# annotation

uniprotID: Q6UXU6
geneSymbol: TMEM92
name: Transmembrane protein 92
length: 159
go: ENSG00000167105;
opentargets: integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
snps: rs9894445 rs6504642 rs6504642
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MSQAWVPGLAPTLLFSLLAGPQKIAAKCGLILACPKGFKCCGDSCCQENELFPGPVRIFVIIFLVILSVFCICGLAKCFCRNCREPEPDSPVDCRGPLELPSIIPPERVRVSLSAPPPPYSEVILKPSLGPTPTEPPPPYSFRPEEYTGDQRGIDNPAF


uniprotID: Q96MW7
geneSymbol: TIGD1
name: Tigger transposable element-derived protein 1
length: 591
go: ENSG00000221944;
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: C9JQI7
geneSymbol: TMEM232
name: Transmembrane protein 232
length: 657
go: ENSG00000186952;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=C9JQI7-1; Sequence=Displayed; Name=1; IsoId=C9JQI7-2; Sequence=VSP_039352; Note=No experimental confirmation available.; 


uniprotID: Q96B96
geneSymbol: TMEM159
name: Promethin (Transmembrane protein 159)
length: 161
go: ENSG00000011638;
opentargets: integral component of membrane [GO:0016021]
snps: rs35345508 rs1046480 rs1063087
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVVAFMKSPVGQYLDSHPFLAFTLLVFIVMSAVPVGFFLLIVVLTTLAALLGVIILEGLVISVGGFSLLCILCGLGFVSLAMSGMMIASYVVVSSLISCWFSPRPLTQQNTSCDFLPAMKSAEFEGLYQE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96B96-1; Sequence=Displayed; Name=2; IsoId=Q96B96-2; Sequence=VSP_056078; Note=No experimental confirmation available.; 


uniprotID: Q495A1
geneSymbol: TIGIT
pdb: 3Q0H;3RQ3;3UCR;3UDW;5V52;
length: 244
go: ENSG00000181847;
snps: rs13098836
name:
T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; signaling receptor binding [GO:0005102]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of T cell activation [GO:0050868]; positive regulation of interleukin-10 production [GO:0032733]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q495A1-1; Sequence=Displayed; Name=2; IsoId=Q495A1-2; Sequence=VSP_027634, VSP_027635; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19011627}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}.


uniprotID: Q5W0B7
geneSymbol: TMEM236
name: Transmembrane protein 236
length: 351
go: ENSG00000148483;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9BX74
geneSymbol: TM2D1
name: TM2 domain-containing protein 1 (Amyloid-beta-binding protein) (hBBP)
length: 207
go: ENSG00000162604;
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; nucleoplasm [GO:0005654]; amyloid-beta binding [GO:0001540]; G protein-coupled receptor activity [GO:0004930]; apoptotic signaling pathway [GO:0097190]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11278849}; Multi-pass membrane protein {ECO:0000269|PubMed:11278849}.


uniprotID: O75674
geneSymbol: TOM1L1
pdb: 3RRU;
name: TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1)
length: 476
go: ENSG00000141198;
snps: rs16955377
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Golgi stack [GO:0005795]; lysosome [GO:0005764]; clathrin binding [GO:0030276]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; SH3 domain binding [GO:0017124]; ubiquitin binding [GO:0043130]; activation of protein kinase activity [GO:0032147]; intracellular protein transport [GO:0006886]; negative regulation of mitotic nuclear division [GO:0045839]; positive regulation of protein autophosphorylation [GO:0031954]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O75674-1; Sequence=Displayed; Name=2; IsoId=O75674-2; Sequence=VSP_056852, VSP_056853; Note=No experimental confirmation available.; Name=3; IsoId=O75674-3; Sequence=VSP_057424; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack. Endosome membrane {ECO:0000305}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=A small proportion is membrane-associated. {ECO:0000250}.


uniprotID: A0A1B0GVZ9
geneSymbol: TMEM269
name: Transmembrane protein 269
length: 245
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: Q02763
geneSymbol: TEK
reactome: R-HSA-210993;R-HSA-5673001;
pdb: 1FVR;2GY5;2GY7;2OO8;2OSC;2P4I;2WQB;3BEA;3L8P;4K0V;4X3J;5MYA;5MYB;5UTK;
length: 1124
go: ENSG00000120156;
drug: DB00415;DB08221;DB08901;DB08896;DB05294;DB05153;
name:
Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; basal plasma membrane [GO:0009925]; basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; extracellular region [GO:0005576]; focal adhesion [GO:0005925]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; microtubule organizing center [GO:0005815]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; signaling receptor activity [GO:0038023]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; cell-cell signaling [GO:0007267]; definitive hemopoiesis [GO:0060216]; endochondral ossification [GO:0001958]; endothelial cell proliferation [GO:0001935]; glomerulus vasculature development [GO:0072012]; heart development [GO:0007507]; heart trabecula formation [GO:0060347]; leukocyte migration [GO:0050900]; MAPK cascade [GO:0000165]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of inflammatory response [GO:0050728]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of actin cytoskeleton reorganization [GO:2000251]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of intracellular signal transduction [GO:1902533]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; protein autophosphorylation [GO:0046777]; protein complex oligomerization [GO:0051259]; regulation of endothelial cell apoptotic process [GO:2000351]; regulation of establishment or maintenance of cell polarity [GO:0032878]; regulation of vascular permeability [GO:0043114]; response to cAMP [GO:0051591]; response to estrogen [GO:0043627]; response to hypoxia [GO:0001666]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate adhesion-dependent cell spreading [GO:0034446]; Tie signaling pathway [GO:0048014]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

snps:
rs35969327 rs35814893 rs146169480 rs682632 rs34032300 rs1334811 rs35030851 rs35378598 rs56367117 rs4631561 rs80338908 rs80338909 rs80338909 rs387906745 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q02763-1; Sequence=Displayed; Name=2; IsoId=Q02763-2; Sequence=VSP_042138; Name=3; IsoId=Q02763-3; Sequence=VSP_042137, VSP_042138, VSP_042139; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:19079259, ECO:0000269|PubMed:27270174}; Single-pass type I membrane protein. Cell junction {ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120, ECO:0000269|PubMed:27270174}. Cell junction, focal adhesion {ECO:0000305|PubMed:19293632}. Cytoplasm, cytoskeleton. Secreted {ECO:0000269|PubMed:11806244}. Note=Recruited to cell-cell contacts in quiescent endothelial cells (PubMed:18425120, PubMed:18425119). Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted (PubMed:11806244). {ECO:0000269|PubMed:11806244, ECO:0000269|PubMed:18425119, ECO:0000269|PubMed:18425120}.


uniprotID: Q96B49
geneSymbol: TOMM6
reactome: R-HSA-1268020;R-HSA-5205685;
sequence: MASSTVPVSAAGSANETPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV
length: 74
location: SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18331822}.
name:
Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog)

opentargets:
mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein transport [GO:0015031]


uniprotID: Q86T26
geneSymbol: TMPRSS11B
name: Transmembrane protease serine 11B (EC 3.4.21.-) (Airway trypsin-like protease 5)
length: 416
go: ENSG00000185873;
snps: rs12331141 rs2319796 rs2319797
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24498351}; Single-pass type II membrane protein {ECO:0000305}.


uniprotID: O94826
geneSymbol: TOMM70
reactome: R-HSA-1268020;R-HSA-5205685;R-HSA-5689880;
length: 608
go: ENSG00000154174;
name:
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein transmembrane transporter activity [GO:0008320]; protein targeting to mitochondrion [GO:0006626]

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.


uniprotID: Q9NV12
geneSymbol: TMEM140
name: Transmembrane protein 140
length: 185
go: ENSG00000146859;
opentargets: integral component of membrane [GO:0016021]
snps: rs292500 rs3800592 rs11558290 rs292501
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MAGPRPRWRDQLLFMSIIVLVIVVICLMFYALLWEAGNLTDLPNLRIGFYNFCLWNEDTSTLQCHQFPELEALGVPRVGLGLARLGVYGSLVLTLFAPQPLLLAQCNSDERAWRLAVGFLAVSSVLLAGGLGLFLSYVWKWVRLSLPGPGFLALGSAQALLILLLIAMAVFPLRAERAESKLESC


uniprotID: Q4KMG9
geneSymbol: TMEM52B
name: Transmembrane protein 52B
length: 183
go: ENSG00000165685;
opentargets: extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MGVRVHVVAASALLYFILLSGTRCEENCGNPEHCLTTDWVHLWYIWLLVVIGALLLLCGLTSLCFRCCCLSRQQNGEDGGPPPCEVTVIAFDHDSTLQSTITSLQSVFGPAARRILAVAHSHSSLGQLPSSLDTLPGYEEALHMSRFTVAMCGQKAPDLPPVPEEKQLPPTEKESTRIVDSWN

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q4KMG9-1; Sequence=Displayed; Name=2; IsoId=Q4KMG9-2; Sequence=VSP_026640; 


uniprotID: Q6UXZ0
geneSymbol: TMIGD1
name: Transmembrane and immunoglobulin domain-containing protein 1
length: 262
go: ENSG00000182271;
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; negative regulation of apoptotic process [GO:0043066]; regulation of cell migration [GO:0030334]; regulation of cell proliferation [GO:0042127]; regulation of membrane permeability [GO:0090559]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6UXZ0-1; Sequence=Displayed; Name=2; IsoId=Q6UXZ0-2; Sequence=VSP_017075, VSP_017076; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26342724}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:26342724}.


uniprotID: Q8N614
geneSymbol: TMEM156
name: Transmembrane protein 156
length: 296
go: ENSG00000121895;
opentargets: integral component of membrane [GO:0016021]
snps: rs35576563 rs11542133 rs2276887
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8IU80
geneSymbol: TMPRSS6
reactome: R-HSA-1442490;R-HSA-1474228;
name: Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2)
length: 811
go: ENSG00000187045;
sequence:

opentargets:
extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; intracellular [GO:0005622]; plasma membrane [GO:0005886]; metalloendopeptidase activity [GO:0004222]; serine-type endopeptidase activity [GO:0004252]; angiogenesis [GO:0001525]; cellular iron ion homeostasis [GO:0006879]; collagen catabolic process [GO:0030574]; extracellular matrix disassembly [GO:0022617]; extracellular matrix organization [GO:0030198]; fibrinolysis [GO:0042730]; intracellular signal transduction [GO:0035556]; iron ion homeostasis [GO:0055072]; membrane protein proteolysis [GO:0033619]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; proteolysis [GO:0006508]; self proteolysis [GO:0097264]

snps:
rs199474803 rs267607121 rs776877803 rs749106338 rs754848810 rs199474802 rs2235324 rs2235324 rs776180387 rs5995378 rs199474804 rs137853119 rs117576908 rs137853120 rs387907018 rs770897887 rs773272073 rs769083817 rs855791 rs11703011 rs199474805 rs776069764 rs139105452 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8IU80-4; Sequence=Displayed; Name=2; IsoId=Q8IU80-1; Sequence=VSP_035562; Name=3; IsoId=Q8IU80-2; Sequence=VSP_008379, VSP_008380; Note=No experimental confirmation available. {ECO:0000305}; Name=4; IsoId=Q8IU80-5; Sequence=VSP_035562, VSP_035563; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:20518742, ECO:0000269|PubMed:25588876}; Single-pass type II membrane protein {ECO:0000269|PubMed:12149247, ECO:0000269|PubMed:20518742}. Note=The processed, activated two-chains form is released in the extracellular space. {ECO:0000269|PubMed:25156943}.


uniprotID: Q8N3G9
geneSymbol: TMEM130
name: Transmembrane protein 130
length: 435
go: ENSG00000166448;
snps: rs17161477
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of plasma membrane [GO:0005887]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N3G9-1; Sequence=Displayed; Name=2; IsoId=Q8N3G9-2; Sequence=VSP_023258; Name=3; IsoId=Q8N3G9-3; Sequence=VSP_023257, VSP_023258; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11256614}; Single-pass type I membrane protein {ECO:0000269|PubMed:11256614}.


uniprotID: Q9Y5L0
geneSymbol: TNPO3
pdb: 4C0O;4C0P;4C0Q;4OL0;
name: Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)
length: 923
go: ENSG00000064419;
snps: rs587777431
sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; nuclear localization sequence binding [GO:0008139]; protein transporter activity [GO:0008565]; signaling receptor activity [GO:0038023]; protein import into nucleus [GO:0006606]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=2; Synonyms=TRN-SR2; IsoId=Q9Y5L0-2; Sequence=Displayed; Name=1; IsoId=Q9Y5L0-1; Sequence=VSP_030174; Name=3; IsoId=Q9Y5L0-3; Sequence=VSP_011178; Note=No experimental confirmation available.; Name=4; IsoId=Q9Y5L0-5; Sequence=VSP_045494; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10713112}. Nucleus {ECO:0000269|PubMed:10713112}.


uniprotID: P11387
geneSymbol: TOP1
reactome: R-HSA-4615885;
pdb: 1A31;1A35;1A36;1EJ9;1K4S;1K4T;1LPQ;1NH3;1R49;1RR8;1RRJ;1SC7;1SEU;1T8I;1TL8;
name: DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)
length: 765
go: ENSG00000198900;
drug: DB05806;DB04690;DB04882;DB05129;DB00762;DB05482;DB04967;DB05630;DB01030;DB06069;
snps: rs6029542 rs267607131
sequence:

opentargets:
DNA topoisomerase complex (ATP-hydrolyzing) [GO:0009330]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; perikaryon [GO:0043204]; protein-DNA complex [GO:0032993]; replication fork protection complex [GO:0031298]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA topoisomerase type I activity [GO:0003917]; double-stranded DNA binding [GO:0003690]; protein domain specific binding [GO:0019904]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; supercoiled DNA binding [GO:0097100]; chromatin remodeling [GO:0006338]; chromosome segregation [GO:0007059]; circadian regulation of gene expression [GO:0032922]; circadian rhythm [GO:0007623]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; embryonic cleavage [GO:0040016]; peptidyl-serine phosphorylation [GO:0018105]; phosphorylation [GO:0016310]; programmed cell death [GO:0012501]; response to drug [GO:0042493]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12149243}. Nucleus, nucleoplasm {ECO:0000269|PubMed:12149243}. Note=Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumoylated forms found in both nucleoplasm and nucleoli.


uniprotID: Q9Y277
geneSymbol: VDAC3
reactome: R-HSA-5689880;R-HSA-8949215;
length: 283
go: ENSG00000078668;
drug: DB01375;DB06098;
location: SUBCELLULAR LOCATION: Mitochondrion outer membrane.
name:
Voltage-dependent anion-selective channel protein 3 (VDAC-3) (hVDAC3) (Outer mitochondrial membrane protein porin 3)

sequence:

opentargets:
extracellular exosome [GO:0070062]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; pore complex [GO:0046930]; nucleotide binding [GO:0000166]; porin activity [GO:0015288]; voltage-gated anion channel activity [GO:0008308]; adenine transport [GO:0015853]; behavioral fear response [GO:0001662]; learning [GO:0007612]; neuron-neuron synaptic transmission [GO:0007270]; regulation of cilium assembly [GO:1902017]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y277-1; Sequence=Displayed; Name=2; IsoId=Q9Y277-2; Sequence=VSP_005079; 


uniprotID: Q9H320
geneSymbol: VCX
length: 206
go: ENSG00000182583;
snps: rs6639946 rs78342118
name:
Variable charge X-linked protein 1 (Variable charge protein on X with ten repeats) (VCX-10r) (Variably charged protein X-B1) (VCX-B1)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; brain development [GO:0007420]; chromatin organization [GO:0006325]; ribosome assembly [GO:0042255]; spermatogenesis [GO:0007283]


uniprotID: P49767
geneSymbol: VEGFC
reactome: R-HSA-114608;R-HSA-194313;R-HSA-195399;
pdb: 2X1W;2X1X;4BSK;
length: 419
go: ENSG00000150630;
location: SUBCELLULAR LOCATION: Secreted.
name:
Vascular endothelial growth factor C (VEGF-C) (Flt4 ligand) (Flt4-L) (Vascular endothelial growth factor-related protein) (VRP)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; angiogenesis [GO:0001525]; animal organ morphogenesis [GO:0009887]; cellular response to leukemia inhibitory factor [GO:1990830]; induction of positive chemotaxis [GO:0050930]; morphogenesis of embryonic epithelium [GO:0016331]; negative regulation of blood pressure [GO:0045776]; platelet degranulation [GO:0002576]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of lymphangiogenesis [GO:1901492]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein secretion [GO:0050714]; regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030947]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; signal transduction [GO:0007165]; sprouting angiogenesis [GO:0002040]; substrate-dependent cell migration [GO:0006929]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]


uniprotID: P62760
geneSymbol: VSNL1
name: Visinin-like protein 1 (VILIP) (VLP-1) (Hippocalcin-like protein 3) (HLP3)
length: 191
go: ENSG00000163032;
snps: rs1042674 rs1042685
sequence:
MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDPSIVLLLQCDIQK

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; calcium ion binding [GO:0005509]; negative regulation of insulin secretion [GO:0046676]; positive regulation of exocytosis [GO:0045921]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]


uniprotID: P38435
geneSymbol: GGCX
reactome: R-HSA-159740;
length: 758
go: ENSG00000115486;
drug: DB01125;DB00100;DB00036;DB00055;DB00142;DB00170;DB01022;
name:
Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; gamma-glutamyl carboxylase activity [GO:0008488]; blood coagulation [GO:0007596]; cellular protein modification process [GO:0006464]; peptidyl-glutamic acid carboxylation [GO:0017187]

snps:
rs121909677 rs699664 rs121909675 rs121909681 rs121909682 rs121909676 rs121909679 rs28928872 rs121909678 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P38435-1; Sequence=Displayed; Name=2; IsoId=P38435-2; Sequence=VSP_046179; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10910912}; Multi-pass membrane protein {ECO:0000269|PubMed:10910912}.


uniprotID: P18206
geneSymbol: VCL
name: Vinculin (Metavinculin) (MV)
length: 1134
go: ENSG00000035403;
snps: rs17853882 rs71579353 rs16931179 rs71579375 rs121917776
reactome:
R-HSA-114608;R-HSA-445355;R-HSA-5674135;R-HSA-6798695;R-HSA-6802946;R-HSA-6802948;R-HSA-6802949;R-HSA-6802952;R-HSA-6802955;

pdb:
1RKC;1RKE;1SYQ;1TR2;1YDI;2GWW;2HSQ;2IBF;3H2U;3H2V;3JBK;3MYI;3RF3;3S90;3TJ5;3TJ6;3VF0;4DJ9;4EHP;4LN2;4LNP;4PR9;5L0C;5L0D;5L0F;5L0G;5L0H;5L0I;5L0J;5O2Q;6FUY;

sequence:

opentargets:
adherens junction [GO:0005912]; brush border [GO:0005903]; cell [GO:0005623]; cell-cell adherens junction [GO:0005913]; cell-cell junction [GO:0005911]; cell-substrate junction [GO:0030055]; costamere [GO:0043034]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular vesicle [GO:1903561]; fascia adherens [GO:0005916]; ficolin-1-rich granule lumen [GO:1904813]; focal adhesion [GO:0005925]; inner dense plaque of desmosome [GO:0090637]; membrane raft [GO:0045121]; outer dense plaque of desmosome [GO:0090636]; plasma membrane [GO:0005886]; podosome [GO:0002102]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; secretory granule lumen [GO:0034774]; specific granule lumen [GO:0035580]; terminal web [GO:1990357]; zonula adherens [GO:0005915]; actin binding [GO:0003779]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; structural molecule activity [GO:0005198]; ubiquitin protein ligase binding [GO:0031625]; adherens junction assembly [GO:0034333]; apical junction assembly [GO:0043297]; axon extension [GO:0048675]; cell adhesion [GO:0007155]; cell-matrix adhesion [GO:0007160]; epithelial cell-cell adhesion [GO:0090136]; lamellipodium assembly [GO:0030032]; morphogenesis of an epithelium [GO:0002009]; muscle contraction [GO:0006936]; negative regulation of cell migration [GO:0030336]; neutrophil degranulation [GO:0043312]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; protein localization to cell surface [GO:0034394]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=2; Synonyms=Metavinculin; IsoId=P18206-1; Sequence=Displayed; Name=1; Synonyms=Vinculin; IsoId=P18206-2; Sequence=VSP_006731; Name=3; IsoId=P18206-3; Sequence=VSP_011857, VSP_011858, VSP_011859; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P12003}; Peripheral membrane protein {ECO:0000250|UniProtKB:P12003}; Cytoplasmic side {ECO:0000250|UniProtKB:P12003}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P12003}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P12003}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P85972}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q64727}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64727}; Cytoplasmic side {ECO:0000250|UniProtKB:Q64727}. Note=Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions. {ECO:0000250|UniProtKB:P12003}.


uniprotID: P54219
geneSymbol: SLC18A1
reactome: R-HSA-442660;
length: 525
go: ENSG00000036565;
drug: DB01363;DB01577;DB01442;DB00368;DB00206;
name:
Chromaffin granule amine transporter (Solute carrier family 18 member 1) (Vesicular amine transporter 1) (VAT1)

sequence:

opentargets:
cell junction [GO:0030054]; clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; drug transmembrane transporter activity [GO:0015238]; monoamine transmembrane transporter activity [GO:0008504]; serotonin:sodium symporter activity [GO:0005335]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; monoamine transport [GO:0015844]; neurotransmitter transport [GO:0006836]

snps:
rs2270641 rs17092144 rs17215815 rs17215822 rs17215801 rs2270637 rs17222218 rs1390938 rs17215808 rs17222092 rs17222120 rs17215759 rs17092104 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P54219-1; Sequence=Displayed; Name=2; Synonyms=VMAT1delta15; IsoId=P54219-2; Sequence=VSP_046305; Note=Unable to uptake serotonin.; Name=3; IsoId=P54219-3; Sequence=VSP_046304; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16326835, ECO:0000269|PubMed:8643547}; Multi-pass membrane protein {ECO:0000269|PubMed:16326835}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R090}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16326835}; Multi-pass membrane protein {ECO:0000269|PubMed:16326835}.


uniprotID: P63121
geneSymbol: HERVK_113
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 113 Pro protein (HERV-K113 envelope protein) (HERV-K_19p13.11 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGISTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGVEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQEREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63121-1; Sequence=Displayed; 


uniprotID: Q96AX1
geneSymbol: VPS33A
pdb: 4BX8;4BX9;
name: Vacuolar protein sorting-associated protein 33A (hVPS33A)
length: 596
go: ENSG00000139719;
snps: rs34996966 rs767748011
sequence:

opentargets:
autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; perinuclear region of cytoplasm [GO:0048471]; autophagosome maturation [GO:0097352]; endosome to lysosome transport [GO:0008333]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; platelet formation [GO:0030220]; protein transport [GO:0015031]; regulation of developmental pigmentation [GO:0048070]; regulation of lysosomal lumen pH [GO:0035751]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q63615}. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000305}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24554770}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}.


uniprotID: Q9Y279
geneSymbol: VSIG4
pdb: 2ICC;2ICE;2ICF;5IMK;5IML;
name: V-set and immunoglobulin domain-containing protein 4 (Protein Z39Ig)
length: 399
go: ENSG00000155659;
snps: rs34581041 rs34222730 rs17315645 rs35553694
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; complement activation, alternative pathway [GO:0006957]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y279-1; Sequence=Displayed; Name=2; IsoId=Q9Y279-2; Sequence=VSP_012813; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y279-3; Sequence=VSP_041213; 


uniprotID: O95670
geneSymbol: ATP6V1G2
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 118
go: ENSG00000213760;
name:
V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2)

sequence:
MASQSQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEVEQYRREREHEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRPQVHPNYRISA

opentargets:
cytosol [GO:0005829]; melanosome [GO:0042470]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; ATPase activity, coupled to transmembrane movement of substances [GO:0042626]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O95670-1; Sequence=Displayed; Name=2; IsoId=O95670-2; Sequence=VSP_045909; Note=No experimental confirmation available.; Name=3; IsoId=O95670-3; Sequence=VSP_047411; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Melanosome {ECO:0000269|PubMed:17081065}. Note=Highly enriched in late-stage melanosomes.


uniprotID: Q6Q795
name: Putative viral protein-binding protein C1
length: 121
opentargets: protein-containing complex [GO:0032991]
sequence:
MEEVIQAGLAQWSRQKGLALPWDRTRGHPDVPWRNLTSSPTRPLAQPAGSCMPAEPSPAAHYHQLHVHLQLLPSDLSERPGLRLAPLALVEVGMTLPVPQTPLPHVTQQQKLAPGRQLCPW


uniprotID: O95231
geneSymbol: VENTX
name: Homeobox protein VENTX (VENT homeobox homolog) (VENT-like homeobox protein 2)
length: 258
go: ENSG00000151650;
snps: rs2240892 rs2240891 rs2270192 rs9418952 rs9418953
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; multicellular organism development [GO:0007275]; positive regulation of transcription by RNA polymerase II [GO:0045944]


uniprotID: Q8TAG6
geneSymbol: VXN
name: Vexin
length: 207
go: ENSG00000169085;
sequence:

opentargets:
nucleus [GO:0005634]; plasma membrane [GO:0005886]; neurogenesis [GO:0022008]; neuron differentiation [GO:0030182]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TAG6-1; Sequence=Displayed; Name=2; IsoId=Q8TAG6-2; Sequence=VSP_038986; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BG31}. Nucleus {ECO:0000250|UniProtKB:Q8BG31}. Note=Nuclear localization is essential for its function in neurogenesis. {ECO:0000250|UniProtKB:Q8BG31}.


uniprotID: P63123
geneSymbol: ERVK-18
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 18 Pro protein (HERV-K(C1a) Pro protein) (HERV-K110 Pro protein) (HERV-K18 Pro protein) (HERV-K_1q23.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAVIQGKQLEGLVDTGADVSIIALNQWPKNWPKQKTVTGLVGIVTASEVYQSTEILHCLGPHNQESTVQPMITSIPLNLWGRDLLQQWGAEITMTATLYSPMSQKIMTKMGYIPGKGLGKNEDGIKVPIEAKINHGREGTGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63123-1; Sequence=Displayed; 


uniprotID: Q8N5D0
geneSymbol: WDTC1
reactome: R-HSA-8951664;
pdb: 3I7N;
name: WD and tetratricopeptide repeats protein 1
length: 677
go: ENSG00000142784;
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; enzyme inhibitor activity [GO:0004857]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; cellular chemical homeostasis [GO:0055082]; cellular response to insulin stimulus [GO:0032869]; glucose metabolic process [GO:0006006]; in utero embryonic development [GO:0001701]; multicellular organism growth [GO:0035264]; negative regulation of fatty acid biosynthetic process [GO:0045717]; negative regulation of transcription by RNA polymerase II [GO:0000122]; post-translational protein modification [GO:0043687]; protein ubiquitination [GO:0016567]; regulation of cell size [GO:0008361]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q8N5D0-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8N5D0-2; Sequence=VSP_009292; Note=No experimental confirmation available.; Name=3; IsoId=Q8N5D0-3; Sequence=VSP_009291; Note=No experimental confirmation available.; Name=4; IsoId=Q8N5D0-4; Sequence=VSP_009290; Note=No experimental confirmation available.; Name=5; IsoId=Q8N5D0-5; Sequence=VSP_009290, VSP_009291; Note=No experimental confirmation available.; Name=6; IsoId=Q8N5D0-6; Sequence=VSP_009290, VSP_009292; Note=No experimental confirmation available.; 


uniprotID: O15195
geneSymbol: VILL
name: Villin-like protein
length: 856
go: ENSG00000136059;
snps: rs1892814 rs9816693
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200]; actin filament capping [GO:0051693]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15195-1; Sequence=Displayed; Name=2; IsoId=O15195-2; Sequence=VSP_006729; Note=No experimental confirmation available.; 


uniprotID: Q8N0U8
geneSymbol: VKORC1L1
reactome: R-HSA-6806664;
name: Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1-like protein 1) (EC 1.17.4.4)
length: 176
go: ENSG00000196715;
drug: DB00170;
sequence:
MAAPVLLRVSVPRWERVARYAVCAAGILLSIYAYHVEREKERDPEHRALCDLGPWVKCSAALASRWGRGFGLLGSIFGKDGVLNQPNSVFGLIFYILQLLLGMTASAVAALILMTSSIMSVVGSLYLAYILYFVLKEFCIICIVTYVLNFLLLIINYKRLVYLNEAWKRQLQPKQD

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057]; cellular response to oxidative stress [GO:0034599]; peptidyl-glutamic acid carboxylation [GO:0017187]; vitamin K metabolic process [GO:0042373]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N0U8-1; Sequence=Displayed; Name=2; IsoId=Q8N0U8-2; Sequence=VSP_055709; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}; Multi-pass membrane protein {ECO:0000269|PubMed:21367861, ECO:0000269|PubMed:24532791}.


uniprotID: P98155
geneSymbol: VLDLR
reactome: R-HSA-8866376;R-HSA-8866427;R-HSA-8964046;
pdb: 1V9U;3DPR;6BYV;
name: Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R)
length: 873
go: ENSG00000147852;
drug: DB03017;
snps: rs6149 rs34761707 rs6146 rs34753566 rs35724190 rs35948251 rs35334949
sequence:

opentargets:
clathrin-coated pit [GO:0005905]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; very-low-density lipoprotein particle [GO:0034361]; apolipoprotein binding [GO:0034185]; calcium ion binding [GO:0005509]; calcium-dependent protein binding [GO:0048306]; glycoprotein transporter activity [GO:0034437]; low-density lipoprotein particle receptor activity [GO:0005041]; reelin receptor activity [GO:0038025]; very-low-density lipoprotein particle binding [GO:0034189]; very-low-density lipoprotein particle receptor activity [GO:0030229]; axon guidance [GO:0007411]; cholesterol metabolic process [GO:0008203]; dendrite morphogenesis [GO:0048813]; glycoprotein transport [GO:0034436]; lipid transport [GO:0006869]; low-density lipoprotein particle receptor catabolic process [GO:0032802]; memory [GO:0007613]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; positive regulation of dendrite development [GO:1900006]; positive regulation of protein kinase activity [GO:0045860]; receptor-mediated endocytosis [GO:0006898]; reelin-mediated signaling pathway [GO:0038026]; signal transduction [GO:0007165]; ventral spinal cord development [GO:0021517]; very-low-density lipoprotein particle clearance [GO:0034447]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=P98155-1; Sequence=Displayed; Name=Short; IsoId=P98155-2; Sequence=VSP_004304; 

location:
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.


uniprotID: O00534
geneSymbol: VWA5A
length: 786
go: ENSG00000110002;
opentargets: nucleoplasm [GO:0005654]; nucleus [GO:0005634]
snps: rs35496433 rs35215239 rs2276054 rs2276053 rs117689747 rs200614108
name:
von Willebrand factor A domain-containing protein 5A (Breast cancer suppressor candidate 1) (BCSC-1) (Loss of heterozygosity 11 chromosomal region 2 gene A protein)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=c/f; IsoId=O00534-1; Sequence=Displayed; Name=2; Synonyms=g; IsoId=O00534-2; Sequence=VSP_013367, VSP_013368; Name=3; Synonyms=a/d; IsoId=O00534-3; Sequence=VSP_013366; Name=4; Synonyms=b/e; IsoId=O00534-4; Sequence=VSP_013364, VSP_013365; 


uniprotID: Q7Z5L0
geneSymbol: VMO1
name: Vitelline membrane outer layer protein 1 homolog
length: 202
go: ENSG00000182853;
opentargets: extracellular exosome [GO:0070062]
snps: rs4790706 rs2279961
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q7Z5L0-1; Sequence=Displayed; Name=2; IsoId=Q7Z5L0-2; Sequence=VSP_045706, VSP_045707; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z5L0-3; Sequence=VSP_045708; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z5L0-4; Sequence=VSP_047219; Note=No experimental confirmation available.; 


uniprotID: Q8TDU5
geneSymbol: VN1R17P
name: Putative vomeronasal receptor-like protein 4 (G-protein coupled receptor GPCR23) (hGPCR23)
length: 208
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]


uniprotID: O95497
geneSymbol: VNN1
reactome: R-HSA-163125;R-HSA-199220;R-HSA-6798695;
pdb: 4CYF;4CYG;4CYY;
length: 513
go: ENSG00000112299;
snps: rs2294757 rs2272996 rs45610032 rs45624336 rs45523444 rs34535050 rs45562238 rs35938565
name:
Pantetheinase (EC 3.5.1.92) (Pantetheine hydrolase) (Tiff66) (Vascular non-inflammatory molecule 1) (Vanin-1)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; azurophil granule membrane [GO:0035577]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; pantetheine hydrolase activity [GO:0017159]; acute inflammatory response [GO:0002526]; cell-cell adhesion [GO:0098609]; chronic inflammatory response [GO:0002544]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902176]; neutrophil degranulation [GO:0043312]; pantothenate metabolic process [GO:0015939]; positive regulation of T cell differentiation in thymus [GO:0033089]; response to oxidative stress [GO:0006979]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11491533}; Lipid-anchor, GPI-anchor {ECO:0000305}.


uniprotID: O95498
geneSymbol: VNN2
reactome: R-HSA-163125;R-HSA-199220;
length: 520
go: ENSG00000112303;
snps: rs33950336 rs2294760 rs35993077 rs33920182 rs36092168 rs4895944
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
name:
Vascular non-inflammatory molecule 2 (Vanin-2) (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; pantetheine hydrolase activity [GO:0017159]; pantothenate metabolic process [GO:0015939]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=O95498-1; Sequence=Displayed; Name=2; Synonyms=GPI-80 variant protein 3; IsoId=O95498-2; Sequence=VSP_038557; Name=3; Synonyms=GPI-80 variant protein 2; IsoId=O95498-3; Sequence=VSP_038558, VSP_038559; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=GPI-80 variant protein 1; IsoId=O95498-4; Sequence=VSP_038556, VSP_038560; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=GPI-80 variant protein 4; IsoId=O95498-5; Sequence=VSP_038554, VSP_038555; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; IsoId=O95498-6; Sequence=VSP_044912; Note=No experimental confirmation available.; 


uniprotID: Q96AW1
geneSymbol: VOPP1
length: 172
go: ENSG00000154978;
name:
Vesicular, overexpressed in cancer, prosurvival protein 1 (EGFR-coamplified and overexpressed protein) (ECop) (Glioblastoma-amplified secreted protein) (Putative NF-kappa-B-activating protein 055N)

sequence:
MRRQPAKVAALLLGLLLECTEAKKHCWYFEGLYPTYYICRSYEDCCGSRCCVRALSIQRLWYFWFLLMMGVLFCCGAGFFIRRRMYPPPLIEEPAFNVSYTRQPPNPGPGAQQPGPPYYTDPGGPGMNPVGNSMAMAFQVPPNSPQGSVACPPPPAYCNTPPPPYEQVVKAK

opentargets:
cytoplasmic vesicle membrane [GO:0030659]; endosome [GO:0005768]; integral component of organelle membrane [GO:0031301]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96AW1-1; Sequence=Displayed; Name=2; IsoId=Q96AW1-2; Sequence=VSP_043868; Note=No experimental confirmation available.; Name=3; IsoId=Q96AW1-3; Sequence=VSP_043867; Note=No experimental confirmation available.; Name=4; IsoId=Q96AW1-4; Sequence=VSP_055723; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:20571887}; Single-pass type I membrane protein {ECO:0000269|PubMed:20571887}. Note=When overexpressed, localizes in the nucleus and perinuclear regions.


uniprotID: Q9HBG4
geneSymbol: ATP6V0A4
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 840
go: ENSG00000105929;
snps: rs10258719 rs1443883930 rs121908368 rs1026435 rs3807153 rs3807154 rs28939081 rs267606671
name:
V-type proton ATPase 116 kDa subunit a isoform 4 (V-ATPase 116 kDa isoform a4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)

sequence:

opentargets:
apical part of cell [GO:0045177]; apical plasma membrane [GO:0016324]; brush border membrane [GO:0031526]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; excretion [GO:0007588]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; ossification [GO:0001503]; proton transmembrane transport [GO:1902600]; regulation of pH [GO:0006885]; sensory perception of sound [GO:0007605]; transferrin transport [GO:0033572]; vacuolar acidification [GO:0007035]

location:
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Present at high density almost exclusively on the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron.


uniprotID: Q9H7D7
geneSymbol: WDR26
length: 661
go: ENSG00000162923;
name:
WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ubiquitin ligase complex [GO:0000151]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9H7D7-1; Sequence=Displayed; Name=2; IsoId=Q9H7D7-2; Sequence=VSP_023895; Note=No experimental confirmation available.; Name=3; IsoId=Q9H7D7-3; Sequence=VSP_023896, VSP_023898; Note=No experimental confirmation available.; Name=4; IsoId=Q9H7D7-4; Sequence=VSP_023897, VSP_023899; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15378603}. Nucleus {ECO:0000269|PubMed:29911972}. Mitochondrion {ECO:0000250|UniProtKB:F1LTR1}.


uniprotID: Q9H7M9
geneSymbol: VSIR
length: 311
go: ENSG00000107738;
snps: rs3747869
name:
V-type immunoglobulin domain-containing suppressor of T-cell activation (Platelet receptor Gi24) (Stress-induced secreted protein-1) (Sisp-1) (V-set domain-containing immunoregulatory receptor) (V-set immunoregulatory receptor)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; endopeptidase activator activity [GO:0061133]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000565]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of tumor necrosis factor production [GO:0032720]; positive regulation of cell migration [GO:0030335]; positive regulation of collagen catabolic process [GO:0120158]; positive regulation of endopeptidase activity [GO:0010950]; positive regulation of gene expression [GO:0010628]; positive regulation of regulatory T cell differentiation [GO:0045591]; zymogen activation [GO:0031638]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20666777, ECO:0000269|PubMed:24691993}; Single-pass type I membrane protein {ECO:0000255}.


uniprotID: Q3ZAQ7
geneSymbol: VMA21
length: 101
go: ENSG00000160131;
name:
Vacuolar ATPase assembly integral membrane protein VMA21 (Myopathy with excessive autophagy protein)

sequence:
MERPDKAALNALQPPEFRNESSLASTLKTLLFFTALMITVPIGLYFTTKSYIFEGALGMSNRDSYFYAAIVAVVAVHVVLALFVYVAWNEGSRQWREGKQD

opentargets:
endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; ER to Golgi transport vesicle membrane [GO:0012507]; integral component of membrane [GO:0016021]; lysosome [GO:0005764]; regulation of ATPase activity [GO:0043462]; vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q3ZAQ7-1; Sequence=Displayed; Name=2; IsoId=Q3ZAQ7-2; Sequence=VSP_041257; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691, ECO:0000269|PubMed:23315026}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691, ECO:0000269|PubMed:23315026}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000255|HAMAP-Rule:MF_03058, ECO:0000269|PubMed:19379691, ECO:0000269|PubMed:23315026}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}.


uniprotID: Q2NL98
geneSymbol: VMAC
name: Vimentin-type intermediate filament-associated coiled-coil protein
length: 169
go: ENSG00000187650;
opentargets: cytoplasm [GO:0005737]; type III intermediate filament [GO:0045098]
sequence:
MSAPPALQIREANAHLAAVHRRAAELEARLDAAERTVHAQAERLALHDQQLRAALDELGRAKDREIATLQEQLMTSEATVHSLQATVHQRDELIRQLQPRAELLQDICRRRPPLAGLLDALAEAERLGPLPASDPGHPPPGGPGPPLDNSTGEEADRDHLQPAVFGTTV

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes with vimentin-type intermediate filaments. {ECO:0000250}.


uniprotID: Q96GC9
geneSymbol: VMP1
name: Vacuole membrane protein 1 (Transmembrane protein 49)
length: 406
go: ENSG00000062716;
sequence:

opentargets:
autophagosome membrane [GO:0000421]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; integral component of membrane [GO:0016021]; nucleolus [GO:0005730]; phagophore assembly site [GO:0000407]; plasma membrane [GO:0005886]; autophagosome assembly [GO:0000045]; cell junction assembly [GO:0034329]; cell-cell adhesion [GO:0098609]; embryo implantation [GO:0007566]; endoplasmic reticulum organization [GO:0007029]; exocytosis [GO:0006887]; Golgi organization [GO:0007030]; macroautophagy [GO:0016236]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GC9-1; Sequence=Displayed; Name=2; IsoId=Q96GC9-2; Sequence=VSP_056106; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17724469}; Multi-pass membrane protein {ECO:0000255}. Vacuole membrane {ECO:0000250|UniProtKB:Q91ZQ0}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:17724469}.


uniprotID: Q8NFZ6
geneSymbol: VN1R2
name: Vomeronasal type-1 receptor 2 (G-protein coupled receptor GPCR25) (hGPCR25) (V1r-like receptor 2)
length: 395
snps: rs2965249
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]


uniprotID: Q9BXE9
geneSymbol: VN1R3
name: Vomeronasal type-1 receptor 3 (V1r-like receptor 3)
length: 311
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q7Z5H5
geneSymbol: VN1R4
name: Vomeronasal type-1 receptor 4 (G-protein coupled receptor GPCR27) (hGPCR27) (V1r-like receptor 4)
length: 301
snps: rs74429916 rs12977715
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q7Z5H4
geneSymbol: VN1R5
name: Vomeronasal type-1 receptor 5 (G-protein coupled receptor GPCR26) (hGPCR26) (V1r-like receptor 5)
length: 357
snps: rs41308154
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:


uniprotID: Q9NY84
geneSymbol: VNN3
reactome: R-HSA-163125;
name: Vascular non-inflammatory molecule 3 (Vanin-3) (EC 3.5.1.92)
length: 501
go: ENSG00000093134;
snps: rs764264 rs36012859 rs12174042 rs6569834
sequence:

opentargets:
anchored component of membrane [GO:0031225]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; pantetheine hydrolase activity [GO:0017159]; pantothenate metabolic process [GO:0015939]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q9NY84-1; Sequence=Displayed; Name=2; Synonyms=PAGEL-gamma; IsoId=Q9NY84-2; Sequence=VSP_017138, VSP_017139; Note=Expressed in neutrophils, this isoform displays a frameshift at Glu-227 due to one missing nucleotide compared to isoform 1, this missing nucleotide could be a variation as it is also present on genomic sequence.; Name=3; Synonyms=PAGEL-alpha; IsoId=Q9NY84-3; Sequence=VSP_029578, VSP_029579; Name=4; Synonyms=PAGEL-beta; IsoId=Q9NY84-4; Sequence=VSP_038563, VSP_038567; Name=5; Synonyms=PAGEL-delta; IsoId=Q9NY84-5; Sequence=VSP_038568, VSP_038569; Name=6; Synonyms=PAGEL-epsilon; IsoId=Q9NY84-6; Sequence=VSP_038562, VSP_038566; Name=7; Synonyms=PAGEL-zeta; IsoId=Q9NY84-7; Sequence=VSP_038564, VSP_038565; Name=8; Synonyms=PAGEL-eta; IsoId=Q9NY84-8; Sequence=VSP_038561, VSP_038564, VSP_038565; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}. Note=According to PubMed:11491533, secreted. {ECO:0000250}.


uniprotID: Q96RL7
geneSymbol: VPS13A
name: Vacuolar protein sorting-associated protein 13A (Chorea-acanthocytosis protein) (Chorein)
length: 3174
go: ENSG00000197969;
snps: rs119477052 rs78048112 rs76077278 rs149840356 rs41289969 rs141138349 rs781395681 rs75740713
sequence:

opentargets:
cytosol [GO:0005829]; dense core granule [GO:0031045]; extrinsic component of membrane [GO:0019898]; intracellular [GO:0005622]; autophagy [GO:0006914]; Golgi to endosome transport [GO:0006895]; locomotory behavior [GO:0007626]; nervous system development [GO:0007399]; protein localization [GO:0008104]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]; social behavior [GO:0035176]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=A; IsoId=Q96RL7-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q96RL7-2; Sequence=VSP_006550; Name=3; Synonyms=Chorein 2A; IsoId=Q96RL7-3; Sequence=VSP_014904; Name=4; Synonyms=Chorein 1D; IsoId=Q96RL7-4; Sequence=VSP_014905, VSP_014906; 


uniprotID: Q6ZV60
geneSymbol: LINC00173
name: Putative uncharacterized protein encoded by LINC00173
length: 143
sequence:
MSFSPYSTMITVCVCFNSRVQLTVPSFTAWLRSRYSKALFMVLRRAAQEKDKGVCQGWHCVKKWACKGRIPGQPLQPQPLGPYLRSLSQHPATQTPRPQARASSRYLELHRSQNRGGSEFKFWFCYCLIACCRDSISSSGKWE


uniprotID: P63127
geneSymbol: ERVK-9
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 9 Pro protein (HERV-K(C6) Pro protein) (HERV-K109 Pro protein) (HERV-K_6q14.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKRGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63127-1; Sequence=Displayed; 


uniprotID: Q99986
geneSymbol: VRK1
reactome: R-HSA-2993913;R-HSA-2995383;
pdb: 2KTY;2KUL;2LAV;2RSV;3OP5;5UKF;5UVF;6BP0;6BRU;6BTW;6BU6;6CFM;6CMM;6CNX;6CQH;6CSW;6DD4;
name: Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)
length: 396
go: ENSG00000100749;
sequence:

opentargets:
cytosol [GO:0005829]; Golgi stack [GO:0005795]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; ATP binding [GO:0005524]; histone kinase activity (H3-S10 specific) [GO:0035175]; histone kinase activity (H3-T3 specific) [GO:0072354]; nucleosomal histone binding [GO:0031493]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; cell division [GO:0051301]; Golgi disassembly [GO:0090166]; histone H3-S10 phosphorylation [GO:0043987]; histone H3-T3 phosphorylation [GO:0072355]; mitotic nuclear envelope disassembly [GO:0007077]; mitotic nuclear envelope reassembly [GO:0007084]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.


uniprotID: O60504
geneSymbol: SORBS3
reactome: R-HSA-445355;
pdb: 2CT3;2DLM;2NWM;2YUP;
name: Vinexin (SH3-containing adapter molecule 1) (SCAM-1) (Sorbin and SH3 domain-containing protein 3)
length: 671
go: ENSG00000120896;
snps: rs3758036 rs2449331 rs1047030
sequence:

opentargets:
cytoskeleton [GO:0005856]; cytosol [GO:0005829]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; structural constituent of cytoskeleton [GO:0005200]; transcription factor binding [GO:0008134]; vinculin binding [GO:0017166]; actin filament organization [GO:0007015]; cell adhesion [GO:0007155]; cell-substrate adhesion [GO:0031589]; muscle contraction [GO:0006936]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoskeleton organization [GO:0051495]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of stress fiber assembly [GO:0051496]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Alpha; IsoId=O60504-1; Sequence=Displayed; Name=Beta; IsoId=O60504-2; Sequence=VSP_004489; 

location:
SUBCELLULAR LOCATION: Isoform Alpha: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform Beta: Cell junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus. {ECO:0000250}.


uniprotID: Q9Y2B5
geneSymbol: VPS9D1
name: VPS9 domain-containing protein 1 (Protein ATP-BL)
length: 631
go: ENSG00000075399;
sequence:

opentargets:
GTPase activator activity [GO:0005096]; transporter activity [GO:0005215]; ATP synthesis coupled proton transport [GO:0015986]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2B5-1; Sequence=Displayed; Name=2; IsoId=Q9Y2B5-2; Sequence=VSP_040306; Note=No experimental confirmation available.; 


uniprotID: Q9Y487
geneSymbol: ATP6V0A2
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 856
go: ENSG00000185344;
snps: rs7969410 rs17883456
name:
V-type proton ATPase 116 kDa subunit a isoform 2 (V-ATPase 116 kDa isoform a2) (Lysosomal H(+)-transporting ATPase V0 subunit a2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)

sequence:

opentargets:
acrosomal vesicle [GO:0001669]; endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular iron ion homeostasis [GO:0006879]; cellular response to increased oxygen levels [GO:0036295]; immune response [GO:0006955]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]; vacuolar acidification [GO:0007035]

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles. {ECO:0000250}.


uniprotID: Q9HAV4
geneSymbol: XPO5
reactome: R-HSA-203927;
pdb: 3A6P;5YU6;5YU7;
name: Exportin-5 (Exp5) (Ran-binding protein 21)
length: 1204
go: ENSG00000124571;
snps: rs34324334 rs11544379 rs12173786
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; micro-ribonucleoprotein complex [GO:0035068]; nuclear RNA export factor complex [GO:0042272]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA nuclear export complex [GO:0042565]; mRNA binding [GO:0003729]; nuclear export signal receptor activity [GO:0005049]; pre-miRNA binding [GO:0070883]; protein transporter activity [GO:0008565]; Ran GTPase binding [GO:0008536]; RNA binding [GO:0003723]; tRNA binding [GO:0000049]; miRNA metabolic process [GO:0010586]; positive regulation of RNA interference [GO:1900370]; pre-miRNA export from nucleus [GO:0035281]; protein export from nucleus [GO:0006611]; regulation of protein export from nucleus [GO:0046825]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11777942}. Cytoplasm {ECO:0000269|PubMed:11777942}. Note=Shuttles between the nucleus and the cytoplasm.


uniprotID: P12018
geneSymbol: VPREB1
reactome: R-HSA-202733;
pdb: 2H32;2H3N;3BJ9;
length: 145
go: ENSG00000169575;
snps: rs1320 rs11089979 rs5995720
name:
Immunoglobulin iota chain (CD179 antigen-like family member A) (Protein VPreB1) (V(pre)B protein) (VpreB protein) (CD antigen CD179a)

sequence:
MSWAPVLLMLFVYCTGCGPQPVLHQPPAMSSALGTTIRLTCTLRNDHDIGVYSVYWYQQRPGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSISELQPEDEAMYYCAMGARSSEKEEREREWEEEMEPTAARTRVP

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; immune response [GO:0006955]; immunoglobulin production [GO:0002377]; leukocyte migration [GO:0050900]


uniprotID: P63131
geneSymbol: ERVK-7
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 7 Pro protein (HERV-K(III) Pro protein) (HERV-K102 Pro protein) (HERV-K_1q22 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQEREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63131-1; Sequence=Displayed; 


uniprotID: A5D8V6
geneSymbol: VPS37C
reactome: R-HSA-162588;R-HSA-174490;R-HSA-917729;
name: Vacuolar protein sorting-associated protein 37C (hVps37C) (ESCRT-I complex subunit VPS37C)
length: 355
go: ENSG00000167987;
snps: rs2232142 rs754382
sequence:

opentargets:
endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; calcium-dependent protein binding [GO:0048306]; endosomal transport [GO:0016197]; endosome transport via multivesicular body sorting pathway [GO:0032509]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; protein transport [GO:0015031]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000305|PubMed:15509564}; Peripheral membrane protein {ECO:0000305|PubMed:15509564}. Note=Probably associates with membranes. Recruited to the plasma membrane by HIV-1.


uniprotID: Q8N3P4
geneSymbol: VPS8
name: Vacuolar protein sorting-associated protein 8 homolog
length: 1428
go: ENSG00000156931;
snps: rs9830734 rs11555405 rs3821750 rs16859527
location: SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:25266290}.
sequence:

opentargets:
CORVET complex [GO:0033263]; early endosome [GO:0005769]; metal ion binding [GO:0046872]; endosomal vesicle fusion [GO:0034058]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N3P4-1; Sequence=Displayed; Name=2; IsoId=Q8N3P4-2; Sequence=VSP_023249, VSP_023250; Name=3; IsoId=Q8N3P4-3; Sequence=VSP_023249; Note=No experimental confirmation available.; 


uniprotID: Q86VN1
geneSymbol: VPS36
reactome: R-HSA-917729;
pdb: 2HTH;2ZME;3CUQ;
length: 386
go: ENSG00000136100;
name:
Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36)

sequence:

opentargets:
cytosol [GO:0005829]; endosome [GO:0005768]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; nucleus [GO:0005634]; phosphatidylinositol-3-phosphate binding [GO:0032266]; protein C-terminus binding [GO:0008022]; ubiquitin binding [GO:0043130]; endosomal transport [GO:0016197]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86VN1-1; Sequence=Displayed; Name=2; IsoId=Q86VN1-2; Sequence=VSP_015342; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Endosome. Late endosome {ECO:0000250|UniProtKB:Q91XD6}. Membrane. Nucleus {ECO:0000305}. Note=Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250|UniProtKB:Q91XD6}.


uniprotID: Q9P253
geneSymbol: VPS18
name: Vacuolar protein sorting-associated protein 18 homolog (hVPS18)
length: 973
go: ENSG00000104142;
sequence:

opentargets:
actin filament [GO:0005884]; AP-3 adaptor complex [GO:0030123]; autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; CORVET complex [GO:0033263]; early endosome [GO:0005769]; endosome [GO:0005768]; glutamatergic synapse [GO:0098978]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; presynapse [GO:0098793]; actin binding [GO:0003779]; metal ion binding [GO:0046872]; protein binding, bridging [GO:0030674]; syntaxin binding [GO:0019905]; autophagy [GO:0006914]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; regulation of SNARE complex assembly [GO:0035542]; regulation of synaptic vesicle exocytosis [GO:2000300]; vesicle docking involved in exocytosis [GO:0006904]; viral entry into host cell [GO:0046718]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:11382755}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:11382755}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:18552835}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}. Note=Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.


uniprotID: O15537
geneSymbol: RS1
pdb: 3JD6;5N6W;
name: Retinoschisin (X-linked juvenile retinoschisis protein)
length: 224
go: ENSG00000102104;
sequence:

opentargets:
extracellular space [GO:0005615]; extrinsic component of plasma membrane [GO:0019897]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; phosphatidylserine binding [GO:0001786]; adaptation of rhodopsin mediated signaling [GO:0016062]; cell adhesion [GO:0007155]; multicellular organism development [GO:0007275]; protein homooligomerization [GO:0051260]; retina layer formation [GO:0010842]; visual perception [GO:0007601]

snps:
rs62645879 rs104894935 rs62645889 rs62645892 rs62645894 rs104894932 rs104894928 rs62645899 rs104894933 rs61752060 rs61752063 rs61752065 rs61752068 rs61752067 rs61752069 rs61752072 rs281865345 rs104894934 rs104894934 rs61752075 rs61752144 rs61752145 rs61752149 rs61752152 rs61752153 rs61752154 rs61752157 rs61752156 rs61752158 rs61752158 rs61752159 rs1800001 rs61753161 rs61753163 rs61753162 rs61753165 rs1800002 rs61753166 rs61753169 rs61753171 rs61753175 rs61753174 rs281865352 rs281865351 rs281865354 rs281865355 rs281865356 rs281865357 rs281865358 rs104894930 rs281865360 rs281865361 rs281865362 rs281865364 rs281865365 rs281865367 rs281865367 rs281865368 rs281865369 rs281865369 rs1800004 rs104894929 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10915776, ECO:0000269|PubMed:19849666, ECO:0000269|PubMed:26812435}. Cell membrane {ECO:0000250|UniProtKB:Q9Z1L4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z1L4}; Extracellular side {ECO:0000250|UniProtKB:Q9Z1L4}. Note=Binds to phosphatidylserine-containing lipid membranes and embeds itself partially into the lipid bilayer. Lipid-binding requires the presence of Ca(2+) ions. {ECO:0000250|UniProtKB:Q9Z1L4}.


uniprotID: Q5T9L3
geneSymbol: WLS
reactome: R-HSA-3238698;
length: 541
go: ENSG00000116729;
snps: rs983034
name:
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)

sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; dendrite cytoplasm [GO:0032839]; dendrite membrane [GO:0032590]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; trans-Golgi network [GO:0005802]; mu-type opioid receptor binding [GO:0031852]; Wnt-protein binding [GO:0017147]; anterior/posterior axis specification [GO:0009948]; exocrine pancreas development [GO:0031017]; hindbrain development [GO:0030902]; intracellular protein transport [GO:0006886]; mesoderm formation [GO:0001707]; midbrain development [GO:0030901]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of Wnt protein secretion [GO:0061357]; positive regulation of Wnt signaling pathway [GO:0030177]; Wnt protein secretion [GO:0061355]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5T9L3-1; Sequence=Displayed; Name=2; IsoId=Q5T9L3-2; Sequence=VSP_022346, VSP_022347; Name=3; IsoId=Q5T9L3-3; Sequence=VSP_046143; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16678095}; Multi-pass membrane protein {ECO:0000269|PubMed:16678095}. Cell membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18160347}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with the adaptin AP2A2 at distinct punctae. {ECO:0000269|PubMed:18160347}.


uniprotID: P10265
geneSymbol: ERVK-10
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 10 Pro protein (HERV-K10 Pro protein) (HERV-K107 Pro protein) (HERV-K_5q33.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQEREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P10265-1; Sequence=Displayed; 


uniprotID: Q9NRW7
geneSymbol: VPS45
reactome: R-HSA-6811438;R-HSA-983231;
name: Vacuolar protein sorting-associated protein 45 (h-VPS45) (hlVps45)
length: 570
go: ENSG00000136631;
snps: rs879255237 rs782269909
sequence:

opentargets:
endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; synaptic vesicle [GO:0008021]; blood coagulation [GO:0007596]; intracellular protein transport [GO:0006886]; vesicle docking involved in exocytosis [GO:0006904]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NRW7-1; Sequence=Displayed; Name=2; IsoId=Q9NRW7-2; Sequence=VSP_056739, VSP_056740, VSP_056741; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Associated with Golgi/endosomal vesicles and the trans-Golgi network. {ECO:0000250}.


uniprotID: P63122
geneSymbol: ERVK-8
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 8 Pro protein (HERV-K115 Pro protein) (HERV-K_8p23.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVIGLVGIGTASEVYQSMEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKRGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63122-1; Sequence=Displayed; 


uniprotID: P0DPA2
geneSymbol: VSIG8
name: V-set and immunoglobulin domain-containing protein 8
length: 414
go: ENSG00000243284;
opentargets: integral component of membrane [GO:0016021]; intracellular [GO:0005622]; RNA binding [GO:0003723]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8IV63
geneSymbol: VRK3
reactome: R-HSA-202670;
pdb: 2JII;
length: 474
go: ENSG00000105053;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14645249}.
name:
Inactive serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3)

sequence:

opentargets:
intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein phosphatase binding [GO:0019903]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of phosphoprotein phosphatase activity [GO:0032516]

snps:
rs2033262 rs11547882 rs11547881 rs11547883 rs11879620 rs10410075 rs10409482 rs35261919 rs35331034 rs56407496 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IV63-1; Sequence=Displayed; Name=2; IsoId=Q8IV63-2; Sequence=VSP_008544, VSP_008545; Note=No experimental confirmation available.; Name=3; IsoId=Q8IV63-3; Sequence=VSP_043409; Note=No experimental confirmation available.; 


uniprotID: Q8N1B4
geneSymbol: VPS52
reactome: R-HSA-6811440;
length: 723
go: ENSG00000223501;
name:
Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)

sequence:

opentargets:
cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]; Rab GTPase binding [GO:0017137]; syntaxin binding [GO:0019905]; ectodermal cell differentiation [GO:0010668]; embryonic ectodermal digestive tract development [GO:0048611]; endocytic recycling [GO:0032456]; Golgi to vacuole transport [GO:0006896]; lysosomal transport [GO:0007041]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N1B4-1; Sequence=Displayed; Name=2; IsoId=Q8N1B4-2; Sequence=VSP_056476; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.


uniprotID: Q5VIR6
geneSymbol: VPS53
reactome: R-HSA-6811440;
name: Vacuolar protein sorting-associated protein 53 homolog
length: 699
go: ENSG00000141252;
snps: rs16954056 rs61644407 rs587777465
sequence:

opentargets:
cytosol [GO:0005829]; EARP complex [GO:1990745]; endosome membrane [GO:0010008]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; recycling endosome [GO:0055037]; trans-Golgi network membrane [GO:0032588]; endocytic recycling [GO:0032456]; lysosomal transport [GO:0007041]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=long; IsoId=Q5VIR6-1; Sequence=Displayed; Name=2; Synonyms=short; IsoId=Q5VIR6-2; Sequence=VSP_016236; Name=3; IsoId=Q5VIR6-3; Sequence=VSP_016237, VSP_016238; Note=No experimental confirmation available.; Name=4; IsoId=Q5VIR6-4; Sequence=VSP_042106; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Endosome membrane {ECO:0000269|PubMed:18367545}; Peripheral membrane protein. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.


uniprotID: Q13488
geneSymbol: TCIRG1
reactome: R-HSA-1222556;R-HSA-6798695;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 830
go: ENSG00000110719;
snps: rs36027301 rs34227834 rs137853150 rs137853151 rs369264588
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
name:
V-type proton ATPase 116 kDa subunit a isoform 3 (V-ATPase 116 kDa isoform a3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; endosome membrane [GO:0010008]; ficolin-1-rich granule membrane [GO:0101003]; integral component of plasma membrane [GO:0005887]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; transporter activity [GO:0005215]; ATP hydrolysis coupled proton transport [GO:0015991]; cellular defense response [GO:0006968]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; macroautophagy [GO:0016236]; neutrophil degranulation [GO:0043312]; positive regulation of cell proliferation [GO:0008284]; protein catabolic process in the vacuole [GO:0007039]; proton transmembrane transport [GO:1902600]; transferrin transport [GO:0033572]; vacuolar acidification [GO:0007035]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=Q13488-1; Sequence=Displayed; Name=Short; IsoId=Q13488-2; Sequence=VSP_000345; Note=No experimental confirmation available.; 


uniprotID: Q93050
geneSymbol: ATP6V0A1
reactome: R-HSA-1222556;R-HSA-6798695;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 837
go: ENSG00000033627;
name:
V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)

sequence:

opentargets:
cytosol [GO:0005829]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; melanosome [GO:0042470]; nuclear speck [GO:0016607]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220]; ATPase binding [GO:0051117]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; neutrophil degranulation [GO:0043312]; regulation of macroautophagy [GO:0016241]; toxin transport [GO:1901998]; transferrin transport [GO:0033572]; vacuolar acidification [GO:0007035]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=I; IsoId=Q93050-2; Sequence=Displayed; Name=2; Synonyms=II; IsoId=Q93050-1; Sequence=VSP_012814; Name=3; IsoId=Q93050-3; Sequence=VSP_043532, VSP_012814; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Melanosome. Note=Coated vesicle. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.


uniprotID: Q96JC1
geneSymbol: VPS39
name: Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p)
length: 886
go: ENSG00000166887;
sequence:

opentargets:
AP-3 adaptor complex [GO:0030123]; HOPS complex [GO:0030897]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; retrograde transport, endosome to plasma membrane [GO:1990126]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96JC1-1; Sequence=Displayed; Name=2; IsoId=Q96JC1-2; Sequence=VSP_004075; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Lysosome membrane {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Late endosome membrane {ECO:0000269|PubMed:11448994}; Peripheral membrane protein {ECO:0000305|PubMed:11448994}. Late endosome {ECO:0000269|PubMed:23167963}. Lysosome {ECO:0000269|PubMed:23167963}. Note=Colocalizes with TGFBR1 and TGFBR2 in cytoplasmic vesicular structures and most prominently in cortical vesicles. {ECO:0000269|PubMed:12941698}.


uniprotID: A6NGB9
geneSymbol: WIPF3
reactome: R-HSA-2029482;R-HSA-5663213;
length: 483
go: ENSG00000122574;
snps: rs3750092
name:
WAS/WASL-interacting protein family member 3 (Corticosteroids and regional expression protein 16 homolog)

sequence:

opentargets:
actin cortical patch [GO:0030479]; actin filament [GO:0005884]; cytosol [GO:0005829]; actin filament binding [GO:0051015]; SH3 domain binding [GO:0017124]; actin cortical patch assembly [GO:0000147]; actin cortical patch localization [GO:0051666]; actin filament-based movement [GO:0030048]; cell differentiation [GO:0030154]; endocytosis [GO:0006897]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; multicellular organism development [GO:0007275]; positive regulation of actin nucleation [GO:0051127]; spermatogenesis [GO:0007283]

location:
SUBCELLULAR LOCATION: Cytoplasm. Note=In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone. {ECO:0000250}.


uniprotID: Q9BRG1
geneSymbol: VPS25
reactome: R-HSA-917729;
pdb: 2ZME;3CUQ;3HTU;
length: 176
go: ENSG00000131475;
snps: rs34494804
name:
Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25)

sequence:
MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLFNNVKLQRKLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQNNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT II complex [GO:0000814]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein homodimerization activity [GO:0042803]; protein N-terminus binding [GO:0047485]; structural molecule activity [GO:0005198]; endosomal transport [GO:0016197]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; negative regulation of epidermal growth factor-activated receptor activity [GO:0007175]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]

location:
SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Note=Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6.


uniprotID: Q86VR7
geneSymbol: VSIG10L
name: V-set and immunoglobulin domain-containing protein 10-like (VSIG10-like protein)
length: 867
go: ENSG00000186806;
opentargets: integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
snps: rs10414211 rs7259266 rs34380065 rs57710066 rs1263178238 rs377207472
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86VR7-1; Sequence=Displayed; Name=2; IsoId=Q86VR7-2; Sequence=VSP_039374; Note=No experimental confirmation available.; 


uniprotID: P49754
geneSymbol: VPS41
name: Vacuolar protein sorting-associated protein 41 homolog (S53)
length: 854
go: ENSG00000006715;
snps: rs35693565 rs11762417 rs1059508
sequence:

opentargets:
AP-3 adaptor complex [GO:0030123]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; Golgi-associated vesicle [GO:0005798]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; microtubule binding [GO:0008017]; protein self-association [GO:0043621]; autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome to lysosome transport [GO:0008333]; Golgi vesicle transport [GO:0048193]; intracellular protein transport [GO:0006886]; late endosome to lysosome transport [GO:1902774]; regulated exocytosis [GO:0045055]; regulation of SNARE complex assembly [GO:0035542]; vacuole fusion, non-autophagic [GO:0042144]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P49754-1; Sequence=Displayed; Name=2; IsoId=P49754-2; Sequence=VSP_006751, VSP_006752; Name=3; IsoId=P49754-3; Sequence=VSP_054169; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:25445562}. Late endosome {ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:23322049}. Lysosome {ECO:0000269|PubMed:23167963}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23322049}. Early endosome {ECO:0000269|PubMed:21411634}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21411634}.


uniprotID: P19544
geneSymbol: WT1
name: Wilms tumor protein (WT33)
length: 449
go: ENSG00000184937;
snps: rs2234584 rs121907908
pdb:
1LU6;1XF7;2G7T;2G7V;2G7W;2G7X;2JP9;2JPA;2PRT;3HPJ;3MYJ;4R2E;4R2P;4R2Q;4R2R;4R2S;4WUU;5KL2;5KL3;5KL4;5KL5;5KL6;5KL7;6B0O;6B0P;6B0Q;6B0R;6BLW;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; C2H2 zinc finger domain binding [GO:0070742]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded methylated DNA binding [GO:0010385]; hemi-methylated DNA-binding [GO:0044729]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region DNA binding [GO:0044212]; zinc ion binding [GO:0008270]; adrenal cortex formation [GO:0035802]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; camera-type eye development [GO:0043010]; cardiac muscle cell fate commitment [GO:0060923]; cellular response to cAMP [GO:0071320]; cellular response to gonadotropin stimulus [GO:0071371]; diaphragm development [GO:0060539]; epithelial cell differentiation [GO:0030855]; germ cell development [GO:0007281]; glomerular basement membrane development [GO:0032836]; glomerular visceral epithelial cell differentiation [GO:0072112]; glomerulus development [GO:0032835]; gonad development [GO:0008406]; heart development [GO:0007507]; kidney development [GO:0001822]; male genitalia development [GO:0030539]; male gonad development [GO:0008584]; mesenchymal to epithelial transition [GO:0060231]; metanephric epithelium development [GO:0072207]; metanephric mesenchyme development [GO:0072075]; metanephric S-shaped body morphogenesis [GO:0072284]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of female gonad development [GO:2000195]; negative regulation of metanephric glomerular mesangial cell proliferation [GO:0072302]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]; positive regulation of apoptotic process [GO:0043065]; positive regulation of DNA methylation [GO:1905643]; positive regulation of gene expression [GO:0010628]; positive regulation of heart growth [GO:0060421]; positive regulation of male gonad development [GO:2000020]; positive regulation of metanephric ureteric bud development [GO:2001076]; positive regulation of pri-miRNA transcription by RNA polymerase II [GO:1902895]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; posterior mesonephric tubule development [GO:0072166]; regulation of animal organ formation [GO:0003156]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; RNA splicing [GO:0008380]; sex determination [GO:0007530]; thorax and anterior abdomen determination [GO:0007356]; tissue development [GO:0009888]; ureteric bud development [GO:0001657]; vasculogenesis [GO:0001570]; visceral serous pericardium development [GO:0061032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=8;  Name=1; IsoId=P19544-1; Sequence=Displayed; Note=Detected in nucleus speckle, may bind mRNA.; Name=2; IsoId=P19544-2; Sequence=VSP_006866, VSP_006867; Name=3; IsoId=P19544-3; Sequence=VSP_006866; Name=4; IsoId=P19544-4; Sequence=VSP_006867; Name=6; IsoId=P19544-6; Sequence=VSP_037582, VSP_037584, VSP_006867; Name=7; IsoId=P19544-7; Sequence=VSP_037583; Note=Produced by alternative initiation of isoform 1. Extended N-terminus.; Name=8; IsoId=P19544-8; Sequence=VSP_037583, VSP_006866; Note=Produced by alternative initiation of isoform 1. Extended N-terminus.; Name=9; IsoId=P19544-9; Sequence=VSP_037582, VSP_037584, VSP_006866; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15520190}. Nucleus, nucleolus. Cytoplasm {ECO:0000250}. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:15520190}.; SUBCELLULAR LOCATION: Isoform 1: Nucleus speckle {ECO:0000269|PubMed:15520190}.; SUBCELLULAR LOCATION: Isoform 4: Nucleus, nucleoplasm {ECO:0000269|PubMed:15520190}.


uniprotID: A8MUN3
name: Putative uncharacterized protein ENSP00000381830
length: 132
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MSFEYRHYKREAKICTCRGGWAHVLLCIGVSQGACAEHLPHRPAVEKDVPGAGEVLFMCSWRIFPVASASPSSSISGLAGHSVFLVPGLAAHPGSHSDQPPGVPSRRKSRLERWSPSVSRSTSPPTEAPFCL


uniprotID: Q6UXP9
name: Putative uncharacterized protein UNQ9370/PRO34162
length: 181
sequence:
MIFMQILEPQEVPSFLMICQRRSPAMHRTCTDHAPLAIAQVWLWVSLAKAGSNRRGPGRAEGTFFSLLAALHAAQHFPNLPTAPGGASQSNIVSPELTPKPTTALKHAECLLDLNSHSLYRKPRPKAAVYLNLSLPLKSVHRLSLKKSFGFGKRDFENNSVFIVDSGGTCAGLLPGYIGWC


uniprotID: Q9UIJ5
geneSymbol: ZDHHC2
reactome: R-HSA-5683826;
length: 367
go: ENSG00000104219;
snps: rs568589179
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; cellular protein metabolic process [GO:0044267]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]


uniprotID: Q9NQX6
geneSymbol: ZNF331
reactome: R-HSA-212436;
length: 463
go: ENSG00000130844;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 331 (C2H2-like zinc finger protein rearranged in thyroid adenomas) (Zinc finger protein 361) (Zinc finger protein 463)

sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]


uniprotID: A8MUU9
name: Putative uncharacterized protein ENSP00000383309
length: 505
sequence:


uniprotID: Q8TAD4
geneSymbol: SLC30A5
reactome: R-HSA-264876;R-HSA-435368;
name: Zinc transporter 5 (ZnT-5) (Solute carrier family 30 member 5) (ZnT-like transporter 1) (hZTL1)
length: 765
go: ENSG00000145740;
sequence:

opentargets:
apical plasma membrane [GO:0016324]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; zinc ion binding [GO:0008270]; zinc ion transmembrane transporter activity [GO:0005385]; cellular zinc ion homeostasis [GO:0006882]; cobalt ion transport [GO:0006824]; regulation of proton transport [GO:0010155]; response to zinc ion [GO:0010043]; zinc ion transport [GO:0006829]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8TAD4-1; Sequence=Displayed; Name=2; IsoId=Q8TAD4-2; Sequence=VSP_030254, VSP_030255, VSP_030256; Name=3; IsoId=Q8TAD4-3; Sequence=VSP_043673, VSP_043674; Note=No experimental confirmation available.; Name=4; IsoId=Q8TAD4-4; Sequence=VSP_045115, VSP_043673, VSP_043674; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:15525635}; Multi-pass membrane protein {ECO:0000269|PubMed:11904301, ECO:0000269|PubMed:11937503, ECO:0000269|PubMed:15525635}. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.


uniprotID: Q6ZTK2
name: Putative uncharacterized protein LOC400499
length: 550
snps: rs8050530 rs7206698 rs12932948 rs12933868 rs13337464 rs4467099 rs4238608
sequence:


uniprotID: O60688
geneSymbol: YPEL1
name: Protein yippee-like 1
length: 119
go: ENSG00000100027;
opentargets: nucleus [GO:0005634]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:
MVKMTKSKTFQAYLPNCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKFIIELAHMIKDNGWE


uniprotID: Q8NC26
geneSymbol: ZNF114
reactome: R-HSA-212436;
name: Zinc finger protein 114
length: 417
go: ENSG00000178150;
snps: rs35802964 rs16981956
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NC26-1; Sequence=Displayed; Name=2; IsoId=Q8NC26-2; Sequence=VSP_024864; Note=No experimental confirmation available.; 


uniprotID: Q96NC0
geneSymbol: ZMAT2
pdb: 5O9Z;
name: Zinc finger matrin-type protein 2
length: 199
go: ENSG00000146007;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28781166}.
sequence:
MASGSGTKNLDFRRKWDKDEYEKLAEKRLTEEREKKDGKPVQPVKRELLRHRDYKVDLESKLGKTIVITKTTPQSEMGGYYCNVCDCVVKDSINFLDHINGKKHQRNLGMSMRVERSTLDQVKKRFEVNKKKMEEKQKDYDFEERMKELREEEEKAKAYKKEKQKEKKRRAEEDLTFEEDDEMAAVMGFSGFGSTKKSY

opentargets:
nucleus [GO:0005634]; U2-type precatalytic spliceosome [GO:0071005]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; mRNA splicing, via spliceosome [GO:0000398]


uniprotID: Q9Y4E5
geneSymbol: ZNF451
pdb: 5D2M;
length: 1061
go: ENSG00000112200;
name:
E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)

sequence:

opentargets:
nucleus [GO:0005634]; PML body [GO:0016605]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; SUMO ligase activity [GO:0061665]; transcription corepressor activity [GO:0003714]; negative regulation of histone H3-K9 acetylation [GO:2000616]; negative regulation of transcription initiation from RNA polymerase II promoter [GO:0060633]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; protein sumoylation [GO:0016925]; regulation of gene expression [GO:0010468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y4E5-1; Sequence=Displayed; Name=2; IsoId=Q9Y4E5-2; Sequence=VSP_008624; Name=3; IsoId=Q9Y4E5-4; Sequence=VSP_035312; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18656483, ECO:0000269|PubMed:24324267}. Nucleus, PML body {ECO:0000269|PubMed:18656483}. Nucleus, nucleoplasm. Note=Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location. {ECO:0000269|PubMed:18656483}.


uniprotID: Q9Y2P0
geneSymbol: ZNF835
name: Zinc finger protein 835
length: 537
go: ENSG00000127903;
snps: rs12462469 rs12460400
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription regulatory region DNA binding [GO:0044212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]


uniprotID: Q8NAQ8
name: Putative uncharacterized protein FLJ34945
length: 132
sequence:
MYSVLQLLKCLCSCWRKGPEGRRFQTEAAVCARPAWSPHPAGASEALGALPPPRQLVEKRRVSPPRRLDQSGRDGGAVAKCSLSRGLSPPGWTGRSLLRPWGSAAVLGSRAALACVLRPSRGVMPATIQSRR


uniprotID: Q9UII5
geneSymbol: ZNF107
name: Zinc finger protein 107 (Zinc finger protein 588) (Zinc finger protein ZFD25)
length: 783
go: ENSG00000196247;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q7Z7L7
geneSymbol: ZER1
name: Protein zer-1 homolog (Hzyg) (Zyg-11 homolog B-like protein) (Zyg11b-like protein)
length: 766
go: ENSG00000160445;
snps: rs13299702
sequence:

opentargets:
Cul2-RING ubiquitin ligase complex [GO:0031462]; ubiquitin-protein transferase activity [GO:0004842]; regulation of ubiquitin-protein transferase activity [GO:0051438]


uniprotID: Q8N2G6
geneSymbol: ZCCHC24
name: Zinc finger CCHC domain-containing protein 24
length: 241
go: ENSG00000165424;
opentargets: RNA binding [GO:0003723]; zinc ion binding [GO:0008270]
snps: rs17852581
sequence:


uniprotID: Q8N9K5
geneSymbol: ZNF565
reactome: R-HSA-212436;
name: Zinc finger protein 565
length: 539
go: ENSG00000196357;
snps: rs4805162
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N9K5-1; Sequence=Displayed; Name=2; IsoId=Q8N9K5-2; Sequence=VSP_055965; Note=No experimental confirmation available.; 


uniprotID: Q969W8
geneSymbol: ZNF566
reactome: R-HSA-212436;
name: Zinc finger protein 566
length: 418
go: ENSG00000186017;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969W8-1; Sequence=Displayed; Name=2; IsoId=Q969W8-2; Sequence=VSP_043419; Note=No experimental confirmation available.; 


uniprotID: Q6UXR8
name: Putative uncharacterized protein UNQ6493/PRO21345
length: 122
sequence:
MEPWWPRGTGANAPWVLVAVPPGLFPSLLGACCTLTSSSWLQPRFWGLGWRVEVGLEGAGGSSQNYQAALPSFFCLAASPASRPAIFGILAAEPPSASPQAPWPKPGCASPHGSHWPSILIC


uniprotID: Q9H6S0
geneSymbol: YTHDC2
pdb: 2YU6;
name: 3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)
length: 1430
go: ENSG00000047188;
snps: rs10071816 rs1132528
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2RR83}.
sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; ribonucleoprotein granule [GO:0035770]; 3'-5' RNA helicase activity [GO:0034458]; ATP binding [GO:0005524]; ATP-dependent 3'-5' RNA helicase activity [GO:0034459]; N6-methyladenosine-containing RNA binding [GO:1990247]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; RNA-dependent ATPase activity [GO:0008186]; germline cell cycle switching, mitotic to meiotic cell cycle [GO:0051729]; meiotic cell cycle [GO:0051321]; oocyte development [GO:0048599]; positive regulation by host of viral genome replication [GO:0044829]; response to interleukin-1 [GO:0070555]; response to tumor necrosis factor [GO:0034612]; spermatid development [GO:0007286]


uniprotID: Q6ZS27
geneSymbol: ZNF662
reactome: R-HSA-212436;
name: Zinc finger protein 662
length: 426
go: ENSG00000182983;
snps: rs60980399
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZS27-1; Sequence=Displayed; Name=2; IsoId=Q6ZS27-2; Sequence=VSP_020745; Name=3; IsoId=Q6ZS27-3; Sequence=VSP_053783, VSP_053784, VSP_053785; Note=No experimental confirmation available.; 


uniprotID: Q8NAP8
geneSymbol: ZBTB8B
name: Zinc finger and BTB domain-containing protein 8B
length: 495
go: ENSG00000254553;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NAP8-1; Sequence=Displayed; Name=2; IsoId=Q8NAP8-2; Sequence=VSP_039858; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q6AZW8
geneSymbol: ZNF660
reactome: R-HSA-212436;
name: Zinc finger protein 660
length: 331
go: ENSG00000144792;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9BYJ9
geneSymbol: YTHDF1
pdb: 4RCI;4RCJ;
length: 559
go: ENSG00000149658;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000303|PubMed:26046440}.
name:
YTH domain-containing family protein 1 (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1)

sequence:

opentargets:
cytoplasm [GO:0005737]; N6-methyladenosine-containing RNA binding [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BYJ9-1; Sequence=Displayed; Name=2; IsoId=Q9BYJ9-2; Sequence=VSP_006815, VSP_006816, VSP_006817; Note=No experimental confirmation available.; 


uniprotID: Q6ZQY7
name: Putative uncharacterized protein FLJ46792
length: 126
sequence:
MISFHVIFLSLGRGKLFLPVNFCFLKLKNSQVRIPKDFTCNLHVLFRTVQGEDRNTMFRGHWSIYSRNFPLAVVPAYVTEDGKNTSHRASGQFCNALSQGEIPSSLQLVNSYALEPRTDMPCNFLT


uniprotID: Q6ZT83
name: Uncharacterized protein FLJ44881
length: 130
snps: rs6565904
sequence:
MGALNSISLETNKSSFSMSWTPSVEHSSGTARTLRSCKLALVGFSSMSEFLFRASKTQPVTLFVPNVNSALCDQPVVRGVGIHEQRKRNISSLISVFNHWLPPLQLHLGRALICRFNSRGNFTCLMTAVK


uniprotID: Q6UXU0
name: Putative uncharacterized protein UNQ9165/PRO28630
length: 137
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MAALSRALGPLRTPAPPLWIGLFLVATGSQQSLAQPLPGNTTEATPRSLRASGSLCGPHAKAPYLCEATHEPAAARIRAQVPDTRWSRVGGQRFYSRVLSPLHRGPSGHTEASAQRSHMGKLKEPQPQDHKPGLGAS


uniprotID: Q8WZ26
name: Putative uncharacterized protein PP6455
length: 134
sequence:
MCEQLVCIFTYAYLKINLTKALGHHNPSYPVARAQPQTMFPSASECNAFPRVSKVPNRSGAAETALLVRVLPKPLKSQASLLSLPFIHITEQLSTHICVVLFKLFHVCLFTINNMNDCSMDAAERNAEGGLQLE


uniprotID: Q96K75
geneSymbol: ZNF514
reactome: R-HSA-212436;
name: Zinc finger protein 514
length: 400
go: ENSG00000144026;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: P0CH99
geneSymbol: ZNF705D
reactome: R-HSA-212436;
name: Zinc finger protein 705D
length: 300
go: ENSG00000215343;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: Q03924
geneSymbol: ZNF117
name: Zinc finger protein 117 (Provirus-linked krueppel) (h-PLK) (Zinc finger protein HPF9)
length: 483
go: ENSG00000152926;
snps: rs3807069 rs3807068
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8ND82
geneSymbol: ZNF280C
name: Zinc finger protein 280C (Suppressor of hairy wing homolog 3) (Zinc finger protein 633)
length: 737
go: ENSG00000056277;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8N402
name: Putative uncharacterized protein LOC388882
length: 240
snps: rs12169718 rs6519443 rs6519442
sequence:


uniprotID: Q8N3J9
geneSymbol: ZNF664
reactome: R-HSA-212436;
name: Zinc finger protein 664 (Zinc finger protein 176) (Zinc finger protein from organ of Corti)
length: 261
go: ENSG00000179195;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q15973
geneSymbol: ZNF124
reactome: R-HSA-212436;
name: Zinc finger protein 124 (Zinc finger protein HZF-16)
length: 351
go: ENSG00000196418;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q15973-3; Sequence=Displayed; Name=2; IsoId=Q15973-4; Sequence=VSP_015692; Name=3; Synonyms=HZF-16.2; IsoId=Q15973-1; Sequence=VSP_015691; Name=4; Synonyms=HZF-16.1; IsoId=Q15973-2; Sequence=VSP_015691, VSP_006895; Name=5; IsoId=Q15973-5; Sequence=VSP_046852; Note=No experimental confirmation available.; 


uniprotID: A8MUZ8
geneSymbol: ZNF705G
reactome: R-HSA-212436;
name: Putative zinc finger protein 705G
length: 300
go: ENSG00000215372;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q6ZRG5
name: Putative uncharacterized protein FLJ43944
length: 221
sequence:


uniprotID: Q6UXQ8
name: Putative uncharacterized protein UNQ6190/PRO20217
length: 127
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MAGVRARAPLPLALLLSLPAAPGGRDPSASRARFPQRLGRAPCFEVGLRKPPPPPLLSPPSFSSGSSRPLQRPRGPKDGAGRKVCAKLVKRLPGESGSCEDGQSAPAQPPRRRTGTRACPPRAPLWR


uniprotID: Q96N95
geneSymbol: ZNF396
name: Zinc finger protein 396 (Zinc finger and SCAN domain-containing protein 14)
length: 335
go: ENSG00000186496;
snps: rs9963473
location: SUBCELLULAR LOCATION: Isoform 1: Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Nucleus. Cytoplasm.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=ZNF396-fu; IsoId=Q96N95-1; Sequence=Displayed; Name=2; Synonyms=Truncated, ZNF396-nf; IsoId=Q96N95-2; Sequence=VSP_008768, VSP_006923; Name=3; IsoId=Q96N95-3; Sequence=VSP_020993; Note=No experimental confirmation available.; 


uniprotID: Q99592
geneSymbol: ZBTB18
length: 522
go: ENSG00000179456;
snps: rs1048824
location: SUBCELLULAR LOCATION: Nucleus. Note=Associates with condensed chromatin.
name:
Zinc finger and BTB domain-containing protein 18 (58 kDa repressor protein) (Transcriptional repressor RP58) (Translin-associated zinc finger protein 1) (TAZ-1) (Zinc finger protein 238) (Zinc finger protein C2H2-171)

sequence:

opentargets:
nuclear chromosome [GO:0000228]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle tissue development [GO:0007519]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99592-1; Sequence=Displayed; Name=2; IsoId=Q99592-2; Sequence=VSP_035381; 


uniprotID: Q9UPT8
geneSymbol: ZC3H4
pdb: 2CQE;
name: Zinc finger CCCH domain-containing protein 4
length: 1303
go: ENSG00000130749;
snps: rs192824 rs402833 rs309195
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding [GO:0001162]; negative regulation of transcription, DNA-templated [GO:0045892]


uniprotID: Q8N3U1
name: Putative uncharacterized protein LOC400692
length: 123
sequence:
MPDASLGSLGITWCFLESPLEVSSGRFGLARLLGSQDHGDDPAERGRTATDAWGPSRWGQSPGNGGGYCDASPPSALAPGDRAWALPASPSSGAPASQHCCLEKAGTRTKASPVWGRDGNTWN


uniprotID: A8K0R7
geneSymbol: ZNF839
reactome: R-HSA-212436;
name: Zinc finger protein 839 (Renal carcinoma antigen NY-REN-50)
length: 811
go: ENSG00000022976;
opentargets: metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]
snps: rs1543540 rs9464 rs28646161 rs1053019
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A8K0R7-1; Sequence=Displayed; Name=2; IsoId=A8K0R7-2; Sequence=VSP_032760; Note=No experimental confirmation available.; Name=3; IsoId=A8K0R7-5; Sequence=VSP_040648; Note=No experimental confirmation available.; 


uniprotID: P17019
geneSymbol: ZNF708
reactome: R-HSA-212436;
length: 499
snps: rs547516 rs1781873 rs1781872 rs504280
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 708 (Zinc finger protein 15) (Zinc finger protein 15-like 1) (Zinc finger protein KOX8)

sequence:


uniprotID: Q6ZRU5
name: Putative uncharacterized protein FLJ46089
length: 148
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MRCVTRTRNWWRRAARMPRAGSSAWWVAVCKQVCTRVGTYAVCWCSWNTGRFTGCPSWKDFWKPVGPALHVFNVKCEAQRGLKLTQPFTVACKIDPVLCKSGLGFPPQLFTGCVYLSTYTYPWQAQAECVRCPRDSNRCKRITPSACL


uniprotID: Q6ZTC4
name: Putative uncharacterized protein FLJ44790
length: 211
sequence:


uniprotID: Q5W150
name: Putative uncharacterized protein MGC163334
length: 140
sequence:
MDCKSPKRANICPHLPGGGLFSTPPSQAAWRTLLTALCFPGPTCTGPMREGPRAVYNPPRAHRNSSDNCVMKHLLCAGDKNGTRRHALPSPLEGSFQPGRQIPPPQTPSTDPQTLPLSFRSLLRCHQLCAASLPPSLKLP


uniprotID: Q86YH2
geneSymbol: ZNF280B
length: 543
snps: rs2236729 rs12484816
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 280B (5'OY11.1) (Suppressor of hairy wing homolog 2) (Zinc finger protein 279) (Zinc finger protein 632)

sequence:


uniprotID: Q8N9L7
name: Putative uncharacterized protein FLJ36925
length: 120
sequence:
MTMTMSYKAIEKIPRCSWNREEPGEQWNKIYSVETGLLGTYSFEWQSQVANKTMRKRNTNSICGRQHEPHCPVSITRAIAQPQLLTFPDSLASRGGHMTQSGQCHVSGSLLGRGHKSRGR


uniprotID: Q96EG3
geneSymbol: ZNF837
name: Zinc finger protein 837
length: 531
go: ENSG00000152475;
snps: rs7256940 rs7255596
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9H7R5
geneSymbol: ZNF665
reactome: R-HSA-212436;
name: Zinc finger protein 665 (Zinc finger protein 160-like)
length: 613
go: ENSG00000197497;
snps: rs12460170 rs4801959 rs4801958
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H7R5-1; Sequence=Displayed; Name=2; IsoId=Q9H7R5-2; Sequence=VSP_040751; 


uniprotID: P0C880
name: Putative uncharacterized protein FLJ40606
length: 135
sequence:
MAAATETGQAAVPSRKRRRGRRPPASDPQTLARLAAGPWLPGTLTCPERTGGDAATRSARPPVLPPPPRPPQRRCRHLVSRAGTPRCACAGTASEGPRRGRAAILSVAGSAGSSHPACFRPPPLLPIRPCCSLWR


uniprotID: Q9H5U6
geneSymbol: ZCCHC4
name: Zinc finger CCHC domain-containing protein 4
length: 513
go: ENSG00000168228;
snps: rs3752873 rs315675
sequence:

opentargets:
methyltransferase activity [GO:0008168]; nucleic acid binding [GO:0003676]; transferase activity, transferring acyl groups [GO:0016746]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H5U6-1; Sequence=Displayed; Name=2; IsoId=Q9H5U6-2; Sequence=VSP_043359; Note=No experimental confirmation available.; Name=3; IsoId=Q9H5U6-3; Sequence=VSP_043360; Note=No experimental confirmation available.; 


uniprotID: P52736
geneSymbol: ZNF133
reactome: R-HSA-212436;
name: Zinc finger protein 133 (Zinc finger protein 150)
length: 654
go: ENSG00000125846;
snps: rs1033545 rs2228273
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P52736-1; Sequence=Displayed; Name=2; IsoId=P52736-2; Sequence=VSP_039148; Name=3; IsoId=P52736-3; Sequence=VSP_055021; Note=No experimental confirmation available.; Name=4; IsoId=P52736-4; Sequence=VSP_055022; Note=No experimental confirmation available.; Name=5; IsoId=P52736-5; Sequence=VSP_055023; Note=No experimental confirmation available.; 


uniprotID: P52741
geneSymbol: ZNF134
name: Zinc finger protein 134
length: 427
go: ENSG00000213762;
snps: rs10414451 rs10413455 rs34034473
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P52741-1; Sequence=Displayed; Name=2; IsoId=P52741-2; Sequence=VSP_035666; 


uniprotID: Q6ZSR3
name: Putative uncharacterized protein FLJ45275, mitochondrial
length: 168
opentargets: mitochondrion [GO:0005739]
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
sequence:
MGWRFPSPSPRQASPVAPLLAAPTAVRSCSHCSGQREAISSHPLQLETPELGVCLPWHWEGWRQVRKITPSLPQPPGSQVPLEVTFHVRATLPHFRGGETKARRAREEGKLPSLGNAPAPRRRSVAWPAAEGSCAAPESSPPASEASLPAPESSLLVAGSGDLCADSF


uniprotID: P62699
geneSymbol: YPEL5
reactome: R-HSA-6798695;
name: Protein yippee-like 5
length: 121
go: ENSG00000119801;
sequence:
MGRIFLDHIGGTRLFSCANCDTILTNRSELISTRFTGATGRAFLFNKVVNLQYSEVQDRVMLTGRHMVRDVSCKNCNSKLGWIYEFATEDSQRYKEGRVILERALVRESEGFEEHVPSDNS

opentargets:
extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; mitotic spindle pole [GO:0097431]; nucleus [GO:0005634]; tertiary granule lumen [GO:1904724]; ubiquitin ligase complex [GO:0000151]; metal ion binding [GO:0046872]; cell proliferation [GO:0008283]; neutrophil degranulation [GO:0043312]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q65Z55}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q65Z55}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q65Z55}. Midbody {ECO:0000250|UniProtKB:Q65Z55}. Note=Deteted in nucleus and at the centrosome during interphase. During mitosis, detected on the mitotic spindle, at spindle poles and at the midbody. {ECO:0000250|UniProtKB:Q65Z55}.


uniprotID: Q13105
geneSymbol: ZBTB17
reactome: R-HSA-381038;
pdb: 2LVR;2LVT;2LVU;2M0D;2M0E;2M0F;2N25;2N26;2Q81;3M52;4U2M;4U2N;5ION;
length: 803
go: ENSG00000116809;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14739298, ECO:0000269|PubMed:9312026}.
name:
Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60)

sequence:

opentargets:
nucleoplasm [GO:0005654]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; core promoter binding [GO:0001047]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription coactivator binding [GO:0001223]; transcription factor binding [GO:0008134]; ectoderm development [GO:0007398]; gastrulation with mouth forming second [GO:0001702]; IRE1-mediated unfolded protein response [GO:0036498]; negative regulation of cell cycle [GO:0045786]; negative regulation of cell proliferation [GO:0008285]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13105-1; Sequence=Displayed; Name=2; IsoId=Q13105-2; Sequence=VSP_013424; Note=No experimental confirmation available.; Name=3; IsoId=Q13105-3; Sequence=VSP_044564; Note=No experimental confirmation available.; 


uniprotID: Q5H9K5
geneSymbol: ZMAT1
name: Zinc finger matrin-type protein 1
length: 638
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]
snps: rs17282855 rs5944882
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5H9K5-1; Sequence=Displayed; Name=2; IsoId=Q5H9K5-2; Sequence=VSP_029533; 


uniprotID: Q9HA38
geneSymbol: ZMAT3
name: Zinc finger matrin-type protein 3 (Zinc finger protein WIG-1) (p53-activated gene 608 protein)
length: 289
go: ENSG00000172667;
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cellular response to DNA damage stimulus [GO:0006974]; positive regulation of apoptotic process [GO:0043065]; protein transport [GO:0015031]; regulation of growth [GO:0040008]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HA38-1; Sequence=Displayed; Name=2; IsoId=Q9HA38-2; Sequence=VSP_040093; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11571644}. Nucleus, nucleolus {ECO:0000269|PubMed:11571644}.


uniprotID: O14709
geneSymbol: ZNF197
reactome: R-HSA-212436;
length: 1029
go: ENSG00000186448;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 197 (Zinc finger protein with KRAB and SCAN domains 9) (ZnF20) (pVHL-associated KRAB domain-containing protein)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14709-1; Sequence=Displayed; Name=2; Synonyms=VHLaK; IsoId=O14709-2; Sequence=VSP_043021, VSP_043022; Note=Negative regulator of HIF1A transactivation.; 


uniprotID: Q9H9D4
geneSymbol: ZNF408
name: Zinc finger protein 408 (PR domain zinc finger protein 17)
length: 720
go: ENSG00000175213;
snps: rs536561101 rs36017347 rs373273223 rs561740128 rs781192528
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23716654, ECO:0000269|PubMed:25882705}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]


uniprotID: Q9HCL3
geneSymbol: ZFP14
reactome: R-HSA-212436;
name: Zinc finger protein 14 homolog (Zfp-14) (Zinc finger protein 531)
length: 533
go: ENSG00000142065;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; blastocyst hatching [GO:0001835]


uniprotID: P59817
geneSymbol: ZNF280A
name: Zinc finger protein 280A (3'OY11.1) (Suppressor of hairy wing homolog 1) (Zinc finger protein 636)
length: 542
snps: rs361959 rs362011 rs361580 rs362132 rs362124 rs16989015 rs362003 rs361762 rs361666
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O75820
geneSymbol: ZNF189
reactome: R-HSA-212436;
name: Zinc finger protein 189
length: 626
go: ENSG00000136870;
snps: rs10989492
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; negative regulation of transcription by RNA polymerase II [GO:0000122]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O75820-1; Sequence=Displayed; Name=2; IsoId=O75820-2; Sequence=VSP_006900; Name=3; Synonyms=B2; IsoId=O75820-3; Sequence=VSP_006901; Name=4; IsoId=O75820-4; Sequence=VSP_006899; 


uniprotID: Q7Z7K2
geneSymbol: ZNF467
reactome: R-HSA-381340;
name: Zinc finger protein 467
length: 595
go: ENSG00000181444;
snps: rs6965332
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: Q8N184
geneSymbol: ZNF567
reactome: R-HSA-212436;
name: Zinc finger protein 567
length: 647
go: ENSG00000189042;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=Q8N184-3; Sequence=Displayed; Note=No experimental confirmation available.; Name=1; IsoId=Q8N184-1; Sequence=VSP_016383; Name=2; IsoId=Q8N184-2; Sequence=VSP_016384; Note=No experimental confirmation available.; 


uniprotID: Q8TD17
geneSymbol: ZNF398
reactome: R-HSA-212436;
name: Zinc finger protein 398 (Zinc finger DNA-binding protein p52/p71)
length: 642
go: ENSG00000197024;
snps: rs3801979 rs2240370
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=p71; IsoId=Q8TD17-1; Sequence=Displayed; Name=2; Synonyms=p52; IsoId=Q8TD17-2; Sequence=VSP_006926; 


uniprotID: Q8N9P0
name: Putative uncharacterized protein FLJ36797
length: 234
sequence:


uniprotID: Q499Y3
name: Putative uncharacterized protein C10orf88-like
length: 187
sequence:
MRAVSANYSTGSPAVKSRIELDRIQTIMESMGSKLSPGAQQLINMVRFQQWNCIPIEEQLQLVLGNAGYKQMTGLQCSSALGALDKLSSTPFPFRTGLTSGNVTENLQAYIDKSTQASSGENSTKLDECKIVPQNHSLLENDLKNATSPFLPKKANDNSNIPNSELLPFLQNLCSQVNYLLVGRKAE


uniprotID: P0C879
name: Putative uncharacterized protein FLJ43185
length: 139
sequence:
MYNPWQVGASLAPARAGPRPFPTPRARPPDCSGGHAPSGFPALGLRTAQRPRPFSSSPRSASGRLRGPRPVARGPAHSSSPTGLPAYLPPAAALDSQTSAPTVSPVTRPRVVARGKTPRVSLAGLETLSSLLHQQQLFD


uniprotID: Q6ZQT0
name: Putative uncharacterized protein FLJ45035
length: 140
sequence:
MFARLCPVSETFGRLCPVSETFARLCPVSETFARLCPVSETFARLCPVSETFGRLCPVSEMFGRLSPVSETFGRLCPVSETFGRLCPVSEMFARLCPVSETFGRLSPVSEMFGRLCPVSEMFGRLCPVSEMFGRLCPVIT


uniprotID: Q9ULM3
geneSymbol: YEATS2
reactome: R-HSA-3214847;
pdb: 5IQL;5XNV;
name: YEATS domain-containing protein 2
length: 1422
go: ENSG00000163872;
snps: rs16858033 rs262993 rs3211095
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:18838386, ECO:0000305|PubMed:19103755}.
sequence:

opentargets:
Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; mitotic spindle [GO:0072686]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; histone binding [GO:0042393]; modification-dependent protein binding [GO:0140030]; TBP-class protein binding [GO:0017025]; histone H3 acetylation [GO:0043966]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]


uniprotID: Q6ZRM9
name: Putative uncharacterized protein FLJ46235
length: 215
snps: rs12667117 rs12671601 rs10274643
sequence:


uniprotID: Q75L30
name: Putative uncharacterized protein FLJ92257
length: 129
sequence:
MATFPGQVSTYFLAAWTGPGPATHWPLYAQLMPHSGLSRPSSCPGTSSPGPKLPQVGLSRPSCCLPAFSPGLALPPGCIYKTNSCLTTTFYGSAPAQLLPAFVGPKLPQVKLFRPTFCLAVACTDPALA


uniprotID: Q8N1Y9
name: Putative uncharacterized protein FLJ37218
length: 231
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q8N8F6
geneSymbol: YIPF7
length: 280
snps: rs2348353
name:
Protein YIPF7 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 9) (YIP1 family member 7)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8N8F6-1; Sequence=Displayed; Name=2; IsoId=Q8N8F6-2; Sequence=VSP_033435; Note=No experimental confirmation available.; Name=3; IsoId=Q8N8F6-3; Sequence=VSP_033431, VSP_033432; Note=No experimental confirmation available.; Name=4; IsoId=Q8N8F6-4; Sequence=VSP_033433, VSP_033434; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JIM5}; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994}. Note=Evenly distributed between cis- and trans-Golgi apparatus. {ECO:0000269|PubMed:27999994}.


uniprotID: Q8N9G6
name: Putative UPF0607 protein FLJ37424
length: 341
sequence:


uniprotID: Q9BWQ6
geneSymbol: YIPF2
name: Protein YIPF2 (YIP1 family member 2)
length: 316
go: ENSG00000130733;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; integral component of membrane [GO:0016021]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; Rab GTPase binding [GO:0017137]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994}. Late endosome membrane {ECO:0000269|PubMed:27999994}. Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.


uniprotID: Q9BSR8
geneSymbol: YIPF4
name: Protein YIPF4 (YIP1 family member 4)
length: 244
go: ENSG00000119820;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:21757827, ECO:0000269|PubMed:26235900, ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000269|PubMed:21757827}.


uniprotID: Q969M3
geneSymbol: YIPF5
length: 257
go: ENSG00000145817;
name:
Protein YIPF5 (Five-pass transmembrane protein localizing in the Golgi apparatus and the endoplasmic reticulum 5) (Smooth muscle cell-associated protein 5) (SMAP-5) (YIP1 family member 5) (YPT-interacting protein 1 A)

sequence:

opentargets:
COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum exit site [GO:0070971]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; protein transport [GO:0015031]; regulation of ER to Golgi vesicle-mediated transport [GO:0060628]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q969M3-1; Sequence=Displayed; Name=2; Synonyms=D; IsoId=Q969M3-2; Sequence=VSP_018253; Name=3; Synonyms=I; IsoId=Q969M3-3; Sequence=VSP_018254; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9EQQ2}; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000250|UniProtKB:Q5XID0}. Note=Enriched at the endoplasmic reticulum exit sites. Colocalizes with RAB1A. Incorporated into COPII-coated vesicles.


uniprotID: Q9H354
name: Putative uncharacterized protein PRO1933
length: 126
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
MNKHNLRLVQLASELILIEIIPKLFLSQVTTISHIKREKIPPNHRKGILCMFPWQCVVYVFSNFVWLVIHRFSNGFIQFLGEPYRLMTASGTHGRIKFMVDIPIIKNTQVLRIPVLKDPKMLSKKH


uniprotID: O43670
geneSymbol: ZNF207
name: BUB3-interacting and GLEBS motif-containing protein ZNF207 (BuGZ) (hBuGZ) (Zinc finger protein 207)
length: 478
go: ENSG00000010244;
snps: rs3795244
sequence:

opentargets:
condensed chromosome kinetochore [GO:0000777]; cytoplasm [GO:0005737]; kinetochore [GO:0000776]; microtubule [GO:0005874]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle matrix [GO:1990047]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; heparin binding [GO:0008201]; microtubule binding [GO:0008017]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; attachment of spindle microtubules to kinetochore [GO:0008608]; cell division [GO:0051301]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly [GO:0090307]; mitotic spindle assembly checkpoint [GO:0007094]; protein stabilization [GO:0050821]; regulation of chromosome segregation [GO:0051983]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=O43670-1; Sequence=Displayed; Name=2; IsoId=O43670-2; Sequence=VSP_006904, VSP_006905; Name=3; IsoId=O43670-3; Sequence=VSP_006903, VSP_006904; Name=4; IsoId=O43670-4; Sequence=VSP_006904; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26388440}. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}.


uniprotID: Q9P217
geneSymbol: ZSWIM5
name: Zinc finger SWIM domain-containing protein 5
length: 1185
go: ENSG00000162415;
snps: rs12733746
sequence:

opentargets:
Cul2-RING ubiquitin ligase complex [GO:0031462]; extracellular space [GO:0005615]; zinc ion binding [GO:0008270]; regulation of axon guidance [GO:1902667]


uniprotID: P0C6A0
geneSymbol: ZGLP1
name: GATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1)
length: 271
go: ENSG00000220201;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; multicellular organism development [GO:0007275]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oocyte development [GO:0048599]; spermatogenesis [GO:0007283]


uniprotID: Q8TF20
geneSymbol: ZNF721
reactome: R-HSA-212436;
name: Zinc finger protein 721
length: 911
go: ENSG00000182903;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TF20-1; Sequence=Displayed; Name=2; IsoId=Q8TF20-2; Sequence=VSP_040879; 


uniprotID: O75362
geneSymbol: ZNF217
reactome: R-HSA-9018519;
pdb: 2HU2;3UK3;4F2J;4IS1;
name: Zinc finger protein 217
length: 1048
go: ENSG00000171940;
snps: rs767530299 rs6063966 rs34323943
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
histone deacetylase complex [GO:0000118]; mitochondrion [GO:0005739]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription regulatory region DNA binding [GO:0044212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]


uniprotID: Q969S3
geneSymbol: ZNF622
name: Zinc finger protein 622 (Zinc finger-like protein 9)
length: 477
go: ENSG00000173545;
sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; intrinsic apoptotic signaling pathway in response to oxidative stress [GO:0008631]; positive regulation of apoptotic process [GO:0043065]; positive regulation of JNK cascade [GO:0046330]; positive regulation of kinase activity [GO:0033674]; positive regulation of MAPK cascade [GO:0043410]; ribosomal large subunit biogenesis [GO:0042273]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11802789}. Nucleus {ECO:0000269|PubMed:11802789}.


uniprotID: Q96H40
geneSymbol: ZNF486
reactome: R-HSA-212436;
name: Zinc finger protein 486 (KRAB domain only protein 2)
length: 463
go: ENSG00000256229;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: Q9NR11
geneSymbol: ZNF302
reactome: R-HSA-212436;
length: 478
go: ENSG00000089335;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 302 (Zinc finger protein 135-like) (Zinc finger protein 140-like) (Zinc finger protein 327)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NR11-1; Sequence=Displayed; Name=2; IsoId=Q9NR11-2; Sequence=VSP_006914; 


uniprotID: Q96MN9
geneSymbol: ZNF488
name: Zinc finger protein 488
length: 340
go: ENSG00000265763;
snps: rs35618062 rs12251609 rs3814160
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5HZG9}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; oligodendrocyte development [GO:0014003]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96MN9-1; Sequence=Displayed; Name=2; IsoId=Q96MN9-2; Sequence=VSP_055961; Note=No experimental confirmation available.; 


uniprotID: Q68DY1
geneSymbol: ZNF626
reactome: R-HSA-212436;
name: Zinc finger protein 626
length: 528
go: ENSG00000188171;
snps: rs8106117 rs3209058 rs8111015 rs8110802 rs4809072 rs10408597
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q68DY1-1; Sequence=Displayed; Name=2; IsoId=Q68DY1-2; Sequence=VSP_022263; Note=No experimental confirmation available.; Name=3; IsoId=Q68DY1-3; Sequence=VSP_043270, VSP_043271; Note=No experimental confirmation available.; 


uniprotID: Q6ZR52
geneSymbol: ZNF493
reactome: R-HSA-212436;
name: Zinc finger protein 493
length: 646
go: ENSG00000196268;
snps: rs4621113 rs10414834
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZR52-1; Sequence=Displayed; Name=2; IsoId=Q6ZR52-2; Sequence=VSP_038298; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZR52-3; Sequence=VSP_046656, VSP_046657; 


uniprotID: Q9Y473
geneSymbol: ZNF175
reactome: R-HSA-212436;
name: Zinc finger protein 175 (Zinc finger protein OTK18)
length: 711
go: ENSG00000105497;
snps: rs60097262 rs3764548
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
sequence:

opentargets:
cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; defense response to virus [GO:0051607]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]


uniprotID: Q8N587
geneSymbol: ZNF561
reactome: R-HSA-212436;
name: Zinc finger protein 561
length: 486
go: ENSG00000171469;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N587-1; Sequence=Displayed; Name=2; IsoId=Q8N587-2; Sequence=VSP_055964; Note=No experimental confirmation available.; 


uniprotID: P51504
geneSymbol: ZNF80
name: Zinc finger protein 80 (ZNFpT17)
length: 273
go: ENSG00000174255;
snps: rs6438191 rs3732782
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8N6M9
geneSymbol: ZFAND2A
name: AN1-type zinc finger protein 2A
length: 145
go: ENSG00000178381;
snps: rs17855544
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:
MEFPDLGKHCSEKTCKQLDFLPVKCDACKQDFCKDHFPYAAHKCPFAFQKDVHVPVCPLCNTPIPVKKGQIPDVVVGDHIDRDCDSHPGKKKEKIFTYRCSKEGCKKKEMLQMVCAQCHGNFCIQHRHPLDHSCRHGSRPTIKAG

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; proteasome complex [GO:0000502]; zinc ion binding [GO:0008270]; cellular response to arsenic-containing substance [GO:0071243]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]


uniprotID: Q9BRH9
geneSymbol: ZNF251
name: Zinc finger protein 251
length: 671
go: ENSG00000198169;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8IYH5
geneSymbol: ZZZ3
reactome: R-HSA-3214847;
pdb: 2FC7;2YUM;6E83;6E86;
name: ZZ-type zinc finger-containing protein 3
length: 903
go: ENSG00000036549;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
sequence:

opentargets:
Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8IYH5-1; Sequence=Displayed; Name=2; IsoId=Q8IYH5-2; Sequence=VSP_025511; Name=3; IsoId=Q8IYH5-3; Sequence=VSP_025509, VSP_025510; Note=No experimental confirmation available.; Name=4; IsoId=Q8IYH5-4; Sequence=VSP_025512, VSP_025513; Note=No experimental confirmation available.; 


uniprotID: O14978
geneSymbol: ZNF263
reactome: R-HSA-212436;
length: 683
go: ENSG00000006194;
snps: rs220379 rs34236132 rs57710602
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
name:
Zinc finger protein 263 (Zinc finger protein FPM315) (Zinc finger protein with KRAB and SCAN domains 12)

sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: Q08AG5
geneSymbol: ZNF844
name: Zinc finger protein 844
length: 666
go: ENSG00000223547;
snps: rs12611158 rs10422576 rs7259684 rs7259845 rs6511763 rs8102258 rs1438694 rs10426017 rs55703333
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: Q6NXT4
geneSymbol: SLC30A6
reactome: R-HSA-264876;R-HSA-435368;
name: Zinc transporter 6 (ZnT-6) (Solute carrier family 30 member 6)
length: 461
go: ENSG00000152683;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; zinc ion transmembrane transporter activity [GO:0005385]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6NXT4-1; Sequence=Displayed; Name=2; IsoId=Q6NXT4-2; Sequence=VSP_029861; Note=No experimental confirmation available.; Name=4; IsoId=Q6NXT4-4; Sequence=VSP_045198; Note=No experimental confirmation available.; Name=3; IsoId=Q6NXT4-3; Sequence=VSP_029862; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.


uniprotID: P52746
geneSymbol: ZNF142
name: Zinc finger protein 142 (HA4654)
length: 1687
go: ENSG00000115568;
snps: rs3770214 rs3770213 rs3821033
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8TF39
geneSymbol: ZNF483
reactome: R-HSA-212436;
pdb: 2CTU;
name: Zinc finger protein 483 (Zinc finger protein with KRAB and SCAN domains 16)
length: 744
go: ENSG00000173258;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TF39-1; Sequence=Displayed; Name=2; IsoId=Q8TF39-2; Sequence=VSP_043023, VSP_043024; Note=No experimental confirmation available.; 


uniprotID: Q569K4
geneSymbol: ZNF385B
name: Zinc finger protein 385B (Zinc finger protein 533)
length: 471
go: ENSG00000144331;
snps: rs2271761
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22945289}.
sequence:

opentargets:
fibrillar center [GO:0001650]; nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; p53 binding [GO:0002039]; zinc ion binding [GO:0008270]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=IF-1; IsoId=Q569K4-1; Sequence=Displayed; Name=2; Synonyms=IF-2; IsoId=Q569K4-2; Sequence=VSP_015974, VSP_015976; Note=Major isoform in tonsil.; Name=3; Synonyms=IF-3; IsoId=Q569K4-3; Sequence=VSP_015973; Note=Major isoform in lymph node.; Name=4; IsoId=Q569K4-4; Sequence=VSP_015972, VSP_015977, VSP_015978; Note=No experimental confirmation available.; Name=5; IsoId=Q569K4-5; Sequence=VSP_015975, VSP_015979, VSP_015980; Note=No experimental confirmation available.; 


uniprotID: Q5TC79
geneSymbol: ZBTB37
name: Zinc finger and BTB domain-containing protein 37
length: 503
go: ENSG00000185278;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5TC79-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q5TC79-2; Sequence=VSP_014441, VSP_014442; Note=No experimental confirmation available.; Name=3; IsoId=Q5TC79-3; Sequence=VSP_014440; Note=No experimental confirmation available.; 


uniprotID: Q9NZL3
geneSymbol: ZNF224
reactome: R-HSA-212436;
pdb: 2ELY;2ELZ;2EM0;2EM6;2EM7;2EM8;2EM9;2EN1;2EN8;2ENA;2ENC;2EOQ;2EOR;2EQ4;2YSP;2YTH;
length: 707
go: ENSG00000267680;
snps: rs2068061 rs4239529 rs3208201 rs58935748 rs3746323 rs3746319
name:
Zinc finger protein 224 (Bone marrow zinc finger 2) (BMZF-2) (Zinc finger protein 233) (Zinc finger protein 255) (Zinc finger protein 27) (Zinc finger protein KOX22)

sequence:

opentargets:
nuclear membrane [GO:0031965]; nucleus [GO:0005634]; transcriptional repressor complex [GO:0017053]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12239212, ECO:0000269|PubMed:20587513, ECO:0000269|PubMed:23665872}. Note=Colocalizes with DEPDC1A at the nucleus.


uniprotID: Q70YC5
geneSymbol: ZNF365
name: Protein ZNF365 (DISC1-binding zinc-finger protein) (Protein su48)
length: 407
go: ENSG00000138311;
snps: rs3758490
sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; cerebellar molecular layer morphogenesis [GO:0021687]; dendrite arborization [GO:0140059]; dendritic spine morphogenesis [GO:0060997]; negative regulation of neuron projection development [GO:0010977]; positive regulation of oligodendrocyte differentiation [GO:0048714]; regulation of DNA strand resection involved in replication fork processing [GO:0110026]; regulation of double-strand break repair via homologous recombination [GO:0010569]; telomere maintenance [GO:0000723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=ZNF365A; IsoId=Q70YC5-1; Sequence=Displayed; Name=2; Synonyms=ZNF365B; IsoId=Q70YC5-2; Sequence=VSP_016599, VSP_016600; Name=3; Synonyms=ZNF365C; IsoId=Q70YC5-3; Sequence=VSP_016598; Name=5; IsoId=Q70YC5-4; Sequence=VSP_016597; Note=No experimental confirmation available.; Name=6; IsoId=Q70YC5-5; Sequence=VSP_016596; Note=No experimental confirmation available.; Name=4; Synonyms=Talanin, ZNF365D; IsoId=Q70YC4-1; Sequence=External; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16617106}. Note=localizes to the centrosome at all stages of the cell cycle. {ECO:0000269|PubMed:16617106}.


uniprotID: Q14202
geneSymbol: ZMYM3
name: Zinc finger MYM-type protein 3 (Zinc finger protein 261)
length: 1370
go: ENSG00000147130;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]; cytoskeleton organization [GO:0007010]; multicellular organism development [GO:0007275]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q14202-1; Sequence=Displayed; Name=2; IsoId=Q14202-2; Sequence=VSP_004492; Note=No experimental confirmation available. {ECO:0000244|PubMed:28112733}; Name=3; IsoId=Q14202-3; Sequence=VSP_043262, VSP_043263; 


uniprotID: Q96F45
geneSymbol: ZNF503
name: Zinc finger protein 503
length: 646
go: ENSG00000165655;
snps: rs35764982
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; G1 to G0 transition involved in cell differentiation [GO:0070315]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; neural precursor cell proliferation [GO:0061351]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96F45-1; Sequence=Displayed; Name=2; IsoId=Q96F45-2; Sequence=VSP_026395; Note=No experimental confirmation available.; Name=3; IsoId=Q96F45-3; Sequence=VSP_026394; Note=No experimental confirmation available.; 


uniprotID: Q6ZT77
geneSymbol: ZNF826P
name: Putative zinc finger protein 826
length: 177
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]
snps: rs7247776
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:
MRRFILERNPTNVKNMAKLSPIPHTLLGIRKFMLERNHTSVINVAQPLFYPQPLVNMRRFILERNSTNVKNVAKPSTIFHTLLYIRQFILERNAINGIKTFTWSSSPHKHRRTHTGEKPYKCEECGKAFTASSTLSEYKTIHTGEKPCKCEECGKAFNWSSDFNKHKRIHSGQKPIL


uniprotID: Q17R98
geneSymbol: ZNF827
name: Zinc finger protein 827
length: 1081
go: ENSG00000151612;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; regulation of gene expression [GO:0010468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q17R98-1; Sequence=Displayed; Name=2; IsoId=Q17R98-2; Sequence=VSP_032464, VSP_032465; Note=No experimental confirmation available.; Name=3; IsoId=Q17R98-3; Sequence=VSP_032463; Note=No experimental confirmation available.; 


uniprotID: Q53GI3
geneSymbol: ZNF394
reactome: R-HSA-212436;
name: Zinc finger protein 394 (Zinc finger protein with KRAB and SCAN domains 14)
length: 561
go: ENSG00000160908;
snps: rs3735454
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q53GI3-1; Sequence=Displayed; Name=2; IsoId=Q53GI3-3; Sequence=VSP_056547, VSP_056548; Note=No experimental confirmation available.; 


uniprotID: Q5TEC3
geneSymbol: ZNF697
reactome: R-HSA-212436;
name: Zinc finger protein 697
length: 545
go: ENSG00000143067;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O60293
geneSymbol: ZFC3H1
length: 1989
go: ENSG00000133858;
snps: rs1011332 rs11541286
name:
Zinc finger C3H1 domain-containing protein (Coiled-coil domain-containing protein 131) (Proline/serine-rich coiled-coil protein 2)

sequence:

opentargets:
exosome (RNase complex) [GO:0000178]; extracellular space [GO:0005615]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; RNA processing [GO:0006396]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O60293-1; Sequence=Displayed; Name=2; IsoId=O60293-2; Sequence=VSP_024995; Note=No experimental confirmation available.; Name=4; IsoId=O60293-4; Sequence=VSP_024992, VSP_024993; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27871484}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:27871484}.


uniprotID: Q96CK0
geneSymbol: ZNF653
name: Zinc finger protein 653 (67 kDa zinc finger protein) (Zinc finger protein Zip67)
length: 615
go: ENSG00000161914;
snps: rs17851437 rs35556595
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; nucleus [GO:0005634]; AF-2 domain binding [GO:0050682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; receptor antagonist activity [GO:0048019]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; extracellular negative regulation of signal transduction [GO:1900116]; negative regulation of nucleic acid-templated transcription [GO:1903507]


uniprotID: O60481
geneSymbol: ZIC3
reactome: R-HSA-2892247;R-HSA-452723;
pdb: 2EJ4;2RPC;
name: Zinc finger protein ZIC 3 (Zinc finger protein 203) (Zinc finger protein of the cerebellum 3)
length: 467
go: ENSG00000156925;
snps: rs147232392 rs373628598 rs104894963 rs104894961 rs122463168 rs122462165 rs104894962
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; anterior/posterior pattern specification [GO:0009952]; cell differentiation [GO:0030154]; determination of digestive tract left/right asymmetry [GO:0071907]; determination of left/right asymmetry in nervous system [GO:0035545]; determination of left/right symmetry [GO:0007368]; determination of liver left/right asymmetry [GO:0071910]; determination of pancreatic left/right asymmetry [GO:0035469]; heart looping [GO:0001947]; lung development [GO:0030324]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; somatic stem cell population maintenance [GO:0035019]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=ZIC3-A; IsoId=O60481-1; Sequence=Displayed; Name=2; Synonyms=ZIC3-B; IsoId=O60481-2; Sequence=VSP_044010; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Note=Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. {ECO:0000250}.


uniprotID: Q86YE8
geneSymbol: ZNF573
reactome: R-HSA-212436;
name: Zinc finger protein 573
length: 665
go: ENSG00000189144;
snps: rs3752365 rs3752365
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86YE8-1; Sequence=Displayed; Name=2; IsoId=Q86YE8-2; Sequence=VSP_022895; Note=No experimental confirmation available.; Name=3; IsoId=Q86YE8-3; Sequence=VSP_022894; Note=No experimental confirmation available.; Name=4; IsoId=Q86YE8-4; Sequence=VSP_022896, VSP_022897; Note=No experimental confirmation available.; 


uniprotID: Q9BUG6
geneSymbol: ZSCAN5A
name: Zinc finger and SCAN domain-containing protein 5A (Zinc finger protein 495)
length: 496
go: ENSG00000131848;
snps: rs145011101 rs34187696
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BUG6-1; Sequence=Displayed; Name=2; IsoId=Q9BUG6-2; Sequence=VSP_055989, VSP_055990; Note=No experimental confirmation available.; 


uniprotID: Q9NUE0
geneSymbol: ZDHHC18
length: 388
go: ENSG00000204160;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 18) (DHHC-18)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NUE0-1; Sequence=Displayed; Name=2; IsoId=Q9NUE0-2; Sequence=VSP_056000; Note=No experimental confirmation available.; 


uniprotID: Q96NJ6
geneSymbol: ZFP3
name: Zinc finger protein 3 homolog (Zfp-3) (Zinc finger protein 752)
length: 502
go: ENSG00000180787;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q6ZNG0
geneSymbol: ZNF620
reactome: R-HSA-212436;
name: Zinc finger protein 620
length: 422
go: ENSG00000177842;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZNG0-1; Sequence=Displayed; Name=2; IsoId=Q6ZNG0-2; Sequence=VSP_016040; Note=No experimental confirmation available.; 


uniprotID: Q96MM3
geneSymbol: ZFP42
length: 310
go: ENSG00000179059;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
Zinc finger protein 42 homolog (Zfp-42) (Reduced expression protein 1) (REX-1) (hREX-1) (Zinc finger protein 754)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear chromatin [GO:0000790]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; transcription factor complex [GO:0005667]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II repressing transcription factor binding [GO:0001103]; sequence-specific DNA binding [GO:0043565]; female gonad development [GO:0008585]; male gonad development [GO:0008584]; meiotic cell cycle [GO:0051321]


uniprotID: A0A1B0GTU1
geneSymbol: ZC3H11B
name: Zinc finger CCCH domain-containing protein 11B
length: 805
go: ENSG00000215817;
opentargets: metal ion binding [GO:0046872]
sequence:


uniprotID: Q5T0B9
geneSymbol: ZNF362
name: Zinc finger protein 362
length: 420
go: ENSG00000160094;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: P17017
geneSymbol: ZNF14
reactome: R-HSA-212436;
length: 642
go: ENSG00000105708;
snps: rs12973901 rs3752153
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 14 (Gonadotropin-inducible ovary transcription repressor 4) (GIOT-4) (Zinc finger protein KOX6)

sequence:


uniprotID: Q96GE5
geneSymbol: ZNF799
reactome: R-HSA-212436;
name: Zinc finger protein 799 (Zinc finger protein 842)
length: 643
go: ENSG00000196466;
snps: rs1134387 rs8112445
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96GE5-1; Sequence=Displayed; Name=2; IsoId=Q96GE5-2; Sequence=VSP_039164; 


uniprotID: Q8IWR0
geneSymbol: ZC3H7A
pdb: 2D9M;
name: Zinc finger CCCH domain-containing protein 7A
length: 971
go: ENSG00000122299;
snps: rs1429077 rs16958654
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]; posttranscriptional regulation of gene expression [GO:0010608]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWR0-1; Sequence=Displayed; Name=2; IsoId=Q8IWR0-2; Sequence=VSP_014383; 


uniprotID: Q9Y330
geneSymbol: ZBTB12
name: Zinc finger and BTB domain-containing protein 12 (Protein G10)
length: 459
go: ENSG00000204366;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: P36508
geneSymbol: ZNF76
name: Zinc finger protein 76 (Zinc finger protein 523)
length: 570
go: ENSG00000065029;
snps: rs2228265 rs33959228 rs35582935
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=P36508-1; Sequence=Displayed; Name=1; IsoId=P36508-2; Sequence=VSP_006894; Note=No experimental confirmation available.; 


uniprotID: Q15697
geneSymbol: ZNF174
pdb: 1Y7Q;
name: Zinc finger protein 174 (AW-1) (Zinc finger and SCAN domain-containing protein 8)
length: 407
go: ENSG00000103343;
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region DNA binding [GO:0044212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15697-1; Sequence=Displayed; Name=2; IsoId=Q15697-2; Sequence=VSP_006897, VSP_006898; 


uniprotID: O43298
geneSymbol: ZBTB43
pdb: 2CSH;
length: 467
go: ENSG00000169155;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger and BTB domain-containing protein 43 (Zinc finger and BTB domain-containing protein 22B) (Zinc finger protein 297B) (ZnF-x)

sequence:


uniprotID: Q96CS4
geneSymbol: ZNF689
reactome: R-HSA-212436;
name: Zinc finger protein 689
length: 500
go: ENSG00000156853;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; skeletal muscle cell differentiation [GO:0035914]


uniprotID: Q5VV52
geneSymbol: ZNF691
reactome: R-HSA-212436;
name: Zinc finger protein 691
length: 315
go: ENSG00000164011;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription regulatory region DNA binding [GO:0044212]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5VV52-2; Sequence=Displayed; Name=2; IsoId=Q5VV52-3; Sequence=VSP_018183; Note=No experimental confirmation available.; 


uniprotID: Q96GY0
geneSymbol: ZC2HC1A
name: Zinc finger C2HC domain-containing protein 1A
length: 325
go: ENSG00000104427;
opentargets: metal ion binding [GO:0046872]
snps: rs17850447
sequence:


uniprotID: Q9Y2A4
geneSymbol: ZNF443
reactome: R-HSA-212436;
name: Zinc finger protein 443 (Krueppel-type zinc finger protein ZK1)
length: 671
go: ENSG00000180855;
snps: rs28599549 rs4239550 rs35699767 rs10422063 rs7256321
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; apoptotic process [GO:0006915]


uniprotID: Q86UD4
geneSymbol: ZNF329
name: Zinc finger protein 329
length: 541
go: ENSG00000181894;
snps: rs2279333 rs34255209
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: P52740
geneSymbol: ZNF132
name: Zinc finger protein 132
length: 706
go: ENSG00000131849;
snps: rs1122955 rs1465789
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P52740-1; Sequence=Displayed; Name=2; IsoId=P52740-2; Sequence=VSP_035665; 


uniprotID: Q6ZN57
geneSymbol: ZFP2
reactome: R-HSA-212436;
name: Zinc finger protein 2 homolog (Zfp-2) (Zinc finger protein 751)
length: 461
go: ENSG00000198939;
snps: rs28678700 rs11956147
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O75467
geneSymbol: ZNF324
reactome: R-HSA-212436;
name: Zinc finger protein 324A (Zinc finger protein ZF5128)
length: 553
go: ENSG00000083812;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q6PF04
geneSymbol: ZNF613
reactome: R-HSA-212436;
name: Zinc finger protein 613
length: 617
go: ENSG00000176024;
snps: rs17854933 rs8106409 rs16983243 rs33998555 rs16983253
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6PF04-1; Sequence=Displayed; Name=2; IsoId=Q6PF04-2; Sequence=VSP_018388; Note=No experimental confirmation available.; 


uniprotID: Q86XD8
geneSymbol: ZFAND4
length: 727
go: ENSG00000172671;
opentargets: zinc ion binding [GO:0008270]
snps: rs17854567 rs12267385 rs34082391
name:
AN1-type zinc finger protein 4 (AN1-type zinc finger and ubiquitin domain-containing protein-like 1)

sequence:


uniprotID: Q8TBC5
geneSymbol: ZSCAN18
name: Zinc finger and SCAN domain-containing protein 18 (Zinc finger protein 447)
length: 510
go: ENSG00000121413;
snps: rs2258557
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8TBC5-1; Sequence=Displayed; Name=2; IsoId=Q8TBC5-2; Sequence=VSP_019497; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBC5-3; Sequence=VSP_043272; Note=No experimental confirmation available.; Name=4; IsoId=Q8TBC5-4; Sequence=VSP_047060, VSP_019497; Note=No experimental confirmation available.; 


uniprotID: Q5JVG2
geneSymbol: ZNF484
reactome: R-HSA-212436;
pdb: 2EMF;2EMG;2EMH;2EMI;2EOV;2EP1;2EP2;2EP3;2EQW;2YTJ;2YTO;2YTP;2YTS;
name: Zinc finger protein 484
length: 852
go: ENSG00000127081;
snps: rs3739602
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5JVG2-1; Sequence=Displayed; Name=2; IsoId=Q5JVG2-2; Sequence=VSP_043079; Note=No experimental confirmation available.; Name=3; IsoId=Q5JVG2-3; Sequence=VSP_044922; Note=No experimental confirmation available.; 


uniprotID: Q9C0D3
geneSymbol: ZYG11B
name: Protein zyg-11 homolog B
length: 744
go: ENSG00000162378;
sequence:

opentargets:
Cul2-RING ubiquitin ligase complex [GO:0031462]; ubiquitin-protein transferase activity [GO:0004842]; regulation of ubiquitin-protein transferase activity [GO:0051438]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9C0D3-1; Sequence=Displayed; Name=2; IsoId=Q9C0D3-2; Sequence=VSP_028224; Note=No experimental confirmation available.; 


uniprotID: Q05516
geneSymbol: ZBTB16
reactome: R-HSA-8951664;R-HSA-983168;
pdb: 1BUO;1CS3;
length: 673
go: ENSG00000109906;
snps: rs121434606
name:
Zinc finger and BTB domain-containing protein 16 (Promyelocytic leukemia zinc finger protein) (Zinc finger protein 145) (Zinc finger protein PLZF)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; transcriptional repressor complex [GO:0017053]; distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001206]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; sequence-specific DNA binding [GO:0043565]; anterior/posterior pattern specification [GO:0009952]; apoptotic process [GO:0006915]; cartilage development [GO:0051216]; central nervous system development [GO:0007417]; embryonic digit morphogenesis [GO:0042733]; embryonic hindlimb morphogenesis [GO:0035116]; embryonic pattern specification [GO:0009880]; forelimb morphogenesis [GO:0035136]; hemopoiesis [GO:0030097]; male germ-line stem cell asymmetric division [GO:0048133]; mesonephros development [GO:0001823]; myeloid cell differentiation [GO:0030099]; negative regulation of cell proliferation [GO:0008285]; negative regulation of myeloid cell differentiation [GO:0045638]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cartilage development [GO:0061036]; positive regulation of chondrocyte differentiation [GO:0032332]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of NK T cell differentiation [GO:0051138]; positive regulation of ossification [GO:0045778]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; post-translational protein modification [GO:0043687]; protein localization to nucleus [GO:0034504]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=PLZFB; IsoId=Q05516-1; Sequence=Displayed; Name=PLZFA; IsoId=Q05516-2; Sequence=VSP_006896; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24359566}. Nucleus, Nuclear body {ECO:0000269|PubMed:24359566}.


uniprotID: P17027
geneSymbol: ZNF23
reactome: R-HSA-212436;
length: 643
go: ENSG00000167377;
snps: rs2070832
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 23 (Zinc finger protein 359) (Zinc finger protein 612) (Zinc finger protein KOX16)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P17027-1; Sequence=Displayed; Name=2; IsoId=P17027-2; Sequence=VSP_055936; Note=No experimental confirmation available.; 


uniprotID: Q8IUH4
geneSymbol: ZDHHC13
length: 622
go: ENSG00000177054;
snps: rs2271001 rs12798330
name:
Palmitoyltransferase ZDHHC13 (EC 2.3.1.225) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin-interacting protein HIP3RP) (Putative MAPK-activating protein PM03) (Putative NF-kappa-B-activating protein 209) (Zinc finger DHHC domain-containing protein 13) (DHHC-13)

sequence:

opentargets:
cytoplasmic vesicle membrane [GO:0030659]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; magnesium ion transmembrane transporter activity [GO:0015095]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IUH4-1; Sequence=Displayed; Name=2; IsoId=Q8IUH4-2; Sequence=VSP_010029; Name=3; IsoId=Q8IUH4-3; Sequence=VSP_010028; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9CWU2}; Multi-pass membrane protein {ECO:0000255}. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi vesicles. {ECO:0000250|UniProtKB:Q9CWU2}.


uniprotID: Q99676
geneSymbol: ZNF184
reactome: R-HSA-212436;
name: Zinc finger protein 184
length: 751
go: ENSG00000096654;
snps: rs1883216
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]


uniprotID: Q7L2R6
geneSymbol: ZNF765
name: Zinc finger protein 765
length: 523
go: ENSG00000196417;ENSG00000204604;
snps: rs10425136
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7L2R6-1; Sequence=Displayed; Name=2; IsoId=Q7L2R6-2; Sequence=VSP_034746, VSP_034747; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Gene prediction based on EST data.; Name=3; IsoId=Q7L2R6-3; Sequence=VSP_055629, VSP_055630; Note=No experimental confirmation available.; 


uniprotID: Q9UJL9
geneSymbol: ZFP69B
reactome: R-HSA-212436;
name: Zinc finger protein 69 homolog B (Zinc finger protein 643)
length: 534
go: ENSG00000187801;
snps: rs2272994 rs12407929
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UJL9-1; Sequence=Displayed; Name=2; IsoId=Q9UJL9-2; Sequence=VSP_041647; 


uniprotID: Q9BTP6
geneSymbol: ZBED2
pdb: 2DJR;
name: Zinc finger BED domain-containing protein 2
length: 218
go: ENSG00000177494;
sequence:


uniprotID: Q9NXT0
geneSymbol: ZNF586
reactome: R-HSA-212436;
name: Zinc finger protein 586
length: 402
go: ENSG00000083828;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NXT0-1; Sequence=Displayed; Name=2; IsoId=Q9NXT0-2; Sequence=VSP_043420, VSP_043421; Note=No experimental confirmation available.; Name=3; IsoId=Q9NXT0-3; Sequence=VSP_044808; Note=No experimental confirmation available.; 


uniprotID: Q9H0C1
geneSymbol: ZMYND12
name: Zinc finger MYND domain-containing protein 12
length: 365
go: ENSG00000066185;
opentargets: intracellular [GO:0005622]; metal ion binding [GO:0046872]
snps: rs1034268
sequence:


uniprotID: Q86UQ0
geneSymbol: ZNF589
reactome: R-HSA-212436;
name: Zinc finger protein 589 (Stem cell zinc finger protein 1)
length: 364
go: ENSG00000164048;
snps: rs9847953 rs11718329
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23665872}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; negative regulation of transcription by RNA polymerase II [GO:0000122]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86UQ0-1; Sequence=Displayed; Name=2; Synonyms=SZF1-2; IsoId=Q86UQ0-2; Sequence=VSP_028449, VSP_028450; Note=Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious.; Name=3; Synonyms=SZF1-1; IsoId=Q86UQ0-3; Sequence=VSP_028449, VSP_028450, VSP_028451; Note=Probable target of nonsense-mediated mRNA decay. The proposed CDS is dubious. Isoform produced through aberrant splice sites.; 


uniprotID: Q7Z2W4
geneSymbol: ZC3HAV1
reactome: R-HSA-6802952;
pdb: 2X5Y;4X52;
length: 902
go: ENSG00000105939;
snps: rs2236426 rs2297241 rs2297236 rs3735007
name:
Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cadherin binding [GO:0045296]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; negative regulation of viral genome replication [GO:0045071]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of RIG-I signaling pathway [GO:1900246]; response to virus [GO:0009615]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=ZAPL; IsoId=Q7Z2W4-1; Sequence=Displayed; Name=2; Synonyms=ZAPS; IsoId=Q7Z2W4-2; Sequence=VSP_010269; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z2W4-3; Sequence=VSP_010270, VSP_010271; Note=No experimental confirmation available. {ECO:0000244|PubMed:20068231}; Name=4; IsoId=Q7Z2W4-4; Sequence=VSP_010268; Note=No experimental confirmation available.; Name=5; IsoId=Q7Z2W4-5; Sequence=VSP_010268, VSP_010269; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.


uniprotID: Q9C0D4
geneSymbol: ZNF518B
name: Zinc finger protein 518B
length: 1074
go: ENSG00000178163;
snps: rs10007352 rs10016702 rs9291410
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8TBZ8
geneSymbol: ZNF564
reactome: R-HSA-212436;
name: Zinc finger protein 564
length: 553
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8TF47
geneSymbol: ZFP90
reactome: R-HSA-212436;
name: Zinc finger protein 90 homolog (Zfp-90) (Zinc finger protein 756)
length: 636
go: ENSG00000184939;
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; negative regulation of DNA binding [GO:0043392]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TF47-1; Sequence=Displayed; Name=2; Synonyms=FOXP3-interacting KRAB-domain containing protein, FIK {ECO:0000303|PubMed:23543754}; IsoId=Q8TF47-3; Sequence=VSP_057516, VSP_057517; Note=Interacts (via 75-113 AA) with FOXP3. Interacts (via KRAB domain) with TRIM28. {ECO:0000269|PubMed:23543754}; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q61967}. Note=Colocalizes with REST in the nucleus. {ECO:0000250|UniProtKB:Q61967}.


uniprotID: Q03923
geneSymbol: ZNF85
name: Zinc finger protein 85 (Zinc finger protein HPF4) (Zinc finger protein HTF1)
length: 595
go: ENSG00000105750;
snps: rs7254311 rs56321708 rs56231962 rs56393308 rs11665978 rs1063156 rs11670246
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9839802}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q03923-1; Sequence=Displayed; Name=2; IsoId=Q03923-2; Sequence=VSP_035771; Note=No experimental confirmation available.; Name=3; IsoId=Q03923-3; Sequence=VSP_042154, VSP_042155; 


uniprotID: Q8IYN0
geneSymbol: ZNF100
reactome: R-HSA-212436;
name: Zinc finger protein 100
length: 542
go: ENSG00000197020;
snps: rs12974842 rs7246400
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O60844
geneSymbol: ZG16
pdb: 3APA;3VY6;3VY7;3VZE;3VZF;3VZG;
name: Zymogen granule membrane protein 16 (Zymogen granule protein 16) (hZG16) (Secretory lectin ZG16)
length: 167
snps: rs235636 rs235638
sequence:
MLTVALLALLCASASGNAIQARSSSYSGEYGGGGGKRFSHSGNQLDGPITALRVRVNTYYIVGLQVRYGKVWSDYVGGRNGDLEEIFLHPGESVIQVSGKYKWYLKKLLFVTDKGRYLSFGKDSGTSFNAVPLHPNTVLRFISGRSGSLIDAIGLHWDVYPSSCSRC

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasmic vesicle lumen [GO:0060205]; Golgi lumen [GO:0005796]; zymogen granule membrane [GO:0042589]; carbohydrate binding [GO:0030246]; protein transport [GO:0015031]

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17307141}. Cytoplasmic vesicle lumen {ECO:0000305|PubMed:17307141}. Golgi apparatus lumen {ECO:0000269|PubMed:17307141}. Note=Stored in zymogen granules. {ECO:0000250}.


uniprotID: Q5VIY5
geneSymbol: ZNF468
reactome: R-HSA-212436;
name: Zinc finger protein 468
length: 522
go: ENSG00000204604;
snps: rs12462929 rs10419826
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=ZNF468.1; IsoId=Q5VIY5-1; Sequence=Displayed; Name=2; Synonyms=ZNF468.2; IsoId=Q5VIY5-2; Sequence=VSP_023659; 


uniprotID: Q6ECI4
geneSymbol: ZNF470
reactome: R-HSA-212436;
name: Zinc finger protein 470 (Chondrogenesis zinc finger protein 1) (CZF-1)
length: 717
go: ENSG00000197016;
snps: rs10421285 rs3752179 rs4801177 rs35077804
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15302581}.
sequence:

opentargets:
nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ECI4-1; Sequence=Displayed; Name=2; IsoId=Q6ECI4-2; Sequence=VSP_023660, VSP_023661; Note=No experimental confirmation available.; 


uniprotID: A8K8V0
geneSymbol: ZNF785
reactome: R-HSA-212436;
name: Zinc finger protein 785
length: 405
go: ENSG00000197162;
snps: rs1391888354 rs201574418
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A8K8V0-1; Sequence=Displayed; Name=2; IsoId=A8K8V0-2; Sequence=VSP_034965; Note=No experimental confirmation available.; 


uniprotID: Q8TAW3
geneSymbol: ZNF671
reactome: R-HSA-212436;
name: Zinc finger protein 671
length: 534
go: ENSG00000083814;
snps: rs3746207 rs34419645
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: A6NN14
geneSymbol: ZNF729
reactome: R-HSA-212436;
name: Zinc finger protein 729
length: 1252
go: ENSG00000196350;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9NZV7
geneSymbol: ZIM2
reactome: R-HSA-212436;
name: Zinc finger imprinted 2 (Zinc finger protein 656)
length: 527
go: ENSG00000269699;
snps: rs2191432 rs8112407 rs10422475
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: Q9P0L1
geneSymbol: ZKSCAN7
reactome: R-HSA-212436;
length: 754
go: ENSG00000196345;
snps: rs35696191 rs13081859 rs34396823 rs34181686 rs9835485 rs9873604 rs34437520
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
name:
Zinc finger protein with KRAB and SCAN domains 7 (Zinc finger protein 167) (Zinc finger protein 448) (Zinc finger protein 64)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P0L1-1; Sequence=Displayed; Name=2; IsoId=Q9P0L1-2; Sequence=VSP_011955, VSP_011956; Note=No experimental confirmation available.; 


uniprotID: Q96H79
geneSymbol: ZC3HAV1L
name: Zinc finger CCCH-type antiviral protein 1-like
length: 300
go: ENSG00000146858;
opentargets: cytosol [GO:0005829]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96H79-1; Sequence=Displayed; Name=2; IsoId=Q96H79-2; Sequence=VSP_033210, VSP_033211; Note=No experimental confirmation available.; 


uniprotID: Q6AHZ1
geneSymbol: ZNF518A
name: Zinc finger protein 518A
length: 1483
go: ENSG00000177853;
snps: rs3814228 rs3814226
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6AHZ1-1; Sequence=Displayed; Name=2; IsoId=Q6AHZ1-2; Sequence=VSP_019436; Note=No experimental confirmation available.; 


uniprotID: Q9NX65
geneSymbol: ZSCAN32
reactome: R-HSA-212436;
length: 697
go: ENSG00000140987;
snps: rs17136369 rs27230
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
name:
Zinc finger and SCAN domain-containing protein 32 (Human cervical cancer suppressor gene 5 protein) (HCCS-5) (Zinc finger protein 434)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NX65-1; Sequence=Displayed; Name=2; IsoId=Q9NX65-2; Sequence=VSP_046571; Name=3; IsoId=Q9NX65-3; Sequence=VSP_055988; Note=No experimental confirmation available.; 


uniprotID: P0C7X2
geneSymbol: ZNF688
reactome: R-HSA-212436;
name: Zinc finger protein 688
length: 276
go: ENSG00000229809;
snps: rs33997546
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P0C7X2-1; Sequence=Displayed; Name=2; IsoId=P0C7X2-5; Sequence=VSP_046955; 


uniprotID: Q96SR6
geneSymbol: ZNF382
reactome: R-HSA-212436;
length: 550
go: ENSG00000161298;
snps: rs3108171
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
Zinc finger protein 382 (KRAB/zinc finger suppressor protein 1) (KS1) (Multiple zinc finger and krueppel-associated box protein KS1)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96SR6-1; Sequence=Displayed; Name=2; IsoId=Q96SR6-2; Sequence=VSP_036224; Name=3; IsoId=Q96SR6-3; Sequence=VSP_036225; Note=No experimental confirmation available.; 


uniprotID: O00258
geneSymbol: WRB
length: 174
go: ENSG00000182093;
snps: rs35946782
name:
Tail-anchored protein insertion receptor WRB (Congenital heart disease 5 protein) (Tryptophan-rich basic protein) (WRB)

sequence:
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; nucleus [GO:0005634]; tail-anchored membrane protein insertion into ER membrane [GO:0071816]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00258-1; Sequence=Displayed; Name=2; IsoId=O00258-2; Sequence=VSP_043081; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9544840}; Multi-pass membrane protein {ECO:0000269|PubMed:21444755, ECO:0000269|PubMed:9544840}.


uniprotID: Q8TAG5
geneSymbol: VSTM2A
name: V-set and transmembrane domain-containing protein 2A
length: 236
go: ENSG00000170419;
snps: rs17855529
sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; identical protein binding [GO:0042802]; cell differentiation [GO:0030154]; cellular response to BMP stimulus [GO:0071773]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of white fat cell proliferation [GO:0070352]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TAG5-1; Sequence=Displayed; Name=2; IsoId=Q8TAG5-2; Sequence=VSP_039817; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8R0A6}. Note=Secreted by adipose precursor cells (By similarity). Not detected in the nucleus (PubMed:28052263). {ECO:0000250|UniProtKB:Q8R0A6}.


uniprotID: Q96GT9
geneSymbol: XAGE2
length: 111
go: ENSG00000155622;
name:
X antigen family member 2 (XAGE-2) (Cancer/testis antigen 12.2) (CT12.2) (G antigen family D member 3)

sequence:
MSWRGRSTYRPRPRRSLQPPELIGAMLEPTDEEPKEEKPPTKSRNPTPDQKREDDQGAAEIQVPDLEADLQELCQTKTGDGCEGGTDVKGKILPKAEHFKMPEAGEGKSQV


uniprotID: Q8WTP9
geneSymbol: XAGE3
length: 111
go: ENSG00000171402;
name:
X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein)

sequence:
MIWRGRSTYRPRPRRSVPPPELIGPMLEPGDEEPQQEEPPTESRDPAPGQEREEDQGAAETQVPDLEADLQELSQSKTGGECGNGPDDQGKILPKSEQFKMPEGGDRQPQV


uniprotID: Q8IUB3
geneSymbol: WFDC10B
name: Protein WFDC10B
sequence: MAPQTLLLVLVLCVLLLQAQGGYRDKMRMQRIKVCEKRPSIDLCIHHCSYFQKCETNKICCSAFCGNICMSIL
length: 73
go: ENSG00000182931;
opentargets: extracellular region [GO:0005576]; peptidase inhibitor activity [GO:0030414]
snps: rs232729
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=WAP12a; IsoId=Q8IUB3-1; Sequence=Displayed; Name=2; Synonyms=WAP12b; IsoId=Q8IUB3-2; Sequence=VSP_007552; 


uniprotID: P55060
geneSymbol: CSE1L
length: 971
go: ENSG00000124207;
snps: rs2229042 rs3505
name:
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; nuclear export signal receptor activity [GO:0005049]; protein transporter activity [GO:0008565]; Ran GTPase binding [GO:0008536]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; protein export from nucleus [GO:0006611]; protein import into nucleus [GO:0006606]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=A; IsoId=P55060-1; Sequence=Displayed; Name=2; IsoId=P55060-2; Sequence=VSP_001222, VSP_001223; Name=3; IsoId=P55060-3; Sequence=VSP_001224, VSP_001225; Name=4; IsoId=P55060-4; Sequence=VSP_047203; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9323134}. Nucleus {ECO:0000269|PubMed:9323134}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:9323134}.


uniprotID: Q96G27
geneSymbol: WBP1
pdb: 1JMQ;1K5R;
name: WW domain-binding protein 1 (WBP-1)
length: 269
go: ENSG00000239779;
opentargets: WW domain binding [GO:0050699]
sequence:


uniprotID: Q6ZS81
geneSymbol: WDFY4
name: WD repeat- and FYVE domain-containing protein 4
length: 3184
go: ENSG00000128815;
opentargets: integral component of membrane [GO:0016021]
snps: rs7072606 rs12242384 rs2663046
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q6ZS81-1; Sequence=Displayed; Name=2; IsoId=Q6ZS81-2; Sequence=VSP_020750, VSP_020751; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZS81-3; Sequence=VSP_035683, VSP_035684; Name=4; IsoId=Q6ZS81-4; Sequence=VSP_035687; Note=No experimental confirmation available.; Name=5; IsoId=Q6ZS81-5; Sequence=VSP_035685, VSP_035686; Note=No experimental confirmation available.; 


uniprotID: Q5MNZ6
geneSymbol: WDR45B
reactome: R-HSA-1632852;
length: 344
go: ENSG00000141580;
name:
WD repeat domain phosphoinositide-interacting protein 3 (WIPI-3) (WD repeat-containing protein 45-like) (WDR45-like protein) (WD repeat-containing protein 45B) (WIPI49-like protein)

sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; autophagosome assembly [GO:0000045]; autophagy of mitochondrion [GO:0000422]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]


uniprotID: P17861
geneSymbol: XBP1
reactome: R-HSA-381038;R-HSA-381070;R-HSA-381183;
length: 261
go: ENSG00000100219;
name:
X-box-binding protein 1 (XBP-1) (Tax-responsive element-binding protein 5) (TREB-5) [Cleaved into: X-box-binding protein 1, cytoplasmic form; X-box-binding protein 1, luminal form]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; integral component of endoplasmic reticulum membrane [GO:0030176]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enhancer sequence-specific DNA binding [GO:0001158]; estrogen receptor binding [GO:0030331]; protease binding [GO:0002020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin protein ligase binding [GO:0031625]; adipose tissue development [GO:0060612]; angiogenesis [GO:0001525]; ATF6-mediated unfolded protein response [GO:0036500]; autophagy [GO:0006914]; cellular response to amino acid stimulus [GO:0071230]; cellular response to fluid shear stress [GO:0071498]; cellular response to fructose stimulus [GO:0071332]; cellular response to glucose starvation [GO:0042149]; cellular response to glucose stimulus [GO:0071333]; cellular response to insulin stimulus [GO:0032869]; cellular response to interleukin-4 [GO:0071353]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to nutrient [GO:0031670]; cellular response to oxidative stress [GO:0034599]; cellular response to peptide hormone stimulus [GO:0071375]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular triglyceride homeostasis [GO:0035356]; cholesterol homeostasis [GO:0042632]; endoplasmic reticulum unfolded protein response [GO:0030968]; endothelial cell proliferation [GO:0001935]; epithelial cell maturation involved in salivary gland development [GO:0060691]; exocrine pancreas development [GO:0031017]; fatty acid biosynthetic process [GO:0006633]; fatty acid homeostasis [GO:0055089]; immune response [GO:0006955]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; IRE1-mediated unfolded protein response [GO:0036498]; liver development [GO:0001889]; muscle organ development [GO:0007517]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of endoplasmic reticulum unfolded protein response [GO:1900102]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of pathway-restricted SMAD protein phosphorylation [GO:0060394]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron development [GO:0048666]; organelle organization [GO:0006996]; phosphatidylinositol 3-kinase signaling [GO:0014065]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endoplasmic reticulum unfolded protein response [GO:1900103]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of histone methylation [GO:0031062]; positive regulation of immunoglobulin production [GO:0002639]; positive regulation of immunoglobulin secretion [GO:0051024]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of lactation [GO:1903489]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter [GO:1900413]; positive regulation of plasma cell differentiation [GO:1900100]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress [GO:1990440]; positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [GO:0006990]; positive regulation of vascular associated smooth muscle cell migration [GO:1904754]; positive regulation of vascular smooth muscle cell proliferation [GO:1904707]; positive regulation of vascular wound healing [GO:0035470]; protein destabilization [GO:0031648]; protein transport [GO:0015031]; regulation of autophagy [GO:0010506]; regulation of cell growth [GO:0001558]; regulation of protein stability [GO:0031647]; response to endoplasmic reticulum stress [GO:0034976]; response to insulin-like growth factor stimulus [GO:1990418]; sterol homeostasis [GO:0055092]; transcription by RNA polymerase II [GO:0006366]; ubiquitin-dependent protein catabolic process [GO:0006511]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Unprocessed XBP-1 {ECO:0000305}, XBP-1U {ECO:0000303|PubMed:11779464}, XBP1u {ECO:0000303|PubMed:19394296}; IsoId=P17861-1; Sequence=Displayed; Name=2; Synonyms=Processed XBP-1 {ECO:0000305}, XBP-1S {ECO:0000303|PubMed:11779464}, XBP1s {ECO:0000303|PubMed:19394296}; IsoId=P17861-2; Sequence=VSP_012936; Note=Potent transcriptional activator. Induced by unconventional ERN1-dependent splicing in response to endoplasmic reticulum stress (Ref.4, Ref.18, Ref.19). ENR1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript (Ref.4). {ECO:0000269|PubMed:11779464, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:19622636}; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23529610}. Note=Colocalizes with ERN1 and KDR in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000269|PubMed:23529610}.; SUBCELLULAR LOCATION: Isoform 1: Nucleus {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296}. Cytoplasm {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:25190803}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25239945}; Single-pass type II membrane protein {ECO:0000269|PubMed:25239945}. Endoplasmic reticulum membrane {ECO:0000303|PubMed:25239945}; Peripheral membrane protein {ECO:0000303|PubMed:25239945}. Membrane {ECO:0000269|PubMed:19394296}; Peripheral membrane protein {ECO:0000303|PubMed:19394296}. Note=Shows no preferential localization to either the nucleus or the cytoplasm (By similarity). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:16461360). Localizes predominantly at the endoplasmic reticulum membrane as a membrane-spanning protein; whereas may be only marginally localized on the cytosolic side of the ER membrane as a peripheral membrane (PubMed:19394296, PubMed:25190803). {ECO:0000250|UniProtKB:O35426, ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:25190803}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:16461360, ECO:0000269|PubMed:19394296, ECO:0000269|PubMed:20348923, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000250|UniProtKB:O35426}. Note=Localizes predominantly in the nucleus. Colocalizes in the nucleus with SIRT1. Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (By similarity). {ECO:0000250|UniProtKB:O35426}.; SUBCELLULAR LOCATION: X-box-binding protein 1, cytoplasmic form: Cytoplasm {ECO:0000269|PubMed:25239945}. Nucleus {ECO:0000269|PubMed:25239945}. Note=Localizes in the cytoplasm and nucleus after HM13/SPP-mediated intramembranaire proteolytic cleavage of isoform 1 (PubMed:25239945). {ECO:0000269|PubMed:25239945}.


uniprotID: Q5GH76
geneSymbol: XKR4
name: XK-related protein 4
length: 650
go: ENSG00000206579;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q5GH73
geneSymbol: XKR6
name: XK-related protein 6
length: 641
go: ENSG00000171044;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5GH73-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q5GH73-2; Sequence=VSP_014663; Note=No experimental confirmation available.; 


uniprotID: Q9BYP7
geneSymbol: WNK3
reactome: R-HSA-2672351;
pdb: 5NKP;5O1V;5O21;5O23;5O26;5O2B;5O2C;
length: 1800
go: ENSG00000196632;
snps: rs56077971 rs56404148 rs55903619 rs55879434
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16501604}.
name:
Serine/threonine-protein kinase WNK3 (EC 2.7.11.1) (Protein kinase lysine-deficient 3) (Protein kinase with no lysine 3)

sequence:

opentargets:
adherens junction [GO:0005912]; bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; chloride channel inhibitor activity [GO:0019869]; potassium channel inhibitor activity [GO:0019870]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; intracellular signal transduction [GO:0035556]; ion homeostasis [GO:0050801]; negative regulation of apoptotic process [GO:0043066]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of sodium ion transport [GO:0010766]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of potassium ion import [GO:1903288]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of sodium ion transport [GO:0010765]; protein autophosphorylation [GO:0046777]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of calcium ion import [GO:0090279]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9BYP7-1; Sequence=Displayed; Name=2; IsoId=Q9BYP7-2; Sequence=VSP_041933; Note=No experimental confirmation available.; Name=3; IsoId=Q9BYP7-3; Sequence=VSP_041932, VSP_041933; Name=4; IsoId=Q9BYP7-4; Sequence=VSP_041932; 


uniprotID: Q9P1Q0
geneSymbol: VPS54
reactome: R-HSA-6811440;
length: 977
go: ENSG00000143952;
snps: rs34015596 rs11558741
name:
Vacuolar protein sorting-associated protein 54 (Hepatocellular carcinoma protein 8) (Tumor antigen HOM-HCC-8) (Tumor antigen SLP-8p)

sequence:

opentargets:
cytosol [GO:0005829]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; syntaxin binding [GO:0019905]; Golgi to vacuole transport [GO:0006896]; homeostasis of number of cells within a tissue [GO:0048873]; lysosomal transport [GO:0007041]; musculoskeletal movement [GO:0050881]; neurofilament cytoskeleton organization [GO:0060052]; protein transport [GO:0015031]; regulation of growth [GO:0040008]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9P1Q0-1; Sequence=Displayed; Name=2; IsoId=Q9P1Q0-2; Sequence=VSP_013756; Note=No experimental confirmation available.; Name=3; IsoId=Q9P1Q0-3; Sequence=VSP_013752, VSP_013754, VSP_013755; Note=No experimental confirmation available.; Name=4; IsoId=Q9P1Q0-4; Sequence=VSP_013753; Name=5; IsoId=Q9P1Q0-5; Sequence=VSP_013751; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18367545, ECO:0000269|PubMed:25799061}.


uniprotID: Q8TF74
geneSymbol: WIPF2
reactome: R-HSA-2029482;R-HSA-5663213;
length: 440
go: ENSG00000171475;
name:
WAS/WASL-interacting protein family member 2 (WASP-interacting protein-related protein) (WIP- and CR16-homologous protein) (WIP-related protein)

sequence:

opentargets:
actin cortical patch [GO:0030479]; actin filament [GO:0005884]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; actin filament binding [GO:0051015]; actin cortical patch assembly [GO:0000147]; actin cortical patch localization [GO:0051666]; actin filament-based movement [GO:0030048]; endocytosis [GO:0006897]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; positive regulation of actin nucleation [GO:0051127]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TF74-1; Sequence=Displayed; Name=2; IsoId=Q8TF74-2; Sequence=VSP_012967; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11829459, ECO:0000269|PubMed:12213210}. Note=Localized to stress fibers and bundles of actin filaments.


uniprotID: A3KMH1
geneSymbol: VWA8
name: von Willebrand factor A domain-containing protein 8
length: 1905
go: ENSG00000102763;
opentargets: mitochondrion [GO:0005739]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]
snps: rs9562362 rs3742262 rs17062601 rs9562353 rs41288291 rs2274810
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8CC88}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A3KMH1-1; Sequence=Displayed; Name=2; IsoId=A3KMH1-2; Sequence=VSP_034533; Name=3; IsoId=A3KMH1-3; Sequence=VSP_034532; Note=Incomplete sequence.; 


uniprotID: P41221
geneSymbol: WNT5A
name: Protein Wnt-5a
length: 380
go: ENSG00000114251;
snps: rs786200925 rs387906663
reactome:
R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-3772470;R-HSA-4086398;R-HSA-4086400;R-HSA-4608870;R-HSA-5099900;R-HSA-5140745;R-HSA-8856825;R-HSA-8856828;

sequence:

opentargets:
cell surface [GO:0009986]; clathrin-coated endocytic vesicle membrane [GO:0030669]; clathrin-coated vesicle membrane [GO:0030665]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; chemoattractant activity involved in axon guidance [GO:1902379]; cytokine activity [GO:0005125]; DNA-binding transcription factor activity [GO:0003700]; frizzled binding [GO:0005109]; phospholipid binding [GO:0005543]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; receptor tyrosine kinase-like orphan receptor binding [GO:0005115]; transcription regulatory region DNA binding [GO:0044212]; activation of GTPase activity [GO:0090630]; activation of JUN kinase activity [GO:0007257]; activation of MAPK activity [GO:0000187]; activation of protein kinase B activity [GO:0032148]; anterior/posterior axis specification, embryo [GO:0008595]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; cartilage development [GO:0051216]; cell fate commitment [GO:0045165]; cellular protein localization [GO:0034613]; cellular response to calcium ion [GO:0071277]; cellular response to interferon-gamma [GO:0071346]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cervix development [GO:0060067]; chemoattraction of serotonergic neuron axon [GO:0036517]; chemorepulsion of dopaminergic neuron axon [GO:0036518]; cochlea morphogenesis [GO:0090103]; convergent extension involved in axis elongation [GO:0060028]; convergent extension involved in organogenesis [GO:0060029]; embryonic digit morphogenesis [GO:0042733]; embryonic skeletal system development [GO:0048706]; epithelial cell proliferation involved in mammary gland duct elongation [GO:0060750]; epithelial to mesenchymal transition [GO:0001837]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; excitatory synapse assembly [GO:1904861]; face development [GO:0060324]; genitalia development [GO:0048806]; heart looping [GO:0001947]; hematopoietic stem cell proliferation [GO:0071425]; hindgut morphogenesis [GO:0007442]; hypophysis morphogenesis [GO:0048850]; inhibitory synapse assembly [GO:1904862]; keratinocyte differentiation [GO:0030216]; lateral sprouting involved in mammary gland duct morphogenesis [GO:0060599]; lens development in camera-type eye [GO:0002088]; lung development [GO:0030324]; male gonad development [GO:0008584]; mammary gland branching involved in thelarche [GO:0060744]; melanocyte proliferation [GO:0097325]; membrane organization [GO:0061024]; mesenchymal-epithelial cell signaling [GO:0060638]; mesodermal to mesenchymal transition involved in gastrulation [GO:0060809]; midgut development [GO:0007494]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell proliferation in midbrain [GO:1904934]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of melanin biosynthetic process [GO:0048022]; negative regulation of mesenchymal cell proliferation [GO:0072201]; negative regulation of prostatic bud formation [GO:0060686]; negative regulation of synapse assembly [GO:0051964]; negative regulation of transcription, DNA-templated [GO:0045892]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway [GO:0035567]; non-canonical Wnt signaling pathway via JNK cascade [GO:0038031]; notochord morphogenesis [GO:0048570]; olfactory bulb interneuron development [GO:0021891]; optic cup formation involved in camera-type eye development [GO:0003408]; paraxial mesoderm formation [GO:0048341]; planar cell polarity pathway involved in axis elongation [GO:0003402]; planar cell polarity pathway involved in axon guidance [GO:1904938]; planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [GO:0061350]; planar cell polarity pathway involved in cardiac right atrium morphogenesis [GO:0061349]; planar cell polarity pathway involved in gastrula mediolateral intercalation [GO:0060775]; planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation [GO:1904955]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; planar cell polarity pathway involved in outflow tract morphogenesis [GO:0061347]; planar cell polarity pathway involved in pericardium morphogenesis [GO:0061354]; planar cell polarity pathway involved in ventricular septum morphogenesis [GO:0061348]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cartilage development [GO:0061036]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of cytokine secretion involved in immune response [GO:0002741]; positive regulation of endocytosis [GO:0045807]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 secretion [GO:2000484]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuron death [GO:1901216]; positive regulation of neuron projection arborization [GO:0150012]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of non-canonical Wnt signaling pathway [GO:2000052]; positive regulation of ossification [GO:0045778]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein kinase C activity [GO:1900020]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of response to cytokine stimulus [GO:0060760]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of thymocyte apoptotic process [GO:0070245]; positive regulation of timing of anagen [GO:0051885]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of tumor necrosis factor secretion [GO:1904469]; positive regulation of type I interferon-mediated signaling pathway [GO:0060340]; post-anal tail morphogenesis [GO:0036342]; postsynapse assembly [GO:0099068]; presynapse assembly [GO:0099054]; primitive streak formation [GO:0090009]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; regulation of cellular protein localization [GO:1903827]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; regulation of inflammatory response [GO:0050727]; regulation of postsynapse organization [GO:0099175]; regulation of postsynaptic cytosolic calcium ion concentration [GO:0099566]; regulation of synapse organization [GO:0050807]; response to organic substance [GO:0010033]; secondary palate development [GO:0062009]; somitogenesis [GO:0001756]; type B pancreatic cell development [GO:0003323]; urinary bladder development [GO:0060157]; uterus development [GO:0060065]; vagina development [GO:0060068]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]; wound healing [GO:0042060]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P41221-1; Sequence=Displayed; Name=2; IsoId=P41221-2; Sequence=VSP_035594; 


uniprotID: Q9UBD3
geneSymbol: XCL2
reactome: R-HSA-380108;R-HSA-416476;
name: Cytokine SCM-1 beta (C motif chemokine 2) (XC chemokine ligand 2)
length: 114
go: ENSG00000143185;
snps: rs4301615 rs4501820
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MRLLILALLGICSLTAYIVEGVGSEVSHRRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; blood circulation [GO:0008015]; cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chemokine-mediated signaling pathway [GO:0070098]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; lymphocyte chemotaxis [GO:0048247]; monocyte chemotaxis [GO:0002548]; neutrophil chemotaxis [GO:0030593]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of T cell chemotaxis [GO:0010820]; signal transduction [GO:0007165]


uniprotID: P42768
geneSymbol: WAS
reactome: R-HSA-202433;R-HSA-2029482;R-HSA-5663213;
pdb: 1CEE;1EJ5;1T84;2A3Z;2K42;2OT0;
name: Wiskott-Aldrich syndrome protein (WASp)
length: 502
go: ENSG00000015285;
drug: DB01731;
sequence:

opentargets:
actin cortical patch [GO:0030479]; actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; phagocytic vesicle [GO:0045335]; site of double-strand break [GO:0035861]; vesicle membrane [GO:0012506]; actin filament binding [GO:0051015]; GTPase regulator activity [GO:0030695]; identical protein binding [GO:0042802]; phospholipase binding [GO:0043274]; protein kinase binding [GO:0019901]; Rac GTPase binding [GO:0048365]; SH3 domain binding [GO:0017124]; small GTPase binding [GO:0031267]; actin cortical patch assembly [GO:0000147]; actin cortical patch localization [GO:0051666]; actin filament polymerization [GO:0030041]; actin filament-based movement [GO:0030048]; actin polymerization or depolymerization [GO:0008154]; blood coagulation [GO:0007596]; Cdc42 protein signal transduction [GO:0032488]; cellular response to interferon-gamma [GO:0071346]; defense response [GO:0006952]; endocytosis [GO:0006897]; endosomal transport [GO:0016197]; epidermis development [GO:0008544]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; immune response [GO:0006955]; negative regulation of cell motility [GO:2000146]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of actin nucleation [GO:0051127]; positive regulation of Arp2/3 complex-mediated actin nucleation [GO:2000601]; positive regulation of double-strand break repair via homologous recombination [GO:1905168]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein-containing complex assembly [GO:0065003]; regulation of actin polymerization or depolymerization [GO:0008064]; regulation of lamellipodium assembly [GO:0010591]; regulation of stress fiber assembly [GO:0051492]; regulation of T cell antigen processing and presentation [GO:0002625]; T cell activation [GO:0042110]; T cell receptor signaling pathway [GO:0050852]

snps:
rs132630273 rs132630269 rs132630275 rs782290433 rs132630272 rs132630268 rs132630268 rs139857045 rs146220228 rs132630274 rs132630276 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8625410}. Nucleus {ECO:0000269|PubMed:20574068, ECO:0000269|PubMed:29925947}.


uniprotID: Q8N9V3
geneSymbol: WDSUB1
name: WD repeat, SAM and U-box domain-containing protein 1
length: 476
opentargets: ubiquitin-protein transferase activity [GO:0004842]
snps: rs16843852 rs17852677 rs7591849
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N9V3-1; Sequence=Displayed; Name=2; IsoId=Q8N9V3-2; Sequence=VSP_023337; Note=No experimental confirmation available.; 


uniprotID: P47989
geneSymbol: XDH
reactome: R-HSA-74259;R-HSA-8851680;
pdb: 2CKJ;2E1Q;
length: 1333
go: ENSG00000158125;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome {ECO:0000250}. Secreted.
name:
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]

sequence:

opentargets:
cytosol [GO:0005829]; extracellular space [GO:0005615]; peroxisome [GO:0005777]; sarcoplasmic reticulum [GO:0016529]; 2 iron, 2 sulfur cluster binding [GO:0051537]; electron transfer activity [GO:0009055]; FAD binding [GO:0071949]; flavin adenine dinucleotide binding [GO:0050660]; iron ion binding [GO:0005506]; molybdopterin cofactor binding [GO:0043546]; protein homodimerization activity [GO:0042803]; xanthine dehydrogenase activity [GO:0004854]; xanthine oxidase activity [GO:0004855]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; lactation [GO:0007595]; negative regulation of endothelial cell differentiation [GO:0045602]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of gene expression [GO:0010629]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of vascular endothelial growth factor signaling pathway [GO:1900747]; negative regulation of vasculogenesis [GO:2001213]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; purine nucleotide catabolic process [GO:0006195]; xanthine catabolic process [GO:0009115]

drug:
DB00041;DB00437;DB00993;DB00958;DB01136;DB00856;DB00515;DB00694;DB00746;DB03328;DB00997;DB03516;DB04854;DB03147;DB04335;DB00583;DB00170;DB01033;DB00157;DB00336;DB05262;DB01168;DB00339;DB00127;DB00831;DB03841;

snps:
rs45447191 rs72549369 rs45523133 rs45469499 rs34929837 rs45577338 rs45491693 rs45442092 rs45442398 rs45448694 rs17323225 rs17011368 rs775646772 rs669884 rs45619033 rs45547640 rs1042036 rs45624433 rs45564939 


uniprotID: A6NLU5
geneSymbol: VSTM2B
name: V-set and transmembrane domain-containing protein 2B
length: 285
go: ENSG00000187135;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9H6Y2
geneSymbol: WDR55
name: WD repeat-containing protein 55
length: 383
go: ENSG00000120314;
opentargets: cytoplasm [GO:0005737]; nucleolus [GO:0005730]; rRNA processing [GO:0006364]
snps: rs34342435 rs2530245 rs2286394 rs35983033
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H6Y2-1; Sequence=Displayed; Name=2; IsoId=Q9H6Y2-2; Sequence=VSP_037275; Note=No experimental confirmation available.; 


uniprotID: P47992
geneSymbol: XCL1
reactome: R-HSA-380108;R-HSA-416476;
pdb: 1J8I;1J9O;2HDM;2JP1;2N54;2NYZ;
length: 114
go: ENSG00000143184;
location: SUBCELLULAR LOCATION: Secreted.
name:
Lymphotactin (ATAC) (C motif chemokine 1) (Cytokine SCM-1) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1)

sequence:
MRLLILALLGICSLTAYIVEGVGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVVRSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

opentargets:
cell [GO:0005623]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; CCR chemokine receptor binding [GO:0048020]; chemokine activity [GO:0008009]; chemokine receptor binding [GO:0042379]; protein homodimerization activity [GO:0042803]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cell-cell signaling [GO:0007267]; cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-1 [GO:0071347]; cellular response to interleukin-4 [GO:0071353]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; chemokine-mediated signaling pathway [GO:0070098]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; killing of cells of other organism [GO:0031640]; lymphocyte chemotaxis [GO:0048247]; mature natural killer cell chemotaxis [GO:0035782]; monocyte chemotaxis [GO:0002548]; negative regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000562]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-2 production [GO:0032703]; negative regulation of T cell cytokine production [GO:0002725]; negative regulation of T-helper 1 cell activation [GO:2000518]; negative regulation of T-helper 1 type immune response [GO:0002826]; negative regulation of transcription, DNA-templated [GO:0045892]; neutrophil chemotaxis [GO:0030593]; positive regulation of B cell chemotaxis [GO:2000538]; positive regulation of CD4-positive, alpha-beta T cell proliferation [GO:2000563]; positive regulation of CD8-positive, alpha-beta T cell proliferation [GO:2000566]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of granzyme A production [GO:2000513]; positive regulation of granzyme B production [GO:0071663]; positive regulation of GTPase activity [GO:0043547]; positive regulation of immunoglobulin production in mucosal tissue [GO:2000558]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of leukocyte chemotaxis [GO:0002690]; positive regulation of natural killer cell chemotaxis [GO:2000503]; positive regulation of neutrophil chemotaxis [GO:0090023]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of T cell chemotaxis [GO:0010820]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of T cell mediated cytotoxicity [GO:0001916]; positive regulation of T-helper 1 cell cytokine production [GO:2000556]; positive regulation of T-helper 2 cell cytokine production [GO:2000553]; positive regulation of thymocyte migration [GO:2000412]; positive regulation of transforming growth factor beta production [GO:0071636]; regulation of inflammatory response [GO:0050727]; release of sequestered calcium ion into cytosol [GO:0051209]; response to virus [GO:0009615]; signal transduction [GO:0007165]


uniprotID: O94967
geneSymbol: WDR47
name: WD repeat-containing protein 47 (Neuronal enriched MAP-interacting protein) (Nemitin)
length: 919
go: ENSG00000085433;
opentargets: cytoplasm [GO:0005737]; microtubule [GO:0005874]; multicellular organism development [GO:0007275]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O94967-1; Sequence=Displayed; Name=2; IsoId=O94967-2; Sequence=VSP_012093; Note=No experimental confirmation available.; Name=3; IsoId=O94967-3; Sequence=VSP_035045; Name=4; IsoId=O94967-4; Sequence=VSP_046727, VSP_035045; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localization along microtubules is mediated by MAP1S. {ECO:0000250}.


uniprotID: A4UGR9
geneSymbol: XIRP2
pdb: 4F14;
length: 3374
go: ENSG00000163092;
name:
Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin)

sequence:

opentargets:
cell junction [GO:0030054]; Z disc [GO:0030018]; actin filament binding [GO:0051015]; alpha-actinin binding [GO:0051393]; actin cytoskeleton organization [GO:0030036]; cardiac muscle tissue morphogenesis [GO:0055008]; cell-cell junction organization [GO:0045216]; ventricular septum development [GO:0003281]

snps:
rs16853305 rs16853306 rs7588159 rs7591107 rs16853309 rs7607246 rs16853326 rs16853328 rs16853329 rs16853330 rs3749002 rs781323589 rs16853331 rs3749003 rs3749004 rs16853333 rs3749005 rs3749006 rs16853344 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=A4UGR9-1; Sequence=Displayed; Name=2; IsoId=A4UGR9-2; Sequence=VSP_030846; Name=3; IsoId=A4UGR9-3; Sequence=VSP_030847, VSP_030848; Name=4; IsoId=A4UGR9-4; Sequence=VSP_035717, VSP_035719, VSP_035720; Name=5; IsoId=A4UGR9-5; Sequence=VSP_035719, VSP_035720; Name=6; IsoId=A4UGR9-6; Sequence=VSP_035717, VSP_035718, VSP_035719, VSP_035720; Name=7; IsoId=A4UGR9-7; Sequence=VSP_030846, VSP_035719, VSP_035720; Name=8; IsoId=A4UGR9-8; Sequence=VSP_035717; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:15454575}. Note=Colocalizes with actin stress fibers. {ECO:0000250}.


uniprotID: Q9Y2I8
geneSymbol: WDR37
name: WD repeat-containing protein 37
length: 494
go: ENSG00000047056;
opentargets: PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]
snps: rs17856557 rs17856556 rs2306407
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y2I8-1; Sequence=Displayed; Name=2; IsoId=Q9Y2I8-2; Sequence=VSP_054011; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y2I8-3; Sequence=VSP_054012, VSP_054013; Note=No experimental confirmation available.; 


uniprotID: Q6ZQQ6
geneSymbol: WDR87
name: WD repeat-containing protein 87 (Testis development protein NYD-SP11)
length: 2873
snps: rs12104280 rs6508750 rs10422056 rs10408510
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZQQ6-1; Sequence=Displayed; Name=2; IsoId=Q6ZQQ6-2; Sequence=VSP_030380; Note=No experimental confirmation available.; 


uniprotID: Q93098
geneSymbol: WNT8B
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-4641262;
name: Protein Wnt-8b
length: 351
go: ENSG00000075290;
snps: rs3793771
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; beta-catenin destruction complex disassembly [GO:1904886]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to retinoic acid [GO:0071300]; determination of dorsal identity [GO:0048263]; gastrulation [GO:0007369]; nervous system development [GO:0007399]; neuron differentiation [GO:0030182]; response to estradiol [GO:0032355]; response to retinoic acid [GO:0032526]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]


uniprotID: A6NIX2
geneSymbol: WTIP
reactome: R-HSA-1234176;
name: Wilms tumor protein 1-interacting protein (WT1-interacting protein)
length: 430
go: ENSG00000142279;
sequence:

opentargets:
adherens junction [GO:0005912]; cell-cell junction [GO:0005911]; nucleus [GO:0005634]; P-body [GO:0000932]; transcription factor complex [GO:0005667]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; cell projection organization [GO:0030030]; cytoskeleton organization [GO:0007010]; gene silencing by miRNA [GO:0035195]; negative regulation of hippo signaling [GO:0035331]; positive regulation of gene silencing by miRNA [GO:2000637]; regulation of cell morphogenesis [GO:0022604]; response to hypoxia [GO:0001666]

location:
SUBCELLULAR LOCATION: Cell junction, adherens junction. Nucleus {ECO:0000250}. Cytoplasm, P-body. Note=Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nucleus. The shift from cell contacts to intracellular plaques starts as early as 1 hour after LPS stimulation and intranuclear localization begins 3 hours after LPS treatment. Maximal nuclear localization is achieved 6 hours after LPS treatment. Nuclear translocation requires dynein motor activity and intact microtubule network (By similarity). Returns to cell-cell contacts 24 hours after LPS stimulation. In the presence of ROR2, localizes to the plasma membrane (By similarity). {ECO:0000250}.


uniprotID: Q01831
geneSymbol: XPC
reactome: R-HSA-3108214;R-HSA-5696394;R-HSA-5696395;
pdb: 2A4J;2GGM;2OBH;2RVB;
length: 940
go: ENSG00000154767;
name:
DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125)

sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleotide-excision repair complex [GO:0000109]; nucleotide-excision repair factor 2 complex [GO:0000111]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; XPC complex [GO:0071942]; bubble DNA binding [GO:0000405]; damaged DNA binding [GO:0003684]; heteroduplex DNA loop binding [GO:0000404]; protein-containing complex binding [GO:0044877]; single-stranded DNA binding [GO:0003697]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; intra-S DNA damage checkpoint [GO:0031573]; mismatch repair [GO:0006298]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; regulation of mitotic cell cycle phase transition [GO:1901990]; response to auditory stimulus [GO:0010996]; response to drug [GO:0042493]; response to UV-B [GO:0010224]; UV-damage excision repair [GO:0070914]

snps:
rs1870134 rs2229089 rs3731063 rs35629274 rs3731126 rs74737358 rs2227999 rs2228000 rs6413541 rs3731130 rs3731130 rs3731139 rs3731140 rs3731152 rs3731177 rs2228001 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q01831-1; Sequence=Displayed; Name=2; IsoId=Q01831-2; Sequence=VSP_046344; Note=No experimental confirmation available.; Name=3; Synonyms=B; IsoId=Q01831-3; Sequence=VSP_055890, VSP_055891; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions.


