serum of pregnant mice, peaking at midgestation; indicating a maternal and zygotic origin of circulating APELA during pregnancy (By similarity). {ECO:0000250|UniProtKB:P0DMC4}.


uniprotID: Q9BW60
geneSymbol: ELOVL1
reactome: R-HSA-2046105;R-HSA-2046106;R-HSA-75876;
length: 279
go: ENSG00000066322;
name:
Elongation of very long chain fatty acids protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; membrane [GO:0016020]; 3-oxo-arachidoyl-CoA synthase activity [GO:0102336]; 3-oxo-cerotoyl-CoA synthase activity [GO:0102337]; 3-oxo-lignoceronyl-CoA synthase activity [GO:0102338]; fatty acid elongase activity [GO:0009922]; very-long-chain 3-ketoacyl-CoA synthase activity [GO:0102756]; alpha-linolenic acid metabolic process [GO:0036109]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; linoleic acid metabolic process [GO:0043651]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BW60-1; Sequence=Displayed; Name=2; IsoId=Q9BW60-2; Sequence=VSP_045436; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03201, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03201}.


uniprotID: P55199
geneSymbol: ELL
pdb: 2DOA;
name: RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein)
length: 621
go: ENSG00000105656;
snps: rs2303694 rs35245196
reactome:
R-HSA-112382;R-HSA-167152;R-HSA-167200;R-HSA-167238;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-674695;R-HSA-6781827;R-HSA-6796648;R-HSA-6807505;R-HSA-75955;

sequence:

opentargets:
Cajal body [GO:0015030]; histone locus body [GO:0035363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; transcription elongation factor complex [GO:0008023]; transcriptionally active chromatin [GO:0035327]; phosphatase binding [GO:0019902]; in utero embryonic development [GO:0001701]; negative regulation of phosphatase activity [GO:0010923]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase III [GO:0045945]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; snRNA transcription by RNA polymerase II [GO:0042795]; snRNA transcription by RNA polymerase III [GO:0042796]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus speckle {ECO:0000269|PubMed:11418481, ECO:0000269|PubMed:12446457}. Nucleus, Cajal body {ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:22195968, ECO:0000269|PubMed:23932780}. Note=Colocalizes with EAF2 to nuclear speckles (PubMed:12446457). Colocalizes with coilin in subnuclear cajal and histone locus bodies (PubMed:12686606). Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes(PubMed:23932780). {ECO:0000269|PubMed:12446457, ECO:0000269|PubMed:12686606, ECO:0000269|PubMed:23932780}.


uniprotID: Q9GZR5
geneSymbol: ELOVL4
reactome: R-HSA-75876;
length: 314
go: ENSG00000118402;
drug: DB00132;
snps: rs587777598 rs148594713 rs3812153
name:
Elongation of very long chain fatty acids protein 4 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL4) (ELOVL fatty acid elongase 4) (ELOVL FA elongase 4) (Very long chain 3-ketoacyl-CoA synthase 4) (Very long chain 3-oxoacyl-CoA synthase 4)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of endoplasmic reticulum membrane [GO:0030176]; 3-oxo-arachidoyl-CoA synthase activity [GO:0102336]; 3-oxo-cerotoyl-CoA synthase activity [GO:0102337]; 3-oxo-lignoceronyl-CoA synthase activity [GO:0102338]; fatty acid elongase activity [GO:0009922]; G protein-coupled photoreceptor activity [GO:0008020]; very-long-chain 3-ketoacyl-CoA synthase activity [GO:0102756]; fatty acid biosynthetic process [GO:0006633]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03204, ECO:0000269|PubMed:16036915, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03204}.


uniprotID: Q8WYP5
geneSymbol: AHCTF1
reactome: R-HSA-141444;R-HSA-2467813;R-HSA-2500257;R-HSA-5663220;R-HSA-68877;
length: 2266
go: ENSG00000153207;
snps: rs2642990 rs12410563
name:
Protein ELYS (Embryonic large molecule derived from yolk sac) (Protein MEL-28) (Putative AT-hook-containing transcription factor 1)

sequence:

opentargets:
condensed chromosome kinetochore [GO:0000777]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nuclear matrix [GO:0016363]; nuclear membrane [GO:0031965]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; cell cycle [GO:0007049]; cell division [GO:0051301]; mRNA transport [GO:0051028]; nuclear pore complex assembly [GO:0051292]; protein transport [GO:0015031]; regulation of cytokinesis [GO:0032465]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8WYP5-1; Sequence=Displayed; Name=2; IsoId=Q8WYP5-2; Sequence=VSP_019844; Name=3; IsoId=Q8WYP5-3; Sequence=VSP_042691; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CJF7}. Nucleus {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:27341616}. Nucleus envelope {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:27341616}. Nucleus matrix {ECO:0000269|PubMed:17098863}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17098863, ECO:0000269|PubMed:27341616}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17098863}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:17098863}. Note=Localizes to the nuclear pore complex (NPC) throughout interphase. Localizes to the kinetochore from prophase, and this appears to require the Nup107-160 subcomplex of the NPC. Localizes to the periphery of chromatin from late anaphase. {ECO:0000269|PubMed:17098863}.


uniprotID: O00423
geneSymbol: EML1
pdb: 4CI8;
name: Echinoderm microtubule-associated protein-like 1 (EMAP-1) (HuEMAP-1)
length: 815
go: ENSG00000066629;
snps: rs886037937 rs886037936 rs34198557 rs17853154 rs2250718
sequence:

opentargets:
cytosol [GO:0005829]; microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; microtubule cytoskeleton [GO:0015630]; mitotic spindle midzone [GO:1990023]; mitotic spindle pole [GO:0097431]; perinuclear region of cytoplasm [GO:0048471]; calcium ion binding [GO:0005509]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]; brain development [GO:0007420]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; neuroblast proliferation [GO:0007405]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00423-1; Sequence=Displayed; Name=3; IsoId=O00423-3; Sequence=VSP_024476; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q05BC3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q05BC3}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24859200}. Note=Detected in cytoplasmic punctae. Co-localizes with microtubules (PubMed:24859200). Enriched in perinuclear regions during interphase and in the region of spindle microtubules during metaphase. Enriched at the midzone during telophase and cytokinesis. Detected at growth cones in neurons (By similarity). {ECO:0000250|UniProtKB:Q05BC3, ECO:0000269|PubMed:24859200}.


uniprotID: Q9P0I2
geneSymbol: EMC3
name: ER membrane protein complex subunit 3 (Transmembrane protein 111)
length: 261
go: ENSG00000125037;
sequence:

opentargets:
ER membrane protein complex [GO:0072546]; integral component of membrane [GO:0016021]; protein folding in endoplasmic reticulum [GO:0034975]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P0I2-1; Sequence=Displayed; Name=2; IsoId=Q9P0I2-2; Sequence=VSP_014886; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:22119785}.


uniprotID: Q0PNE2
geneSymbol: ELP6
reactome: R-HSA-3214847;
name: Elongator complex protein 6 (Angiotonin-transactivated protein 1) (Protein TMEM103)
length: 266
go: ENSG00000163832;
sequence:

opentargets:
cytosol [GO:0005829]; Elongator holoenzyme complex [GO:0033588]; nucleus [GO:0005634]; positive regulation of cell migration [GO:0030335]; tRNA wobble uridine modification [GO:0002098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q0PNE2-1; Sequence=Displayed; Name=2; IsoId=Q0PNE2-2; Sequence=VSP_022721, VSP_022722; Note=No experimental confirmation available.; 


uniprotID: Q5J8M3
geneSymbol: EMC4
length: 183
go: ENSG00000128463;
snps: rs11544437
name:
ER membrane protein complex subunit 4 (Cell proliferation-inducing gene 17 protein) (Transmembrane protein 85)

sequence:
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL

opentargets:
ER membrane protein complex [GO:0072546]; integral component of membrane [GO:0016021]; apoptotic process [GO:0006915]; protein folding in endoplasmic reticulum [GO:0034975]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=TMEM85v1; IsoId=Q5J8M3-1; Sequence=Displayed; Name=2; Synonyms=TMEM85v2; IsoId=Q5J8M3-2; Sequence=VSP_020798, VSP_020799; Name=3; IsoId=Q5J8M3-3; Sequence=VSP_037374, VSP_037375; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000269|PubMed:22119785}.


uniprotID: Q9H5J4
geneSymbol: ELOVL6
reactome: R-HSA-2426168;R-HSA-75876;
length: 265
go: ENSG00000170522;
name:
Elongation of very long chain fatty acids protein 6 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL6) (ELOVL fatty acid elongase 6) (ELOVL FA elongase 6) (Fatty acid elongase 2) (hELO2) (Fatty acyl-CoA elongase) (Long-chain fatty-acyl elongase) (Very long chain 3-ketoacyl-CoA synthase 6) (Very long chain 3-oxoacyl-CoA synthase 6)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; 3-oxo-arachidoyl-CoA synthase activity [GO:0102336]; 3-oxo-cerotoyl-CoA synthase activity [GO:0102337]; 3-oxo-lignoceronyl-CoA synthase activity [GO:0102338]; fatty acid elongase activity [GO:0009922]; very-long-chain 3-ketoacyl-CoA synthase activity [GO:0102756]; fatty acid elongation, monounsaturated fatty acid [GO:0034625]; fatty acid elongation, polyunsaturated fatty acid [GO:0034626]; fatty acid elongation, saturated fatty acid [GO:0019367]; long-chain fatty acid biosynthetic process [GO:0042759]; long-chain fatty-acyl-CoA biosynthetic process [GO:0035338]; positive regulation of cold-induced thermogenesis [GO:0120162]; regulation of cholesterol biosynthetic process [GO:0045540]; sphingolipid biosynthetic process [GO:0030148]; unsaturated fatty acid biosynthetic process [GO:0006636]; very long-chain fatty acid biosynthetic process [GO:0042761]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03206, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03206}.


uniprotID: Q9Y3B6
geneSymbol: EMC9
name: ER membrane protein complex subunit 9 (Protein FAM158A)
length: 208
go: ENSG00000100908;
opentargets: cytoplasm [GO:0005737]; ER membrane protein complex [GO:0072546]
snps: rs11574512
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22119785}.
sequence:


uniprotID: O95163
geneSymbol: ELP1
reactome: R-HSA-3214847;
pdb: 5CQR;
length: 1332
go: ENSG00000070061;
name:
Elongator complex protein 1 (ELP1) (IkappaB kinase complex-associated protein) (IKK complex-associated protein) (p150)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Elongator holoenzyme complex [GO:0033588]; nucleolus [GO:0005730]; transcription elongation factor complex [GO:0008023]; phosphorylase kinase regulator activity [GO:0008607]; immune response [GO:0006955]; positive regulation of cell migration [GO:0030335]; protein phosphorylation [GO:0006468]; protein-containing complex assembly [GO:0065003]; regulation of transcription by RNA polymerase II [GO:0006357]; transcription elongation from RNA polymerase II promoter [GO:0006368]; tRNA wobble uridine modification [GO:0002098]

snps:
rs3737311 rs10521092 rs1140064 rs838827 rs137853022 rs2230792 rs2230793 rs2230794 rs10979599 rs2230798 rs2230795 rs3204145 rs1538660 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576, ECO:0000269|PubMed:22854966}. Nucleus {ECO:0000269|PubMed:11714725, ECO:0000269|PubMed:11818576}.


uniprotID: Q9Y6C2
geneSymbol: EMILIN1
reactome: R-HSA-2129379;
pdb: 2KA3;2OII;
name: EMILIN-1 (Elastin microfibril interface-located protein 1) (Elastin microfibril interfacer 1)
length: 1016
go: ENSG00000138080;
snps: rs753862645 rs2736976 rs36069611 rs36045790
sequence:

opentargets:
collagen trimer [GO:0005581]; collagen-containing extracellular matrix [GO:0062023]; EMILIN complex [GO:1990971]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integrin alpha4-beta1 complex [GO:0034668]; extracellular matrix constituent conferring elasticity [GO:0030023]; identical protein binding [GO:0042802]; integrin binding involved in cell-matrix adhesion [GO:0098640]; aortic valve morphogenesis [GO:0003180]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell-matrix adhesion [GO:0007160]; elastic fiber assembly [GO:0048251]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell activation [GO:0050866]; negative regulation of collagen biosynthetic process [GO:0032966]; negative regulation of collagen fibril organization [GO:1904027]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of gene expression [GO:0010629]; negative regulation of macrophage migration [GO:1905522]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of extracellular matrix assembly [GO:1901203]; positive regulation of gene expression [GO:0010628]; protein homotrimerization [GO:0070207]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y6C2-1; Sequence=Displayed; Name=2; IsoId=Q9Y6C2-2; Sequence=VSP_055478, VSP_055479, VSP_055480; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:26462740}. Note=Found mainly at the interface between amorphous elastin and microfibrils. {ECO:0000303|PubMed:10625608}.


uniprotID: Q9NT22
geneSymbol: EMILIN3
reactome: R-HSA-2129379;
length: 766
go: ENSG00000183798;
snps: rs2235592
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
name:
EMILIN-3 (EMILIN-5) (Elastin microfibril interface-located protein 3) (Elastin microfibril interfacer 3) (Elastin microfibril interface-located protein 5) (Elastin microfibril interfacer 5)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular matrix structural constituent [GO:0005201]; positive regulation of cell-substrate adhesion [GO:0010811]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NT22-1; Sequence=Displayed; Name=2; IsoId=Q9NT22-2; Sequence=VSP_055481; Note=No experimental confirmation available.; 


uniprotID: Q8NFI3
geneSymbol: ENGASE
reactome: R-HSA-532668;
name: Cytosolic endo-beta-N-acetylglucosaminidase (ENGase) (EC 3.2.1.96)
length: 743
go: ENSG00000167280;
snps: rs4789879 rs11871357
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity [GO:0033925]; protein deglycosylation [GO:0006517]; protein folding [GO:0006457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NFI3-1; Sequence=Displayed; Name=2; IsoId=Q8NFI3-2; Sequence=VSP_032836, VSP_032837; Note=No experimental confirmation available.; Name=3; IsoId=Q8NFI3-3; Sequence=VSP_032835, VSP_032838; Note=No experimental confirmation available.; 


uniprotID: Q6QHK4
geneSymbol: FIGLA
length: 219
go: ENSG00000183733;
snps: rs71647803 rs7566476
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Factor in the germline alpha (FIGalpha) (Class C basic helix-loop-helix protein 8) (bHLHc8) (Folliculogenesis-specific basic helix-loop-helix protein) (Transcription factor FIGa)

sequence:

opentargets:
nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription factor binding [GO:0008134]; multicellular organism development [GO:0007275]; oocyte development [GO:0048599]


uniprotID: Q5HY92
geneSymbol: FIGN
name: Fidgetin
length: 759
go: ENSG00000182263;
snps: rs2231902 rs2231904 rs2231905
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; microtubule-severing ATPase activity [GO:0008568]; protein C-terminus binding [GO:0008022]; cell cycle [GO:0007049]; cell division [GO:0051301]; cytoplasmic microtubule organization [GO:0031122]; regulation of double-strand break repair via homologous recombination [GO:0010569]

location:
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22672901}. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase.


uniprotID: Q4L180
geneSymbol: FILIP1L
length: 1135
go: ENSG00000168386;
opentargets: cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]
snps: rs793440 rs28362487
name:
Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90 kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=a, d; IsoId=Q4L180-1; Sequence=Displayed; Name=2; Synonyms=b, c; IsoId=Q4L180-2; Sequence=VSP_029206; Name=3; IsoId=Q4L180-3; Sequence=VSP_029201, VSP_029206; Name=4; IsoId=Q4L180-4; Sequence=VSP_029202, VSP_029203; Name=5; IsoId=Q4L180-5; Sequence=VSP_029201, VSP_029204, VSP_029205, VSP_029206; Name=6; IsoId=Q4L180-6; Sequence=VSP_036502; Name=7; IsoId=Q4L180-7; Sequence=VSP_029201; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18794120}. Membrane {ECO:0000269|PubMed:18794120}. Nucleus {ECO:0000269|PubMed:18794120}.


uniprotID: P20930
geneSymbol: FLG
reactome: R-HSA-6809371;
pdb: 4PCW;
name: Filaggrin
length: 4061
go: ENSG00000143631;
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cornified envelope [GO:0001533]; cytosol [GO:0005829]; intermediate filament [GO:0005882]; intracellular membrane-bounded organelle [GO:0043231]; keratohyalin granule [GO:0036457]; nucleus [GO:0005634]; calcium ion binding [GO:0005509]; structural constituent of epidermis [GO:0030280]; structural molecule activity [GO:0005198]; transition metal ion binding [GO:0046914]; cornification [GO:0070268]; establishment of skin barrier [GO:0061436]; keratinocyte differentiation [GO:0030216]; multicellular organism development [GO:0007275]; peptide cross-linking [GO:0018149]

snps:
rs41267154 rs11588170 rs2011331 rs11584340 rs3120655 rs3120654 rs3120649 rs11581433 rs12750571 rs11204978 rs12407807 rs12405278 rs3120647 rs12405241 rs12073613 rs12407748 rs3126079 rs142592778 rs7522925 rs7512553 rs2184953 rs3126074 rs148050570 rs3126072 rs759244716 rs2065958 rs2065957 rs3120647 rs528344105 rs7512553 rs11204978 rs2065955 rs12073613 rs113933537 rs12728908 rs571269174 rs7518080 rs3814300 rs12083389 rs9436065 rs3120647 rs537909579 rs11584340 rs7512553 rs776603551 rs768192328 rs12073613 rs146212122 rs140464988 rs3814300 rs3126065 rs3814299 

location:
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:16710414}. Note=In the stratum granulosum of the epidermis, localized within keratohyalin granules (PubMed:1429717). In granular keratinocytes and in lower corneocytes, colocalizes with calpain-1/CAPN1 (PubMed:21531719). {ECO:0000269|PubMed:1429717, ECO:0000269|PubMed:21531719}.


uniprotID: O94919
geneSymbol: ENDOD1
reactome: R-HSA-114608;
name: Endonuclease domain-containing 1 protein (EC 3.1.30.-)
length: 500
go: ENSG00000149218;
snps: rs3740862 rs3740861
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; platelet degranulation [GO:0002576]


uniprotID: Q75LS8
geneSymbol: FKBP9P1
name: Putative FK506-binding protein 9-like protein (FK506-binding protein 9-like protein pseudogene)
length: 142
opentargets: calcium ion binding [GO:0005509]
snps: rs11524166
sequence:
MDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEAKQDEL


uniprotID: Q9N2K0
length: 584
opentargets: integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
name:
HERV-H_2q24.3 provirus ancestral Env polyprotein (Env protein HERV-H/p62) (Env protein HERV-H19) (Env protein HERV-Hcl.3) (Envelope polyprotein) (HERV-H/env62) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]

sequence:

location:
SUBCELLULAR LOCATION: Virion.; SUBCELLULAR LOCATION: Transmembrane protein: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.


uniprotID: O71037
geneSymbol: ERVK-19
length: 699
name:
Endogenous retrovirus group K member 19 Env polyprotein (EnvK3 protein) (Envelope polyprotein) (HERV-K(C19) envelope protein) (HERV-K_19q11 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]

location:
SUBCELLULAR LOCATION: Transmembrane protein: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: Surface protein: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: Endogenous retrovirus group K member 19 Env polyprotein: Virion {ECO:0000250}.


uniprotID: P61565
geneSymbol: ERVK-21
length: 698
name:
Endogenous retrovirus group K member 21 Env polyprotein (EnvK1 protein) (Envelope polyprotein) (HERV-K_12q14.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein (SU); Transmembrane protein (TM)]

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; structural molecule activity [GO:0005198]

location:
SUBCELLULAR LOCATION: Transmembrane protein: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: Surface protein: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The surface protein is not anchored to the membrane, but localizes to the extracellular surface through its binding to TM. {ECO:0000250}.; SUBCELLULAR LOCATION: Endogenous retrovirus group K member 21 Env polyprotein: Virion {ECO:0000250}.


uniprotID: Q00688
geneSymbol: FKBP3
pdb: 1PBK;2KFV;2MPH;5D75;5GPG;
length: 224
go: ENSG00000100442;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Peptidyl-prolyl cis-trans isomerase FKBP3 (PPIase FKBP3) (EC 5.2.1.8) (25 kDa FK506-binding protein) (25 kDa FKBP) (FKBP-25) (FK506-binding protein 3) (FKBP-3) (Immunophilin FKBP25) (Rapamycin-selective 25 kDa immunophilin) (Rotamase)

sequence:

opentargets:
nucleus [GO:0005634]; FK506 binding [GO:0005528]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; RNA binding [GO:0003723]; signaling receptor activity [GO:0038023]


uniprotID: Q03111
geneSymbol: MLLT1
reactome: R-HSA-112382;R-HSA-674695;R-HSA-75955;
pdb: 5J9S;
name: Protein ENL (YEATS domain-containing protein 1)
length: 559
go: ENSG00000130382;
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; negative regulation of protein kinase activity [GO:0006469]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]


uniprotID: P06733
geneSymbol: ENO1
reactome: R-HSA-70171;R-HSA-70263;
pdb: 2PSN;3B97;5JLZ;5LAX;5NI9;5NIG;
length: 434
go: ENSG00000074800;
snps: rs11544513 rs11544514
name:
Alpha-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (C-myc promoter-binding protein) (Enolase 1) (MBP-1) (MPB-1) (Non-neural enolase) (NNE) (Phosphopyruvate hydratase) (Plasminogen-binding protein)

sequence:

opentargets:
cell cortex region [GO:0099738]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; M band [GO:0031430]; membrane [GO:0016020]; nucleus [GO:0005634]; phosphopyruvate hydratase complex [GO:0000015]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; phosphopyruvate hydratase activity [GO:0004634]; protein homodimerization activity [GO:0042803]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA binding [GO:0003723]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; canonical glycolysis [GO:0061621]; gluconeogenesis [GO:0006094]; negative regulation of cell growth [GO:0030308]; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway [GO:1903298]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of muscle contraction [GO:0045933]; positive regulation of plasminogen activation [GO:0010756]; response to virus [GO:0009615]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=alpha-enolase; IsoId=P06733-1; Sequence=Displayed; Name=MBP-1; IsoId=P06733-2; Sequence=VSP_018725; Note=It is uncertain whether the alternative initiation site is at Met-94 or at Met-97.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10802057}. Cell membrane {ECO:0000269|PubMed:10802057}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:10802057}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.; SUBCELLULAR LOCATION: Isoform MBP-1: Nucleus.


