# reactome

reactomeID: 141405
pathwayName:
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components


reactomeID: 1362300
pathwayName:
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1


reactomeID: 1226095
pathwayName:
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex


reactomeID: 1226094
pathwayName:
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex


reactomeID: 68913
pathwayName:
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin


reactomeID: 68950
pathwayName:
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin


reactomeID: 2314569
pathwayName:
GOLGA2 phosphorylated by CDK1 is unable to promote fusion of ER to Golgi transport vesicles with cis-Golgi


reactomeID: 2314566
pathwayName:
GORASP1 phosphorylated by PLK1 and GORASP2 phosphorylated by MAPK3-3/MAPK1 are unable to promote Golgi cisternae stacking


reactomeID: 179419
pathwayName:
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint


reactomeID: 174238
pathwayName:
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1


reactomeID: 174178
pathwayName:
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1


reactomeID: 164620
pathwayName:
Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End


reactomeID: 174425
pathwayName:
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere


reactomeID: 174427
pathwayName:
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere


reactomeID: 176700
pathwayName:
Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure


reactomeID: 9023943
pathwayName:
MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end


reactomeID: 3223236
pathwayName:
RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS)


reactomeID: 3223200
pathwayName:
Demethylation of H3K27Me3 by KDM6B stimulates p16-INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16-INK4A transcription


reactomeID: 4827382
pathwayName:
SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)


reactomeID: 5651654
pathwayName:
SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)


reactomeID: 210744
pathwayName:
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells


reactomeID: 1181156
pathwayName:
Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL


reactomeID: 1225894
pathwayName:
Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL


reactomeID: 189053
pathwayName:
Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose


reactomeID: 1225951
pathwayName:
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)


reactomeID: 1225957
pathwayName:
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)


reactomeID: 1226012
pathwayName:
Binding of PI3K p110 subunit alpha (PIK3CA) to complex of GRB2:GAB1:PIK3R1 and ligand-responsive p-6Y-EGFR mutants


reactomeID: 1220610
pathwayName:
Non-covalent tyrosine kinase inhibitors bind and inactivate sensitive ligand-responsive EGFR cancer mutants


reactomeID: 1220611
pathwayName:
Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors


reactomeID: 5637808
pathwayName:
SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)


reactomeID: 4839743
pathwayName:
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex


reactomeID: 5678771
pathwayName:
Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1


reactomeID: 5678520
pathwayName:
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2


reactomeID: 5678420
pathwayName:
Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia


reactomeID: 5683209
pathwayName:
Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM).


reactomeID: 5625015
pathwayName:
Defective SLC1A3 does not cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol


reactomeID: 5619050
pathwayName:
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4),  distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)


reactomeID: 5619054
pathwayName:
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)


reactomeID: 5659734
pathwayName:
Defective SLC6A19 does not cotransport neutral amino acids, Na+ from extracellular region to cytosol


reactomeID: 5579015
pathwayName:
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)


reactomeID: 5579013
pathwayName:
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)


reactomeID: 5688031
pathwayName:
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)


reactomeID: 5688354
pathwayName:
Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)


reactomeID: 4686998
pathwayName:
Defective MPDU1 does not promote transfer of Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1 by ALG12


reactomeID: 167130
pathwayName:
Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP


reactomeID: 184269
pathwayName:
Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex


reactomeID: 200952
pathwayName:
Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction


reactomeID: 168874
pathwayName:
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus


reactomeID: 168869
pathwayName:
Budding of vesicle with the HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum into the cytosol


reactomeID: 110172
pathwayName:
MBD4 glycosylase mediated recognition and binding of a thymine opposite to a guanine at CpG sequences


reactomeID: 110171
pathwayName:
MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences


reactomeID: 5649723
pathwayName:
POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution


reactomeID: 5652005
pathwayName:
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA


reactomeID: 5693565
pathwayName:
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


reactomeID: 5685985
pathwayName:
EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment


reactomeID: 68849
pathwayName:
Mcm2-7 associates with the Cdt1:CDC6:ORC:origin complex, forming the pre-replicative complex (preRC)


reactomeID: 2396337
pathwayName:
HSPG2 binds FGF2(10-155), Fibronectn matrix, Transthyretin tetramer, PDGFA homodimer, PDGFB homodimer


reactomeID: 2681667
pathwayName:
TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1


reactomeID: 74993
pathwayName:
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box


reactomeID: 6803205
pathwayName:
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain


reactomeID: 6804115
pathwayName:
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain


reactomeID: 8935785
pathwayName:
RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675


reactomeID: 8935731
pathwayName:
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6


reactomeID: 8936628
pathwayName:
GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6


reactomeID: 8936995
pathwayName:
THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6


reactomeID: 8937097
pathwayName:
MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6


reactomeID: 8939900
pathwayName:
RUNX2 gene expression from proximal (P2) promoter is stimulated by ESR1:estrogen, ESRRA:PPARG1CA, TWIST1 and RUNX2-P2, and inhibited by ESRRA:PPARG1CB and DEXA:NR3C1


reactomeID: 9007686
pathwayName:
RUNX2 gene expression from distal (P1) promoter is inhibited by NKX3-2, MSX2 and RUNX2-P1, and stimulated by DLX5,(DLX6)


reactomeID: 109638
pathwayName:
Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex


reactomeID: 6807496
pathwayName:
POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)


reactomeID: 6810238
pathwayName:
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)


reactomeID: 6810233
pathwayName:
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter


reactomeID: 6810235
pathwayName:
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain


reactomeID: 5629218
pathwayName:
HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1


reactomeID: 5601929
pathwayName:
Unknown nuclease cleaves cleaved transposon RNA in 6xMeR-PIWIL2:cleaved transposon RNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1


reactomeID: 5601919
pathwayName:
Unknown nuclease cleaves cleaved transposon RNA bound in MeR-PIWIL4:cleaved transposon RNA:TDRD9:MAEL:TDRKH


reactomeID: 5601897
pathwayName:
MeR-PIWIL4:2'-O-methyl-piRNA:TDRD9:MAEL:TDRKH dissociates and MeR-PIWIL4:2'-O-methylpiRNA, TDRD9, MAEL translocate from cytosol to nucleus in an unknown association and order of events


reactomeID: 158218
pathwayName:
prekallikrein + kininogen:C1q binding protein tetramer -&gt; prekallikrein:kininogen:C1q binding protein tetramer


reactomeID: 158251
pathwayName:
prekallikrein:kininogen:C1q binding protein tetramer -&gt; kallikrein:kininogen:C1q binding protein tetramer


reactomeID: 158311
pathwayName:
kallikrein:kininogen:C1q binding protein tetramer -&gt; kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin


reactomeID: 158145
pathwayName:
factor XI + platelet glycoprotein (GP) Ib:IX:V complex -&gt; factor XI:platelet glycoprotein (GP) Ib:IX:V complex


reactomeID: 158300
pathwayName:
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -&gt; factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)


reactomeID: 158419
pathwayName:
factor XI:platelet glycoprotein (GP) Ib:IX:V complex -&gt; factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)


reactomeID: 158137
pathwayName:
factor VIII:von Willibrand factor multimer -&gt; factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer


reactomeID: 140664
pathwayName:
prothrombin -&gt; activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)


reactomeID: 158781
pathwayName:
crosslinked fibrin multimer + tissue plasminogen activator (one-chain) -&gt; crosslinked fibrin multimer:tissue plasminogen activator (one-chain)


reactomeID: 158784
pathwayName:
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen


reactomeID: 158750
pathwayName:
crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin


reactomeID: 158747
pathwayName:
crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -&gt; crosslinked fibrin multimer:tissue plasminogen activator (two-chain)


reactomeID: 158756
pathwayName:
crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen


reactomeID: 158744
pathwayName:
crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -&gt; crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin


reactomeID: 158800
pathwayName:
fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -&gt; fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1


reactomeID: 158795
pathwayName:
fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -&gt; fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1


reactomeID: 158959
pathwayName:
urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -&gt; urokinase plasminogen activator:uPAR


reactomeID: 158982
pathwayName:
plasminogen:histidine-rich glycoprotein -&gt; plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)


reactomeID: 158942
pathwayName:
urokinase plasminogen activator (one-chain):uPAR -&gt; urokinase plasminogen activator (two-chain):uPAR


reactomeID: 158925
pathwayName:
plasminogen:histidine-rich glycoprotein -&gt; plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)


reactomeID: 159005
pathwayName:
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -&gt; PAI-1:urokinase plasminogen activator (two-chain):uPAR


reactomeID: 159001
pathwayName:
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -&gt; PAI-2:urokinase plasminogen activator (two-chain):uPAR


reactomeID: 9606151
pathwayName:
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1


reactomeID: 1112666
pathwayName:
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate


reactomeID: 975879
pathwayName:
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex


reactomeID: 9013986
pathwayName:
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR3 followed by their phosphorylation


reactomeID: 975100
pathwayName:
Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex


reactomeID: 975103
pathwayName:
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3  upon TLR7/8 or 9 activation


reactomeID: 936941
pathwayName:
Recruitment of TBK1/IKK epsilon to K63-pUb-TANK:K63-pUb-TRAF3:TRIF:activated TLR4 followed by their phosphorylation


reactomeID: 166721
pathwayName:
MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa


reactomeID: 5607725
pathwayName:
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP


reactomeID: 445752
pathwayName:
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform


reactomeID: 8985900
pathwayName:
p-Y701-STAT1, p-Y705-STAT3, p-Y649-STAT5 dissociates from IL9:p-Y116-IL9R:JAK1:IL2RG:p-904,939-JAK3:p-Y705-STAT3


reactomeID: 8986985
pathwayName:
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5


reactomeID: 8987033
pathwayName:
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5


reactomeID: 71515
pathwayName:
glycogen-glycogenin-1 + n orthophosphate =&gt; limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]


reactomeID: 71590
pathwayName:
glycogen-glycogenin-2 + n orthophosphate =&gt; limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]


reactomeID: 71593
pathwayName:
((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin =&gt; poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose


reactomeID: 453358
pathwayName:
poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate =&gt; glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]


reactomeID: 453339
pathwayName:
poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate =&gt; glycogenin-2 + n D-glucose 1-phosphate [PYGL]


reactomeID: 372843
pathwayName:
malate [mitochondrial matrix] + orthophosphate [cytosol] &lt;=&gt; malate [cytosol] + orthophosphate [mitochondrial matrix]


reactomeID: 198440
pathwayName:
malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] &lt;=&gt; malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]


reactomeID: 372449
pathwayName:
phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] =&gt; phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]


reactomeID: 70482
pathwayName:
1,3-bisphospho-D-glycerate + NADH + H+ &lt;=&gt; D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+


reactomeID: 198513
pathwayName:
Cytosolic glucose 6-phosphate is exchanged for orthophosphate from the endoplasmic reticulum lumen by SLC37A4


reactomeID: 70449
pathwayName:
D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ &lt;=&gt; 1,3-bisphospho-D-glycerate + NADH + H+


reactomeID: 71324
pathwayName:
ribose 5-phosphate + xylulose 5-phosphate &lt;=&gt; sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate


reactomeID: 163741
pathwayName:
D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate&lt;=&gt; xylulose 5-phosphate+ribose 5-phosphate 


reactomeID: 71334
pathwayName:
sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate &lt;=&gt; D-erythrose 4-phosphate + D-fructose 6-phosphate


reactomeID: 163764
pathwayName:
D-fructose 6-phosphate + D-erythrose 4-phosphate  &lt;=&gt;  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate


reactomeID: 71335
pathwayName:
xylulose 5-phosphate + D-erythrose 4-phosphate &lt;=&gt; D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate


reactomeID: 163751
pathwayName:
D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate   &lt;=&gt; xylulose 5-phosphate + D-erythrose 4-phosphate


reactomeID: 111215
pathwayName:
D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) =&gt; 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate


reactomeID: 73580
pathwayName:
D-ribose 5-phosphate + ATP =&gt; 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate


reactomeID: 1638032
pathwayName:
N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate


reactomeID: 109342
pathwayName:
Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation


reactomeID: 390276
pathwayName:
4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH =&gt; 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA


reactomeID: 390302
pathwayName:
tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH =&gt; octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA


reactomeID: 75886
pathwayName:
glycerol 3-phosphate + acyl-CoA =&gt; 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]


reactomeID: 8849969
pathwayName:
PI(4,5)P2, PI(3,4)P2 and PI(3,4,5)P3 are dephosphorylated to PI5P, PI3P and PI(3,4)P by INPP5F at the endosome membrane


reactomeID: 1606273
pathwayName:
Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)


reactomeID: 1861788
pathwayName:
Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)


reactomeID: 194674
pathwayName:
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR]


reactomeID: 194698
pathwayName:
4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2]


reactomeID: 194641
pathwayName:
4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol


reactomeID: 194642
pathwayName:
4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one


reactomeID: 194718
pathwayName:
4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)


reactomeID: 192036
pathwayName:
5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol


reactomeID: 192010
pathwayName:
5beta-cholestan-3alpha, 7alpha, 12alpha-triol is translocated from the cytosol to the mitochondrial matrix


reactomeID: 192042
pathwayName:
5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al


reactomeID: 193497
pathwayName:
5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al


reactomeID: 192054
pathwayName:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)


reactomeID: 193460
pathwayName:
3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)


reactomeID: 192335
pathwayName:
25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)


reactomeID: 192331
pathwayName:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA) is hydrated to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA


reactomeID: 193535
pathwayName:
25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA is hydrated to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA


reactomeID: 193455
pathwayName:
(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA


reactomeID: 193508
pathwayName:
(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA


reactomeID: 192341
pathwayName:
Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA


reactomeID: 193533
pathwayName:
Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA


reactomeID: 193491
pathwayName:
Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate


reactomeID: 193789
pathwayName:
Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one


reactomeID: 193755
pathwayName:
4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one


reactomeID: 193781
pathwayName:
5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol


reactomeID: 193774
pathwayName:
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix


reactomeID: 193715
pathwayName:
5beta-cholestan-3alpha,7alpha,24(S)-triol is translocated from the cytosol to the mitochondrial matrix


reactomeID: 193787
pathwayName:
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol


reactomeID: 193780
pathwayName:
5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al


reactomeID: 193719
pathwayName:
5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al


reactomeID: 193713
pathwayName:
3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)


reactomeID: 193737
pathwayName:
3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)


reactomeID: 193763
pathwayName:
Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA


reactomeID: 193821
pathwayName:
4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one


reactomeID: 193800
pathwayName:
5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol


reactomeID: 193832
pathwayName:
5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is translocated from the cytosol to the mitochondrial matrix


reactomeID: 163200
pathwayName:
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.


reactomeID: 73815
pathwayName:
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine &lt;=&gt; 5-phosphoribosylamine + L-glutamate +pyrophosphate


reactomeID: 73567
pathwayName:
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) &lt;=&gt; orotidine 5'-monophosphate (OMP) + pyrophosphate


reactomeID: 111746
pathwayName:
glutaredoxin (oxidized) + glutathione (reduced) =&gt; glutaredoxin (reduced) + glutathione (oxidized)


reactomeID: 112266
pathwayName:
thymine or uracil + 2-deoxy-D-ribose 1-phosphate &lt;=&gt; thymidine or deoxyuridine + orthophosphate [TYMP]


reactomeID: 109387
pathwayName:
(d)AMP, (d)GMP, or (d)IMP + H2O =&gt; (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)


reactomeID: 109514
pathwayName:
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O =&gt; thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]


reactomeID: 109449
pathwayName:
(d)CMP, TMP, or (d)UMP + H2O =&gt; (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)


reactomeID: 109380
pathwayName:
(d)CMP, TMP, or (d)UMP + H2O =&gt; (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)


reactomeID: 109480
pathwayName:
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O =&gt; thymidine or (deoxy)uridine + orthophosphate [NT5C]


reactomeID: 112265
pathwayName:
thymidine or deoxyuridine + orthophosphate &lt;=&gt; thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]


reactomeID: 200735
pathwayName:
Tetrahydrofolate polyglutamate (THF polyglutamate) + serine &lt;=&gt; 5,10-methyleneTHF polyglutamate + glycine


reactomeID: 200651
pathwayName:
5,10-methyleneTHF polyglutamate + glycine &lt;=&gt; tetrahydrofolate polyglutamate (THF polyglutamate) + serine


reactomeID: 508040
pathwayName:
glutamate + ATP + NADPH + H+ =&gt; L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]


reactomeID: 70723
pathwayName:
leu, ile, or val + alpha-ketoglutarate &lt;=&gt; a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]


reactomeID: 508189
pathwayName:
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate &lt;=&gt; leu, ile, or val + alpha-ketoglutarate [BCAT1]


reactomeID: 70724
pathwayName:
leu, ile, or val + alpha-ketoglutarate &lt;=&gt; a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]


reactomeID: 508179
pathwayName:
a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate &lt;=&gt; leu, ile, or val + alpha-ketoglutarate [BCAT2]


reactomeID: 70773
pathwayName:
beta-methylcrotonyl-CoA + ATP + CO2 &lt;=&gt; beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]


reactomeID: 508308
pathwayName:
beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O &lt;=&gt; beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]


reactomeID: 372480
pathwayName:
2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] &lt;=&gt; 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]


reactomeID: 70634
pathwayName:
ornithine (cytosolic) + citrulline (mitochondrial) =&gt; ornithine (mitochondrial) + citrulline (cytosolic)


reactomeID: 5333615
pathwayName:
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC


reactomeID: 76475
pathwayName:
Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and  hydrogen bromide


reactomeID: 72662
pathwayName:
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S


reactomeID: 156808
pathwayName:
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a  'closed-loop' conformation


reactomeID: 5419279
pathwayName:
Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)


reactomeID: 389976
pathwayName:
Beta-tubulin:GTP:Cofactor D+alpha-tubulin:GTP:Cofactor E-&gt; Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E


reactomeID: 389964
pathwayName:
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E+ Cofactor C-&gt; Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C


reactomeID: 389974
pathwayName:
Beta-tubulin:GTP:Cofactor D:alpha-tubulin:GTP:Cofactor E:Cofactor C-&gt; Beta-tubulin:GDP :alpha-tubulin:GTP heterodimer +Cofactor E+ Cofactor D+ Cofactor C+ Pi


reactomeID: 159763
pathwayName:
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus


reactomeID: 162830
pathwayName:
glucosaminyl-acyl-PI + dolichol phosphate D-mannose -&gt; mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate


reactomeID: 162798
pathwayName:
mannose(a1-4)glucosaminyl-acyl-PI + phosphatidylethanolamine -&gt; (ethanolamineP) mannose(al1-4)glucosaminyl-acyl-PI + diacylglycerol


reactomeID: 162873
pathwayName:
(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -&gt; mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate


reactomeID: 162821
pathwayName:
mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -&gt; mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate


reactomeID: 163069
pathwayName:
mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -&gt; (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol


reactomeID: 162797
pathwayName:
mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -&gt; mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI


reactomeID: 162742
pathwayName:
(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -&gt; (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI


reactomeID: 446193
pathwayName:
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein


reactomeID: 1022127
pathwayName:
OS9:SEL1:ERAD E3 ligase:DERL2 transports Ub-unfolded protein:(GlcNAc)2 (Man)9-5 from ERQC to cytosol


reactomeID: 964827
pathwayName:
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2


reactomeID: 981814
pathwayName:
GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position


reactomeID: 381426
pathwayName:
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)


reactomeID: 159046
pathwayName:
Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC


reactomeID: 158481
pathwayName:
Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC


reactomeID: 927789
pathwayName:
Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex


reactomeID: 6791227
pathwayName:
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6)  to yield 45S pre-rRNA


reactomeID: 6791228
pathwayName:
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA


reactomeID: 6791223
pathwayName:
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol


reactomeID: 6790906
pathwayName:
EMG1 of the SSU processome methylates pseudouridine-1248 of 18S rRNA yielding N(1)-methylpseudouridine-1248


reactomeID: 6790987
pathwayName:
NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842


reactomeID: 8868783
pathwayName:
TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248


reactomeID: 6785722
pathwayName:
Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript


reactomeID: 6793066
pathwayName:
TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937


reactomeID: 6786500
pathwayName:
ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34


reactomeID: 6786571
pathwayName:
CDKAL1:4Fe-4S methylthiolates N6-threonylcarbamoyladenosine-37 in tRNA yielding 2-methylthio-N6-threonylcarbamoyladenosine-37


reactomeID: 6782895
pathwayName:
TYW1:FMN:4Fe-4S  transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)


reactomeID: 6786854
pathwayName:
Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript


reactomeID: 6787591
pathwayName:
TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9


reactomeID: 629596
pathwayName:
Binding of acetylcholine to  highly calcium permeable postsynaptic nicotinic acetylcholine receptors


reactomeID: 8949609
pathwayName:
Formation of MIB complex containing the MICOS complex causes curvature of mitochondrial inner membrane


reactomeID: 211731
pathwayName:
Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region


reactomeID: 1299475
pathwayName:
TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix


reactomeID: 9033505
pathwayName:
PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12


reactomeID: 9033499
pathwayName:
PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol


reactomeID: 177939
pathwayName:
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)


reactomeID: 1250463
pathwayName:
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers


reactomeID: 1250498
pathwayName:
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.


reactomeID: 1306972
pathwayName:
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers


reactomeID: 1306957
pathwayName:
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR


reactomeID: 195280
pathwayName:
Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex


reactomeID: 4411365
pathwayName:
Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF


reactomeID: 5610767
pathwayName:
The intraflagellar transport B (IFT-B) complex is required for the transit of GLI:SUFU complexes to the ciliary tip


reactomeID: 5610766
pathwayName:
The intraflagellar transport A (IFT-A) complex is required for the transit of GLI:SUFU complexes to the ciliary base


reactomeID: 8944104
pathwayName:
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN


reactomeID: 9029158
pathwayName:
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS


reactomeID: 109530
pathwayName:
Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1


reactomeID: 109538
pathwayName:
Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3


reactomeID: 109539
pathwayName:
Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2


reactomeID: 109534
pathwayName:
Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1


reactomeID: 109529
pathwayName:
Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2


reactomeID: 109536
pathwayName:
Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1


reactomeID: 109527
pathwayName:
Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2


reactomeID: 727768
pathwayName:
Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4


reactomeID: 727740
pathwayName:
Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4


reactomeID: 8949688
pathwayName:
SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)


reactomeID: 216756
pathwayName:
Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle


reactomeID: 349657
pathwayName:
pre-beta HDL binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle


reactomeID: 174690
pathwayName:
TG-depleted chylomicron + spherical HDL =&gt; chylomicron remnant + spherical HDL:apoA-I:apoA-II:apoA-IV:apoC-II:apoC-III


reactomeID: 264695
pathwayName:
cholesterol + phosphatidylcholine (lecithin) =&gt; cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)


reactomeID: 174706
pathwayName:
chylomicron remnant:apoE:LDLR complex [plasma membrane] =&gt; chylomicron remnant:apoE:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)


reactomeID: 174808
pathwayName:
chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] =&gt; chylomicron remnant:apoE:LDLR complex [endosome membrane]


reactomeID: 171141
pathwayName:
LDL:LDLR complex [plasma membrane] =&gt; LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)


reactomeID: 432712
pathwayName:
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane


