# annotation

uniprotID: Q5JNZ5
geneSymbol: RPS26P11
name: Putative 40S ribosomal protein S26-like 1
length: 115
sequence:
MTKKRRNNSHAKKGRGHVQPIRCTNCVRCVPTDKAIKKFVIRNIVEAAAVRDISEVSVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREACKDRTPPPRFRPAGAAPRPPPKPM

opentargets:
cytosolic small ribosomal subunit [GO:0022627]; mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]


uniprotID: Q71UM5
geneSymbol: RPS27L
name: 40S ribosomal protein S27-like (Small ribosomal subunit protein eS27-like)
sequence: MPLARDLLHPSLEEEKKKHKKKRLVQSPNSYFMDVKCPGCYKITTVFSHAQTVVLCVGCSTVLCQPTGGKARLTEGCSFRRKQH
length: 84
go: ENSG00000185088;
opentargets:
cytosolic small ribosomal subunit [GO:0022627]; nucleus [GO:0005634]; cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation activator activity [GO:0008494]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [GO:0006978]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; mitotic G1 DNA damage checkpoint [GO:0031571]; positive regulation of translation [GO:0045727]; ribosomal small subunit assembly [GO:0000028]; translation [GO:0006412]


uniprotID: O43159
geneSymbol: RRP8
reactome: R-HSA-427359;
pdb: 2ZFU;
name: Ribosomal RNA-processing protein 8 (EC 2.1.1.-) (Cerebral protein 1) (Nucleomethylin)
length: 456
go: ENSG00000132275;
snps: rs11040934 rs17834692
sequence:

opentargets:
chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; rDNA heterochromatin [GO:0033553]; methylated histone binding [GO:0035064]; RNA binding [GO:0003723]; S-adenosylmethionine-dependent methyltransferase activity [GO:0008757]; cellular response to glucose starvation [GO:0042149]; chromatin silencing at rDNA [GO:0000183]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; positive regulation of cell cycle arrest [GO:0071158]; regulation of transcription by glucose [GO:0046015]; rRNA processing [GO:0006364]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus.


uniprotID: P08708
geneSymbol: RPS17
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S17 (Small ribosomal subunit protein eS17)
length: 135
go: ENSG00000182774;
snps: rs1043734
sequence:
MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKRIQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVTQPTVGMNFKTPRGPV

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; erythrocyte homeostasis [GO:0034101]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P15880
geneSymbol: RPS2
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6G18;6G4S;6G51;6G53;6G5H;6G5I;
length: 293
go: ENSG00000140988;
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-3214858;R-HSA-6790901;R-HSA-6791226;R-HSA-72649;R-HSA-72689;R-HSA-72695;R-HSA-72702;R-HSA-72706;R-HSA-72764;R-HSA-8876725;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

name:
40S ribosomal protein S2 (40S ribosomal protein S4) (Protein LLRep3) (Small ribosomal subunit protein uS5)

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; fibroblast growth factor binding [GO:0017134]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: A8MT33
geneSymbol: SYCE1L
name: Synaptonemal complex central element protein 1-like (Meiosis-related protein)
length: 242
go: ENSG00000205078;
sequence:

opentargets:
intermediate filament cytoskeleton [GO:0045111]; synaptonemal complex [GO:0000795]; synaptonemal complex assembly [GO:0007130]


uniprotID: P62857
geneSymbol: RPS28
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S28 (Small ribosomal subunit protein eS28)
sequence: MDTSRVQPIKLARVTKVLGRTGSQGQCTQVRVEFMDDTSRSIIRNVKGPVREGDVLTLLESEREARRLR
length: 69
go: ENSG00000233927;
opentargets:
cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; maturation of SSU-rRNA [GO:0030490]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit assembly [GO:0000028]; ribosomal small subunit biogenesis [GO:0042274]; ribosome biogenesis [GO:0042254]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAT1}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6QAT1, ECO:0000269|PubMed:25957688}.


uniprotID: P62861
geneSymbol: FAU
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5OA3;5T2C;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S30 (Small ribosomal subunit protein eS30)
sequence: KVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS
length: 59
opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular space [GO:0005615]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P62847
geneSymbol: RPS24
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S24 (Small ribosomal subunit protein eS24)
length: 133
go: ENSG00000138326;
sequence:
MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; translation initiation factor binding [GO:0031369]; erythrocyte homeostasis [GO:0034101]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P62847-1, P16632-1; Sequence=Displayed; Name=2; IsoId=P62847-2, P16632-2; Sequence=VSP_005724; Name=3; IsoId=P62847-3; Sequence=VSP_039113; Name=4; IsoId=P62847-4; Sequence=VSP_045672; Note=No experimental confirmation available.; 


uniprotID: P62269
geneSymbol: RPS18
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S18 (Ke-3) (Ke3) (Small ribosomal subunit protein uS13)
length: 152
go: ENSG00000231500;
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:
MSLVIPEKFQHILRVLNTNIDGRRKIAFAITAIKGVGRRYAHVVLRKADIDLTKRAGELTEDEVERVITIMQNPRQYKIPDWFLNRQKDVKDGKYSQVLANGLDNKLREDLERLKKIRAHRGLRHFWGLRVRGQHTKTTGRRGRTVGVSKKK

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P62701
geneSymbol: RPS4X
pdb: 4UG0;4V6X;5A2Q;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
length: 263
go: ENSG00000198034;
name:
40S ribosomal protein S4, X isoform (SCR10) (Single copy abundant mRNA protein) (Small ribosomal subunit protein eS4)

sequence:

opentargets:
cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; synapse [GO:0045202]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; multicellular organism development [GO:0007275]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell proliferation [GO:0008284]; positive regulation of translation [GO:0045727]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P60866
geneSymbol: RPS20
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S20 (Small ribosomal subunit protein uS10)
length: 119
go: ENSG00000008988;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:
MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P60866-1; Sequence=Displayed; Name=2; IsoId=P60866-2; Sequence=VSP_042724; Note=No experimental confirmation available.; 


uniprotID: P62979
geneSymbol: RPS27A
length: 156
go: ENSG00000143947;
location: SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
reactome:
R-HSA-110312;R-HSA-110314;R-HSA-110320;R-HSA-1169091;R-HSA-1169408;R-HSA-1234176;R-HSA-1236382;R-HSA-1236974;R-HSA-1253288;R-HSA-1295596;R-HSA-1358803;R-HSA-156827;R-HSA-156902;R-HSA-162588;R-HSA-168638;R-HSA-168927;R-HSA-168928;R-HSA-174048;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-174490;R-HSA-175474;R-HSA-179409;R-HSA-1799339;R-HSA-180534;R-HSA-180585;R-HSA-182971;R-HSA-187577;R-HSA-192823;R-HSA-195253;R-HSA-201681;R-HSA-202424;R-HSA-205043;R-HSA-209543;R-HSA-209560;R-HSA-211733;R-HSA-2122947;R-HSA-2122948;R-HSA-2173788;R-HSA-2173791;R-HSA-2173795;R-HSA-2173796;R-HSA-2408557;R-HSA-2467813;R-HSA-2559580;R-HSA-2559582;R-HSA-2559585;R-HSA-2565942;R-HSA-2644606;R-HSA-2672351;R-HSA-2691232;R-HSA-2871837;R-HSA-2894862;R-HSA-2979096;R-HSA-3134975;R-HSA-3322077;R-HSA-349425;R-HSA-3769402;R-HSA-3785653;R-HSA-382556;R-HSA-400253;R-HSA-445989;R-HSA-450302;R-HSA-450321;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-4641263;R-HSA-5205685;R-HSA-532668;R-HSA-5357905;R-HSA-5357956;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5654726;R-HSA-5654727;R-HSA-5654732;R-HSA-5654733;R-HSA-5655862;R-HSA-5656121;R-HSA-5656169;R-HSA-5658442;R-HSA-5668541;R-HSA-5675221;R-HSA-5675482;R-HSA-5676590;R-HSA-5678895;R-HSA-5684264;R-HSA-5685942;R-HSA-5687128;R-HSA-5689603;R-HSA-5689877;R-HSA-5689880;R-HSA-5689896;R-HSA-5689901;R-HSA-5693565;R-HSA-5693607;R-HSA-5696394;R-HSA-5696395;R-HSA-5696397;R-HSA-5696400;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6783310;R-HSA-6791226;R-HSA-6804756;R-HSA-6804757;R-HSA-6804760;R-HSA-6807004;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69231;R-HSA-69481;R-HSA-69541;R-HSA-69601;R-HSA-72649;R-HSA-72689;R-HSA-72695;R-HSA-72702;R-HSA-72706;R-HSA-72764;R-HSA-8849469;R-HSA-8852276;R-HSA-8854050;R-HSA-8856825;R-HSA-8856828;R-HSA-8863795;R-HSA-8866652;R-HSA-8866654;R-HSA-8875360;R-HSA-8876493;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948747;R-HSA-8948751;R-HSA-8951664;R-HSA-901032;R-HSA-9010553;R-HSA-9013507;R-HSA-9013973;R-HSA-9014325;R-HSA-9020702;R-HSA-9033241;R-HSA-912631;R-HSA-917729;R-HSA-917937;R-HSA-936440;R-HSA-936964;R-HSA-937039;R-HSA-937041;R-HSA-937042;R-HSA-937072;R-HSA-9604323;R-HSA-975110;R-HSA-975144;R-HSA-975163;R-HSA-975956;R-HSA-975957;R-HSA-977225;R-HSA-983168;

pdb:
2KHW;2KOX;2KTF;2KWU;2KWV;2L0F;2L0T;2XK5;3AXC;3I3T;3K9P;3N30;3N32;3NHE;3NOB;3NS8;3PHD;3PHW;3TBL;3VDZ;4R62;4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5T2C;5WVO;5YDK;6EK0;6FEC;6G18;6G51;6G53;

name:
Ubiquitin-40S ribosomal protein S27a (Ubiquitin carboxyl extension protein 80) [Cleaved into: Ubiquitin; 40S ribosomal protein S27a (Small ribosomal subunit protein eS31)]

sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; host cell [GO:0043657]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; small ribosomal subunit [GO:0015935]; vesicle [GO:0031982]; metal ion binding [GO:0046872]; protein tag [GO:0031386]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625]; activation of MAPK activity [GO:0000187]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular protein metabolic process [GO:0044267]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, detection of DNA damage [GO:0042769]; endosomal transport [GO:0016197]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; global genome nucleotide-excision repair [GO:0070911]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; interleukin-1-mediated signaling pathway [GO:0070498]; interstrand cross-link repair [GO:0036297]; intracellular transport of virus [GO:0075733]; JNK cascade [GO:0007254]; membrane organization [GO:0061024]; modification-dependent protein catabolic process [GO:0019941]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; protein polyubiquitination [GO:0000209]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]; regulation of mRNA stability [GO:0043488]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; stress-activated MAPK cascade [GO:0051403]; transcription-coupled nucleotide-excision repair [GO:0006283]; transforming growth factor beta receptor signaling pathway [GO:0007179]; translation [GO:0006412]; translational initiation [GO:0006413]; translesion synthesis [GO:0019985]; transmembrane transport [GO:0055085]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; viral life cycle [GO:0019058]; virion assembly [GO:0019068]; Wnt signaling pathway [GO:0016055]


uniprotID: P23396
geneSymbol: RPS3
pdb: 1WH9;4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S3 (EC 4.2.99.18) (Small ribosomal subunit protein uS3)
length: 243
go: ENSG00000149273;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; mitochondrial inner membrane [GO:0005743]; mitochondrial matrix [GO:0005759]; mitotic spindle [GO:0072686]; NF-kappaB complex [GO:0071159]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polysome [GO:0005844]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; ruffle membrane [GO:0032587]; class I DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0140078]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; DNA-(apurinic or apyrimidinic site) endonuclease activity [GO:0003906]; endodeoxyribonuclease activity [GO:0004520]; enzyme binding [GO:0019899]; Hsp70 protein binding [GO:0030544]; Hsp90 protein binding [GO:0051879]; iron-sulfur cluster binding [GO:0051536]; kinase binding [GO:0019900]; microtubule binding [GO:0008017]; mRNA binding [GO:0003729]; oxidized purine DNA binding [GO:0032357]; oxidized purine nucleobase lesion DNA N-glycosylase activity [GO:0008534]; oxidized pyrimidine DNA binding [GO:0032358]; protein kinase A binding [GO:0051018]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; small ribosomal subunit rRNA binding [GO:0070181]; structural constituent of ribosome [GO:0003735]; supercoiled DNA binding [GO:0097100]; transcription factor binding [GO:0008134]; tubulin binding [GO:0015631]; ubiquitin-like protein conjugating enzyme binding [GO:0044390]; apoptotic process [GO:0006915]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to tumor necrosis factor [GO:0071356]; chromosome segregation [GO:0007059]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; negative regulation of DNA repair [GO:0045738]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of translation [GO:0017148]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of activated T cell proliferation [GO:0042104]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of base-excision repair [GO:1905053]; positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis [GO:2001272]; positive regulation of DNA N-glycosylase activity [GO:1902546]; positive regulation of DNA repair [GO:0045739]; positive regulation of endodeoxyribonuclease activity [GO:0032079]; positive regulation of gene expression [GO:0010628]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of T cell receptor signaling pathway [GO:0050862]; regulation of apoptotic process [GO:0042981]; response to oxidative stress [GO:0006979]; response to TNF agonist [GO:0061481]; spindle assembly [GO:0051225]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P23396-1; Sequence=Displayed; Name=2; IsoId=P23396-2; Sequence=VSP_046667; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus {ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:19460357, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus, nucleolus {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:19460357}. Mitochondrion inner membrane {ECO:0000269|PubMed:23911537}; Peripheral membrane protein {ECO:0000269|PubMed:23911537}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23131551}. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (PubMed:23131551). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000250|UniProtKB:P62908, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:23131551, ECO:0000269|PubMed:23911537}.


uniprotID: P62273
geneSymbol: RPS29
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S29 (Small ribosomal subunit protein uS14)
sequence: MGHQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGFIKLD
length: 56
go: ENSG00000213741;
snps: rs587777568 rs587777569
opentargets:
cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; structural constituent of ribosome [GO:0003735]; zinc ion binding [GO:0008270]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P62273-1; Sequence=Displayed; Name=2; IsoId=P62273-2; Sequence=VSP_042844; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q6QAP6}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q6QAP6, ECO:0000269|PubMed:25957688}.


uniprotID: P62851
geneSymbol: RPS25
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S25 (Small ribosomal subunit protein eS25)
length: 125
go: ENSG00000118181;
sequence:
MPPKDDKKKKDAGKSAKKDKDPVNKSGGKAKKKKWSKGKVRDKLNNLVLFDKATYDKLCKEVPNYKLITPAVVSERLKIRGSLARAALQELLSKGLIKLVSKHRAQVIYTRNTKGGDAPAAGEDA

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribosome [GO:0005840]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P62854
geneSymbol: RPS26
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6G5H;
name: 40S ribosomal protein S26 (Small ribosomal subunit protein eS26)
length: 115
go: ENSG00000197728;
snps: rs267607023
sequence:
MTKKRRNNGRAKKGRGHVQPIRCTNCARCVPKDKAIKKFVIRNIVEAAAVRDISEASVFDAYVLPKLYVKLHYCVSCAIHSKVVRNRSREARKDRTPPPRFRPAGAAPRPPPKPM

opentargets:
cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; polysomal ribosome [GO:0042788]; small ribosomal subunit [GO:0015935]; cadherin binding [GO:0045296]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; negative regulation of RNA splicing [GO:0033119]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P49171}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49171, ECO:0000269|PubMed:25957688}.


uniprotID: P61247
geneSymbol: RPS3A
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
length: 264
go: ENSG00000145425;
name:
40S ribosomal protein S3a (Small ribosomal subunit protein eS1) (v-fos transformation effector protein) (Fte-1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cell differentiation [GO:0030154]; negative regulation of apoptotic process [GO:0043066]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122, ECO:0000269|PubMed:17289661}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03122}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.


uniprotID: A1L190
geneSymbol: SYCE3
reactome: R-HSA-1221632;
name: Synaptonemal complex central element protein 3 (Testis highly expressed gene 2 protein) (THEG-2)
sequence: MDDADPEERNYDNMLKMLSDLNKDLEKLLEEMEKISVQATWMAYDMVVMRTNPTLAESMRRLEDAFVNCKEEMEKNWQELLHETKQRL
length: 88
go: ENSG00000217442;
snps: rs6009989
opentargets:
central element [GO:0000801]; chromosome [GO:0005694]; nucleus [GO:0005634]; cell division [GO:0051301]; positive regulation of apoptotic process [GO:0043065]; reciprocal meiotic recombination [GO:0007131]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B5KM66}. Chromosome {ECO:0000250|UniProtKB:B5KM66}. Note=Colocalizes with SYCE1 in the central elements. {ECO:0000250|UniProtKB:B5KM66}.


uniprotID: Q9HA77
geneSymbol: CARS2
reactome: R-HSA-379726;
name: Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
length: 564
go: ENSG00000134905;
drug: DB00151;
snps: rs557671802 rs965189 rs1043886
location: SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrial matrix [GO:0005759]; ATP binding [GO:0005524]; cysteine-tRNA ligase activity [GO:0004817]; metal ion binding [GO:0046872]; cysteinyl-tRNA aminoacylation [GO:0006423]


uniprotID: Q15431
geneSymbol: SYCP1
reactome: R-HSA-1221632;
pdb: 4YTO;6F5X;6F62;6F63;6F64;
name: Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8)
length: 976
go: ENSG00000198765;
snps: rs12563933 rs1053812
sequence:

opentargets:
central element [GO:0000801]; chromosome, centromeric region [GO:0000775]; male germ cell nucleus [GO:0001673]; synaptonemal complex [GO:0000795]; transverse filament [GO:0000802]; DNA binding [GO:0003677]; cell division [GO:0051301]; chiasma assembly [GO:0051026]; lateral element assembly [GO:0051878]; meiotic DNA repair synthesis [GO:0000711]; reciprocal meiotic recombination [GO:0007131]; regulation of protein localization [GO:0032880]; sperm chromatin condensation [GO:0035092]; spermatogenesis [GO:0007283]; synapsis [GO:0007129]; synaptonemal complex assembly [GO:0007130]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62209}. Chromosome {ECO:0000250|UniProtKB:Q62209}. Chromosome, centromere {ECO:0000250|UniProtKB:Q62209}. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity). {ECO:0000250|UniProtKB:Q03410, ECO:0000250|UniProtKB:Q62209}.


uniprotID: P46782
geneSymbol: RPS5
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
length: 204
go: ENSG00000083845;
name:
40S ribosomal protein S5 (Small ribosomal subunit protein uS7) [Cleaved into: 40S ribosomal protein S5, N-terminally processed]

sequence:

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; ribonucleoprotein complex [GO:1990904]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; regulation of translational fidelity [GO:0006450]; ribosomal small subunit assembly [GO:0000028]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q0VAF6
geneSymbol: SYCN
name: Syncollin (Insulin synthesis-associated protein 1)
length: 134
go: ENSG00000179751;
snps: rs2082416
sequence:
MSPLRPLLLALALASVPCAQGACPASADLKHSDGTRTCAKLYDKSDPYYENCCGGAELSLESGADLPYLPSNWANTASSLVVAPRCELTVWSRQGKAGKTHKFSAGTYPRLEEYRRGILGDWSNAISALYCRCS

opentargets:
secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; exocytosis [GO:0006887]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Note=Localizes to zymogen granules. Associated with lipid rafts in a cholesterol-dependent manner. {ECO:0000250}.


uniprotID: Q6PIF2
geneSymbol: SYCE2
reactome: R-HSA-1221632;
name: Synaptonemal complex central element protein 2 (Central element synaptonemal complex protein 1)
length: 218
go: ENSG00000161860;
sequence:

opentargets:
central element [GO:0000801]; nucleus [GO:0005634]; cell division [GO:0051301]; synaptonemal complex assembly [GO:0007130]

location:
SUBCELLULAR LOCATION: Nucleus. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE1 in the central elements (By similarity). {ECO:0000250}.


uniprotID: P62081
geneSymbol: RPS7
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S7 (Small ribosomal subunit protein eS7)
length: 194
go: ENSG00000171863;
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-6790901;R-HSA-6791226;R-HSA-72649;R-HSA-72689;R-HSA-72695;R-HSA-72702;R-HSA-72706;R-HSA-72764;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

sequence:
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; focal adhesion [GO:0005925]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; small-subunit processome [GO:0032040]; synapse [GO:0045202]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; poly(U) RNA binding [GO:0008266]; protein kinase binding [GO:0019901]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; cell differentiation [GO:0030154]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neural tube closure [GO:0001843]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of gene expression [GO:0010628]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; protein stabilization [GO:0050821]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20873783}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000269|PubMed:20873783}.


uniprotID: P0CW21
geneSymbol: SPART-AS1
sequence: MKDIGHLQHLAQRLQWNRRAVNICGMHGWTKDLSPHSRMPSMLEHVKHYMSC
length: 52
name:
Putative uncharacterized protein SPART-AS1 (SPART antisense RNA 1) (SPG20 antisense RNA 1) (SPG20 opposite strand transcript protein)


uniprotID: Q96I25
geneSymbol: RBM17
reactome: R-HSA-72163;
pdb: 2PE8;2PEH;5LSO;
name: Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17)
length: 401
go: ENSG00000134453;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9731529}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; alternative mRNA splicing, via spliceosome [GO:0000380]; DNA repair [GO:0006281]; mRNA splicing, via spliceosome [GO:0000398]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]


uniprotID: Q6Q759
geneSymbol: SPAG17
name: Sperm-associated antigen 17 (Projection protein PF6 homolog)
length: 2223
go: ENSG00000155761;
snps: rs12133381 rs17185492 rs34366834 rs10923472
sequence:

opentargets:
axonemal central apparatus [GO:1990716]; microtubule [GO:0005874]; motile cilium [GO:0031514]; axonemal central apparatus assembly [GO:1904158]; epithelial cilium movement [GO:0003351]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5S003}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5S003}. Note=Detected in the cytoplasm of round spermatids and in condensing spermatids. Localized to the central pair of the sperm flagellar axoneme. Colocalizes with SPAG6 on microtubules (By similarity). {ECO:0000250|UniProtKB:Q5S003}.


uniprotID: O75830
geneSymbol: SERPINI2
length: 405
go: ENSG00000114204;
snps: rs17246389 rs9841174
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Serpin I2 (Myoepithelium-derived serine protease inhibitor) (Pancpin) (Pancreas-specific protein TSA2004) (Peptidase inhibitor 14) (PI-14)

sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]


uniprotID: Q96PI1
geneSymbol: SPRR4
name: Small proline-rich protein 4
sequence: MSSQQQQRQQQQCPPQRAQQQQVKQPCQPPPVKCQETCAPKTKDPCAPQVKKQCPPKGTIIPAQQKCPSAQQASKSKQK
length: 79
go: ENSG00000184148;
snps: rs16834786
opentargets:
cell cortex [GO:0005938]; cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; structural molecule activity [GO:0005198]; keratinization [GO:0031424]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes.


uniprotID: P35325
geneSymbol: SPRR2B
reactome: R-HSA-6809371;
name: Small proline-rich protein 2B (SPR-2B)
sequence: MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKYPPVTPSPPCQPKYPPKSK
length: 72
go: ENSG00000196805;
snps: rs1048268
location: SUBCELLULAR LOCATION: Cytoplasm.
opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; structural molecule activity [GO:0005198]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]


uniprotID: O00267
geneSymbol: SUPT5H
pdb: 2DO3;2E6Z;2E70;3H7H;4L1U;5OHO;5OHQ;5OIK;5U98;6GMH;6GML;
length: 1087
go: ENSG00000196235;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10075709}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-674695;R-HSA-6796648;R-HSA-6807505;R-HSA-72086;R-HSA-75955;R-HSA-77075;

name:
Transcription elongation factor SPT5 (hSPT5) (DRB sensitivity-inducing factor 160 kDa subunit) (DSIF p160) (DRB sensitivity-inducing factor large subunit) (DSIF large subunit) (Tat-cotransactivator 1 protein) (Tat-CT1 protein)

sequence:

opentargets:
DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; enzyme binding [GO:0019899]; mRNA binding [GO:0003729]; protein heterodimerization activity [GO:0046982]; RNA binding [GO:0003723]; 7-methylguanosine mRNA capping [GO:0006370]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of mRNA polyadenylation [GO:1900364]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of macroautophagy [GO:0016239]; positive regulation of transcription by RNA polymerase II [GO:0045944]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00267-1; Sequence=Displayed; Name=2; IsoId=O00267-2; Sequence=VSP_016282; 


uniprotID: Q5MJ08
geneSymbol: SPANXN4
sequence: MEEPTSSTNENKMKSPCESNKRKVDKKKKNLHRASAPEQSLKETEKAKYPTLVFYCRKNKKRNSNQLENNQPTESSTDPIKEKGDLDISAGSPQDGGQN
length: 99
go: ENSG00000189326;
snps: rs10482390
name:
Sperm protein associated with the nucleus on the X chromosome N4 (Nuclear-associated protein SPAN-Xn4) (SPANX-N4) (SPANX family member N4)


uniprotID: Q5T0L3
geneSymbol: SPATA46
name: Spermatogenesis-associated protein 46
length: 261
go: ENSG00000171722;
snps: rs164181 rs17853130
sequence:

opentargets:
nuclear membrane [GO:0031965]; cell differentiation [GO:0030154]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q4FZF2}. Note=Located throughout the subacrosomal area. {ECO:0000250|UniProtKB:Q4FZF2}.


uniprotID: Q9C004
geneSymbol: SPRY4
pdb: 3BUN;
name: Protein sprouty homolog 4 (Spry-4)
length: 299
go: ENSG00000187678;
snps: rs774674946 rs568363732 rs78310959 rs148983803 rs139512218 rs200364529 rs142439525
sequence:

opentargets:
cytosol [GO:0005829]; focal adhesion [GO:0005925]; ruffle membrane [GO:0032587]; multicellular organism development [GO:0007275]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of Ras protein signal transduction [GO:0046580]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=A; Synonyms=Sprouty-4A; IsoId=Q9C004-1; Sequence=Displayed; Name=C; Synonyms=Sprouty-4C; IsoId=Q9C004-2; Sequence=VSP_006219, VSP_006220; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12027893}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.


uniprotID: Q13813
geneSymbol: SPTAN1
reactome: R-HSA-264870;R-HSA-373753;R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6798695;R-HSA-6807878;
pdb: 2FOT;3F31;3FB2;5FW9;5FWB;5FWC;
length: 2472
go: ENSG00000197694;
snps: rs2227863 rs1048236
name:
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; specific granule lumen [GO:0035580]; spectrin [GO:0008091]; tertiary granule lumen [GO:1904724]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; calcium ion binding [GO:0005509]; calmodulin binding [GO:0005516]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; structural constituent of cytoskeleton [GO:0005200]; actin filament capping [GO:0051693]; axon guidance [GO:0007411]; ER to Golgi vesicle-mediated transport [GO:0006888]; MAPK cascade [GO:0000165]; neutrophil degranulation [GO:0043312]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13813-1; Sequence=Displayed; Name=2; IsoId=Q13813-2; Sequence=VSP_012270; Name=3; IsoId=Q13813-3; Sequence=VSP_012271; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Note=Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells. {ECO:0000250}.


uniprotID: Q15572
geneSymbol: TAF1C
reactome: R-HSA-427359;R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 869
go: ENSG00000103168;
location: SUBCELLULAR LOCATION: Nucleus.
name:
TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C)

sequence:

opentargets:
fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I CORE element sequence-specific DNA binding [GO:0001164]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of transcription by RNA polymerase I [GO:0006356]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase I promoter [GO:0006361]

snps:
rs4782591 rs4150145 rs4150147 rs4150151 rs4150165 rs4150167 rs4150170 rs2230129 rs4150172 rs4150173 rs4150175 rs2230131 rs3743640 rs4150176 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q15572-1; Sequence=Displayed; Name=2; IsoId=Q15572-2; Sequence=VSP_015153, VSP_015154, VSP_015156; Note=No experimental confirmation available.; Name=4; IsoId=Q15572-4; Sequence=VSP_038087; Note=No experimental confirmation available.; Name=5; IsoId=Q15572-5; Sequence=VSP_038086; Note=No experimental confirmation available.; Name=6; IsoId=Q15572-6; Sequence=VSP_015154; Note=No experimental confirmation available.; 


uniprotID: Q4G0T1
name: Scavenger receptor cysteine-rich domain-containing protein SCART1
length: 1027
go: ENSG00000214279;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
brush border [GO:0005903]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; integral component of membrane [GO:0016021]; scavenger receptor activity [GO:0005044]; T cell mediated immunity [GO:0002456]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q4G0T1-1; Sequence=Displayed; Note=Gene prediction based on EST data.; Name=Gamma; IsoId=Q4G0T1-2; Sequence=VSP_039839, VSP_039840; Name=Alpha; IsoId=Q4G0T1-3; Sequence=VSP_053841, VSP_053842; 


uniprotID: A7MD48
geneSymbol: SRRM4
length: 611
go: ENSG00000139767;
snps: rs7297606 rs2723880 rs2555273
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BKA3}.
name:
Serine/arginine repetitive matrix protein 4 (Medulloblastoma antigen MU-MB-2.76) (Neural-specific serine/arginine repetitive splicing factor of 100 kDa) (Neural-specific SR-related protein of 100 kDa) (nSR100)

sequence:

opentargets:
nucleus [GO:0005634]; mRNA binding [GO:0003729]; cell differentiation [GO:0030154]; mRNA processing [GO:0006397]; nervous system development [GO:0007399]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; regulation of RNA splicing [GO:0043484]; RNA splicing [GO:0008380]; sensory perception of sound [GO:0007605]


uniprotID: P78362
geneSymbol: SRPK2
pdb: 2X7G;5MYV;
length: 688
go: ENSG00000135250;
drug: DB00173;DB04395;DB02733;
snps: rs34699980 rs55743527 rs56112661 rs56017595 rs1050413 rs1050418
name:
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 14-3-3 protein binding [GO:0071889]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; innate immune response [GO:0045087]; intracellular signal transduction [GO:0035556]; negative regulation of viral genome replication [GO:0045071]; nuclear speck organization [GO:0035063]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of gene expression [GO:0010468]; regulation of mRNA processing [GO:0050684]; regulation of mRNA splicing, via spliceosome [GO:0048024]; RNA splicing [GO:0008380]; spliceosomal complex assembly [GO:0000245]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P78362-1; Sequence=Displayed; Name=2; IsoId=P78362-2; Sequence=VSP_039386; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. KAT5/TIP60 inhibits its nuclear translocation. Phosphorylation at Thr-492 by PKB/AKT1 promotes nuclear translocation.


uniprotID: Q9BRL6
geneSymbol: SRSF8
pdb: 2DNM;
length: 282
go: ENSG00000263465;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9671500}.
name:
Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA cis splicing, via spliceosome [GO:0045292]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BRL6-1; Sequence=Displayed; Name=2; IsoId=Q9BRL6-2; Sequence=VSP_028026; Note=No experimental confirmation available.; 


uniprotID: Q9NP77
geneSymbol: SSU72
reactome: R-HSA-6807505;
pdb: 3O2Q;3O2S;4H3H;4H3K;
length: 194
go: ENSG00000160075;
location: SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Predominantly in the cytosol.
name:
RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (CTD phosphatase SSU72) (EC 3.1.3.16)

sequence:
MPSSPLRVAVVCSSNQNRSMEAHNILSKRGFSVRSFGTGTHVKLPGPAPDKPNVYDFKTTYDQMYNDLLRKDKELYTQNGILHMLDRNKRIKPRPERFQNCKDLFDLILTCEERVYDQVVEDLNSREQETCQPVHVVNVDIQDNHEEATLGAFLICELCQCIQHTEDMENEIDELLQEFEEKSGRTFLHTVCFY

opentargets:
cytosol [GO:0005829]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; RNA polymerase II CTD heptapeptide repeat phosphatase activity [GO:0008420]; dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; mRNA polyadenylation [GO:0006378]; termination of RNA polymerase II transcription [GO:0006369]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NP77-1; Sequence=Displayed; Name=2; IsoId=Q9NP77-2; Sequence=VSP_033005; 


uniprotID: Q9Y5Y6
geneSymbol: ST14
reactome: R-HSA-6809371;
length: 855
go: ENSG00000149418;
drug: DB03127;DB00013;
snps: rs7126904 rs17667603 rs137852931
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
pdb:
1EAW;1EAX;2FMV;2GV6;2GV7;3BN9;3NCL;3NPS;3P8F;3P8G;3SO3;4IS5;4ISL;4ISN;4ISO;4JYT;4JZ1;4JZI;4O97;4O9V;4R0I;5LYO;

name:
Suppressor of tumorigenicity 14 protein (EC 3.4.21.109) (Matriptase) (Membrane-type serine protease 1) (MT-SP1) (Prostamin) (Serine protease 14) (Serine protease TADG-15) (Tumor-associated differentially-expressed gene 15 protein)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; cornification [GO:0070268]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; keratinocyte differentiation [GO:0030216]; neural tube closure [GO:0001843]; proteolysis [GO:0006508]


uniprotID: Q16385
geneSymbol: SSX2; SSX2B
length: 188
go: ENSG00000241476;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Protein SSX2 (Cancer/testis antigen 5.2) (CT5.2) (Synovial sarcoma, X breakpoint 2) (Tumor antigen HOM-MEL-40)

sequence:
MNGDDAFARRPTVGAQIPEKIQKAFDDIAKYFSKEEWEKMKASEKIFYVYMKRKYEAMTKLGFKATLPPFMCNKRAEDFQGNDLDNDPNRGNQVERPQMTFGRLQGISPKIMPKKPAEEGNDSEEVPEASGPQNDGKELCPPGKPTTSEKIHERSGPKRGEHAWTHRLRERKQLVIYEEISDPEEDDE

opentargets:
nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q16385-1; Sequence=Displayed; Name=2; IsoId=Q16385-2; Sequence=VSP_017595; Note=No experimental confirmation available.; 


uniprotID: Q9Y3M8
geneSymbol: STARD13
reactome: R-HSA-194840;
pdb: 2H80;2JW2;2PSO;
length: 1113
go: ENSG00000133121;
snps: rs9568878 rs3742321 rs34425674 rs35144435
name:
StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)

sequence:

opentargets:
cytosol [GO:0005829]; lipid droplet [GO:0005811]; mitochondrial membrane [GO:0031966]; GTPase activator activity [GO:0005096]; lipid binding [GO:0008289]; endothelial cell migration [GO:0043542]; endothelial tube lumen extension [GO:0097498]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=DLC2alpha; IsoId=Q9Y3M8-1; Sequence=Displayed; Name=2; Synonyms=DLC2beta; IsoId=Q9Y3M8-2; Sequence=VSP_017354; Name=3; Synonyms=DLC2gamma; IsoId=Q9Y3M8-3; Sequence=VSP_017353; Name=4; IsoId=Q9Y3M8-4; Sequence=VSP_017355; Name=5; IsoId=Q9Y3M8-5; Sequence=VSP_017354, VSP_017356, VSP_017357; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.


uniprotID: O60284
geneSymbol: ST18
pdb: 2CS8;
name: Suppression of tumorigenicity 18 protein (Zinc finger protein 387)
length: 1047
go: ENSG00000147488;
snps: rs2303460
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15489893}.
sequence:

opentargets:
nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; zinc ion binding [GO:0008270]; interleukin-1-mediated signaling pathway [GO:0070498]; interleukin-6-mediated signaling pathway [GO:0070102]; negative regulation of cell proliferation [GO:0008285]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of transcription by RNA polymerase II [GO:0045944]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: Q15532
geneSymbol: SS18
name: Protein SSXT (Protein SYT) (Synovial sarcoma translocated to X chromosome protein)
length: 418
go: ENSG00000141380;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
cytoplasmic microtubule [GO:0005881]; npBAF complex [GO:0071564]; nucleus [GO:0005634]; SWI/SNF complex [GO:0016514]; nuclear receptor transcription coactivator activity [GO:0030374]; cell morphogenesis [GO:0000902]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; microtubule cytoskeleton organization [GO:0000226]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; response to drug [GO:0042493]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=SYTins, SYT-L; IsoId=Q15532-1; Sequence=Displayed; Name=2; IsoId=Q15532-2; Sequence=VSP_006258; 


uniprotID: Q8IUX1
geneSymbol: TMEM126B
reactome: R-HSA-6799198;
name: Complex I assembly factor TMEM126B, mitochondrial (Transmembrane protein 126B)
length: 230
go: ENSG00000171204;
snps: rs17850847
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; mitochondrial respiratory chain complex I assembly [GO:0032981]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8IUX1-1; Sequence=Displayed; Name=2; IsoId=Q8IUX1-2; Sequence=VSP_023871, VSP_023872; Note=No experimental confirmation available.; Name=3; IsoId=Q8IUX1-3; Sequence=VSP_023870, VSP_023873, VSP_023874; Note=No experimental confirmation available.; Name=4; IsoId=Q8IUX1-4; Sequence=VSP_023875; Note=No experimental confirmation available.; Name=5; IsoId=Q8IUX1-5; Sequence=VSP_023870; 

location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:24191001}; Multi-pass membrane protein {ECO:0000269|PubMed:24191001}.


uniprotID: Q8N5J4
geneSymbol: SPIC
name: Transcription factor Spi-C
length: 248
go: ENSG00000166211;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; blastocyst development [GO:0001824]; cell differentiation [GO:0030154]; regulation of transcription by RNA polymerase II [GO:0006357]


uniprotID: Q9HCB6
geneSymbol: SPON1
reactome: R-HSA-5083635;R-HSA-5173214;
pdb: 2ZOT;2ZOU;3COO;3Q13;
name: Spondin-1 (F-spondin) (Vascular smooth muscle cell growth-promoting factor)
length: 807
go: ENSG00000262655;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; LBD domain binding [GO:0050693]; metal ion binding [GO:0046872]; cell adhesion [GO:0007155]; negative regulation of amyloid-beta formation [GO:1902430]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of protein binding [GO:0032092]; positive regulation of protein processing [GO:0010954]


uniprotID: Q9NS25
geneSymbol: SPANXB1
length: 103
go: ENSG00000227234;
opentargets: cytoplasm [GO:0005737]; nucleus [GO:0005634]; spermatid development [GO:0007286]
snps: rs878856926
name:
Sperm protein associated with the nucleus on the X chromosome B1 (Cancer/testis antigen 11.2) (CT11.2) (Nuclear-associated protein SPAN-Xb) (SPANX-B) (SPANX family member B1) (SPANX family member F1)

sequence:
MGQQSSVRRLKRSVPCESNEANEANEANKTMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNVKRTSPEELLNDHARENRINPDQMEEEEFIEITTERPKK

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.


uniprotID: Q9NZD8
geneSymbol: SPG21
length: 308
go: ENSG00000090487;
name:
Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)

sequence:

opentargets:
cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; trans-Golgi network transport vesicle [GO:0030140]; CD4 receptor binding [GO:0042609]; antigen receptor-mediated signaling pathway [GO:0050851]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NZD8-1; Sequence=Displayed; Name=2; IsoId=Q9NZD8-2; Sequence=VSP_041512; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11113139}. Membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Endosome membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11113139}; Peripheral membrane protein {ECO:0000269|PubMed:11113139}. Note=Partially localized in the cytosol but also accumulated on an intracellular vesicular compartment. Colocalizes with CD4 on endosomal/trans-Golgi network.


uniprotID: Q6UW49
geneSymbol: SPESP1
length: 350
go: ENSG00000258484;
snps: rs3743091 rs16952684 rs3743093
name:
Sperm equatorial segment protein 1 (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; acrosome reaction [GO:0007340]; fertilization [GO:0009566]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; multicellular organism development [GO:0007275]; sperm-egg recognition [GO:0035036]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12773409}. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity). {ECO:0000250|UniProtKB:Q9D5A0, ECO:0000269|PubMed:12773409}.


uniprotID: Q2M3C7
geneSymbol: SPHKAP
length: 1700
go: ENSG00000153820;
snps: rs4283414 rs3811514 rs3811515 rs3828161 rs16824283
name:
A-kinase anchor protein SPHKAP (SPHK1-interactor and AKAP domain-containing protein) (Sphingosine kinase type 1-interacting protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; protein kinase A binding [GO:0051018]; regulation of protein kinase A signaling [GO:0010738]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2M3C7-1; Sequence=Displayed; Name=2; IsoId=Q2M3C7-2; Sequence=VSP_031712; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12080051, ECO:0000269|PubMed:20394097}. Note=Colocalizes with SPHK1 in the cytoplasm.


uniprotID: P22528
geneSymbol: SPRR1B
reactome: R-HSA-6809371;
name: Cornifin-B (14.9 kDa pancornulin) (Small proline-rich protein IB) (SPR-IB)
sequence: MSSQQQKQPCTPPPQLQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCHPKVPEPCPSIVTPAPAQQKTKQK
length: 89
go: ENSG00000169469;
snps: rs3795382 rs768218193
location: SUBCELLULAR LOCATION: Cytoplasm.
opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein binding, bridging [GO:0030674]; structural molecule activity [GO:0005198]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]


uniprotID: Q5MJ10
geneSymbol: SPANXN2
length: 180
go: ENSG00000268988;
snps: rs79543398
name:
Sperm protein associated with the nucleus on the X chromosome N2 (Nuclear-associated protein SPAN-Xn2) (SPANX-N2) (SPANX family member N2)

sequence:
MEQPTSSTNGEKRKSPCESNNKKNDEMQEAPNRVLAPKQSLQKTKTIEYLTIIVYYYRKHTKINSNQLEKDQSRENSINPVQEEEDEGLDSAEGSSQEDEDLDSSEGSSQEDEDLDSSEGSSQEDEDLDSSEGSSQEDEDLDSSEGSSQEDEDLDPPEGSSQEDEDLDSSEGSSQEGGED


uniprotID: P22531
geneSymbol: SPRR2E
reactome: R-HSA-6809371;
name: Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II)
sequence: MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPCPPPKCPQPCPPQQCQQKCPPVTPSPPCQPKCPPKSK
length: 72
go: ENSG00000203785;
location: SUBCELLULAR LOCATION: Cytoplasm.
opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; structural constituent of epidermis [GO:0030280]; structural molecule activity [GO:0005198]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]


uniprotID: P11277
geneSymbol: SPTB
reactome: R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6807878;
pdb: 1S35;3EDU;3F57;3KBT;3KBU;3LBX;
name: Spectrin beta chain, erythrocytic (Beta-I spectrin)
length: 2137
go: ENSG00000070182;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cell surface [GO:0009986]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; protein-containing complex [GO:0032991]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; ankyrin binding [GO:0030506]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; structural constituent of cytoskeleton [GO:0005200]; actin filament capping [GO:0051693]; axon guidance [GO:0007411]; ER to Golgi vesicle-mediated transport [GO:0006888]; MAPK cascade [GO:0000165]

snps:
rs121918646 rs229587 rs55752508 rs3742601 rs77806 rs10132778 rs17180350 rs17245552 rs121918647 rs121918648 rs367841692 rs1225539653 rs121918649 rs121918645 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P11277-1; Sequence=Displayed; Name=2; Synonyms=Muscle-specific; IsoId=P11277-2; Sequence=VSP_000719; Name=3; IsoId=P11277-3; Sequence=VSP_007242; Note=Due to exon skipping.; 


uniprotID: P21549
geneSymbol: AGXT
reactome: R-HSA-389661;R-HSA-9033241;
pdb: 1H0C;1J04;2YOB;3R9A;4CBR;4CBS;4I8A;4KXK;4KYO;5F9S;5HHY;5LUC;5OFY;5OG0;
length: 392
go: ENSG00000172482;
drug: DB08060;DB02079;DB00145;DB00160;DB00133;DB04083;DB00114;
name:
Serine--pyruvate aminotransferase (SPT) (EC 2.6.1.51) (Alanine--glyoxylate aminotransferase) (AGT) (EC 2.6.1.44)

sequence:

opentargets:
cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrial matrix [GO:0005759]; peroxisomal matrix [GO:0005782]; peroxisome [GO:0005777]; alanine-glyoxylate transaminase activity [GO:0008453]; amino acid binding [GO:0016597]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; protein self-association [GO:0043621]; pyridoxal phosphate binding [GO:0030170]; serine-pyruvate transaminase activity [GO:0004760]; signaling receptor binding [GO:0005102]; transaminase activity [GO:0008483]; cellular nitrogen compound metabolic process [GO:0034641]; glycine biosynthetic process, by transamination of glyoxylate [GO:0019265]; glyoxylate catabolic process [GO:0009436]; glyoxylate metabolic process [GO:0046487]; L-alanine catabolic process [GO:0042853]; L-cysteine catabolic process [GO:0019448]; Notch signaling pathway [GO:0007219]; oxalic acid secretion [GO:0046724]; protein targeting to peroxisome [GO:0006625]; pyruvate biosynthetic process [GO:0042866]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]

snps:
rs115014558 rs34116584 rs34885252 rs180177157 rs180177168 rs121908523 rs180177168 rs180177173 rs121908522 rs180177185 rs180177197 rs796052061 rs180177207 rs180177222 rs121908524 rs180177223 rs121908530 rs180177225 rs180177227 rs180177227 rs180177227 rs180177230 rs121908529 rs180177231 rs180177236 rs180177238 rs180177239 rs180177244 rs180177246 rs536352238 rs121908520 rs180177253 rs121908526 rs121908527 rs121908527 rs180177258 rs121908525 rs180177264 rs180177277 rs140992177 rs73106685 rs180177289 rs180177290 rs13408961 rs180177293 rs115057148 rs180177155 rs4426527 rs180177156 

location:
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:1703535, ECO:0000269|PubMed:23229545, ECO:0000269|PubMed:24055001, ECO:0000269|PubMed:26149463}. Mitochondrion {ECO:0000269|PubMed:1703535, ECO:0000269|PubMed:23229545}. Note=Predominantly localized in the peroxisomes. Mitochondrial mistargeting occurs in variant proteins Arg-41, Arg-47, Ile-152, Arg-170 and Thr-244 associated with the disease HP1. {ECO:0000269|PubMed:23229545}.


uniprotID: O76094
geneSymbol: SRP72
reactome: R-HSA-1799339;
pdb: 5M72;5M73;5WRV;5WRW;
name: Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein)
length: 671
go: ENSG00000174780;
snps: rs387907189
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; TPR domain binding [GO:0030911]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O76094-1; Sequence=Displayed; Name=2; IsoId=O76094-2; Sequence=VSP_045576; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22541560}. Endoplasmic reticulum {ECO:0000269|PubMed:22541560}.


uniprotID: A2VEC9
geneSymbol: SSPO
reactome: R-HSA-5083635;R-HSA-5173214;
name: SCO-spondin
length: 5150
go: ENSG00000197558;
location: SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
sequence:

opentargets:
extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; nervous system development [GO:0007399]

snps:
rs709061 rs17754559 rs855677 rs199648588 rs709060 rs709060 rs855691 rs855692 rs2074704 rs893601 rs1635802 rs1076277 rs4725314 rs2074689 rs59522380 rs181269877 rs10260959 rs740109 rs10952230 rs1557955 rs745044 rs1005603 rs12536873 rs10233245 rs1008336 rs1004200 rs12534509 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A2VEC9-1; Sequence=Displayed; Name=2; IsoId=A2VEC9-2; Sequence=VSP_035258, VSP_035259, VSP_035260, VSP_035261, VSP_035262, VSP_035263; Note=No experimental confirmation available.; 


uniprotID: P48595
geneSymbol: SERPINB10
reactome: R-HSA-6798695;
name: Serpin B10 (Bomapin) (Peptidase inhibitor 10) (PI-10)
length: 397
go: ENSG00000242550;
snps: rs17072097 rs8097425 rs724558 rs17072146 rs9967382 rs963075 rs35453062
location: SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mostly found in the nucleus.
sequence:

opentargets:
extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]; neutrophil degranulation [GO:0043312]


uniprotID: Q8NFV5
geneSymbol: SPDYE1
name: Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)
length: 336
opentargets: protein kinase binding [GO:0019901]
sequence:


uniprotID: A6NIY4
geneSymbol: SPDYE5
name: Speedy protein E5
length: 402
go: ENSG00000170092;
opentargets: protein kinase binding [GO:0019901]
sequence:


uniprotID: Q96P63
geneSymbol: SERPINB12
reactome: R-HSA-6798695;
name: Serpin B12
length: 405
go: ENSG00000166634;
snps: rs35582068 rs35352345 rs11664907
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; enzyme binding [GO:0019899]; serine-type endopeptidase inhibitor activity [GO:0004867]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of protein catabolic process [GO:0042177]; neutrophil degranulation [GO:0043312]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96P63-1; Sequence=Displayed; Name=2; IsoId=Q96P63-2; Sequence=VSP_056279; Note=No experimental confirmation available.; 


uniprotID: Q14DG7
geneSymbol: TMEM132B
name: Transmembrane protein 132B
length: 1078
go: ENSG00000139364;
opentargets: integral component of membrane [GO:0016021]
snps: rs16919359
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q14DG7-1; Sequence=Displayed; Name=2; IsoId=Q14DG7-2; Sequence=VSP_024577, VSP_024578; Note=No experimental confirmation available.; Name=3; IsoId=Q14DG7-3; Sequence=VSP_024576; 


uniprotID: O75635
geneSymbol: SERPINB7
name: Serpin B7 (Megsin) (TP55)
length: 380
go: ENSG00000166396;
snps: rs17782413
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of glomerular mesangial cell proliferation [GO:0072126]; positive regulation of platelet-derived growth factor production [GO:0090362]; positive regulation of transforming growth factor beta1 production [GO:0032914]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75635-1; Sequence=Displayed; Name=2; IsoId=O75635-2; Sequence=VSP_044711; Note=No experimental confirmation available.; 


uniprotID: Q9H0A9
geneSymbol: SPATC1L
name: Speriolin-like protein (Spermatogenesis and centriole-associated protein 1-like protein)
length: 340
go: ENSG00000160284;
opentargets: centrosome [GO:0005813]
snps: rs884134 rs14378
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H0A9-1; Sequence=Displayed; Name=2; IsoId=Q9H0A9-2; Sequence=VSP_039151; 


uniprotID: Q86U17
geneSymbol: SERPINA11
name: Serpin A11
length: 422
go: ENSG00000186910;
snps: rs1885137 rs17752285
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]


uniprotID: Q8IW75
geneSymbol: SERPINA12
pdb: 4IF8;4Y3K;4Y40;5EI0;
length: 414
go: ENSG00000165953;
snps: rs17090972 rs192558870 rs34519784
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:28668641}.
name:
Serpin A12 (OL-64) (Visceral adipose tissue-derived serine protease inhibitor) (Vaspin) (Visceral adipose-specific serpin)

sequence:

opentargets:
extracellular space [GO:0005615]; plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of gluconeogenesis [GO:0045721]; negative regulation of lipid biosynthetic process [GO:0051055]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; regulation of cholesterol metabolic process [GO:0090181]; regulation of triglyceride metabolic process [GO:0090207]


uniprotID: Q6UXR4
geneSymbol: SERPINA13P
name: Putative serpin A13
length: 307
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]


uniprotID: Q8IUW3
geneSymbol: SPATA2L
name: Spermatogenesis-associated protein 2-like protein (SPATA2-like protein)
length: 424
go: ENSG00000158792;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IUW3-1; Sequence=Displayed; Name=2; IsoId=Q8IUW3-2; Sequence=VSP_027332, VSP_027333; Note=No experimental confirmation available.; 


uniprotID: P49223
geneSymbol: SPINT3
name: Kunitz-type protease inhibitor 3 (HKIB9)
sequence: MQLQASLSFLLILTLCLELRSELARDTIKDLLPNVCAFPMEKGPCQTYMTRWFFNFETGECELFAYGGCGGNSNNFLRKEKCEKFCKFT
length: 89
go: ENSG00000101446;
snps: rs6032259
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
opentargets:
extracellular region [GO:0005576]; receptor antagonist activity [GO:0048019]; serine-type endopeptidase inhibitor activity [GO:0004867]; transforming growth factor beta binding [GO:0050431]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]


uniprotID: Q76KD6
geneSymbol: SPATC1
length: 591
go: ENSG00000186583;
opentargets: centrosome [GO:0005813]; cytoplasm [GO:0005737]
name:
Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q76KD6-1; Sequence=Displayed; Name=2; IsoId=Q76KD6-2; Sequence=VSP_042815, VSP_042816; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with the centrosomal pericentrin protein PCNT1 (By similarity). Located in the connecting piece of sperm. {ECO:0000250, ECO:0000269|PubMed:20542897}.


uniprotID: A0A1B0GTR4
geneSymbol: SPRR5
name: Putative small proline-rich protein 5
length: 108
sequence:
MSQQKQKQCAPPQQCCPPPQQRCPPPQQCCPPPQQCCPPPQQCCPPPQQCCPPPQQCCPPPQQCCPPPQQYCPPPQQTKQPCQPPPKCQEPCAPKCPPPQQCQTSKQK


uniprotID: Q9H040
geneSymbol: SPRTN
reactome: R-HSA-110320;
pdb: 5IY4;
length: 489
go: ENSG00000010072;
snps: rs527236213 rs2437150
name:
SprT-like domain-containing protein Spartan (DNA damage protein targeting VCP) (DVC1) (Protein with SprT-like domain at the N terminus) (Spartan)

sequence:

opentargets:
chromosome [GO:0005694]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; ubiquitin binding [GO:0043130]; cellular response to DNA damage stimulus [GO:0006974]; error-free translesion synthesis [GO:0070987]; positive regulation of protein ubiquitination [GO:0031398]; response to UV [GO:0009411]; translesion synthesis [GO:0019985]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H040-1; Sequence=Displayed; Name=2; IsoId=Q9H040-2; Sequence=VSP_029891, VSP_029892; Note=No experimental confirmation available.; Name=3; IsoId=Q9H040-3; Sequence=VSP_046925, VSP_029891, VSP_029892; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled replication forks at sites of replication stress.


uniprotID: O43609
geneSymbol: SPRY1
reactome: R-HSA-182971;
name: Protein sprouty homolog 1 (Spry-1)
length: 319
go: ENSG00000164056;
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; bud elongation involved in lung branching [GO:0060449]; epithelial to mesenchymal transition involved in cardiac fibroblast development [GO:0060940]; establishment of mitotic spindle orientation [GO:0000132]; metanephros development [GO:0001656]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of Ras protein signal transduction [GO:0046580]; organ induction [GO:0001759]; ureteric bud development [GO:0001657]

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).


uniprotID: Q16514
geneSymbol: TAF12
pdb: 1H3O;
length: 161
go: ENSG00000120656;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-3214847;R-HSA-674695;R-HSA-6804756;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15)

sequence:
MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTKKKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHLERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCAF complex [GO:0000125]; SAGA complex [GO:0000124]; SLIK (SAGA-like) complex [GO:0046695]; STAGA complex [GO:0030914]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; RNA polymerase II activating transcription factor binding [GO:0001102]; TBP-class protein binding [GO:0017025]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; DNA-templated transcription, initiation [GO:0006352]; histone H3 acetylation [GO:0043966]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=TAFII20; IsoId=Q16514-1; Sequence=Displayed; Name=TAFII15; IsoId=Q16514-2; Sequence=VSP_018888; 


uniprotID: O15042
geneSymbol: U2SURP
reactome: R-HSA-72163;
length: 1029
go: ENSG00000163714;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735}.
name:
U2 snRNP-associated SURP motif-containing protein (140 kDa Ser/Arg-rich domain protein) (U2-associated protein SR140)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O15042-1; Sequence=Displayed; Name=2; IsoId=O15042-2; Sequence=VSP_023523; Name=3; IsoId=O15042-3; Sequence=VSP_023522, VSP_023524; 


uniprotID: P63272
geneSymbol: SUPT4H1
pdb: 3H7H;5OIK;6GMH;6GML;
length: 117
go: ENSG00000213246;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8649394}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-674695;R-HSA-6796648;R-HSA-6807505;R-HSA-75955;

name:
Transcription elongation factor SPT4 (hSPT4) (DRB sensitivity-inducing factor 14 kDa subunit) (DSIF p14) (DRB sensitivity-inducing factor small subunit) (DSIF small subunit)

sequence:
MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT

opentargets:
DSIF complex [GO:0032044]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; protein heterodimerization activity [GO:0046982]; RNA polymerase II complex binding [GO:0000993]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; chromatin remodeling [GO:0006338]; negative regulation of DNA-templated transcription, elongation [GO:0032785]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of DNA-templated transcription, elongation [GO:0032786]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]


uniprotID: Q96L03
geneSymbol: SPATA17
name: Spermatogenesis-associated protein 17
length: 361
go: ENSG00000162814;
opentargets: cytoplasm [GO:0005737]; calmodulin binding [GO:0005516]
snps: rs34652544
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:


uniprotID: Q9BXG8
geneSymbol: SPZ1
length: 430
go: ENSG00000164299;
snps: rs1862136 rs6867419
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
name:
Spermatogenic leucine zipper protein 1 (Testis-specific protein 1) (Testis-specific protein NYD-TSP1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]


uniprotID: Q9H254
geneSymbol: SPTBN4
reactome: R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6807878;
name: Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)
length: 2564
go: ENSG00000160460;
snps: rs814501
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}.
sequence:

opentargets:
adherens junction [GO:0005912]; axon hillock [GO:0043203]; axon initial segment [GO:0043194]; cell body fiber [GO:0070852]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; intercalated disc [GO:0014704]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; node of Ranvier [GO:0033268]; nuclear matrix [GO:0016363]; paranode region of axon [GO:0033270]; plasma membrane [GO:0005886]; PML body [GO:0016605]; spectrin [GO:0008091]; actin binding [GO:0003779]; ankyrin binding [GO:0030506]; phosphatase binding [GO:0019902]; phospholipid binding [GO:0005543]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; spectrin binding [GO:0030507]; structural constituent of cytoskeleton [GO:0005200]; actin filament capping [GO:0051693]; adult walking behavior [GO:0007628]; axon guidance [GO:0007411]; axonogenesis [GO:0007409]; cardiac conduction [GO:0061337]; central nervous system projection neuron axonogenesis [GO:0021952]; clustering of voltage-gated sodium channels [GO:0045162]; cytoskeletal anchoring at plasma membrane [GO:0007016]; ER to Golgi vesicle-mediated transport [GO:0006888]; fertilization [GO:0009566]; MAPK cascade [GO:0000165]; negative regulation of heart rate [GO:0010459]; positive regulation of multicellular organism growth [GO:0040018]; protein localization to plasma membrane [GO:0072659]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of sodium ion transport [GO:0002028]; sensory perception of sound [GO:0007605]; transmission of nerve impulse [GO:0019226]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9H254-1; Sequence=Displayed; Name=2; IsoId=Q9H254-2; Sequence=VSP_000725, VSP_000726; Name=3; IsoId=Q9H254-3; Sequence=VSP_000723, VSP_000724; Name=4; IsoId=Q9H254-4; Sequence=VSP_000727, VSP_000728; Name=5; IsoId=Q9H254-5; Sequence=VSP_046383, VSP_046384, VSP_046385; 


uniprotID: Q8WW59
geneSymbol: SPRYD4
name: SPRY domain-containing protein 4
length: 207
opentargets: nucleus [GO:0005634]
snps: rs2657881
sequence:


uniprotID: Q9H2V7
geneSymbol: SPNS1
name: Protein spinster homolog 1 (HSpin1) (Spinster-like protein 1)
length: 528
go: ENSG00000169682;
snps: rs17855956
sequence:

opentargets:
integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; mitochondrial inner membrane [GO:0005743]; lipid transport [GO:0006869]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9H2V7-1; Sequence=Displayed; Name=2; IsoId=Q9H2V7-2; Sequence=VSP_028196; Name=3; Synonyms=CRA_d; IsoId=Q9H2V7-3; Sequence=VSP_028195, VSP_028196; Name=4; IsoId=Q9H2V7-4; Sequence=VSP_028194; Note=No experimental confirmation available.; Name=5; IsoId=Q9H2V7-5; Sequence=VSP_036389; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:12815463}; Multi-pass membrane protein {ECO:0000269|PubMed:12815463}. Note=Colocalizes with SDHB.


uniprotID: P02549
geneSymbol: SPTA1
reactome: R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6807878;
pdb: 1OWA;3LBX;5J4O;
name: Spectrin alpha chain, erythrocytic 1 (Erythroid alpha-spectrin)
length: 2419
go: ENSG00000163554;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cuticular plate [GO:0032437]; cytosol [GO:0005829]; intrinsic component of the cytoplasmic side of the plasma membrane [GO:0031235]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; protein heterodimerization activity [GO:0046982]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; structural constituent of cytoskeleton [GO:0005200]; actin filament capping [GO:0051693]; actin filament organization [GO:0007015]; axon guidance [GO:0007411]; ER to Golgi vesicle-mediated transport [GO:0006888]; hemopoiesis [GO:0030097]; lymphocyte homeostasis [GO:0002260]; MAPK cascade [GO:0000165]; plasma membrane organization [GO:0007009]; porphyrin-containing compound biosynthetic process [GO:0006779]; positive regulation of protein binding [GO:0032092]; positive regulation of T cell proliferation [GO:0042102]; regulation of cell shape [GO:0008360]

snps:
rs121918642 rs121918641 rs121918641 rs121918642 rs773826036 rs201568233 rs121918640 rs121918637 rs121918638 rs121918644 rs121918639 rs3737521 rs199725919 rs16840544 rs121918643 rs121918634 rs121918636 rs121918635 rs12090314 rs11265047 rs7418956 rs7547313 rs35121052 rs34706737 rs35948326 rs2482965 rs34214405 rs863931 rs857725 rs16830483 rs3737515 rs952094 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P02549-1; Sequence=Displayed; Name=2; IsoId=P02549-2; Sequence=VSP_037662; Note=Gene prediction based on EST data.; 


uniprotID: Q9BT56
geneSymbol: SPX
name: Spexin (NPQ) (Neuropeptide Q) (Spexin hormone) [Cleaved into: Spexin-1; Spexin-2 (NPQ 53-70)]
length: 116
go: ENSG00000134548;
sequence:
MKGLRSLAATTLALFLVFVFLGNSSCAPQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLSDRPLPERRSPNPQLLTIPEAATILLASLQKSPEDEEKNFDQTRFLEDSLLNW

opentargets:
cytoplasm [GO:0005737]; dense core granule [GO:0031045]; extracellular space [GO:0005615]; transport vesicle [GO:0030133]; neuropeptide hormone activity [GO:0005184]; type 2 galanin receptor binding [GO:0031765]; type 3 galanin receptor binding [GO:0031766]; long-chain fatty acid import [GO:0044539]; negative regulation of appetite [GO:0032099]; negative regulation of heart rate [GO:0010459]; negative regulation of renal sodium excretion [GO:0035814]; positive regulation of gastro-intestinal system smooth muscle contraction [GO:1904306]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of sensory perception of pain [GO:0051930]

location:
SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:19193193 and PubMed:17284679). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.


uniprotID: A4D263
geneSymbol: SPATA48
name: Spermatogenesis-associated protein 48
length: 438
go: ENSG00000164500;
sequence:


uniprotID: Q9BXB7
geneSymbol: SPATA16
name: Spermatogenesis-associated protein 16 (Testis development protein NYD-SP12)
length: 569
go: ENSG00000144962;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

snps:
rs16846624 rs1515441 rs11558933 rs1515442 rs16846616 rs137853118 rs373336427 rs115095786 rs62622782 rs952207260 

location:
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:12529416}. Note=Localized to the perinuclear region.


uniprotID: Q8WTU2
geneSymbol: SSC4D
length: 575
go: ENSG00000146700;
snps: rs4728712
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Scavenger receptor cysteine-rich domain-containing group B protein (Four scavenger receptor cysteine-rich domains-containing protein) (S4D-SRCRB)

sequence:

opentargets:
external side of plasma membrane [GO:0009897]; extracellular region [GO:0005576]; scavenger receptor activity [GO:0005044]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:12466895}; IsoId=Q8WTU2-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=Q8WTU2-2; Sequence=VSP_052695, VSP_052696; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}; 


uniprotID: Q15573
geneSymbol: TAF1A
reactome: R-HSA-427359;R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 450
go: ENSG00000143498;
snps: rs17163271
location: SUBCELLULAR LOCATION: Nucleus.
name:
TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A)

sequence:

opentargets:
microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; RNA polymerase I transcription factor complex [GO:0000120]; DNA binding [GO:0003677]; positive regulation of gene expression, epigenetic [GO:0045815]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase I promoter [GO:0006361]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15573-1; Sequence=Displayed; Name=2; IsoId=Q15573-2; Sequence=VSP_017635; Note=No experimental confirmation available.; 


uniprotID: Q14515
geneSymbol: SPARCL1
reactome: R-HSA-381426;R-HSA-8957275;
name: SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9)
length: 664
go: ENSG00000152583;
snps: rs13051 rs1049544 rs1130643
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]; signal transduction [GO:0007165]; synaptic membrane adhesion [GO:0099560]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14515-1; Sequence=Displayed; Name=2; IsoId=Q14515-2; Sequence=VSP_056678; Note=No experimental confirmation available.; 


uniprotID: O15020
geneSymbol: SPTBN2
reactome: R-HSA-2132295;R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6807878;
pdb: 1WJM;1WYQ;6ANU;
name: Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)
length: 2390
go: ENSG00000173898;
snps: rs121918306 rs397514749 rs4930388 rs36054877 rs506028
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cytosol [GO:0005829]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; neuronal cell body [GO:0043025]; parallel fiber to Purkinje cell synapse [GO:0098688]; postsynaptic spectrin-associated cytoskeleton [GO:0099189]; presynapse [GO:0098793]; spectrin [GO:0008091]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; phospholipid binding [GO:0005543]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of synapse [GO:0098918]; actin filament capping [GO:0051693]; adult behavior [GO:0030534]; antigen processing and presentation of exogenous peptide antigen via MHC class II [GO:0019886]; axon guidance [GO:0007411]; cerebellar Purkinje cell layer morphogenesis [GO:0021692]; ER to Golgi vesicle-mediated transport [GO:0006888]; MAPK cascade [GO:0000165]; multicellular organism growth [GO:0035264]; postsynapse organization [GO:0099173]; synapse assembly [GO:0007416]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15020-1; Sequence=Displayed; Name=2; IsoId=O15020-2; Sequence=VSP_000722; 


uniprotID: Q14247
geneSymbol: CTTN
reactome: R-HSA-5627123;R-HSA-8856828;
pdb: 1X69;2D1X;
name: Src substrate cortactin (Amplaxin) (Oncogene EMS1)
length: 550
go: ENSG00000085733;
sequence:

opentargets:
cell cortex [GO:0005938]; clathrin-coated pit [GO:0005905]; cortical cytoskeleton [GO:0030863]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; focal adhesion [GO:0005925]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; mitotic spindle midzone [GO:1990023]; plasma membrane [GO:0005886]; podosome [GO:0002102]; ruffle [GO:0001726]; voltage-gated potassium channel complex [GO:0008076]; cadherin binding [GO:0045296]; profilin binding [GO:0005522]; actin cytoskeleton reorganization [GO:0031532]; actin filament polymerization [GO:0030041]; cell motility [GO:0048870]; dendritic spine maintenance [GO:0097062]; focal adhesion assembly [GO:0048041]; intracellular protein transport [GO:0006886]; lamellipodium organization [GO:0097581]; membrane organization [GO:0061024]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; neuron projection morphogenesis [GO:0048812]; positive regulation of actin filament polymerization [GO:0030838]; positive regulation of smooth muscle contraction [GO:0045987]; receptor-mediated endocytosis [GO:0006898]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of axon extension [GO:0030516]; substrate-dependent cell migration, cell extension [GO:0006930]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q14247-1; Sequence=Displayed; Name=2; IsoId=Q14247-2; Sequence=VSP_043120, VSP_043121; Note=No experimental confirmation available.; Name=3; IsoId=Q14247-3; Sequence=VSP_043120; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12151401}. Cell projection, lamellipodium {ECO:0000269|PubMed:12151401}. Cell projection, ruffle. Cell projection, dendrite {ECO:0000250}. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000305|PubMed:17959782}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12151401}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers (By similarity). In the presence of CTTNBP2, localizes at the cell cortex (By similarity). In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft (By similarity). Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250|UniProtKB:Q60598, ECO:0000250|UniProtKB:Q66HL2}.


uniprotID: Q6ZRS2
geneSymbol: SRCAP
name: Helicase SRCAP (EC 3.6.4.-) (Domino homolog 2) (Snf2-related CBP activator)
length: 3230
go: ENSG00000080603;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00549, ECO:0000269|PubMed:10702287}.
sequence:

opentargets:
Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; Swr1 complex [GO:0000812]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; helicase activity [GO:0004386]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; transcription coactivator activity [GO:0003713]; ATP-dependent chromatin remodeling [GO:0043044]; chromatin remodeling [GO:0006338]; gene silencing [GO:0016458]; histone exchange [GO:0043486]; regulation of transcription by RNA polymerase II [GO:0006357]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZRS2-1; Sequence=Displayed; Name=2; IsoId=Q6ZRS2-2; Sequence=VSP_029442; Name=3; IsoId=Q6ZRS2-3; Sequence=VSP_029441, VSP_029442; 


uniprotID: Q15545
geneSymbol: TAF7
pdb: 4RGW;5FUR;
length: 349
go: ENSG00000178913;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9R1C0}.
name:
Transcription initiation factor TFIID subunit 7 (RNA polymerase II TBP-associated factor subunit F) (Transcription initiation factor TFIID 55 kDa subunit) (TAF(II)55) (TAFII-55) (TAFII55)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; transcription factor complex [GO:0005667]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; histone acetyltransferase binding [GO:0035035]; P-TEFb complex binding [GO:0106140]; protein heterodimerization activity [GO:0046982]; TFIIH-class transcription factor complex binding [GO:0001097]; thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; vitamin D receptor binding [GO:0042809]; DNA-templated transcription, initiation [GO:0006352]; intracellular estrogen receptor signaling pathway [GO:0030520]; negative regulation of histone acetylation [GO:0035067]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription initiation from RNA polymerase II promoter [GO:0060260]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermine transport [GO:0000296]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]


uniprotID: O43295
geneSymbol: SRGAP3
reactome: R-HSA-194840;R-HSA-428543;
length: 1099
go: ENSG00000196220;
snps: rs2271207
name:
SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; Rac GTPase binding [GO:0048365]; negative regulation of cell migration [GO:0030336]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=MEGAPa, srGAP3a; IsoId=O43295-1; Sequence=Displayed; Name=2; Synonyms=MEGAPb, srGAP3b; IsoId=O43295-2; Sequence=VSP_010581; Name=3; Synonyms=MEGAPc, srGAP3c; IsoId=O43295-3; Sequence=VSP_010582, VSP_010583; 


uniprotID: O60687
geneSymbol: SRPX2
name: Sushi repeat-containing protein SRPX2 (Sushi-repeat protein upregulated in leukemia)
length: 465
go: ENSG00000102359;
snps: rs121918364 rs17851822 rs121918363
location: SUBCELLULAR LOCATION: Secreted. Cytoplasm. Cell surface. Cell junction, synapse {ECO:0000250}.
sequence:

opentargets:
cell junction [GO:0030054]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; excitatory synapse [GO:0060076]; extracellular space [GO:0005615]; synaptic membrane [GO:0097060]; hepatocyte growth factor binding [GO:0036458]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; angiogenesis [GO:0001525]; cell motility [GO:0048870]; cell-cell adhesion [GO:0098609]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of synapse assembly [GO:0051965]; regulation of phosphorylation [GO:0042325]; vocalization behavior [GO:0071625]


uniprotID: Q9H3Y6
geneSymbol: SRMS
reactome: R-HSA-8849472;
name: Tyrosine-protein kinase Srms (EC 2.7.10.2)
length: 488
go: ENSG00000125508;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; ATP binding [GO:0005524]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

snps:
rs56053583 rs55863722 rs35558836 rs378483 rs34969822 rs310657 rs8122355 rs55838540 rs6011889 rs8120713 rs310655 rs310654 rs33933649 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907}. Note=Localizes to punctate cytoplasmic structures. {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907}.


uniprotID: A1X283
geneSymbol: SH3PXD2B
length: 911
go: ENSG00000174705;
snps: rs267607046 rs6880739
name:
SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)

sequence:

opentargets:
cell junction [GO:0030054]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; podosome [GO:0002102]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; SH2 domain binding [GO:0042169]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; adipose tissue development [GO:0060612]; bone development [GO:0060348]; cranial skeletal system development [GO:1904888]; extracellular matrix disassembly [GO:0022617]; eye development [GO:0001654]; heart development [GO:0007507]; osteoblast fate commitment [GO:0002051]; podosome assembly [GO:0071800]; positive regulation of adipose tissue development [GO:1904179]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to membrane [GO:0072657]; regulation of brood size [GO:0060378]; skeletal system development [GO:0001501]; skeletal system morphogenesis [GO:0048705]; superoxide metabolic process [GO:0006801]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. {ECO:0000250}.


uniprotID: A6NLX3
geneSymbol: SPDYE4
name: Speedy protein E4
length: 237
opentargets: protein kinase binding [GO:0019901]
sequence:


uniprotID: Q24JP5
geneSymbol: TMEM132A
reactome: R-HSA-381426;R-HSA-8957275;
name: Transmembrane protein 132A (HSPA5-binding protein 1)
length: 1023
go: ENSG00000006118;
snps: rs524523 rs2469887
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; cellular protein metabolic process [GO:0044267]; post-translational protein modification [GO:0043687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q24JP5-1; Sequence=Displayed; Name=2; IsoId=Q24JP5-2; Sequence=VSP_025304; Note=No experimental confirmation available.; Name=3; IsoId=Q24JP5-3; Sequence=VSP_025302, VSP_025305, VSP_025306; Note=No experimental confirmation available.; Name=4; IsoId=Q24JP5-4; Sequence=VSP_025303, VSP_025304; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.


uniprotID: Q495Y7
geneSymbol: SPDYE7P
name: Putative speedy protein E7 (Speedy protein E7 pseudogene)
length: 208
opentargets: protein kinase binding [GO:0019901]
sequence:


uniprotID: P35237
geneSymbol: SERPINB6
reactome: R-HSA-6798695;R-HSA-75205;
length: 376
go: ENSG00000124570;
drug: DB00055;
snps: rs2295769 rs2295766
name:
Serpin B6 (Cytoplasmic antiproteinase) (CAP) (Peptidase inhibitor 6) (PI-6) (Placental thrombin inhibitor)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; ficolin-1-rich granule membrane [GO:0101003]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; serine protease inhibitor complex [GO:0097180]; tertiary granule membrane [GO:0070821]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; cellular response to osmotic stress [GO:0071470]; negative regulation of endopeptidase activity [GO:0010951]; neutrophil degranulation [GO:0043312]; sensory perception of sound [GO:0007605]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.


uniprotID: Q5VX52
geneSymbol: SPATA1
name: Spermatogenesis-associated protein 1 (Sperm-specific protein SP-2)
length: 459
go: ENSG00000122432;
snps: rs10493753
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5VX52-1; Sequence=Displayed; Name=2; IsoId=Q5VX52-2; Sequence=VSP_035223, VSP_035224; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q5VX52-4; Sequence=VSP_039875; Note=No experimental confirmation available.; 


uniprotID: Q9UM82
geneSymbol: SPATA2
pdb: 5LJM;5LJN;
name: Spermatogenesis-associated protein 2
length: 520
go: ENSG00000158480;
snps: rs2072985
sequence:

opentargets:
cytoplasm [GO:0005737]; fibrillar center [GO:0001650]; nucleus [GO:0005634]; multicellular organism development [GO:0007275]; programmed cell death [GO:0012501]; protein K63-linked deubiquitination [GO:0070536]; protein linear deubiquitination [GO:1990108]; regulation of inflammatory response [GO:0050727]; regulation of necroptotic process [GO:0060544]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10222154, ECO:0000269|PubMed:11079456}. Nucleus {ECO:0000250|UniProtKB:Q66HP6}. Note=Detected in the tubular compartment of the testis and, in the cytoplasm of the Sertoli cells. {ECO:0000269|PubMed:11079456}.


uniprotID: O75940
geneSymbol: SMNDC1
reactome: R-HSA-72163;
pdb: 4A4F;4A4H;
length: 238
go: ENSG00000119953;
name:
Survival of motor neuron-related-splicing factor 30 (30 kDa splicing factor SMNrp) (SMN-related protein) (Survival motor neuron domain-containing protein 1)

sequence:

opentargets:
Cajal body [GO:0015030]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; apoptotic process [GO:0006915]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]

location:
SUBCELLULAR LOCATION: Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies.


uniprotID: Q8IVW8
geneSymbol: SPNS2
name: Protein spinster homolog 2
length: 549
go: ENSG00000183018;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; sphingolipid transporter activity [GO:0046624]; B cell homeostasis [GO:0001782]; bone development [GO:0060348]; lymph node development [GO:0048535]; lymphocyte migration [GO:0072676]; regulation of eye pigmentation [GO:0048073]; regulation of humoral immune response [GO:0002920]; sphingolipid metabolic process [GO:0006665]; sphingosine-1-phosphate receptor signaling pathway [GO:0003376]; T cell homeostasis [GO:0043029]; transmembrane transport [GO:0055085]


uniprotID: Q8WWL2
geneSymbol: SPIRE2
pdb: 5JCY;
name: Protein spire homolog 2 (Spir-2)
length: 714
go: ENSG00000204991;
drug: DB08080;
sequence:

opentargets:
cell cortex [GO:0005938]; cleavage furrow [GO:0032154]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8WWL2-1; Sequence=Displayed; Name=2; IsoId=Q8WWL2-2; Sequence=VSP_031572; Name=3; IsoId=Q8WWL2-3; Sequence=VSP_031569, VSP_031570; Name=4; IsoId=Q8WWL2-4; Sequence=VSP_031568, VSP_031571; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8K1S6}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8K1S6}. Cell membrane {ECO:0000250|UniProtKB:Q8K1S6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8K1S6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8K1S6}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q8K1S6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8K1S6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8K1S6}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250|UniProtKB:Q8K1S6}.


uniprotID: Q7Z698
geneSymbol: SPRED2
reactome: R-HSA-5658442;R-HSA-5658623;R-HSA-6802949;
pdb: 2JP2;
name: Sprouty-related, EVH1 domain-containing protein 2 (Spred-2)
length: 418
go: ENSG00000198369;
sequence:

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; transport vesicle membrane [GO:0030658]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inactivation of MAPK activity [GO:0000188]; multicellular organism development [GO:0007275]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of protein deacetylation [GO:0090311]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z698-1; Sequence=Displayed; Name=2; IsoId=Q7Z698-2; Sequence=VSP_043755; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q924S7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15580519}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:15580519}. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000269|PubMed:15580519}.


uniprotID: Q5JUX0
geneSymbol: SPIN3
pdb: 5A1H;
name: Spindlin-3 (Spindlin-like protein 3) (SPIN-3)
length: 258
go: ENSG00000204271;
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; gamete generation [GO:0007276]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5JUX0-1; Sequence=Displayed; Name=2; IsoId=Q5JUX0-2; Sequence=VSP_021482, VSP_021483; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q5W111
geneSymbol: SPRYD7
length: 196
go: ENSG00000123178;
name:
SPRY domain-containing protein 7 (Chronic lymphocytic leukemia deletion region gene 6 protein) (CLL deletion region gene 6 protein)

sequence:
MATSVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGTDVVIVKNGRRICGTGGCLASAPLHQNKSYFEFKIQSTGIWGIGVATQKVNLNQIPLGRDMHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5W111-1; Sequence=Displayed; Name=2; IsoId=Q5W111-2; Sequence=VSP_019498; 


uniprotID: Q68D10
geneSymbol: SPTY2D1
pdb: 5BS7;5BSA;
name: Protein SPT2 homolog (Protein KU002155) (SPT2 domain-containing protein 1)
length: 685
go: ENSG00000179119;
snps: rs12795406 rs16935599 rs35411689
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:E1BUG7}.
sequence:

opentargets:
nucleolus [GO:0005730]; DNA binding [GO:0003677]; histone binding [GO:0042393]; RNA polymerase I core binding [GO:0001042]; histone exchange [GO:0043486]; nucleosome assembly [GO:0006334]; regulation of chromatin assembly [GO:0010847]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q68D10-1; Sequence=Displayed; Name=2; IsoId=Q68D10-2; Sequence=VSP_030690; Note=No experimental confirmation available.; Name=3; IsoId=Q68D10-3; Sequence=VSP_030688, VSP_030689; Note=No experimental confirmation available.; 


uniprotID: Q99619
geneSymbol: SPSB2
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 3EMW;5XN3;
name: SPRY domain-containing SOCS box protein 2 (SSB-2) (Gene-rich cluster protein C9)
length: 263
go: ENSG00000111671;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; intracellular signal transduction [GO:0035556]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99619-1; Sequence=Displayed; Name=2; IsoId=Q99619-2; Sequence=VSP_057167; Note=No experimental confirmation available.; 


uniprotID: P49903
geneSymbol: SEPHS1
pdb: 3FD5;3FD6;
name: Selenide, water dikinase 1 (EC 2.7.9.3) (Selenium donor protein 1) (Selenophosphate synthase 1)
length: 392
go: ENSG00000086475;
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; GTP binding [GO:0005525]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; selenide, water dikinase activity [GO:0004756]; cellular protein modification process [GO:0006464]; selenium compound metabolic process [GO:0001887]; selenocysteine biosynthetic process [GO:0016260]; tRNA seleno-modification [GO:0070329]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Major type, MT; IsoId=P49903-1; Sequence=Displayed; Name=2; Synonyms=Delta E8; IsoId=P49903-2; Sequence=VSP_046702; Name=3; Synonyms=Delta E2; IsoId=P49903-3; Sequence=VSP_046701; Name=4; Synonyms=E9 and E9a; IsoId=P49903-4; Sequence=VSP_047451; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane. Nucleus membrane.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.


uniprotID: Q15544
geneSymbol: TAF11
pdb: 1BH8;1BH9;
length: 211
go: ENSG00000064995;
snps: rs15922 rs11537996
location: SUBCELLULAR LOCATION: Nucleus.
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-674695;R-HSA-6804756;R-HSA-6807505;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
Transcription initiation factor TFIID subunit 11 (TFIID subunit p30-beta) (Transcription initiation factor TFIID 28 kDa subunit) (TAF(II)28) (TAFII-28) (TAFII28)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; transcription factor TFIID complex [GO:0005669]; protein heterodimerization activity [GO:0046982]; protein N-terminus binding [GO:0047485]; thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; vitamin D receptor binding [GO:0042809]; positive regulation by host of viral transcription [GO:0043923]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15544-1; Sequence=Displayed; Name=2; IsoId=Q15544-2; Sequence=VSP_044936; Note=No experimental confirmation available.; 


uniprotID: Q01082
geneSymbol: SPTBN1
reactome: R-HSA-373753;R-HSA-375165;R-HSA-445095;R-HSA-5673001;R-HSA-6807878;
pdb: 1AA2;1BKR;3EDV;
length: 2364
go: ENSG00000115306;
drug: DB01373;
snps: rs1052790
name:
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)

sequence:

opentargets:
axolemma [GO:0030673]; cuticular plate [GO:0032437]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; M band [GO:0031430]; nucleolus [GO:0005730]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; spectrin [GO:0008091]; spectrin-associated cytoskeleton [GO:0014731]; actin binding [GO:0003779]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; calmodulin binding [GO:0005516]; GTPase binding [GO:0051020]; phospholipid binding [GO:0005543]; protein-containing complex binding [GO:0044877]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; actin filament capping [GO:0051693]; axon guidance [GO:0007411]; common-partner SMAD protein phosphorylation [GO:0007182]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi to plasma membrane protein transport [GO:0043001]; MAPK cascade [GO:0000165]; membrane assembly [GO:0071709]; mitotic cytokinesis [GO:0000281]; plasma membrane organization [GO:0007009]; positive regulation of interleukin-2 secretion [GO:1900042]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein localization to plasma membrane [GO:0072659]; regulation of protein localization to plasma membrane [GO:1903076]; regulation of SMAD protein signal transduction [GO:0060390]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Long; IsoId=Q01082-1; Sequence=Displayed; Name=Short; IsoId=Q01082-2; Sequence=VSP_000720, VSP_000721; Name=2; IsoId=Q01082-3; Sequence=VSP_026054, VSP_026055, VSP_026056; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q53T94
geneSymbol: TAF1B
reactome: R-HSA-427359;R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 588
go: ENSG00000115750;
snps: rs2303914 rs396190 rs16867223 rs1054565 rs1820965 rs16867245
location: SUBCELLULAR LOCATION: Nucleus, nucleolus.
name:
TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I core factor complex [GO:0070860]; RNA polymerase transcription factor SL1 complex [GO:0005668]; metal ion binding [GO:0046872]; RNA polymerase I CORE element sequence-specific DNA binding [GO:0001164]; TBP-class protein binding [GO:0017025]; nucleolar large rRNA transcription by RNA polymerase I [GO:0042790]; positive regulation of gene expression, epigenetic [GO:0045815]; RNA polymerase I preinitiation complex assembly [GO:0001188]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transcription, DNA-templated [GO:0006351]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q53T94-1; Sequence=Displayed; Name=2; IsoId=Q53T94-2; Sequence=VSP_021677; Note=No experimental confirmation available.; Name=3; IsoId=Q53T94-3; Sequence=VSP_042954; Note=No experimental confirmation available.; 


uniprotID: Q8N103
geneSymbol: TAGAP
reactome: R-HSA-194840;
name: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)
length: 731
go: ENSG00000164691;
snps: rs35263580
sequence:

opentargets:
cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8N103-1; Sequence=Displayed; Name=2; IsoId=Q8N103-2; Sequence=VSP_015869; Name=3; Synonyms=FKSG15; IsoId=Q8N103-3; Sequence=VSP_015868, VSP_015870; Note=No experimental confirmation available. Dubious isoform. The N-terminus appears to be derived from exons of the FGFR1OP locus which is located on the opposing strand of chromosome 6 at a distance of several Mb.; Name=4; IsoId=Q8N103-4; Sequence=VSP_015871, VSP_015872; Note=No experimental confirmation available.; 


uniprotID: Q9BVQ7
geneSymbol: SPATA5L1
name: Spermatogenesis-associated protein 5-like protein 1
length: 753
go: ENSG00000171763;
opentargets: cytoplasm [GO:0005737]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]
snps: rs1153850 rs7182723 rs16943025
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BVQ7-1; Sequence=Displayed; Name=2; IsoId=Q9BVQ7-2; Sequence=VSP_033052, VSP_033053; Note=No experimental confirmation available.; Name=3; IsoId=Q9BVQ7-3; Sequence=VSP_033050, VSP_033051; Note=No experimental confirmation available.; 


uniprotID: Q8N4H0
geneSymbol: SPATA6L
name: Spermatogenesis associated 6-like protein
length: 392
go: ENSG00000106686;
snps: rs10974657 rs16921613
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N4H0-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=2; IsoId=Q8N4H0-2; Sequence=VSP_014315, VSP_014316, VSP_014317; Note=No experimental confirmation available.; Name=3; IsoId=Q8N4H0-3; Sequence=VSP_043770; 


uniprotID: Q86WD7
geneSymbol: SERPINA9
name: Serpin A9 (Centerin) (Germinal center B-cell-expressed transcript 1 protein)
length: 417
go: ENSG00000170054;
snps: rs4905204 rs17090921 rs28583900 rs28618118 rs11628722
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; membrane [GO:0016020]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of endopeptidase activity [GO:0010951]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=A; IsoId=Q86WD7-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q86WD7-2; Sequence=VSP_041491, VSP_041493; Name=3; Synonyms=SERPINA11a; IsoId=Q86WD7-3; Sequence=VSP_041492; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=4; Synonyms=SERPINA11b; IsoId=Q86WD7-4; Sequence=VSP_041490, VSP_041494, VSP_041495; Name=5; IsoId=Q86WD7-5; Sequence=VSP_041488; Name=6; IsoId=Q86WD7-6; Sequence=VSP_041489; Name=7; IsoId=Q86WD7-7; Sequence=VSP_041491; 

location:
SUBCELLULAR LOCATION: Isoform 1: Secreted.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 5: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 6: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 7: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.


uniprotID: A0A1B0GVQ0
geneSymbol: SPAAR
name: Small regulatory polypeptide of amino acid response
sequence: MGAKAPRGPKVAQWAMETAVIGVVVVLFVVTVAITCVLCCFSCDSRAQDPQGGPGRSFTVATFRQEASLFTGPVRHAQPVPSAQDFWTFM
length: 90
go: ENSG00000235387;
opentargets:
integral component of lysosomal membrane [GO:1905103]; late endosome membrane [GO:0031902]; cellular response to amino acid stimulus [GO:0071230]; negative regulation of TORC1 signaling [GO:1904262]; regulation of skeletal muscle tissue regeneration [GO:0043416]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=1 {ECO:0000305|PubMed:28024296}; IsoId=A0A1B0GVQ0-1; Sequence=Displayed; Name=2 {ECO:0000305|PubMed:28024296}; IsoId=A0A1B0GVQ0-2; Sequence=VSP_058780; 

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:28024296}; Single-pass membrane protein {ECO:0000305|PubMed:28024296}. Lysosome membrane {ECO:0000269|PubMed:28024296}; Single-pass membrane protein {ECO:0000305|PubMed:28024296}.


uniprotID: P0CI01
geneSymbol: SPDYE6
name: Speedy protein E6
length: 402
opentargets: protein kinase binding [GO:0019901]
sequence:


uniprotID: Q9HD40
geneSymbol: SEPSECS
reactome: R-HSA-2408557;
pdb: 3HL2;4ZDL;4ZDO;4ZDP;
length: 501
go: ENSG00000109618;
drug: DB00114;
snps: rs267607035 rs267607036
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
name:
O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Liver-pancreas antigen) (LP) (SLA-p35) (SLA/LP autoantigen) (Selenocysteine synthase) (Sec synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) (SepSecS) (Soluble liver antigen) (SLA) (UGA suppressor tRNA-associated protein) (tRNA(Ser/Sec)-associated antigenic protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; phosphoseryl-selenocysteinyl-tRNA selenium transferase activity [GO:0098621]; tRNA binding [GO:0000049]; selenocysteine incorporation [GO:0001514]; selenocysteine metabolic process [GO:0016259]; selenocysteinyl-tRNA(Sec) biosynthetic process [GO:0097056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9HD40-1; Sequence=Displayed; Name=2; IsoId=Q9HD40-2; Sequence=VSP_038078, VSP_038079; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=3; IsoId=Q9HD40-3; Sequence=VSP_038080; 


uniprotID: Q9Y4P9
geneSymbol: SPEF1
pdb: 2EE7;
name: Sperm flagellar protein 1
length: 236
go: ENSG00000101222;
sequence:

opentargets:
axoneme [GO:0005930]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; microtubule binding [GO:0008017]; cell migration [GO:0016477]; cilium-dependent cell motility [GO:0060285]; negative regulation of microtubule depolymerization [GO:0007026]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y4P9-1; Sequence=Displayed; Note=Gene prediction based on EST data. No experimental confirmation available.; Name=2; IsoId=Q9Y4P9-2; Sequence=VSP_017219, VSP_017220; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99JL1}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q99JL1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0IH24}. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). {ECO:0000250}.


uniprotID: O95149
geneSymbol: SNUPN
reactome: R-HSA-191859;
pdb: 1XK5;2P8Q;2Q5D;2QNA;3GB8;3GJX;3LWW;3NBY;3NBZ;3NC0;5DIS;
name: Snurportin-1 (RNA U transporter 1)
length: 360
go: ENSG00000169371;
sequence:

opentargets:
cytosol [GO:0005829]; nuclear pore [GO:0005643]; nuclear import signal receptor activity [GO:0061608]; RNA cap binding [GO:0000339]; import into nucleus [GO:0051170]; protein import into nucleus [GO:0006606]; snRNA import into nucleus [GO:0061015]; spliceosomal snRNP assembly [GO:0000387]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:15920472}. Cytoplasm {ECO:0000269|PubMed:12095920, ECO:0000269|PubMed:9670026, ECO:0000305|PubMed:10209022}. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022). {ECO:0000269|PubMed:10209022, ECO:0000269|PubMed:12095920}.


uniprotID: Q9BYE4
geneSymbol: SPRR2G
reactome: R-HSA-6809371;
name: Small proline-rich protein 2G (SPR-2G)
sequence: MSYQQQQCKQPCQPPPVCPTPKCPEPCPPPKCPEPYLPPPCPPEHCPPPPCQDKCPPVQPYPPCQQKYPPKSK
length: 73
go: ENSG00000159516;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
opentargets:
cornified envelope [GO:0001533]; cytosol [GO:0005829]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]


uniprotID: Q0P670
geneSymbol: SPEM2
name: Uncharacterized protein SPEM2
length: 501
go: ENSG00000184560;
opentargets: integral component of membrane [GO:0016021]
snps: rs13290 rs3892554
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: P09486
geneSymbol: SPARC
reactome: R-HSA-114608;R-HSA-3000178;R-HSA-3000497;
pdb: 1BMO;1NUB;1SRA;2V53;
length: 303
go: ENSG00000113140;
snps: rs6874468 rs13359508 rs1057517662 rs1057517663
name:
SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)

sequence:

opentargets:
basement membrane [GO:0005604]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle lumen [GO:0071682]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; nuclear matrix [GO:0016363]; platelet alpha granule [GO:0031091]; platelet alpha granule lumen [GO:0031093]; platelet alpha granule membrane [GO:0031092]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; bone development [GO:0060348]; cellular response to growth factor stimulus [GO:0071363]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; inner ear development [GO:0048839]; lung development [GO:0030324]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell proliferation [GO:0001937]; ossification [GO:0001503]; pigmentation [GO:0043473]; platelet degranulation [GO:0002576]; positive regulation of endothelial cell migration [GO:0010595]; receptor-mediated endocytosis [GO:0006898]; regulation of cell morphogenesis [GO:0022604]; regulation of synapse organization [GO:0050807]; response to cadmium ion [GO:0046686]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to cytokine [GO:0034097]; response to ethanol [GO:0045471]; response to glucocorticoid [GO:0051384]; response to gravity [GO:0009629]; response to L-ascorbic acid [GO:0033591]; response to lead ion [GO:0010288]; response to lipopolysaccharide [GO:0032496]; response to peptide hormone [GO:0043434]; wound healing [GO:0042060]

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.


uniprotID: Q9UBC9
geneSymbol: SPRR3
reactome: R-HSA-6809371;
name: Small proline-rich protein 3 (22 kDa pancornulin) (Cornifin beta) (Esophagin)
length: 169
go: ENSG00000163209;
snps: rs1055935 rs2075740
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:
MSSYQQKQTFTPPPQLQQQQVKQPSQPPPQEIFVPTTKEPCHSKVPQPGNTKIPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGCTKVPEPGYTKVPEPGSIKVPDQGFIKFPEPGAIKVPEQGYTKVPVPGYTKLPEPCPSTVTPGPAQQKTKQK

opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; structural molecule activity [GO:0005198]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]; wound healing [GO:0042060]


uniprotID: P35346
geneSymbol: SSTR5
reactome: R-HSA-375276;R-HSA-418594;
name: Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R)
length: 364
go: ENSG00000162009;
drug: DB06791;DB00104;DB06663;DB04894;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; neuropeptide binding [GO:0042923]; somatostatin receptor activity [GO:0004994]; cellular response to glucocorticoid stimulus [GO:0071385]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; glucose homeostasis [GO:0042593]; negative regulation of cell proliferation [GO:0008285]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]; regulation of insulin secretion [GO:0050796]

snps:
rs4988482 rs4988483 rs4988484 rs34803074 rs4988487 rs34070276 rs34474910 rs35125411 rs12596873 rs169068 rs35072648 rs34947461 


uniprotID: P61011
geneSymbol: SRP54
reactome: R-HSA-1799339;
pdb: 1MFQ;1QB2;5L3Q;
name: Signal recognition particle 54 kDa protein (SRP54)
length: 504
go: ENSG00000100883;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; drug binding [GO:0008144]; endoplasmic reticulum signal peptide binding [GO:0030942]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; protein targeting to ER [GO:0045047]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [GO:0006617]; SRP-dependent cotranslational protein targeting to membrane, translocation [GO:0006616]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P61011-1; Sequence=Displayed; Name=2; IsoId=P61011-2; Sequence=VSP_043696; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14729963}. Cytoplasm {ECO:0000269|PubMed:14729963}.


uniprotID: Q9NQ55
geneSymbol: PPAN
name: Suppressor of SWI4 1 homolog (Ssf-1) (Brix domain-containing protein 3) (Peter Pan homolog)
length: 473
go: ENSG00000130810;ENSG00000243207;
snps: rs2305793 rs11559188
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; ribosomal large subunit assembly [GO:0000027]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NQ55-1; Sequence=Displayed; Name=2; IsoId=Q9NQ55-2; Sequence=VSP_003973; Note=No experimental confirmation available.; Name=3; IsoId=Q9NQ55-3; Sequence=VSP_046377; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q01995
geneSymbol: TAGLN
length: 201
go: ENSG00000149591;
snps: rs12284316
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
name:
Transgelin (22 kDa actin-binding protein) (Protein WS3-10) (Smooth muscle protein 22-alpha) (SM22-alpha)

sequence:

opentargets:
cytoplasm [GO:0005737]; actin filament binding [GO:0051015]; epithelial cell differentiation [GO:0030855]; muscle organ development [GO:0007517]


uniprotID: Q08AE8
geneSymbol: SPIRE1
pdb: 2YLE;2YLF;3R7G;3RBW;
name: Protein spire homolog 1 (Spir-1)
length: 756
go: ENSG00000134278;
snps: rs1785296
sequence:

opentargets:
cell cortex [GO:0005938]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; actin binding [GO:0003779]; actin cytoskeleton organization [GO:0030036]; actin nucleation [GO:0045010]; cleavage furrow formation [GO:0036089]; establishment of meiotic spindle localization [GO:0051295]; formin-nucleated actin cable assembly [GO:0070649]; intracellular transport [GO:0046907]; polar body extrusion after meiotic divisions [GO:0040038]; positive regulation of double-strand break repair [GO:2000781]; protein transport [GO:0015031]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1 {ECO:0000269|PubMed:15489334}; IsoId=Q08AE8-1; Sequence=Displayed; Note=No experimental confirmation available. {ECO:0000305}; Name=5; IsoId=Q08AE8-5; Sequence=VSP_054464, VSP_052595; Note=No experimental confirmation available. Derived from EST data.; Name=2 {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:15489334}; IsoId=Q08AE8-2; Sequence=VSP_052595; Name=3; IsoId=Q08AE8-3; Sequence=VSP_037925, VSP_052595; Name=4; IsoId=Q08AE8-4; Sequence=VSP_037925, VSP_052595, VSP_037926; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q52KF3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q52KF3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q52KF3}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity). {ECO:0000250|UniProtKB:Q52KF3}.


uniprotID: Q9NS26
geneSymbol: SPANXA1; SPANXA2
sequence: MDKQSSAGGVKRSVPCDSNEANEMMPETPTGDSDPQPAPKKMKTSESSTILVVRYRRNFKRTSPEELLNDHARENRINPLQMEEEEFMEIMVEIPAK
length: 97
go: ENSG00000198021;
opentargets: cytoplasm [GO:0005737]; nucleus [GO:0005634]; spermatogenesis [GO:0007283]
name:
Sperm protein associated with the nucleus on the X chromosome A (Cancer/testis antigen 11.1) (CT11.1) (Nuclear-associated protein SPAN-Xa) (SPAN-X) (SPANX-A) (SPANX family member A)

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10906052}. Nucleus {ECO:0000269|PubMed:10906052}. Note=Associated with nuclear craters.


uniprotID: O43291
geneSymbol: SPINT2
reactome: R-HSA-6806942;R-HSA-8852405;
pdb: 4U32;
length: 252
go: ENSG00000167642;
snps: rs121908403 rs11548457
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
Kunitz-type protease inhibitor 2 (Hepatocyte growth factor activator inhibitor type 2) (HAI-2) (Placental bikunin)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; endopeptidase inhibitor activity [GO:0004866]; serine-type endopeptidase inhibitor activity [GO:0004867]; basement membrane organization [GO:0071711]; cellular response to BMP stimulus [GO:0071773]; epithelial cell morphogenesis involved in placental branching [GO:0060672]; establishment or maintenance of cell polarity [GO:0007163]; negative regulation of cell motility [GO:2000146]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43291-1; Sequence=Displayed; Name=2; IsoId=O43291-2; Sequence=VSP_043680; Note=No experimental confirmation available.; 


uniprotID: Q8NA61
geneSymbol: SPERT
name: Spermatid-associated protein (Protein chibby homolog 2)
length: 448
go: ENSG00000174015;
opentargets: cytoplasmic vesicle [GO:0031410]; identical protein binding [GO:0042802]
snps: rs7317245
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NA61-1; Sequence=Displayed; Name=2; IsoId=Q8NA61-2; Sequence=VSP_028673, VSP_028674; 


uniprotID: Q8NCJ5
geneSymbol: SPRYD3
pdb: 2YYO;
name: SPRY domain-containing protein 3
length: 442
go: ENSG00000167778;
sequence:


uniprotID: Q56A73
geneSymbol: SPIN4
pdb: 4UY4;
name: Spindlin-4
length: 249
go: ENSG00000186767;
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; methylated histone binding [GO:0035064]; gamete generation [GO:0007276]


uniprotID: Q12962
geneSymbol: TAF10
pdb: 2F69;3M53;3M54;3M55;3M56;3M57;3M58;3M59;3M5A;4J7F;4J7I;4J83;4J8O;4WV4;5EG2;
length: 218
go: ENSG00000166337;
snps: rs3176311
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-3214847;R-HSA-5689880;R-HSA-674695;R-HSA-6804756;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
Transcription initiation factor TFIID subunit 10 (STAF28) (Transcription initiation factor TFIID 30 kDa subunit) (TAF(II)30) (TAFII-30) (TAFII30)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCAF complex [GO:0000125]; perinuclear region of cytoplasm [GO:0048471]; STAGA complex [GO:0030914]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; estrogen receptor binding [GO:0030331]; RNA polymerase binding [GO:0070063]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; cellular protein-containing complex assembly [GO:0034622]; DNA-templated transcription, initiation [GO:0006352]; G1/S transition of mitotic cell cycle [GO:0000082]; hepatocyte differentiation [GO:0070365]; histone deubiquitination [GO:0016578]; histone H3 acetylation [GO:0043966]; multicellular organism growth [GO:0035264]; protein deubiquitination [GO:0016579]; protein homooligomerization [GO:0051260]; regulation of DNA binding [GO:0051101]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription, DNA-templated [GO:0006355]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:9674425}.


uniprotID: Q6ZMY3
geneSymbol: SPOCD1
name: SPOC domain-containing protein 1
length: 1216
go: ENSG00000134668;
opentargets: negative regulation of phosphatase activity [GO:0010923]; transcription, DNA-templated [GO:0006351]
snps: rs6664445 rs6669563
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q6ZMY3-1; Sequence=Displayed; Name=2; IsoId=Q6ZMY3-2; Sequence=VSP_025497; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZMY3-3; Sequence=VSP_025490, VSP_025497; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZMY3-4; Sequence=VSP_025489, VSP_025494, VSP_025495, VSP_025496; Note=No experimental confirmation available.; Name=5; IsoId=Q6ZMY3-5; Sequence=VSP_025491, VSP_025492, VSP_025493; Note=No experimental confirmation available.; 


uniprotID: Q96LK8
geneSymbol: SPATA32
name: Spermatogenesis-associated protein 32 (Testis-expressed protein 34)
length: 384
go: ENSG00000184361;
snps: rs11651968
sequence:

opentargets:
perinuclear region of cytoplasm [GO:0048471]; actin binding [GO:0003779]; spermatogenesis [GO:0007283]


uniprotID: Q8N9Q2
geneSymbol: SREK1IP1
length: 155
go: ENSG00000153006;
name:
Protein SREK1IP1 (SFRS12-interacting protein 1) (SREK1-interacting protein 1) (Splicing regulatory protein of 18 kDa) (p18SRP)

sequence:
MAVPGCNKDSVRAGCKKCGYPGHLTFECRNFLRVDPKRDIVLDVSSTSSEDSDEENEELNKLQALQEKRINEEEEKKKEKSKEKIKLKKKRKRSYSSSSTEEDTSKQKKQKYQKKEKKKEKKSKSKKGKHHKKEKKKRKKEKHSSTPNSSEFSRK

opentargets:
nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; mRNA processing [GO:0006397]; RNA splicing [GO:0008380]


uniprotID: Q15543
geneSymbol: TAF13
pdb: 1BH8;1BH9;
length: 124
go: ENSG00000197780;
snps: rs1060505030 rs1060505029
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9695952}.
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-674695;R-HSA-6804756;R-HSA-6807505;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
Transcription initiation factor TFIID subunit 13 (Transcription initiation factor TFIID 18 kDa subunit) (TAF(II)18) (TAFII-18) (TAFII18)

sequence:
MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; protein C-terminus binding [GO:0008022]; protein heterodimerization activity [GO:0046982]; transcription coregulator activity [GO:0003712]; DNA-templated transcription, initiation [GO:0006352]; regulation of signal transduction by p53 class mediator [GO:1901796]; regulation of transcription by RNA polymerase II [GO:0006357]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]


uniprotID: Q9Y6N5
geneSymbol: SQOR
reactome: R-HSA-1614517;
length: 450
go: ENSG00000137767;
snps: rs1044032
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
name:
Sulfide:quinone oxidoreductase, mitochondrial (SQOR) (EC 1.8.5.-) (Sulfide dehydrogenase-like) (Sulfide quinone oxidoreductase)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; FAD binding [GO:0071949]; quinone binding [GO:0048038]; sulfide:quinone oxidoreductase activity [GO:0070224]; hydrogen sulfide metabolic process [GO:0070813]; sulfide oxidation, using sulfide:quinone oxidoreductase [GO:0070221]


uniprotID: Q7KZ85
geneSymbol: SUPT6H
reactome: R-HSA-112382;R-HSA-674695;R-HSA-75955;
pdb: 6GME;6GMH;
length: 1726
go: ENSG00000109111;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription elongation factor complex [GO:0008023]; transcriptionally active chromatin [GO:0035327]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; histone binding [GO:0042393]; nucleosome binding [GO:0031491]; RNA binding [GO:0003723]; blastocyst formation [GO:0001825]; chromatin maintenance [GO:0070827]; chromatin remodeling [GO:0006338]; mRNA processing [GO:0006397]; mRNA transcription by RNA polymerase II [GO:0042789]; mRNA transport [GO:0051028]; negative regulation of histone H3-K27 methylation [GO:0061086]; nucleosome organization [GO:0034728]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; regulation of isotype switching [GO:0045191]; regulation of mRNA export from nucleus [GO:0010793]; regulation of mRNA processing [GO:0050684]; regulation of muscle cell differentiation [GO:0051147]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7KZ85-1; Sequence=Displayed; Name=2; IsoId=Q7KZ85-2; Sequence=VSP_011505, VSP_011506; Name=3; IsoId=Q7KZ85-3; Sequence=VSP_011507; 


uniprotID: Q8NEQ6
geneSymbol: SRARP
length: 169
go: ENSG00000183888;
snps: rs34950166
name:
Steroid receptor-associated and regulated protein (ER-related factor) (Steroid receptor-regulated protein)

sequence:
MAPSEDPRDWRANLKGTIRETGLETSSGGKLAGHQKTVPTAHLTFVIDCTHGKQLSLAATASPPQAPSPNRGLVTPPMKTYIVFCGENWPHLTRVTPMGGGCLAQARATLPLCRGSVASASFPVSPLCPQEVPEAKGKPVKAAPVRSSTWGTVKDSLKALSSCVCGQAD


uniprotID: P36956
geneSymbol: SREBF1
reactome: R-HSA-1368082;R-HSA-1655829;R-HSA-1989781;R-HSA-2426168;R-HSA-381340;
pdb: 1AM9;
length: 1147
go: ENSG00000072310;
snps: rs17855793 rs35188700 rs2229590 rs36215896 rs2228461 rs17855792 rs1042017 rs35014224
name:
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme activator activity [GO:0008047]; nuclear receptor activity [GO:0004879]; protein dimerization activity [GO:0046983]; protein kinase binding [GO:0019901]; protein-containing complex binding [GO:0044877]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sterol response element binding [GO:0032810]; aging [GO:0007568]; cellular response to fatty acid [GO:0071398]; cellular response to starvation [GO:0009267]; cholesterol metabolic process [GO:0008203]; circadian rhythm [GO:0007623]; fat cell differentiation [GO:0045444]; insulin receptor signaling pathway [GO:0008286]; lipid biosynthetic process [GO:0008610]; lipid metabolic process [GO:0006629]; lung development [GO:0030324]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of insulin secretion [GO:0046676]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cholesterol biosynthetic process [GO:0045542]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of fatty acid metabolic process [GO:0019217]; regulation of heart rate by chemical signal [GO:0003062]; regulation of protein stability [GO:0031647]; regulation of protein targeting to mitochondrion [GO:1903214]; regulation of transcription by RNA polymerase II [GO:0006357]; response to cAMP [GO:0051591]; response to food [GO:0032094]; response to glucagon [GO:0033762]; response to glucose [GO:0009749]; response to progesterone [GO:0032570]; response to retinoic acid [GO:0032526]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist.; Name=SREBP-1A; IsoId=P36956-1; Sequence=Displayed; Name=SREBP-1B; IsoId=P36956-2; Sequence=VSP_002150; Name=SREBP-1C; IsoId=P36956-3; Sequence=VSP_002149, VSP_002150; Note=Predominantly expressed in liver and adipose tissues.; Name=4; IsoId=P36956-4; Sequence=VSP_030859; Note=No experimental confirmation available.; Name=SREBP-1aDelta; IsoId=P36956-5; Sequence=VSP_047598, VSP_047599; Note=The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.; Name=SREBP-1cDelta; IsoId=P36956-6; Sequence=VSP_002149, VSP_047598, VSP_047599; Note=The absence of Golgi proteolytic processing requirement makes this isoform constitutively active in transactivation of lipogenic gene promoters.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein {ECO:0000255}. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. {ECO:0000250|UniProtKB:Q9WTN3}.; SUBCELLULAR LOCATION: Processed sterol regulatory element-binding protein 1: Nucleus {ECO:0000250|UniProtKB:Q9WTN3}.; SUBCELLULAR LOCATION: Isoform SREBP-1aDelta: Nucleus {ECO:0000269|PubMed:18267114}.; SUBCELLULAR LOCATION: Isoform SREBP-1cDelta: Nucleus {ECO:0000269|PubMed:18267114}.


uniprotID: Q12772
geneSymbol: SREBF2
reactome: R-HSA-1655829;R-HSA-1989781;R-HSA-2426168;R-HSA-381340;
pdb: 1UKL;
length: 1141
go: ENSG00000198911;
snps: rs17002714 rs2228314 rs2229440 rs2228313
name:
Sterol regulatory element-binding protein 2 (SREBP-2) (Class D basic helix-loop-helix protein 2) (bHLHd2) (Sterol regulatory element-binding transcription factor 2) [Cleaved into: Processed sterol regulatory element-binding protein 2]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; SREBP-SCAP-Insig complex [GO:0032937]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; protein C-terminus binding [GO:0008022]; protein dimerization activity [GO:0046983]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to low-density lipoprotein particle stimulus [GO:0071404]; cellular response to starvation [GO:0009267]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; lipid metabolic process [GO:0006629]; negative regulation of cholesterol efflux [GO:0090370]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cholesterol storage [GO:0010886]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of protein targeting to mitochondrion [GO:1903955]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of autophagy of mitochondrion [GO:1903146]; regulation of cholesterol biosynthetic process [GO:0045540]; regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [GO:0072368]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q12772-1; Sequence=Displayed; Name=2; IsoId=Q12772-2; Sequence=VSP_054283, VSP_054284, VSP_054285; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.; SUBCELLULAR LOCATION: Processed sterol regulatory element-binding protein 2: Nucleus {ECO:0000250|UniProtKB:Q3U1N2}.


uniprotID: Q8WXA9
geneSymbol: SREK1
length: 508
go: ENSG00000153914;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WXA9-1; Sequence=Displayed; Name=2; IsoId=Q8WXA9-2; Sequence=VSP_008399; Note=No experimental confirmation available.; 


uniprotID: P23327
geneSymbol: HRC
reactome: R-HSA-381426;R-HSA-8957275;
name: Sarcoplasmic reticulum histidine-rich calcium-binding protein
length: 699
go: ENSG00000130528;
snps: rs3745298 rs3745297
location: SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen.
sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; sarcoplasmic reticulum lumen [GO:0033018]; sarcoplasmic reticulum membrane [GO:0033017]; Z disc [GO:0030018]; ATPase binding [GO:0051117]; calcium ion binding [GO:0005509]; ion channel binding [GO:0044325]; cellular protein metabolic process [GO:0044267]; muscle contraction [GO:0006936]; positive regulation of heart contraction [GO:0045823]; positive regulation of heart rate [GO:0010460]; positive regulation of relaxation of cardiac muscle [GO:1901899]; post-translational protein modification [GO:0043687]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [GO:0010881]; regulation of cell communication by electrical coupling involved in cardiac conduction [GO:1901844]; regulation of cytosolic calcium ion concentration [GO:0051480]; regulation of heart rate [GO:0002027]; regulation of peptidyl-serine phosphorylation [GO:0033135]; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [GO:0010880]; regulation of ryanodine-sensitive calcium-release channel activity [GO:0060314]


uniprotID: A1L4H1
geneSymbol: SSC5D
reactome: R-HSA-3000471;
length: 1573
go: ENSG00000179954;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}.
name:
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (Soluble scavenger protein with 5 SRCR domains) (SSc5D)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; external side of plasma membrane [GO:0009897]; extracellular space [GO:0005615]; intracellular [GO:0005622]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; scavenger receptor activity [GO:0005044]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterial lipoprotein [GO:0042494]; innate immune response [GO:0045087]; multicellular organism development [GO:0007275]; negative regulation of interleukin-8 secretion [GO:2000483]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A1L4H1-1; Sequence=Displayed; Name=2; IsoId=A1L4H1-2; Sequence=VSP_040792, VSP_040793; 


uniprotID: P12931
geneSymbol: SRC
length: 536
go: ENSG00000197122;
snps: rs6018260 rs34881773 rs879255268
reactome:
R-HSA-1227986;R-HSA-1257604;R-HSA-1295596;R-HSA-1433557;R-HSA-1433559;R-HSA-171007;R-HSA-177929;R-HSA-180292;R-HSA-186763;R-HSA-191647;R-HSA-2029481;R-HSA-210990;R-HSA-2219530;R-HSA-2682334;R-HSA-354192;R-HSA-354194;R-HSA-372708;R-HSA-375165;R-HSA-389356;R-HSA-389513;R-HSA-391160;R-HSA-3928662;R-HSA-3928663;R-HSA-3928664;R-HSA-3928665;R-HSA-418592;R-HSA-418885;R-HSA-418886;R-HSA-428542;R-HSA-430116;R-HSA-437239;R-HSA-4420097;R-HSA-456926;R-HSA-5218921;R-HSA-5607764;R-HSA-5663220;R-HSA-5673000;R-HSA-5674135;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802955;R-HSA-6811558;R-HSA-69231;R-HSA-8853659;R-HSA-8874081;R-HSA-8876493;R-HSA-8934593;R-HSA-8934903;R-HSA-8940973;R-HSA-8941858;R-HSA-9032500;R-HSA-9603381;

pdb:
1A07;1A08;1A09;1A1A;1A1B;1A1C;1A1E;1FMK;1HCS;1HCT;1KSW;1O41;1O42;1O43;1O44;1O45;1O46;1O47;1O48;1O49;1O4A;1O4B;1O4C;1O4D;1O4E;1O4F;1O4G;1O4H;1O4I;1O4J;1O4K;1O4L;1O4M;1O4N;1O4O;1O4P;1O4Q;1O4R;1SHD;1Y57;1YI6;1YOJ;1YOL;1YOM;2BDF;2BDJ;2H8H;2SRC;3VRO;3ZMP;3ZMQ;4F59;4F5A;4F5B;4HXJ;4K11;4MXO;4MXX;4MXY;4MXZ;

name:
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)

sequence:

opentargets:
actin filament [GO:0005884]; caveola [GO:0005901]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosome [GO:0005764]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; podosome [GO:0002102]; postsynaptic density [GO:0014069]; postsynaptic specialization, intracellular component [GO:0099091]; ruffle membrane [GO:0032587]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; connexin binding [GO:0071253]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; estrogen receptor binding [GO:0030331]; growth factor receptor binding [GO:0070851]; heme binding [GO:0020037]; insulin receptor binding [GO:0005158]; integrin binding [GO:0005178]; ion channel binding [GO:0044325]; kinase activity [GO:0016301]; kinase binding [GO:0019900]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; phosphoprotein binding [GO:0051219]; protein C-terminus binding [GO:0008022]; protein kinase activity [GO:0004672]; protein kinase C binding [GO:0005080]; protein tyrosine kinase activity [GO:0004713]; scaffold protein binding [GO:0097110]; SH2 domain binding [GO:0042169]; SH3/SH2 adaptor activity [GO:0005070]; signaling receptor binding [GO:0005102]; ubiquitin protein ligase binding [GO:0031625]; activation of protein kinase B activity [GO:0032148]; adherens junction organization [GO:0034332]; angiotensin-activated signaling pathway involved in heart process [GO:0086098]; axon guidance [GO:0007411]; bone resorption [GO:0045453]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cell cycle [GO:0007049]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cell-cell adhesion [GO:0098609]; cellular response to fatty acid [GO:0071398]; cellular response to fluid shear stress [GO:0071498]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to progesterone stimulus [GO:0071393]; cellular response to reactive oxygen species [GO:0034614]; entry of bacterium into host cell [GO:0035635]; ephrin receptor signaling pathway [GO:0048013]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; forebrain development [GO:0030900]; integrin-mediated signaling pathway [GO:0007229]; intracellular signal transduction [GO:0035556]; leukocyte migration [GO:0050900]; macroautophagy [GO:0016236]; negative regulation of anoikis [GO:2000811]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of mitochondrial depolarization [GO:0051902]; negative regulation of protein homooligomerization [GO:0032463]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of transcription, DNA-templated [GO:0045892]; neurotrophin TRK receptor signaling pathway [GO:0048011]; oogenesis [GO:0048477]; osteoclast development [GO:0036035]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045737]; positive regulation of cytokine secretion [GO:0050715]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of integrin activation [GO:0033625]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of non-membrane spanning protein tyrosine kinase activity [GO:1903997]; positive regulation of ovarian follicle development [GO:2000386]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of platelet-derived growth factor receptor signaling pathway [GO:0010641]; positive regulation of podosome assembly [GO:0071803]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of protein processing [GO:0010954]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of small GTPase mediated signal transduction [GO:0051057]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of transcription, DNA-templated [GO:0045893]; primary ovarian follicle growth [GO:0001545]; progesterone receptor signaling pathway [GO:0050847]; protein autophosphorylation [GO:0046777]; protein destabilization [GO:0031648]; regulation of bone resorption [GO:0045124]; regulation of caveolin-mediated endocytosis [GO:2001286]; regulation of cell projection assembly [GO:0060491]; regulation of cell-cell adhesion [GO:0022407]; regulation of early endosome to late endosome transport [GO:2000641]; regulation of epithelial cell migration [GO:0010632]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of postsynaptic neurotransmitter receptor activity [GO:0098962]; regulation of protein binding [GO:0043393]; regulation of vascular permeability [GO:0043114]; response to acidic pH [GO:0010447]; response to electrical stimulus [GO:0051602]; response to hydrogen peroxide [GO:0042542]; response to interleukin-1 [GO:0070555]; response to mechanical stimulus [GO:0009612]; response to mineralocorticoid [GO:0051385]; response to nutrient levels [GO:0031667]; response to virus [GO:0009615]; signal complex assembly [GO:0007172]; signal transduction [GO:0007165]; stimulatory C-type lectin receptor signaling pathway [GO:0002223]; stress fiber assembly [GO:0043149]; substrate adhesion-dependent cell spreading [GO:0034446]; T cell costimulation [GO:0031295]; transcytosis [GO:0045056]; transforming growth factor beta receptor signaling pathway [GO:0007179]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; uterus development [GO:0060065]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]

drug:
DB08564;DB06882;DB06883;DB08192;DB04739;DB07966;DB06616;DB04272;DB01254;DB03217;DB03628;DB02175;DB08462;DB07662;DB01893;DB09079;DB03902;DB03114;DB03078;DB03298;DB01962;DB08901;DB04751;DB04080;DB01947;DB03828;DB03306;DB02908;DB02762;DB03525;DB01866;DB04495;DB03104;DB03268;DB03591;DB02336;DB01678;DB03712;DB01908;DB02432;DB05184;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P12931-1; Sequence=Displayed; Name=2; IsoId=P12931-2; Sequence=VSP_012134; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7525268}. Mitochondrion inner membrane {ECO:0000269|PubMed:12615910}. Nucleus {ECO:0000269|PubMed:7853507}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7525268}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19307596}. Note=Localizes to focal adhesion sites following integrin engagement. Localization to focal adhesion sites requires myristoylation and the SH3 domain (PubMed:7525268). Colocalizes with PDLIM4 at the perinuclear region, but not at focal adhesions (PubMed:19307596). {ECO:0000269|PubMed:19307596, ECO:0000269|PubMed:7525268}.


uniprotID: Q9HBM6
geneSymbol: TAF9B
length: 251
go: ENSG00000187325;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-5689880;R-HSA-674695;R-HSA-6804756;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
Transcription initiation factor TFIID subunit 9B (Neuronal cell death-related protein 7) (DN-7) (Transcription initiation factor TFIID subunit 9-like) (Transcription-associated factor TAFII31L)

sequence:

opentargets:
nucleoplasm [GO:0005654]; SAGA complex [GO:0000124]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; protein heterodimerization activity [GO:0046982]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; histone H3 acetylation [GO:0043966]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cell growth [GO:0030307]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; RNA polymerase II preinitiation complex assembly [GO:0051123]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]


uniprotID: Q16594
geneSymbol: TAF9
length: 264
go: ENSG00000273841;
snps: rs4252233 rs11542580
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:9674425}.
reactome:
R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-3214847;R-HSA-674695;R-HSA-6804756;R-HSA-6807505;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-76042;

name:
Transcription initiation factor TFIID subunit 9 (RNA polymerase II TBP-associated factor subunit G) (STAF31/32) (Transcription initiation factor TFIID 31 kDa subunit) (TAFII-31) (TAFII31) (Transcription initiation factor TFIID 32 kDa subunit) (TAFII-32) (TAFII32)

sequence:

opentargets:
MLL1 complex [GO:0071339]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PCAF complex [GO:0000125]; pre-snoRNP complex [GO:0070761]; SAGA complex [GO:0000124]; STAGA complex [GO:0030914]; transcription factor TFIID complex [GO:0005669]; transcription factor TFTC complex [GO:0033276]; activating transcription factor binding [GO:0033613]; ATPase binding [GO:0051117]; C2H2 zinc finger domain binding [GO:0070742]; DNA binding [GO:0003677]; p53 binding [GO:0002039]; protein heterodimerization activity [GO:0046982]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; box C/D snoRNP assembly [GO:0000492]; cellular response to DNA damage stimulus [GO:0006974]; histone H3 acetylation [GO:0043966]; negative regulation of apoptotic process [GO:0043066]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; positive regulation of cell growth [GO:0030307]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to interleukin-1 [GO:0070555]; RNA polymerase II preinitiation complex assembly [GO:0051123]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription initiation from RNA polymerase II promoter [GO:0006367]


uniprotID: Q9BXP5
geneSymbol: SRRT
reactome: R-HSA-6807505;R-HSA-72163;
pdb: 5OO6;6F7J;6F7P;6F7S;6F8D;
name: Serrate RNA effector molecule homolog (Arsenite-resistance protein 2)
length: 876
go: ENSG00000087087;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; cell proliferation [GO:0008283]; mRNA splicing, via spliceosome [GO:0000398]; neuronal stem cell population maintenance [GO:0097150]; positive regulation of neurogenesis [GO:0050769]; primary miRNA processing [GO:0031053]; regulation of transcription, DNA-templated [GO:0006355]; response to arsenic-containing substance [GO:0046685]; snRNA transcription by RNA polymerase II [GO:0042795]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=A; IsoId=Q9BXP5-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9BXP5-2; Sequence=VSP_000324; Name=3; IsoId=Q9BXP5-3; Sequence=VSP_032502; Name=4; IsoId=Q9BXP5-4; Sequence=VSP_032502, VSP_000324; Name=5; IsoId=Q9BXP5-5; Sequence=VSP_038122, VSP_038123; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent way (By similarity). {ECO:0000250}.


uniprotID: Q9Y6A9
geneSymbol: SPCS1
reactome: R-HSA-1799339;R-HSA-381771;R-HSA-400511;R-HSA-422085;
length: 102
go: ENSG00000114902;
name:
Signal peptidase complex subunit 1 (EC 3.4.-.-) (Microsomal signal peptidase 12 kDa subunit) (SPase 12 kDa subunit)

sequence:
MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSCLLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; organelle membrane [GO:0031090]; signal peptidase complex [GO:0005787]; peptidase activity [GO:0008233]; protein targeting to ER [GO:0045047]; proteolysis [GO:0006508]; signal peptide processing [GO:0006465]

location:
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q9HBM1
geneSymbol: SPC25
reactome: R-HSA-141444;R-HSA-2467813;R-HSA-2500257;R-HSA-5663220;R-HSA-68877;
pdb: 2VE7;3IZ0;
name: Kinetochore protein Spc25 (hSpc25)
length: 224
go: ENSG00000152253;
sequence:

opentargets:
condensed chromosome kinetochore [GO:0000777]; cytosol [GO:0005829]; Ndc80 complex [GO:0031262]; nucleus [GO:0005634]; cell division [GO:0051301]; chromosome segregation [GO:0007059]; mitotic spindle organization [GO:0007052]

location:
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15961401}. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14738735). Localizes specifically to the outer plate of the kinetochore (PubMed:14738735, PubMed:14699129). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735}.


uniprotID: B9EJG8
geneSymbol: TMEM150C
name: Transmembrane protein 150C
length: 249
go: ENSG00000249242;
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mechanosensitive ion channel activity [GO:0008381]; cellular response to mechanical stimulus [GO:0071260]; proprioception [GO:0019230]; regulation of autophagy [GO:0010506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=B9EJG8-1; Sequence=Displayed; Name=2; IsoId=B9EJG8-2; Sequence=VSP_039350; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000305|PubMed:25608530}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530). {ECO:0000269|PubMed:25608530}.


uniprotID: Q9NX61
geneSymbol: TMEM161A
name: Transmembrane protein 161A (Adaptive response to oxidative stress protein 29) (AROS-29)
length: 479
go: ENSG00000064545;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; cellular response to oxidative stress [GO:0034599]; cellular response to UV [GO:0034644]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902230]; positive regulation of DNA repair [GO:0045739]; response to retinoic acid [GO:0032526]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NX61-1; Sequence=Displayed; Name=2; IsoId=Q9NX61-2; Sequence=VSP_046042; Note=No experimental confirmation available.; 


uniprotID: Q9P0W8
geneSymbol: SPATA7
name: Spermatogenesis-associated protein 7 (HSD-3.1) (Spermatogenesis-associated protein HSD3)
length: 599
go: ENSG00000042317;
snps: rs4904448 rs3179969 rs35137272 rs17124662 rs17124677 rs534658921 rs10139784
sequence:

opentargets:
axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; photoreceptor connecting cilium [GO:0032391]; photoreceptor cell maintenance [GO:0045494]; protein localization to photoreceptor connecting cilium [GO:1903621]; protein localization to photoreceptor outer segment [GO:1903546]; response to stimulus [GO:0050896]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9P0W8-1; Sequence=Displayed; Name=2; IsoId=Q9P0W8-2; Sequence=VSP_008341; Note=No experimental confirmation available.; Name=3; IsoId=Q9P0W8-3; Sequence=VSP_008342; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:25398945}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25398945}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25398945}. Note=Localizes to the microtubule network (PubMed:25398945). In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). {ECO:0000250|UniProtKB:Q80VP2, ECO:0000269|PubMed:25398945}.


uniprotID: P19623
geneSymbol: SRM
reactome: R-HSA-351202;
pdb: 2O05;2O06;2O07;2O0L;3RW9;
name: Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)
length: 302
go: ENSG00000116649;
drug: DB00118;
snps: rs1049932
sequence:

opentargets:
cytosol [GO:0005829]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; spermidine synthase activity [GO:0004766]; cellular response to leukemia inhibitory factor [GO:1990830]; polyamine biosynthetic process [GO:0006596]; polyamine metabolic process [GO:0006595]; spermidine biosynthetic process [GO:0008295]


uniprotID: Q9C093
geneSymbol: SPEF2
name: Sperm flagellar protein 2 (Protein KPL2)
length: 1822
go: ENSG00000152582;
opentargets: Golgi apparatus [GO:0005794]; cell differentiation [GO:0030154]; spermatogenesis [GO:0007283]
sequence:

snps:
rs6897513 rs34307272 rs16902381 rs34852821 rs34708521 rs7710284 rs12332369 rs13170082 rs13170390 rs2277044 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9C093-1; Sequence=Displayed; Name=2; IsoId=Q9C093-2; Sequence=VSP_027524, VSP_027525; Note=No experimental confirmation available.; Name=3; IsoId=Q9C093-3; Sequence=VSP_027522, VSP_027523; Name=4; IsoId=Q9C093-4; Sequence=VSP_027521; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C9J3}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C9J3}. Note=Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells. {ECO:0000250|UniProtKB:Q8C9J3}.


uniprotID: Q5TCZ1
geneSymbol: SH3PXD2A
reactome: R-HSA-8941237;
pdb: 2DNU;2EGA;2EGC;2EKH;
length: 1133
go: ENSG00000107957;
snps: rs11818820 rs3781365 rs12764700
name:
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains)

sequence:

opentargets:
cell junction [GO:0030054]; cell projection [GO:0042995]; cytosol [GO:0005829]; podosome [GO:0002102]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; protease binding [GO:0002020]; superoxide-generating NADPH oxidase activator activity [GO:0016176]; extracellular matrix organization [GO:0030198]; osteoclast fusion [GO:0072675]; superoxide metabolic process [GO:0006801]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5TCZ1-1; Sequence=Displayed; Name=2; IsoId=Q5TCZ1-2; Sequence=VSP_023312, VSP_023313; Name=3; IsoId=Q5TCZ1-3; Sequence=VSP_023313; Note=Gene prediction based on similarity to mouse ortholog and partial transcript data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.


uniprotID: Q8N4L4
geneSymbol: SPEM1
name: Spermatid maturation protein 1
length: 309
go: ENSG00000181323;
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250}.


uniprotID: Q13148
geneSymbol: TARDBP
name: TAR DNA-binding protein 43 (TDP-43)
length: 414
go: ENSG00000120948;
pdb:
1WF0;2CQG;2N2C;2N3X;2N4G;2N4H;2N4P;4BS2;4IUF;4Y00;4Y0F;5MDI;5MRG;5W50;5W52;5W7V;5WHN;5WHP;5WIA;5WIQ;5WKB;5WKD;5X4F;6B1G;6CF4;6CFH;

sequence:

opentargets:
cytoplasm [GO:0005737]; interchromatin granule [GO:0035061]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perichromatin fibrils [GO:0005726]; ribonucleoprotein complex [GO:1990904]; distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001205]; DNA-binding transcription factor activity [GO:0003700]; double-stranded DNA binding [GO:0003690]; identical protein binding [GO:0042802]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; sequence-specific double-stranded DNA binding [GO:1990837]; single-stranded RNA binding [GO:0003727]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; mRNA processing [GO:0006397]; negative regulation by host of viral transcription [GO:0043922]; negative regulation of gene expression [GO:0010629]; negative regulation of protein phosphorylation [GO:0001933]; nuclear inner membrane organization [GO:0071765]; positive regulation of insulin secretion [GO:0032024]; regulation of apoptotic process [GO:0042981]; regulation of cell cycle [GO:0051726]; response to endoplasmic reticulum stress [GO:0034976]; RNA splicing [GO:0008380]; transcription by RNA polymerase II [GO:0006366]

snps:
rs80356715 rs80356717 rs80356718 rs80356719 rs121908395 rs80356721 rs80356721 rs80356723 rs80356723 rs4884357 rs80356726 rs80356727 rs80356728 rs80356729 rs80356730 rs80356731 rs80356733 rs80356735 rs80356739 rs80356738 rs367543041 rs80356741 rs80356742 rs80356743 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13148-1; Sequence=Displayed; Name=2; IsoId=Q13148-4; Sequence=VSP_056406, VSP_056407; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17023659, ECO:0000269|PubMed:17481916}. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.


uniprotID: Q9BR10
geneSymbol: SPATA25
name: Spermatogenesis-associated protein 25 (Testis-specific gene 23 protein)
length: 227
go: ENSG00000149634;
snps: rs3827040
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8TCT8
geneSymbol: SPPL2A
reactome: R-HSA-5357905;
length: 520
go: ENSG00000138600;
snps: rs8034443
name:
Signal peptide peptidase-like 2A (SPP-like 2A) (SPPL2a) (EC 3.4.23.-) (Intramembrane protease 3) (IMP-3) (Presenilin-like protein 2)

sequence:

opentargets:
extracellular exosome [GO:0070062]; Golgi-associated vesicle membrane [GO:0030660]; integral component of cytoplasmic side of endoplasmic reticulum membrane [GO:0071458]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:Q9JJF9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JJF9}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane.


uniprotID: Q7Z6I5
geneSymbol: SPATA12
name: Spermatogenesis-associated protein 12 (Spermatogenesis-related protein 5)
length: 190
go: ENSG00000186451;
sequence:
MSSSALTCGSTLEKSGDTWEMKALDSSRLVPWPPRGLGSSTQHPNKPHCALASCQGPGVLPGAASALPELTFQGDVCQSETCQRYLQAAISLDIAVSQINLLGRPSSPPALLIQQGSCEQVIHNSTPQFLGMEDGDNERTTGWLWRLCEDIDAEPSSTGCSRSNQLTFTEGCFVRSLSTVYSNTHIHTHL


uniprotID: Q96A44
geneSymbol: SPSB4
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 2V24;
name: SPRY domain-containing SOCS box protein 4 (SSB-4)
length: 273
go: ENSG00000175093;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; intracellular signal transduction [GO:0035556]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: O15270
geneSymbol: SPTLC2
reactome: R-HSA-1660661;
length: 562
go: ENSG00000100596;
drug: DB00133;DB00114;
snps: rs864621998 rs267607090 rs267607089 rs267607091
name:
Serine palmitoyltransferase 2 (EC 2.3.1.50) (Long chain base biosynthesis protein 2) (LCB 2) (Long chain base biosynthesis protein 2a) (LCB2a) (Serine-palmitoyl-CoA transferase 2) (SPT 2)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; serine C-palmitoyltransferase complex [GO:0017059]; pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]; ceramide biosynthetic process [GO:0046513]; positive regulation of lipophagy [GO:1904504]; sphinganine biosynthetic process [GO:0046511]; sphingolipid biosynthetic process [GO:0030148]; sphingomyelin biosynthetic process [GO:0006686]; sphingosine biosynthetic process [GO:0046512]


uniprotID: Q7Z5L4
geneSymbol: SPATA19
length: 167
go: ENSG00000166118;
snps: rs2282602
location: SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}.
name:
Spermatogenesis-associated protein 19, mitochondrial (Spermatogenic cell-specific gene 1 protein) (Spergen-1)

sequence:
MIITTWIVYILARKGVGLPFLPITSSDIDVVESEAVSVLHHWLKKTEEEASRGIKEKLSINHPSQGVREKMSTDSPPTHGQDIHVTRDVVKHHLSKSDLLANQSQEVLEERTRIQFIRWSHTRIFQVPSEMTEDIMRDRIEQVRRSISRLTDVSAQDFSMRPSSSDC

opentargets:
mitochondrial outer membrane [GO:0005741]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]


uniprotID: Q8N5C6
geneSymbol: SRBD1
name: S1 RNA-binding domain-containing protein 1
length: 995
go: ENSG00000068784;
snps: rs6544834 rs3755073 rs3755072
sequence:

opentargets:
mRNA binding [GO:0003729]; structural constituent of ribosome [GO:0003735]; nucleobase-containing compound metabolic process [GO:0006139]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N5C6-1; Sequence=Displayed; Name=2; IsoId=Q8N5C6-2; Sequence=VSP_024461; 


uniprotID: O60232
geneSymbol: SSSCA1
name: Sjoegren syndrome/scleroderma autoantigen 1 (Autoantigen p27)
length: 199
go: ENSG00000173465;
opentargets: identical protein binding [GO:0042802]; cell division [GO:0051301]; mitotic cell cycle [GO:0000278]
snps: rs35971725
sequence:
MALNGAEVDDFSWEPPTEAETKVLQARRERQDRISRLMGDYLLRGYRMLGETCADCGTILLQDKQRKIYCVACQELDSDVDKDNPALNAQAALSQAREHQLASASELPLGSRPAPQPPVPRPEHCEGAAAGLKAAQGPPAPAVPPNTDVMACTQTALLQKLTWASAELGSSTSLETSIQLCGLIRACAEALRSLQQLQH


uniprotID: O75391
geneSymbol: SPAG7
pdb: 2CPM;
name: Sperm-associated antigen 7
length: 227
go: ENSG00000091640;
opentargets: nucleus [GO:0005634]; nucleic acid binding [GO:0003676]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9UBP0
geneSymbol: SPAST
pdb: 3EAB;3VFD;
name: Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)
length: 616
go: ENSG00000021574;
sequence:

opentargets:
axon cytoplasm [GO:1904115]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum tubular network [GO:0071782]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; lipid droplet [GO:0005811]; microtubule [GO:0005874]; midbody [GO:0030496]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; spindle [GO:0005819]; alpha-tubulin binding [GO:0043014]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; beta-tubulin binding [GO:0048487]; microtubule binding [GO:0008017]; microtubule-severing ATPase activity [GO:0008568]; protein-containing complex binding [GO:0044877]; anterograde axonal transport [GO:0008089]; axonal transport of mitochondrion [GO:0019896]; axonogenesis [GO:0007409]; cytokinetic process [GO:0032506]; cytoplasmic microtubule organization [GO:0031122]; cytoskeleton-dependent cytokinesis [GO:0061640]; ER to Golgi vesicle-mediated transport [GO:0006888]; exit from mitosis [GO:0010458]; membrane fission [GO:0090148]; metabolic process [GO:0008152]; microtubule bundle formation [GO:0001578]; microtubule severing [GO:0051013]; mitotic cytokinesis [GO:0000281]; mitotic spindle disassembly [GO:0051228]; nuclear envelope reassembly [GO:0031468]; positive regulation of cytokinesis [GO:0032467]; positive regulation of microtubule depolymerization [GO:0031117]; protein hexamerization [GO:0034214]; protein homooligomerization [GO:0051260]

snps:
rs121908515 rs121908517 rs1343258361 rs372005558 rs141944844 rs773193617 rs202152835 rs121908513 rs1057519181 rs121908509 rs121908514 rs1131691977 rs797044850 rs587777757 rs1064793273 rs1060502227 rs121908512 rs121908510 rs878854990 rs121908516 rs121908511 rs878854991 rs864622162 rs864622179 rs878854992 rs121908518 rs863224923 rs144594804 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing, Alternative initiation; Named isoforms=4;  Comment=Alternative promoter usage of a cryptic promoter in exon 1 can direct the synthesis of N-terminally truncated isoforms, which may also arise from alternative initiation. {ECO:0000269|PubMed:16026783, ECO:0000269|PubMed:18613979}; Name=1; Synonyms=Long, Long variant 1, 68 kDa {ECO:0000303|PubMed:19000169}, M1 {ECO:0000303|PubMed:20200447}; IsoId=Q9UBP0-1; Sequence=Displayed; Name=2; Synonyms=Long variant 2; IsoId=Q9UBP0-2; Sequence=VSP_000024; Name=3; Synonyms=Short, Short variant 1, 60 kDa {ECO:0000303|PubMed:19000169}, M87 {ECO:0000303|PubMed:20200447}; IsoId=Q9UBP0-3; Sequence=VSP_036650; Note=Produced by alternative promoter usage. May also be produced by alternative initiation at Met-87 of isoform 1. Major isoform.; Name=4; Synonyms=Short variant 2; IsoId=Q9UBP0-4; Sequence=VSP_036650, VSP_000024; Note=Produced by alternative promoter usage and alternative splicing. May also be produced by alternative initiation at Met-87 of isoform 2.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:19000169}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000305|PubMed:20200447}. Endoplasmic reticulum {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:16602018}. Midbody {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:18997780, ECO:0000269|PubMed:21310966}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15891913}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15716377, ECO:0000269|PubMed:17389232, ECO:0000269|PubMed:18410514, ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20200447}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:11809724, ECO:0000269|PubMed:15269182, ECO:0000269|PubMed:15537668}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15147984, ECO:0000269|PubMed:16026783}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15269182}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:16026783, ECO:0000269|PubMed:20200447}. Note=Forms a intramembrane hairpin-like structure in the membrane (PubMed:20200447). Localization to the centrosome is independent of microtubules (PubMed:15891913). Localizes to the midbody of dividing cells, and this requires CHMP1B (PubMed:18997780). Enriched in the distal axons and branches of postmitotic neurons (PubMed:15269182). {ECO:0000255|HAMAP-Rule:MF_03021, ECO:0000269|PubMed:15269182, ECO:0000269|PubMed:15891913, ECO:0000269|PubMed:18997780, ECO:0000305|PubMed:20200447}.; SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:23969831}; Peripheral membrane protein {ECO:0000305|PubMed:20200447}. Nucleus membrane {ECO:0000269|PubMed:26040712}. Lipid droplet {ECO:0000269|PubMed:25875445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:20200447}. Endosome {ECO:0000269|PubMed:23897888}. Note=Forms a intramembrane hairpin-like structure in the membrane (PubMed:20200447). Recruited to nuclear membrane by IST1 during late anaphase (PubMed:26040712). Localizes to endoplasmic reticulum tubular network (PubMed:23969831). {ECO:0000269|PubMed:23969831, ECO:0000269|PubMed:26040712, ECO:0000305|PubMed:20200447}.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm {ECO:0000269|PubMed:20200447, ECO:0000269|PubMed:23969831}. Endosome {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:23897888}. Nucleus membrane {ECO:0000269|PubMed:16026783, ECO:0000269|PubMed:26040712}. Note=Constitutes the main endosomal form (PubMed:19000169). Recruited to nuclear membrane by IST1 during late anaphase (PubMed:26040712). {ECO:0000269|PubMed:19000169, ECO:0000269|PubMed:26040712}.


uniprotID: Q9BSE5
geneSymbol: AGMAT
reactome: R-HSA-351143;
name: Agmatinase, mitochondrial (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)
length: 352
go: ENSG00000116771;
snps: rs6429757 rs11580170
location: SUBCELLULAR LOCATION: Mitochondrion.
sequence:

opentargets:
mitochondrion [GO:0005739]; agmatinase activity [GO:0008783]; metal ion binding [GO:0046872]; agmatine biosynthetic process [GO:0097055]; putrescine biosynthetic process from arginine [GO:0033388]; spermidine biosynthetic process [GO:0008295]


uniprotID: Q5MJ68
geneSymbol: SPDYC
name: Speedy protein C (Rapid inducer of G2/M progression in oocytes C) (RINGO C) (hSpy/Ringo C)
length: 293
go: ENSG00000204710;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; cell cycle [GO:0007049]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20605920}. Note=Colocalizes with tubulin gamma during interphase. During mitosis, enriched at the spindle poles and the midbody during telophase.


uniprotID: Q15772
geneSymbol: SPEG
pdb: 1U2H;
length: 3267
go: ENSG00000072195;
location: SUBCELLULAR LOCATION: Isoform 3: Nucleus.
name:
Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)

sequence:

opentargets:
nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; cardiovascular system development [GO:0072358]; muscle cell differentiation [GO:0042692]; muscle organ development [GO:0007517]; negative regulation of cell proliferation [GO:0008285]

snps:
rs55821435 rs34398769 rs34861443 rs56334571 rs55670811 rs757589345 rs55916864 rs34994343 rs55646900 rs762000831 rs10755037 rs13026308 rs566841339 rs587777676 rs12464085 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;  Name=4; IsoId=Q15772-5; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q15772-3; Sequence=VSP_018259, VSP_018261, VSP_018262; Note=No experimental confirmation available.; Name=3; Synonyms=APEG1; IsoId=Q15772-4; Sequence=VSP_018258, VSP_018261, VSP_018262; Note=Produced by alternative promoter usage.; Name=1; Synonyms=SPEG; IsoId=Q15772-1; Sequence=VSP_036071; Note=Produced by alternative splicing.; 


uniprotID: Q8N0Z3
geneSymbol: SPICE1
length: 855
go: ENSG00000163611;
snps: rs16861032 rs7614751
name:
Spindle and centriole-associated protein 1 (Coiled-coil domain-containing protein 52) (Spindle and centriole-associated protein)

sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; spindle [GO:0005819]; cell division [GO:0051301]; metaphase plate congression [GO:0051310]; mitotic spindle assembly [GO:0090307]; regulation of centriole replication [GO:0046599]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:20736305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20736305}.


uniprotID: Q8NHS9
geneSymbol: SPATA22
name: Spermatogenesis-associated protein 22 (Testis development protein NYD-SP20)
length: 363
go: ENSG00000141255;
snps: rs2291604 rs1488690 rs11556563 rs1488689
sequence:

opentargets:
chromosome [GO:0005694]; gamete generation [GO:0007276]; meiotic DNA repair synthesis [GO:0000711]; synapsis [GO:0007129]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=NYD-SP20C, NYD-SP20D; IsoId=Q8NHS9-1; Sequence=Displayed; Name=2; Synonyms=NYD-SP20B; IsoId=Q8NHS9-2; Sequence=VSP_020763; Name=3; IsoId=Q8NHS9-3; Sequence=VSP_044858; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Chromosome {ECO:0000250}. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB (By similarity). {ECO:0000250}.


uniprotID: P35321
geneSymbol: SPRR1A
reactome: R-HSA-6809371;
name: Cornifin-A (19 kDa pancornulin) (SPRK) (Small proline-rich protein IA) (SPR-IA)
sequence: MNSQQQKQPCTPPPQPQQQQVKQPCQPPPQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVTPAPAQQKTKQK
length: 89
go: ENSG00000169474;
snps: rs1611762 rs1611764
location: SUBCELLULAR LOCATION: Cytoplasm.
opentargets:
cornified envelope [GO:0001533]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein binding, bridging [GO:0030674]; structural constituent of epidermis [GO:0030280]; structural molecule activity [GO:0005198]; cornification [GO:0070268]; epidermis development [GO:0008544]; keratinocyte differentiation [GO:0030216]; peptide cross-linking [GO:0018149]


uniprotID: Q5VSR9
geneSymbol: SPANXN1
sequence: MEQPTSSINGEKRKSPCESNNENDEMQETPNRDLAPEPSLKKMKTSEYSTVLAFCYRKAKKIHSNQLENDQS
length: 72
go: ENSG00000203923;
name:
Sperm protein associated with the nucleus on the X chromosome N1 (Nuclear-associated protein SPAN-Xn1) (SPANX-N1) (SPANX family member N1)


uniprotID: Q5MJ07
geneSymbol: SPANXN5
sequence: MEKPTSSTNGEKRKSPCDSNSKNDEMQETPNRDLVLEPSLKKMKTSEYSTVLVLCYRKTKKIHSNQLENDQS
length: 72
go: ENSG00000204363;
name:
Sperm protein associated with the nucleus on the X chromosome N5 (Nuclear-associated protein SPAN-Xn5) (SPANX-N5) (SPANX family member N5)


uniprotID: O43597
geneSymbol: SPRY2
reactome: R-HSA-1295596;R-HSA-182971;
pdb: 3BUM;3OB1;5HKY;5HKZ;5HL0;
name: Protein sprouty homolog 2 (Spry-2)
length: 315
go: ENSG00000136158;
snps: rs504122 rs869025336
sequence:

opentargets:
cytoskeleton [GO:0005856]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; protein serine/threonine kinase inhibitor activity [GO:0030291]; bud elongation involved in lung branching [GO:0060449]; cell fate commitment [GO:0045165]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; establishment of mitotic spindle orientation [GO:0000132]; inner ear morphogenesis [GO:0042472]; lung growth [GO:0060437]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell projection organization [GO:0031345]; negative regulation of cell proliferation [GO:0008285]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of GTPase activity [GO:0034260]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neurotrophin TRK receptor signaling pathway [GO:0051387]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of Ras protein signal transduction [GO:0046580]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; positive regulation of cell migration [GO:0030335]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of cell differentiation [GO:0045595]; sensory perception of sound [GO:0007605]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10887178}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10887178}. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).


uniprotID: Q9HD15
geneSymbol: SRA1
pdb: 2MGX;4NBO;
name: Steroid receptor RNA activator 1 (Steroid receptor RNA activator protein) (SRAP)
length: 236
go: ENSG00000213523;
snps: rs35610885
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intercellular bridge [GO:0045171]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ribonucleoprotein complex [GO:1990904]; nuclear receptor transcription coactivator activity [GO:0030374]; steroid receptor RNA activator RNA binding [GO:0002153]; transcription coactivator activity [GO:0003713]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; cellular response to estrogen stimulus [GO:0071391]; negative regulation of myoblast differentiation [GO:0045662]; regulation of apoptotic process [GO:0042981]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12565891}. Cytoplasm {ECO:0000269|PubMed:12565891}.


uniprotID: Q9NUV7
geneSymbol: SPTLC3
reactome: R-HSA-1660661;
length: 552
go: ENSG00000172296;
drug: DB00114;
snps: rs243887 rs934335
name:
Serine palmitoyltransferase 3 (EC 2.3.1.50) (Long chain base biosynthesis protein 2b) (LCB2b) (Long chain base biosynthesis protein 3) (LCB 3) (Serine-palmitoyl-CoA transferase 3) (SPT 3)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; serine C-palmitoyltransferase complex [GO:0017059]; pyridoxal phosphate binding [GO:0030170]; serine C-palmitoyltransferase activity [GO:0004758]; sphingoid biosynthetic process [GO:0046520]; sphingolipid biosynthetic process [GO:0030148]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NUV7-1; Sequence=Displayed; Name=2; IsoId=Q9NUV7-2; Sequence=VSP_028167, VSP_028168; 


uniprotID: Q96JI7
geneSymbol: SPG11
name: Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein)
length: 2443
go: ENSG00000104133;
snps: rs3759875 rs312262723 rs3759871 rs779830116 rs371334506 rs764647588
sequence:

opentargets:
axon [GO:0030424]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; synapse [GO:0045202]; axo-dendritic transport [GO:0008088]; axon extension [GO:0048675]; chemical synaptic transmission [GO:0007268]; phagosome-lysosome fusion involved in apoptotic cell clearance [GO:0090389]; synaptic vesicle transport [GO:0048489]; walking behavior [GO:0090659]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96JI7-1; Sequence=Displayed; Name=2; IsoId=Q96JI7-2; Sequence=VSP_025483, VSP_025484; Note=No experimental confirmation available.; Name=3; IsoId=Q96JI7-3; Sequence=VSP_045347; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17322883}. Nucleus {ECO:0000269|PubMed:17322883}. Cell projection, axon {ECO:0000269|PubMed:24794856}. Cell projection, dendrite {ECO:0000269|PubMed:24794856}. Note=Mainly cytoplasmic. {ECO:0000269|PubMed:17322883}.


uniprotID: Q13501
geneSymbol: SQSTM1
reactome: R-HSA-205043;R-HSA-209543;R-HSA-209560;R-HSA-5205685;R-HSA-9020702;
pdb: 1Q02;2JY7;2JY8;2K0B;2KNV;4MJS;4UF8;4UF9;5YP7;5YP8;5YPA;5YPB;5YPC;5YPE;5YPF;5YPG;5YPH;
length: 440
go: ENSG00000161011;
name:
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)

sequence:

opentargets:
aggresome [GO:0016235]; amphisome [GO:0044753]; autolysosome [GO:0044754]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; inclusion body [GO:0016234]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; Lewy body [GO:0097413]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; phagophore assembly site [GO:0000407]; PML body [GO:0016605]; sarcomere [GO:0030017]; sperm midpiece [GO:0097225]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; ionotropic glutamate receptor binding [GO:0035255]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein kinase C binding [GO:0005080]; protein serine/threonine kinase activity [GO:0004674]; receptor tyrosine kinase binding [GO:0030971]; SH2 domain binding [GO:0042169]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; aggrephagy [GO:0035973]; apoptotic process [GO:0006915]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; cell differentiation [GO:0030154]; endosomal transport [GO:0016197]; endosome organization [GO:0007032]; immune system process [GO:0002376]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; macroautophagy [GO:0016236]; mitochondrion organization [GO:0007005]; mitophagy [GO:0000423]; negative regulation of apoptotic process [GO:0043066]; negative regulation of growth of symbiont in host [GO:0044130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of long-term synaptic potentiation [GO:1900273]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein heterooligomerization [GO:0051291]; protein localization [GO:0008104]; protein localization to perinuclear region of cytoplasm [GO:1905719]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of mitochondrion organization [GO:0010821]; regulation of protein complex stability [GO:0061635]; regulation of Ras protein signal transduction [GO:0046578]; response to ischemia [GO:0002931]; response to mitochondrial depolarisation [GO:0098780]; selective autophagy [GO:0061912]; ubiquitin-dependent protein catabolic process [GO:0006511]

snps:
rs141502868 rs200396166 rs148366738 rs181263868 rs748170760 rs771903158 rs147810437 rs200152247 rs548787835 rs769325755 rs753212399 rs750256905 rs145056421 rs201263163 rs761822261 rs765200636 rs151191977 rs11548633 rs774986849 rs55793208 rs200445838 rs541356917 rs61748794 rs140226523 rs148294622 rs772889843 rs774512680 rs143956614 rs772122047 rs776749939 rs104893941 rs771966860 rs143511494 rs757212984 rs770118706 rs199854262 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13501-1; Sequence=Displayed; Name=2; IsoId=Q13501-2; Sequence=VSP_015841; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:22792322}. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Nucleus, PML body {ECO:0000269|PubMed:20168092}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Note=In cardiac muscle, localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin-containing protein aggregates (sequestosomes) and membrane-surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum. Co-localizes with TRIM5 in cytoplasmic bodies. When nuclear export is blocked by treatment with leptomycin B, accumulates in PML bodies. {ECO:0000269|PubMed:20168092}.


uniprotID: Q96GP6
geneSymbol: SCARF2
length: 870
snps: rs361566 rs2241230 rs12484828 rs759611 rs759612 rs874100 rs874101
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
Scavenger receptor class F member 2 (SRECRP-1) (Scavenger receptor expressed by endothelial cells 2 protein) (SREC-II)

sequence:

opentargets:
focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GP6-1; Sequence=Displayed; Name=2; IsoId=Q96GP6-2; Sequence=VSP_042462; 


uniprotID: Q14162
geneSymbol: SCARF1
reactome: R-HSA-3000484;
length: 830
go: ENSG00000074660;
snps: rs2272011 rs35455643 rs3744644 rs8072430 rs4790250 rs3760460
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
Scavenger receptor class F member 1 (Acetyl LDL receptor) (Scavenger receptor expressed by endothelial cells 1) (SREC-I)

sequence:

opentargets:
endocytic vesicle membrane [GO:0030666]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; low-density lipoprotein particle binding [GO:0030169]; scavenger receptor activity [GO:0005044]; transmembrane signaling receptor activity [GO:0004888]; cell adhesion [GO:0007155]; cholesterol catabolic process [GO:0006707]; dendrite development [GO:0016358]; neuron remodeling [GO:0016322]; positive regulation of axon regeneration [GO:0048680]; positive regulation of neuron projection development [GO:0010976]; receptor-mediated endocytosis [GO:0006898]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=SREC-1; IsoId=Q14162-1; Sequence=Displayed; Name=2; Synonyms=SREC-5; IsoId=Q14162-2; Sequence=VSP_039956; Name=3; Synonyms=SREC-3; IsoId=Q14162-3; Sequence=VSP_039960, VSP_039961; Name=4; Synonyms=SREC-4; IsoId=Q14162-4; Sequence=VSP_039957; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=SREC-2; IsoId=Q14162-5; Sequence=VSP_039958, VSP_039959; Note=No experimental confirmation available.; 


uniprotID: Q5H9L4
geneSymbol: TAF7L
length: 462
go: ENSG00000102387;
snps: rs5951328 rs147493489 rs35899692 rs41310729
name:
Transcription initiation factor TFIID subunit 7-like (Cancer/testis antigen 40) (CT40) (RNA polymerase II TBP-associated factor subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit)

sequence:

opentargets:
cytoplasm [GO:0005737]; transcription factor TFIID complex [GO:0005669]; histone acetyltransferase binding [GO:0035035]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; regulation of transcription by RNA polymerase II [GO:0006357]; RNA polymerase II preinitiation complex assembly [GO:0051123]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5H9L4-1; Sequence=Displayed; Name=2; IsoId=Q5H9L4-2; Sequence=VSP_028847; Note=No experimental confirmation available.; Name=3; IsoId=Q5H9L4-3; Sequence=VSP_028847, VSP_028848; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids. {ECO:0000250}.


uniprotID: Q9C0H9
geneSymbol: SRCIN1
length: 1183
go: ENSG00000277363;
name:
SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; axon [GO:0030424]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synapse [GO:0045202]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; exocytosis [GO:0006887]; negative regulation of protein secretion [GO:0050709]; negative regulation of protein tyrosine kinase activity [GO:0061099]; positive regulation of protein tyrosine kinase activity [GO:0061098]; regulation of cell migration [GO:0030334]; regulation of dendritic spine morphogenesis [GO:0061001]; substrate adhesion-dependent cell spreading [GO:0034446]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9C0H9-5; Sequence=Displayed; Name=2 {ECO:0000305}; IsoId=Q9C0H9-2; Sequence=VSP_059451, VSP_059454; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=Q9C0H9-4; Sequence=VSP_059450, VSP_059452, VSP_059453; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localized to the perinuclear region, lamellopodia, cortical actin and actin stress fibers but not to focal adhesions. Strongly expressed in axons and dendrites of the CA1 and CA3 hippocampal regions and of the dentate gyrus. Detected in both presynapses and postsynapses and in postsynaptic density fractions.


uniprotID: Q7Z572
geneSymbol: SPATA21
name: Spermatogenesis-associated protein 21
length: 469
go: ENSG00000187144;
opentargets: calcium ion binding [GO:0005509]
snps: rs12087671 rs4661746 rs525409 rs12133574
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z572-1; Sequence=Displayed; Name=2; IsoId=Q7Z572-2; Sequence=VSP_053865; Note=No experimental confirmation available.; 


uniprotID: A2A2V5
geneSymbol: SERTM1
name: Serine-rich and transmembrane domain-containing protein 1
length: 107
go: ENSG00000180440;
opentargets: integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
MSEPDTSSGFSGSVENGTFLELFPTSLSTSVDPSSGHLSNVYIYVSIFLSLLAFLLLLLIIALQRLKNIISSSSSYPEYPSDAGSSFTNLEVCSISSQRSTFSNLSS


uniprotID: Q8IW70
geneSymbol: TMEM151B
name: Transmembrane protein 151B (Transmembrane protein 193)
length: 566
go: ENSG00000178233;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IW70-1; Sequence=Displayed; Name=2; IsoId=Q8IW70-2; Sequence=VSP_028639, VSP_028640; Note=No experimental confirmation available.; 


uniprotID: P29508
geneSymbol: SERPINB3
reactome: R-HSA-6798695;
pdb: 2ZV6;4ZK0;4ZK3;
name: Serpin B3 (Protein T4-A) (Squamous cell carcinoma antigen 1) (SCCA-1)
length: 390
go: ENSG00000057149;
drug: DB03929;DB04522;
snps: rs3180227 rs1065205
sequence:

opentargets:
azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; vesicle [GO:0031982]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; protease binding [GO:0002020]; serine-type endopeptidase inhibitor activity [GO:0004867]; virus receptor activity [GO:0001618]; autocrine signaling [GO:0035425]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of JUN kinase activity [GO:0043508]; negative regulation of peptidase activity [GO:0010466]; negative regulation of proteolysis [GO:0045861]; neutrophil degranulation [GO:0043312]; paracrine signaling [GO:0038001]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of epithelial to mesenchymal transition [GO:0010718]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P29508-1; Sequence=Displayed; Name=2; Synonyms=SCCA1b; IsoId=P29508-2; Sequence=VSP_032657; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10956412, ECO:0000269|PubMed:14970861}. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.


uniprotID: A6NNV3
geneSymbol: SPDYE16
name: Putative speedy protein E16
length: 312
opentargets: protein kinase binding [GO:0019901]
sequence:


uniprotID: Q8TCT7
geneSymbol: SPPL2B
reactome: R-HSA-5357905;
length: 592
go: ENSG00000005206;
snps: rs10402284
name:
Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; centrosome [GO:0005813]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; integral component of cytoplasmic side of endoplasmic reticulum membrane [GO:0071458]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein ectodomain proteolysis [GO:0006509]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; regulation of immune response [GO:0050776]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q8TCT7-1; Sequence=Displayed; Name=2; IsoId=Q8TCT7-2; Sequence=VSP_005204; Name=4; IsoId=Q8TCT7-4; Sequence=VSP_009221, VSP_009222; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:17965014}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=targeted through the entire secretory pathway to endosomes/lysosomes (PubMed:15998642). {ECO:0000269|PubMed:15998642}.


uniprotID: Q01892
geneSymbol: SPIB
name: Transcription factor Spi-B
length: 262
go: ENSG00000269404;
snps: rs11546996
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001205]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; cell differentiation [GO:0030154]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q01892-1; Sequence=Displayed; Name=2; Synonyms=DeltaSpi-B; IsoId=Q01892-2; Sequence=VSP_001479, VSP_001480; Name=3; IsoId=Q01892-3; Sequence=VSP_045124, VSP_045125; 

location:
SUBCELLULAR LOCATION: Isoform 1: Nucleus {ECO:0000269|PubMed:12393575}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:12393575}.


uniprotID: Q9UQ90
geneSymbol: SPG7
reactome: R-HSA-8949664;
pdb: 2QZ4;
name: Paraplegin (EC 3.4.24.-) (Cell matrix adhesion regulator) (Spastic paraplegia 7 protein)
length: 795
go: ENSG00000197912;
sequence:

opentargets:
axon cytoplasm [GO:1904115]; m-AAA complex [GO:0005745]; mitochondrial inner membrane [GO:0005743]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; metalloendopeptidase activity [GO:0004222]; peptidase activity [GO:0008233]; unfolded protein binding [GO:0051082]; zinc ion binding [GO:0008270]; anterograde axonal transport [GO:0008089]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrial outer membrane permeabilization involved in programmed cell death [GO:1902686]; mitochondrion organization [GO:0007005]; nervous system development [GO:0007399]; proteolysis [GO:0006508]; regulation of mitochondrial membrane permeability [GO:0046902]

snps:
rs535030441 rs115661328 rs141659620 rs111475461 rs2292954 rs61755320 rs758338586 rs267607085 rs370852816 rs17783943 rs864622507 rs2099104 rs12960 rs121918357 rs35749032 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UQ90-1; Sequence=Displayed; Name=2; IsoId=Q9UQ90-2; Sequence=VSP_009192, VSP_009193; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:9635427}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q96N96
geneSymbol: SPATA13
name: Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)
length: 652
go: ENSG00000182957;
snps: rs7330736
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; filopodium [GO:0030175]; lamellipodium [GO:0030027]; nucleoplasm [GO:0005654]; ruffle membrane [GO:0032587]; guanyl-nucleotide exchange factor activity [GO:0005085]; identical protein binding [GO:0042802]; Rac guanyl-nucleotide exchange factor activity [GO:0030676]; cell migration [GO:0016477]; filopodium assembly [GO:0046847]; lamellipodium assembly [GO:0030032]; regulation of cell migration [GO:0030334]; regulation of Rho protein signal transduction [GO:0035023]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=ASEF-2b; IsoId=Q96N96-1; Sequence=Displayed; Name=2; Synonyms=ASEF-2a; IsoId=Q96N96-2; Sequence=VSP_041030; Name=3; IsoId=Q96N96-3; Sequence=VSP_041031; Name=4; IsoId=Q96N96-4; Sequence=VSP_041032, VSP_041034; Name=5; IsoId=Q96N96-5; Sequence=VSP_041032, VSP_041033; Name=6; IsoId=Q96N96-6; Sequence=VSP_054112; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.


uniprotID: Q96N06
geneSymbol: SPATA33
name: Spermatogenesis-associated protein 33
length: 139
go: ENSG00000167523;
opentargets: cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]
snps: rs13329897
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:
MVTHAAGARTFCEEQKKGSTYSVPKSKEKLMEKHSQEARQADRESEKPVDSLHPGAGTAKHPPPAASLEEKPDVKQKSSRKKVVVPQIIITRASNETLVSCSSSGSDQQRTIREPEDWGPYRRHRNPSTADAYNSHLKE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96N06-1; Sequence=Displayed; Name=2; IsoId=Q96N06-2; Sequence=VSP_053288; 


uniprotID: Q8NCC5
geneSymbol: SLC37A3
name: Sugar phosphate exchanger 3 (Solute carrier family 37 member 3)
length: 494
go: ENSG00000157800;
sequence:

opentargets:
cytosol [GO:0005829]; integral component of endoplasmic reticulum membrane [GO:0030176]; transmembrane transporter activity [GO:0022857]; carbohydrate transport [GO:0008643]; hexose phosphate transport [GO:0015712]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NCC5-1; Sequence=Displayed; Name=2; IsoId=Q8NCC5-2; Sequence=VSP_029114; Note=No experimental confirmation available.; Name=3; IsoId=Q8NCC5-3; Sequence=VSP_029113, VSP_029115; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q5BIV9
geneSymbol: SPRN
reactome: R-HSA-163125;
name: Shadow of prion protein (Protein shadoo)
length: 151
go: ENSG00000203772;
snps: rs2492666
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
sequence:
MNWAPATCWALLLAAAFLCDSGAAKGGRGGARGSARGGVRGGARGASRVRVRPAQRYGAPGSSLRVAAAGAAAGAAAGAAAGLAAGSGWRRAAGPGERGLEDEEDGVPGGNGTGPGIYSYRAWTSGAGPTRGPRLCLVLGGALGALGLLRP

opentargets:
anchored component of membrane [GO:0031225]; cytosol [GO:0005829]; extracellular region [GO:0005576]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; nucleic acid binding [GO:0003676]; protein import into nucleus [GO:0006606]


uniprotID: P37108
geneSymbol: SRP14
reactome: R-HSA-1799339;R-HSA-6798695;
pdb: 1E8O;1E8S;1RY1;4UYJ;4UYK;5AOX;
name: Signal recognition particle 14 kDa protein (SRP14) (18 kDa Alu RNA-binding protein)
length: 136
go: ENSG00000140319;
snps: rs1802601 rs1802600 rs7535 rs200831083 rs16924521 rs4814
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:
MVLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGRTKPIPKKGTVEGFEPADNKCLLRATDGKKKISTVVSSKEVNKFQMAYSNLLRANMDGLKKRDKKNKTKKTKAAAAAAAAAPAAAATAPTTAATTAATAAQ

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; nucleus [GO:0005634]; secretory granule lumen [GO:0034774]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; RNA binding [GO:0003723]; cotranslational protein targeting to membrane [GO:0006613]; neutrophil degranulation [GO:0043312]; protein targeting to ER [GO:0045047]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]


uniprotID: Q9BWW4
geneSymbol: SSBP3
name: Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)
length: 388
go: ENSG00000157216;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; protein-containing complex [GO:0032991]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; head development [GO:0060322]; head morphogenesis [GO:0060323]; hematopoietic progenitor cell differentiation [GO:0002244]; midbrain-hindbrain boundary initiation [GO:0021547]; positive regulation of anterior head development [GO:2000744]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prechordal plate formation [GO:0021501]; protein-containing complex assembly [GO:0065003]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BWW4-1; Sequence=Displayed; Name=2; IsoId=Q9BWW4-2; Sequence=VSP_006260; Name=3; IsoId=Q9BWW4-3; Sequence=VSP_006261; 


uniprotID: Q9UH36
geneSymbol: SRRD
name: SRR1-like protein (SRR1 domain-containing protein)
length: 339
go: ENSG00000100104;
snps: rs4820682
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; circadian rhythm [GO:0007623]; microtubule-based process [GO:0007017]


uniprotID: Q8N0X2
geneSymbol: SPAG16
name: Sperm-associated antigen 16 protein (Pf20 protein homolog)
length: 631
go: ENSG00000144451;
snps: rs10167688 rs2042791 rs12623569
sequence:

opentargets:
axonemal central apparatus [GO:1990716]; axoneme [GO:0005930]; sperm flagellum [GO:0036126]; axoneme assembly [GO:0035082]; cilium assembly [GO:0060271]; sperm axoneme assembly [GO:0007288]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=PF20 variant 1a; IsoId=Q8N0X2-1; Sequence=Displayed; Name=2; IsoId=Q8N0X2-2; Sequence=VSP_013494, VSP_013495, VSP_013502; Note=No experimental confirmation available.; Name=3; IsoId=Q8N0X2-3; Sequence=VSP_013493, VSP_013498, VSP_013499; Note=No experimental confirmation available.; Name=4; Synonyms=PF20 variant 2a; IsoId=Q8N0X2-4; Sequence=VSP_013496, VSP_013497; Name=5; IsoId=Q8N0X2-5; Sequence=VSP_013500, VSP_013501; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K450}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q8K450}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q8K450}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8K450}. Note=Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). {ECO:0000250|UniProtKB:Q8K450}.


uniprotID: Q8IUH8
geneSymbol: SPPL2C
length: 684
go: ENSG00000185294;
snps: rs17763658 rs242944 rs12185233 rs12185268 rs12373123 rs12373139 rs17852270 rs12373142 rs16940694
name:
Signal peptide peptidase-like 2C (SPP-like 2C) (SPPL2c) (EC 3.4.23.-) (Intramembrane protease 5) (IMP-5)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi-associated vesicle membrane [GO:0030660]; integral component of cytoplasmic side of endoplasmic reticulum membrane [GO:0071458]; integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556]; lysosomal membrane [GO:0005765]; aspartic endopeptidase activity, intramembrane cleaving [GO:0042500]; protein homodimerization activity [GO:0042803]; membrane protein proteolysis [GO:0033619]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:15385547, ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}.


uniprotID: Q9Y5K1
geneSymbol: SPO11
reactome: R-HSA-912446;
name: Meiotic recombination protein SPO11 (EC 5.99.1.3) (Cancer/testis antigen 35) (CT35)
length: 396
go: ENSG00000054796;
snps: rs28368062 rs3736832 rs17406460 rs28368082
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
chromosome, telomeric region [GO:0000781]; nuclear chromosome [GO:0000228]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA topoisomerase type II (ATP-hydrolyzing) activity [GO:0003918]; endodeoxyribonuclease activity, producing 3'-phosphomonoesters [GO:0016889]; metal ion binding [GO:0046872]; DNA catabolic process, endonucleolytic [GO:0000737]; double-strand break repair involved in meiotic recombination [GO:1990918]; female gamete generation [GO:0007292]; male meiosis I [GO:0007141]; meiotic DNA double-strand break formation [GO:0042138]; meiotic DNA double-strand break processing [GO:0000706]; meiotic telomere clustering [GO:0045141]; oogenesis [GO:0048477]; ovarian follicle development [GO:0001541]; protein localization to chromosome [GO:0034502]; reciprocal meiotic recombination [GO:0007131]; spermatid development [GO:0007286]; spermatogenesis [GO:0007283]; synaptonemal complex assembly [GO:0007130]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y5K1-1; Sequence=Displayed; Name=2; IsoId=Q9Y5K1-2; Sequence=VSP_006533; Note=No experimental confirmation available.; 


uniprotID: Q7Z699
geneSymbol: SPRED1
reactome: R-HSA-5658442;R-HSA-5658623;R-HSA-6802949;
pdb: 3SYX;
name: Sprouty-related, EVH1 domain-containing protein 1 (Spred-1) (hSpred1)
length: 444
go: ENSG00000166068;
snps: rs121434318
sequence:

opentargets:
caveola [GO:0005901]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; phosphatase binding [GO:0019902]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; stem cell factor receptor binding [GO:0005173]; fibroblast growth factor receptor signaling pathway [GO:0008543]; inactivation of MAPK activity [GO:0000188]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of peptidyl-threonine phosphorylation [GO:0010801]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of protein kinase activity [GO:0006469]; positive regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043517]; regulation of MAPK cascade [GO:0043408]; regulation of protein deacetylation [GO:0090311]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Membrane, caveola {ECO:0000269|PubMed:16115197}; Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Nucleus {ECO:0000269|PubMed:16115197}. Note=Localized in cholesterol-rich membrane raft/caveola fractions.


uniprotID: P35270
geneSymbol: SPR
reactome: R-HSA-1474151;R-HSA-203615;
pdb: 1Z6Z;4HWK;4J7U;4J7X;4XWY;4Z3K;
name: Sepiapterin reductase (SPR) (EC 1.1.1.153)
length: 261
go: ENSG00000116096;
drug: DB03461;DB03886;DB04275;DB02637;
snps: rs104893665 rs104893666
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; aldo-keto reductase (NADP) activity [GO:0004033]; NADP binding [GO:0050661]; sepiapterin reductase activity [GO:0004757]; cofactor metabolic process [GO:0051186]; nitric oxide biosynthetic process [GO:0006809]; oxidation-reduction process [GO:0055114]; regulation of nitric-oxide synthase activity [GO:0050999]; tetrahydrobiopterin biosynthetic process [GO:0006729]


uniprotID: Q96BD6
geneSymbol: SPSB1
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 2JK9;3F2O;
name: SPRY domain-containing SOCS box protein 1 (SSB-1)
length: 273
go: ENSG00000171621;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q5MJ09
geneSymbol: SPANXN3
length: 141
snps: rs6654212 rs5953851
name:
Sperm protein associated with the nucleus on the X chromosome N3 (Nuclear-associated protein SPAN-Xn3) (SPANX-N3) (SPANX family member N3)

sequence:
MEQPTSSTNGEKTKSPCESNNKKNDEMQEVPNRVLAPEQSLKKTKTSEYPIIFVYYLRKGKKINSNQLENEQSQENSINPIQKEEDEGVDLSEGSSNEDEDLGPCEGPSKEDKDLDSSEGSSQEDEDLGLSEGSSQDSGED


uniprotID: Q07955
geneSymbol: SRSF1
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72165;R-HSA-72187;
pdb: 1X4A;2M7S;2M8D;2O3D;3BEG;4C0O;
length: 248
go: ENSG00000136450;
name:
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA topoisomerase binding [GO:0044547]; mRNA binding [GO:0003729]; protein kinase B binding [GO:0043422]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; alternative mRNA splicing, via spliceosome [GO:0000380]; cardiac muscle contraction [GO:0060048]; in utero embryonic development [GO:0001701]; liver regeneration [GO:0097421]; mRNA 3'-end processing [GO:0031124]; mRNA 5'-splice site recognition [GO:0000395]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; oligodendrocyte differentiation [GO:0048709]; positive regulation of RNA splicing [GO:0033120]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA export from nucleus [GO:0006405]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=ASF-1; IsoId=Q07955-1; Sequence=Displayed; Name=ASF-2; IsoId=Q07955-2; Sequence=VSP_005856; Name=ASF-3; IsoId=Q07955-3; Sequence=VSP_005857, VSP_005858; Note=May be due to intron retention.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:9420331}. Nucleus speckle {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:9420331}. Note=In nuclear speckles. Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:12215544, ECO:0000269|PubMed:20308322, ECO:0000269|PubMed:9420331}.


uniprotID: Q9UI15
geneSymbol: TAGLN3
name: Transgelin-3 (Neuronal protein 22) (NP22) (Neuronal protein NP25)
length: 199
go: ENSG00000144834;
sequence:
MANRGPSYGLSREVQEKIEQKYDADLENKLVDWIILQCAEDIEHPPPGRAHFQKWLMDGTVLCKLINSLYPPGQEPIPKISESKMAFKQMEQISQFLKAAETYGVRTTDIFQTVDLWEGKDMAAVQRTLMALGSVAVTKDDGCYRGEPSWFHRKAQQNRRGFSEEQLRQGQNVIGLQMGSNKGASQAGMTGYGMPRQIM

opentargets:
myelin sheath [GO:0043209]; nucleus [GO:0005634]; actin filament binding [GO:0051015]; central nervous system development [GO:0007417]; negative regulation of transcription by RNA polymerase II [GO:0000122]


uniprotID: Q8WXF0
geneSymbol: SRSF12
length: 261
go: ENSG00000154548;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)

sequence:

opentargets:
nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; RS domain binding [GO:0050733]; unfolded protein binding [GO:0051082]; mRNA 5'-splice site recognition [GO:0000395]; mRNA cis splicing, via spliceosome [GO:0045292]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; spliceosomal tri-snRNP complex assembly [GO:0000244]


uniprotID: Q9HBF5
geneSymbol: ST20
name: Suppressor of tumorigenicity 20 protein (Human cervical cancer suppressor gene 1 protein) (HCCS-1)
sequence: MARSRLTATSVSQVQENGFVKKLEPKSGWMTFLEVTGKICEMLFCPEAILLTRKDTPYCETGLIFLTLTKTIANTYFYF
length: 79
go: ENSG00000180953;
snps: rs7257
opentargets:
cysteine-type endopeptidase activator activity involved in apoptotic process [GO:0008656]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic signaling pathway [GO:0097190]; cellular response to UV-C [GO:0071494]; negative regulation of cell growth [GO:0030308]; positive regulation of apoptotic DNA fragmentation [GO:1902512]


uniprotID: Q9UJW9
geneSymbol: SERTAD3
length: 196
go: ENSG00000167565;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10982866}.
name:
SERTA domain-containing protein 3 (Replication protein-binding trans-activator) (RPA-binding trans-activator)

sequence:
MVGGLKRKHSDLEEEEERWEWSPAGLQSYQQALLRISLDKVQRSLGPRAPSLRRHVLIHNTLQQLQAALRLAPAPALPPEPLFLGEEDFSLSATIGSILRELDTSMDGTEPPQNPVTPLGLQNEVPPQPDPVFLEALSSRYLGDSGLDDFFLDIDTSAVEKEPARAPPEPPHNLFCAPGSWEWNELDHIMEIILGS

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; negative regulation of cell growth [GO:0030308]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: O00204
geneSymbol: SULT2B1
reactome: R-HSA-156584;
pdb: 1Q1Q;1Q1Z;1Q20;1Q22;
length: 365
go: ENSG00000088002;
drug: DB01812;DB03309;DB01708;DB02789;
snps: rs16982149 rs1114167424 rs2302947 rs762765702 rs17842463
name:
Sulfotransferase family cytosolic 2B member 1 (ST2B1) (Sulfotransferase 2B1) (EC 2.8.2.2) (Alcohol sulfotransferase) (Hydroxysteroid sulfotransferase 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; alcohol sulfotransferase activity [GO:0004027]; cholesterol binding [GO:0015485]; nucleic acid binding [GO:0003676]; steroid hormone binding [GO:1990239]; steroid sulfotransferase activity [GO:0050294]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; cholesterol metabolic process [GO:0008203]; negative regulation of cell proliferation [GO:0008285]; positive regulation of epidermal cell differentiation [GO:0045606]; steroid metabolic process [GO:0008202]; sulfate assimilation [GO:0000103]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=SULT2B1b, B; IsoId=O00204-1; Sequence=Displayed; Name=2; Synonyms=SULT2B1a, A; IsoId=O00204-2; Sequence=VSP_012510; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Microsome. Nucleus. Cytoplasm, cytosol {ECO:0000269|PubMed:28575648}. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus.


uniprotID: O75886
geneSymbol: STAM2
reactome: R-HSA-182971;R-HSA-5689880;R-HSA-6807004;R-HSA-8856825;R-HSA-8856828;R-HSA-8875360;R-HSA-917729;
pdb: 1X2Q;1X5B;2L0T;5CRV;5IXF;
name: Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein)
length: 525
go: ENSG00000115145;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; ESCRT-0 complex [GO:0033565]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; endosomal transport [GO:0016197]; intracellular protein transport [GO:0006886]; macroautophagy [GO:0016236]; membrane organization [GO:0061024]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor receptor signaling pathway [GO:0042059]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=STAM2A; IsoId=O75886-1; Sequence=Displayed; Name=2; Synonyms=STAM2B; IsoId=O75886-2; Sequence=VSP_014848; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}.


uniprotID: O76061
geneSymbol: STC2
reactome: R-HSA-381426;R-HSA-8957275;
name: Stanniocalcin-2 (STC-2) (Stanniocalcin-related protein) (STC-related protein) (STCRP)
length: 302
go: ENSG00000113739;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; enzyme binding [GO:0019899]; heme binding [GO:0020037]; hormone activity [GO:0005179]; protein homodimerization activity [GO:0042803]; cellular calcium ion homeostasis [GO:0006874]; cellular protein metabolic process [GO:0044267]; cellular response to hypoxia [GO:0071456]; decidualization [GO:0046697]; embryo implantation [GO:0007566]; endoplasmic reticulum unfolded protein response [GO:0030968]; negative regulation of gene expression [GO:0010629]; negative regulation of multicellular organism growth [GO:0040015]; post-translational protein modification [GO:0043687]; regulation of hormone biosynthetic process [GO:0046885]; regulation of store-operated calcium entry [GO:2001256]; response to oxidative stress [GO:0006979]; response to peptide hormone [GO:0043434]; response to vitamin D [GO:0033280]


uniprotID: H3BQB6
geneSymbol: STMND1
name: Stathmin domain-containing protein 1
length: 276
go: ENSG00000230873;
sequence:

opentargets:
cytoplasm [GO:0005737]; neuron projection [GO:0043005]; tubulin binding [GO:0015631]; microtubule depolymerization [GO:0007019]; neuron projection development [GO:0031175]; regulation of cytoskeleton organization [GO:0051493]; regulation of microtubule polymerization or depolymerization [GO:0031110]


uniprotID: Q8TAV4
geneSymbol: STOML3
reactome: R-HSA-2672351;
name: Stomatin-like protein 3 (SLP-3)
length: 291
go: ENSG00000133115;
sequence:

opentargets:
cilium [GO:0005929]; integral component of membrane [GO:0016021]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; ion transmembrane transport [GO:0034220]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TAV4-1; Sequence=Displayed; Name=2; IsoId=Q8TAV4-2; Sequence=VSP_042937; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6PE84}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q6PE84}. Note=Detected in lipid rafts. {ECO:0000250|UniProtKB:Q6PE84}.


uniprotID: Q6ZMD2
geneSymbol: SPNS3
name: Protein spinster homolog 3
length: 512
go: ENSG00000182557;
snps: rs34457931 rs11655342 rs368604785
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; lipid transport [GO:0006869]; transmembrane transport [GO:0055085]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZMD2-1; Sequence=Displayed; Name=2; IsoId=Q6ZMD2-2; Sequence=VSP_028197, VSP_028198; 


uniprotID: O43278
geneSymbol: SPINT1
reactome: R-HSA-6806942;R-HSA-8852405;
pdb: 1YC0;2MSX;4ISL;4ISN;4ISO;5EZD;5H7V;
name: Kunitz-type protease inhibitor 1 (Hepatocyte growth factor activator inhibitor type 1) (HAI-1)
length: 529
go: ENSG00000166145;
snps: rs11549915 rs12323939 rs7165897
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; plasma membrane [GO:0005886]; serine-type endopeptidase inhibitor activity [GO:0004867]; branching involved in labyrinthine layer morphogenesis [GO:0060670]; cellular response to BMP stimulus [GO:0071773]; extracellular matrix organization [GO:0030198]; negative regulation of neural precursor cell proliferation [GO:2000178]; neural tube closure [GO:0001843]; placenta blood vessel development [GO:0060674]; positive regulation of glial cell differentiation [GO:0045687]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=HAI-1B; IsoId=O43278-1; Sequence=Displayed; Name=2; Synonyms=HAI-1A; IsoId=O43278-2; Sequence=VSP_013019; 


uniprotID: A0A1B0GUW6
geneSymbol: SPEM3
name: Uncharacterized protein SPEM3
length: 1196
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; flagellated sperm motility [GO:0030317]; sperm individualization [GO:0007291]; spermatogenesis [GO:0007283]


uniprotID: Q8N9U9
geneSymbol: SPANXA2-OT1
name: Putative uncharacterized protein SPANXA2-OT1
length: 137
sequence:
MASPFGRLTDQKGRGHPAGSGGVEVNGGSARAAFSGGGRRVLSGGGRTAFGGGGRTAFGDGGRTAFGVGGRTAFGGGGRTAFGGGGRTAFGVGGRTAFGGGERVSLLSPGWSALARSWLTASSASRVQAILLPQPPE


uniprotID: Q13103
geneSymbol: SPP2
reactome: R-HSA-114608;R-HSA-381426;R-HSA-8957275;
name: Secreted phosphoprotein 24 (Spp-24) (Secreted phosphoprotein 2)
length: 211
go: ENSG00000072080;
snps: rs34347825
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; extracellular region [GO:0005576]; platelet dense granule lumen [GO:0031089]; endopeptidase inhibitor activity [GO:0004866]; bone remodeling [GO:0046849]; cellular protein metabolic process [GO:0044267]; platelet degranulation [GO:0002576]; post-translational protein modification [GO:0043687]; skeletal system development [GO:0001501]


uniprotID: Q6PJ21
geneSymbol: SPSB3
reactome: R-HSA-8951664;
name: SPRY domain-containing SOCS box protein 3 (SSB-3)
length: 355
go: ENSG00000162032;
snps: rs35816944
sequence:

opentargets:
cytosol [GO:0005829]; SCF ubiquitin ligase complex [GO:0019005]; ubiquitin-protein transferase activity [GO:0004842]; post-translational protein modification [GO:0043687]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q9UHB9
geneSymbol: SRP68
reactome: R-HSA-1799339;
pdb: 4P3E;4P3F;5M72;5M73;5WRV;
name: Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)
length: 627
go: ENSG00000167881;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus.
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; ribosome [GO:0005840]; signal recognition particle [GO:0048500]; signal recognition particle, endoplasmic reticulum targeting [GO:0005786]; 7S RNA binding [GO:0008312]; endoplasmic reticulum signal peptide binding [GO:0030942]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; signal recognition particle binding [GO:0005047]; response to drug [GO:0042493]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UHB9-1; Sequence=Displayed; Name=2; IsoId=Q9UHB9-2; Sequence=VSP_008347; Note=No experimental confirmation available.; Name=3; IsoId=Q9UHB9-3; Sequence=VSP_045132; Name=4; IsoId=Q9UHB9-4; Sequence=VSP_046944; Note=No experimental confirmation available.; 


uniprotID: Q13242
geneSymbol: SRSF9
reactome: R-HSA-109688;R-HSA-159236;R-HSA-72163;R-HSA-72187;
length: 221
go: ENSG00000111786;
name:
Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; protein domain specific binding [GO:0019904]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA cis splicing, via spliceosome [GO:0045292]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splice site selection [GO:0006376]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; response to alkaloid [GO:0043279]; response to toxic substance [GO:0009636]; RNA export from nucleus [GO:0006405]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11694584, ECO:0000269|PubMed:12024014, ECO:0000269|PubMed:12604611}. Note=Cellular stresses such as heat shock may induce localization to discrete nuclear bodies termed SAM68 nuclear bodies (SNBs), HAP bodies, or stress bodies. Numerous splicing factors including SRSF1/SFRS1/SF2, SRSF7/SFRS7, SAFB and KHDRBS1/SAM68 accumulate at these structures, which may participate in the post-transcriptional regulation of mRNAs in stressed cells.


uniprotID: P17542
geneSymbol: TAL1
reactome: R-HSA-8939236;
pdb: 2YPA;2YPB;
length: 331
go: ENSG00000162367;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
name:
T-cell acute lymphocytic leukemia protein 1 (TAL-1) (Class A basic helix-loop-helix protein 17) (bHLHa17) (Stem cell protein) (T-cell leukemia/lymphoma protein 5)

sequence:

opentargets:
nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; E-box binding [GO:0070888]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein heterodimerization activity [GO:0046982]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; RNA polymerase II transcription factor binding [GO:0001085]; transcription regulatory region DNA binding [GO:0044212]; angiogenesis [GO:0001525]; astrocyte fate commitment [GO:0060018]; basophil differentiation [GO:0030221]; cell fate commitment [GO:0045165]; definitive hemopoiesis [GO:0060216]; embryonic hemopoiesis [GO:0035162]; erythrocyte differentiation [GO:0030218]; erythrocyte maturation [GO:0043249]; hemangioblast cell differentiation [GO:0060217]; hematopoietic stem cell differentiation [GO:0060218]; hemopoiesis [GO:0030097]; locomotory behavior [GO:0007626]; megakaryocyte development [GO:0035855]; megakaryocyte differentiation [GO:0030219]; negative regulation of erythrocyte differentiation [GO:0045647]; negative regulation of transcription by RNA polymerase II [GO:0000122]; platelet formation [GO:0030220]; positive regulation of cell division [GO:0051781]; positive regulation of chromatin assembly or disassembly [GO:0045799]; positive regulation of erythrocyte differentiation [GO:0045648]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of signaling receptor activity [GO:2000273]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell proliferation [GO:0042127]; regulation of hematopoietic stem cell differentiation [GO:1902036]; regulation of mast cell differentiation [GO:0060375]; regulation of stem cell population maintenance [GO:2000036]; regulation of transcription by RNA polymerase II [GO:0006357]; spinal cord association neuron differentiation [GO:0021527]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=The splicing pattern is cell-lineage dependent.; Name=PP42-TAL1; IsoId=P17542-1; Sequence=Displayed; Name=PP39-TAL1; IsoId=P17542-2; Sequence=VSP_002153; Name=PP22-TAL1; IsoId=P17542-3; Sequence=VSP_002154; 


uniprotID: Q86UX6
geneSymbol: STK32C
name: Serine/threonine-protein kinase 32C (EC 2.7.11.1) (PKE) (Yet another novel kinase 3)
length: 486
go: ENSG00000165752;
snps: rs17854384 rs764558009 rs56109103 rs55812591
sequence:

opentargets:
intracellular [GO:0005622]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86UX6-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=Q86UX6-2; Sequence=VSP_051998; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: P0CL83
geneSymbol: STAG3L1
name: Putative STAG3-like protein 1 (Stromal antigen 3-like protein 1)
length: 205
opentargets: nucleus [GO:0005634]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}.
sequence:


uniprotID: P50225
geneSymbol: SULT1A1
reactome: R-HSA-156584;
pdb: 1LS6;1Z28;2D06;3QVU;3QVV;3U3J;3U3K;3U3M;3U3O;3U3R;4GRA;
length: 295
go: ENSG00000196502;
drug: DB00316;DB01812;DB04417;DB00675;
snps: rs72547527 rs1042014 rs1042011 rs1042028 rs1801030 rs35728980 rs36043491
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)

sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; flavonol 3-sulfotransferase activity [GO:0047894]; steroid sulfotransferase activity [GO:0050294]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; amine metabolic process [GO:0009308]; catecholamine metabolic process [GO:0006584]; estrogen metabolic process [GO:0008210]; ethanol catabolic process [GO:0006068]; flavonoid metabolic process [GO:0009812]; sulfation [GO:0051923]; xenobiotic metabolic process [GO:0006805]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P50225-1; Sequence=Displayed; Name=2; IsoId=P50225-2; Sequence=VSP_040101; Note=No experimental confirmation available.; 


uniprotID: Q6ZMT1
geneSymbol: STAC2
pdb: 6B26;6B27;6B28;
length: 411
go: ENSG00000141750;
name:
SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2)

sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; sarcolemma [GO:0042383]; metal ion binding [GO:0046872]; intracellular signal transduction [GO:0035556]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of voltage-gated calcium channel activity [GO:1901387]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZMT1-1; Sequence=Displayed; Name=2; IsoId=Q6ZMT1-2; Sequence=VSP_022742; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Note=Colocalizes with CACNA1C at the plasma membrane of transfected cells. {ECO:0000250|UniProtKB:Q8R1B0}.


uniprotID: O75897
geneSymbol: SULT1C4
reactome: R-HSA-156584;
pdb: 2AD1;2GWH;
name: Sulfotransferase 1C4 (ST1C4) (EC 2.8.2.-) (Sulfotransferase 1C2) (SULT1C#2)
length: 302
go: ENSG00000198075;
snps: rs1402467 rs41322445
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
cytosol [GO:0005829]; aryl sulfotransferase activity [GO:0004062]; sulfotransferase activity [GO:0008146]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; ethanol catabolic process [GO:0006068]; sulfation [GO:0051923]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75897-1; Sequence=Displayed; Name=2; IsoId=O75897-2; Sequence=VSP_056255; 


uniprotID: P36952
geneSymbol: SERPINB5
pdb: 1WZ9;1XQG;1XQJ;1XU8;
name: Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5)
length: 375
go: ENSG00000206075;
snps: rs2289519 rs2289520 rs1455555
location: SUBCELLULAR LOCATION: Secreted, extracellular space.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; extracellular matrix organization [GO:0030198]; morphogenesis of an epithelium [GO:0002009]; negative regulation of endopeptidase activity [GO:0010951]; prostate gland morphogenesis [GO:0060512]; regulation of epithelial cell proliferation [GO:0050678]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P36952-1; Sequence=Displayed; Name=2; IsoId=P36952-2; Sequence=VSP_037145, VSP_037146; 


uniprotID: Q8IY81
geneSymbol: FTSJ3
reactome: R-HSA-6791226;
length: 847
go: ENSG00000108592;
snps: rs2584625 rs2727288
name:
pre-rRNA processing protein FTSJ3 (EC 2.1.1.-) (2'-O-ribose RNA methyltransferase SPB1 homolog) (Protein ftsJ homolog 3) (Putative rRNA methyltransferase 3)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]; RNA binding [GO:0003723]; rRNA (guanine) methyltransferase activity [GO:0016435]; rRNA (uridine-2'-O-)-methyltransferase activity [GO:0008650]; enzyme-directed rRNA 2'-O-methylation [GO:0000453]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; rRNA methylation [GO:0031167]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03163, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22195017}.


uniprotID: P50452
geneSymbol: SERPINB8
reactome: R-HSA-75205;
name: Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)
length: 374
go: ENSG00000166401;
snps: rs1944270 rs1648493 rs3169983 rs3826616
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; epithelial cell-cell adhesion [GO:0090136]; negative regulation of endopeptidase activity [GO:0010951]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P50452-1; Sequence=Displayed; Name=2; IsoId=P50452-2; Sequence=VSP_043097; Note=No experimental confirmation available.; Name=3; IsoId=P50452-3; Sequence=VSP_055135; 


