# annotation

uniprotID: Q8NEY3
geneSymbol: SPATA4
length: 305
go: ENSG00000150628;
snps: rs17062589
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15158438}.
name:
Spermatogenesis-associated protein 4 (Testis and spermatogenesis cell-related protein 2) (Testis spermatocyte apoptosis-related gene 2 protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]; cilium-dependent cell motility [GO:0060285]


uniprotID: Q8IXZ3
geneSymbol: SP8
name: Transcription factor Sp8 (Specificity protein 8)
length: 490
go: ENSG00000164651;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; dorsal/ventral pattern formation [GO:0009953]; embryonic limb morphogenesis [GO:0030326]; proximal/distal pattern formation [GO:0009954]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=3; IsoId=Q8IXZ3-3; Sequence=Displayed; Name=1; IsoId=Q8IXZ3-1; Sequence=VSP_011036; Note=No experimental confirmation available.; Name=2; IsoId=Q8IXZ3-2; Sequence=VSP_007441; Note=No experimental confirmation available.; Name=4; Synonyms=Sp8L; IsoId=Q8IXZ3-4; Sequence=VSP_044094; 


uniprotID: P52657
geneSymbol: GTF2A2
pdb: 1NVP;5FUR;5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;5M4S;
length: 109
go: ENSG00000140307;
location: SUBCELLULAR LOCATION: Nucleus.
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-674695;R-HSA-6807505;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;R-HSA-9018519;

name:
Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma)

sequence:
MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

opentargets:
cell junction [GO:0030054]; nucleoplasm [GO:0005654]; transcription factor TFIIA complex [GO:0005672]; transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; RNA polymerase II repressing transcription factor binding [GO:0001103]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of transcription by RNA polymerase II [GO:0045944]; RNA polymerase II preinitiation complex assembly [GO:0051123]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]


uniprotID: O75934
geneSymbol: BCAS2
reactome: R-HSA-72163;
pdb: 5MQF;5XJC;5YZG;5Z56;5Z57;
length: 225
go: ENSG00000116752;
snps: rs1197668726
name:
Pre-mRNA-splicing factor SPF27 (Breast carcinoma-amplified sequence 2) (DNA amplified in mammary carcinoma 1 protein) (Spliceosome-associated protein SPF 27)

sequence:

opentargets:
centrosome [GO:0005813]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Prp19 complex [GO:0000974]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12169396, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:20176811}.


uniprotID: Q99865
geneSymbol: SPIN2A
name: Spindlin-2A (Protein DXF34) (Spindlin-like protein 2A) (SPIN-2) (SPIN-2A)
length: 258
go: ENSG00000147059;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BPZ2}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; cell cycle [GO:0007049]; gamete generation [GO:0007276]; regulation of cell cycle [GO:0051726]


uniprotID: Q2MJR0
geneSymbol: SPRED3
reactome: R-HSA-5658442;R-HSA-6802949;
name: Sprouty-related, EVH1 domain-containing protein 3 (Spred-3)
length: 410
go: ENSG00000188766;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
sequence:

opentargets:
membrane [GO:0016020]; multicellular organism development [GO:0007275]; regulation of signal transduction [GO:0009966]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2MJR0-1; Sequence=Displayed; Name=2; Synonyms=EVE-3; IsoId=Q2MJR0-2; Sequence=VSP_042949, VSP_042950; 


uniprotID: Q8NFR3
geneSymbol: SPTSSB
reactome: R-HSA-1660661;
sequence: MDLRRVKEYFSWLYYQYQIISCCAVLEPWERSMFNTILLTIIAMVVYTAYVFIPIHIRLAWEFFSKICGYHSTISN
length: 76
go: ENSG00000196542;
name:
Serine palmitoyltransferase small subunit B (Protein ADMP) (Small subunit of serine palmitoyltransferase B) (ssSPTb)

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; serine C-palmitoyltransferase complex [GO:0017059]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; endoplasmic reticulum organization [GO:0007029]; regulation of serine C-palmitoyltransferase activity [GO:1904220]; sphingolipid biosynthetic process [GO:0030148]


uniprotID: P31391
geneSymbol: SSTR4
reactome: R-HSA-375276;R-HSA-418594;
name: Somatostatin receptor type 4 (SS-4-R) (SS4-R) (SS4R)
length: 388
go: ENSG00000132671;
snps: rs1065191 rs35601930 rs3746726 rs2567608
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]; cell migration [GO:0016477]; cellular response to glucocorticoid stimulus [GO:0071385]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0106072]; negative regulation of cell proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of arachidonic acid secretion [GO:0090238]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]


uniprotID: P08240
geneSymbol: SRPRA
reactome: R-HSA-1799339;R-HSA-381038;
pdb: 2FH5;2GO5;5L3Q;
name: Signal recognition particle receptor subunit alpha (SR-alpha) (Docking protein alpha) (DP-alpha)
length: 638
go: ENSG00000182934;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; signal recognition particle receptor complex [GO:0005785]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; cotranslational protein targeting to membrane [GO:0006613]; IRE1-mediated unfolded protein response [GO:0036498]; protein targeting to ER [GO:0045047]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P08240-1; Sequence=Displayed; Name=2; IsoId=P08240-2; Sequence=VSP_046055; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain.


uniprotID: P40763
geneSymbol: STAT3
pdb: 5AX3;5U5S;
name: Signal transducer and activator of transcription 3 (Acute-phase response factor)
length: 770
go: ENSG00000168610;
reactome:
R-HSA-1059683;R-HSA-111453;R-HSA-1266695;R-HSA-1433557;R-HSA-1839117;R-HSA-186763;R-HSA-198745;R-HSA-2559582;R-HSA-2586552;R-HSA-2892247;R-HSA-390471;R-HSA-452723;R-HSA-6783783;R-HSA-6785807;R-HSA-8849474;R-HSA-8854691;R-HSA-8875791;R-HSA-8983432;R-HSA-8984722;R-HSA-8985947;R-HSA-9008059;R-HSA-9020933;R-HSA-9020956;R-HSA-9020958;R-HSA-982772;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; mitochondrial inner membrane [GO:0005743]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; RNA polymerase II transcription factor complex [GO:0090575]; Schaffer collateral - CA1 synapse [GO:0098685]; CCR5 chemokine receptor binding [GO:0031730]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; glucocorticoid receptor binding [GO:0035259]; identical protein binding [GO:0042802]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II repressing transcription factor binding [GO:0001103]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; acute-phase response [GO:0006953]; aging [GO:0007568]; astrocyte differentiation [GO:0048708]; cell proliferation [GO:0008283]; cellular response to cytokine stimulus [GO:0071345]; cellular response to hormone stimulus [GO:0032870]; cellular response to leptin stimulus [GO:0044320]; cellular response to organic cyclic compound [GO:0071407]; cytokine-mediated signaling pathway [GO:0019221]; eating behavior [GO:0042755]; energy homeostasis [GO:0097009]; eye photoreceptor cell differentiation [GO:0001754]; glucose homeostasis [GO:0042593]; growth hormone receptor signaling pathway [GO:0060396]; inflammatory response [GO:0006954]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-21-mediated signaling pathway [GO:0038114]; interleukin-23-mediated signaling pathway [GO:0038155]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-35-mediated signaling pathway [GO:0070757]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; intracellular receptor signaling pathway [GO:0030522]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; leptin-mediated signaling pathway [GO:0033210]; miRNA mediated inhibition of translation [GO:0035278]; modulation of chemical synaptic transmission [GO:0050804]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of glycolytic process [GO:0045820]; negative regulation of hydrogen peroxide biosynthetic process [GO:0010730]; negative regulation of neuron death [GO:1901215]; negative regulation of neuron migration [GO:2001223]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; phosphorylation [GO:0016310]; positive regulation of angiogenesis [GO:0045766]; positive regulation of ATP biosynthetic process [GO:2001171]; positive regulation of cell migration [GO:0030335]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gene expression [GO:0010628]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [GO:1902728]; positive regulation of metalloendopeptidase activity [GO:1904685]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; positive regulation of vascular endothelial cell proliferation [GO:1905564]; postsynapse to nucleus signaling pathway [GO:0099527]; protein import into nucleus [GO:0006606]; radial glial cell differentiation [GO:0060019]; regulation of cell cycle [GO:0051726]; regulation of feeding behavior [GO:0060259]; regulation of mitochondrial membrane permeability [GO:0046902]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; response to estradiol [GO:0032355]; response to ethanol [GO:0045471]; response to leptin [GO:0044321]; sexual reproduction [GO:0019953]; signal transduction [GO:0007165]; somatic stem cell population maintenance [GO:0035019]; T-helper 17 cell lineage commitment [GO:0072540]; temperature homeostasis [GO:0001659]; viral process [GO:0016032]

snps:
rs1803125 rs17878478 rs113994136 rs113994136 rs113994135 rs397514766 rs587777648 rs113994137 rs1064116 rs113994139 rs587777649 rs193922721 rs587777650 rs869312892 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P40763-1; Sequence=Displayed; Name=Del-701; IsoId=P40763-2; Sequence=VSP_010474; Name=3; IsoId=P40763-3; Sequence=VSP_055918, VSP_055919; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000269|PubMed:28065600}. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.


uniprotID: Q13043
geneSymbol: STK4
reactome: R-HSA-2028269;
pdb: 2JO8;3COM;4NR2;4OH8;5TWG;5TWH;
length: 487
go: ENSG00000101109;
snps: rs55850759 rs35447878 rs17420378 rs35944046 rs33963346
name:
Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; transcription factor binding [GO:0008134]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; branching involved in blood vessel morphogenesis [GO:0001569]; cell differentiation involved in embryonic placenta development [GO:0060706]; cell morphogenesis [GO:0000902]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; keratinocyte differentiation [GO:0030216]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular associated smooth muscle cell apoptotic process [GO:1905461]; primitive hemopoiesis [GO:0060215]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; signal transduction [GO:0007165]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13043-1; Sequence=Displayed; Name=2; IsoId=Q13043-2; Sequence=VSP_019851, VSP_019852; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The caspase-cleaved form cycles between the nucleus and cytoplasm.


uniprotID: Q6IQ16
geneSymbol: SPOPL
reactome: R-HSA-5632684;
name: Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2)
length: 392
go: ENSG00000144228;
snps: rs36099753
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
Cul3-RING ubiquitin ligase complex [GO:0031463]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of protein ubiquitination [GO:0031397]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; regulation of proteolysis [GO:0030162]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q9BXN6
geneSymbol: SPANXD
sequence: MDKQSSAGGVKRSVPCDSNEANEMMPETSSGYSDPQPAPKKLKTSESSTILVVRYRRNFKRTSPEELVNDHARKNRINPLQMEEEEFMEIMVEIPAK
length: 97
go: ENSG00000196406;
opentargets: cytoplasm [GO:0005737]; nucleus [GO:0005634]
snps: rs5953618
name:
Sperm protein associated with the nucleus on the X chromosome D (Cancer/testis antigen 11.4) (CT11.4) (Nuclear-associated protein SPAN-Xd) (SPANX-D) (SPANX family member D)

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Associated with nuclear craters. {ECO:0000250}.


uniprotID: Q8NHX4
geneSymbol: SPATA3
length: 192
go: ENSG00000173699;
name:
Spermatogenesis-associated protein 3 (Testis and spermatogenesis cell-related protein 1) (Testis spermatocyte apoptosis-related protein 1)

sequence:
MKKVKKKRSEARRHRDSTSQHASSNSTSQQPSPESTPQQPSPESTPQQPSPESTPQHSSLETTSRQPAFQALPAPEIRRSSCCLLSPDANVKAAPQSRKAGPLIRAGPHSCSCATCPCSSACWRRLGLCHSRIFDVLLPRDWQMAPGRGLPNLLTFYRKSSRKPSSHRNACPPSPRNCGCGSGGSRSCLLHH


uniprotID: Q99611
geneSymbol: SEPHS2
reactome: R-HSA-2408557;
name: Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2)
length: 448
go: ENSG00000179918;
snps: rs1804600
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; selenide, water dikinase activity [GO:0004756]; selenium compound metabolic process [GO:0001887]; selenocysteine biosynthetic process [GO:0016260]; selenocysteine metabolic process [GO:0016259]; tRNA seleno-modification [GO:0070329]


uniprotID: O15269
geneSymbol: SPTLC1
reactome: R-HSA-1660661;
length: 473
go: ENSG00000090054;
drug: DB00133;DB00114;
name:
Serine palmitoyltransferase 1 (EC 2.3.1.50) (Long chain base biosynthesis protein 1) (LCB 1) (Serine-palmitoyl-CoA transferase 1) (SPT 1) (SPT1)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; serine C-palmitoyltransferase complex [GO:0017059]; SPOTS complex [GO:0035339]; pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingolipid metabolic process [GO:0006665]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]

snps:
rs119482082 rs119482081 rs119482083 rs45461899 rs542876370 rs768841574 rs267607087 rs267607087 rs267607088 rs119482084 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15269-1; Sequence=Displayed; Name=2; IsoId=O15269-2; Sequence=VSP_043127, VSP_043128; Note=No experimental confirmation available.; 


uniprotID: Q96JX3
geneSymbol: SERAC1
name: Protein SERAC1 (Serine active site-containing protein 1)
length: 654
go: ENSG00000122335;
snps: rs201941476 rs17849527
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular matrix [GO:0031012]; integral component of membrane [GO:0016021]; Mitochondria-associated ER Membrane [GO:0044233]; mitochondrion [GO:0005739]; extracellular matrix organization [GO:0030198]; intracellular cholesterol transport [GO:0032367]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phospholipid biosynthetic process [GO:0008654]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96JX3-1; Sequence=Displayed; Name=2; IsoId=Q96JX3-2; Sequence=VSP_022859, VSP_022860; Name=3; IsoId=Q96JX3-3; Sequence=VSP_022857, VSP_022858; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:22683713}. Mitochondrion {ECO:0000269|PubMed:22683713}. Note=Localizes at the endoplasmic reticulum and at the endoplasmic reticulum-mitochondria interface.


uniprotID: Q8TB22
geneSymbol: SPATA20
name: Spermatogenesis-associated protein 20 (Sperm-specific protein 411) (Ssp411)
length: 786
go: ENSG00000006282;
snps: rs8076632 rs9913430 rs8065903
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; catalytic activity [GO:0003824]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8TB22-1; Sequence=Displayed; Name=2; IsoId=Q8TB22-2; Sequence=VSP_023290; Note=No experimental confirmation available.; Name=3; IsoId=Q8TB22-3; Sequence=VSP_023288; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; IsoId=Q8TB22-4; Sequence=VSP_023289, VSP_023291, VSP_023292; Note=No experimental confirmation available.; 


uniprotID: Q96DR4
geneSymbol: STARD4
reactome: R-HSA-196108;
name: StAR-related lipid transfer protein 4 (START domain-containing protein 4) (StARD4)
length: 205
go: ENSG00000164211;
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cholesterol binding [GO:0015485]; cholesterol transporter activity [GO:0017127]; cholesterol import [GO:0070508]; cholesterol transport involved in cholesterol storage [GO:0010879]; intracellular cholesterol transport [GO:0032367]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of cholesterol esterification [GO:0010873]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96DR4-1; Sequence=Displayed; Name=2; IsoId=Q96DR4-2; Sequence=VSP_057170; Note=No experimental confirmation available.; 


uniprotID: Q9NSY2
geneSymbol: STARD5
reactome: R-HSA-159418;
pdb: 2R55;
name: StAR-related lipid transfer protein 5 (START domain-containing protein 5) (StARD5)
length: 213
go: ENSG00000172345;
snps: rs4384572
sequence:

opentargets:
cytosol [GO:0005829]; bile acid binding [GO:0032052]; cholesterol binding [GO:0015485]; cholesterol transporter activity [GO:0017127]; bile acid and bile salt transport [GO:0015721]; cholesterol import [GO:0070508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NSY2-1; Sequence=Displayed; Name=2; IsoId=Q9NSY2-3; Sequence=VSP_014871, VSP_014872; Note=No experimental confirmation available.; 


uniprotID: Q9UBI4
geneSymbol: STOML1
length: 398
go: ENSG00000067221;
name:
Stomatin-like protein 1 (SLP-1) (EPB72-like protein 1) (Protein unc-24 homolog) (Stomatin-related protein) (STORP)

sequence:

opentargets:
integral component of membrane [GO:0016021]; late endosome membrane [GO:0031902]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; lipid transport [GO:0006869]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q9UBI4-1; Sequence=Displayed; Name=2; IsoId=Q9UBI4-2; Sequence=VSP_012654; Name=3; IsoId=Q9UBI4-3; Sequence=VSP_054649; Name=4; IsoId=Q9UBI4-4; Sequence=VSP_012654, VSP_054649; Note=No experimental confirmation available.; Name=5; IsoId=Q9UBI4-5; Sequence=VSP_054648, VSP_054649; Note=No experimental confirmation available.; Name=6; IsoId=Q9UBI4-6; Sequence=VSP_054649, VSP_054650; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:19696025}. Membrane raft {ECO:0000269|PubMed:19696025}. Cell membrane {ECO:0000250|UniProtKB:Q8CI66}; Single-pass type III membrane protein. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8CI66}.


uniprotID: Q9Y6Q2
geneSymbol: STON1
reactome: R-HSA-8856825;R-HSA-8856828;
name: Stonin-1 (Stoned B-like factor)
length: 735
go: ENSG00000068781;ENSG00000243244;
snps: rs17039250 rs940389 rs3828341 rs3792234
sequence:

opentargets:
cytoplasm [GO:0005737]; membrane [GO:0016020]; endocytosis [GO:0006897]; regulation of endocytosis [GO:0030100]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y6Q2-1; Sequence=Displayed; Name=2; IsoId=Q9Y6Q2-2; Sequence=VSP_045845; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=Q9Y6Q2-3; Sequence=VSP_045846; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11381094}. Membrane {ECO:0000269|PubMed:11381094}. Note=Some fraction is membrane-associated.


uniprotID: Q69YW2
geneSymbol: STUM
name: Protein stum homolog
length: 141
go: ENSG00000203685;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MEPSHKDAETAAAAAAVAAADPRGASSSSGVVVQVREKKGPLRAAIPYMPFPVAVICLFLNTFVPGLGTFVSAFTVLCGARTDLPDRHVCCVFWLNIAAALIQILTAIVMVGWIMSIFWGMDMVILAISQGYKEQGIPQQL


uniprotID: Q7Z7C7
geneSymbol: STRA8
name: Stimulated by retinoic acid gene 8 protein homolog
length: 330
go: ENSG00000146857;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein dimerization activity [GO:0046983]; cellular response to retinoic acid [GO:0071300]; DNA replication [GO:0006260]; male germ-line stem cell asymmetric division [GO:0048133]; meiotic cell cycle [GO:0051321]; oogenesis [GO:0048477]; positive regulation of transcription by RNA polymerase II [GO:0045944]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent. {ECO:0000250|UniProtKB:P70278}.


uniprotID: O95793
geneSymbol: STAU1
pdb: 4DKK;
name: Double-stranded RNA-binding protein Staufen homolog 1
length: 577
go: ENSG00000124214;
sequence:

opentargets:
cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; membrane [GO:0016020]; microtubule associated complex [GO:0005875]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; double-stranded RNA binding [GO:0003725]; protein phosphatase 1 binding [GO:0008157]; RNA binding [GO:0003723]; cellular response to oxidative stress [GO:0034599]; modification of postsynaptic structure [GO:0099010]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of viral genome replication [GO:0045070]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Long; IsoId=O95793-1; Sequence=Displayed; Name=Short; IsoId=O95793-2; Sequence=VSP_004434; Name=3; IsoId=O95793-3; Sequence=VSP_004434, VSP_043701; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19029303}. Rough endoplasmic reticulum {ECO:0000269|PubMed:19029303}. Note=Localizes exclusively with the rough reticulum endoplasmic (RER).


uniprotID: P84103
geneSymbol: SRSF3
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;
pdb: 2I2Y;2I38;
length: 164
go: ENSG00000112081;
name:
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)

sequence:
MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK

opentargets:
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA export from nucleus [GO:0006405]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P84103-1; Sequence=Displayed; Name=2; IsoId=P84103-2; Sequence=VSP_056243; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11336712}. Nucleus speckle {ECO:0000269|PubMed:26876937}. Cytoplasm {ECO:0000269|PubMed:11336712}. Note=Recruited to nuclear speckles following interaction with YTHDC1. {ECO:0000269|PubMed:26876937}.


uniprotID: Q08170
geneSymbol: SRSF4
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;
length: 494
go: ENSG00000116350;
snps: rs2230679 rs2230677 rs2230678 rs1049928
location: SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14578391}.
name:
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; sequence-specific mRNA binding [GO:1990825]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to insulin [GO:0032868]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]


uniprotID: P51571
geneSymbol: SSR4
reactome: R-HSA-1799339;
length: 173
go: ENSG00000180879;
snps: rs782018895
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
name:
Translocon-associated protein subunit delta (TRAP-delta) (Signal sequence receptor subunit delta) (SSR-delta)

sequence:
MAAMASLGALALLLLSSLSRCSAEACLEPQITPSYYTTSDAVISTETVFIVEISLTCKNRVQNMALYADVGGKQFPVTRGQDVGRYQVSWSLDHKSAHAGTYEVRFFDEESYSLLRKAQRNNEDISIIPPLFTVSVDHRGTWNGPWVSTEVLAAAIGLVIYYLAFSAKSHIQA

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; Sec61 translocon complex [GO:0005784]


uniprotID: O60224
geneSymbol: SSX4; SSX4B
name: Protein SSX4 (Cancer/testis antigen 5.4) (CT5.4)
length: 188
go: ENSG00000268009;ENSG00000269791;
sequence:
MNGDDAFARRPRDDAQISEKLRKAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEKINKTSGPKRGKHAWTHRLRERKQLVVYEEISDPEEDDE

opentargets:
nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60224-1; Sequence=Displayed; Name=2; IsoId=O60224-2; Sequence=VSP_054114, VSP_054115; Note=No experimental confirmation available.; 


uniprotID: Q6IMI4
geneSymbol: SULT6B1
reactome: R-HSA-156584;
name: Sulfotransferase 6B1 (ST6B1) (Thyroxine sulfotransferase) (EC 2.8.2.n2)
length: 303
snps: rs45552433 rs45626240 rs45493492 rs10205833 rs7425881 rs45439591 rs45495394
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q6IMI4-1; Sequence=Displayed; Name=2; IsoId=Q6IMI4-2; Sequence=VSP_013111; 


uniprotID: O43704
geneSymbol: SULT1B1
reactome: R-HSA-156584;
pdb: 2Z5F;3CKL;
length: 296
go: ENSG00000173597;
drug: DB01812;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Sulfotransferase family cytosolic 1B member 1 (ST1B1) (Sulfotransferase 1B1) (EC 2.8.2.-) (Sulfotransferase 1B2) (ST1B2) (Thyroid hormone sulfotransferase)

sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cellular biogenic amine metabolic process [GO:0006576]; epithelial cell differentiation [GO:0030855]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; thyroid hormone metabolic process [GO:0042403]; xenobiotic metabolic process [GO:0006805]


uniprotID: Q9UJ98
geneSymbol: STAG3
reactome: R-HSA-1221632;
name: Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3)
length: 1225
go: ENSG00000066923;
sequence:

opentargets:
chromosome, centromeric region [GO:0000775]; extracellular space [GO:0005615]; meiotic cohesin complex [GO:0030893]; nucleus [GO:0005634]; synaptonemal complex [GO:0000795]; synaptonemal complex assembly [GO:0007130]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UJ98-1; Sequence=Displayed; Name=2; IsoId=Q9UJ98-2; Sequence=VSP_006996, VSP_006997; Note=No experimental confirmation available.; Name=3; IsoId=Q9UJ98-3; Sequence=VSP_054742; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750, ECO:0000269|PubMed:12034751}. Chromosome {ECO:0000269|PubMed:12034751}. Chromosome, centromere {ECO:0000269|PubMed:12034751}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation. {ECO:0000269|PubMed:12034751}.


uniprotID: Q92783
geneSymbol: STAM
reactome: R-HSA-182971;R-HSA-5689901;R-HSA-6807004;R-HSA-8856825;R-HSA-8856828;R-HSA-8875360;R-HSA-917729;
pdb: 2L0A;3F1I;3LDZ;
name: Signal transducing adapter molecule 1 (STAM-1)
length: 540
go: ENSG00000136738;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome membrane [GO:0031901]; ESCRT-0 complex [GO:0033565]; SH3/SH2 adaptor activity [GO:0005070]; ubiquitin-like protein ligase binding [GO:0044389]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; membrane organization [GO:0061024]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; positive regulation of exosomal secretion [GO:1903543]; protein deubiquitination [GO:0016579]; regulation of extracellular exosome assembly [GO:1903551]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92783-1; Sequence=Displayed; Name=2; IsoId=Q92783-2; Sequence=VSP_014846, VSP_014847; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:23166352, ECO:0000269|PubMed:24790097}; Peripheral membrane protein {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}; Cytoplasmic side {ECO:0000305|PubMed:23166352, ECO:0000305|PubMed:24790097}.


uniprotID: E0CX11
geneSymbol: STMP1
name: Short transmembrane mitochondrial protein 1
sequence: MLQFLLGFTLGNVVGMYLAQNYDIPNLAKKLEEIKKDLDAKKKPPSA
length: 47
go: ENSG00000243317;
opentargets: integral component of membrane [GO:0016021]; mitochondrial membrane [GO:0031966]
location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000255}.


uniprotID: P31948
geneSymbol: STIP1
reactome: R-HSA-3371497;
pdb: 1ELR;1ELW;2LNI;2NC9;3ESK;3FWV;
length: 543
go: ENSG00000168439;
name:
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)

sequence:

opentargets:
chaperone complex [GO:0101031]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chaperone binding [GO:0051087]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; protein C-terminus binding [GO:0008022]; RNA binding [GO:0003723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P31948-1; Sequence=Displayed; Name=2; IsoId=P31948-2; Sequence=VSP_055034; Name=3; IsoId=P31948-3; Sequence=VSP_055035; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60864}. Nucleus {ECO:0000250|UniProtKB:Q60864}.


uniprotID: Q8IWL8
geneSymbol: STH
name: Saitohin
length: 128
go: ENSG00000256762;
snps: rs62063857
sequence:
MSEGGGQVSCIFAAPTRLCRWPALIECGVNLTQPLCEWMIQVARDRTLSLAWEVASLLTLSSSEVGLEGVGTIWPSSYSSEESSRNGAEQGRQLSIEGPFQGQNCPSHPAAALPLPMRGESQATSCQV

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16186110}. Nucleus {ECO:0000269|PubMed:16186110}.


uniprotID: O94804
geneSymbol: STK10
reactome: R-HSA-6798695;
pdb: 2J7T;4AOT;4BC6;4EQU;4USD;4USE;5AJQ;5OWQ;5OWR;6EIM;6GTT;
name: Serine/threonine-protein kinase 10 (EC 2.7.11.1) (Lymphocyte-oriented kinase)
length: 968
go: ENSG00000072786;
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; cell cycle [GO:0007049]; lymphocyte aggregation [GO:0071593]; neutrophil degranulation [GO:0043312]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of lymphocyte migration [GO:2000401]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

snps:
rs35826078 rs757545210 rs56214442 rs55972616 rs56063773 rs34505340 rs17074311 rs34936670 rs56066852 rs55791916 rs1128204 rs56355550 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19255442}; Peripheral membrane protein {ECO:0000269|PubMed:19255442}.


uniprotID: P08842
geneSymbol: STS
reactome: R-HSA-1660662;R-HSA-1663150;
pdb: 1P49;
length: 583
go: ENSG00000101846;
drug: DB02735;DB06713;
snps: rs137853167 rs137853165 rs137853168 rs137853169 rs137853166
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
name:
Steryl-sulfatase (EC 3.1.6.2) (Arylsulfatase C) (ASC) (Steroid sulfatase) (Steryl-sulfate sulfohydrolase)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; membrane [GO:0016020]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; steryl-sulfatase activity [GO:0004773]; sulfuric ester hydrolase activity [GO:0008484]; epidermis development [GO:0008544]; female pregnancy [GO:0007565]; glycosphingolipid metabolic process [GO:0006687]; steroid catabolic process [GO:0006706]


uniprotID: Q9NRL3
geneSymbol: STRN4
name: Striatin-4 (Zinedin)
length: 753
go: ENSG00000090372;
snps: rs10409124
sequence:

opentargets:
cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NRL3-1; Sequence=Displayed; Name=2; IsoId=Q9NRL3-2; Sequence=VSP_056170, VSP_056171, VSP_056172; Note=No experimental confirmation available.; Name=3; IsoId=Q9NRL3-3; Sequence=VSP_056738; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.


uniprotID: Q9H6E5
geneSymbol: TUT1
pdb: 2E5G;5WU1;5WU2;5WU3;5WU4;5WU5;5WU6;
length: 874
go: ENSG00000149016;
snps: rs3197865
name:
Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; mRNA 3'-UTR binding [GO:0003730]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; RNA uridylyltransferase activity [GO:0050265]; mRNA polyadenylation [GO:0006378]; pre-mRNA cleavage required for polyadenylation [GO:0098789]; snRNA processing [GO:0016180]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16790842}. Nucleus speckle {ECO:0000269|PubMed:18288197, ECO:0000269|PubMed:18305108}.


uniprotID: O00506
geneSymbol: STK25
pdb: 2XIK;3W8H;4NZW;
length: 426
go: ENSG00000115694;
snps: rs34341643
name:
Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; establishment of Golgi localization [GO:0051683]; establishment or maintenance of cell polarity [GO:0007163]; Golgi localization [GO:0051645]; Golgi reassembly [GO:0090168]; intrinsic apoptotic signaling pathway in response to hydrogen peroxide [GO:0036481]; positive regulation of axonogenesis [GO:0050772]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; response to hydrogen peroxide [GO:0042542]; response to oxidative stress [GO:0006979]; signal transduction [GO:0007165]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O00506-1; Sequence=Displayed; Name=2; IsoId=O00506-2; Sequence=VSP_054397; Note=No experimental confirmation available.; Name=3; IsoId=O00506-3; Sequence=VSP_054683; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15037601}. Golgi apparatus {ECO:0000269|PubMed:15037601}. Note=Localizes to the Golgi apparatus.


uniprotID: Q8TDR2
geneSymbol: STK35
length: 534
go: ENSG00000125834;
name:
Serine/threonine-protein kinase 35 (EC 2.7.11.1) (CLP-36-interacting kinase 1) (CLIK-1) (PDLIM1-interacting kinase 1) (Serine/threonine-protein kinase 35 L1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; meiotic cell cycle [GO:0051321]

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Cytoplasm. Note=When associated with PDLIM1, it is mostly found in cytoplasm, localized to actin stress fibers (PubMed:11973348). However, PubMed:19756140 detected STK35 only in the nucleus, and the presence of PDLIM1 had no influence on its location. {ECO:0000269|PubMed:11973348}.


uniprotID: Q9P2R7
geneSymbol: SUCLA2
reactome: R-HSA-71403;
pdb: 6G4Q;
length: 463
go: ENSG00000136143;
drug: DB00139;
snps: rs35201084 rs121908537 rs7320366 rs397515462 rs121908538
name:
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)

sequence:

opentargets:
extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; succinate-CoA ligase (ADP-forming) activity [GO:0004775]; succinate metabolic process [GO:0006105]; succinyl-CoA metabolic process [GO:0006104]; succinyl-CoA pathway [GO:0006781]; tricarboxylic acid cycle [GO:0006099]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P2R7-1; Sequence=Displayed; Name=2; IsoId=Q9P2R7-2; Sequence=VSP_006292; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03220, ECO:0000269|PubMed:15877282, ECO:0000269|PubMed:17287286, ECO:0000269|PubMed:25944712}.


uniprotID: P17947
geneSymbol: SPI1
reactome: R-HSA-8939236;
name: Transcription factor PU.1 (31 kDa-transforming protein)
length: 270
go: ENSG00000066336;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:23166356}.
sequence:

opentargets:
nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001205]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; NFAT protein binding [GO:0051525]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA binding [GO:0003723]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; anatomical structure regression [GO:0060033]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; cell differentiation [GO:0030154]; cellular response to ethanol [GO:0071361]; erythrocyte differentiation [GO:0030218]; granulocyte differentiation [GO:0030851]; histone H3 acetylation [GO:0043966]; hypermethylation of CpG island [GO:0044027]; lymphocyte differentiation [GO:0030098]; lymphoid progenitor cell differentiation [GO:0002320]; macrophage differentiation [GO:0030225]; myeloid dendritic cell differentiation [GO:0043011]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of histone H4 acetylation [GO:0090241]; negative regulation of MHC class II biosynthetic process [GO:0045347]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; pri-miRNA transcription by RNA polymerase II [GO:0061614]; regulation of erythrocyte differentiation [GO:0045646]; regulation of transcription by RNA polymerase II [GO:0006357]; somatic stem cell population maintenance [GO:0035019]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P17947-1; Sequence=Displayed; Name=2; IsoId=P17947-2; Sequence=VSP_038690; 


uniprotID: B3KS81
geneSymbol: SRRM5
name: Serine/arginine repetitive matrix protein 5
length: 715
go: ENSG00000226763;
sequence:


uniprotID: Q9BWG4
geneSymbol: SSBP4
name: Single-stranded DNA-binding protein 4
length: 385
go: ENSG00000130511;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BWG4-1; Sequence=Displayed; Name=2; IsoId=Q9BWG4-2; Sequence=VSP_054113; 


uniprotID: P09132
geneSymbol: SRP19
reactome: R-HSA-1799339;
pdb: 1JID;1MFQ;1RY1;2J37;3KTV;4P3E;5M73;
name: Signal recognition particle 19 kDa protein (SRP19)
length: 144
go: ENSG00000153037;
snps: rs17855423
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:
MACAAARSPADQDRFICIYPAYLNNKKTIAEGRRIPISKAVENPTATEIQDVCSAVGLNVFLEKNKMYSREWNRDVQYRGRVRVQLKQEDGSLCLVQFPSRKSVMLYAAEMIPKLKTRTQKTGGADQSLQQGEGSKKGKGKKKK

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; cotranslational protein targeting to membrane [GO:0006613]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P09132-1; Sequence=Displayed; Name=2; IsoId=P09132-2; Sequence=VSP_042540; Note=No experimental confirmation available.; Name=3; IsoId=P09132-3; Sequence=VSP_044524; 


uniprotID: Q9UQ35
geneSymbol: SRRM2
reactome: R-HSA-72163;
pdb: 5MQF;5XJC;5YZG;5Z56;5Z57;6FF4;
length: 2752
go: ENSG00000167978;
snps: rs2240140 rs12185191 rs17136053
location: SUBCELLULAR LOCATION: Nucleus speckle.
name:
Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)

sequence:

opentargets:
Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U2-type catalytic step 2 spliceosome [GO:0071007]; C2H2 zinc finger domain binding [GO:0070742]; protein N-terminus binding [GO:0047485]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UQ35-1; Sequence=Displayed; Name=2; IsoId=Q9UQ35-2; Sequence=VSP_020187; Note=No experimental confirmation available.; Name=3; IsoId=Q9UQ35-3; Sequence=VSP_020184, VSP_020185, VSP_020186; Note=No experimental confirmation available.; 


uniprotID: Q14140
geneSymbol: SERTAD2
length: 314
go: ENSG00000179833;
name:
SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; negative regulation of cell growth [GO:0030308]; positive regulation of transcription, DNA-templated [GO:0045893]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18316374}. Cytoplasm {ECO:0000269|PubMed:18316374}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.


uniprotID: Q9Y2M2
geneSymbol: SSUH2
name: Protein SSUH2 homolog (Protein ssu-2 homolog)
length: 353
go: ENSG00000125046;
opentargets: cytoplasm [GO:0005737]; nucleus [GO:0005634]; odontogenesis [GO:0042476]
snps: rs2276800 rs140981580
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2M2-1; Sequence=Displayed; Name=2; IsoId=Q9Y2M2-2; Sequence=VSP_046355; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20205943}. Nucleus {ECO:0000269|PubMed:27680507}.


uniprotID: Q9Y365
geneSymbol: STARD10
reactome: R-HSA-1483191;
length: 291
go: ENSG00000214530;
name:
START domain-containing protein 10 (StARD10) (Antigen NY-CO-28) (PCTP-like protein) (PCTP-L) (Serologically defined colon cancer antigen 28) (StAR-related lipid transfer protein 10)

sequence:

opentargets:
cytosol [GO:0005829]; intercellular canaliculus [GO:0046581]; membrane [GO:0016020]; microvillus [GO:0005902]; motile cilium [GO:0031514]; lipid binding [GO:0008289]; bile acid secretion [GO:0032782]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid transport [GO:0015914]; positive regulation of peroxisome proliferator activated receptor signaling pathway [GO:0035360]

location:
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:17561512}. Membrane {ECO:0000269|PubMed:17561512}. Note=In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic. {ECO:0000250}.


uniprotID: Q99909
geneSymbol: SSX3
name: Protein SSX3 (Cancer/testis antigen 5.3) (CT5.3)
length: 188
go: ENSG00000165584;
sequence:
MNGDDTFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKVSEKIVYVYMKRKYEAMTKLGFKAILPSFMRNKRVTDFQGNDFDNDPNRGNQVQRPQMTFGRLQGIFPKIMPKKPAEEGNVSKEVPEASGPQNDGKQLCPPGKPTTSEKINMISGPKRGEHAWTHRLRERKQLVIYEEISDPEEDDE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99909-1; Sequence=Displayed; Name=2; IsoId=Q99909-2; Sequence=VSP_042777; Note=No experimental confirmation available.; 


uniprotID: Q7RTT4
geneSymbol: SSX8
name: Protein SSX8
length: 187
sequence:
MNGDDAFAKRPRDDDKASEKRSKAFNDIATYFSKKEWEKMKYSEKISYVYMKRNYEAMTKLGFNVTLPPFMCNKQATDFQGNYFDNDRNRRIQVERPQMTFGRLQRIIPKIMPKKPAEEGNDSKGVSEASGPQNDGKQLAPGKANTSEKINKRSGPKRGRHAWTHRLRERNQLVIYEEIRDPEEDDE


uniprotID: Q7RTT3
geneSymbol: SSX9
name: Protein SSX9
length: 188
snps: rs4598385 rs6609702
sequence:
MNGDDAFARRPRAGSQIPEKIQKAFDDIAKYFSKKEWEKMKSSEKIIYVYMKRKYEAMTKLGFKATLPPFMCNTGATDLQGNDFDNDRNHRNQVERSQMTFGRLQGIFPKIMPKKPAEVGNDSKEVPEASGLQNDGKQLCPPGKPTTSEKINKASGPKRGKHAWTHRLRERKQLVIYEEISDPEEDDE


uniprotID: Q8N412
geneSymbol: STPG2
name: Sperm-tail PG-rich repeat-containing protein 2
length: 459
go: ENSG00000163116;
snps: rs13131259 rs13131258 rs17558193 rs2903150 rs7654193 rs17026871
sequence:


uniprotID: Q13188
geneSymbol: STK3
reactome: R-HSA-2028269;
pdb: 3WWS;4HKD;4L0N;4LG4;4LGD;4OH9;5BRM;5DH3;6AO5;
length: 491
go: ENSG00000104375;
snps: rs36047674
name:
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein dimerization activity [GO:0046983]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; cell differentiation involved in embryonic placenta development [GO:0060706]; central nervous system development [GO:0007417]; endocardium development [GO:0003157]; hepatocyte apoptotic process [GO:0097284]; hippo signaling [GO:0035329]; intracellular signal transduction [GO:0035556]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation [GO:0008285]; negative regulation of organ growth [GO:0046621]; neural tube formation [GO:0001841]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase B signaling [GO:0051897]; primitive hemopoiesis [GO:0060215]; protein phosphorylation [GO:0006468]; protein stabilization [GO:0050821]; regulation of cell differentiation involved in embryonic placenta development [GO:0060800]; signal transduction [GO:0007165]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13188-1; Sequence=Displayed; Name=2; IsoId=Q13188-2; Sequence=VSP_054167; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=The caspase-cleaved form cycles between nucleus and cytoplasm (By similarity). Phosphorylation at Thr-117 leads to inhibition of nuclear translocation. {ECO:0000250, ECO:0000269|PubMed:19525978}.


uniprotID: Q14849
geneSymbol: STARD3
reactome: R-HSA-196108;
pdb: 1EM2;2I92;5I9J;
length: 445
go: ENSG00000131748;
snps: rs1877031 rs11556624
name:
StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; organelle membrane contact site [GO:0044232]; cholesterol binding [GO:0015485]; cholesterol transporter activity [GO:0017127]; protein homodimerization activity [GO:0042803]; C21-steroid hormone biosynthetic process [GO:0006700]; cholesterol metabolic process [GO:0008203]; cholesterol transport [GO:0030301]; lipid metabolic process [GO:0006629]; mitochondrial transport [GO:0006839]; progesterone biosynthetic process [GO:0006701]; steroid metabolic process [GO:0008202]; vesicle tethering to endoplasmic reticulum [GO:0099044]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q14849-1; Sequence=Displayed; Name=2; IsoId=Q14849-2; Sequence=VSP_042710; Note=No experimental confirmation available.; Name=3; IsoId=Q14849-3; Sequence=VSP_045361; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11053434, ECO:0000269|PubMed:16709157, ECO:0000269|PubMed:24105263, ECO:0000269|PubMed:28377464}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB (PubMed:24105263). {ECO:0000269|PubMed:24105263}.


uniprotID: P46977
geneSymbol: STT3A
reactome: R-HSA-446203;
length: 705
go: ENSG00000134910;
snps: rs587777216
name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (Oligosaccharyl transferase subunit STT3A) (STT3-A) (EC 2.4.99.18) (B5) (Integral membrane protein 1) (Transmembrane protein TMC)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; oligosaccharyltransferase III complex [GO:0035000]; dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; metal ion binding [GO:0046872]; co-translational protein modification [GO:0043686]; protein N-linked glycosylation via asparagine [GO:0018279]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P46977-1; Sequence=Displayed; Name=2; IsoId=P46977-2; Sequence=VSP_055106; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:12887896}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P46978}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P46978}.


uniprotID: Q8N3U4
geneSymbol: STAG2
reactome: R-HSA-1221632;R-HSA-2467813;R-HSA-2468052;R-HSA-2470946;R-HSA-2500257;R-HSA-3108214;R-HSA-9018519;
pdb: 4PJU;4PJW;4PK7;
name: Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2)
length: 1231
go: ENSG00000101972;
snps: rs6655782
sequence:

opentargets:
chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; membrane [GO:0016020]; mitotic spindle pole [GO:0097431]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell division [GO:0051301]; meiotic cell cycle [GO:0051321]; negative regulation of DNA endoreduplication [GO:0032876]; regulation of mitotic spindle assembly [GO:1901673]; sister chromatid cohesion [GO:0007062]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N3U4-1; Sequence=Displayed; Name=2; IsoId=Q8N3U4-2; Sequence=VSP_041119; 

location:
SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.


uniprotID: P49675
geneSymbol: STAR
reactome: R-HSA-196108;
pdb: 1IMG;2I93;3P0L;5OMA;
length: 285
go: ENSG00000147465;
snps: rs34908868 rs747169620 rs104894086 rs1042854 rs137852689 rs137852690 rs762245736
location: SUBCELLULAR LOCATION: Mitochondrion.
name:
Steroidogenic acute regulatory protein, mitochondrial (StAR) (START domain-containing protein 1) (StARD1)

sequence:

opentargets:
cytosol [GO:0005829]; mitochondrial crista [GO:0030061]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; cholesterol binding [GO:0015485]; cholesterol transporter activity [GO:0017127]; bile acid biosynthetic process [GO:0006699]; biphenyl metabolic process [GO:0018879]; brain development [GO:0007420]; C21-steroid hormone biosynthetic process [GO:0006700]; cellular response to alkaloid [GO:0071312]; cellular response to antibiotic [GO:0071236]; cellular response to cadmium ion [GO:0071276]; cellular response to cAMP [GO:0071320]; cellular response to dexamethasone stimulus [GO:0071549]; cellular response to epinephrine stimulus [GO:0071872]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to glucose stimulus [GO:0071333]; cellular response to growth hormone stimulus [GO:0071378]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-alpha [GO:0035457]; cellular response to interferon-gamma [GO:0071346]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to luteinizing hormone stimulus [GO:0071373]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cholesterol metabolic process [GO:0008203]; circadian sleep/wake cycle, REM sleep [GO:0042747]; dibenzo-p-dioxin metabolic process [GO:0018894]; diterpenoid metabolic process [GO:0016101]; estrogen biosynthetic process [GO:0006703]; glucocorticoid metabolic process [GO:0008211]; insecticide metabolic process [GO:0017143]; intracellular cholesterol transport [GO:0032367]; male gonad development [GO:0008584]; negative regulation of neuron apoptotic process [GO:0043524]; phenol-containing compound metabolic process [GO:0018958]; phthalate metabolic process [GO:0018963]; positive regulation of bile acid biosynthetic process [GO:0070859]; positive regulation of gene expression [GO:0010628]; positive regulation of neurogenesis [GO:0050769]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of steroid biosynthetic process [GO:0050810]; response to activity [GO:0014823]; response to corticosterone [GO:0051412]; response to estrogen [GO:0043627]; response to ethanol [GO:0045471]; response to fungicide [GO:0060992]; response to herbicide [GO:0009635]; response to hydrogen peroxide [GO:0042542]; response to ionizing radiation [GO:0010212]; response to lead ion [GO:0010288]; response to leptin [GO:0044321]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; steroid biosynthetic process [GO:0006694]; testosterone biosynthetic process [GO:0061370]


uniprotID: Q5VSL9
geneSymbol: STRIP1
name: Striatin-interacting protein 1 (Protein FAM40A)
length: 837
go: ENSG00000143093;
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; Rho GTPase binding [GO:0017048]; cortical actin cytoskeleton organization [GO:0030866]; regulation of cell morphogenesis [GO:0022604]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5VSL9-1; Sequence=Displayed; Name=2; IsoId=Q5VSL9-2; Sequence=VSP_014857; Note=No experimental confirmation available.; Name=3; IsoId=Q5VSL9-3; Sequence=VSP_014856, VSP_014860, VSP_014861, VSP_014862; Note=No experimental confirmation available.; Name=4; IsoId=Q5VSL9-4; Sequence=VSP_014858, VSP_014859; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21834987}. Note=Enriched on the plasma membrane.


uniprotID: Q658P3
geneSymbol: STEAP3
reactome: R-HSA-6803204;R-HSA-917977;
pdb: 2VNS;2VQ3;
length: 488
go: ENSG00000115107;
snps: rs17013371
name:
Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)

sequence:

opentargets:
cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; multivesicular body [GO:0005771]; plasma membrane [GO:0005886]; cupric reductase activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [GO:0016723]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; copper ion import [GO:0015677]; ferric iron import across cell outer membrane [GO:0098706]; iron ion homeostasis [GO:0055072]; oxidation-reduction process [GO:0055114]; protein secretion [GO:0009306]; regulation of apoptotic process [GO:0042981]; transferrin transport [GO:0033572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q658P3-1; Sequence=Displayed; Name=2; IsoId=Q658P3-2; Sequence=VSP_024829; Name=3; IsoId=Q658P3-3; Sequence=VSP_024830; Name=4; Synonyms=pHyde II; IsoId=Q658P3-4; Sequence=VSP_024830, VSP_024831; 

location:
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus.


uniprotID: Q8N4C7
geneSymbol: STX19
name: Syntaxin-19
length: 294
go: ENSG00000178750;
sequence:

opentargets:
endomembrane system [GO:0012505]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R1Q0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1Q0}. Cytoplasm {ECO:0000250|UniProtKB:Q8R1Q0}.


uniprotID: Q9BYT3
geneSymbol: STK33
name: Serine/threonine-protein kinase 33 (EC 2.7.11.1)
length: 514
go: ENSG00000130413;
snps: rs60786172 rs34525052 rs3751096 rs3751095 rs35296353
location: SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; mitotic DNA damage checkpoint [GO:0044773]; protein autophosphorylation [GO:0046777]; signal transduction in response to DNA damage [GO:0042770]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BYT3-1; Sequence=Displayed; Name=2; IsoId=Q9BYT3-2; Sequence=VSP_017939; Note=No experimental confirmation available.; 


uniprotID: Q9Y2K9
geneSymbol: STXBP5L
name: Syntaxin-binding protein 5-like (Lethal(2) giant larvae protein homolog 4) (Tomosyn-2)
length: 1186
go: ENSG00000145087;
snps: rs17249244 rs17740066
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; neuromuscular junction [GO:0031594]; neuronal dense core vesicle [GO:0098992]; plasma membrane [GO:0005886]; SNARE complex [GO:0031201]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; syntaxin binding [GO:0019905]; exocytosis [GO:0006887]; glucose homeostasis [GO:0042593]; negative regulation of insulin secretion [GO:0046676]; protein transport [GO:0015031]; regulation of exocytosis [GO:0017157]; regulation of synaptic vesicle exocytosis [GO:2000300]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2K9-1; Sequence=Displayed; Name=2; IsoId=Q9Y2K9-2; Sequence=VSP_016293, VSP_016294; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. {ECO:0000305}.


uniprotID: Q15208
geneSymbol: STK38
pdb: 1PSB;6BXI;
length: 465
go: ENSG00000112079;
snps: rs56005153 rs56105564
location: SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
name:
Serine/threonine-protein kinase 38 (EC 2.7.11.1) (NDR1 protein kinase) (Nuclear Dbf2-related kinase 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; magnesium ion binding [GO:0000287]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein serine/threonine kinase activity [GO:0004674]; cellular protein modification process [GO:0006464]; intracellular signal transduction [GO:0035556]; negative regulation of MAP kinase activity [GO:0043407]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]


uniprotID: Q01130
geneSymbol: SRSF2
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72165;R-HSA-72187;
pdb: 2KN4;2LEA;2LEB;2LEC;
length: 221
go: ENSG00000161547;
name:
Serine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; transcription corepressor activity [GO:0003714]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q01130-1; Sequence=Displayed; Name=2; IsoId=Q01130-2; Sequence=VSP_056153; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21157427}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21157427}. Nucleus speckle {ECO:0000269|PubMed:21157427}. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.


uniprotID: Q8WYL5
geneSymbol: SSH1
length: 1049
go: ENSG00000084112;
name:
Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)

sequence:

opentargets:
cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; midbody [GO:0030496]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; actin cytoskeleton organization [GO:0030036]; cell morphogenesis [GO:0000902]; cellular response to ATP [GO:0071318]; excitatory chemical synaptic transmission [GO:0098976]; positive regulation of AMPA glutamate receptor clustering [GO:1904719]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neuron death [GO:1901216]; positive regulation of synaptic plasticity [GO:0031915]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; protein dephosphorylation [GO:0006470]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of cellular protein metabolic process [GO:0032268]; regulation of lamellipodium assembly [GO:0010591]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=L; IsoId=Q8WYL5-1; Sequence=Displayed; Name=2; Synonyms=S; IsoId=Q8WYL5-2; Sequence=VSP_016318, VSP_016319; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=B; IsoId=Q8WYL5-3; Sequence=VSP_016312, VSP_016314, VSP_016315, VSP_016316; Note=Due to intron retention. No experimental confirmation available.; Name=4; IsoId=Q8WYL5-4; Sequence=VSP_016311, VSP_016317; Name=5; IsoId=Q8WYL5-5; Sequence=VSP_016313, VSP_016318, VSP_016319; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.


uniprotID: O75494
geneSymbol: SRSF10
reactome: R-HSA-72163;
length: 262
go: ENSG00000188529;
name:
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]; cytosolic transport [GO:0016482]; mRNA 5'-splice site recognition [GO:0000395]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of mRNA splicing, via spliceosome [GO:0048024]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing, via transesterification reactions [GO:0000375]; spliceosomal tri-snRNP complex assembly [GO:0000244]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=TASR-1; IsoId=O75494-1; Sequence=Displayed; Name=2; IsoId=O75494-2; Sequence=VSP_010421; Name=3; Synonyms=TASR-2, SRp38-2; IsoId=O75494-3; Sequence=VSP_010424, VSP_010425; Name=4; IsoId=O75494-4; Sequence=VSP_010422, VSP_010423, VSP_010425; Name=5; IsoId=O75494-5; Sequence=VSP_043697, VSP_043698, VSP_010423, VSP_010425; Note=No experimental confirmation available.; Name=6; IsoId=O75494-6; Sequence=VSP_010421, VSP_010424, VSP_010425; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:11684676, ECO:0000269|PubMed:26876937}. Cytoplasm {ECO:0000269|PubMed:11684676}.


uniprotID: Q8WU08
geneSymbol: STK32A
pdb: 4FR4;
name: Serine/threonine-protein kinase 32A (EC 2.7.11.1) (Yet another novel kinase 1)
length: 396
go: ENSG00000169302;
snps: rs35852718
location: SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor {ECO:0000269|PubMed:25043870}.
sequence:

opentargets:
intracellular [GO:0005622]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000305}; IsoId=Q8WU08-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=Q8WU08-2; Sequence=VSP_051992, VSP_051993; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000305}; IsoId=Q8WU08-3; Sequence=VSP_051994, VSP_051995; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q9UEE5
geneSymbol: STK17A
length: 414
go: ENSG00000164543;
snps: rs56286238 rs35940029 rs3779062 rs1044141
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9786912}.
name:
Serine/threonine-protein kinase 17A (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 1)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of apoptotic process [GO:0043065]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein phosphorylation [GO:0006468]; regulation of reactive oxygen species metabolic process [GO:2000377]


uniprotID: P0CL84
geneSymbol: STAG3L2
name: Putative STAG3-like protein 2 (Stromal antigen 3-like protein 2)
length: 134
opentargets: nucleus [GO:0005634]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
sequence:
MIFSMLRKLPKVTCRDVLPEIRAICIEEIGCWMQSYSTSFLTDSYLKYIGWTLHDKHREVRVKCVKALKGLYGNRDLTARLELFTGRFKDWMVSMIVDREYSVAVEAVRLLILILKNMEGVLMDVDCESVYPIV

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P0CL84-1; Sequence=Displayed; Name=2; IsoId=P0CL84-2; Sequence=VSP_041015; 


uniprotID: Q9BR01
geneSymbol: SULT4A1
reactome: R-HSA-156584;
pdb: 1ZD1;
length: 284
go: ENSG00000130540;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Sulfotransferase 4A1 (ST4A1) (EC 2.8.2.-) (Brain sulfotransferase-like protein) (hBR-STL) (hBR-STL-1) (Nervous system sulfotransferase) (NST)

sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; identical protein binding [GO:0042802]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; steroid metabolic process [GO:0008202]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BR01-1; Sequence=Displayed; Name=2; IsoId=Q9BR01-2; Sequence=VSP_006304; 


uniprotID: P50226
geneSymbol: SULT1A2
reactome: R-HSA-156584;
pdb: 1Z29;
length: 295
go: ENSG00000197165;
snps: rs1136703 rs10797300 rs4987024 rs1059491 rs45472392 rs27742
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Sulfotransferase 1A2 (ST1A2) (EC 2.8.2.1) (Aryl sulfotransferase 2) (Phenol sulfotransferase 2) (Phenol-sulfating phenol sulfotransferase 2) (P-PST 2)

sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine biosynthetic process [GO:0009309]; catecholamine metabolic process [GO:0006584]; ethanol catabolic process [GO:0006068]; phenol-containing compound metabolic process [GO:0018958]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]


uniprotID: P0DMM9
geneSymbol: SULT1A3
reactome: R-HSA-156584;R-HSA-381038;
pdb: 1CJM;2A3R;
length: 295
go: ENSG00000261052;
snps: rs751527244 rs1293732453 rs1328799050
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Sulfotransferase 1A3 (ST1A3) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Catecholamine-sulfating phenol sulfotransferase) (HAST3) (M-PST) (Monoamine-sulfating phenol sulfotransferase) (Placental estrogen sulfotransferase) (Sulfotransferase 1A3/1A4) (Sulfotransferase, monoamine-preferring) (Thermolabile phenol sulfotransferase) (TL-PST)

sequence:

opentargets:
cytosol [GO:0005829]; amine sulfotransferase activity [GO:0047685]; aryl sulfotransferase activity [GO:0004062]; sulfate binding [GO:0043199]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; calcineurin-mediated signaling [GO:0097720]; cellular response to dopamine [GO:1903351]; dopamine catabolic process [GO:0042420]; dopamine receptor signaling pathway [GO:0007212]; ERK1 and ERK2 cascade [GO:0070371]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of neuron death [GO:1901215]; NMDA selective glutamate receptor signaling pathway [GO:0098989]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P0DMM9-1; Sequence=Displayed; Name=2; IsoId=P0DMM9-2; Sequence=VSP_012326; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=P0DMM9-3; Sequence=VSP_047771; 


uniprotID: Q8TDW4
geneSymbol: ST7L
name: Suppressor of tumorigenicity 7 protein-like (ST7-related protein)
length: 575
go: ENSG00000007341;
opentargets: integral component of membrane [GO:0016021]; negative regulation of cell growth [GO:0030308]
snps: rs6658555 rs3736764 rs12069022
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q8TDW4-1; Sequence=Displayed; Name=2; IsoId=Q8TDW4-2; Sequence=VSP_034131; Name=3; IsoId=Q8TDW4-3; Sequence=VSP_034129; Name=4; IsoId=Q8TDW4-4; Sequence=VSP_034127; Note=No experimental confirmation available.; Name=5; IsoId=Q8TDW4-5; Sequence=VSP_034134, VSP_034135; Name=6; IsoId=Q8TDW4-6; Sequence=VSP_034129, VSP_034134, VSP_034135; Name=7; IsoId=Q8TDW4-7; Sequence=VSP_034133, VSP_034136; Name=8; IsoId=Q8TDW4-8; Sequence=VSP_034128, VSP_034130, VSP_034132; Note=No experimental confirmation available.; 


uniprotID: P51692
geneSymbol: STAT5B
name: Signal transducer and activator of transcription 5B
length: 787
go: ENSG00000173757;
drug: DB01254;
snps: rs2277619 rs121908501
reactome:
R-HSA-1170546;R-HSA-1266695;R-HSA-1433557;R-HSA-1839117;R-HSA-186763;R-HSA-2586552;R-HSA-512988;R-HSA-8854691;R-HSA-8983432;R-HSA-8985947;R-HSA-9020558;R-HSA-9020958;R-HSA-982772;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; glucocorticoid receptor binding [GO:0035259]; protein dimerization activity [GO:0046983]; protein tyrosine kinase activity [GO:0004713]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; 2-oxoglutarate metabolic process [GO:0006103]; allantoin metabolic process [GO:0000255]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to growth factor stimulus [GO:0071363]; cellular response to hormone stimulus [GO:0032870]; citrate metabolic process [GO:0006101]; creatine metabolic process [GO:0006600]; creatinine metabolic process [GO:0046449]; cytokine-mediated signaling pathway [GO:0019221]; development of secondary female sexual characteristics [GO:0046543]; development of secondary male sexual characteristics [GO:0046544]; fatty acid metabolic process [GO:0006631]; female pregnancy [GO:0007565]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; isoleucine metabolic process [GO:0006549]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lactation [GO:0007595]; lipid storage [GO:0019915]; luteinization [GO:0001553]; mast cell migration [GO:0097531]; natural killer cell differentiation [GO:0001779]; negative regulation of apoptotic process [GO:0043066]; negative regulation of erythrocyte differentiation [GO:0045647]; oxaloacetate metabolic process [GO:0006107]; Peyer's patch development [GO:0048541]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of gamma-delta T cell differentiation [GO:0045588]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interleukin-2 biosynthetic process [GO:0045086]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of natural killer cell mediated cytotoxicity [GO:0045954]; positive regulation of natural killer cell proliferation [GO:0032819]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone metabolic process [GO:0042448]; regulation of epithelial cell differentiation [GO:0030856]; regulation of multicellular organism growth [GO:0040014]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription by RNA polymerase II [GO:0006357]; response to estradiol [GO:0032355]; response to interleukin-4 [GO:0070670]; succinate metabolic process [GO:0006105]; T cell differentiation in thymus [GO:0033077]; T cell homeostasis [GO:0043029]; taurine metabolic process [GO:0019530]; valine metabolic process [GO:0006573]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P42232}. Nucleus {ECO:0000250|UniProtKB:P42232}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000250}.


uniprotID: Q9NY15
geneSymbol: STAB1
reactome: R-HSA-3000497;
length: 2570
go: ENSG00000010327;
snps: rs12636502 rs9835659 rs2286786 rs7630214 rs4434138 rs13303
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
Stabilin-1 (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1) (FEEL-1) (MS-1 antigen)

sequence:

opentargets:
endocytic vesicle membrane [GO:0030666]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein disulfide oxidoreductase activity [GO:0015035]; scavenger receptor activity [GO:0005044]; cell adhesion [GO:0007155]; cell-cell signaling [GO:0007267]; defense response to bacterium [GO:0042742]; inflammatory response [GO:0006954]; negative regulation of angiogenesis [GO:0016525]; receptor-mediated endocytosis [GO:0006898]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:12077138}; IsoId=Q9NY15-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12077138}; IsoId=Q9NY15-2; Sequence=VSP_050764, VSP_050765; 


uniprotID: Q99469
geneSymbol: STAC
pdb: 2DL4;6B25;
length: 402
go: ENSG00000144681;
snps: rs7634545
name:
SH3 and cysteine-rich domain-containing protein (Src homology 3 and cysteine-rich domain-containing protein)

sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; T-tubule [GO:0030315]; ion channel binding [GO:0044325]; metal ion binding [GO:0046872]; cellular response to heat [GO:0034605]; intracellular signal transduction [GO:0035556]; muscle contraction [GO:0006936]; positive regulation of cation channel activity [GO:2001259]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P97306}. Cell membrane {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P97306}; Peripheral membrane protein {ECO:0000250|UniProtKB:P97306}; Cytoplasmic side {ECO:0000250|UniProtKB:P97306}.


uniprotID: P42224
geneSymbol: STAT1
pdb: 1BF5;1YVL;2KA6;3WWT;
length: 750
go: ENSG00000115415;
reactome:
R-HSA-1059683;R-HSA-1169408;R-HSA-1433557;R-HSA-1839117;R-HSA-186763;R-HSA-6785807;R-HSA-877300;R-HSA-877312;R-HSA-8854691;R-HSA-8939902;R-HSA-8984722;R-HSA-8985947;R-HSA-9013508;R-HSA-9020956;R-HSA-9020958;R-HSA-909733;R-HSA-912694;R-HSA-982772;

name:
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)

sequence:

opentargets:
axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; nuclear chromatin [GO:0000790]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; cadherin binding [GO:0045296]; CCR5 chemokine receptor binding [GO:0031730]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; enzyme binding [GO:0019899]; histone acetyltransferase binding [GO:0035035]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; nuclear hormone receptor binding [GO:0035257]; promoter-specific chromatin binding [GO:1990841]; protein homodimerization activity [GO:0042803]; protein phosphatase 2A binding [GO:0051721]; repressing transcription factor binding [GO:0070491]; RNA polymerase II core promoter sequence-specific DNA binding [GO:0000979]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding [GO:0000983]; transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000982]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin-like protein ligase binding [GO:0044389]; blood circulation [GO:0008015]; cellular response to insulin stimulus [GO:0032869]; cellular response to interferon-beta [GO:0035458]; cellular response to interferon-gamma [GO:0071346]; cellular response to organic cyclic compound [GO:0071407]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; interferon-gamma-mediated signaling pathway [GO:0060333]; interleukin-21-mediated signaling pathway [GO:0038114]; interleukin-27-mediated signaling pathway [GO:0070106]; interleukin-35-mediated signaling pathway [GO:0070757]; interleukin-6-mediated signaling pathway [GO:0070102]; interleukin-9-mediated signaling pathway [GO:0038113]; JAK-STAT cascade [GO:0007259]; macrophage derived foam cell differentiation [GO:0010742]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric mesenchymal cell proliferation involved in metanephros development [GO:0072136]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003340]; negative regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072308]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of apoptotic process [GO:0042981]; regulation of interferon-gamma-mediated signaling pathway [GO:0060334]; regulation of transcription, DNA-templated [GO:0006355]; renal tubule development [GO:0061326]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to hydrogen peroxide [GO:0042542]; response to interferon-beta [GO:0035456]; response to mechanical stimulus [GO:0009612]; response to nutrient [GO:0007584]; response to peptide hormone [GO:0043434]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; type I interferon signaling pathway [GO:0060337]; viral process [GO:0016032]

snps:
rs34255470 rs387906764 rs387906767 rs387906766 rs387906763 rs587777628 rs587776870 rs387906762 rs387906759 rs387906768 rs387906760 rs387906758 rs863223398 rs587777629 rs387906761 rs387906765 rs137852680 rs796065052 rs587777630 rs137852679 rs137852678 rs587777705 rs587777704 rs137852677 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Alpha; Synonyms=p91; IsoId=P42224-1; Sequence=Displayed; Name=Beta; Synonyms=p84; IsoId=P42224-2; Sequence=VSP_006282; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:27796300, ECO:0000269|PubMed:28753426}. Nucleus {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}. Note=Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to IFN-gamma and signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4 (PubMed:15322115). Monomethylation at Lys-525 is required for phosphorylation at Tyr-701 and translocation into the nucleus (PubMed:28753426). Translocates into the nucleus in response to interferon-beta stimulation (PubMed:26479788). {ECO:0000269|PubMed:15322115, ECO:0000269|PubMed:26479788, ECO:0000269|PubMed:28753426}.


uniprotID: Q9Y3F4
geneSymbol: STRAP
reactome: R-HSA-2173788;
length: 350
go: ENSG00000023734;
name:
Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; SMN complex [GO:0032797]; SMN-Sm protein complex [GO:0034719]; RNA binding [GO:0003723]; signaling receptor binding [GO:0005102]; maintenance of gastrointestinal epithelium [GO:0030277]; negative regulation of epithelial cell migration [GO:0010633]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; spliceosomal snRNP assembly [GO:0000387]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3F4-1; Sequence=Displayed; Name=2; IsoId=Q9Y3F4-2; Sequence=VSP_056873; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.


uniprotID: Q9NQZ5
geneSymbol: STARD7
reactome: R-HSA-1483191;
length: 370
go: ENSG00000084090;
snps: rs2276650
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
name:
StAR-related lipid transfer protein 7, mitochondrial (Gestational trophoblastic tumor protein 1) (START domain-containing protein 7) (StARD7)

sequence:

opentargets:
mitochondrial outer membrane [GO:0005741]; lipid binding [GO:0008289]; phosphatidylcholine biosynthetic process [GO:0006656]; phospholipid transport [GO:0015914]


uniprotID: Q13033
geneSymbol: STRN3
pdb: 4N6J;
name: Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)
length: 797
go: ENSG00000196792;
snps: rs2273171
sequence:

opentargets:
cytoplasm [GO:0005737]; dendrite [GO:0030425]; FAR/SIN/STRIPAK complex [GO:0090443]; Golgi apparatus [GO:0005794]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; DNA-binding transcription factor activity [GO:0003700]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; Rho GTPase binding [GO:0017048]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; response to estradiol [GO:0032355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=Beta; IsoId=Q13033-1; Sequence=Displayed; Name=Alpha; IsoId=Q13033-2; Sequence=VSP_006786; 


uniprotID: Q8WVM7
geneSymbol: STAG1
reactome: R-HSA-1221632;R-HSA-2467813;R-HSA-2468052;R-HSA-2470946;R-HSA-2500257;R-HSA-3108214;R-HSA-9018519;
name: Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1)
length: 1258
go: ENSG00000118007;
snps: rs1057519153 rs1376334317 rs34149860
sequence:

opentargets:
chromatin [GO:0000785]; chromosome [GO:0005694]; chromosome, centromeric region [GO:0000775]; cohesin complex [GO:0008278]; cytosol [GO:0005829]; mitotic spindle pole [GO:0097431]; nuclear body [GO:0016604]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; regulation of mitotic spindle assembly [GO:1901673]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WVM7-1; Sequence=Displayed; Name=2; IsoId=Q8WVM7-2; Sequence=VSP_054496; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.


uniprotID: P42226
geneSymbol: STAT6
reactome: R-HSA-186763;R-HSA-3249367;R-HSA-6785807;
pdb: 1OJ5;4Y5U;4Y5W;5D39;5NWM;5NWX;
name: Signal transducer and activator of transcription 6 (IL-4 Stat)
length: 847
go: ENSG00000166888;
snps: rs3024952 rs11172102
sequence:

opentargets:
cytosol [GO:0005829]; membrane raft [GO:0045121]; nuclear chromatin [GO:0000790]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; protein phosphatase binding [GO:0019903]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to reactive nitrogen species [GO:1902170]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-4-mediated signaling pathway [GO:0035771]; mammary gland epithelial cell proliferation [GO:0033598]; mammary gland morphogenesis [GO:0060443]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type 2 immune response [GO:0002829]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of isotype switching to IgE isotypes [GO:0048295]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of type I interferon production [GO:0032481]; regulation of cell proliferation [GO:0042127]; regulation of transcription by RNA polymerase II [GO:0006357]; signal transduction [GO:0007165]; T-helper 1 cell lineage commitment [GO:0002296]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P42226-1; Sequence=Displayed; Name=2; IsoId=P42226-2; Sequence=VSP_031871, VSP_031872; Name=3; IsoId=P42226-3; Sequence=VSP_045282; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.


uniprotID: Q9ULQ0
geneSymbol: STRIP2
name: Striatin-interacting protein 2 (Protein FAM40B)
length: 834
go: ENSG00000128578;
snps: rs2242030
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21834987}. Note=Enriched in lamellipodia.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cell migration [GO:0016477]; cytoskeleton organization [GO:0007010]; regulation of cell shape [GO:0008360]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULQ0-1; Sequence=Displayed; Name=2; IsoId=Q9ULQ0-2; Sequence=VSP_014867, VSP_014868; 


uniprotID: Q9NZ72
geneSymbol: STMN3
name: Stathmin-3 (SCG10-like protein)
length: 180
go: ENSG00000197457;
sequence:
MASTISAYKEKMKELSVLSLICSCFYTQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKSPSDLSPESPMLSSPPKKKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHKALEENNNFSRQAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG

opentargets:
cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; protein domain specific binding [GO:0019904]; tubulin binding [GO:0015631]; blastocyst hatching [GO:0001835]; cytoplasmic microtubule organization [GO:0031122]; microtubule depolymerization [GO:0007019]; negative regulation of Rac protein signal transduction [GO:0035021]; nervous system development [GO:0007399]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of GTPase activity [GO:0043087]; regulation of microtubule polymerization or depolymerization [GO:0031110]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NZ72-1; Sequence=Displayed; Name=2; IsoId=Q9NZ72-2; Sequence=VSP_056525; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:21471001}. Cell projection, growth cone {ECO:0000269|PubMed:21471001}. Cell projection, axon {ECO:0000269|PubMed:21471001}.


uniprotID: Q687X5
geneSymbol: STEAP4
length: 459
go: ENSG00000127954;
snps: rs1981529 rs34741656
name:
Metalloreductase STEAP4 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 4) (SixTransMembrane protein of prostate 2) (Tumor necrosis factor, alpha-induced protein 9)

sequence:

opentargets:
early endosome membrane [GO:0031901]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cupric reductase activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; metal ion binding [GO:0046872]; copper ion import [GO:0015677]; fat cell differentiation [GO:0045444]; ferric iron import across cell outer membrane [GO:0098706]; iron ion homeostasis [GO:0055072]; oxidation-reduction process [GO:0055114]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q687X5-1; Sequence=Displayed; Name=2; IsoId=Q687X5-2; Sequence=VSP_024833; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:18430367}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9H169
geneSymbol: STMN4
pdb: 6BR1;6BRF;6BRY;
name: Stathmin-4 (Stathmin-like protein B3) (RB3)
length: 189
go: ENSG00000015592;
drug: DB01206;
sequence:
MTLAAYKEKMKELPLVSLFCSCFLADPLNKSSYKYEADTVDLNWCVISDMEVIELNKCTSGQSFEVILKPPSFDGVPEFNASLPRRRDPSLEEIQKKLEAAEERRKYQEAELLKHLAEKREHEREVIQKAIEENNNFIKMAKEKLAQKMESNKENREAHLAAMLERLQEKDKHAEEVRKNKELKEEASR

opentargets:
cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; neuron projection [GO:0043005]; tubulin binding [GO:0015631]; microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule polymerization or depolymerization [GO:0031110]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9H169-1; Sequence=Displayed; Name=2; IsoId=Q9H169-2; Sequence=VSP_006279; Name=3; IsoId=Q9H169-3; Sequence=VSP_055279, VSP_055280; Note=No experimental confirmation available.; Name=4; IsoId=Q9H169-4; Sequence=VSP_006279, VSP_055280; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Cell projection, axon {ECO:0000250}.


uniprotID: Q9P289
geneSymbol: STK26
reactome: R-HSA-111465;
pdb: 3GGF;3W8I;4FZA;4FZD;4FZF;4GEH;5XY9;5YF4;
length: 416
go: ENSG00000134602;
snps: rs56035648 rs56044451
name:
Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell periphery [GO:0071944]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; vesicle membrane [GO:0012506]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; magnesium ion binding [GO:0000287]; protein homodimerization activity [GO:0042803]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; cellular response to starvation [GO:0009267]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell migration [GO:0030336]; neuron projection morphogenesis [GO:0048812]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of apoptotic process [GO:0042981]; regulation of hydrogen peroxide-induced cell death [GO:1903205]; response to hydrogen peroxide [GO:0042542]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9P289-1; Sequence=Displayed; Name=2; IsoId=Q9P289-2; Sequence=VSP_041469; Name=3; Synonyms=MST4a; IsoId=Q9P289-3; Sequence=VSP_041470; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17360971, ECO:0000269|PubMed:27807006}. Golgi apparatus {ECO:0000269|PubMed:15037601, ECO:0000269|PubMed:27807006}. Note=Colocalized with RIPOR1 in the Golgi of serum-starved cells and relocated to cytoplasmic punctae, probably vesicular compartments, along with RIPOR1 upon serum stimulation in a Rho- and PDCD10-dependent manner (PubMed:27807006). {ECO:0000269|PubMed:27807006}.


uniprotID: Q9GZT4
geneSymbol: SRR
reactome: R-HSA-977347;
pdb: 3L6B;3L6R;5X2L;
length: 340
go: ENSG00000167720;
drug: DB00133;DB00114;
name:
Serine racemase (EC 5.1.1.18) (D-serine ammonia-lyase) (D-serine dehydratase) (EC 4.3.1.18) (L-serine ammonia-lyase) (L-serine dehydratase) (EC 4.3.1.17)

sequence:

opentargets:
apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; calcium ion binding [GO:0005509]; D-serine ammonia-lyase activity [GO:0008721]; glycine binding [GO:0016594]; L-serine ammonia-lyase activity [GO:0003941]; magnesium ion binding [GO:0000287]; PDZ domain binding [GO:0030165]; protein homodimerization activity [GO:0042803]; pyridoxal phosphate binding [GO:0030170]; serine racemase activity [GO:0030378]; threonine racemase activity [GO:0018114]; aging [GO:0007568]; brain development [GO:0007420]; D-serine biosynthetic process [GO:0070179]; D-serine metabolic process [GO:0070178]; L-serine biosynthetic process [GO:0006564]; L-serine metabolic process [GO:0006563]; protein homotetramerization [GO:0051289]; pyruvate biosynthetic process [GO:0042866]; response to lipopolysaccharide [GO:0032496]; response to morphine [GO:0043278]; serine family amino acid metabolic process [GO:0009069]


uniprotID: Q8WWF3
geneSymbol: SSMEM1
name: Serine-rich single-pass membrane protein 1
length: 244
go: ENSG00000165120;
opentargets: integral component of membrane [GO:0016021]
snps: rs4728190
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9UHV2
geneSymbol: SERTAD1
length: 236
go: ENSG00000197019;
snps: rs268687
name:
SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (p34(SEI-1)) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]


uniprotID: Q9NRC1
geneSymbol: ST7
name: Suppressor of tumorigenicity 7 protein (Protein FAM4A1) (Protein HELG)
length: 585
go: ENSG00000004866;
snps: rs201219065 rs1362000016
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; extracellular matrix organization [GO:0030198]; regulation of cell differentiation [GO:0045595]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q9NRC1-1; Sequence=Displayed; Name=2; IsoId=Q9NRC1-2; Sequence=VSP_034113, VSP_034117; Name=3; IsoId=Q9NRC1-3; Sequence=VSP_034112, VSP_034113, VSP_034117; Name=4; IsoId=Q9NRC1-4; Sequence=VSP_034109, VSP_034110, VSP_034117; Name=5; IsoId=Q9NRC1-5; Sequence=VSP_034109, VSP_034110, VSP_034113, VSP_034117; Name=6; IsoId=Q9NRC1-6; Sequence=VSP_034108, VSP_034111, VSP_034113, VSP_034116, VSP_034117; Name=7; IsoId=Q9NRC1-7; Sequence=VSP_034113, VSP_034114, VSP_034115; 


uniprotID: Q8IZP2
geneSymbol: ST13P4
name: Putative protein FAM10A4 (Suppression of tumorigenicity 13 pseudogene 4)
length: 240
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; protein dimerization activity [GO:0046983]; chaperone cofactor-dependent protein refolding [GO:0051085]


uniprotID: O95630
geneSymbol: STAMBP
reactome: R-HSA-5689901;
pdb: 2XZE;3RZU;3RZV;5IXF;
length: 424
go: ENSG00000124356;
snps: rs143739249 rs397509387 rs781694797 rs397514697 rs202100019
location: SUBCELLULAR LOCATION: Nucleus. Membrane; Peripheral membrane protein. Cytoplasm. Early endosome.
name:
STAM-binding protein (EC 3.4.19.-) (Associated molecule with the SH3 domain of STAM) (Endosome-associated ubiquitin isopeptidase)

sequence:

opentargets:
cleavage furrow [GO:0032154]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Lys63-specific deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; protein domain specific binding [GO:0019904]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; JAK-STAT cascade [GO:0007259]; mitotic cytokinesis [GO:0000281]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of cell proliferation [GO:0008284]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95630-1; Sequence=Displayed; Name=2; IsoId=O95630-2; Sequence=VSP_057197; 


uniprotID: Q8NFT2
geneSymbol: STEAP2
reactome: R-HSA-917977;
length: 490
go: ENSG00000157214;
snps: rs194520 rs17863046 rs13228098 rs194524 rs194525
name:
Metalloreductase STEAP2 (EC 1.16.1.-) (Prostate cancer-associated protein 1) (Protein up-regulated in metastatic prostate cancer) (PUMPCn) (Six-transmembrane epithelial antigen of prostate 2) (SixTransMembrane protein of prostate 1)

sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; integral component of Golgi membrane [GO:0030173]; plasma membrane [GO:0005886]; trans-Golgi network transport vesicle [GO:0030140]; cupric reductase activity [GO:0008823]; ferric-chelate reductase (NADPH) activity [GO:0052851]; metal ion binding [GO:0046872]; transporter activity [GO:0005215]; copper ion import [GO:0015677]; endocytosis [GO:0006897]; ferric iron import across cell outer membrane [GO:0098706]; Golgi to plasma membrane transport [GO:0006893]; iron ion homeostasis [GO:0055072]; oxidation-reduction process [GO:0055114]; regulated exocytosis [GO:0045055]; response to hormone [GO:0009725]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NFT2-1; Sequence=Displayed; Name=2; IsoId=Q8NFT2-2; Sequence=VSP_030999; Name=3; IsoId=Q8NFT2-3; Sequence=VSP_045590; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:12429817}; Multi-pass membrane protein {ECO:0000269|PubMed:12429817}.


uniprotID: P09430
geneSymbol: TNP1
name: Spermatid nuclear transition protein 1 (STP-1) (TP-1)
sequence: MSTSRKLKSHGMRRSKSRSPHKGVKRGGSKRKYRKGNLKSRKRGDDANRNYRSHL
length: 55
go: ENSG00000118245;
opentargets:
male germ cell nucleus [GO:0001673]; nuclear nucleosome [GO:0000788]; nucleosome [GO:0000786]; nucleus [GO:0005634]; DNA binding [GO:0003677]; chromatin remodeling [GO:0006338]; chromatin silencing [GO:0006342]; fertilization, exchange of chromosomal proteins [GO:0035042]; flagellated sperm motility [GO:0030317]; multicellular organism development [GO:0007275]; negative regulation of transcription, DNA-templated [GO:0045892]; nucleosome disassembly [GO:0006337]; positive regulation of protein processing [GO:0010954]; sexual reproduction [GO:0019953]; single strand break repair [GO:0000012]; spermatid development [GO:0007286]; spermatid nucleus differentiation [GO:0007289]; spermatid nucleus elongation [GO:0007290]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10856}. Chromosome {ECO:0000250|UniProtKB:P10856}. Note=Loaded onto the nucleosomes of condensing spermatids. {ECO:0000250|UniProtKB:P10856}.


uniprotID: Q6NZ63
geneSymbol: STEAP1B
name: STEAP family member 1B
length: 245
go: ENSG00000105889;
opentargets: endosome [GO:0005768]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]
snps: rs7787814 rs16881810 rs16881812 rs16881817
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NZ63-1; Sequence=Displayed; Name=2; IsoId=Q6NZ63-2; Sequence=VSP_054116, VSP_054117; Note=No experimental confirmation available.; 


uniprotID: Q9NRP7
geneSymbol: STK36
name: Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)
length: 1315
go: ENSG00000163482;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; transcription factor binding [GO:0008134]; brain development [GO:0007420]; cilium assembly [GO:0060271]; epithelial cilium movement [GO:0003351]; positive regulation of hh target transcription factor activity [GO:0007228]; positive regulation of smoothened signaling pathway [GO:0045880]; post-embryonic development [GO:0009791]; protein phosphorylation [GO:0006468]; regulation of DNA-binding transcription factor activity [GO:0051090]

snps:
rs55706732 rs35038757 rs1863703 rs34027859 rs45586733 rs17856747 rs34128793 rs16859180 rs1344642 rs6709303 rs1244829273 rs35448374 rs17856748 rs34271431 rs13023540 rs36099639 rs1863704 rs55633575 rs56278660 rs12993599 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334}; IsoId=Q9NRP7-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:10574462}; IsoId=Q9NRP7-2; Sequence=VSP_051983; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10806483}. Nucleus {ECO:0000269|PubMed:10806483}. Note=Low levels also present in the nucleus. {ECO:0000269|PubMed:10806483}.


uniprotID: Q9UL54
geneSymbol: TAOK2
length: 1235
go: ENSG00000149930;
drug: DB04522;
name:
Serine/threonine-protein kinase TAO2 (EC 2.7.11.1) (Kinase from chicken homolog C) (hKFC-C) (Prostate-derived sterile 20-like kinase 1) (PSK-1) (PSK1) (Prostate-derived STE20-like kinase 1) (Thousand and one amino acid protein kinase 2)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; axon [GO:0030424]; axonal growth cone [GO:0044295]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; dendritic growth cone [GO:0044294]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; mitogen-activated protein kinase kinase binding [GO:0031434]; neuropilin binding [GO:0038191]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; activation of protein kinase activity [GO:0032147]; apoptotic process [GO:0006915]; axonogenesis [GO:0007409]; basal dendrite arborization [GO:0150020]; basal dendrite morphogenesis [GO:0150019]; cell migration [GO:0016477]; cellular response to DNA damage stimulus [GO:0006974]; focal adhesion assembly [GO:0048041]; mitotic G2 DNA damage checkpoint [GO:0007095]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein targeting to membrane [GO:0006612]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cell growth [GO:0001558]; regulation of cell shape [GO:0008360]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated MAPK cascade [GO:0051403]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PSK1-alpha, TAO2; IsoId=Q9UL54-1; Sequence=Displayed; Name=2; Synonyms=PSK1-beta; IsoId=Q9UL54-2; Sequence=VSP_015969, VSP_015970; Name=3; IsoId=Q9UL54-3; Sequence=VSP_015967, VSP_015968; Note=No experimental confirmation available.; Name=4; IsoId=Q9UL54-4; Sequence=VSP_044894; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.; SUBCELLULAR LOCATION: Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8. {ECO:0000250}.


uniprotID: Q9H2K8
geneSymbol: TAOK3
length: 898
go: ENSG00000135090;
snps: rs428073 rs55857273
name:
Serine/threonine-protein kinase TAO3 (EC 2.7.11.1) (Cutaneous T-cell lymphoma-associated antigen HD-CL-09) (CTCL-associated antigen HD-CL-09) (Dendritic cell-derived protein kinase) (JNK/SAPK-inhibitory kinase) (Jun kinase-inhibitory kinase) (Kinase from chicken homolog A) (hKFC-A) (Thousand and one amino acid protein 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase inhibitor activity [GO:0004860]; protein serine/threonine kinase activity [GO:0004674]; transferase activity [GO:0016740]; activation of MAPKK activity [GO:0000186]; activation of protein kinase activity [GO:0032147]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; MAPK cascade [GO:0000165]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of JNK cascade [GO:0046329]; positive regulation of JNK cascade [GO:0046330]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:13679851}. Cell membrane {ECO:0000269|PubMed:13679851}; Peripheral membrane protein {ECO:0000269|PubMed:13679851}. Note=Also localized to the peripheral cell membrane.


uniprotID: Q16623
geneSymbol: STX1A
name: Syntaxin-1A (Neuron-specific antigen HPC-1)
length: 288
go: ENSG00000106089;
reactome:
R-HSA-181429;R-HSA-181430;R-HSA-210500;R-HSA-212676;R-HSA-264642;R-HSA-264876;R-HSA-422356;R-HSA-449836;R-HSA-5250971;R-HSA-5682910;R-HSA-6794361;R-HSA-888590;

sequence:

opentargets:
actomyosin [GO:0042641]; axon [GO:0030424]; cell junction [GO:0030054]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; extracellular region [GO:0005576]; glutamatergic synapse [GO:0098978]; integral component of membrane [GO:0016021]; integral component of presynaptic membrane [GO:0099056]; integral component of synaptic vesicle membrane [GO:0030285]; neuron projection [GO:0043005]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; synaptobrevin 2-SNAP-25-syntaxin-1a complex [GO:0070044]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [GO:0070032]; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [GO:0070033]; voltage-gated potassium channel complex [GO:0008076]; ATP-dependent protein binding [GO:0043008]; calcium channel inhibitor activity [GO:0019855]; calcium-dependent protein binding [GO:0048306]; chloride channel inhibitor activity [GO:0019869]; ion channel binding [GO:0044325]; kinase binding [GO:0019900]; myosin head/neck binding [GO:0032028]; protein binding, bridging [GO:0030674]; protein domain specific binding [GO:0019904]; protein heterodimerization activity [GO:0046982]; protein N-terminus binding [GO:0047485]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; cytokine-mediated signaling pathway [GO:0019221]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of catecholamine secretion [GO:0033605]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of norepinephrine secretion [GO:0010701]; protein localization to membrane [GO:0072657]; regulation of insulin secretion [GO:0050796]; regulation of synaptic vesicle priming [GO:0010807]; response to gravity [GO:0009629]; secretion by cell [GO:0032940]; SNARE complex assembly [GO:0035493]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q16623-1; Sequence=Displayed; Name=2; Synonyms=1C; IsoId=Q16623-2; Sequence=VSP_006338; Note=Expression is up-regulated by phorbol 12-myristate 13-acetate (PMA), but not by forskolin.; Name=3; IsoId=Q16623-3; Sequence=VSP_006339; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35526}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:O35526}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:O35526}. Cell membrane {ECO:0000250|UniProtKB:P32851}. Note=Colocalizes with KCNB1 at the cell membrane. {ECO:0000250|UniProtKB:P32851}.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.


uniprotID: Q9P031
geneSymbol: CCDC59
reactome: R-HSA-5683826;R-HSA-5688031;
length: 241
go: ENSG00000133773;
opentargets: nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; cellular protein metabolic process [GO:0044267]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59) (TTF-1-associated protein BR2)

sequence:


uniprotID: P78539
geneSymbol: SRPX
name: Sushi repeat-containing protein SRPX
length: 464
go: ENSG00000101955;
snps: rs1123773 rs35318931
location: SUBCELLULAR LOCATION: Cell surface {ECO:0000305}. Note=Possibly surface of photoreceptor cell.
sequence:

opentargets:
autophagosome [GO:0005776]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; autophagy [GO:0006914]; cell adhesion [GO:0007155]; negative regulation of cell proliferation involved in contact inhibition [GO:0060244]; phagolysosome assembly [GO:0001845]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; response to endoplasmic reticulum stress [GO:0034976]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=P78539-1; Sequence=Displayed; Name=2; IsoId=P78539-2; Sequence=VSP_004430; Name=3; IsoId=P78539-3; Sequence=VSP_043056; Note=No experimental confirmation available.; Name=4; IsoId=P78539-4; Sequence=VSP_045468; Note=No experimental confirmation available.; Name=5; IsoId=P78539-5; Sequence=VSP_046757; 


uniprotID: P30872
geneSymbol: SSTR1
reactome: R-HSA-375276;R-HSA-418594;
name: Somatostatin receptor type 1 (SS-1-R) (SS1-R) (SS1R) (SRIF-2)
length: 391
go: ENSG00000139874;
drug: DB00104;DB06663;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]; cellular response to estradiol stimulus [GO:0071392]; cellular response to leukemia inhibitory factor [GO:1990830]; cerebellum development [GO:0021549]; forebrain development [GO:0030900]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glutamate receptor signaling pathway [GO:0007215]; negative regulation of cell proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; response to starvation [GO:0042594]; spermatogenesis [GO:0007283]


uniprotID: Q08945
geneSymbol: SSRP1
pdb: 4IFS;5UMR;5UMS;5VWE;
length: 709
go: ENSG00000149136;
snps: rs768436 rs11540304
reactome:
R-HSA-112382;R-HSA-167152;R-HSA-167200;R-HSA-167238;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-674695;R-HSA-6796648;R-HSA-6804756;R-HSA-75955;

name:
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)

sequence:

opentargets:
chromosome [GO:0005694]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; regulation of signal transduction by p53 class mediator [GO:1901796]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10421373, ECO:0000269|PubMed:22002106}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Chromosome {ECO:0000269|PubMed:10421373}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. {ECO:0000250|UniProtKB:Q05344}.


uniprotID: Q8IYB3
geneSymbol: SRRM1
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;
pdb: 1MP1;6FF4;
length: 904
go: ENSG00000133226;
snps: rs17857102
name:
Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA splicing, via spliceosome [GO:0000398]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]; RNA splicing, via transesterification reactions [GO:0000375]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IYB3-1; Sequence=Displayed; Name=2; IsoId=Q8IYB3-2; Sequence=VSP_016522, VSP_016523; 

location:
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:12624182, ECO:0000269|PubMed:9531537}. Nucleus speckle {ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:9531537}.


uniprotID: Q9Y5M8
geneSymbol: SRPRB
reactome: R-HSA-1799339;R-HSA-381038;
name: Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)
length: 271
go: ENSG00000144867;
snps: rs1107413
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic microtubule [GO:0005881]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; GTP binding [GO:0005525]; IRE1-mediated unfolded protein response [GO:0036498]


uniprotID: O43805
geneSymbol: SSNA1
reactome: R-HSA-2565942;R-HSA-380259;R-HSA-380270;R-HSA-380284;R-HSA-380320;R-HSA-5620912;R-HSA-8854518;
name: Sjoegren syndrome nuclear autoantigen 1 (Nuclear autoantigen of 14 kDa)
length: 119
go: ENSG00000176101;
snps: rs1289962028
sequence:
MTQQGAALQNYNNELVKCIEELCQKREELCRQIQEEEDEKQRLQNEVRQLTEKLARVNENLARKIASRNEFDRTIAETEAAYLKILESSQTLLSVLKREAGNLTKATAPDQKSSGGRDS

opentargets:
centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; ciliary basal body-plasma membrane docking [GO:0097711]; ciliary receptor clustering involved in smoothened signaling pathway [GO:0060830]; G2/M transition of mitotic cell cycle [GO:0000086]; intraciliary transport [GO:0042073]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}.


uniprotID: O94768
geneSymbol: STK17B
pdb: 3LM0;3LM5;
length: 372
go: ENSG00000081320;
drug: DB04216;
snps: rs34740616
name:
Serine/threonine-protein kinase 17B (EC 2.7.11.1) (DAP kinase-related apoptosis-inducing protein kinase 2)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; intracellular signal transduction [GO:0035556]; positive regulation of fibroblast apoptotic process [GO:2000271]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9786912}. Cell membrane {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Colocalizes with STK17B at the plasma membrane. {ECO:0000250}.


uniprotID: O60225
geneSymbol: SSX5
name: Protein SSX5
length: 188
go: ENSG00000165583;
snps: rs4824675
sequence:
MNGDDAFVRRPRVGSQIPEKMQKAFDDIAKYFSEKEWEKMKASEKIIYVYMKRKYEAMTKLGFKATLPPFMRNKRVADFQGNDFDNDPNRGNQVEHPQMTFGRLQGIFPKITPEKPAEEGNDSKGVPEASGPQNNGKQLRPSGKLNTSEKVNKTSGPKRGKHAWTHRVRERKQLVIYEEISDPQEDDE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60225-1; Sequence=Displayed; Name=2; IsoId=O60225-2; Sequence=VSP_006274; Note=No experimental confirmation available.; 


uniprotID: Q7RTT6
geneSymbol: SSX6
name: Putative protein SSX6
length: 188
snps: rs5952474 rs17327911
sequence:
MNGDDAFAKRPRDDAKASEKRSKAFDDIAKYFSKEEWEKMKFSEKISCVHMKRKYEAMTKLGFNVTLSLFMRNKRATDSQRNDSDNDRNRGNEVERPQMTFGRLQRIIPKIMPEKPAEEGSDSKGVPEASGPQNDGKKLCPPGKASSSEKIHERSGPKRGKHAWTHRLRERKQLVIYEEISDPEEDDK


uniprotID: Q7RTT5
geneSymbol: SSX7
name: Protein SSX7
length: 188
go: ENSG00000187754;
snps: rs3122210
sequence:
MNGDDAFARRPRAGAQIPEKIQKSFDDIAKYFSKKEWEKMKSLEKISYVYMKRKYEAMTKLGFKATLPPFMHNTGATDLQGNDFDNDRNQGNQVERPQMTFCRLQRIFPKIMPKKPAEEGNDSKGVPEASGSQNDGKHLCPPGKPSTSEKINKTSGPKRGKHAWTHRLRERKQLVIYEEISDPEEDDE


uniprotID: P0CL85
geneSymbol: STAG3L3
name: STAG3-like protein 3 (Stromal antigen 3-like protein 3)
length: 134
opentargets: nucleus [GO:0005634]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
sequence:
MIFSMLRKLPKVTCRDVLPEIRAICIEEIGCWMQSYSTSFLTDSYLKYIGWTLHDKHREVRVKCVKALKGLYGNRDLTARLELFTGCFKDWMVSMIMDREYSVAVEAVRLLILILKNMEGVLMDVDCESVYPIV

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P0CL85-1; Sequence=Displayed; Name=2; IsoId=P0CL85-2; Sequence=VSP_041016; 


uniprotID: Q8TBR4
geneSymbol: STAG3L4
name: Putative STAG3-like protein 4 (Stromal antigen 3-like protein 4)
length: 150
snps: rs1045513
sequence:
MSGWIATSKTRMQDFWSLLTFSSDLVDVKDSGDYPLTAPGLSWKKFQGSFCEFVGTLVCRCQYILLHDDFPMDNLISLLTGFSDSQVCAFCHTSTLAAMKLMTSLVRVALQLSLHEDINQRQYEAERNKGPGQRAPERLESLLEKHKELH


uniprotID: P0DMN0
geneSymbol: SULT1A4
reactome: R-HSA-156584;
length: 295
go: ENSG00000261052;
snps: rs1460887051 rs751527244
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Sulfotransferase 1A4 (ST1A4) (EC 2.8.2.1) (Aryl sulfotransferase 1A3/1A4) (Sulfotransferase 1A3/1A4)

sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; catecholamine metabolic process [GO:0006584]; steroid metabolic process [GO:0008202]


uniprotID: Q96FJ0
geneSymbol: STAMBPL1
reactome: R-HSA-5689901;
pdb: 2ZNR;2ZNV;
name: AMSH-like protease (AMSH-LP) (EC 3.4.19.-) (STAM-binding protein-like 1)
length: 436
go: ENSG00000138134;
snps: rs12254856 rs34270879 rs9988723
sequence:

opentargets:
cytosol [GO:0005829]; endosome [GO:0005768]; membrane [GO:0016020]; Lys63-specific deubiquitinase activity [GO:0061578]; metal ion binding [GO:0046872]; metallopeptidase activity [GO:0008237]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96FJ0-1; Sequence=Displayed; Name=2; IsoId=Q96FJ0-2; Sequence=VSP_014648; 


uniprotID: Q96MF2
geneSymbol: STAC3
pdb: 2DB6;6B29;
name: SH3 and cysteine-rich domain-containing protein 3
length: 364
go: ENSG00000185482;
snps: rs140291094
sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nucleoplasm [GO:0005654]; sarcolemma [GO:0042383]; voltage-gated calcium channel complex [GO:0005891]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; intracellular signal transduction [GO:0035556]; neuromuscular synaptic transmission [GO:0007274]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]; skeletal muscle contraction [GO:0003009]; skeletal muscle fiber development [GO:0048741]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96MF2-1; Sequence=Displayed; Name=2; IsoId=Q96MF2-2; Sequence=VSP_017914; Name=3; IsoId=Q96MF2-3; Sequence=VSP_055272; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BZ71}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8BZ71}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BZ71}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BZ71}. Note=Co-localizes with CACNA1S and CACNA1C on T-tubules (extensions of the sarcolemma). {ECO:0000250|UniProtKB:Q8BZ71}.


uniprotID: Q9BX79
geneSymbol: STRA6
reactome: R-HSA-2453864;R-HSA-2453902;
length: 667
go: ENSG00000137868;
name:
Receptor for retinol uptake STRA6 (Retinol-binding protein receptor STRA6) (Stimulated by retinoic acid gene 6 protein homolog)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; retinal binding [GO:0016918]; retinol binding [GO:0019841]; retinol transmembrane transporter activity [GO:0034632]; signaling receptor activity [GO:0038023]; adrenal gland development [GO:0030325]; alveolar primary septum development [GO:0061143]; artery morphogenesis [GO:0048844]; blood vessel development [GO:0001568]; camera-type eye development [GO:0043010]; cognition [GO:0050890]; developmental growth [GO:0048589]; diaphragm development [GO:0060539]; digestive tract morphogenesis [GO:0048546]; ductus arteriosus closure [GO:0097070]; ear development [GO:0043583]; embryonic camera-type eye formation [GO:0060900]; embryonic digestive tract development [GO:0048566]; eyelid development in camera-type eye [GO:0061029]; face morphogenesis [GO:0060325]; feeding behavior [GO:0007631]; female genitalia development [GO:0030540]; head development [GO:0060322]; head morphogenesis [GO:0060323]; heart development [GO:0007507]; kidney development [GO:0001822]; learning [GO:0007612]; lung alveolus development [GO:0048286]; lung development [GO:0030324]; lung vasculature development [GO:0060426]; neuromuscular process [GO:0050905]; nose morphogenesis [GO:0043585]; paramesonephric duct development [GO:0061205]; positive regulation of behavior [GO:0048520]; pulmonary artery morphogenesis [GO:0061156]; pulmonary valve morphogenesis [GO:0003184]; retinoid metabolic process [GO:0001523]; retinol transport [GO:0034633]; smooth muscle tissue development [GO:0048745]; uterus morphogenesis [GO:0061038]; ventricular septum development [GO:0003281]; vitamin A import [GO:0071939]; vocal learning [GO:0042297]

snps:
rs118203961 rs909629751 rs118203958 rs151341424 rs118203962 rs17852249 rs869025269 rs11545567 rs736118 rs144691445 rs118203960 rs118203959 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q9BX79-1; Sequence=Displayed; Name=2; IsoId=Q9BX79-2; Sequence=VSP_029439; Note=No experimental confirmation available.; Name=3; IsoId=Q9BX79-3; Sequence=VSP_029438; Name=4; IsoId=Q9BX79-4; Sequence=VSP_029437; Note=No experimental confirmation available.; Name=5; IsoId=Q9BX79-5; Sequence=VSP_046776; Name=6; IsoId=Q9BX79-6; Sequence=VSP_047497; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18316031, ECO:0000269|PubMed:21901792, ECO:0000269|PubMed:9452451}; Multi-pass membrane protein {ECO:0000305}. Note=In the retinal pigment epithelium localizes to the basolateral membrane. {ECO:0000250|UniProtKB:Q0V8E7}.


uniprotID: P61266
geneSymbol: STX1B
reactome: R-HSA-5250971;R-HSA-5682910;
name: Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)
length: 288
go: ENSG00000099365;
snps: rs724159974 rs727502806
sequence:

opentargets:
axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; neuromuscular junction [GO:0031594]; nuclear lamina [GO:0005652]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; SNARE complex [GO:0031201]; spindle [GO:0005819]; synaptic vesicle [GO:0008021]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; signaling receptor binding [GO:0005102]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; exocytic insertion of neurotransmitter receptor to postsynaptic membrane [GO:0098967]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; negative regulation of macropinocytosis [GO:1905302]; negative regulation of neuron projection development [GO:0010977]; negative regulation of synaptic vesicle recycling [GO:1903422]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of neurotransmitter secretion [GO:0001956]; positive regulation of spontaneous neurotransmitter secretion [GO:1904050]; regulation of gene expression [GO:0010468]; regulation of synaptic activity [GO:0060025]; regulation of synaptic vesicle priming [GO:0010807]; spontaneous neurotransmitter secretion [GO:0061669]; synaptic vesicle docking [GO:0016081]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion [GO:0006906]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61266-1; Sequence=Displayed; Name=2; Synonyms=STX1B-DeltaTMD; IsoId=P61266-2; Sequence=VSP_047681; Note=The glycine-rich C-terminus serves as an unconventional nuclear localization signal.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:18691641}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18691641}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18691641}. Note=Colocalizes with Lamin A/C and NuMA in interphasic nuclei, and with NuMA and gamma-tubulin in the pericentrosomal region of the mitotic spindle in dividing cells.


uniprotID: Q8N801
geneSymbol: STPG4
length: 248
go: ENSG00000239605;
snps: rs815804 rs17036300
name:
Protein STPG4 (Gonad-specific expression gene protein) (GSE) (Sperm-tail PG-rich repeat-containing protein 4)

sequence:

opentargets:
cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; germinal vesicle [GO:0042585]; male pronucleus [GO:0001940]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; C-5 methylation of cytosine [GO:0090116]; chromatin organization [GO:0006325]; DNA demethylation of male pronucleus [GO:0044727]; positive regulation of DNA demethylation [GO:1901537]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N801-1; Sequence=Displayed; Name=2; IsoId=Q8N801-2; Sequence=VSP_047926; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAG5}. Nucleus {ECO:0000250|UniProtKB:Q9DAG5}. Note=Localizes in female and male zygote pronucleus. Associates preferentially with the paternal chromatin during zygote development. {ECO:0000250|UniProtKB:Q9DAG5}.


uniprotID: Q9UGK3
geneSymbol: STAP2
reactome: R-HSA-8849474;
pdb: 2EL8;
name: Signal-transducing adaptor protein 2 (STAP-2) (Breast tumor kinase substrate) (BRK substrate)
length: 403
go: ENSG00000178078;
snps: rs7247504
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10980601}.
sequence:

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; signaling adaptor activity [GO:0035591]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UGK3-1; Sequence=Displayed; Name=2; IsoId=Q9UGK3-2; Sequence=VSP_041403; Note=Alu insert from position 358 to 403.; 


uniprotID: P59095
geneSymbol: STARD6
reactome: R-HSA-196108;
pdb: 2MOU;
name: StAR-related lipid transfer protein 6 (START domain-containing protein 6) (StARD6)
length: 220
go: ENSG00000174448;
opentargets: lipid binding [GO:0008289]; lipid transport [GO:0006869]
snps: rs2917782
sequence:


uniprotID: P27105
geneSymbol: STOM
reactome: R-HSA-2672351;R-HSA-6798695;
name: Erythrocyte band 7 integral membrane protein (Protein 7.2b) (Stomatin)
length: 288
go: ENSG00000148175;
sequence:

opentargets:
azurophil granule membrane [GO:0035577]; blood microparticle [GO:0072562]; cytoskeleton [GO:0005856]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrion [GO:0005739]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; vesicle [GO:0031982]; protein homodimerization activity [GO:0042803]; RNA polymerase binding [GO:0070063]; neutrophil degranulation [GO:0043312]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation of protein targeting to membrane [GO:0090314]; protein homooligomerization [GO:0051260]; regulation of acid-sensing ion channel activity [GO:1901585]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P27105-1; Sequence=Displayed; Name=2; IsoId=P27105-2; Sequence=VSP_044669; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9243190}; Peripheral membrane protein {ECO:0000269|PubMed:9243190}; Cytoplasmic side {ECO:0000269|PubMed:9243190}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9243190}. Cell membrane {ECO:0000269|PubMed:12130500}; Lipid-anchor {ECO:0000269|PubMed:12130500}; Cytoplasmic side {ECO:0000269|PubMed:12130500}. Membrane raft {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:23219802}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P54116}. Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190). Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190). Associates with alpha-granular lipid rafts (PubMed:12130500). Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:9243190}.


uniprotID: P49842
geneSymbol: STK19
name: Serine/threonine-protein kinase 19 (EC 2.7.11.1) (Protein G11) (Protein RP1)
length: 368
go: ENSG00000204344;
snps: rs34843142 rs267600971 rs616634 rs7743647
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nuclear speck [GO:0016607]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; protein phosphorylation [GO:0006468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=G11-Z; IsoId=P49842-1; Sequence=Displayed; Name=2; Synonyms=G11-Z-short; IsoId=P49842-2; Sequence=VSP_004433; Name=3; Synonyms=G11-Y; IsoId=P49842-3; Sequence=VSP_004432; Name=4; Synonyms=G11-Y-short; IsoId=P49842-4; Sequence=VSP_004432, VSP_004433; 


uniprotID: Q9P2F5
geneSymbol: STOX2
name: Storkhead-box protein 2
length: 926
go: ENSG00000173320;
sequence:

opentargets:
embryo development ending in birth or egg hatching [GO:0009792]; maternal placenta development [GO:0001893]; response to bacterium [GO:0009617]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P2F5-1; Sequence=Displayed; Name=2; IsoId=Q9P2F5-2; Sequence=VSP_030072, VSP_030073; 


uniprotID: Q9BXU1
geneSymbol: STK31
length: 1019
go: ENSG00000196335;
name:
Serine/threonine-protein kinase 31 (EC 2.7.11.1) (Serine/threonine-protein kinase NYD-SPK) (Sugen kinase 396) (SgK396)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; nuclease activity [GO:0004518]; protein serine/threonine kinase activity [GO:0004674]; RNA catabolic process [GO:0006401]

snps:
rs6945306 rs56268851 rs10264952 rs10264967 rs55950645 rs35545265 rs35995607 rs56244148 rs4722266 rs34414354 rs55796076 rs10263079 rs10247878 rs41273999 rs56181834 rs55794023 rs33998018 rs56391043 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BXU1-1; Sequence=Displayed; Name=2; IsoId=Q9BXU1-2; Sequence=VSP_024389; Note=No experimental confirmation available.; Name=3; IsoId=Q9BXU1-3; Sequence=VSP_045210; 


uniprotID: O15400
geneSymbol: STX7
name: Syntaxin-7
length: 261
go: ENSG00000079950;
sequence:

opentargets:
azurophil granule [GO:0042582]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle [GO:0030139]; endomembrane system [GO:0012505]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; immunological synapse [GO:0001772]; integral component of membrane [GO:0016021]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; tertiary granule [GO:0070820]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; intracellular protein transport [GO:0006886]; organelle assembly [GO:0070925]; organelle localization [GO:0051640]; positive regulation of receptor localization to synapse [GO:1902685]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15400-1; Sequence=Displayed; Name=2; IsoId=O15400-2; Sequence=VSP_012938; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.


uniprotID: P32856
geneSymbol: STX2
name: Syntaxin-2 (Epimorphin)
length: 288
go: ENSG00000111450;
snps: rs17564 rs7301926
location: SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; endomembrane system [GO:0012505]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; calcium-dependent protein binding [GO:0048306]; protein dimerization activity [GO:0046983]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; acrosome reaction [GO:0007340]; animal organ morphogenesis [GO:0009887]; cell differentiation [GO:0030154]; cornified envelope assembly [GO:1903575]; ectoderm development [GO:0007398]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; protein complex oligomerization [GO:0051259]; response to hydroperoxide [GO:0033194]; signal transduction [GO:0007165]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=3; IsoId=P32856-1; Sequence=Displayed; Name=1; IsoId=P32856-2; Sequence=VSP_006334; Name=2; IsoId=P32856-3; Sequence=VSP_006335; 


uniprotID: Q5VWQ0
geneSymbol: RSBN1
name: Lysine-specific demethylase 9 (KDM9) (EC 1.14.11.-) (Round spermatid basic protein 1)
length: 802
go: ENSG00000081019;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]; chromatin organization [GO:0006325]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5VWQ0-1; Sequence=Displayed; Name=4; IsoId=Q5VWQ0-4; Sequence=VSP_027656; 


uniprotID: Q9BXY4
geneSymbol: RSPO3
reactome: R-HSA-4641263;R-HSA-8939256;
length: 272
go: ENSG00000146374;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2TJ95}.
name:
R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; heparin binding [GO:0008201]; signaling receptor binding [GO:0005102]; blood vessel remodeling [GO:0001974]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of Wnt signaling pathway [GO:0030177]; positive regulation of Wnt signaling pathway, planar cell polarity pathway [GO:2000096]; regulation of Wnt signaling pathway [GO:0030111]; sprouting angiogenesis [GO:0002040]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BXY4-1; Sequence=Displayed; Name=2; IsoId=Q9BXY4-2; Sequence=VSP_018324; Note=No experimental confirmation available.; 


uniprotID: Q96DX4
geneSymbol: RSPRY1
name: RING finger and SPRY domain-containing protein 1
length: 576
go: ENSG00000159579;
opentargets: extracellular region [GO:0005576]; metal ion binding [GO:0046872]
snps: rs864309652
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96DX4-1; Sequence=Displayed; Name=2; IsoId=Q96DX4-2; Sequence=VSP_023382, VSP_023383; 


uniprotID: Q96IZ7
geneSymbol: RSRC1
name: Serine/Arginine-related protein 53 (SRrp53) (Arginine/serine-rich coiled-coil protein 1)
length: 334
go: ENSG00000174891;
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; alternative mRNA splicing, via spliceosome [GO:0000380]; mRNA splicing, via spliceosome [GO:0000398]; nucleocytoplasmic transport [GO:0006913]; protein phosphorylation [GO:0006468]; response to antibiotic [GO:0046677]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96IZ7-1; Sequence=Displayed; Name=2; IsoId=Q96IZ7-2; Sequence=VSP_013120; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm. {ECO:0000250}.


uniprotID: Q9BUV0
geneSymbol: RSRP1
name: Arginine/serine-rich protein 1
length: 290
go: ENSG00000117616;
snps: rs34619962 rs1043879
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BUV0-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9BUV0-2; Sequence=VSP_027305; Name=3; IsoId=Q9BUV0-3; Sequence=VSP_027306, VSP_027307; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q8WYR4
geneSymbol: RSPH1
length: 309
go: ENSG00000160188;
snps: rs587777060
name:
Radial spoke head 1 homolog (Cancer/testis antigen 79) (CT79) (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein)

sequence:

opentargets:
condensed nuclear chromosome [GO:0000794]; cytosol [GO:0005829]; meiotic spindle [GO:0072687]; motile cilium [GO:0031514]; nucleus [GO:0005634]; outer dense fiber [GO:0001520]; axoneme assembly [GO:0035082]; meiotic cell cycle [GO:0051321]; spermatid development [GO:0007286]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WYR4-1; Sequence=Displayed; Name=2; IsoId=Q8WYR4-2; Sequence=VSP_055743; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000269|PubMed:23993197}. Note=Cytoplasmic in late spermatocytes, secondary spermatocytes and round spermatids. Gathered around metaphase chromosomes during meiotic divisions (By similarity). {ECO:0000250}.


uniprotID: Q9Y2R9
geneSymbol: MRPS7
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 242
go: ENSG00000125445;
snps: rs8075276 rs115047866
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
name:
28S ribosomal protein S7, mitochondrial (MRP-S7) (S7mt) (Mitochondrial small ribosomal subunit protein uS7m) (bMRP-27a) (bMRP27a)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]


uniprotID: Q9Y399
geneSymbol: MRPS2
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 296
go: ENSG00000122140;
snps: rs35140806 rs35293407 rs3748199
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
name:
28S ribosomal protein S2, mitochondrial (MRP-S2) (S2mt) (Mitochondrial small ribosomal subunit protein uS2m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial ribosome assembly [GO:0061668]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: P82664
geneSymbol: MRPS10
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 201
go: ENSG00000048544;
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
name:
28S ribosomal protein S10, mitochondrial (MRP-S10) (S10mt) (Mitochondrial small ribosomal subunit protein uS10m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: P82912
geneSymbol: MRPS11
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 194
go: ENSG00000181991;
snps: rs16941904 rs16941907
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
name:
28S ribosomal protein S11, mitochondrial (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) (Mitochondrial small ribosomal subunit protein uS11m)

sequence:
MQAVRNAGSRFLRSWTWPQTAGRVVARTPAGTICTGARQLQDAAAKQKVEQNAAPSHTKFSIYPPIPGEESSLRWAGKKFEEIPIAHIKASHNNTQIQVVSASNEPLAFASCGTEGFRNAKKGTGIAAQTAGIAAAARAKQKGVIHIRVVVKGLGPGRLSAMHGLIMGGLEVISITDNTPIPHNGCRPRKARKL

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; DNA damage response, detection of DNA damage [GO:0042769]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=P82912-1; Sequence=Displayed; Name=2; IsoId=P82912-2; Sequence=VSP_005719; Name=3; IsoId=P82912-3; Sequence=VSP_005720; 


uniprotID: Q9Y676
geneSymbol: MRPS18B
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 258
go: ENSG00000204568;
snps: rs34315095
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
name:
28S ribosomal protein S18b, mitochondrial (MRP-S18-b) (Mrps18-b) (S18mt-b) (28S ribosomal protein S18-2, mitochondrial) (MRP-S18-2) (Mitochondrial small ribosomal subunit protein bS18b) (Mitochondrial small ribosomal subunit protein mS40)

sequence:

opentargets:
cell junction [GO:0030054]; mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q9BYN8
geneSymbol: MRPS26
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 205
go: ENSG00000125901;
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25838379}.
name:
28S ribosomal protein S26, mitochondrial (MRP-S26) (S26mt) (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (Mitochondrial small ribosomal subunit protein mS26)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; DNA damage response, detection of DNA damage [GO:0042769]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q9NP92
geneSymbol: MRPS30
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 439
go: ENSG00000112996;
snps: rs3747479 rs35601455
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123, ECO:0000269|PubMed:28892042}.
name:
39S ribosomal protein S30, mitochondrial (MRP-S30) (S30mt) (Mitochondrial large ribosomal subunit protein mL65) (Mitochondrial large ribosomal subunit protein mS30) (Programmed cell death protein 9)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; apoptotic process [GO:0006915]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q92665
geneSymbol: MRPS31
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J9M;
length: 395
go: ENSG00000102738;
snps: rs1854421 rs13508
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279123}.
name:
28S ribosomal protein S31, mitochondrial (MRP-S31) (S31mt) (Imogen 38) (Mitochondrial small ribosomal subunit protein mS31)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial small ribosomal subunit [GO:0005763]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q9BPZ2
geneSymbol: SPIN2B
pdb: 5LUG;
name: Spindlin-2B (Spindlin-like protein 2B) (SPIN-2) (SPIN-2B)
length: 258
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12145692}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; gamete generation [GO:0007276]; regulation of cell cycle [GO:0051726]


uniprotID: Q9BUA3
geneSymbol: SPINDOC
name: Spindlin interactor and repressor of chromatin-binding protein (SPIN1-docking protein) (SPIN-DOC)
length: 381
go: ENSG00000168005;
opentargets: negative regulation of transcription, DNA-templated [GO:0045892]
snps: rs35875163
sequence:


uniprotID: Q8TCT6
geneSymbol: SPPL3
length: 384
go: ENSG00000157837;
name:
Signal peptide peptidase-like 3 (SPP-like 3) (EC 3.4.23.-) (Intramembrane protease 2) (IMP-2) (Presenilin homologous protein 1) (PSH1) (Presenilin-like protein 4)

sequence:

opentargets:
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle membrane [GO:0030660]; integral component of cytoplasmic side of endoplasmic reticulum membrane [GO:0071458]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; plasma membrane [GO:0005886]; rough endoplasmic reticulum [GO:0005791]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein proteolysis [GO:0033619]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; signal peptide processing [GO:0006465]; T cell receptor signaling pathway [GO:0050852]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=Q8TCT6-2; Sequence=Displayed; Name=3; IsoId=Q8TCT6-3; Sequence=VSP_005205; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000269|PubMed:16829952}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}.


uniprotID: Q9NUQ6
geneSymbol: SPATS2L
length: 558
go: ENSG00000196141;
name:
SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9NUQ6-1; Sequence=Displayed; Name=2; IsoId=Q9NUQ6-2; Sequence=VSP_028792; Name=3; IsoId=Q9NUQ6-3; Sequence=VSP_054241; Note=No experimental confirmation available.; Name=4; IsoId=Q9NUQ6-4; Sequence=VSP_054242; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19005571}. Nucleus, nucleolus {ECO:0000269|PubMed:19005571}. Note=During oxidative stress as well as UV irradiation, energy deprivation or heat shock, relocalizes to cytoplasmic stress granules. In the nucleus, found in structures lacking NPM1.


uniprotID: O43610
geneSymbol: SPRY3
name: Protein sprouty homolog 3 (Spry-3)
length: 288
go: ENSG00000168939;
snps: rs35474915
sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; axon development [GO:0061564]; multicellular organism development [GO:0007275]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of Ras protein signal transduction [GO:0046580]

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).


uniprotID: Q9NRC6
geneSymbol: SPTBN5
reactome: R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6807878;
name: Spectrin beta chain, non-erythrocytic 5 (Beta-V spectrin)
length: 3674
go: ENSG00000137877;
snps: rs2290559 rs2290558 rs1456235 rs1197660
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; filamentous actin [GO:0031941]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; photoreceptor connecting cilium [GO:0032391]; photoreceptor disc membrane [GO:0097381]; spectrin [GO:0008091]; actin binding [GO:0003779]; dynactin binding [GO:0034452]; dynein intermediate chain binding [GO:0045505]; kinesin binding [GO:0019894]; myosin tail binding [GO:0032029]; protein self-association [GO:0043621]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; spectrin binding [GO:0030507]; actin cytoskeleton organization [GO:0030036]; actin filament capping [GO:0051693]; axon guidance [GO:0007411]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lysosomal transport [GO:0007041]; MAPK cascade [GO:0000165]; protein homooligomerization [GO:0051260]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Detected prominently in the outer segments of photoreceptor rods and cones and in the basolateral membrane and cytosol of gastric epithelial cells.


uniprotID: Q969W0
geneSymbol: SPTSSA
reactome: R-HSA-1660661;
sequence: MAGMALARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSIVGMALYTGYVFMPQHIMAILHYFEIVQ
length: 71
go: ENSG00000165389;
name:
Serine palmitoyltransferase small subunit A (Small subunit of serine palmitoyltransferase A) (ssSPTa)

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; serine C-palmitoyltransferase complex [GO:0017059]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; sphingolipid biosynthetic process [GO:0030148]


uniprotID: Q9H5J8
geneSymbol: TAF1D
reactome: R-HSA-427359;R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 278
go: ENSG00000166012;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15520167, ECO:0000269|PubMed:17318177}.
name:
TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D)

sequence:

opentargets:
microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; RNA polymerase transcription factor SL1 complex [GO:0005668]; DNA binding [GO:0003677]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of transcription, DNA-templated [GO:0006355]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation from RNA polymerase I promoter [GO:0006361]


uniprotID: P49848
geneSymbol: TAF6
pdb: 5FUR;
length: 677
go: ENSG00000106290;
snps: rs4134897 rs727503778 rs374993554
name:
Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)

sequence:

opentargets:
cytosol [GO:0005829]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; aryl hydrocarbon receptor binding [GO:0017162]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein heterodimerization activity [GO:0046982]; RNA polymerase II activating transcription factor binding [GO:0001102]; apoptotic process [GO:0006915]; chromatin organization [GO:0006325]; DNA-templated transcription, initiation [GO:0006352]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of transcription initiation from RNA polymerase II promoter [GO:0060261]; regulation of DNA-binding transcription factor activity [GO:0051090]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha {ECO:0000303|PubMed:8262073}; IsoId=P49848-1; Sequence=Displayed; Name=2; Synonyms=Gamma {ECO:0000303|PubMed:8262073}; IsoId=P49848-2; Sequence=VSP_037476; Name=3; IsoId=P49848-3; Sequence=VSP_043709; Note=No experimental confirmation available.; Name=4; Synonyms=Delta {ECO:0000303|PubMed:11583621, ECO:0000303|PubMed:25025302}; IsoId=P49848-4; Sequence=VSP_059851; 

location:
SUBCELLULAR LOCATION: Nucleus.; SUBCELLULAR LOCATION: Isoform 4: Nucleus {ECO:0000269|PubMed:18628956}.


uniprotID: Q86TD4
geneSymbol: SRL
name: Sarcalumenin
length: 932
go: ENSG00000185739;
opentargets: sarcoplasmic reticulum lumen [GO:0033018]; GTP binding [GO:0005525]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86TD4-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q86TD4-2; Sequence=VSP_016921; Name=3; IsoId=Q86TD4-3; Sequence=VSP_059418; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Associated through calcium with the membrane. {ECO:0000250}.


uniprotID: Q9BX66
geneSymbol: SORBS1
reactome: R-HSA-445355;
pdb: 2DL3;2ECZ;2LJ0;2LJ1;2MOX;2O2W;2O31;2O9S;2O9V;4LN2;4LNP;
length: 1292
go: ENSG00000095637;
snps: rs943542 rs757431022 rs7081076 rs2281939 rs35808802
name:
Sorbin and SH3 domain-containing protein 1 (Ponsin) (SH3 domain protein 5) (SH3P12) (c-Cbl-associated protein) (CAP)

sequence:

opentargets:
cell-cell adherens junction [GO:0005913]; cell-substrate adherens junction [GO:0005924]; centrosome [GO:0005813]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; membrane raft [GO:0045121]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; stress fiber [GO:0001725]; zonula adherens [GO:0005915]; actin binding [GO:0003779]; cytoskeletal protein binding [GO:0008092]; insulin receptor binding [GO:0005158]; SH3/SH2 adaptor activity [GO:0005070]; cell-matrix adhesion [GO:0007160]; cellular response to insulin stimulus [GO:0032869]; focal adhesion assembly [GO:0048041]; insulin receptor signaling pathway [GO:0008286]; muscle contraction [GO:0006936]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of lipid biosynthetic process [GO:0046889]; positive regulation of protein localization to plasma membrane [GO:1903078]; stress fiber assembly [GO:0043149]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=12;  Name=1 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-2; Sequence=VSP_050902, VSP_050910; Name=3 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-3; Sequence=VSP_050898, VSP_050900, VSP_050906, VSP_050912, VSP_050913; Name=4 {ECO:0000269|PubMed:11374898}; IsoId=Q9BX66-4; Sequence=VSP_050895, VSP_050896, VSP_050899, VSP_050900, VSP_050903, VSP_050907, VSP_050911; Name=5 {ECO:0000269|PubMed:11532984}; IsoId=Q9BX66-5; Sequence=VSP_050896, VSP_050901, VSP_050911; Name=6 {ECO:0000269|PubMed:12504111}; IsoId=Q9BX66-6; Sequence=VSP_050896, VSP_050899, VSP_050905, VSP_050911; Name=7 {ECO:0000305}; IsoId=Q9BX66-7; Sequence=VSP_050895, VSP_050896, VSP_050900, VSP_050903, VSP_050908, VSP_050909; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648}; Name=8 {ECO:0000269|PubMed:11371513}; IsoId=Q9BX66-8; Sequence=VSP_050895, VSP_050899, VSP_050900, VSP_050904, VSP_050911; Name=9 {ECO:0000305}; IsoId=Q9BX66-9; Sequence=VSP_050899, VSP_050900, VSP_050903, VSP_050911; Name=10 {ECO:0000305}; IsoId=Q9BX66-10; Sequence=VSP_050895, VSP_050900, VSP_050903, VSP_050907, VSP_050911; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648}; Name=11; IsoId=Q9BX66-11; Sequence=VSP_050900, VSP_039210; Name=12; IsoId=Q9BX66-12; Sequence=VSP_050895, VSP_050899, VSP_041193, VSP_050900, VSP_050904, VSP_041194, VSP_050911; Note=No experimental confirmation available. Derived from mouse ortholog data. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:24275569}; 

location:
SUBCELLULAR LOCATION: Cell junction, adherens junction. Cell membrane. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus {ECO:0000250}. Nucleus matrix {ECO:0000250}. Note=Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation. {ECO:0000250}.


uniprotID: O94875
geneSymbol: SORBS2
pdb: 5VEI;
length: 1100
go: ENSG00000154556;
snps: rs725185
name:
Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; Z disc [GO:0030018]; cytoskeletal adaptor activity [GO:0008093]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=12;  Name=1; IsoId=O94875-1; Sequence=Displayed; Name=2; Synonyms=ArgBP2a; IsoId=O94875-2; Sequence=VSP_034792, VSP_034794, VSP_034798; Name=3; IsoId=O94875-3; Sequence=VSP_034795, VSP_034798; Name=4; IsoId=O94875-4; Sequence=VSP_034792, VSP_034795, VSP_034798; Name=5; Synonyms=ArgBP2b; IsoId=O94875-5; Sequence=VSP_034792, VSP_034795, VSP_034798, VSP_034799; Name=6; Synonyms=Sorbin; IsoId=O94875-6; Sequence=VSP_034791, VSP_034793, VSP_034796, VSP_034797; Name=7; IsoId=O94875-7; Sequence=VSP_043665, VSP_043666; Note=No experimental confirmation available.; Name=8; IsoId=O94875-8; Sequence=VSP_045640, VSP_045641, VSP_034798; Note=No experimental confirmation available. {ECO:0000244|PubMed:24275569}; Name=9; IsoId=O94875-9; Sequence=VSP_046219, VSP_043666, VSP_034798; Note=No experimental confirmation available. {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:24275569}; Name=10; IsoId=O94875-10; Sequence=VSP_046220, VSP_034795, VSP_034798; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648, ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:24275569, ECO:0000305}; Name=11; IsoId=O94875-11; Sequence=VSP_047056; Name=12; IsoId=O94875-12; Sequence=VSP_046219, VSP_034795, VSP_034798; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:9211900}. Apical cell membrane {ECO:0000269|PubMed:18559503}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, lamellipodium {ECO:0000269|PubMed:18559503}. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000269|PubMed:18559503}.


uniprotID: Q7Z7C8
geneSymbol: TAF8
reactome: R-HSA-6807505;
pdb: 4WV4;4WV6;5FUR;
length: 310
go: ENSG00000137413;
name:
Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; cell differentiation [GO:0030154]; inner cell mass cell proliferation [GO:0001833]; maintenance of protein location in nucleus [GO:0051457]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of fat cell differentiation [GO:0045598]; snRNA transcription by RNA polymerase II [GO:0042795]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z7C8-1; Sequence=Displayed; Name=2; IsoId=Q7Z7C8-2; Sequence=VSP_030549; Name=3; IsoId=Q7Z7C8-4; Sequence=VSP_030548; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14580349}. Cytoplasm {ECO:0000250}. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}.


uniprotID: P49458
geneSymbol: SRP9
reactome: R-HSA-1799339;
pdb: 1E8O;1E8S;1RY1;4UYJ;4UYK;5AOX;
name: Signal recognition particle 9 kDa protein (SRP9)
sequence: MPQYQTWEEFSRAAEKLYLADPMKARVVLKYRHSDGNLCVKVTDDLVCLVYKTDQAQDVKKIEKFHSQLMRLMVAKEARNVTMETE
length: 86
go: ENSG00000143742;
location: SUBCELLULAR LOCATION: Cytoplasm.
opentargets:
cytosol [GO:0005829]; signal recognition particle receptor complex [GO:0005785]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; negative regulation of translational elongation [GO:0045900]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P49458-1; Sequence=Displayed; Name=2; IsoId=P49458-2; Sequence=VSP_041270; 


uniprotID: P81877
geneSymbol: SSBP2
name: Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)
length: 361
go: ENSG00000145687;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P81877-1; Sequence=Displayed; Name=2; IsoId=P81877-2; Sequence=VSP_044744, VSP_044745; Note=No experimental confirmation available.; Name=3; IsoId=P81877-3; Sequence=VSP_045117; Name=4; IsoId=P81877-4; Sequence=VSP_044744; Note=No experimental confirmation available.; Name=5; IsoId=P81877-5; Sequence=VSP_044744, VSP_045580; Note=No experimental confirmation available.; 


uniprotID: P51649
geneSymbol: ALDH5A1
reactome: R-HSA-916853;
pdb: 2W8N;2W8O;2W8P;2W8Q;2W8R;
length: 535
go: ENSG00000112294;
drug: DB00534;DB00157;DB00139;DB00313;
location: SUBCELLULAR LOCATION: Mitochondrion.
name:
Succinate-semialdehyde dehydrogenase, mitochondrial (EC 1.2.1.24) (Aldehyde dehydrogenase family 5 member A1) (NAD(+)-dependent succinic semialdehyde dehydrogenase)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; protein homodimerization activity [GO:0042803]; succinate-semialdehyde dehydrogenase (NAD+) activity [GO:0004777]; succinate-semialdehyde dehydrogenase [NAD(P)+] activity [GO:0009013]; acetate metabolic process [GO:0006083]; central nervous system development [GO:0007417]; galactosylceramide metabolic process [GO:0006681]; gamma-aminobutyric acid catabolic process [GO:0009450]; glucose metabolic process [GO:0006006]; glucosylceramide metabolic process [GO:0006678]; glutamate metabolic process [GO:0006536]; glutamine metabolic process [GO:0006541]; glutathione metabolic process [GO:0006749]; glycerophospholipid metabolic process [GO:0006650]; neurotransmitter catabolic process [GO:0042135]; post-embryonic development [GO:0009791]; protein homotetramerization [GO:0051289]; respiratory electron transport chain [GO:0022904]; short-chain fatty acid metabolic process [GO:0046459]; succinate metabolic process [GO:0006105]

snps:
rs4646832 rs765561257 rs72552281 rs2760118 rs3765310 rs72552282 rs1326526453 rs62621664 rs145087265 rs375628463 rs72552283 rs143741652 rs118203984 rs72552284 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P51649-1; Sequence=Displayed; Name=2; IsoId=P51649-2; Sequence=VSP_045231; 


uniprotID: Q8TE77
geneSymbol: SSH3
length: 659
go: ENSG00000172830;
snps: rs7114712 rs1573536
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.
name:
Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleus [GO:0005634]; actin binding [GO:0003779]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of lamellipodium assembly [GO:0010591]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=L; IsoId=Q8TE77-1; Sequence=Displayed; Name=2; IsoId=Q8TE77-2; Sequence=VSP_016335, VSP_016336; Name=3; IsoId=Q8TE77-3; Sequence=VSP_016331, VSP_016332; Name=4; IsoId=Q8TE77-4; Sequence=VSP_016333; Note=No experimental confirmation available.; Name=5; IsoId=Q8TE77-5; Sequence=VSP_016330, VSP_016334, VSP_016335, VSP_016336; Note=No experimental confirmation available.; 


uniprotID: Q8NBB2
geneSymbol: ST20-AS1
name: Putative uncharacterized protein ST20-AS1 (ST20 antisense RNA 1) (ST20 antisense gene protein 1)
length: 130
snps: rs2733102
sequence:
MPRPASESWSPIQSRIPAYKAVSHLRLLPTANSPSGSNQPTNPNRAQHPEGPQSREGATSPVLASLEPPTPTDLPSARARPRVPAESGPGWLHKARRPTRGILRDVLRHRGVPAQPRPAPGAHQLSSPSS


uniprotID: Q9UEW8
geneSymbol: STK39
length: 545
go: ENSG00000198648;
name:
STE20/SPS1-related proline-alanine-rich protein kinase (Ste-20-related kinase) (EC 2.7.11.1) (DCHT) (Serine/threonine-protein kinase 39)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basolateral plasma membrane [GO:0016323]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; activation of MAPK activity [GO:0000187]; activation of protein kinase activity [GO:0032147]; cellular hypotonic response [GO:0071476]; cellular response to chemokine [GO:1990869]; chemokine (C-X-C motif) ligand 12 signaling pathway [GO:0038146]; intracellular signal transduction [GO:0035556]; ion homeostasis [GO:0050801]; maintenance of lens transparency [GO:0036438]; negative regulation of creatine transmembrane transporter activity [GO:1905408]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of potassium ion transmembrane transport [GO:1901380]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of sodium ion transmembrane transporter activity [GO:2000650]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion transport [GO:0043268]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of blood pressure [GO:0008217]; regulation of inflammatory response [GO:0050727]; signal transduction by protein phosphorylation [GO:0023014]; signal transduction by trans-phosphorylation [GO:0023016]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UEW8-1; Sequence=Displayed; Name=2; Synonyms=A; IsoId=Q9UEW8-2; Sequence=VSP_055889; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Nucleus when caspase-cleaved. {ECO:0000305}.


uniprotID: Q9ULZ2
geneSymbol: STAP1
pdb: 1X1F;3MAZ;
length: 295
go: ENSG00000035720;
name:
Signal-transducing adaptor protein 1 (STAP-1) (BCR downstream-signaling protein 1) (Docking protein BRDG1) (Stem cell adaptor protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; macrophage colony-stimulating factor receptor binding [GO:0005157]; phospholipid binding [GO:0005543]; phosphotyrosine residue binding [GO:0001784]; protein kinase binding [GO:0019901]; SH3/SH2 adaptor activity [GO:0005070]; transmembrane receptor protein tyrosine kinase adaptor activity [GO:0005068]; cellular response to lipopolysaccharide [GO:0071222]; negative regulation of macrophage chemotaxis [GO:0010760]; negative regulation of macrophage colony-stimulating factor signaling pathway [GO:1902227]; negative regulation of microglial cell migration [GO:1904140]; negative regulation of phosphorylation [GO:0042326]; negative regulation of ruffle assembly [GO:1900028]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of B cell receptor signaling pathway [GO:0050861]; positive regulation of gene expression [GO:0010628]; positive regulation of microglial cell activation [GO:1903980]; positive regulation of microglial cell mediated cytotoxicity [GO:1904151]; positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997]; positive regulation of phagocytosis, engulfment [GO:0060100]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17936702}. Cytoplasm {ECO:0000269|PubMed:17936702}. Mitochondrion {ECO:0000269|PubMed:17936702}.


uniprotID: O95772
geneSymbol: STARD3NL
reactome: R-HSA-196108;
name: STARD3 N-terminal-like protein (MLN64 N-terminal domain homolog)
length: 234
go: ENSG00000010270;
sequence:

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; organelle membrane contact site [GO:0044232]; cholesterol binding [GO:0015485]; protein homodimerization activity [GO:0042803]; C21-steroid hormone biosynthetic process [GO:0006700]; vesicle tethering to endoplasmic reticulum [GO:0099044]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=1; IsoId=O95772-1; Sequence=Displayed; Name=2; IsoId=O95772-2; Sequence=VSP_018819; 

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:24105263}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA and VAPB. {ECO:0000269|PubMed:24105263}.


uniprotID: Q13285
geneSymbol: NR5A1
reactome: R-HSA-383280;R-HSA-4090294;R-HSA-452723;
pdb: 1YOW;1ZDT;4QJR;4QK4;
length: 461
go: ENSG00000136931;
drug: DB04752;
name:
Steroidogenic factor 1 (SF-1) (STF-1) (hSF-1) (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; nuclear receptor activity [GO:0004879]; phospholipid binding [GO:0005543]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; steroid hormone receptor activity [GO:0003707]; transcription coactivator activity [GO:0003713]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270]; adrenal gland development [GO:0030325]; calcineurin-mediated signaling [GO:0097720]; cell differentiation [GO:0030154]; female gonad development [GO:0008585]; hormone metabolic process [GO:0042445]; hormone-mediated signaling pathway [GO:0009755]; luteinization [GO:0001553]; maintenance of protein location in nucleus [GO:0051457]; male gonad development [GO:0008584]; male sex determination [GO:0030238]; multicellular organism aging [GO:0010259]; negative regulation of female gonad development [GO:2000195]; positive regulation of gene expression [GO:0010628]; positive regulation of male gonad development [GO:2000020]; positive regulation of transcription by RNA polymerase II [GO:0045944]; primary sex determination [GO:0007538]; regulation of steroid biosynthetic process [GO:0050810]; response to gonadotropin-releasing hormone [GO:0097210]; sex determination [GO:0007530]; tissue development [GO:0009888]; transcription initiation from RNA polymerase II promoter [GO:0006367]

snps:
rs104894124 rs121918654 rs104894125 rs375469069 rs104894126 rs104894119 rs886039769 rs200163795 rs200749741 rs387906690 rs1110061 rs201095702 rs780568525 rs104894118 rs121918655 rs104894120 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:11479297, ECO:0000269|PubMed:27490115}.


uniprotID: Q9P246
geneSymbol: STIM2
pdb: 2L5Y;
name: Stromal interaction molecule 2
length: 746
go: ENSG00000109689;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; calcium channel regulator activity [GO:0005246]; calcium ion binding [GO:0005509]; store-operated calcium channel activity [GO:0015279]; activation of store-operated calcium channel activity [GO:0032237]; cellular calcium ion homeostasis [GO:0006874]; positive regulation of calcium ion transport [GO:0051928]; store-operated calcium entry [GO:0002115]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9P246-1; Sequence=Displayed; Name=2; IsoId=Q9P246-2; Sequence=VSP_057171, VSP_057172; Note=No experimental confirmation available.; Name=3; IsoId=Q9P246-3; Sequence=VSP_057173, VSP_057174; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.


uniprotID: Q9UHE8
geneSymbol: STEAP1
name: Metalloreductase STEAP1 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 1)
length: 339
go: ENSG00000164647;
snps: rs4015375 rs2888782
location: SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
cell-cell junction [GO:0005911]; endosome [GO:0005768]; endosome membrane [GO:0010008]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; channel activity [GO:0015267]; metal ion binding [GO:0046872]; oxidoreductase activity [GO:0016491]; transporter activity [GO:0005215]; ion transport [GO:0006811]; iron ion homeostasis [GO:0055072]


uniprotID: P56962
geneSymbol: STX17
reactome: R-HSA-204005;
pdb: 4WY4;
name: Syntaxin-17
length: 302
go: ENSG00000136874;
sequence:

opentargets:
autophagosome [GO:0005776]; autophagosome membrane [GO:0000421]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; integral component of membrane [GO:0016021]; Mitochondria-associated ER Membrane [GO:0044233]; mitochondrion [GO:0005739]; smooth endoplasmic reticulum membrane [GO:0030868]; SNARE complex [GO:0031201]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; autophagosome maturation [GO:0097352]; autophagosome membrane docking [GO:0016240]; endoplasmic reticulum-Golgi intermediate compartment organization [GO:0097111]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; intracellular protein transport [GO:0006886]; protein localization to phagophore assembly site [GO:0034497]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23006999}; Multi-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:23006999}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:23217709, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:26416964}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158}. Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (PubMed:23217709). May also localize to the mitochondria according to PubMed:23217709. {ECO:0000269|PubMed:23217709}.


uniprotID: Q7L7X3
geneSymbol: TAOK1
reactome: R-HSA-141444;R-HSA-2467813;R-HSA-2500257;R-HSA-5663220;R-HSA-68877;
length: 1001
go: ENSG00000160551;
snps: rs34151057
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:13679851}.
name:
Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Kinase from chicken homolog B) (hKFC-B) (MARK Kinase) (MARKK) (Prostate-derived sterile 20-like kinase 2) (PSK-2) (PSK2) (Prostate-derived STE20-like kinase 2) (Thousand and one amino acid protein kinase 1) (TAOK1) (hTAOK1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; beta-tubulin binding [GO:0048487]; kinase activity [GO:0016301]; MAP kinase kinase kinase activity [GO:0004709]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; transferase activity [GO:0016740]; activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; activation of MAPKK activity [GO:0000186]; activation of protein kinase activity [GO:0032147]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; execution phase of apoptosis [GO:0097194]; microtubule cytoskeleton organization [GO:0000226]; mitotic G2 DNA damage checkpoint [GO:0007095]; negative regulation of microtubule depolymerization [GO:0007026]; neuron cellular homeostasis [GO:0070050]; positive regulation of JNK cascade [GO:0046330]; positive regulation of protein acetylation [GO:1901985]; positive regulation of stress-activated MAPK cascade [GO:0032874]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule cytoskeleton organization [GO:0070507]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7L7X3-1; Sequence=Displayed; Name=2; IsoId=Q7L7X3-2; Sequence=VSP_015964, VSP_015965, VSP_015966; Note=No experimental confirmation available.; Name=3; IsoId=Q7L7X3-3; Sequence=VSP_043706; Note=No experimental confirmation available.; 


uniprotID: Q9UNK0
geneSymbol: STX8
name: Syntaxin-8
length: 236
go: ENSG00000170310;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endomembrane system [GO:0012505]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; recycling endosome [GO:0055037]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; ubiquitin protein ligase binding [GO:0031625]; cellular response to interferon-gamma [GO:0071346]; early endosome to late endosome transport [GO:0045022]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of protein localization to plasma membrane [GO:1903076]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity). {ECO:0000250}.


uniprotID: Q9BXA5
geneSymbol: SUCNR1
reactome: R-HSA-373076;R-HSA-418594;
name: Succinate receptor 1 (G-protein coupled receptor 91) (P2Y purinoceptor 1-like)
length: 334
go: ENSG00000198829;
drug: DB00139;
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; G protein-coupled receptor signaling pathway [GO:0007186]; glucose homeostasis [GO:0042593]; interleukin-1 beta production [GO:0032611]; macrophage activation involved in immune response [GO:0002281]; positive regulation of chemotaxis [GO:0050921]; positive regulation of inflammatory response [GO:0050729]; regulation of angiotensin metabolic process [GO:0060177]; renin secretion into blood stream [GO:0002001]; response to calcium ion [GO:0051592]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15141213}; Multi-pass membrane protein {ECO:0000269|PubMed:15141213}.


uniprotID: Q8IWU5
geneSymbol: SULF2
name: Extracellular sulfatase Sulf-2 (hSulf-2) (EC 3.1.6.-)
length: 870
go: ENSG00000196562;
snps: rs56218501 rs10048853
sequence:

opentargets:
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi stack [GO:0005795]; plasma membrane [GO:0005886]; arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; liver regeneration [GO:0097421]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of hepatocyte proliferation [GO:2000345]; response to wounding [GO:0009611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWU5-1; Sequence=Displayed; Name=2; IsoId=Q8IWU5-2; Sequence=VSP_013362; Note=May be due to a competing acceptor splice site.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.


uniprotID: Q13243
geneSymbol: SRSF5
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;
length: 272
go: ENSG00000100650;
snps: rs1057683
location: SUBCELLULAR LOCATION: Nucleus.
name:
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase B binding [GO:0043422]; RNA binding [GO:0003723]; cellular response to insulin stimulus [GO:0032869]; liver regeneration [GO:0097421]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of cell cycle [GO:0051726]; RNA export from nucleus [GO:0006405]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=SRP40-1; IsoId=Q13243-1; Sequence=Displayed; Name=SRP40-2; IsoId=Q13243-2; Sequence=VSP_005864, VSP_005865; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=SRP40-3; IsoId=Q13243-4; Sequence=Not described; Name=SRP40-4; IsoId=Q13243-3; Sequence=VSP_005863; Note=No experimental confirmation available.; 


uniprotID: P37802
geneSymbol: TAGLN2
reactome: R-HSA-114608;
pdb: 1WYM;
name: Transgelin-2 (Epididymis tissue protein Li 7e) (SM22-alpha homolog)
length: 199
go: ENSG00000158710;
snps: rs17849636
sequence:
MANRGPAYGLSREVQQKIEKQYDADLEQILIQWITTQCRKDVGRPQPGRENFQNWLKDGTVLCELINALYPEGQAPVKKIQASTMAFKQMEQISQFLQAAERYGINTTDIFQTVDLWEGKNMACVQRTLMNLGGLAVARDDGLFSGDPNWFPKKSKENPRNFSDNQLQEGKNVIGLQMGTNRGASQAGMTGYGMPRQIL

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; epithelial cell differentiation [GO:0030855]; platelet degranulation [GO:0002576]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P37802-1; Sequence=Displayed; Name=2; IsoId=P37802-2; Sequence=VSP_055311; Note=No experimental confirmation available.; 


uniprotID: P43308
geneSymbol: SSR2
reactome: R-HSA-1799339;
length: 183
go: ENSG00000163479;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
name:
Translocon-associated protein subunit beta (TRAP-beta) (Signal sequence receptor subunit beta) (SSR-beta)

sequence:
MRLLSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRIAPASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGPVVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIGIPLLLWYSSKRKYDTPKTKKN

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; cotranslational protein targeting to membrane [GO:0006613]


uniprotID: Q8N2I9
geneSymbol: STK40
pdb: 5L2Q;
length: 435
go: ENSG00000196182;
snps: rs56314546 rs755089893 rs539738963 rs3795498
name:
Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; glycogen metabolic process [GO:0005977]; lung alveolus development [GO:0048286]; lung morphogenesis [GO:0060425]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; regulation of gene expression [GO:0010468]; regulation of MAPK cascade [GO:0043408]; respiratory system process [GO:0003016]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8N2I9-1; Sequence=Displayed; Name=2; IsoId=Q8N2I9-2; Sequence=VSP_020896, VSP_020898; Note=No experimental confirmation available.; Name=3; IsoId=Q8N2I9-3; Sequence=VSP_020899, VSP_020900; Note=No experimental confirmation available.; Name=4; IsoId=Q8N2I9-4; Sequence=VSP_020897; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:13679039}. Cytoplasm {ECO:0000269|PubMed:13679039}.


uniprotID: Q8WXE9
geneSymbol: STON2
reactome: R-HSA-8856825;R-HSA-8856828;
pdb: 2JXC;
name: Stonin-2 (Stoned B)
length: 905
go: ENSG00000140022;
snps: rs3813535 rs34323725 rs35689202 rs2241621
sequence:

opentargets:
cell junction [GO:0030054]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; membrane [GO:0016020]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; synaptic vesicle [GO:0008021]; hematopoietic progenitor cell differentiation [GO:0002244]; membrane organization [GO:0061024]; regulation of endocytosis [GO:0030100]; synaptic vesicle endocytosis [GO:0048488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WXE9-1; Sequence=Displayed; Name=2; IsoId=Q8WXE9-3; Sequence=VSP_044863; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11381094}. Membrane {ECO:0000269|PubMed:11381094}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Some fraction is membrane-associated.


uniprotID: O75716
geneSymbol: STK16
pdb: 2BUJ;
length: 305
go: ENSG00000115661;
snps: rs34799131 rs35947471 rs34282267 rs17849638 rs35454203
name:
Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)

sequence:

opentargets:
cytosol [GO:0005829]; Golgi-associated vesicle [GO:0005798]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein serine/threonine kinase activity [GO:0004674]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; cellular response to transforming growth factor beta stimulus [GO:0071560]; protein autophosphorylation [GO:0046777]

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associates with Golgi and Golgi-derived vesicles. {ECO:0000250}.


uniprotID: Q86TL2
geneSymbol: STIMATE
length: 294
go: ENSG00000213533;
name:
Store-operated calcium entry regulator STIMATE (STIM-activating enhancer encoded by TMEM110) (Transmembrane protein 110)

sequence:

opentargets:
cortical endoplasmic reticulum [GO:0032541]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; calcium channel regulator activity [GO:0005246]; activation of store-operated calcium channel activity [GO:0032237]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; positive regulation of calcineurin-NFAT signaling cascade [GO:0070886]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}; Multi-pass membrane protein {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells (PubMed:26644574). May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells (Probable). {ECO:0000269|PubMed:26644574, ECO:0000305|PubMed:26322679}.


uniprotID: Q93045
geneSymbol: STMN2
name: Stathmin-2 (Superior cervical ganglion-10 protein) (Protein SCG10)
length: 179
go: ENSG00000104435;
sequence:
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG

opentargets:
cytoplasm [GO:0005737]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; lamellipodium [GO:0030027]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; calcium-dependent protein binding [GO:0048306]; tubulin binding [GO:0015631]; cellular response to nerve growth factor stimulus [GO:1990090]; microtubule depolymerization [GO:0007019]; negative regulation of microtubule depolymerization [GO:0007026]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of neuron projection development [GO:0010977]; neuron projection development [GO:0031175]; positive regulation of microtubule depolymerization [GO:0031117]; positive regulation of neuron projection development [GO:0010976]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule polymerization or depolymerization [GO:0031110]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q93045-1; Sequence=Displayed; Name=2; IsoId=Q93045-2; Sequence=VSP_045047; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon. Golgi apparatus. Endosome {ECO:0000250}. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}.


uniprotID: Q5TH74
geneSymbol: STPG1
name: O(6)-methylguanine-induced apoptosis 2 (MAPO2) (Sperm-tail PG-rich repeat-containing protein 1)
length: 334
go: ENSG00000001460;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
intracellular [GO:0005622]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; positive regulation of apoptotic process [GO:0043065]; positive regulation of mitochondrial membrane permeability involved in apoptotic process [GO:1902110]; positive regulation of protein homodimerization activity [GO:0090073]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5TH74-1; Sequence=Displayed; Name=2; IsoId=Q5TH74-2; Sequence=VSP_028252; Name=3; IsoId=Q5TH74-3; Sequence=VSP_028253, VSP_028254; 


uniprotID: Q9C0K7
geneSymbol: STRADB
reactome: R-HSA-380972;
length: 418
go: ENSG00000082146;
snps: rs35636836
name:
STE20-related kinase adapter protein beta (STRAD beta) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein) (CALS-21) (ILP-interacting protein) (Pseudokinase ALS2CR2)

sequence:

opentargets:
aggresome [GO:0016235]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; cell cycle arrest [GO:0007050]; MAPK cascade [GO:0000165]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; neuron projection morphogenesis [GO:0048812]; protein export from nucleus [GO:0006611]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=ILPIP-alpha; IsoId=Q9C0K7-1; Sequence=Displayed; Name=2; IsoId=Q9C0K7-2; Sequence=VSP_016623, VSP_016624; Note=No experimental confirmation available.; Name=3; Synonyms=ILPIP-beta; IsoId=Q9C0K7-3; Sequence=VSP_016625; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:14517248}.


uniprotID: Q03518
geneSymbol: TAP1
reactome: R-HSA-1236974;R-HSA-983170;
pdb: 1JJ7;5U1D;
length: 808
go: ENSG00000168394;
drug: DB01259;
name:
Antigen peptide transporter 1 (APT1) (ATP-binding cassette sub-family B member 2) (Peptide supply factor 1) (Peptide transporter PSF1) (PSF-1) (Peptide transporter TAP1) (Peptide transporter involved in antigen processing 1) (Really interesting new gene 4 protein)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; MHC class I peptide loading complex [GO:0042824]; microtubule organizing center [GO:0005815]; phagocytic vesicle membrane [GO:0030670]; TAP complex [GO:0042825]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; ATPase activity, coupled to transmembrane movement of substances [GO:0042626]; MHC class I protein binding [GO:0042288]; MHC class Ib protein binding [GO:0023029]; peptide antigen binding [GO:0042605]; peptide antigen-transporting ATPase activity [GO:0015433]; peptide transmembrane transporter activity [GO:1904680]; protein homodimerization activity [GO:0042803]; TAP1 binding [GO:0046978]; TAP2 binding [GO:0046979]; adaptive immune response [GO:0002250]; antigen processing and presentation of endogenous peptide antigen via MHC class I [GO:0019885]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; antigen processing and presentation of peptide antigen via MHC class I [GO:0002474]; cytosol to ER transport [GO:0046967]; defense response [GO:0006952]; peptide transport [GO:0015833]; protein transport [GO:0015031]; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane [GO:1990668]; viral process [GO:0016032]

snps:
rs375389015 rs57640466 rs2228108 rs36229525 rs2228111 rs1057141 rs2127679 rs2228110 rs41550019 rs41561219 rs1135216 rs1057149 rs121917702 rs1057149 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.


uniprotID: Q9Y6J8
geneSymbol: STYXL1
length: 313
go: ENSG00000127952;
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:21262771}.
name:
Serine/threonine/tyrosine-interacting-like protein 1 (Dual specificity phosphatase inhibitor MK-STYX) (Dual specificity protein phosphatase 24) (Inactive dual specificity protein phosphatase MK-STYX) (Map kinase phosphatase-like protein MK-STYX)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; protein phosphatase binding [GO:0019903]; protein phosphatase inhibitor activity [GO:0004864]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; pseudophosphatase activity [GO:0001691]; intracellular signal transduction [GO:0035556]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; negative regulation of stress granule assembly [GO:0062030]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; positive regulation of neuron projection development [GO:0010976]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9Y6J8-1; Sequence=Displayed; Name=2; IsoId=Q9Y6J8-2; Sequence=VSP_005178, VSP_005179; Name=3; IsoId=Q9Y6J8-3; Sequence=VSP_005180; Name=4; IsoId=Q9Y6J8-4; Sequence=VSP_005175; Name=5; IsoId=Q9Y6J8-5; Sequence=VSP_005176, VSP_005177; 


uniprotID: Q8NBJ7
geneSymbol: SUMF2
reactome: R-HSA-1660662;R-HSA-1663150;
pdb: 1Y4J;
length: 301
go: ENSG00000129103;
snps: rs4245575
name:
Inactive C-alpha-formylglycine-generating enzyme 2 (Paralog of formylglycine-generating enzyme) (pFGE) (Sulfatase-modifying factor 2)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; metal ion binding [GO:0046872]; glycosphingolipid metabolic process [GO:0006687]; post-translational protein modification [GO:0043687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8NBJ7-1; Sequence=Displayed; Name=2; IsoId=Q8NBJ7-2; Sequence=VSP_007878; Name=3; IsoId=Q8NBJ7-3; Sequence=VSP_007879; Note=No experimental confirmation available.; Name=5; IsoId=Q8NBJ7-5; Sequence=VSP_040878; Name=4; IsoId=Q8NBJ7-4; Sequence=VSP_007880; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15708861, ECO:0000269|PubMed:15962010, ECO:0000269|PubMed:18266766}.


uniprotID: Q04837
geneSymbol: SSBP1
reactome: R-HSA-2151201;
pdb: 1S3O;2DUD;3ULL;
name: Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17)
length: 148
go: ENSG00000106028;
sequence:
MFRRPVLQVLRQFVRHESETTTSLVLERSLNRVHLLGRVGQDPVLRQVEGKNPVTIFSLATNEMWRSGDSEVYQLGDVSQKTTWHRISVFRPGLRDVAYQYVKKGSRIYLEGKIDYGEYMDKNNVRRQATTIIADNIIFLSDQTKEKE

opentargets:
extracellular exosome [GO:0070062]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleoid [GO:0009295]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; RNA binding [GO:0003723]; single-stranded DNA binding [GO:0003697]; mitochondrial DNA replication [GO:0006264]; mitochondrion morphogenesis [GO:0070584]; mitochondrion organization [GO:0007005]; positive regulation of helicase activity [GO:0051096]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18063578}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.


uniprotID: Q7Z2R9
geneSymbol: SSBP3-AS1
name: Putative uncharacterized protein SSBP3-AS1 (SSBP3 antisense RNA 1) (SSBP3 antisense gene protein 1)
length: 100
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MWGFLVLKARWLVTPVRTLATEAGQKPSLRGLLDVGNIQHRAARARGLTRGVIRVSPQERSQQNQSAPKGPTPSTRPKPRTLGPQAHSLALQSVDLLFRP


uniprotID: A6NNA2
geneSymbol: SRRM3
name: Serine/arginine repetitive matrix protein 3
length: 597
opentargets: mRNA binding [GO:0003729]
sequence:


uniprotID: Q9Y6E0
geneSymbol: STK24
reactome: R-HSA-111465;R-HSA-75153;
length: 443
go: ENSG00000102572;
snps: rs55953606 rs55897869
pdb:
3A7F;3A7G;3A7H;3A7I;3A7J;3CKW;3CKX;3ZHP;4O27;4QML;4QMM;4QMN;4QMO;4QMP;4QMQ;4QMS;4QMT;4QMU;4QMV;4QMW;4QMX;4QMY;4QMZ;4QNA;4QO9;4U8Z;4W8D;4W8E;

name:
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; cellular response to starvation [GO:0009267]; execution phase of apoptosis [GO:0097194]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; MAPK cascade [GO:0000165]; negative regulation of cell migration [GO:0030336]; neuron projection morphogenesis [GO:0048812]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of axon regeneration [GO:0048679]; response to hydrogen peroxide [GO:0042542]; signal transduction [GO:0007165]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=B; IsoId=Q9Y6E0-1; Sequence=Displayed; Name=A; IsoId=Q9Y6E0-2; Sequence=VSP_004874; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Membrane. Note=The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.


uniprotID: Q8NE28
geneSymbol: STKLD1
length: 680
go: ENSG00000198870;
opentargets: ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]
snps: rs3124747 rs17150554
name:
Serine/threonine kinase-like domain-containing protein STKLD1 (Serine/threonine kinase-like domain-containing protein 1) (Sugen kinase 071)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NE28-1; Sequence=Displayed; Name=2; IsoId=Q8NE28-2; Sequence=VSP_021658, VSP_021659; Name=3; IsoId=Q8NE28-3; Sequence=VSP_021660, VSP_021657; 


uniprotID: Q9P2W9
geneSymbol: STX18
reactome: R-HSA-6811434;
name: Syntaxin-18 (Cell growth-inhibiting gene 9 protein)
length: 335
go: ENSG00000168818;
snps: rs13134070 rs36109375 rs33952588
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; SNARE complex [GO:0031201]; protein domain specific binding [GO:0019904]; SNAP receptor activity [GO:0005484]; endoplasmic reticulum membrane organization [GO:0090158]; intracellular protein transport [GO:0006886]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of organelle assembly [GO:1902117]; regulation of Golgi organization [GO:1903358]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:15029241}; Single-pass type IV membrane protein {ECO:0000305|PubMed:15029241}. Golgi apparatus membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.


uniprotID: Q6ZWJ1
geneSymbol: STXBP4
pdb: 2YSG;
name: Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (STX4-interacting protein) (Synip)
length: 553
go: ENSG00000166263;
snps: rs1156287 rs34870302
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; phagocytic vesicle [GO:0045335]; syntaxin binding [GO:0019905]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to interferon-gamma [GO:0071346]; insulin receptor signaling pathway [GO:0008286]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of keratinocyte proliferation [GO:0010838]; protein stabilization [GO:0050821]; protein targeting [GO:0006605]; regulation of glucose transmembrane transport [GO:0010827]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZWJ1-1; Sequence=Displayed; Name=2; IsoId=Q6ZWJ1-2; Sequence=VSP_017175, VSP_017176, VSP_017177, VSP_017178; 


uniprotID: G2XKQ0
geneSymbol: SUMO1P1
length: 101
name:
Small ubiquitin-related modifier 5 (SUMO-5) (SUMO1 pseudogene 1) (Ubiquitin-like 2) (Ubiquitin-like 6)

sequence:
MSDLEAKPSTEHLGDKIKDEDIKLRVIGQDSSEIHFKVKMTTPLKKLKKSYCQRQGVPVNSLRFLFEGQRIADNHTPEELGMEEEDVIEVYQEQIGGHSTV

opentargets:
nucleus [GO:0005634]; identical protein binding [GO:0042802]; transcription factor binding [GO:0008134]; PML body organization [GO:0030578]; protein sumoylation [GO:0016925]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27211601}. Note=Forms prominent non-membrane-bound structures in the nucleus. {ECO:0000269|PubMed:27211601}.


uniprotID: Q96A49
geneSymbol: SYAP1
pdb: 1X3A;
length: 352
go: ENSG00000169895;
name:
Synapse-associated protein 1 (BSD domain-containing signal transducer and Akt interactor protein) (BSTA)

sequence:

opentargets:
axon [GO:0030424]; cell junction [GO:0030054]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; Golgi apparatus [GO:0005794]; growth cone [GO:0030426]; nucleoplasm [GO:0005654]; perikaryon [GO:0043204]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; cell differentiation [GO:0030154]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; TORC2 signaling [GO:0038203]

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9D5V6}. Golgi apparatus {ECO:0000250|UniProtKB:Q9D5V6}. Perikaryon {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, axon {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9D5V6}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D5V6}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5V6}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9D5V6}. Membrane {ECO:0000269|PubMed:23300339}. Note=Localizes to cholinergic neuromuscular junctions and in actin-rich growth cone regions (By similarity). Membrane-associated in a epidermal growth factor (EGF)-dependent manner (PubMed:23300339). {ECO:0000250|UniProtKB:Q9D5V6, ECO:0000269|PubMed:23300339}.


uniprotID: Q8IYB8
geneSymbol: SUPV3L1
pdb: 3RC3;3RC8;
length: 786
go: ENSG00000156502;
snps: rs33998366 rs34596380
name:
ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)

sequence:

opentargets:
mitochondrial degradosome [GO:0045025]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP-dependent RNA helicase activity [GO:0004004]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; double-stranded RNA binding [GO:0003725]; helicase activity [GO:0004386]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; chromatin maintenance [GO:0070827]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; mitochondrial mRNA catabolic process [GO:0000958]; mitochondrial mRNA surveillance [GO:0035946]; mitochondrial ncRNA surveillance [GO:0035945]; mitochondrial RNA 3'-end processing [GO:0000965]; mitochondrial RNA surveillance [GO:2000827]; mitochondrion morphogenesis [GO:0070584]; negative regulation of apoptotic process [GO:0043066]; positive regulation of cell growth [GO:0030307]; positive regulation of mitochondrial RNA catabolic process [GO:0000962]; RNA catabolic process [GO:0006401]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17352692}. Mitochondrion matrix {ECO:0000269|PubMed:12466530, ECO:0000269|PubMed:17352692, ECO:0000269|PubMed:19864255}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:18063578}.


uniprotID: Q05952
geneSymbol: TNP2
name: Nuclear transition protein 2 (TP-2) (TP2)
length: 138
go: ENSG00000178279;
snps: rs11640138
sequence:
MDTQTHSLPITHTQLHSNSQPQSRTCTRHCQTFSQSCRQSHRGSRSQSSSQSPASHRNPTGAHSSSGHQSQSPNTSPPPKRHKKTMNSHHSPMRPTILHCRCPKNRKNLEGKLKKKKMAKRIQQVYKTKTRSSGWKSN

opentargets:
nuclear nucleosome [GO:0000788]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; acrosome reaction [GO:0007340]; multicellular organism development [GO:0007275]; penetration of zona pellucida [GO:0007341]; positive regulation of protein processing [GO:0010954]; spermatogenesis [GO:0007283]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P11378}. Chromosome {ECO:0000250|UniProtKB:P11378}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is ATP-dependent and nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000250|UniProtKB:P11378}.


uniprotID: Q15468
geneSymbol: STIL
pdb: 4YYP;5LHW;5LHZ;
name: SCL-interrupting locus protein (TAL-1-interrupting locus protein)
length: 1287
go: ENSG00000123473;
snps: rs3125630 rs398122976 rs13376679 rs3766317
sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; identical protein binding [GO:0042802]; cell proliferation [GO:0008283]; centrosome duplication [GO:0051298]; determination of left/right symmetry [GO:0007368]; embryonic axis specification [GO:0000578]; floor plate development [GO:0033504]; forebrain development [GO:0030900]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; mitotic spindle organization [GO:0007052]; multicellular organism growth [GO:0035264]; negative regulation of apoptotic process [GO:0043066]; neural tube closure [GO:0001843]; neural tube development [GO:0021915]; notochord development [GO:0030903]; protein localization to centrosome [GO:0071539]; regulation of centriole replication [GO:0046599]; smoothened signaling pathway [GO:0007224]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15468-1; Sequence=Displayed; Name=2; IsoId=Q15468-2; Sequence=VSP_022301; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q60988}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:25385835}.


uniprotID: Q14765
geneSymbol: STAT4
reactome: R-HSA-8854691;R-HSA-8862803;R-HSA-8950505;R-HSA-8984722;R-HSA-9020591;R-HSA-9020933;R-HSA-9020958;
name: Signal transducer and activator of transcription 4
length: 748
go: ENSG00000138378;
snps: rs3024839 rs3024933
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; cytokine-mediated signaling pathway [GO:0019221]; interleukin-12-mediated signaling pathway [GO:0035722]; interleukin-21-mediated signaling pathway [GO:0038114]; interleukin-23-mediated signaling pathway [GO:0038155]; interleukin-35-mediated signaling pathway [GO:0070757]; JAK-STAT cascade [GO:0007259]; positive regulation of transcription by RNA polymerase II [GO:0045944]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.


uniprotID: O75558
geneSymbol: STX11
name: Syntaxin-11
length: 287
go: ENSG00000135604;
snps: rs1802414 rs17073498 rs1133248 rs9496891
sequence:

opentargets:
endomembrane system [GO:0012505]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; presynaptic active zone membrane [GO:0048787]; presynaptic membrane [GO:0042734]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; exocytosis [GO:0006887]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; synaptic vesicle fusion to presynaptic active zone membrane [GO:0031629]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.


uniprotID: Q86Y82
geneSymbol: STX12
pdb: 2DNX;
name: Syntaxin-12
length: 276
go: ENSG00000117758;
sequence:

opentargets:
early endosome membrane [GO:0031901]; endomembrane system [GO:0012505]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; integral component of synaptic vesicle membrane [GO:0030285]; membrane raft [GO:0045121]; phagocytic vesicle [GO:0045335]; phagophore assembly site [GO:0000407]; postsynaptic recycling endosome [GO:0098837]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; autophagosome assembly [GO:0000045]; cholesterol efflux [GO:0033344]; intracellular protein transport [GO:0006886]; protein stabilization [GO:0050821]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]

location:
SUBCELLULAR LOCATION: Endosome membrane; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Golgi apparatus membrane; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}. Endomembrane system {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:G3V7P1}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:G3V7P1}.


uniprotID: Q7RTN6
geneSymbol: STRADA
reactome: R-HSA-380972;
pdb: 1UPK;2WTK;3GNI;
length: 431
go: ENSG00000266173;
snps: rs35808156 rs56271007 rs55695051
name:
STE20-related kinase adapter protein alpha (STRAD alpha) (STE20-related adapter protein) (Serologically defined breast cancer antigen NY-BR-96)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; cell cycle arrest [GO:0007050]; MAPK cascade [GO:0000165]; neuron projection morphogenesis [GO:0048812]; protein export from nucleus [GO:0006611]; signal transduction by protein phosphorylation [GO:0023014]; stress-activated protein kinase signaling cascade [GO:0031098]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1 {ECO:0000269|PubMed:12805220}; IsoId=Q7RTN6-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:14702039, ECO:0000269|Ref.2}; IsoId=Q7RTN6-2; Sequence=VSP_052219, VSP_052220, VSP_052221; Name=3 {ECO:0000269|PubMed:14702039}; IsoId=Q7RTN6-3; Sequence=VSP_052219; Name=4; IsoId=Q7RTN6-4; Sequence=VSP_043707, VSP_043708; Note=No experimental confirmation available.; Name=5; IsoId=Q7RTN6-5; Sequence=VSP_044278; Name=6; IsoId=Q7RTN6-6; Sequence=VSP_044717, VSP_043708; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}.


uniprotID: Q9NUL3
geneSymbol: STAU2
name: Double-stranded RNA-binding protein Staufen homolog 2
length: 570
go: ENSG00000040341;
snps: rs949493
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; microtubule [GO:0005874]; nucleolus [GO:0005730]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; Synonyms=Long; IsoId=Q9NUL3-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q9NUL3-2; Sequence=VSP_015374; Name=3; IsoId=Q9NUL3-3; Sequence=VSP_015374, VSP_015376, VSP_015377; Name=4; IsoId=Q9NUL3-4; Sequence=VSP_015373, VSP_015376, VSP_015377; Note=No experimental confirmation available. {ECO:0000305}; Name=5; IsoId=Q9NUL3-5; Sequence=VSP_015374, VSP_015375; Name=6; IsoId=Q9NUL3-6; Sequence=VSP_046138; Note=No experimental confirmation available.; Name=7; IsoId=Q9NUL3-7; Sequence=VSP_046139, VSP_046141; Note=No experimental confirmation available.; Name=8; IsoId=Q9NUL3-8; Sequence=VSP_046140, VSP_046142; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Endoplasmic reticulum. Note=Shuttles between the nucleolus, nucleus and the cytoplasm. Nuclear export of isoform 1 is independent of XPO1/CRM1 and requires the exportin XPO5. Nuclear export of isoform 2 and isoform 3 can occur by both XPO1/CRM1-dependent and XPO1/CRM1-independent pathways. Found in large cytoplasmic ribonucleoprotein (RNP) granules which are present in the actin rich regions of myelinating processes and associated with microtubules, polysomes and the endoplasmic reticulum. Also recruited to stress granules (SGs) upon inhibition of translation or oxidative stress. These structures are thought to harbor housekeeping mRNAs when translation is aborted (By similarity). {ECO:0000250}.


uniprotID: O75486
geneSymbol: SUPT3H
reactome: R-HSA-3214847;
name: Transcription initiation protein SPT3 homolog (SPT3-like protein)
length: 317
go: ENSG00000196284;
snps: rs16872923
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9726987}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; STAGA complex [GO:0030914]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; histone deubiquitination [GO:0016578]; histone H3 acetylation [GO:0043966]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75486-1; Sequence=Displayed; Name=2; IsoId=O75486-4; Sequence=VSP_059496; 


uniprotID: Q8IWU6
geneSymbol: SULF1
name: Extracellular sulfatase Sulf-1 (hSulf-1) (EC 3.1.6.-)
length: 871
go: ENSG00000137573;
sequence:

opentargets:
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; Golgi stack [GO:0005795]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; arylsulfatase activity [GO:0004065]; calcium ion binding [GO:0005509]; glycosaminoglycan binding [GO:0005539]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; apoptotic process [GO:0006915]; bone development [GO:0060348]; cartilage development [GO:0051216]; chondrocyte development [GO:0002063]; embryonic skeletal system development [GO:0048706]; esophagus smooth muscle contraction [GO:0014846]; glial cell-derived neurotrophic factor receptor signaling pathway [GO:0035860]; glomerular basement membrane development [GO:0032836]; glomerular filtration [GO:0003094]; heparan sulfate proteoglycan metabolic process [GO:0030201]; innervation [GO:0060384]; kidney development [GO:0001822]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of prostatic bud formation [GO:0060686]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of vascular endothelial growth factor production [GO:0010575]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of fibroblast growth factor receptor signaling pathway [GO:0040036]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Cell surface {ECO:0000250}. Note=Also localized on the cell surface. {ECO:0000250}.


uniprotID: P55854
geneSymbol: SUMO3
pdb: 1U4A;2IO1;2MP2;
length: 103
go: ENSG00000184900;
snps: rs1051311
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
reactome:
R-HSA-3065676;R-HSA-3065678;R-HSA-3065679;R-HSA-3108214;R-HSA-3232118;R-HSA-3899300;R-HSA-4090294;R-HSA-4551638;R-HSA-4615885;R-HSA-4755510;R-HSA-5696395;

name:
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)

sequence:
MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF

opentargets:
cytoplasm [GO:0005737]; kinetochore [GO:0000776]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; enzyme binding [GO:0019899]; protein tag [GO:0031386]; negative regulation of DNA binding [GO:0043392]; protein sumoylation [GO:0016925]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P55854-1; Sequence=Displayed; Name=2; IsoId=P55854-2; Sequence=VSP_054693; Note=No experimental confirmation available.; 


uniprotID: Q05519
geneSymbol: SRSF11
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;
length: 484
go: ENSG00000116754;
location: SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with spliceosome components.
name:
Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q05519-1; Sequence=Displayed; Name=2; IsoId=Q05519-2; Sequence=VSP_043376; Note=No experimental confirmation available.; 


uniprotID: Q16629
geneSymbol: SRSF7
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72165;R-HSA-72187;
pdb: 2HVZ;
length: 238
go: ENSG00000115875;
name:
Serine/arginine-rich splicing factor 7 (Splicing factor 9G8) (Splicing factor, arginine/serine-rich 7)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; cellular response to leukemia inhibitory factor [GO:1990830]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA export from nucleus [GO:0006405]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Isoforms, often lacking the RS domain and differentially expressed in fetal tissues, may be involved in modulation of 9G8 function.; Name=1; IsoId=Q16629-1; Sequence=Displayed; Name=2; IsoId=Q16629-2; Sequence=VSP_005872, VSP_005873; Name=3; IsoId=Q16629-3; Sequence=VSP_005874, VSP_005875; Name=4; IsoId=Q16629-4; Sequence=VSP_045840; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11336712}. Cytoplasm {ECO:0000269|PubMed:11336712}.


uniprotID: Q15831
geneSymbol: STK11
reactome: R-HSA-163680;R-HSA-380972;R-HSA-6804756;
pdb: 2WTK;4ZDR;5WXN;
length: 433
go: ENSG00000118046;
name:
Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; LRR domain binding [GO:0030275]; magnesium ion binding [GO:0000287]; p53 binding [GO:0002039]; protein kinase activator activity [GO:0030295]; protein serine/threonine kinase activity [GO:0004674]; activation of protein kinase activity [GO:0032147]; anoikis [GO:0043276]; autophagy [GO:0006914]; axonogenesis [GO:0007409]; canonical Wnt signaling pathway [GO:0060070]; cell cycle arrest [GO:0007050]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV-B [GO:0071493]; dendrite extension [GO:0097484]; establishment of cell polarity [GO:0030010]; glucose homeostasis [GO:0042593]; Golgi localization [GO:0051645]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; positive regulation of axonogenesis [GO:0050772]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; positive thymic T cell selection [GO:0045059]; protein autophosphorylation [GO:0046777]; protein dephosphorylation [GO:0006470]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of dendrite morphogenesis [GO:0048814]; regulation of protein kinase B signaling [GO:0051896]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to ionizing radiation [GO:0010212]; spermatogenesis [GO:0007283]; T cell receptor signaling pathway [GO:0050852]; tissue homeostasis [GO:0001894]; vasculature development [GO:0001944]

snps:
rs137853080 rs137853077 rs1057520039 rs764449808 rs137853081 rs137853078 rs730881979 rs1057520041 rs121913315 rs121913316 rs121913315 rs121913317 rs730881981 rs1057520038 rs1057520017 rs929783669 rs137853082 rs121913322 rs1057520042 rs786202431 rs367807476 rs59912467 rs587782835 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=LKB1(L); IsoId=Q15831-1; Sequence=Displayed; Name=2; Synonyms=LKB1(S); IsoId=Q15831-2; Sequence=VSP_041746; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Membrane {ECO:0000250}. Mitochondrion. Note=A small fraction localizes at membranes (By similarity). Relocates to the cytoplasm when bound to STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta). Translocates to the mitochondrion during apoptosis. Translocates to the cytoplasm in response to metformin or peroxynitrite treatment. PTEN promotes cytoplasmic localization. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:23612973}. Cytoplasm {ECO:0000269|PubMed:23612973}. Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.


uniprotID: M5A8F1
geneSymbol: ERVH48-1
length: 160
opentargets: extracellular space [GO:0005615]; syncytium formation [GO:0006949]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23492904}. Note=Also found in cell lysates.
name:
Suppressyn (Endogenous retrovirus group 48 member 1) (NDUFV3 antisense RNA 1) (endogenous retrovirus group Fb member 1)

sequence:
MACIYPTTFYTSLPTKSLNMGISLTTILILSVAVLLSTAAPPSCRECYQSLHYRGEMQQYFTYHTHIERSCYGNLIEECVESGKSYYKVKNLGVCGSRNGAICPRGKQWLCFTKIGQWGVNTQVLEDIKREQIIAKAKASKPTTPPENRPRHFHSFIQKL


uniprotID: Q13190
geneSymbol: STX5
reactome: R-HSA-204005;R-HSA-5694530;R-HSA-6807878;R-HSA-6811438;
pdb: 3EFO;
name: Syntaxin-5
length: 355
go: ENSG00000162236;
snps: rs3802945 rs11231241
sequence:

opentargets:
cytosol [GO:0005829]; endomembrane system [GO:0012505]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; SNARE complex [GO:0031201]; vesicle [GO:0031982]; cadherin binding [GO:0045296]; protein N-terminus binding [GO:0047485]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; COPII vesicle coating [GO:0048208]; early endosome to Golgi transport [GO:0034498]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi disassembly [GO:0090166]; intracellular protein transport [GO:0006886]; positive regulation of protein catabolic process [GO:0045732]; regulation of Golgi organization [GO:1903358]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking [GO:0048278]; vesicle fusion [GO:0006906]; vesicle fusion with Golgi apparatus [GO:0048280]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=4;  Name=1; IsoId=Q13190-1; Sequence=Displayed; Name=2; IsoId=Q13190-2; Sequence=VSP_020119; Note=Produced by alternative initiation at Met-55 of isoform 1.; Name=3; IsoId=Q13190-3; Sequence=VSP_020119, VSP_020120; Note=Produced by alternative splicing and alternative initiation.; Name=4; IsoId=Q13190-4; Sequence=VSP_020120; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q08851}; Single-pass type IV membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q08851}. Note=Localizes throughout the Golgi apparatus, but most abundant in the cis-most cisternae. {ECO:0000250|UniProtKB:Q08851}.


uniprotID: A6NJG2
geneSymbol: SOWAHD
length: 315
go: ENSG00000187808;
snps: rs12841259
name:
Ankyrin repeat domain-containing protein SOWAHD (Ankyrin repeat domain-containing protein 58) (Protein sosondowah homolog D)

sequence:


uniprotID: Q92537
geneSymbol: SUSD6
name: Sushi domain-containing protein 6 (Drug-activated gene overexpressed protein)
length: 303
go: ENSG00000100647;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; cell death [GO:0008219]; cellular response to DNA damage stimulus [GO:0006974]


uniprotID: Q8N300
geneSymbol: SVBP
name: Small vasohibin-binding protein (Coiled coil domain-containing protein 23)
sequence: MDPPARKEKTKVKESVSRVEKAKQKSAQQELKQRQRAEIYALNRVMTELEQQQFDEFCKQMQPPGE
length: 66
go: ENSG00000177868;
opentargets:
apical part of cell [GO:0045177]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of protein ubiquitination [GO:0031397]; protein secretion [GO:0009306]; proteolysis [GO:0006508]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99LQ4}. Secreted {ECO:0000250|UniProtKB:Q99LQ4}. Note=Detected both intracellularly and extracellularly (By similarity). Within cells, localizes mainly to the apical part of the cell (By similarity). {ECO:0000250|UniProtKB:Q99LQ4}.


uniprotID: Q9UNL2
geneSymbol: SSR3
reactome: R-HSA-1799339;
length: 185
go: ENSG00000114850;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
name:
Translocon-associated protein subunit gamma (TRAP-gamma) (Signal sequence receptor subunit gamma) (SSR-gamma)

sequence:
MAPKGSSKQQSEEDLLLQDFSRNLSAKSSALFFGNAFIVSAIPIWLYWRIWHMDLIQSAVLYSVMTLVSTYLVAFAYKNVKFVLKHKVAQKREDAVSKEVTRKLSEADNRKMSRKEKDERILWKKNEVADYEATTFSIFYNNTLFLVVVIVASFFILKNFNPTVNYILSISASSGLIALLSTGSK

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UNL2-1; Sequence=Displayed; Name=2; IsoId=Q9UNL2-2; Sequence=VSP_056195; Note=No experimental confirmation available.; 


uniprotID: Q06520
geneSymbol: SULT2A1
reactome: R-HSA-156584;R-HSA-1989781;
pdb: 1EFH;1J99;1OV4;2QP3;2QP4;3F3Y;4IFB;
length: 285
go: ENSG00000105398;
drug: DB05812;DB00316;DB01812;DB02854;DB04445;DB01708;
snps: rs11569681 rs11569679
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Bile salt sulfotransferase (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (ST2A3) (Sulfotransferase 2A1) (ST2A1)

sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; bile-salt sulfotransferase activity [GO:0047704]; estrone sulfotransferase activity [GO:0004304]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; bile acid catabolic process [GO:0030573]; ethanol catabolic process [GO:0006068]; lipid catabolic process [GO:0016042]; regulation of lipid metabolic process [GO:0019216]; steroid metabolic process [GO:0008202]; sulfation [GO:0051923]


uniprotID: Q9NY57
geneSymbol: STK32B
name: Serine/threonine-protein kinase 32B (EC 2.7.11.1) (Yet another novel kinase 2)
length: 414
go: ENSG00000152953;
snps: rs3733182 rs35207488 rs56259884 rs55961955
sequence:

opentargets:
intracellular [GO:0005622]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:10700184, ECO:0000269|PubMed:15489334}; IsoId=Q9NY57-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12975309}; IsoId=Q9NY57-2; Sequence=VSP_051997; Note=It is unsure whether Met-1 or Met-3 is the initiator. No experimental confirmation available.; 


uniprotID: Q9Y2H1
geneSymbol: STK38L
pdb: 5XQZ;
length: 464
go: ENSG00000211455;
name:
Serine/threonine-protein kinase 38-like (EC 2.7.11.1) (NDR2 protein kinase) (Nuclear Dbf2-related kinase 2)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; actin binding [GO:0003779]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; regulation of cellular component organization [GO:0051128]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2H1-1; Sequence=Displayed; Name=2; IsoId=Q9Y2H1-2; Sequence=VSP_056233, VSP_056234; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Note=Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.


uniprotID: Q8WWQ8
geneSymbol: STAB2
reactome: R-HSA-2160916;R-HSA-3000497;
pdb: 5N86;
length: 2551
go: ENSG00000136011;
drug: DB08818;
snps: rs17034186 rs12319476 rs1609860 rs17034336 rs7973658 rs17034433 rs7306642 rs2271637 rs3751197
name:
Stabilin-2 (FAS1 EGF-like and X-link domain-containing adhesion molecule 2) (Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2) (FEEL-2) (Hyaluronan receptor for endocytosis) [Cleaved into: 190 kDa form stabilin-2 (190 kDa hyaluronan receptor for endocytosis)]

sequence:

opentargets:
cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; hyaluronic acid binding [GO:0005540]; low-density lipoprotein particle binding [GO:0030169]; low-density lipoprotein particle receptor activity [GO:0005041]; protein disulfide oxidoreductase activity [GO:0015035]; scavenger receptor activity [GO:0005044]; angiogenesis [GO:0001525]; cell adhesion [GO:0007155]; defense response to bacterium [GO:0042742]; defense response to Gram-positive bacterium [GO:0050830]; endocytosis [GO:0006897]; hyaluronan catabolic process [GO:0030214]; receptor-mediated endocytosis [GO:0006898]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17675564}; Single-pass type I membrane protein {ECO:0000269|PubMed:17675564}. Cytoplasm {ECO:0000269|PubMed:17145755}. Note=Only a small amount appears to be present at the cell surface (PubMed:17145755).


uniprotID: Q7RTU9
geneSymbol: STRC
name: Stereocilin
length: 1775
go: ENSG00000242866;
snps: rs2920791
sequence:

opentargets:
cell surface [GO:0009986]; kinocilium [GO:0060091]; stereocilium tip [GO:0032426]; auditory receptor cell stereocilium organization [GO:0060088]; cell-matrix adhesion [GO:0007160]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]

location:
SUBCELLULAR LOCATION: Cell surface {ECO:0000250}. Cell projection, kinocilium {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}.


uniprotID: Q92502
geneSymbol: STARD8
reactome: R-HSA-194840;
length: 1023
go: ENSG00000130052;
snps: rs139380533 rs55962426
location: SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:17976533}.
name:
StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3)

sequence:

opentargets:
cytosol [GO:0005829]; focal adhesion [GO:0005925]; GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=DLC3beta; IsoId=Q92502-1; Sequence=Displayed; Name=2; Synonyms=DLC3alpha; IsoId=Q92502-2; Sequence=VSP_032984; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q9P2P6
geneSymbol: STARD9
name: StAR-related lipid transfer protein 9 (START domain-containing protein 9) (StARD9)
length: 4700
go: ENSG00000159433;
sequence:

opentargets:
centriole [GO:0005814]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; lipid binding [GO:0008289]; microtubule binding [GO:0008017]; microtubule motor activity [GO:0003777]; microtubule-based movement [GO:0007018]; spindle assembly [GO:0051225]

snps:
rs12594837 rs12594837 rs7161810 rs16957055 rs8030587 rs8031218 rs11857283 rs3742995 rs3742993 rs16957061 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9P2P6-1; Sequence=Displayed; Name=2; IsoId=Q9P2P6-2; Sequence=VSP_029574, VSP_029575; Note=No experimental confirmation available.; Name=3; IsoId=Q9P2P6-3; Sequence=VSP_029573, VSP_029576, VSP_029577; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22153075}. Nucleus {ECO:0000269|PubMed:22153075}. Note=Localizes throughout the cytoplasm and nucleus during interphase. Localizes to the daughter centriole during mitosis. Disappears in cytokinesis.


uniprotID: O43815
geneSymbol: STRN
name: Striatin
length: 780
go: ENSG00000115808;
sequence:

opentargets:
bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; FAR/SIN/STRIPAK complex [GO:0090443]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; armadillo repeat domain binding [GO:0070016]; calmodulin binding [GO:0005516]; estrogen receptor binding [GO:0030331]; protein phosphatase 2A binding [GO:0051721]; protein-containing complex binding [GO:0044877]; bicellular tight junction assembly [GO:0070830]; dendrite development [GO:0016358]; locomotory behavior [GO:0007626]; negative regulation of cell proliferation [GO:0008285]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43815-1; Sequence=Displayed; Name=2; IsoId=O43815-2; Sequence=VSP_023495, VSP_023496; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=CTTNBP2-binding may regulate dendritic spine distribution. {ECO:0000250}.


uniprotID: P16949
geneSymbol: STMN1
length: 149
go: ENSG00000117632;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
name:
Stathmin (Leukemia-associated phosphoprotein p18) (Metablastin) (Oncoprotein 18) (Op18) (Phosphoprotein p19) (pp19) (Prosolin) (Protein Pr22) (pp17)

sequence:
MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHIEEVRKNKESKDPADETEAD

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; membrane [GO:0016020]; microtubule [GO:0005874]; neuron projection [GO:0043005]; tubulin binding [GO:0015631]; axonogenesis [GO:0007409]; brain development [GO:0007420]; establishment of skin barrier [GO:0061436]; hepatocyte growth factor receptor signaling pathway [GO:0048012]; intracellular signal transduction [GO:0035556]; microtubule depolymerization [GO:0007019]; mitotic cytokinesis [GO:0000281]; mitotic spindle organization [GO:0007052]; negative regulation of guanyl-nucleotide exchange factor activity [GO:1905098]; negative regulation of microtubule polymerization [GO:0031115]; negative regulation of Rho protein signal transduction [GO:0035024]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of thrombin-activated receptor signaling pathway [GO:0070495]; neuron projection development [GO:0031175]; positive regulation of cellular component movement [GO:0051272]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule polymerization or depolymerization [GO:0031110]; response to virus [GO:0009615]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P16949-1; Sequence=Displayed; Name=2; IsoId=P16949-2; Sequence=VSP_041377; Note=No experimental confirmation available.; 


uniprotID: Q76I76
geneSymbol: SSH2
pdb: 2NT2;
length: 1423
go: ENSG00000141298;
snps: rs2289629 rs6505140 rs8080046
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
name:
Protein phosphatase Slingshot homolog 2 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 2) (SSH-2L) (hSSH-2L)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular space [GO:0005615]; actin binding [GO:0003779]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; actin cytoskeleton organization [GO:0030036]; protein dephosphorylation [GO:0006470]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of axonogenesis [GO:0050770]; regulation of lamellipodium assembly [GO:0010591]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=L; IsoId=Q76I76-1; Sequence=Displayed; Name=2; IsoId=Q76I76-2; Sequence=VSP_016321, VSP_016322, VSP_016323; Name=3; Synonyms=A; IsoId=Q76I76-3; Sequence=VSP_016322, VSP_016323; Name=4; IsoId=Q76I76-4; Sequence=VSP_016324, VSP_016325; Note=No experimental confirmation available.; 


uniprotID: Q9NUC0
geneSymbol: SERTAD4
name: SERTA domain-containing protein 4
length: 356
go: ENSG00000082497;
opentargets: nucleus [GO:0005634]
sequence:


uniprotID: Q16384
geneSymbol: SSX1
name: Protein SSX1 (Cancer/testis antigen 5.1) (CT5.1) (Synovial sarcoma, X breakpoint 1)
length: 188
go: ENSG00000126752;
sequence:
MNGDDTFAKRPRDDAKASEKRSKAFDDIATYFSKKEWKKMKYSEKISYVYMKRNYKAMTKLGFKVTLPPFMCNKQATDFQGNDFDNDHNRRIQVEHPQMTFGRLHRIIPKIMPKKPAEDENDSKGVSEASGPQNDGKQLHPPGKANISEKINKRSGPKRGKHAWTHRLRERKQLVIYEEISDPEEDDE

opentargets:
nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; transcription corepressor activity [GO:0003714]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: P42229
geneSymbol: STAT5A
name: Signal transducer and activator of transcription 5A
length: 794
go: ENSG00000126561;
snps: rs2230134
reactome:
R-HSA-1170546;R-HSA-1251985;R-HSA-1266695;R-HSA-1433557;R-HSA-1839117;R-HSA-186763;R-HSA-2586552;R-HSA-512988;R-HSA-8854691;R-HSA-8983432;R-HSA-8985947;R-HSA-9020558;R-HSA-9020958;R-HSA-982772;

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein tyrosine kinase activity [GO:0004713]; 2-oxoglutarate metabolic process [GO:0006103]; allantoin metabolic process [GO:0000255]; citrate metabolic process [GO:0006101]; creatine metabolic process [GO:0006600]; creatinine metabolic process [GO:0046449]; cytokine-mediated signaling pathway [GO:0019221]; fatty acid metabolic process [GO:0006631]; interleukin-15-mediated signaling pathway [GO:0035723]; interleukin-2-mediated signaling pathway [GO:0038110]; interleukin-7-mediated signaling pathway [GO:0038111]; interleukin-9-mediated signaling pathway [GO:0038113]; isoleucine metabolic process [GO:0006549]; JAK-STAT cascade [GO:0007259]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; lactation [GO:0007595]; oxaloacetate metabolic process [GO:0006107]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of endothelial cell proliferation [GO:0001938]; regulation of multicellular organism growth [GO:0040014]; regulation of transcription by RNA polymerase II [GO:0006357]; succinate metabolic process [GO:0006105]; taurine metabolic process [GO:0019530]; valine metabolic process [GO:0006573]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P42229-1; Sequence=Displayed; Name=2; IsoId=P42229-2; Sequence=VSP_053332; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15534001}. Nucleus {ECO:0000269|PubMed:15534001}. Note=Translocated into the nucleus in response to phosphorylation.


uniprotID: P78524
geneSymbol: ST5
reactome: R-HSA-8876198;
length: 1137
go: ENSG00000166444;
snps: rs3794153 rs3812762 rs17853683 rs11042047 rs17853682
name:
Suppression of tumorigenicity 5 protein (DENN domain-containing protein 2B) (HeLa tumor suppression 1)

sequence:

opentargets:
Rab guanyl-nucleotide exchange factor activity [GO:0017112]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=3;  Name=1; Synonyms=p126; IsoId=P78524-1; Sequence=Displayed; Note=Produced by alternative promoter usage.; Name=2; Synonyms=p82; IsoId=P78524-2; Sequence=VSP_019988; Note=Produced by alternative splicing of isoform 1.; Name=3; Synonyms=p70; IsoId=P78524-3; Sequence=VSP_019987; Note=Produced by alternative promoter usage.; 


uniprotID: O94864
geneSymbol: SUPT7L
reactome: R-HSA-3214847;
length: 414
go: ENSG00000119760;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863}.
name:
STAGA complex 65 subunit gamma (Adenocarcinoma antigen ART1) (SPTF-associated factor 65 gamma) (STAF65gamma) (Suppressor of Ty 7-like)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; STAGA complex [GO:0030914]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; histone H3 acetylation [GO:0043966]; maintenance of protein location in nucleus [GO:0051457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O94864-1; Sequence=Displayed; Name=2; IsoId=O94864-2; Sequence=VSP_003974; Note=No experimental confirmation available.; Name=3; IsoId=O94864-4; Sequence=VSP_054839; Note=No experimental confirmation available.; 


uniprotID: O00338
geneSymbol: SULT1C2
reactome: R-HSA-156584;
pdb: 3BFX;
name: Sulfotransferase 1C2 (ST1C2) (EC 2.8.2.-) (Sulfotransferase 1C1) (SULT1C#1) (humSULTC2)
length: 296
go: ENSG00000198203;
snps: rs17036091 rs17036104 rs45515691
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; sulfation [GO:0051923]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Short; IsoId=O00338-1; Sequence=Displayed; Name=Long; IsoId=O00338-2; Sequence=VSP_006303; 


uniprotID: Q6IMI6
geneSymbol: SULT1C3
pdb: 2H8K;2REO;
name: Sulfotransferase 1C3 (ST1C3) (EC 2.8.2.2)
length: 304
go: ENSG00000196228;
snps: rs11903659 rs17035911 rs2219078 rs6722745
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; alcohol sulfotransferase activity [GO:0004027]; aryl sulfotransferase activity [GO:0004062]; sulfur compound metabolic process [GO:0006790]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=The SULT1C3 gene contains duplicated exons that could give rise to 4 potential isoforms. So far, it is not known which isoforms are expressed.; Name=1; Synonyms=D, SULT1C3d; IsoId=Q6IMI6-1; Sequence=Displayed; Name=2; Synonyms=A, SULT1C3a; IsoId=Q6IMI6-2; Sequence=VSP_020583; 


uniprotID: O95210
geneSymbol: STBD1
reactome: R-HSA-6798695;
name: Starch-binding domain-containing protein 1 (Genethonin-1) (Glycophagy cargo receptor STBD1)
length: 358
go: ENSG00000118804;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ficolin-1-rich granule membrane [GO:0101003]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; phagophore assembly site membrane [GO:0034045]; plasma membrane [GO:0005886]; T-tubule [GO:0030315]; tertiary granule membrane [GO:0070821]; enzyme binding [GO:0019899]; glycogen binding [GO:2001069]; polysaccharide binding [GO:0030247]; starch binding [GO:2001070]; glycogen catabolic process [GO:0005980]; glycophagy [GO:0061723]; intracellular transport [GO:0046907]; neutrophil degranulation [GO:0043312]

location:
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:20810658, ECO:0000305|PubMed:21893048}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24837458}; Single-pass type III membrane protein {ECO:0000305|PubMed:9794794}. Note=Distributed in the transverse tubules and/or near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048). {ECO:0000269|PubMed:21893048, ECO:0000269|PubMed:9794794}.


uniprotID: Q8N7X2
geneSymbol: STPG3
name: Protein STPG3 (Sperm-tail PG-rich repeat-containing protein 3)
length: 386
go: ENSG00000197768;
snps: rs28657439
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=2; IsoId=Q8N7X2-2; Sequence=Displayed; Name=1; IsoId=Q8N7X2-1; Sequence=VSP_059448; Note=Dubious isoform produced through aberrant splice sites. {ECO:0000305}; Name=3; IsoId=Q8N7X2-3; Sequence=VSP_059447; Name=4; IsoId=Q8N7X2-4; Sequence=VSP_059449; 


uniprotID: P52630
geneSymbol: STAT2
reactome: R-HSA-8854691;R-HSA-909733;R-HSA-912694;
pdb: 2KA4;
name: Signal transducer and activator of transcription 2 (p113)
length: 851
go: ENSG00000170581;
snps: rs2066816 rs2066817 rs2228259 rs2066815 rs2066811 rs2066809 rs2066807 rs2229363
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; ubiquitin-like protein ligase binding [GO:0044389]; cytokine-mediated signaling pathway [GO:0019221]; defense response to virus [GO:0051607]; JAK-STAT cascade [GO:0007259]; regulation of mitochondrial fission [GO:0090140]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]; type I interferon signaling pathway [GO:0060337]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P52630-3; Sequence=Displayed; Name=2; IsoId=P52630-4; Sequence=VSP_046705; Note=No experimental confirmation available. May be due to competing acceptor splice site.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419, ECO:0000269|PubMed:27782195}. Nucleus {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. {ECO:0000269|PubMed:11150296, ECO:0000269|PubMed:23139419}.


