# annotation

uniprotID: O14522
geneSymbol: PTPRT
pdb: 2OOQ;
length: 1441
go: ENSG00000196090;
snps: rs2867655 rs17811401 rs749647294 rs370873414 rs761148007 rs199947379
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Receptor-type tyrosine-protein phosphatase T (R-PTP-T) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase rho) (RPTP-rho)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; alpha-catenin binding [GO:0045294]; beta-catenin binding [GO:0008013]; cadherin binding [GO:0045296]; delta-catenin binding [GO:0070097]; gamma-catenin binding [GO:0045295]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; protein tyrosine phosphatase activity [GO:0004725]; STAT family protein binding [GO:0097677]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; cell adhesion [GO:0007155]; cellular response to interleukin-6 [GO:0071354]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of cell migration [GO:0030336]; negative regulation of STAT cascade [GO:1904893]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=3; IsoId=O14522-3; Sequence=Displayed; Name=1; IsoId=O14522-1; Sequence=VSP_040385, VSP_040386; 


uniprotID: Q92729
geneSymbol: PTPRU
reactome: R-HSA-1433557;
length: 1446
go: ENSG00000060656;
snps: rs35332573 rs35745442 rs558954146 rs763868325 rs2235937
name:
Receptor-type tyrosine-protein phosphatase U (R-PTP-U) (EC 3.1.3.48) (Pancreatic carcinoma phosphatase 2) (PCP-2) (Protein-tyrosine phosphatase J) (PTP-J) (hPTP-J) (Protein-tyrosine phosphatase pi) (PTP pi) (Protein-tyrosine phosphatase receptor omicron) (PTP-RO) (Receptor-type protein-tyrosine phosphatase psi) (R-PTP-psi)

sequence:

opentargets:
cell-cell junction [GO:0005911]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; beta-catenin binding [GO:0008013]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; animal organ regeneration [GO:0031100]; cell adhesion [GO:0007155]; cell differentiation [GO:0030154]; homotypic cell-cell adhesion [GO:0034109]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; protein dephosphorylation [GO:0006470]; protein localization to cell surface [GO:0034394]; response to glucocorticoid [GO:0051384]; transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q92729-1; Sequence=Displayed; Name=2; IsoId=Q92729-2; Sequence=VSP_037082; Name=3; IsoId=Q92729-3; Sequence=VSP_037082, VSP_037084; Name=4; Synonyms=PTPRO; IsoId=Q92729-4; Sequence=VSP_037082, VSP_037083, VSP_037085; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:8700514}. Cell membrane {ECO:0000269|PubMed:8700514}; Single-pass type I membrane protein {ECO:0000269|PubMed:8700514}.


uniprotID: P23471
geneSymbol: PTPRZ1
reactome: R-HSA-449836;
pdb: 3JXF;3S97;5AWX;5H08;
length: 2315
go: ENSG00000106278;
snps: rs740965 rs11980387 rs1147504
name:
Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; intrinsic component of plasma membrane [GO:0031226]; perineuronal net [GO:0072534]; plasma membrane [GO:0005886]; synapse [GO:0045202]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; axonogenesis [GO:0007409]; central nervous system development [GO:0007417]; cytokine-mediated signaling pathway [GO:0019221]; hematopoietic progenitor cell differentiation [GO:0002244]; learning or memory [GO:0007611]; oligodendrocyte differentiation [GO:0048709]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]; regulation of oligodendrocyte progenitor proliferation [GO:0070445]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P23471-1; Sequence=Displayed; Name=2; IsoId=P23471-2; Sequence=VSP_054062; Name=3; IsoId=P23471-3; Sequence=VSP_054061, VSP_054062; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250}. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.


uniprotID: Q8NBL1
geneSymbol: POGLUT1
reactome: R-HSA-1912399;
pdb: 5L0R;5L0S;5L0T;5L0U;5L0V;5UB5;
length: 392
go: ENSG00000163389;
snps: rs11556605 rs17852785
name:
Protein O-glucosyltransferase 1 (EC 2.4.1.-) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.26)

sequence:

opentargets:
endoplasmic reticulum lumen [GO:0005788]; glucosyltransferase activity [GO:0046527]; protein xylosyltransferase activity [GO:0030158]; UDP-glucosyltransferase activity [GO:0035251]; UDP-xylosyltransferase activity [GO:0035252]; axial mesoderm development [GO:0048318]; cardiovascular system development [GO:0072358]; gastrulation [GO:0007369]; muscle tissue development [GO:0060537]; paraxial mesoderm development [GO:0048339]; positive regulation of Notch signaling pathway [GO:0045747]; protein O-linked glycosylation [GO:0006493]; protein O-linked glycosylation via serine [GO:0018242]; regulation of gastrulation [GO:0010470]; somitogenesis [GO:0001756]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16524674, ECO:0000269|PubMed:24387993, ECO:0000269|PubMed:27807076}.


uniprotID: A6NDG6
geneSymbol: PGP
reactome: R-HSA-70171;
length: 321
go: ENSG00000184207;
name:
Glycerol-3-phosphate phosphatase (G3PP) (EC 3.1.3.21) (Aspartate-based ubiquitous Mg(2+)-dependent phosphatase) (AUM) (EC 3.1.3.48) (Phosphoglycolate phosphatase) (PGP)

sequence:

opentargets:
cytosol [GO:0005829]; glycerol-1-phosphatase activity [GO:0000121]; glycerol-3-phosphatase activity [GO:0043136]; magnesium ion binding [GO:0000287]; nucleotide phosphatase activity, acting on free nucleotides [GO:0098519]; phosphatase activity [GO:0016791]; phosphoglycolate phosphatase activity [GO:0008967]; phosphoprotein phosphatase activity [GO:0004721]; protein tyrosine phosphatase activity [GO:0004725]; dephosphorylation [GO:0016311]; glycerol biosynthetic process [GO:0006114]; glycerophospholipid metabolic process [GO:0006650]; negative regulation of gluconeogenesis [GO:0045721]; peptidyl-tyrosine dephosphorylation [GO:0035335]; protein dephosphorylation [GO:0006470]


uniprotID: A6NFU8
geneSymbol: PGPEP1L
name: Pyroglutamyl-peptidase 1-like protein (EC 3.4.19.-)
length: 196
go: ENSG00000183571;
opentargets: cysteine-type peptidase activity [GO:0008234]; proteolysis [GO:0006508]
snps: rs2715423 rs1521484
sequence:
MKPRTLVELSKLGLGNETVVQLRTLELPVDYREAKRRVTGIWEDHQPQLVVHVGMDTAAKAIILEQSGKNQGYRDADIRSFWPEGGVCLPGSPDVLESGVCMKAVCKRVAVEGVDVIFSRDAGRYVCDYTYYLSLHHGKGCAALIHVPPLSRGLPASLLGRALRVIIQEMLEEVGKPKHRAQFEENSTMVLPAKGN

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NFU8-1; Sequence=Displayed; Name=2; IsoId=A6NFU8-2; Sequence=VSP_053799; Note=No experimental confirmation available.; 


uniprotID: Q9NXJ5
geneSymbol: PGPEP1
length: 209
go: ENSG00000130517;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Pyroglutamyl-peptidase 1 (EC 3.4.19.3) (5-oxoprolyl-peptidase) (Pyroglutamyl aminopeptidase I) (PAP-I) (Pyroglutamyl-peptidase I) (PGP-I) (Pyrrolidone-carboxylate peptidase)

sequence:

opentargets:
cytosol [GO:0005829]; cysteine-type peptidase activity [GO:0008234]; pyroglutamyl-peptidase activity [GO:0016920]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NXJ5-1; Sequence=Displayed; Name=2; IsoId=Q9NXJ5-2; Sequence=VSP_056472; 


uniprotID: O75594
geneSymbol: PGLYRP1
reactome: R-HSA-6798695;R-HSA-6803157;
pdb: 1YCK;
name: Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S)
length: 196
go: ENSG00000008438;
snps: rs34180629
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}. Cytoplasmic granule {ECO:0000250}.
sequence:
MSRRSMLLAWALPSLLRLGAAQETEDPACCSPIVPRNEWKALASECAQHLSLPLRYVVVSHTAGSSCNTPASCQQQARNVQHYHMKTLGWCDVGYNFLIGEDGLVYEGRGWNFTGAHSGHLWNPMSIGISFMGNYMDRVPTPQAIRAAQGLLACGVAQGALRSNYVLKGHRDVQRTLSPGNQLYHLIQNWPHYRSP

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; phagocytic vesicle lumen [GO:0097013]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan receptor activity [GO:0016019]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; growth of symbiont in host [GO:0044117]; innate immune response [GO:0045087]; killing of cells of other organism [GO:0031640]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; neutrophil degranulation [GO:0043312]; peptidoglycan catabolic process [GO:0009253]; positive regulation of cytolysis in other organism [GO:0051714]


uniprotID: Q8TB72
geneSymbol: PUM2
reactome: R-HSA-8951664;
pdb: 3Q0Q;3Q0R;3Q0S;
name: Pumilio homolog 2 (Pumilio-2)
length: 1066
go: ENSG00000055917;
snps: rs34032508
sequence:

opentargets:
cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; posttranscriptional regulation of gene expression [GO:0010608]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; regulation of chromosome segregation [GO:0051983]; regulation of gene silencing by miRNA [GO:0060964]; regulation of mRNA stability [GO:0043488]; regulation of translation [GO:0006417]; stress granule assembly [GO:0034063]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8TB72-1; Sequence=Displayed; Name=2; IsoId=Q8TB72-2; Sequence=VSP_009319; Name=3; IsoId=Q8TB72-3; Sequence=VSP_009320; Name=4; IsoId=Q8TB72-4; Sequence=VSP_053705, VSP_009320; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:19168546}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19168546}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells. {ECO:0000269|PubMed:25340845}.


uniprotID: Q92696
geneSymbol: RABGGTA
reactome: R-HSA-6803205;R-HSA-8873719;
length: 567
go: ENSG00000100949;
drug: DB07780;DB07841;DB04464;
snps: rs729421
name:
Geranylgeranyl transferase type-2 subunit alpha (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit alpha) (Rab geranyl-geranyltransferase subunit alpha) (Rab GG transferase alpha) (Rab GGTase alpha) (Rab geranylgeranyltransferase subunit alpha)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; protein heterodimerization activity [GO:0046982]; Rab geranylgeranyltransferase activity [GO:0004663]; Rab GTPase binding [GO:0017137]; zinc ion binding [GO:0008270]; cellular protein modification process [GO:0006464]; post-translational protein modification [GO:0043687]; protein geranylgeranylation [GO:0018344]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; visual perception [GO:0007601]


uniprotID: Q9NWQ8
geneSymbol: PAG1
reactome: R-HSA-180292;R-HSA-202427;
length: 432
go: ENSG00000076641;
name:
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)

sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular [GO:0005622]; membrane raft [GO:0045121]; plasma membrane [GO:0005886]; SH2 domain binding [GO:0042169]; SH3/SH2 adaptor activity [GO:0005070]; adaptive immune response [GO:0002250]; intracellular signal transduction [GO:0035556]; negative regulation of T cell activation [GO:0050868]; regulation of T cell activation [GO:0050863]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}. Note=Present in lipid rafts.


uniprotID: Q96KR7
geneSymbol: PHACTR3
name: Phosphatase and actin regulator 3 (Scaffold-associated PP1-inhibiting protein) (Scapinin)
length: 559
go: ENSG00000087495;
snps: rs2277759
sequence:

opentargets:
nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Scapinin 1B; IsoId=Q96KR7-1; Sequence=Displayed; Name=2; Synonyms=Scapinin-L, Scapinin 1C; IsoId=Q96KR7-2; Sequence=VSP_009091; Name=3; Synonyms=Scapinin-S; IsoId=Q96KR7-3; Sequence=VSP_009091, VSP_009092; Name=4; IsoId=Q96KR7-4; Sequence=VSP_044546; 

location:
SUBCELLULAR LOCATION: Nucleus matrix. Note=Localized to the nuclear matrix-intermediate filament scaffold. Isoform 2 is also found in some cytoplasmic extensions.


uniprotID: Q8IZ21
geneSymbol: PHACTR4
name: Phosphatase and actin regulator 4
length: 702
go: ENSG00000204138;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; lamellipodium [GO:0030027]; actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase activator activity [GO:0072542]; actin cytoskeleton organization [GO:0030036]; closure of optic fissure [GO:0061386]; enteric nervous system development [GO:0048484]; negative regulation of integrin-mediated signaling pathway [GO:2001045]; neural crest cell migration [GO:0001755]; neural tube closure [GO:0001843]; positive regulation of catalytic activity [GO:0043085]; regulation of cell cycle [GO:0051726]; Rho protein signal transduction [GO:0007266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8IZ21-1; Sequence=Displayed; Name=2; IsoId=Q8IZ21-2; Sequence=VSP_025437; Name=3; IsoId=Q8IZ21-3; Sequence=VSP_025436; Name=4; IsoId=Q8IZ21-4; Sequence=VSP_039730, VSP_039731; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q99623
geneSymbol: PHB2
reactome: R-HSA-8949664;
length: 299
go: ENSG00000215021;
name:
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity)

sequence:

opentargets:
cell periphery [GO:0071944]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nuclear matrix [GO:0016363]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; amide binding [GO:0033218]; estrogen receptor binding [GO:0030331]; protein C-terminus binding [GO:0008022]; protein N-terminus binding [GO:0047485]; mammary gland alveolus development [GO:0060749]; mammary gland branching involved in thelarche [GO:0060744]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrion organization [GO:0007005]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of intracellular estrogen receptor signaling pathway [GO:0033147]; negative regulation of mammary gland epithelial cell proliferation [GO:0033600]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of cell cycle G1/S phase transition [GO:1902808]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of exit from mitosis [GO:0031536]; protein import into nucleus, translocation [GO:0000060]; protein stabilization [GO:0050821]; regulation of branching involved in mammary gland duct morphogenesis [GO:0060762]; sister chromatid cohesion [GO:0007062]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q99623-1; Sequence=Displayed; Name=2; IsoId=Q99623-2; Sequence=VSP_045311; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O35129}. Cytoplasm {ECO:0000269|PubMed:19496786}. Nucleus {ECO:0000269|PubMed:19496786}.


uniprotID: P78364
geneSymbol: PHC1
pdb: 2L8E;
name: Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1)
length: 1004
go: ENSG00000111752;
snps: rs1049925 rs587777036
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:9121482}.
reactome:
R-HSA-2559580;R-HSA-3108214;R-HSA-3899300;R-HSA-4551638;R-HSA-4570464;R-HSA-4655427;R-HSA-8939243;R-HSA-8943724;R-HSA-8953750;

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; histone ubiquitination [GO:0016574]; multicellular organism development [GO:0007275]; negative regulation of G0 to G1 transition [GO:0070317]


uniprotID: Q86YI8
geneSymbol: PHF13
pdb: 3O70;3O7A;
name: PHD finger protein 13 (Survival time-associated PHD finger protein in ovarian cancer 1) (SPOC1)
length: 300
go: ENSG00000116273;
snps: rs17853850
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; cell division [GO:0051301]; chromatin organization [GO:0006325]; chromosome segregation [GO:0007059]; mitotic cell cycle [GO:0000278]; mitotic chromosome condensation [GO:0007076]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19638409}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19638409}. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.


uniprotID: O94880
geneSymbol: PHF14
name: PHD finger protein 14
length: 888
go: ENSG00000106443;
snps: rs218966
sequence:

opentargets:
nucleus [GO:0005634]; metal ion binding [GO:0046872]; lung alveolus development [GO:0048286]; negative regulation of mesenchymal cell proliferation involved in lung development [GO:2000791]; negative regulation of platelet-derived growth factor receptor-alpha signaling pathway [GO:2000584]; negative regulation of transcription by RNA polymerase II [GO:0000122]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=2;  Name=1; IsoId=O94880-1; Sequence=Displayed; Name=2; IsoId=O94880-2; Sequence=VSP_035999, VSP_036000, VSP_036001; Note=Dubious isoform. Alternative initiation from a downstream AUG is supported by ribosome profiling data. {ECO:0000244|PubMed:20068231, ECO:0000244|PubMed:28112733, ECO:0000305}; 


uniprotID: Q5T6S3
geneSymbol: PHF19
reactome: R-HSA-212300;
pdb: 2E5Q;4BD3;
name: PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)
length: 580
go: ENSG00000119403;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15563832}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; sequence-specific DNA binding [GO:0043565]; chromatin organization [GO:0006325]; negative regulation of gene expression, epigenetic [GO:0045814]; positive regulation of histone H3-K27 methylation [GO:0061087]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=PCL3L, hPCL3L; IsoId=Q5T6S3-1; Sequence=Displayed; Name=2; Synonyms=PCL3S, hPCL3S; IsoId=Q5T6S3-2; Sequence=VSP_031224, VSP_031225; Name=3; IsoId=Q5T6S3-3; Sequence=VSP_031222, VSP_031223; 


uniprotID: Q8WUB8
geneSymbol: PHF10
name: PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135)
length: 498
go: ENSG00000130024;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
histone acetyltransferase complex [GO:0000123]; npBAF complex [GO:0071564]; nuclear chromatin [GO:0000790]; nucleus [GO:0005634]; histone acetyltransferase activity [GO:0004402]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; negative regulation of transcription, DNA-templated [GO:0045892]; nervous system development [GO:0007399]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8WUB8-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q8WUB8-2; Sequence=VSP_013440; Name=3; IsoId=Q8WUB8-3; Sequence=VSP_039090; 


uniprotID: Q96FC7
geneSymbol: PHYHIPL
name: Phytanoyl-CoA hydroxylase-interacting protein-like
length: 376
go: ENSG00000165443;
opentargets: cytoplasm [GO:0005737]
snps: rs2452505
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96FC7-1; Sequence=Displayed; Name=2; IsoId=Q96FC7-2; Sequence=VSP_034067; Name=3; IsoId=Q96FC7-3; Sequence=VSP_034068, VSP_034069; 


uniprotID: Q9BVI0
geneSymbol: PHF20
reactome: R-HSA-3214847;R-HSA-6804757;R-HSA-6804759;R-HSA-69541;
pdb: 2LDM;3P8D;3Q1J;3QII;3SD4;5TAB;5TBN;
length: 1012
go: ENSG00000025293;
snps: rs17431878
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20018852}.
name:
PHD finger protein 20 (Glioma-expressed antigen 2) (Hepatocellular carcinoma-associated antigen 58) (Novel zinc finger protein) (Transcription factor TZP)

sequence:

opentargets:
cytosol [GO:0005829]; histone acetyltransferase complex [GO:0000123]; MLL1 complex [GO:0071339]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; regulation of signal transduction by p53 class mediator [GO:1901796]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BVI0-1; Sequence=Displayed; Name=2; IsoId=Q9BVI0-2; Sequence=VSP_007760, VSP_007761; 


uniprotID: Q8WWQ0
geneSymbol: PHIP
pdb: 3MB3;5ENB;5ENC;5ENE;5ENF;5ENH;5ENI;5ENJ;
length: 1821
go: ENSG00000146247;
snps: rs878854420 rs768324201 rs7747479 rs11547228 rs9350797 rs34841569 rs36048894
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
PH-interacting protein (PHIP) (DDB1- and CUL4-associated factor 14) (IRS-1 PH domain-binding protein) (WD repeat-containing protein 11)

sequence:

opentargets:
nucleus [GO:0005634]; insulin receptor binding [GO:0005158]; lysine-acetylated histone binding [GO:0070577]; cytoskeleton organization [GO:0007010]; insulin receptor signaling pathway [GO:0008286]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway [GO:2001237]; positive regulation of cell proliferation [GO:0008284]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell morphogenesis [GO:0022604]; regulation of cell shape [GO:0008360]; regulation of protein phosphorylation [GO:0001932]; regulation of transcription by RNA polymerase II [GO:0006357]


uniprotID: Q9UPV7
geneSymbol: PHF24
pdb: 1WIL;5XHT;
name: PHD finger protein 24
length: 400
go: ENSG00000122733;
sequence:

opentargets:
metal ion binding [GO:0046872]; detection of mechanical stimulus involved in sensory perception of pain [GO:0050966]; gamma-aminobutyric acid signaling pathway [GO:0007214]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; regulation of synaptic transmission, GABAergic [GO:0032228]


uniprotID: P15735
geneSymbol: PHKG2
reactome: R-HSA-70221;
pdb: 2Y7J;
length: 406
go: ENSG00000156873;
snps: rs137853589 rs752961445 rs137853588 rs767427889 rs34006569 rs759992249
name:
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2)

sequence:

opentargets:
cytosol [GO:0005829]; phosphorylase kinase complex [GO:0005964]; ATP binding [GO:0005524]; calmodulin binding [GO:0005516]; calmodulin-dependent protein kinase activity [GO:0004683]; enzyme binding [GO:0019899]; phosphorylase kinase activity [GO:0004689]; protein serine/threonine kinase activity [GO:0004674]; tau-protein kinase activity [GO:0050321]; generation of precursor metabolites and energy [GO:0006091]; glycogen biosynthetic process [GO:0005978]; glycogen metabolic process [GO:0005977]; positive regulation of glycogen catabolic process [GO:0045819]; protein phosphorylation [GO:0006468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P15735-1; Sequence=Displayed; Name=2; IsoId=P15735-2; Sequence=VSP_041858, VSP_041859; 


uniprotID: Q8IWS0
geneSymbol: PHF6
pdb: 4NN2;4R7A;
name: PHD finger protein 6 (PHD-like zinc finger protein)
length: 365
go: ENSG00000156531;
snps: rs132630299 rs132630298 rs104894918 rs104894917 rs104894919 rs587777489
sequence:

opentargets:
condensed chromosome kinetochore [GO:0000777]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; enzyme binding [GO:0019899]; histone binding [GO:0042393]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; phosphoprotein binding [GO:0051219]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; scaffold protein binding [GO:0097110]; sequence-specific DNA binding [GO:0043565]; tubulin binding [GO:0015631]; blastocyst hatching [GO:0001835]; negative regulation of transcription by RNA polymerase II [GO:0000122]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=PHF6a, PHF6b; IsoId=Q8IWS0-1; Sequence=Displayed; Name=2; IsoId=Q8IWS0-2; Sequence=VSP_009372, VSP_009373, VSP_009374; Note=No experimental confirmation available. {ECO:0000244|PubMed:18669648}; Name=3; IsoId=Q8IWS0-3; Sequence=VSP_053441; Note=No experimental confirmation available.; Name=4; IsoId=Q8IWS0-4; Sequence=VSP_053441, VSP_009373, VSP_009374; Note=No experimental confirmation available.; Name=5; IsoId=Q8IWS0-5; Sequence=VSP_054937; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Note=Nuclear, it particularly localizes to the nucleolus.


uniprotID: Q53GA4
geneSymbol: PHLDA2
length: 152
go: ENSG00000181649;
opentargets: cytoplasm [GO:0005737]; membrane [GO:0016020]; apoptotic process [GO:0006915]
name:
Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)

sequence:
MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDFRSRQERTAPAAPAEDAVAAAAAAPSEPSEPSRPSPQPKPRTP

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.


uniprotID: Q86UU1
geneSymbol: PHLDB1
name: Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha)
length: 1377
go: ENSG00000019144;
sequence:

opentargets:
basal cortex [GO:0045180]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86UU1-1; Sequence=Displayed; Note=Minor.; Name=2; IsoId=Q86UU1-2; Sequence=VSP_016737, VSP_016740; Note=Major.; Name=3; IsoId=Q86UU1-3; Sequence=VSP_016737, VSP_016738, VSP_016739; Note=No experimental confirmation available.; 


uniprotID: Q6NSJ2
geneSymbol: PHLDB3
name: Pleckstrin homology-like domain family B member 3
length: 640
go: ENSG00000176531;
opentargets: enzyme binding [GO:0019899]
snps: rs11083711
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NSJ2-1; Sequence=Displayed; Name=2; IsoId=Q6NSJ2-2; Sequence=VSP_039923, VSP_039924; 


uniprotID: Q8TCT1
geneSymbol: PHOSPHO1
reactome: R-HSA-1483191;R-HSA-1483213;
name: Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)
length: 267
go: ENSG00000173868;
drug: DB00122;
sequence:

opentargets:
cytosol [GO:0005829]; extracellular matrix [GO:0031012]; extracellular membrane-bounded organelle [GO:0065010]; metal ion binding [GO:0046872]; phosphocholine phosphatase activity [GO:0052731]; phosphoethanolamine phosphatase activity [GO:0052732]; pyrophosphatase activity [GO:0016462]; bone mineralization involved in bone maturation [GO:0035630]; endochondral ossification [GO:0001958]; phosphatidylcholine biosynthetic process [GO:0006656]; phosphatidylethanolamine biosynthetic process [GO:0006646]; regulation of bone mineralization [GO:0030500]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TCT1-1; Sequence=Displayed; Name=2; Synonyms=PHOSPHO1-3a; IsoId=Q8TCT1-2; Sequence=VSP_040624; Name=3; IsoId=Q8TCT1-3; Sequence=VSP_045709; Note=No experimental confirmation available.; 


uniprotID: Q9NRX4
geneSymbol: PHPT1
pdb: 2AI6;2HW4;2NMM;2OZW;2OZX;
length: 125
go: ENSG00000054148;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog)

sequence:
MAVADLALIPDVDIDSDGVFKYVLIRVHSAPRSGAPAAESKEIVRGYKWAEYHADIYDKVSGDMQKQGCDCECLGGGRISHQSQDKKIHVYGYSMAYGPAQHAISTEKIKAKYPDYEVTWANDGY

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; calcium channel inhibitor activity [GO:0019855]; ion channel binding [GO:0044325]; protein histidine phosphatase activity [GO:0101006]; negative regulation of ATP citrate synthase activity [GO:2000984]; negative regulation of lyase activity [GO:0051350]; negative regulation of T cell receptor signaling pathway [GO:0050860]; peptidyl-histidine dephosphorylation [GO:0035971]; positive regulation of cell motility [GO:2000147]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; protein dephosphorylation [GO:0006470]; regulation of actin cytoskeleton reorganization [GO:2000249]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NRX4-1; Sequence=Displayed; Name=2; IsoId=Q9NRX4-2; Sequence=VSP_041159; 


uniprotID: Q96FA3
geneSymbol: PELI1
reactome: R-HSA-9020702;R-HSA-937039;R-HSA-975144;
length: 418
go: ENSG00000197329;
name:
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)

sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; protein serine/threonine kinase activity [GO:0004674]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-ubiquitin ligase activity [GO:0034450]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of necroptotic process [GO:0060546]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cytokine production [GO:0001819]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of toll-like receptor 3 signaling pathway [GO:0034141]; positive regulation of toll-like receptor 4 signaling pathway [GO:0034145]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; response to dsRNA [GO:0043331]; response to lipopolysaccharide [GO:0032496]; Toll signaling pathway [GO:0008063]


uniprotID: Q7Z6K3
geneSymbol: PTAR1
name: Protein prenyltransferase alpha subunit repeat-containing protein 1
length: 402
go: ENSG00000188647;
sequence:

opentargets:
cytoplasm [GO:0005737]; protein prenyltransferase activity [GO:0008318]; protein prenylation [GO:0018342]


uniprotID: Q9BRX2
geneSymbol: PELO
pdb: 1X52;5EO3;5LZW;5LZX;5LZY;5LZZ;
name: Protein pelota homolog (EC 3.1.-.-)
length: 385
go: ENSG00000152684;
snps: rs1499280
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell proliferation [GO:0008283]; chromosome organization [GO:0051276]; endoderm development [GO:0007492]; mesenchymal to epithelial transition [GO:0060231]; nonfunctional rRNA decay [GO:0070651]; nuclear-transcribed mRNA catabolic process, no-go decay [GO:0070966]; nuclear-transcribed mRNA catabolic process, non-stop decay [GO:0070481]; positive regulation of BMP signaling pathway [GO:0030513]; ribosome disassembly [GO:0032790]; RNA surveillance [GO:0071025]; stem cell population maintenance [GO:0019827]


uniprotID: P60484
geneSymbol: PTEN
pdb: 1D5R;2KYL;4O1V;5BUG;5BZX;5BZZ;
length: 403
go: ENSG00000171862;
reactome:
R-HSA-1660499;R-HSA-1855204;R-HSA-199418;R-HSA-202424;R-HSA-5628897;R-HSA-5674404;R-HSA-5689880;R-HSA-5689896;R-HSA-8943723;R-HSA-8948747;R-HSA-8948751;

name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; mitochondrion [GO:0005739]; myelin sheath adaxonal region [GO:0035749]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; PML body [GO:0016605]; postsynaptic cytosol [GO:0099524]; postsynaptic membrane [GO:0045211]; Schmidt-Lanterman incisure [GO:0043220]; anaphase-promoting complex binding [GO:0010997]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity [GO:0051717]; ionotropic glutamate receptor binding [GO:0035255]; lipid binding [GO:0008289]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; phosphatidylinositol-3-phosphatase activity [GO:0004438]; phosphoprotein phosphatase activity [GO:0004721]; platelet-derived growth factor receptor binding [GO:0005161]; protein serine/threonine phosphatase activity [GO:0004722]; protein tyrosine kinase binding [GO:1990782]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; ubiquitin-specific protease binding [GO:1990381]; adult behavior [GO:0030534]; aging [GO:0007568]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; brain morphogenesis [GO:0048854]; canonical Wnt signaling pathway [GO:0060070]; cardiac muscle tissue development [GO:0048738]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cellular response to electrical stimulus [GO:0071257]; cellular response to ethanol [GO:0071361]; cellular response to hypoxia [GO:0071456]; cellular response to insulin stimulus [GO:0032869]; cellular response to insulin-like growth factor stimulus [GO:1990314]; cellular response to leptin stimulus [GO:0044320]; cellular response to nerve growth factor stimulus [GO:1990090]; central nervous system development [GO:0007417]; central nervous system myelin maintenance [GO:0032286]; central nervous system neuron axonogenesis [GO:0021955]; dendritic spine morphogenesis [GO:0060997]; dentate gyrus development [GO:0021542]; endothelial cell migration [GO:0043542]; forebrain morphogenesis [GO:0048853]; heart development [GO:0007507]; inositol phosphate dephosphorylation [GO:0046855]; inositol phosphate metabolic process [GO:0043647]; learning or memory [GO:0007611]; locomotor rhythm [GO:0045475]; locomotory behavior [GO:0007626]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; male mating behavior [GO:0060179]; maternal behavior [GO:0042711]; memory [GO:0007613]; multicellular organismal response to stress [GO:0033555]; negative regulation of apoptotic process [GO:0043066]; negative regulation of axon regeneration [GO:0048681]; negative regulation of axonogenesis [GO:0050771]; negative regulation of cardiac muscle cell proliferation [GO:0060044]; negative regulation of cell aging [GO:0090344]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of cell size [GO:0045792]; negative regulation of dendritic spine morphogenesis [GO:0061002]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of excitatory postsynaptic potential [GO:0090394]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of keratinocyte migration [GO:0051548]; negative regulation of myelination [GO:0031642]; negative regulation of organ growth [GO:0046621]; negative regulation of phagocytosis [GO:0050765]; negative regulation of phosphatidylinositol 3-kinase signaling [GO:0014067]; negative regulation of potassium ion transmembrane transporter activity [GO:1901017]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of ribosome biogenesis [GO:0090071]; negative regulation of signaling receptor activity [GO:2000272]; negative regulation of synaptic vesicle clustering [GO:2000808]; negative regulation of vascular smooth muscle cell proliferation [GO:1904706]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; neuron-neuron synaptic transmission [GO:0007270]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol dephosphorylation [GO:0046856]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of cardiac muscle cell apoptotic process [GO:0010666]; positive regulation of cell proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron differentiation [GO:0045666]; positive regulation of TRAIL-activated apoptotic signaling pathway [GO:1903984]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; postsynaptic density assembly [GO:0097107]; prepulse inhibition [GO:0060134]; presynaptic membrane assembly [GO:0097105]; prostate gland growth [GO:0060736]; protein dephosphorylation [GO:0006470]; protein deubiquitination [GO:0016579]; protein kinase B signaling [GO:0043491]; protein stabilization [GO:0050821]; regulation of B cell apoptotic process [GO:0002902]; regulation of cellular component size [GO:0032535]; regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]; regulation of myeloid cell apoptotic process [GO:0033032]; regulation of neuron projection development [GO:0010975]; regulation of protein stability [GO:0031647]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to activity [GO:0014823]; response to arsenic-containing substance [GO:0046685]; response to ATP [GO:0033198]; response to estradiol [GO:0032355]; response to glucose [GO:0009749]; response to zinc ion [GO:0010043]; rhythmic synaptic transmission [GO:0060024]; social behavior [GO:0035176]; synapse assembly [GO:0007416]; synapse maturation [GO:0060074]

snps:
rs1064794096 rs121909233 rs1064795967 rs886041877 rs121909225 rs786204854 rs786204855 rs786202398 rs121909236 rs398123316 rs398123317 rs121909226 rs121909238 rs587782343 rs121909230 rs139767111 rs121909237 rs121909222 rs786204931 rs121909223 rs121909218 rs786204929 rs121909224 rs121909229 rs397514560 rs121909241 rs587782360 rs786204859 rs1060500126 rs786204863 rs397514559 rs121909221 rs121913293 rs121913294 rs121913294 rs587782316 rs121909234 rs905615413 rs121909235 rs121909240 rs587782350 rs121909239 rs562015640 rs35600253 rs398123314 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=3;  Name=1; Synonyms=55kDa; IsoId=P60484-1; Sequence=Displayed; Name=alpha; Synonyms=70kDa, PTEN-long; IsoId=P60484-2; Sequence=VSP_055420; Note=Produced by alternative initiation at a CTG start codon of isoform 1. May contain a signal peptide at positions 1-21.; Name=3; IsoId=P60484-3; Sequence=VSP_055421, VSP_055422, VSP_055423; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959, ECO:0000269|PubMed:9187108}. Nucleus {ECO:0000269|PubMed:15987703, ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982, ECO:0000269|PubMed:25801959}. Nucleus, PML body {ECO:0000269|PubMed:18716620}. Note=Monoubiquitinated form is nuclear. Nonubiquitinated form is cytoplasmic. Colocalized with PML and USP7 in PML nuclear bodies (PubMed:18716620). XIAP/BIRC4 promotes its nuclear localization (PubMed:19473982). {ECO:0000269|PubMed:18716620, ECO:0000269|PubMed:19473982}.; SUBCELLULAR LOCATION: Isoform alpha: Secreted {ECO:0000269|PubMed:23744781, ECO:0000269|PubMed:24768297}. Note=May be secreted via a classical signal peptide and reenter into cells with the help of a poly-Arg motif.


uniprotID: P11678
geneSymbol: EPX
reactome: R-HSA-6798695;
length: 715
go: ENSG00000121053;
drug: DB01065;
location: SUBCELLULAR LOCATION: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.
name:
Eosinophil peroxidase (EPO) (EC 1.11.1.7) [Cleaved into: Eosinophil peroxidase light chain; Eosinophil peroxidase heavy chain]

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule lumen [GO:0034774]; heme binding [GO:0020037]; metal ion binding [GO:0046872]; peroxidase activity [GO:0004601]; defense response to bacterium [GO:0042742]; defense response to nematode [GO:0002215]; eosinophil migration [GO:0072677]; hydrogen peroxide catabolic process [GO:0042744]; negative regulation of interleukin-10 production [GO:0032693]; negative regulation of interleukin-5 production [GO:0032714]; neutrophil degranulation [GO:0043312]; positive regulation of interleukin-4 production [GO:0032753]; response to oxidative stress [GO:0006979]

snps:
rs34553736 rs11079339 rs11652709 rs35896669 rs35074452 rs121434566 rs33971258 rs35832094 rs35832094 rs35135976 rs35232062 rs35750729 rs34817773 rs33955150 rs2302311 


uniprotID: P14222
geneSymbol: PRF1
name: Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
length: 555
go: ENSG00000180644;
sequence:

opentargets:
cytolytic granule [GO:0044194]; cytosol [GO:0005829]; endosome lumen [GO:0031904]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; wide pore channel activity [GO:0022829]; apoptotic process [GO:0006915]; cellular defense response [GO:0006968]; cytolysis [GO:0019835]; defense response to tumor cell [GO:0002357]; defense response to virus [GO:0051607]; immune response to tumor cell [GO:0002418]; immunological synapse formation [GO:0001771]; positive regulation of killing of cells of other organism [GO:0051712]; protein homooligomerization [GO:0051260]; T cell mediated cytotoxicity [GO:0001913]

snps:
rs35418374 rs35947132 rs139336186 rs12263572 rs104894183 rs28933973 rs28933375 rs104894182 rs28933374 rs104894181 

location:
SUBCELLULAR LOCATION: Cytoplasmic granule lumen. Secreted. Cell membrane; Multi-pass membrane protein. Endosome lumen. Note=Stored in cytoplasmic granules of cytolytic T-lymphocytes and secreted into the cleft between T-lymphocyte and target cell. Inserts into the cell membrane of target cells and forms pores. Membrane insertion and pore formation requires a major conformation change. May be taken up via endocytosis involving clathrin-coated vesicles and accumulate in a first time in large early endosomes.


uniprotID: P41219
geneSymbol: PRPH
name: Peripherin (Neurofilament 4)
length: 470
go: ENSG00000135406;
sequence:

opentargets:
extracellular exosome [GO:0070062]; intermediate filament [GO:0005882]; membrane [GO:0016020]; type III intermediate filament [GO:0045098]; structural molecule activity [GO:0005198]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P41219-1; Sequence=Displayed; Name=2; IsoId=P41219-2; Sequence=VSP_021159; Note=No experimental confirmation available. Gene prediction based on similarity to orthologs.; 


uniprotID: E9PB15
geneSymbol: PTGES3L
name: Putative protein PTGES3L (Prostaglandin E synthase 3-like)
length: 166
sequence:
MFSLPLNCSPDHIRRGSCWGRPQDLKIAAPAWNSKCHPGAGAAMARQHARTLWYDRPRYVFMEFCVEDSTDVHVLIEDHRIVFSCKNADGVELYNEIEFYAKVNSKPVWLSVDFDNWRDWEGDEEMELAHVEHYAELLKKVSTKRPPPAMDDLDDDSDSADDATSN

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; chaperone binding [GO:0051087]; Hsp90 protein binding [GO:0051879]; chaperone-mediated protein complex assembly [GO:0051131]; protein folding [GO:0006457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=E9PB15-1; Sequence=Displayed; Name=2; IsoId=Q9BTE6-2; Sequence=External; Note=Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.; Name=3; IsoId=Q9BTE6-3; Sequence=External; Note=Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.; 


uniprotID: Q14914
geneSymbol: PTGR1
reactome: R-HSA-2142691;R-HSA-2142700;
pdb: 1ZSV;2Y05;
length: 329
go: ENSG00000106853;
drug: DB03461;DB04066;
snps: rs1053959
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Prostaglandin reductase 1 (PRG-1) (EC 1.3.1.-) (15-oxoprostaglandin 13-reductase) (EC 1.3.1.48) (NADP-dependent leukotriene B4 12-hydroxydehydrogenase) (EC 1.3.1.74)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; 2-alkenal reductase [NAD(P)] activity [GO:0032440]; leukotriene metabolic process [GO:0006691]; response to antineoplastic agent [GO:0097327]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14914-1; Sequence=Displayed; Name=2; IsoId=Q14914-2; Sequence=VSP_044652; Note=No experimental confirmation available.; 


uniprotID: Q8N8N7
geneSymbol: PTGR2
reactome: R-HSA-2162123;
pdb: 2VNA;2W4Q;2W98;2ZB4;2ZB7;2ZB8;
length: 351
go: ENSG00000140043;
drug: DB00328;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Prostaglandin reductase 2 (PRG-2) (EC 1.3.1.48) (15-oxoprostaglandin 13-reductase) (Zinc-binding alcohol dehydrogenase domain-containing protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; 13-prostaglandin reductase activity [GO:0036132]; 15-oxoprostaglandin 13-oxidase activity [GO:0047522]; prostaglandin metabolic process [GO:0006693]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=ZADH1b; IsoId=Q8N8N7-1; Sequence=Displayed; Name=2; IsoId=Q8N8N7-2; Sequence=VSP_013526, VSP_013527; Note=No experimental confirmation available.; 


uniprotID: O00541
geneSymbol: PES1
reactome: R-HSA-6791226;
pdb: 2EP8;
name: Pescadillo homolog
length: 588
go: ENSG00000100029;
snps: rs42942 rs11541876 rs34123894
sequence:

opentargets:
condensed chromosome [GO:0000793]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PeBoW complex [GO:0070545]; preribosome, large subunit precursor [GO:0030687]; ribonucleoprotein complex binding [GO:0043021]; RNA binding [GO:0003723]; cell proliferation [GO:0008283]; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000466]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; nucleolus organization [GO:0007000]; protein localization to organelle [GO:0033365]; regulation of cell cycle [GO:0051726]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00541-1; Sequence=Displayed; Name=2; IsoId=O00541-2; Sequence=VSP_013023; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Note=Appears to localize to the periphery of metaphase chromosomes during mitosis and to the prenucleolar bodies that form in mitotic cells prior to the actual nucleoli. {ECO:0000255|HAMAP-Rule:MF_03028}.


uniprotID: P49190
geneSymbol: PTH2R
reactome: R-HSA-373080;R-HSA-418555;
name: Parathyroid hormone 2 receptor (PTH2 receptor)
length: 550
go: ENSG00000144407;
drug: DB05829;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; parathyroid hormone receptor activity [GO:0004991]; peptide hormone binding [GO:0017046]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; positive regulation of cold-induced thermogenesis [GO:0120162]


uniprotID: P01270
geneSymbol: PTH
reactome: R-HSA-373080;R-HSA-418555;
pdb: 1BWX;1ET1;1ET2;1FVY;1HPH;1HPY;1HTH;1ZWA;1ZWB;1ZWD;1ZWE;1ZWF;1ZWG;2L1X;3C4M;
name: Parathyroid hormone (PTH) (Parathormone) (Parathyrin)
length: 115
go: ENSG00000152266;
drug: DB05883;DB04419;
snps: rs104894271 rs104894272
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MIPAKDMAKVMIVMLAICFLTKSDGKSVKKRSVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNFVALGAPLAPRDAGSQRPRKKEDNVLVESHEKSLGEADKADVNVLTKAKSQ

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; hormone activity [GO:0005179]; parathyroid hormone receptor binding [GO:0031856]; peptide hormone receptor binding [GO:0051428]; protein N-terminus binding [GO:0047485]; receptor ligand activity [GO:0048018]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; type 1 parathyroid hormone receptor binding [GO:0031857]; activation of phospholipase C activity [GO:0007202]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; bone mineralization [GO:0030282]; bone resorption [GO:0045453]; calcium ion transport [GO:0006816]; cAMP metabolic process [GO:0046058]; cell-cell signaling [GO:0007267]; cellular calcium ion homeostasis [GO:0006874]; cellular macromolecule biosynthetic process [GO:0034645]; G protein-coupled receptor signaling pathway [GO:0007186]; homeostasis of number of cells within a tissue [GO:0048873]; hormone-mediated apoptotic signaling pathway [GO:0008628]; magnesium ion homeostasis [GO:0010960]; negative regulation of apoptotic process in bone marrow [GO:0071866]; negative regulation of bone mineralization involved in bone maturation [GO:1900158]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of transcription by RNA polymerase II [GO:0000122]; phosphate ion homeostasis [GO:0055062]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cell proliferation in bone marrow [GO:0071864]; positive regulation of glucose import [GO:0046326]; positive regulation of glycogen biosynthetic process [GO:0045725]; positive regulation of inositol phosphate biosynthetic process [GO:0060732]; positive regulation of osteoclast proliferation [GO:0090290]; positive regulation of signal transduction [GO:0009967]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of gene expression [GO:0010468]; response to cadmium ion [GO:0046686]; response to ethanol [GO:0045471]; response to fibroblast growth factor [GO:0071774]; response to lead ion [GO:0010288]; response to parathyroid hormone [GO:0071107]; response to vitamin D [GO:0033280]; Rho protein signal transduction [GO:0007266]; skeletal system development [GO:0001501]


uniprotID: O60683
geneSymbol: PEX10
reactome: R-HSA-8866654;R-HSA-9033241;
length: 326
go: ENSG00000157911;
snps: rs34154371 rs61752095
location: SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
name:
Peroxisome biogenesis factor 10 (Peroxin-10) (Peroxisomal biogenesis factor 10) (Peroxisome assembly protein 10) (RING finger protein 69)

sequence:

opentargets:
integral component of peroxisomal membrane [GO:0005779]; intracellular [GO:0005622]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein C-terminus binding [GO:0008022]; zinc ion binding [GO:0008270]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60683-1; Sequence=Displayed; Name=2; IsoId=O60683-2; Sequence=VSP_005771; Note=No experimental confirmation available.; 


uniprotID: P50542
geneSymbol: PEX5
reactome: R-HSA-8866654;R-HSA-9033241;
pdb: 1FCH;2C0L;2C0M;2J9Q;2W84;3R9A;4BXU;4KXK;4KYO;
length: 639
go: ENSG00000139197;
snps: rs61752138
name:
Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; intracellular [GO:0005622]; membrane [GO:0016020]; peroxisomal matrix [GO:0005782]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; enzyme binding [GO:0019899]; peroxisome matrix targeting signal-1 binding [GO:0005052]; peroxisome targeting sequence binding [GO:0000268]; protein C-terminus binding [GO:0008022]; protein N-terminus binding [GO:0047485]; small GTPase binding [GO:0031267]; negative regulation of protein homotetramerization [GO:1901094]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, docking [GO:0016560]; protein import into peroxisome matrix, translocation [GO:0016561]; protein import into peroxisome membrane [GO:0045046]; protein targeting to peroxisome [GO:0006625]; protein tetramerization [GO:0051262]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P50542-1; Sequence=Displayed; Name=2; IsoId=P50542-2; Sequence=VSP_021880; Name=3; IsoId=P50542-3; Sequence=VSP_024106; Name=4; IsoId=P50542-4; Sequence=VSP_043639; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).


uniprotID: P43088
geneSymbol: PTGFR
reactome: R-HSA-391908;R-HSA-416476;
name: Prostaglandin F2-alpha receptor (PGF receptor) (PGF2-alpha receptor) (Prostanoid FP receptor)
length: 359
go: ENSG00000122420;
drug: DB00905;DB01160;DB00654;DB08819;DB00287;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; prostaglandin F receptor activity [GO:0004958]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cellular response to prostaglandin D stimulus [GO:0071799]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; negative regulation of apoptotic process [GO:0043066]; parturition [GO:0007567]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of gene expression [GO:0010628]; response to estradiol [GO:0032355]; response to lipopolysaccharide [GO:0032496]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=P43088-1; Sequence=Displayed; Name=2; Synonyms=FP(S), VAR-1; IsoId=P43088-2; Sequence=VSP_042025; Name=3; Synonyms=VAR-2; IsoId=P43088-3; Sequence=VSP_053589, VSP_053595; Name=4; Synonyms=VAR-3; IsoId=P43088-4; Sequence=VSP_053588, VSP_053596; Name=5; Synonyms=altFP4, VAR-4; IsoId=P43088-5; Sequence=VSP_053593, VSP_053597; Name=6; Synonyms=VAR-5; IsoId=P43088-6; Sequence=VSP_053591, VSP_053592; Name=7; Synonyms=VAR-6; IsoId=P43088-7; Sequence=VSP_053590, VSP_053594; 


uniprotID: Q13608
geneSymbol: PEX6
reactome: R-HSA-9033241;
length: 980
go: ENSG00000124587;
name:
Peroxisome assembly factor 2 (PAF-2) (Peroxin-6) (Peroxisomal biogenesis factor 6) (Peroxisomal-type ATPase 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; peroxisomal membrane [GO:0005778]; peroxisome [GO:0005777]; photoreceptor cell cilium [GO:0097733]; photoreceptor outer segment [GO:0001750]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, coupled [GO:0042623]; protein C-terminus binding [GO:0008022]; protein-containing complex binding [GO:0044877]; peroxisome organization [GO:0007031]; protein import into peroxisome matrix [GO:0016558]; protein import into peroxisome matrix, translocation [GO:0016561]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]

snps:
rs61752141 rs886037780 rs886037781 rs886037779 rs61753219 rs387906809 rs61753224 rs34324426 rs769896492 rs35830695 rs61753229 rs61753228 rs267608244 rs61753231 rs61753230 rs2274516 rs886037782 rs34551839 rs1129187 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13608-1; Sequence=Displayed; Name=2; IsoId=Q13608-2; Sequence=VSP_057138, VSP_057139; Name=3; IsoId=Q13608-3; Sequence=VSP_057137; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Peroxisome membrane {ECO:0000269|PubMed:11355018}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:26593283}. Note=Associated with peroxisomal membranes. Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). {ECO:0000269|PubMed:26593283}.


uniprotID: Q13882
geneSymbol: PTK6
pdb: 1RJA;2KGT;5D7V;5DA3;5H2U;6CZ2;6CZ3;6CZ4;
name: Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)
length: 451
go: ENSG00000101213;
drug: DB05294;
snps: rs56145017
reactome:
R-HSA-187577;R-HSA-69231;R-HSA-8847993;R-HSA-8849468;R-HSA-8849469;R-HSA-8849470;R-HSA-8849471;R-HSA-8849472;R-HSA-8849473;R-HSA-8849474;R-HSA-8857538;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; ERBB2 signaling pathway [GO:0038128]; intestinal epithelial cell differentiation [GO:0060575]; negative regulation of growth [GO:0045926]; negative regulation of protein tyrosine kinase activity [GO:0061099]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of cell cycle [GO:0045787]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of neuron projection development [GO:0010976]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; tyrosine phosphorylation of STAT protein [GO:0007260]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13882-1; Sequence=Displayed; Name=2; Synonyms=ALT-PTK6, LambdaM5; IsoId=Q13882-2; Sequence=VSP_042066, VSP_042067; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell projection, ruffle. Membrane {ECO:0000250}. Note=Colocalizes with KHDRBS1, KHDRBS2 or KHDRBS3, within the nucleus. Nuclear localization in epithelial cells of normal prostate but cytoplasmic localization in cancer prostate.


uniprotID: Q13308
geneSymbol: PTK7
length: 1070
go: ENSG00000112655;
snps: rs56188167 rs34021075 rs9472017 rs56216742 rs34764696 rs55820547 rs55755163 rs34865794
name:
Inactive tyrosine-protein kinase 7 (Colon carcinoma kinase 4) (CCK-4) (Protein-tyrosine kinase 7) (Pseudo tyrosine kinase receptor 7) (Tyrosine-protein kinase-like 7)

sequence:

opentargets:
cell-cell junction [GO:0005911]; focal adhesion [GO:0005925]; integral component of plasma membrane [GO:0005887]; ATP binding [GO:0005524]; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway [GO:1904929]; protein kinase activity [GO:0004672]; actin cytoskeleton reorganization [GO:0031532]; axis elongation [GO:0003401]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cellular response to retinoic acid [GO:0071300]; cochlea morphogenesis [GO:0090103]; convergent extension [GO:0060026]; coronary vasculature development [GO:0060976]; establishment of epithelial cell apical/basal polarity [GO:0045198]; establishment of planar polarity [GO:0001736]; lung-associated mesenchyme development [GO:0060484]; planar cell polarity pathway involved in neural tube closure [GO:0090179]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of neuron projection development [GO:0010976]; signal transduction [GO:0007165]; ventricular septum development [GO:0003281]; wound healing [GO:0042060]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=PTK7-1; IsoId=Q13308-1; Sequence=Displayed; Name=2; Synonyms=PTK7-2; IsoId=Q13308-2; Sequence=VSP_037182; Name=3; Synonyms=PTK7-3; IsoId=Q13308-3; Sequence=VSP_037181; Name=4; Synonyms=PTK7-4; IsoId=Q13308-4; Sequence=VSP_037183; Name=5; Synonyms=PTK7-5; IsoId=Q13308-5; Sequence=VSP_037184, VSP_037185; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; IsoId=Q13308-6; Sequence=VSP_044775; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:20837484}; Single-pass type I membrane protein {ECO:0000269|PubMed:20837484}. Cell junction {ECO:0000269|PubMed:20837484}. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.


uniprotID: Q15678
geneSymbol: PTPN14
reactome: R-HSA-9008059;
pdb: 2BZL;
name: Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez)
length: 1187
go: ENSG00000152104;
snps: rs112523432 rs12239356
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; transcription coregulator activity [GO:0003712]; cellular response to cytokine stimulus [GO:0071345]; lymphangiogenesis [GO:0001946]; negative regulation of cell proliferation [GO:0008285]; protein dephosphorylation [GO:0006470]; regulation of protein export from nucleus [GO:0046825]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus. Note=Translocation into the nucleus is associated with induction of cell proliferation. Partially colocalized with actin filaments at the plasma membrane.


uniprotID: P18031
geneSymbol: PTPN1
reactome: R-HSA-354192;R-HSA-6807004;R-HSA-877312;R-HSA-8849472;R-HSA-912694;R-HSA-982772;
length: 435
go: ENSG00000196396;
snps: rs16995304 rs16995309
pdb:
1A5Y;1AAX;1BZC;1BZH;1BZJ;1C83;1C84;1C85;1C86;1C87;1C88;1ECV;1EEN;1EEO;1G1F;1G1G;1G1H;1G7F;1G7G;1GFY;1I57;1JF7;1KAK;1KAV;1L8G;1LQF;1NL9;1NNY;1NO6;1NWE;1NWL;1NZ7;1OEM;1OEO;1OES;1OET;1OEU;1OEV;1ONY;1ONZ;1PA1;1PH0;1PTT;1PTU;1PTV;1PTY;1PXH;1PYN;1Q1M;1Q6J;1Q6M;1Q6N;1Q6P;1Q6S;1Q6T;1QXK;1SUG;1T48;1T49;1T4J;1WAX;1XBO;2AZR;2B07;2B4S;2BGD;2BGE;2CM2;2CM3;2CM7;2CM8;2CMA;2CMB;2CMC;2CNE;2CNF;2CNG;2CNH;2CNI;2F6F;2F6T;2F6V;2F6W;2F6Y;2F6Z;2F70;2F71;2FJM;2FJN;2H4G;2H4K;2HB1;2HNP;2HNQ;2NT7;2NTA;2QBP;2QBQ;2QBR;2QBS;2VEU;2VEV;2VEW;2VEX;2VEY;2ZMM;2ZN7;3A5J;3A5K;3CWE;3D9C;3EAX;3EB1;3EU0;3I7Z;3I80;3QKP;3QKQ;3SME;3ZMP;3ZMQ;3ZV2;4BJO;4I8N;4QAH;4QAP;4QBE;4QBW;4Y14;4ZRT;5K9V;5K9W;5KA0;5KA1;5KA2;5KA3;5KA4;5KA7;5KA8;5KA9;5KAA;5KAB;5KAC;5KAD;5T19;6B8E;6B8T;6B8X;6B8Z;6B90;6B95;6BAI;

name:
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)

sequence:

opentargets:
cytoplasmic side of endoplasmic reticulum membrane [GO:0098554]; cytosol [GO:0005829]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; protein-containing complex [GO:0032991]; sorting endosome [GO:0097443]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; ephrin receptor binding [GO:0046875]; insulin receptor binding [GO:0005158]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; protein tyrosine phosphatase activity [GO:0004725]; receptor tyrosine kinase binding [GO:0030971]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; actin cytoskeleton reorganization [GO:0031532]; activation of JUN kinase activity [GO:0007257]; cellular response to unfolded protein [GO:0034620]; endoplasmic reticulum unfolded protein response [GO:0030968]; insulin receptor signaling pathway [GO:0008286]; IRE1-mediated unfolded protein response [GO:0036498]; JAK-STAT cascade involved in growth hormone signaling pathway [GO:0060397]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of insulin receptor signaling pathway [GO:0046627]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of PERK-mediated unfolded protein response [GO:1903898]; negative regulation of signal transduction [GO:0009968]; negative regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030948]; peptidyl-tyrosine dephosphorylation [GO:0035335]; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [GO:1990264]; platelet-derived growth factor receptor-beta signaling pathway [GO:0035791]; positive regulation of IRE1-mediated unfolded protein response [GO:1903896]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of receptor catabolic process [GO:2000646]; protein dephosphorylation [GO:0006470]; regulation of endocytosis [GO:0030100]; regulation of hepatocyte growth factor receptor signaling pathway [GO:1902202]; regulation of intracellular protein transport [GO:0033157]; regulation of signal transduction [GO:0009966]; regulation of type I interferon-mediated signaling pathway [GO:0060338]

drug:
DB08783;DB04800;DB04525;DB02622;DB07295;DB02436;DB01734;DB03483;DB07197;DB06829;DB07130;DB03714;DB07480;DB08001;DB07289;DB08397;DB04001;DB04204;DB02615;DB02014;DB03661;DB05506;DB08003;DB04088;DB02784;DB07651;DB03557;DB02662;DB08371;DB02977;DB02620;DB01133;DB03154;

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.


uniprotID: Q6GMV3
geneSymbol: PTRHD1
length: 140
go: ENSG00000184924;
opentargets: aminoacyl-tRNA hydrolase activity [GO:0004045]
snps: rs781442277 rs1057519631
name:
Putative peptidyl-tRNA hydrolase PTRHD1 (EC 3.1.1.29) (Peptidyl-tRNA hydrolase domain-containing protein 1)

sequence:
MHRGVGPAFRVVRKMAASGAEPQVLVQYLVLRKDLSQAPFSWPAGALVAQACHAATAALHTHRDHPHTAAYLQELGRMRKVVLEAPDETTLKELAETLQQKNIDHMLWLEQPENIATCIALRPYPKEEVGQYLKKFRLFK


uniprotID: O95997
geneSymbol: PTTG1
reactome: R-HSA-174154;R-HSA-174178;R-HSA-2467813;
length: 202
go: ENSG00000164611;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
name:
Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; cysteine-type endopeptidase inhibitor activity [GO:0004869]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; SH3 domain binding [GO:0017124]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; chromosome organization [GO:0051276]; DNA repair [GO:0006281]; homologous chromosome segregation [GO:0045143]; negative regulation of mitotic sister chromatid separation [GO:2000816]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]


uniprotID: Q15124
geneSymbol: PGM5
name: Phosphoglucomutase-like protein 5 (Aciculin) (Phosphoglucomutase-related protein) (PGM-RP)
length: 567
go: ENSG00000154330;
sequence:

opentargets:
cell-cell adherens junction [GO:0005913]; costamere [GO:0043034]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; dystrophin-associated glycoprotein complex [GO:0016010]; focal adhesion [GO:0005925]; intercalated disc [GO:0014704]; sarcolemma [GO:0042383]; spot adherens junction [GO:0005914]; stress fiber [GO:0001725]; Z disc [GO:0030018]; magnesium ion binding [GO:0000287]; phosphoglucomutase activity [GO:0004614]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; galactose catabolic process [GO:0019388]; glucose metabolic process [GO:0006006]; glycogen biosynthetic process [GO:0005978]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15124-1; Sequence=Displayed; Name=2; IsoId=Q15124-2; Sequence=VSP_030014, VSP_030015; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:8175905}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8175905}. Note=Adherens-type cellular junctions. Concentrated in focal contacts at the ends of actin bundles, and associated with actin filaments.


uniprotID: O00264
geneSymbol: PGRMC1
reactome: R-HSA-6798695;
pdb: 4X8Y;
name: Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA)
length: 195
go: ENSG00000101856;
drug: DB00514;DB00540;
sequence:
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND

opentargets:
cell body [GO:0044297]; endoplasmic reticulum [GO:0005783]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; smooth endoplasmic reticulum membrane [GO:0030868]; specific granule membrane [GO:0035579]; synapse [GO:0045202]; amyloid-beta binding [GO:0001540]; heme binding [GO:0020037]; steroid binding [GO:0005496]; neutrophil degranulation [GO:0043312]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00264-1; Sequence=Displayed; Name=2; IsoId=O00264-2; Sequence=VSP_054710; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q95250}; Single-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000303|PubMed:28396637}; Single-pass membrane protein {ECO:0000255}.


uniprotID: P53609
geneSymbol: PGGT1B
length: 377
go: ENSG00000164219;
drug: DB08180;DB07227;DB07841;
snps: rs34918686
name:
Geranylgeranyl transferase type-1 subunit beta (EC 2.5.1.59) (Geranylgeranyl transferase type I subunit beta) (GGTase-I-beta) (Type I protein geranyl-geranyltransferase subunit beta)

sequence:

opentargets:
CAAX-protein geranylgeranyltransferase complex [GO:0005953]; CAAX-protein geranylgeranyltransferase activity [GO:0004662]; drug binding [GO:0008144]; isoprenoid binding [GO:0019840]; peptide binding [GO:0042277]; protein geranylgeranyltransferase activity [GO:0004661]; zinc ion binding [GO:0008270]; negative regulation of nitric-oxide synthase biosynthetic process [GO:0051771]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; protein geranylgeranylation [GO:0018344]; protein prenylation [GO:0018342]; response to cytokine [GO:0034097]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P53609-1; Sequence=Displayed; Name=2; IsoId=P53609-2; Sequence=VSP_021827; Note=No experimental confirmation available.; 


uniprotID: P53611
geneSymbol: RABGGTB
reactome: R-HSA-6803205;R-HSA-8873719;
length: 331
go: ENSG00000137955;
drug: DB07780;DB07841;DB04464;
name:
Geranylgeranyl transferase type-2 subunit beta (EC 2.5.1.60) (Geranylgeranyl transferase type II subunit beta) (GGTase-II-beta) (Rab geranyl-geranyltransferase subunit beta) (Rab GG transferase beta) (Rab GGTase beta) (Rab geranylgeranyltransferase subunit beta) (Type II protein geranyl-geranyltransferase subunit beta)

sequence:

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; Rab-protein geranylgeranyltransferase complex [GO:0005968]; Rab geranylgeranyltransferase activity [GO:0004663]; Rab GTPase binding [GO:0017137]; zinc ion binding [GO:0008270]; cellular protein modification process [GO:0006464]; post-translational protein modification [GO:0043687]; protein geranylgeranylation [GO:0018344]; protein prenylation [GO:0018342]; regulation of apoptotic process [GO:0042981]; visual perception [GO:0007601]


uniprotID: Q8IXK0
geneSymbol: PHC2
name: Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
length: 858
go: ENSG00000134686;
snps: rs10914692 rs12026290
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}.
reactome:
R-HSA-2559580;R-HSA-3108214;R-HSA-3899300;R-HSA-4551638;R-HSA-4570464;R-HSA-4655427;R-HSA-8939243;R-HSA-8943724;

sequence:

opentargets:
heterochromatin [GO:0000792]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8IXK0-1; Sequence=Displayed; Name=2; Synonyms=isoform b; IsoId=Q8IXK0-2; Sequence=VSP_016915; Name=3; IsoId=Q8IXK0-3; Sequence=VSP_016914, VSP_016916, VSP_016917, VSP_016918; Name=4; IsoId=Q8IXK0-4; Sequence=VSP_027217; Note=No experimental confirmation available.; Name=5; IsoId=Q8IXK0-5; Sequence=VSP_039755; Note=No experimental confirmation available.; 


uniprotID: O43189
geneSymbol: PHF1
reactome: R-HSA-212300;
pdb: 2E5P;2M0O;4HCZ;5XFN;5XFO;5XFP;
name: PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)
length: 567
go: ENSG00000112511;
snps: rs6934613 rs3116713
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; sequence-specific DNA binding [GO:0043565]; cellular response to DNA damage stimulus [GO:0006974]; chromatin organization [GO:0006325]; negative regulation of gene expression, epigenetic [GO:0045814]; negative regulation of histone H3-K27 methylation [GO:0061086]; positive regulation of histone H3-K27 methylation [GO:0061087]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; Synonyms=PHF2; IsoId=O43189-1; Sequence=Displayed; Name=1; Synonyms=PHF1; IsoId=O43189-2; Sequence=VSP_004694, VSP_004695; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes specifically to the promoters of numerous target genes. Localizes to double-strand breaks (DSBs) sites following DNA damage. Co-localizes with NEK6 in the centrosome.


uniprotID: O75151
geneSymbol: PHF2
reactome: R-HSA-3214842;
pdb: 3KQI;3PTR;3PU3;3PU8;3PUA;3PUS;
name: Lysine-specific demethylase PHF2 (EC 1.14.11.-) (GRC5) (PHD finger protein 2)
length: 1096
go: ENSG00000197724;
snps: rs34279404 rs35236745
sequence:

opentargets:
condensed chromosome kinetochore [GO:0000777]; kinetochore [GO:0000776]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; dioxygenase activity [GO:0051213]; histone demethylase activity [GO:0032452]; histone demethylase activity (H3-K9 specific) [GO:0032454]; iron ion binding [GO:0005506]; methylated histone binding [GO:0035064]; zinc ion binding [GO:0008270]; liver development [GO:0001889]; negative regulation of chromatin silencing at rDNA [GO:0061188]; protein demethylation [GO:0006482]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:20129925}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.


uniprotID: Q86SQ0
geneSymbol: PHLDB2
name: Pleckstrin homology-like domain family B member 2 (Protein LL5-beta)
length: 1253
go: ENSG00000144824;
snps: rs3749298
sequence:

opentargets:
basal cortex [GO:0045180]; cell leading edge [GO:0031252]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; establishment of protein localization [GO:0045184]; microtubule cytoskeleton organization [GO:0000226]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of stress fiber assembly [GO:0051497]; negative regulation of wound healing, spreading of epidermal cells [GO:1903690]; positive regulation of basement membrane assembly involved in embryonic body morphogenesis [GO:1904261]; regulation of epithelial to mesenchymal transition [GO:0010717]; regulation of gastrulation [GO:0010470]; regulation of microtubule cytoskeleton organization [GO:0070507]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86SQ0-1; Sequence=Displayed; Name=2; IsoId=Q86SQ0-2; Sequence=VSP_016745; Name=3; IsoId=Q86SQ0-3; Sequence=VSP_016744, VSP_016745; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12376540}. Membrane {ECO:0000269|PubMed:12376540}; Peripheral membrane protein {ECO:0000269|PubMed:12376540}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.


uniprotID: Q13371
geneSymbol: PDCL
reactome: R-HSA-6814122;
name: Phosducin-like protein (PHLP)
length: 301
go: ENSG00000136940;
snps: rs4466466
location: SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250|UniProtKB:Q9DBX2}.
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex binding [GO:0044877]; cell projection organization [GO:0030030]; heterotrimeric G-protein complex assembly [GO:1902605]; negative regulation of protein refolding [GO:0061084]; positive regulation of smoothened signaling pathway [GO:0045880]; protein folding [GO:0006457]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; signal transduction [GO:0007165]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13371-1; Sequence=Displayed; Name=2; Synonyms=PhLPs; IsoId=Q13371-2; Sequence=VSP_053571; Note=Expressed ubiquitously, highest levels are found in neural tissues amounting to 10% of total PDCL mRNA.; 


uniprotID: Q8N3S3
geneSymbol: PHTF2
name: Putative homeodomain transcription factor 2
length: 785
go: ENSG00000006576;
opentargets: endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; DNA binding [GO:0003677]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q8N3S3-1; Sequence=Displayed; Name=2; IsoId=Q8N3S3-2; Sequence=VSP_031192; Name=3; IsoId=Q8N3S3-3; Sequence=VSP_031192, VSP_031193; Name=4; IsoId=Q8N3S3-4; Sequence=VSP_031192, VSP_031193, VSP_031194; Name=5; IsoId=Q8N3S3-5; Sequence=VSP_031192, VSP_046275, VSP_046276; Note=No experimental confirmation available. {ECO:0000305}; Name=6; IsoId=Q8N3S3-6; Sequence=VSP_031192, VSP_031193, VSP_046275, VSP_046276; Note=No experimental confirmation available. {ECO:0000305}; Name=7; IsoId=Q8N3S3-7; Sequence=VSP_031192, VSP_031193, VSP_057299, VSP_057300; Note=No experimental confirmation available.; 


uniprotID: Q92561
geneSymbol: PHYHIP
length: 330
go: ENSG00000168490;
snps: rs11547660
name:
Phytanoyl-CoA hydroxylase-interacting protein (Phytanoyl-CoA hydroxylase-associated protein 1) (PAHX-AP1) (PAHXAP1)

sequence:


uniprotID: O43692
geneSymbol: PI15
length: 258
go: ENSG00000137558;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8882727}.
name:
Peptidase inhibitor 15 (PI-15) (25 kDa trypsin inhibitor) (p25TI) (Cysteine-rich secretory protein 8) (CRISP-8) (SugarCrisp)

sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]; multicellular organism development [GO:0007275]


uniprotID: O60331
geneSymbol: PIP5K1C
reactome: R-HSA-1660499;R-HSA-399955;R-HSA-6811558;R-HSA-8856828;
pdb: 2G35;3H1Z;3H85;
length: 668
go: ENSG00000186111;
snps: rs121908315
name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1-gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I gamma) (PIP5KIgamma)

sequence:

opentargets:
cytosol [GO:0005829]; endosome membrane [GO:0010008]; focal adhesion [GO:0005925]; nucleoplasm [GO:0005654]; phagocytic cup [GO:0001891]; presynapse [GO:0098793]; ruffle membrane [GO:0032587]; uropod [GO:0001931]; 1-phosphatidylinositol-3-phosphate 4-kinase activity [GO:0052811]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; ATP binding [GO:0005524]; phosphatidylinositol-3,4-bisphosphate 5-kinase activity [GO:0052812]; actin cytoskeleton organization [GO:0030036]; adherens junction assembly [GO:0034333]; cell-cell adhesion [GO:0098609]; clathrin-dependent endocytosis [GO:0072583]; membrane organization [GO:0061024]; neutrophil chemotaxis [GO:0030593]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; synaptic vesicle endocytosis [GO:0048488]; synaptic vesicle exocytosis [GO:0016079]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PIPKIgamma-90, PIPKIgamma-668, PIPkinIgamma-a, PIPKIgamma_i2; IsoId=O60331-1; Sequence=Displayed; Name=2; Synonyms=variant 700, PIPKIgamma-700, PIPKIgamma_i4; IsoId=O60331-2; Sequence=VSP_042078; Name=3; Synonyms=variant 707, PIPKIgamma-707, PIPKIgamma_i5; IsoId=O60331-3; Sequence=VSP_042080; Name=4; Synonyms=PIPKIgamma-87, PIPKIgamma-640, PIPkinIgamma-b, PIPKIgamma_i1; IsoId=O60331-4; Sequence=VSP_042079; 

location:
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endomembrane system. Cytoplasm. Cell junction, focal adhesion. Cell junction, adherens junction. Cell projection, ruffle membrane. Cell projection, phagocytic cup. Cell projection, uropodium. Note=Detected in plasma membrane invaginations. Isoform 3 is detected in intracellular vesicle-like structures.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus.


uniprotID: P43119
geneSymbol: PTGIR
reactome: R-HSA-391908;R-HSA-392851;R-HSA-418555;
length: 386
go: ENSG00000160013;
drug: DB05229;DB01160;DB01240;DB01088;DB11362;DB00374;
snps: rs2229127 rs28590598
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)

sequence:

opentargets:
cytosol [GO:0005829]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled receptor activity [GO:0004930]; guanyl-nucleotide exchange factor activity [GO:0005085]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; inflammatory response [GO:0006954]; negative regulation of platelet-derived growth factor receptor signaling pathway [GO:0010642]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; response to lipopolysaccharide [GO:0032496]


uniprotID: P48426
geneSymbol: PIP4K2A
reactome: R-HSA-1660499;R-HSA-6811555;R-HSA-6811558;R-HSA-8847453;
pdb: 2YBX;
length: 406
go: ENSG00000150867;
snps: rs11813789 rs2230469
name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)

sequence:

opentargets:
autophagosome [GO:0005776]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-phosphate 4-kinase activity [GO:0052811]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; megakaryocyte development [GO:0035855]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid metabolic process [GO:0006644]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48426-1; Sequence=Displayed; Name=2; IsoId=P48426-2; Sequence=VSP_056458; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light (By similarity). Localization to the nucleus is modulated by the interaction with PIP4K2B. {ECO:0000250}.


uniprotID: Q9NRD5
geneSymbol: PICK1
reactome: R-HSA-202733;R-HSA-416993;
pdb: 2GZV;6AR4;6BJN;6BJO;
length: 415
go: ENSG00000100151;
name:
PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)

sequence:

opentargets:
aggresome [GO:0016235]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic early endosome [GO:0098842]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; trans-Golgi network membrane [GO:0032588]; actin filament binding [GO:0051015]; Arp2/3 complex binding [GO:0071933]; enzyme binding [GO:0019899]; G protein-coupled receptor binding [GO:0001664]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; phospholipid binding [GO:0005543]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; protein kinase C binding [GO:0005080]; signaling receptor binding [GO:0005102]; cellular response to decreased oxygen levels [GO:0036294]; cellular response to glucose starvation [GO:0042149]; dendritic spine maintenance [GO:0097062]; dendritic spine organization [GO:0097061]; DNA methylation involved in embryo development [GO:0043045]; DNA methylation involved in gamete generation [GO:0043046]; glial cell development [GO:0021782]; intracellular protein transport [GO:0006886]; long-term synaptic depression [GO:0060292]; monoamine transport [GO:0015844]; negative regulation of Arp2/3 complex-mediated actin nucleation [GO:0034316]; neuronal ion channel clustering [GO:0045161]; positive regulation of receptor internalization [GO:0002092]; protein kinase C-activating G protein-coupled receptor signaling pathway [GO:0007205]; protein phosphorylation [GO:0006468]; receptor clustering [GO:0043113]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NRD5-1; Sequence=Displayed; Name=2; IsoId=Q9NRD5-2; Sequence=VSP_054902, VSP_054903; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250}.


uniprotID: Q9HB75
geneSymbol: PIDD1
reactome: R-HSA-6803207;
pdb: 2OF5;
length: 910
go: ENSG00000177595;
snps: rs10902221
name:
p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; ion channel complex [GO:0034702]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; death receptor binding [GO:0005123]; volume-sensitive anion channel activity [GO:0005225]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; anion transmembrane transport [GO:0098656]; apoptotic process [GO:0006915]; cellular response to DNA damage stimulus [GO:0006974]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of apoptotic process [GO:0043066]; positive regulation of apoptotic process [GO:0043065]; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902043]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q9HB75-1; Sequence=Displayed; Name=2; IsoId=Q9HB75-2; Sequence=VSP_019671; Name=3; IsoId=Q9HB75-3; Sequence=VSP_019666, VSP_019667; Name=4; IsoId=Q9HB75-4; Sequence=VSP_019665; Name=5; IsoId=Q9HB75-5; Sequence=VSP_019665, VSP_019669, VSP_019672, VSP_019673; Name=6; IsoId=Q9HB75-6; Sequence=VSP_019664, VSP_019669, VSP_019671, VSP_019672, VSP_019673; Name=7; IsoId=Q9HB75-7; Sequence=VSP_019665, VSP_019668, VSP_019670; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16360037, ECO:0000269|PubMed:17159900}. Nucleus {ECO:0000269|PubMed:16360037, ECO:0000269|PubMed:17159900}. Note=Enriched in the nucleus upon DNA damage. {ECO:0000269|PubMed:17159900}.


uniprotID: Q8N8J0
geneSymbol: PI4KAP1
name: Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1
length: 262
sequence:

opentargets:
cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]


uniprotID: Q99755
geneSymbol: PIP5K1A
reactome: R-HSA-1660499;R-HSA-6811558;
length: 562
go: ENSG00000143398;
name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)

sequence:

opentargets:
cytosol [GO:0005829]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; 1-phosphatidylinositol-3-phosphate 4-kinase activity [GO:0052811]; 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; kinase binding [GO:0019900]; phosphatidylinositol-3,4-bisphosphate 5-kinase activity [GO:0052812]; actin cytoskeleton reorganization [GO:0031532]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; cell migration [GO:0016477]; fibroblast migration [GO:0010761]; focal adhesion assembly [GO:0048041]; glycerophospholipid metabolic process [GO:0006650]; keratinocyte differentiation [GO:0030216]; phagocytosis [GO:0006909]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid biosynthetic process [GO:0008654]; positive regulation of glucose import in response to insulin stimulus [GO:2001275]; protein localization to plasma membrane [GO:0072659]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]; ruffle assembly [GO:0097178]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=PIP5KIalpha2; IsoId=Q99755-1; Sequence=Displayed; Name=2; Synonyms=PIP5KIalpha3; IsoId=Q99755-2; Sequence=VSP_016007, VSP_016008; Name=3; IsoId=Q99755-3; Sequence=VSP_016007; Name=4; IsoId=Q99755-4; Sequence=VSP_041912, VSP_041913; 

location:
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm {ECO:0000250}. Nucleus speckle. Cell projection, ruffle. Cell projection, lamellipodium {ECO:0000269|PubMed:15157668}. Nucleus {ECO:0000269|PubMed:15157668}. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs.


uniprotID: Q9Y6X2
geneSymbol: PIAS3
reactome: R-HSA-3232118;R-HSA-3899300;R-HSA-4090294;R-HSA-4615885;R-HSA-4755510;R-HSA-5696395;
pdb: 4MVT;
length: 628
go: ENSG00000131788;
snps: rs17354559
name:
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; dendrite [GO:0030425]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; synapse [GO:0045202]; enzyme binding [GO:0019899]; potassium channel regulator activity [GO:0015459]; protein C-terminus binding [GO:0008022]; protein N-terminus binding [GO:0047485]; SUMO transferase activity [GO:0019789]; zinc ion binding [GO:0008270]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein sumoylation [GO:0033234]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of gene expression [GO:0010628]; positive regulation of membrane potential [GO:0045838]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; response to hormone [GO:0009725]; TNFSF11-mediated signaling pathway [GO:0071847]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54714}. Nucleus {ECO:0000250|UniProtKB:O54714}. Nucleus speckle {ECO:0000250|UniProtKB:O54714}. Note=Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules. {ECO:0000250|UniProtKB:O54714}.


uniprotID: Q8N2W9
geneSymbol: PIAS4
length: 510
go: ENSG00000105229;
reactome:
R-HSA-196791;R-HSA-3108214;R-HSA-3232118;R-HSA-3232142;R-HSA-3899300;R-HSA-4085377;R-HSA-4090294;R-HSA-4615885;R-HSA-4755510;R-HSA-5693565;R-HSA-5693571;R-HSA-5693607;R-HSA-69473;

name:
E3 SUMO-protein ligase PIAS4 (EC 2.3.2.27) (PIASy) (Protein inhibitor of activated STAT protein 4) (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (RING-type E3 ubiquitin transferase PIAS4)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; transferase complex [GO:1990234]; DNA binding [GO:0003677]; protein C-terminus binding [GO:0008022]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [GO:1902231]; positive regulation of keratinocyte apoptotic process [GO:1902174]; positive regulation of protein sumoylation [GO:0033235]; protein sumoylation [GO:0016925]; vitamin D metabolic process [GO:0042359]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000269|PubMed:11248056, ECO:0000269|PubMed:12727872, ECO:0000269|PubMed:15831457}. Note=Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.


uniprotID: Q13492
geneSymbol: PICALM
reactome: R-HSA-432722;R-HSA-8856825;R-HSA-8856828;
length: 652
go: ENSG00000073921;
snps: rs12800974 rs12222608 rs1043858 rs1043859 rs556337
name:
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)

sequence:

opentargets:
cell surface [GO:0009986]; clathrin-coated endocytic vesicle [GO:0045334]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle [GO:0030136]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome to plasma membrane transport vesicle [GO:0070381]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; intrinsic component of membrane [GO:0031224]; membrane [GO:0016020]; neurofibrillary tangle [GO:0097418]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic membrane [GO:0045211]; presynaptic membrane [GO:0042734]; vesicle [GO:0031982]; 1-phosphatidylinositol binding [GO:0005545]; cadherin binding [GO:0045296]; clathrin binding [GO:0030276]; clathrin heavy chain binding [GO:0032050]; low-density lipoprotein particle receptor binding [GO:0050750]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; Rab GTPase binding [GO:0017137]; tau protein binding [GO:0048156]; axonogenesis [GO:0007409]; cargo loading into vesicle [GO:0035459]; cell proliferation [GO:0008283]; clathrin coat assembly [GO:0048268]; clathrin-dependent endocytosis [GO:0072583]; dendrite morphogenesis [GO:0048813]; endosomal transport [GO:0016197]; hemopoiesis [GO:0030097]; iron ion homeostasis [GO:0055072]; iron ion import across plasma membrane [GO:0098711]; learning or memory [GO:0007611]; membrane bending [GO:0097753]; membrane organization [GO:0061024]; modulation of age-related behavioral decline [GO:0090647]; negative regulation of gene expression [GO:0010629]; negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902963]; negative regulation of protein localization to cell surface [GO:2000009]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of receptor-mediated endocytosis [GO:0048261]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of clathrin-dependent endocytosis [GO:2000370]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription, DNA-templated [GO:0045893]; protein-containing complex assembly [GO:0065003]; receptor internalization [GO:0031623]; receptor-mediated endocytosis [GO:0006898]; regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902959]; regulation of endocytosis [GO:0030100]; regulation of protein localization [GO:0032880]; regulation of vesicle size [GO:0097494]; synaptic vesicle maturation [GO:0016188]; transcytosis [GO:0045056]; vesicle budding from membrane [GO:0006900]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=Type I; IsoId=Q13492-1; Sequence=Displayed; Name=2; Synonyms=Type II; IsoId=Q13492-2; Sequence=VSP_004067; Name=3; IsoId=Q13492-3; Sequence=VSP_009607, VSP_009608; Note=No experimental confirmation available.; Name=4; IsoId=Q13492-4; Sequence=VSP_044567, VSP_009607; Note=No experimental confirmation available.; Name=5; IsoId=Q13492-5; Sequence=VSP_044568; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000269|PubMed:10436022}. Golgi apparatus {ECO:0000269|PubMed:10436022}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:10436022}. Nucleus {ECO:0000269|PubMed:16491119}. Note=Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119). {ECO:0000269|PubMed:10436022, ECO:0000269|PubMed:16491119}.


uniprotID: Q8TCI5
geneSymbol: PIFO
name: Protein pitchfork
length: 191
go: ENSG00000173947;
snps: rs150508940 rs15396 rs2184884
sequence:
MCFSRADAADNYPFGTCQQRKLFPHFHPPNLIGNKFVPLRGSPHRGPGCYFSDGYGLAYDLSKIPTSIKGYTLGARTAVRFKPIQKEMTPHAGRYQKVSPQQEKHKQNFAPFNVLVPRFKNYPKDTYYPSPGAYNPEKKPPPKIAWPMKFGSPDWAQVPCLQKRTLKAELSTDKDFRKHRNRVAYLSLYYN

opentargets:
ciliary basal body [GO:0036064]; cytoplasmic vesicle [GO:0031410]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; beta-tubulin binding [GO:0048487]; gamma-tubulin binding [GO:0043015]; kinesin binding [GO:0019894]; protein kinase binding [GO:0019901]; Rab GTPase binding [GO:0017137]; cell projection organization [GO:0030030]; positive regulation of kinase activity [GO:0033674]; regulation of cell projection organization [GO:0031344]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TCI5-1; Sequence=Displayed; Name=2; IsoId=Q8TCI5-2; Sequence=VSP_024557; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCI5-3; Sequence=VSP_042040; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Accumulates specifically at the basal body and ciliary necklace during the early steps of cilia assembly and disassembly, when structural, functional and regulatory proteins are delivered to cilia. At S phase, accumulates in vesicles and declines during mitosis. {ECO:0000250}.


uniprotID: Q9H3S5
geneSymbol: PIGM
reactome: R-HSA-162710;
length: 423
go: ENSG00000143315;
snps: rs12409352
name:
GPI mannosyltransferase 1 (EC 2.4.1.-) (GPI mannosyltransferase I) (GPI-MT-I) (Phosphatidylinositol-glycan biosynthesis class M protein) (PIG-M)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; transferase activity, transferring hexosyl groups [GO:0016758]; GPI anchor biosynthetic process [GO:0006506]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11226175}; Multi-pass membrane protein {ECO:0000269|PubMed:11226175}.


uniprotID: Q8TBF5
geneSymbol: PIGX
reactome: R-HSA-162710;
name: Phosphatidylinositol-glycan biosynthesis class X protein (PIG-X)
length: 258
go: ENSG00000163964;
snps: rs2291397 rs17852091
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; GPI anchor biosynthetic process [GO:0006506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TBF5-1; Sequence=Displayed; Name=2; IsoId=Q8TBF5-2; Sequence=VSP_019842; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.


uniprotID: P57054
geneSymbol: PIGP
reactome: R-HSA-162710;
length: 158
go: ENSG00000185808;
snps: rs2507733 rs768633670 rs16994704 rs2276231
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (EC 2.4.1.198) (Down syndrome critical region protein 5) (Down syndrome critical region protein C) (Phosphatidylinositol-glycan biosynthesis class P protein) (PIG-P)

sequence:
MVPRSTSLTLIVFLFHRLSKAPGKMVENSPSPLPERAIYGFVLFLSSQFGFILYLVWAFIPESWLNSLGLTYWPQKYWAVALPVYLLIAIVIGYVLLFGINMMSTSPLDSIHTITDNYAKNQQQKKYQEEAIPALRDISISEVNQMFFLAAKELYTKN

opentargets:
endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; integral component of membrane [GO:0016021]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=B; IsoId=P57054-1; Sequence=Displayed; Name=A; IsoId=P57054-2; Sequence=VSP_004202; Name=C; Synonyms=DCRC-S; IsoId=P57054-3; Sequence=VSP_004203, VSP_004204; 


uniprotID: Q9UKJ1
geneSymbol: PILRA
reactome: R-HSA-198933;
pdb: 3WUZ;3WV0;4NFB;5XO2;5XOF;
length: 303
go: ENSG00000085514;
snps: rs1859788 rs34266222
name:
Paired immunoglobulin-like type 2 receptor alpha (Cell surface receptor FDF03) (Inhibitory receptor PILR-alpha)

sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; MHC class I protein binding [GO:0042288]; regulation of immune response [GO:0050776]; signal transduction [GO:0007165]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UKJ1-1; Sequence=Displayed; Name=2; IsoId=Q9UKJ1-2; Sequence=VSP_017502; Name=3; Synonyms=FDF03-deltaTM; IsoId=Q9UKJ1-3; Sequence=VSP_017501; Name=4; Synonyms=FDF03-M14; IsoId=Q9UKJ1-4; Sequence=VSP_017500; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 4: Secreted {ECO:0000305}.


uniprotID: P01833
geneSymbol: PIGR
reactome: R-HSA-6798695;
pdb: 1XED;2OCW;3CHN;3CM9;5D4K;
length: 764
go: ENSG00000162896;
snps: rs2275531 rs7542760 rs291102
name:
Polymeric immunoglobulin receptor (PIgR) (Poly-Ig receptor) (Hepatocellular carcinoma-associated protein TB6) [Cleaved into: Secretory component]

sequence:

opentargets:
azurophil granule membrane [GO:0035577]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; polymeric immunoglobulin receptor activity [GO:0001792]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; epidermal growth factor receptor signaling pathway [GO:0007173]; Fc receptor signaling pathway [GO:0038093]; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor [GO:0002415]; neutrophil degranulation [GO:0043312]; receptor clustering [GO:0043113]; retina homeostasis [GO:0001895]

location:
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Secretory component: Secreted.


uniprotID: Q9NQM4
geneSymbol: PIH1D3
name: Protein PIH1D3 (PIH1 domain-containing protein 3) (Sarcoma antigen NY-SAR-97)
length: 214
go: ENSG00000080572;
sequence:

opentargets:
cytoplasm [GO:0005737]; chaperone binding [GO:0051087]; axonemal dynein complex assembly [GO:0070286]; cilium movement [GO:0003341]; flagellated sperm motility [GO:0030317]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3KNI6}. Note=Localized to the cytoplasm of spermatogenic cells. {ECO:0000250|UniProtKB:Q3KNI6}.


uniprotID: Q969N2
geneSymbol: PIGT
reactome: R-HSA-162791;
name: GPI transamidase component PIG-T (Phosphatidylinositol-glycan biosynthesis class T protein)
length: 578
go: ENSG00000124155;
snps: rs587777027 rs36056071
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum membrane [GO:0005789]; GPI-anchor transamidase complex [GO:0042765]; integral component of endoplasmic reticulum membrane [GO:0030176]; membrane [GO:0016020]; GPI-anchor transamidase activity [GO:0003923]; attachment of GPI anchor to protein [GO:0016255]; neuron apoptotic process [GO:0051402]; neuron differentiation [GO:0030182]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q969N2-1; Sequence=Displayed; Name=2; IsoId=Q969N2-2; Sequence=VSP_009537; Name=3; IsoId=Q969N2-3; Sequence=VSP_009536, VSP_009539, VSP_009540; Note=May be due to intron retention. No experimental confirmation available.; Name=4; IsoId=Q969N2-4; Sequence=VSP_009538; Name=5; IsoId=Q969N2-5; Sequence=VSP_043167; Note=No experimental confirmation available.; Name=6; IsoId=Q969N2-6; Sequence=VSP_009540; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11483512}; Single-pass type I membrane protein {ECO:0000269|PubMed:11483512}.


uniprotID: Q9UBM1
geneSymbol: PEMT
reactome: R-HSA-1483191;
length: 199
go: ENSG00000133027;
snps: rs70959686 rs897453 rs897453 rs7946 rs70965427
name:
Phosphatidylethanolamine N-methyltransferase (PEAMT) (PEMT) (EC 2.1.1.17) (EC 2.1.1.71) (PEMT2) (Phospholipid methyltransferase) (PLMT)

sequence:
MTRLLGYVDPLDPSFVAAVITITFNPLYWNVVARWEHKTRKLSRAFGSPYLACYSLSVTILLLNFLRSHCFTQAMLSQPRMESLDTPAAYSLGLALLGLGVVLVLSSFFALGFAGTFLGDYFGILKEARVTVFPFNILDNPMYWGSTANYLGWAIMHASPTGLLLTVLVALTYIVALLYEEPFTAEIYRQKASGSHKRS

opentargets:
brush border membrane [GO:0031526]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; mitochondrial membrane [GO:0031966]; sarcolemma [GO:0042383]; phosphatidyl-N-dimethylethanolamine N-methyltransferase activity [GO:0080101]; phosphatidyl-N-methylethanolamine N-methyltransferase activity [GO:0000773]; phosphatidylethanolamine binding [GO:0008429]; phosphatidylethanolamine N-methyltransferase activity [GO:0004608]; blastocyst hatching [GO:0001835]; cell proliferation [GO:0008283]; lipid metabolic process [GO:0006629]; negative regulation of cell proliferation [GO:0008285]; phosphatidylcholine biosynthetic process [GO:0006656]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of lipoprotein metabolic process [GO:0050747]; response to amino acid [GO:0043200]; response to ethanol [GO:0045471]; response to vitamin [GO:0033273]; S-adenosylhomocysteine metabolic process [GO:0046498]; S-adenosylmethionine metabolic process [GO:0046500]; sphingomyelin biosynthetic process [GO:0006686]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=PEMT-S; IsoId=Q9UBM1-1; Sequence=Displayed; Name=2; Synonyms=PEMT-L; IsoId=Q9UBM1-2; Sequence=VSP_037311; Note=Much lower enzymatic activity than isoform 1. {ECO:0000269|PubMed:20860552}; Name=3; IsoId=Q9UBM1-3; Sequence=VSP_037311, VSP_046034; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20860552}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: P20142
geneSymbol: PGC
pdb: 1AVF;1HTR;
name: Gastricsin (EC 3.4.23.3) (Pepsinogen C)
length: 388
go: ENSG00000096088;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular space [GO:0005615]; aspartic-type endopeptidase activity [GO:0004190]; digestion [GO:0007586]; positive regulation of antibacterial peptide production [GO:0002803]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P20142-1; Sequence=Displayed; Name=2; IsoId=P20142-2; Sequence=VSP_042312; 


uniprotID: O60925
geneSymbol: PFDN1
reactome: R-HSA-389957;
name: Prefoldin subunit 1
length: 122
go: ENSG00000113068;
sequence:
MAAPVDLELKKAFTELQAKVIDTQQKVKLADIQIEQLNRTKKHAHLTDTEIMTLVDETNMYEGVGRMFILQSKEAIHSQLLEKQKIAEEKIKELEQKKSYLERSVKEAEDNIREMLMARRAQ

opentargets:
prefoldin complex [GO:0016272]; DNA-binding transcription factor activity [GO:0003700]; protein binding involved in protein folding [GO:0044183]; unfolded protein binding [GO:0051082]


uniprotID: P17858
geneSymbol: PFKL
reactome: R-HSA-6798695;R-HSA-70171;
length: 780
go: ENSG00000141959;
snps: rs755851304 rs1057037
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
name:
ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)

sequence:

opentargets:
6-phosphofructokinase complex [GO:0005945]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; ficolin-1-rich granule lumen [GO:1904813]; membrane [GO:0016020]; secretory granule lumen [GO:0034774]; 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; fructose binding [GO:0070061]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; canonical glycolysis [GO:0061621]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose catabolic process [GO:0006007]; glycolytic process [GO:0006096]; negative regulation of insulin secretion [GO:0046676]; neutrophil degranulation [GO:0043312]; protein complex oligomerization [GO:0051259]; protein homotetramerization [GO:0051289]; response to glucose [GO:0009749]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P17858-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=P17858-2; Sequence=VSP_011854; Note=No experimental confirmation available.; 


uniprotID: Q01813
geneSymbol: PFKP
reactome: R-HSA-70171;
pdb: 4RH3;4U1R;4WL0;4XYJ;4XYK;4XZ2;
length: 784
go: ENSG00000067057;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.
name:
ATP-dependent 6-phosphofructokinase, platelet type (ATP-PFK) (PFK-P) (EC 2.7.1.11) (6-phosphofructokinase type C) (Phosphofructo-1-kinase isozyme C) (PFK-C) (Phosphohexokinase)

sequence:

opentargets:
6-phosphofructokinase complex [GO:0005945]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleus [GO:0005634]; 6-phosphofructokinase activity [GO:0003872]; AMP binding [GO:0016208]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; fructose-6-phosphate binding [GO:0070095]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; monosaccharide binding [GO:0048029]; protein-containing complex binding [GO:0044877]; canonical glycolysis [GO:0061621]; cellular response to leukemia inhibitory factor [GO:1990830]; fructose 1,6-bisphosphate metabolic process [GO:0030388]; fructose 6-phosphate metabolic process [GO:0006002]; glucose catabolic process [GO:0006007]; protein complex oligomerization [GO:0051259]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q01813-1; Sequence=Displayed; Name=2; IsoId=Q01813-2; Sequence=VSP_046416; Note=No experimental confirmation available.; 


uniprotID: Q12923
geneSymbol: PTPN13
reactome: R-HSA-1660499;R-HSA-9008059;
pdb: 1D5G;1Q7X;1WCH;2M0Z;2M10;3LNX;3LNY;3PDZ;5GLJ;
length: 2485
go: ENSG00000163629;
snps: rs10033029 rs749353184 rs2230600 rs12500797 rs17012064 rs989902 rs34226837
name:
Tyrosine-protein phosphatase non-receptor type 13 (EC 3.1.3.48) (Fas-associated protein-tyrosine phosphatase 1) (FAP-1) (PTP-BAS) (Protein-tyrosine phosphatase 1E) (PTP-E1) (hPTPE1) (Protein-tyrosine phosphatase PTPL1)

sequence:

opentargets:
cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; lamellipodium [GO:0030027]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; phosphatidylinositol 3-kinase regulatory subunit binding [GO:0036312]; protein tyrosine phosphatase activity [GO:0004725]; cellular response to cytokine stimulus [GO:0071345]; peptidyl-tyrosine dephosphorylation [GO:0035335]; phosphatidylinositol biosynthetic process [GO:0006661]; protein dephosphorylation [GO:0006470]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q12923-1; Sequence=Displayed; Name=2; IsoId=Q12923-2; Sequence=VSP_000496; Name=3; IsoId=Q12923-3; Sequence=VSP_000497; Name=4; IsoId=Q12923-4; Sequence=VSP_007921; Note=May be due to a competing donor splice site.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Nucleus {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Note=Colocalizes with F-actin (PubMed:10826496). Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover (PubMed:11356191). {ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:11356191}.


uniprotID: Q4JDL3
geneSymbol: PTPN20
reactome: R-HSA-9008059;
name: Tyrosine-protein phosphatase non-receptor type 20 (hPTPN20) (EC 3.1.3.48)
length: 420
go: ENSG00000204179;
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nucleoplasm [GO:0005654]; protein tyrosine phosphatase activity [GO:0004725]; cellular response to cytokine stimulus [GO:0071345]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=15;  Name=1; IsoId=Q4JDL3-1; Sequence=Displayed; Name=2; Synonyms=Variant 1; IsoId=Q4JDL3-2; Sequence=VSP_027066; Name=3; Synonyms=Variant 10; IsoId=Q4JDL3-3; Sequence=VSP_027065; Name=4; Synonyms=Variant 12; IsoId=Q4JDL3-4; Sequence=VSP_027064; Name=5; Synonyms=Variant 13; IsoId=Q4JDL3-5; Sequence=VSP_027064, VSP_027070; Name=6; Synonyms=Variant 3; IsoId=Q4JDL3-6; Sequence=VSP_027063, VSP_027071; Name=7; Synonyms=Variant 7; IsoId=Q4JDL3-7; Sequence=VSP_027072, VSP_027073; Name=8; Synonyms=Variant 4; IsoId=Q4JDL3-8; Sequence=VSP_027066, VSP_027072, VSP_027073; Name=9; Synonyms=Variant 18; IsoId=Q4JDL3-9; Sequence=VSP_027064, VSP_038003, VSP_038004; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=10; Synonyms=Variant 8; IsoId=Q4JDL3-10; Sequence=VSP_027069; Name=11; Synonyms=Variant 2; IsoId=Q4JDL3-11; Sequence=VSP_027066, VSP_027070; Name=12; Synonyms=Variant 11; IsoId=Q4JDL3-12; Sequence=VSP_027065, VSP_027072, VSP_027073; Name=13; Synonyms=Variant 9; IsoId=Q4JDL3-13; Sequence=VSP_027067, VSP_027068; Name=14; Synonyms=Variant 14; IsoId=Q4JDL3-14; Sequence=VSP_027064, VSP_027072, VSP_027073; Name=15; Synonyms=Variant 5; IsoId=Q4JDL3-15; Sequence=VSP_027066, VSP_027067, VSP_027068; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15790311}. Cytoplasm {ECO:0000269|PubMed:15790311}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15790311}. Note=Colocalizes with the microtubule-organizing center and intracellular membrane compartments.


uniprotID: Q9H3S7
geneSymbol: PTPN23
reactome: R-HSA-9008059;
pdb: 3RAU;5CRU;5CRV;5LM1;5LM2;5MJY;5MJZ;5MK0;5MK1;5MK2;5MK3;
length: 1636
go: ENSG00000076201;
snps: rs6780013 rs149563514
name:
Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)

sequence:

opentargets:
ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; protein tyrosine phosphatase activity [GO:0004725]; cellular response to cytokine stimulus [GO:0071345]; cilium assembly [GO:0060271]; early endosome to late endosome transport [GO:0045022]; endocytic recycling [GO:0032456]; negative regulation of epithelial cell migration [GO:0010633]; positive regulation of adherens junction organization [GO:1903393]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of homophilic cell adhesion [GO:1903387]; positive regulation of Wnt protein secretion [GO:0061357]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome.


uniprotID: Q9BZM1
geneSymbol: PLA2G12A
reactome: R-HSA-1482788;R-HSA-1482801;R-HSA-1482839;R-HSA-1482922;R-HSA-1482925;R-HSA-1483166;
length: 189
go: ENSG00000123739;
name:
Group XIIA secretory phospholipase A2 (GXII sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)

sequence:
MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; calcium-dependent phospholipase A2 activity [GO:0047498]; phospholipase A2 activity [GO:0004623]; phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) [GO:0102567]; phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) [GO:0102568]; arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phosphatidic acid biosynthetic process [GO:0006654]; phosphatidylcholine acyl-chain remodeling [GO:0036151]; phosphatidylethanolamine acyl-chain remodeling [GO:0036152]; phosphatidylglycerol acyl-chain remodeling [GO:0036148]; phosphatidylinositol acyl-chain remodeling [GO:0036149]; phosphatidylserine acyl-chain remodeling [GO:0036150]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12522102}. Cytoplasm {ECO:0000269|PubMed:12522102}.


uniprotID: Q9BX93
geneSymbol: PLA2G12B
length: 195
go: ENSG00000138308;
location: SUBCELLULAR LOCATION: Secreted.
name:
Group XIIB secretory phospholipase A2-like protein (Group XIII secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB)

sequence:
MKLASGFLVLWLSLGGGLAQSDTSPDTEESYSDWGLRHLRGSFESVNSYFDSFLELLGGKNGVCQYRCRYGKAPMPRPGYKPQEPNGCGSYFLGLKVPESMDLGIPAMTKCCNQLDVCYDTCGANKYRCDAKFRWCLHSICSDLKRSLGFVSKVEAACDSLVDTVFNTVWTLGCRPFMNSQRAACICAEEEKEEL

opentargets:
extracellular region [GO:0005576]; calcium ion binding [GO:0005509]; phospholipase A2 activity [GO:0004623]; arachidonic acid secretion [GO:0050482]; lipid catabolic process [GO:0016042]; phospholipid metabolic process [GO:0006644]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BX93-1; Sequence=Displayed; Name=2; IsoId=Q9BX93-2; Sequence=VSP_054398; 


uniprotID: P29074
geneSymbol: PTPN4
reactome: R-HSA-166016;R-HSA-9008059;
pdb: 2CS5;2I75;2VPH;3NFK;3NFL;5EYZ;5EZ0;
length: 926
go: ENSG00000088179;
drug: DB00630;
snps: rs3189128
name:
Tyrosine-protein phosphatase non-receptor type 4 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG1) (MEG) (PTPase-MEG1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytoskeleton [GO:0005856]; nucleoplasm [GO:0005654]; cytoskeletal protein binding [GO:0008092]; non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]; cellular response to cytokine stimulus [GO:0071345]; protein dephosphorylation [GO:0006470]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.


uniprotID: Q8N0Y7
geneSymbol: PGAM4
name: Probable phosphoglycerate mutase 4 (EC 5.4.2.11) (EC 5.4.2.4)
length: 254
go: ENSG00000226784;
snps: rs782408548 rs5959129
sequence:

opentargets:
extracellular exosome [GO:0070062]; sperm principal piece [GO:0097228]; bisphosphoglycerate mutase activity [GO:0004082]; hydrolase activity [GO:0016787]; phosphoglycerate mutase activity [GO:0004619]; glycolytic process [GO:0006096]; positive regulation of flagellated sperm motility [GO:1902093]


uniprotID: P16112
geneSymbol: ACAN
reactome: R-HSA-1474228;R-HSA-2022854;R-HSA-2022857;R-HSA-3000178;R-HSA-3656225;R-HSA-3656243;R-HSA-3656244;
pdb: 4MD4;
length: 2530
go: ENSG00000157766;
drug: DB02255;
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
name:
Aggrecan core protein (Cartilage-specific proteoglycan core protein) (CSPCP) (Chondroitin sulfate proteoglycan core protein 1) (Chondroitin sulfate proteoglycan 1) [Cleaved into: Aggrecan core protein 2]

sequence:

opentargets:
basement membrane [GO:0005604]; collagen-containing extracellular matrix [GO:0062023]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; lysosomal lumen [GO:0043202]; perisynaptic extracellular matrix [GO:0098966]; carbohydrate binding [GO:0030246]; extracellular matrix structural constituent [GO:0005201]; extracellular matrix structural constituent conferring compression resistance [GO:0030021]; hyaluronic acid binding [GO:0005540]; metal ion binding [GO:0046872]; cartilage condensation [GO:0001502]; cell adhesion [GO:0007155]; central nervous system development [GO:0007417]; chondrocyte development [GO:0002063]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; heart development [GO:0007507]; keratan sulfate biosynthetic process [GO:0018146]; keratan sulfate catabolic process [GO:0042340]; proteoglycan biosynthetic process [GO:0030166]; proteolysis [GO:0006508]; skeletal system development [GO:0001501]

snps:
rs16942318 rs34949187 rs3743398 rs35430524 rs938608 rs938609 rs373544100 rs12899191 rs2882676 rs4932439 rs35061438 rs1042630 rs34153007 rs3817428 rs121913568 rs779794758 rs1126823 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P16112-1; Sequence=Displayed; Name=2; IsoId=P16112-2; Sequence=VSP_003074; Name=3; IsoId=P16112-3; Sequence=VSP_003074, VSP_003075; 


uniprotID: Q96DM1
geneSymbol: PGBD4
name: PiggyBac transposable element-derived protein 4
length: 585
go: ENSG00000182405;
sequence:


uniprotID: Q8N414
geneSymbol: PGBD5
length: 524
go: ENSG00000177614;
opentargets: nucleus [GO:0005634]; endonuclease activity [GO:0004519]; transposition [GO:0032196]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24180413}.
name:
PiggyBac transposable element-derived protein 5 (EC 3.1.-.-) (PiggyBac domain-related protein 5) (PiggyBac transposase 5)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N414-1; Sequence=Displayed; Name=2; IsoId=Q8N414-2; Sequence=VSP_059131; Note=No experimental confirmation available. {ECO:0000305|PubMed:15489334}; 


uniprotID: Q15198
geneSymbol: PDGFRL
length: 375
go: ENSG00000104213;
snps: rs137853148
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
name:
Platelet-derived growth factor receptor-like protein (PDGFR-like protein) (PDGF receptor beta-like tumor suppressor)

sequence:

opentargets:
extracellular region [GO:0005576]; platelet activating factor receptor activity [GO:0004992]; platelet-derived growth factor beta-receptor activity [GO:0005019]


uniprotID: A2A3K4
geneSymbol: PTPDC1
name: Protein tyrosine phosphatase domain-containing protein 1 (EC 3.1.3.-)
length: 754
go: ENSG00000158079;
snps: rs16909677
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cilium assembly [GO:0060271]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A2A3K4-1; Sequence=Displayed; Name=2; IsoId=A2A3K4-2; Sequence=VSP_029736; 


uniprotID: Q8WUK0
geneSymbol: PTPMT1
reactome: R-HSA-1483148;
length: 201
go: ENSG00000110536;
name:
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC 3.1.3.27) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase) (Protein-tyrosine phosphatase mitochondrial 1) (EC 3.1.3.16) (EC 3.1.3.48)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; nucleus [GO:0005634]; phosphatidylglycerophosphatase activity [GO:0008962]; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [GO:0004439]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cardiolipin biosynthetic process [GO:0032049]; regulation of intrinsic apoptotic signaling pathway [GO:2001242]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8WUK0-1; Sequence=Displayed; Name=2; IsoId=Q8WUK0-2; Sequence=VSP_015009; Name=3; IsoId=Q8WUK0-3; Sequence=VSP_045030, VSP_045031; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P0C089}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C089}; Matrix side {ECO:0000250|UniProtKB:P0C089}.


uniprotID: P23467
geneSymbol: PTPRB
reactome: R-HSA-6798695;
pdb: 2AHS;2H02;2H03;2H04;2HC1;2HC2;2I3R;2I3U;2I4E;2I4G;2I4H;2I5X;
length: 1997
go: ENSG00000127329;
drug: DB08678;DB06989;
snps: rs2252784 rs2465811 rs36027530 rs2165627 rs2304821 rs34902691 rs17226367
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
Receptor-type tyrosine-protein phosphatase beta (Protein-tyrosine phosphatase beta) (R-PTP-beta) (EC 3.1.3.48) (Vascular endothelial protein tyrosine phosphatase) (VE-PTP)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; angiogenesis [GO:0001525]; dephosphorylation [GO:0016311]; neutrophil degranulation [GO:0043312]; phosphate-containing compound metabolic process [GO:0006796]; protein dephosphorylation [GO:0006470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P23467-1; Sequence=Displayed; Name=2; IsoId=P23467-2; Sequence=VSP_038521; Name=3; IsoId=P23467-3; Sequence=VSP_040484; Name=4; IsoId=P23467-4; Sequence=VSP_053944; 


uniprotID: Q9HD43
geneSymbol: PTPRH
length: 1115
go: ENSG00000080031;
snps: rs55870162 rs45535035 rs2288515 rs16986309 rs2288523 rs890870 rs36092369 rs2288419
name:
Receptor-type tyrosine-protein phosphatase H (R-PTP-H) (EC 3.1.3.48) (Stomach cancer-associated protein tyrosine phosphatase 1) (SAP-1) (Transmembrane-type protein-tyrosine phosphatase type H)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; microvillus membrane [GO:0031528]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; apoptotic process [GO:0006915]; protein dephosphorylation [GO:0006470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9HD43-1; Sequence=Displayed; Name=2; IsoId=Q9HD43-2; Sequence=VSP_031318; Name=3; IsoId=Q9HD43-3; Sequence=VSP_054222; 

location:
SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:E9Q0N2}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12879010}. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250|UniProtKB:E9Q0N2}.


uniprotID: P28827
geneSymbol: PTPRM
pdb: 1RPM;2C9A;2V5Y;
length: 1452
go: ENSG00000173482;
snps: rs35224276
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Receptor-type tyrosine-protein phosphatase mu (Protein-tyrosine phosphatase mu) (R-PTP-mu) (EC 3.1.3.48)

sequence:

opentargets:
cell-cell adherens junction [GO:0005913]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; lamellipodium [GO:0030027]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; protein tyrosine phosphatase activity [GO:0004725]; transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; negative regulation of angiogenesis [GO:0016525]; negative regulation of endothelial cell migration [GO:0010596]; negative regulation of endothelial cell proliferation [GO:0001937]; neuron projection development [GO:0031175]; positive regulation of blood vessel diameter [GO:0097755]; protein dephosphorylation [GO:0006470]; response to drug [GO:0042493]; retina layer formation [GO:0010842]; retinal ganglion cell axon guidance [GO:0031290]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P28827-1; Sequence=Displayed; Name=2; IsoId=P28827-2; Sequence=VSP_046677; 


uniprotID: P07205
geneSymbol: PGK2
reactome: R-HSA-70171;R-HSA-70263;
name: Phosphoglycerate kinase 2 (EC 2.7.2.3) (Phosphoglycerate kinase, testis specific)
length: 417
go: ENSG00000170950;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; sperm fibrous sheath [GO:0035686]; ADP binding [GO:0043531]; ATP binding [GO:0005524]; phosphoglycerate kinase activity [GO:0004618]; chemical synaptic transmission [GO:0007268]; flagellated sperm motility [GO:0030317]; gluconeogenesis [GO:0006094]; glycolytic process [GO:0006096]; muscle cell cellular homeostasis [GO:0046716]; myoblast fusion [GO:0007520]; phosphorylation [GO:0016310]; somatic muscle development [GO:0007525]


uniprotID: Q9NZH5
geneSymbol: PTTG2
name: Securin-2 (Pituitary tumor-transforming gene 2 protein)
length: 202
go: ENSG00000250254;
snps: rs6811863
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; SH3 domain binding [GO:0017124]; chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143]; negative regulation of mitotic sister chromatid separation [GO:2000816]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NZH5-1; Sequence=Displayed; Name=2; IsoId=Q9NZH5-2; Sequence=VSP_031444; 


uniprotID: Q9NZH4
geneSymbol: PTTG3P
name: Putative pituitary tumor-transforming gene 3 protein (hPTTG3) (Securin-3) (rcPTTG1)
length: 202
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; SH3 domain binding [GO:0017124]; chromosome organization [GO:0051276]; homologous chromosome segregation [GO:0045143]; negative regulation of mitotic sister chromatid separation [GO:2000816]


uniprotID: P53801
geneSymbol: PTTG1IP
length: 180
go: ENSG00000183255;
name:
Pituitary tumor-transforming gene 1 protein-interacting protein (Pituitary tumor-transforming gene protein-binding factor) (PBF) (PTTG-binding factor)

sequence:
MAPGVARGPTPYWRLRLGGAALLLLLIPVAAAQEPPGAACSQNTNKTCEECLKNVSCLWCNTNKACLDYPVTSVLPPASLCKLSSARWGVCWVNFEALIITMSVVGGTLLLGIAICCCCCCRRKRSRKPDRSEEKAMREREERRIRQEERRAEMKTRHDEIRKKYGLFKEENPYARFENN

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; p53 binding [GO:0002039]; negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902254]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of protein ubiquitination [GO:0031398]; protein import into nucleus [GO:0006606]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10781616}. Nucleus {ECO:0000269|PubMed:10781616}. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus.


uniprotID: Q9H0N5
geneSymbol: PCBD2
pdb: 4C45;
length: 130
go: ENSG00000132570;
name:
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)

sequence:
MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDAIYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAASV

opentargets:
nucleus [GO:0005634]; 4-alpha-hydroxytetrahydrobiopterin dehydratase activity [GO:0008124]; phenylalanine 4-monooxygenase activity [GO:0004505]; positive regulation of transcription, DNA-templated [GO:0045893]; protein heterooligomerization [GO:0051291]; protein homotetramerization [GO:0051289]; tetrahydrobiopterin biosynthetic process [GO:0006729]


uniprotID: Q9UMS5
geneSymbol: PHTF1
name: Putative homeodomain transcription factor 1
length: 762
go: ENSG00000116793;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
cis-Golgi network [GO:0005801]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UMS5-1; Sequence=Displayed; Name=2; IsoId=Q9UMS5-2; Sequence=VSP_002144, VSP_002145; Note=No experimental confirmation available.; 


uniprotID: O14813
geneSymbol: PHOX2A
length: 284
go: ENSG00000165462;
snps: rs104894269
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
name:
Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A)

sequence:

opentargets:
nuclear chromatin [GO:0000790]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; dopaminergic neuron differentiation [GO:0071542]; locus ceruleus development [GO:0021703]; midbrain development [GO:0030901]; noradrenergic neuron differentiation [GO:0003357]; oculomotor nerve formation [GO:0021623]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of respiratory gaseous exchange [GO:0043576]; somatic motor neuron differentiation [GO:0021523]; sympathetic nervous system development [GO:0048485]; trochlear nerve formation [GO:0021642]


uniprotID: Q99570
geneSymbol: PIK3R4
reactome: R-HSA-109704;R-HSA-1632852;R-HSA-1660514;R-HSA-1660516;R-HSA-1660517;R-HSA-168138;R-HSA-5668599;
length: 1358
go: ENSG00000196455;
snps: rs55951445 rs56295394 rs34797184 rs34663155 rs34633532 rs56369596 rs181132426 rs56160735
name:
Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)

sequence:

opentargets:
autophagosome [GO:0005776]; axoneme [GO:0005930]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; late endosome [GO:0005770]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nuclear pore [GO:0005643]; nucleus-vacuole junction [GO:0071561]; phagocytic vesicle membrane [GO:0030670]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; autophagy of peroxisome [GO:0030242]; cellular response to glucose starvation [GO:0042149]; late endosome to vacuole transport [GO:0045324]; macroautophagy [GO:0016236]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; protein phosphorylation [GO:0006468]; protein targeting to vacuole [GO:0006623]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; toll-like receptor 9 signaling pathway [GO:0034162]

location:
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:14617358}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes. Localizes also to discrete punctae along the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8VD65, ECO:0000305}.


uniprotID: Q8WYR1
geneSymbol: PIK3R5
reactome: R-HSA-114604;R-HSA-1660499;R-HSA-392451;
length: 880
go: ENSG00000141506;
snps: rs371789171 rs61761068
name:
Phosphoinositide 3-kinase regulatory subunit 5 (PI3-kinase regulatory subunit 5) (PI3-kinase p101 subunit) (Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit) (PtdIns-3-kinase regulatory subunit) (Protein FOAP-2) (PtdIns-3-kinase p101) (p101-PI3K)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; G-protein beta/gamma-subunit complex binding [GO:0031683]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphatidylinositol 3-kinase signaling [GO:0014065]; platelet activation [GO:0030168]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein kinase B signaling [GO:0051897]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WYR1-1; Sequence=Displayed; Name=2; IsoId=Q8WYR1-2; Sequence=VSP_016388; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O02696}. Cytoplasm {ECO:0000250|UniProtKB:O02696}. Cell membrane {ECO:0000250|UniProtKB:O02696}; Peripheral membrane protein {ECO:0000250|UniProtKB:O02696}. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250|UniProtKB:O02696}.


uniprotID: Q8IYJ0
geneSymbol: PIANP
reactome: R-HSA-198933;
length: 282
go: ENSG00000139200;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
name:
PILR alpha-associated neural protein (PILR-associating neural protein) (Paired immunoglobin-like type 2 receptor-associating neural protein)

sequence:

opentargets:
adherens junction [GO:0005912]; basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; regulation of immune response [GO:0050776]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IYJ0-1; Sequence=Displayed; Name=2; IsoId=Q8IYJ0-2; Sequence=VSP_024939; 


uniprotID: O75925
geneSymbol: PIAS1
pdb: 1V66;
length: 651
go: ENSG00000033800;
reactome:
R-HSA-3108214;R-HSA-3232118;R-HSA-3232142;R-HSA-3899300;R-HSA-4090294;R-HSA-4551638;R-HSA-5696395;R-HSA-877312;

name:
E3 SUMO-protein ligase PIAS1 (EC 2.3.2.-) (DEAD/H box-binding protein 1) (E3 SUMO-protein transferase PIAS1) (Gu-binding protein) (GBP) (Protein inhibitor of activated STAT protein 1) (RNA helicase II-binding protein)

sequence:

opentargets:
nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; androgen receptor binding [GO:0050681]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; SUMO ligase activity [GO:0061665]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]; androgen receptor signaling pathway [GO:0030521]; fat cell differentiation [GO:0045444]; G1/S transition of mitotic cell cycle [GO:0000082]; JAK-STAT cascade [GO:0007259]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein sumoylation [GO:0033235]; positive regulation of smooth muscle cell differentiation [GO:0051152]; positive regulation of transcription, DNA-templated [GO:0045893]; protein sumoylation [GO:0016925]; protein-DNA complex assembly [GO:0065004]; regulation of cell proliferation [GO:0042127]; regulation of interferon-gamma-mediated signaling pathway [GO:0060334]; spermatogenesis [GO:0007283]; visual learning [GO:0008542]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O75925-1; Sequence=Displayed; Name=2; IsoId=O75925-2; Sequence=VSP_056219; Note=No experimental confirmation available.; Name=3; IsoId=O75925-3; Sequence=VSP_057195, VSP_057196; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12393906, ECO:0000269|PubMed:19136629, ECO:0000269|PubMed:9177271}. Nucleus, PML body {ECO:0000250}. Note=Interaction with CSRP2 may induce a partial redistribution along the cytoskeleton.


uniprotID: A4QPH2
geneSymbol: PI4KAP2
name: Putative phosphatidylinositol 4-kinase alpha-like protein P2
length: 592
snps: rs2930770
sequence:

opentargets:
cytoplasm [GO:0005737]; membrane [GO:0016020]; plasma membrane [GO:0005886]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A4QPH2-1; Sequence=Displayed; Name=2; IsoId=A4QPH2-2; Sequence=VSP_031848, VSP_031849, VSP_031850; Note=No experimental confirmation available.; Name=3; IsoId=A4QPH2-4; Sequence=VSP_031848, VSP_057629, VSP_057630; Note=No experimental confirmation available.; 


uniprotID: Q9H5I5
geneSymbol: PIEZO2
name: Piezo-type mechanosensitive ion channel component 2 (Protein FAM38B)
length: 2752
go: ENSG00000154864;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cation channel activity [GO:0005261]; mechanosensitive ion channel activity [GO:0008381]; cation transport [GO:0006812]; cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; detection of mechanical stimulus involved in sensory perception [GO:0050974]; regulation of membrane potential [GO:0042391]; response to mechanical stimulus [GO:0009612]

snps:
rs587777453 rs587777076 rs7234309 rs886039823 rs3748428 rs587777451 rs587777450 rs587777452 rs587777452 rs587777454 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9H5I5-1; Sequence=Displayed; Name=2; IsoId=Q9H5I5-2; Sequence=VSP_040472; Note=No experimental confirmation available.; Name=3; IsoId=Q9H5I5-3; Sequence=VSP_040471; Note=No experimental confirmation available.; Name=4; IsoId=Q9H5I5-4; Sequence=VSP_040630; Note=No experimental confirmation available.; 


uniprotID: Q14442
geneSymbol: PIGH
reactome: R-HSA-162710;
length: 188
go: ENSG00000100564;
snps: rs776038451
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class H protein) (PIG-H)

sequence:
MEDERSFSDICGGRLALQRRYYSPSCREFCLSCPRLSLRSLTAVTCTVWLAAYGLFTLCENSMILSAAIFITLLGLLGYLHFVKIDQETLLIIDSLGIQMTSSYASGKESTTFIEMGKVKDIVINEAIYMQKVIYYLCILLKDPVEPHGISQVVPVFQSAKPRLDCLIEVYRSCQEILAHQKATSTSP

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; catalytic activity [GO:0003824]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; cellular protein modification process [GO:0006464]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]


uniprotID: Q9Y2B2
geneSymbol: PIGL
reactome: R-HSA-162710;
length: 252
go: ENSG00000108474;
snps: rs145303331
name:
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; N-acetylglucosaminylphosphatidylinositol deacetylase activity [GO:0000225]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2B2-1; Sequence=Displayed; Name=2; IsoId=Q9Y2B2-2; Sequence=VSP_056886; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.


uniprotID: Q9NUD9
geneSymbol: PIGV
reactome: R-HSA-162710;
length: 493
go: ENSG00000060642;
snps: rs267606952 rs139073416 rs139073416 rs267606951
name:
GPI mannosyltransferase 2 (EC 2.4.1.-) (GPI mannosyltransferase II) (GPI-MT-II) (Phosphatidylinositol-glycan biosynthesis class V protein) (PIG-V)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; mannosyltransferase complex [GO:0031501]; dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity [GO:0004584]; glycolipid mannosyltransferase activity [GO:0004376]; mannosyltransferase activity [GO:0000030]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15623507}; Multi-pass membrane protein {ECO:0000269|PubMed:15623507}.


uniprotID: Q8TEQ8
geneSymbol: PIGO
reactome: R-HSA-162710;
length: 1089
go: ENSG00000165282;
snps: rs757441073 rs779525065 rs1214104267 rs909488930 rs142164373
name:
GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mannose-ethanolamine phosphotransferase activity [GO:0051377]; GPI anchor biosynthetic process [GO:0006506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q8TEQ8-1; Sequence=Displayed; Name=2; IsoId=Q8TEQ8-2; Sequence=VSP_003944; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9JJI6}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: P11309
geneSymbol: PIM1
reactome: R-HSA-6785807;
name: Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)
length: 313
go: ENSG00000137193;
drug: DB03650;DB02656;DB07151;DB00131;DB04715;DB04395;DB04522;DB04216;DB03777;DB02010;
pdb:
1XQZ;1XR1;1XWS;1YHS;1YI3;1YI4;1YWV;1YXS;1YXT;1YXU;1YXV;1YXX;2BIK;2BIL;2BZH;2BZI;2BZJ;2BZK;2C3I;2J2I;2O3P;2O63;2O64;2O65;2OBJ;2OI4;2XIX;2XIY;2XIZ;2XJ0;2XJ1;2XJ2;3A99;3BGP;3BGQ;3BGZ;3BWF;3C4E;3CXW;3CY2;3CY3;3DCV;3F2A;3JPV;3JXW;3JY0;3JYA;3MA3;3QF9;3R00;3R01;3R02;3R04;3T9I;3UIX;3UMW;3UMX;3VBQ;3VBT;3VBV;3VBW;3VBX;3VBY;3VC4;3WE8;4A7C;4ALU;4ALV;4ALW;4AS0;4BZN;4BZO;4DTK;4ENX;4ENY;4GW8;4I41;4IAA;4JX3;4JX7;4K0Y;4K18;4K1B;4LL5;4LM5;4LMU;4MBI;4MBL;4MED;4MTA;4N6Y;4N6Z;4N70;4RBL;4RC2;4RC3;4RC4;4RPV;4TY1;4WRS;4WSY;4WT6;4XH6;4XHK;5C1Q;5DGZ;5DHJ;5DIA;5DWR;5EOL;5IIS;5IPJ;5KCX;5KGD;5KGE;5KGG;5KGI;5KGK;5KZI;5MZL;5N4N;5N4O;5N4R;5N4U;5N4V;5N4X;5N4Y;5N4Z;5N50;5N51;5N52;5N5L;5N5M;5NDT;5O11;5O12;5O13;5TEL;5TEX;5TOE;5TUR;5V80;5V82;5VUA;5VUB;5VUC;6AYD;6BSK;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; manganese ion binding [GO:0030145]; protein serine/threonine kinase activity [GO:0004674]; ribosomal small subunit binding [GO:0043024]; transcription factor binding [GO:0008134]; apoptotic process [GO:0006915]; cell cycle [GO:0007049]; cell proliferation [GO:0008283]; cytokine-mediated signaling pathway [GO:0019221]; hyaluronan metabolic process [GO:0030212]; multicellular organism development [GO:0007275]; negative regulation of apoptotic process [GO:0043066]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cardioblast proliferation [GO:1905062]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; vitamin D receptor signaling pathway [GO:0070561]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=2;  Name=1; IsoId=P11309-1; Sequence=Displayed; Name=2; IsoId=P11309-2; Sequence=VSP_059829; Note=Initiates from CTG codon. {ECO:0000269|PubMed:16186805, ECO:0000269|PubMed:1825810}; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane.


uniprotID: P22061
geneSymbol: PCMT1
reactome: R-HSA-5676934;
pdb: 1I1N;1KR5;
length: 227
drug: DB01752;
snps: rs4816
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PIMT) (EC 2.1.1.77) (L-isoaspartyl protein carboxyl methyltransferase) (Protein L-isoaspartyl/D-aspartyl methyltransferase) (Protein-beta-aspartate methyltransferase)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular vesicle [GO:1903561]; cadherin binding [GO:0045296]; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity [GO:0004719]; protein methylation [GO:0006479]; protein repair [GO:0030091]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P22061-1; Sequence=Displayed; Name=2; IsoId=P22061-2; Sequence=VSP_004716; 


uniprotID: Q13526
geneSymbol: PIN1
reactome: R-HSA-1169408;R-HSA-6804756;R-HSA-6811555;R-HSA-936440;
length: 163
go: ENSG00000127445;
drug: DB01766;
pdb:
1F8A;1I6C;1I8G;1I8H;1NMV;1NMW;1PIN;1ZCN;2F21;2ITK;2KBU;2KCF;2LB3;2M8I;2M8J;2M9E;2M9F;2M9I;2M9J;2N1O;2Q5A;2RUC;2RUD;2RUQ;2RUR;2XP3;2XP4;2XP5;2XP6;2XP7;2XP8;2XP9;2XPA;2XPB;2ZQS;2ZQT;2ZQU;2ZQV;2ZR4;2ZR5;2ZR6;3I6C;3IK8;3IKD;3IKG;3JYJ;3KAB;3KAC;3KAD;3KAF;3KAG;3KAH;3KAI;3KCE;3NTP;3ODK;3OOB;3TC5;3TCZ;3TDB;3WH0;4GWT;4GWV;4QIB;4TNS;4TYO;4U84;4U85;4U86;5B3W;5B3X;5B3Y;5B3Z;5BMY;5GPH;5UY9;5VTI;5VTJ;5VTK;

name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1)

sequence:
MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; midbody [GO:0030496]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic cytosol [GO:0099524]; beta-catenin binding [GO:0008013]; GTPase activating protein binding [GO:0032794]; mitogen-activated protein kinase kinase binding [GO:0031434]; motor activity [GO:0003774]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]; phosphoprotein binding [GO:0051219]; phosphoserine residue binding [GO:0050815]; phosphothreonine residue binding [GO:0050816]; cell cycle [GO:0007049]; negative regulation of cell motility [GO:2000146]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of type I interferon production [GO:0032480]; neuron differentiation [GO:0030182]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cell growth involved in cardiac muscle cell development [GO:0061051]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of protein binding [GO:0032092]; positive regulation of protein dephosphorylation [GO:0035307]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein peptidyl-prolyl isomerization [GO:0000413]; protein stabilization [GO:0050821]; regulation of cytokinesis [GO:0032465]; regulation of gene expression [GO:0010468]; regulation of mitotic nuclear division [GO:0007088]; regulation of pathway-restricted SMAD protein phosphorylation [GO:0060393]; regulation of protein localization to nucleus [GO:1900180]; regulation of protein phosphorylation [GO:0001932]; regulation of signal transduction by p53 class mediator [GO:1901796]; synapse organization [GO:0050808]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16476580, ECO:0000269|PubMed:23623683}. Nucleus speckle {ECO:0000269|PubMed:21497122}. Cytoplasm {ECO:0000269|PubMed:21497122}. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269|PubMed:16476580}.


uniprotID: A2A3N6
geneSymbol: PIPSL
name: Putative PIP5K1A and PSMD4-like protein (PIP5K1A-PSMD4)
length: 862
opentargets: cytoplasm [GO:0005737]; phosphatidylinositol phosphate kinase activity [GO:0016307]
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17623810}.
sequence:


uniprotID: A6NC86
geneSymbol: PINLYP
name: phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein
length: 204
go: ENSG00000234465;
opentargets: extracellular region [GO:0005576]; phospholipase inhibitor activity [GO:0004859]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=A6NC86-1; Sequence=Displayed; Name=2; IsoId=A6NC86-2; Sequence=VSP_044189; Note=No experimental confirmation available.; Name=3; IsoId=A6NC86-3; Sequence=VSP_044189, VSP_044190; Note=No experimental confirmation available. {ECO:0000305}; Name=4; IsoId=A6NC86-4; Sequence=VSP_044188; Note=No experimental confirmation available.; 


uniprotID: O15428
geneSymbol: PIN1P1
name: Putative PIN1-like protein (Peptidylprolyl cis-trans isomerase NIMA-interacting 1 pseudogene 1)
length: 100
sequence:
MADEEKLPPGWEKRMSRPSGRGYYFNHITNPSQWERPSGNSSSGGKIWQGEPARVRRSHLLVKPVKAALDLAAGNHPDQGGGPGADQRLHPEDQGRREGL

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; peptidyl-prolyl cis-trans isomerase activity [GO:0003755]


uniprotID: O00625
geneSymbol: PIR
reactome: R-HSA-8935690;
pdb: 1J1L;3ACL;4ERO;4EWA;4EWD;4EWE;4GUL;4HLT;5JCT;
name: Pirin (EC 1.13.11.24) (Probable quercetin 2,3-dioxygenase PIR) (Probable quercetinase)
length: 290
go: ENSG00000087842;
snps: rs34104000
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; quercetin 2,3-dioxygenase activity [GO:0008127]; transcription coregulator activity [GO:0003712]; digestion [GO:0007586]; monocyte differentiation [GO:0030224]; transcription by RNA polymerase II [GO:0006366]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}. Cytoplasm {ECO:0000269|PubMed:20089166}. Note=Predominantly localized in dot-like subnuclear structures. Cytoplasmic localization of PIR seems to positively correlate with melanoma progression. {ECO:0000269|PubMed:20089166, ECO:0000269|PubMed:9079676}.


uniprotID: O75364
geneSymbol: PITX3
name: Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)
length: 302
go: ENSG00000107859;
snps: rs104894175
sequence:

opentargets:
neuronal cell body [GO:0043025]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; sequence-specific DNA binding [GO:0043565]; aging [GO:0007568]; anatomical structure morphogenesis [GO:0009653]; animal organ morphogenesis [GO:0009887]; cellular response to glial cell derived neurotrophic factor [GO:1990792]; dopaminergic neuron differentiation [GO:0071542]; lens development in camera-type eye [GO:0002088]; lens fiber cell differentiation [GO:0070306]; lens morphogenesis in camera-type eye [GO:0002089]; locomotory behavior [GO:0007626]; midbrain development [GO:0030901]; negative regulation of gliogenesis [GO:0014014]; neuron development [GO:0048666]; positive regulation of cell proliferation in midbrain [GO:1904935]; positive regulation of neuron apoptotic process [GO:0043525]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription, DNA-templated [GO:0006355]; response to cocaine [GO:0042220]; response to immobilization stress [GO:0035902]; response to methamphetamine hydrochloride [GO:1904313]; response to morphine [GO:0043278]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.


uniprotID: O00562
geneSymbol: PITPNM1
reactome: R-HSA-1483226;
length: 1244
go: ENSG00000110697;
name:
Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)

sequence:

opentargets:
cell body [GO:0044297]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; Golgi cisterna membrane [GO:0032580]; lipid droplet [GO:0005811]; membrane [GO:0016020]; microtubule organizing center [GO:0005815]; midbody [GO:0030496]; calcium ion binding [GO:0005509]; phosphatidic acid binding [GO:0070300]; phosphatidylcholine binding [GO:0031210]; phosphatidylcholine transporter activity [GO:0008525]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol transporter activity [GO:0008526]; receptor tyrosine kinase binding [GO:0030971]; brain development [GO:0007420]; lipid metabolic process [GO:0006629]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid transport [GO:0015914]; phototransduction [GO:0007602]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00562-1; Sequence=Displayed; Name=2; IsoId=O00562-2; Sequence=VSP_021157; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:12225667}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12225667}; Peripheral membrane protein. Lipid droplet {ECO:0000269|PubMed:12225667}. Cleavage furrow {ECO:0000269|PubMed:15125835}. Midbody {ECO:0000269|PubMed:15125835}. Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667). Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835). {ECO:0000269|PubMed:12225667, ECO:0000269|PubMed:15125835}.


uniprotID: P78337
geneSymbol: PITX1
length: 314
go: ENSG00000069011;
snps: rs121909109 rs479632
location: SUBCELLULAR LOCATION: Nucleus.
name:
Pituitary homeobox 1 (Hindlimb-expressed homeobox protein backfoot) (Homeobox protein PITX1) (Paired-like homeodomain transcription factor 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; sequence-specific DNA binding [GO:0043565]; anatomical structure morphogenesis [GO:0009653]; branchiomeric skeletal muscle development [GO:0014707]; cartilage development [GO:0051216]; embryonic hindlimb morphogenesis [GO:0035116]; myoblast fate commitment [GO:0048625]; negative regulation of transcription, DNA-templated [GO:0045892]; pituitary gland development [GO:0021983]; skeletal system development [GO:0001501]


uniprotID: Q8TDX9
geneSymbol: PKD1L1
name: Polycystic kidney disease protein 1-like 1 (PC1-like 1 protein) (Polycystin-1L1)
length: 2849
go: ENSG00000158683;
sequence:

opentargets:
calcium channel complex [GO:0034704]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; membrane [GO:0016020]; non-motile cilium [GO:0097730]; calcium channel activity [GO:0005262]; cell-cell adhesion [GO:0098609]; detection of mechanical stimulus [GO:0050982]; detection of nodal flow [GO:0003127]; left/right axis specification [GO:0070986]

snps:
rs2686817 rs17131915 rs11972142 rs56100904 rs141681038 rs10274334 rs1470859 rs886037834 rs17131834 rs2290386 rs59848490 rs13231277 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TDX9-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8TDX9-2; Sequence=VSP_013215, VSP_013216; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:24336289}; Multi-pass membrane protein {ECO:0000269|PubMed:24336289}.


uniprotID: O00329
geneSymbol: PIK3CD
pdb: 5DXU;5M6U;5T8F;5UBT;5VLR;
length: 1044
go: ENSG00000171608;
drug: DB06831;DB00201;DB05241;
snps: rs397518423
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22020336}.
reactome:
R-HSA-1257604;R-HSA-1660499;R-HSA-2219530;R-HSA-512988;R-HSA-6811558;R-HSA-8853659;R-HSA-912526;R-HSA-912631;R-HSA-983695;

name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PI3-kinase subunit delta) (PI3K-delta) (PI3Kdelta) (PtdIns-3-kinase subunit delta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta) (PtdIns-3-kinase subunit p110-delta) (p110delta)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mast cell granule [GO:0042629]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; phosphatidylinositol 3-kinase activity [GO:0035004]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; adaptive immune response [GO:0002250]; axon guidance [GO:0007411]; B cell activation [GO:0042113]; B cell chemotaxis [GO:0035754]; B cell receptor signaling pathway [GO:0050853]; cell migration [GO:0016477]; cytokine production [GO:0001816]; cytokine-mediated signaling pathway [GO:0019221]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell chemotaxis [GO:0002551]; mast cell degranulation [GO:0043303]; mast cell differentiation [GO:0060374]; natural killer cell activation [GO:0030101]; natural killer cell chemotaxis [GO:0035747]; natural killer cell differentiation [GO:0001779]; negative regulation of gene expression [GO:0010629]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; positive regulation of cell migration [GO:0030335]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of protein kinase B signaling [GO:0051897]; protein phosphorylation [GO:0006468]; respiratory burst involved in defense response [GO:0002679]; signal transduction [GO:0007165]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell differentiation [GO:0030217]; T cell receptor signaling pathway [GO:0050852]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=p110-delta; IsoId=O00329-1; Sequence=Displayed; Name=2; Synonyms=p37-delta; IsoId=O00329-2; Sequence=VSP_044409, VSP_044410; 


uniprotID: P48736
geneSymbol: PIK3CG
reactome: R-HSA-114604;R-HSA-1660499;R-HSA-392451;
length: 1102
go: ENSG00000105851;
drug: DB06831;DB02656;DB02375;DB06836;DB04216;DB02010;DB05241;
pdb:
1E8Y;1E8Z;1HE8;2A4Z;2A5U;2CHW;2CHX;2CHZ;2V4L;3APC;3APD;3APF;3CSF;3CST;3DBS;3DPD;3ENE;3IBE;3L08;3L13;3L16;3L17;3L54;3LJ3;3MJW;3ML8;3ML9;3NZS;3NZU;3OAW;3P2B;3PRE;3PRZ;3PS6;3QAQ;3QAR;3QJZ;3QK0;3R7Q;3R7R;3S2A;3SD5;3T8M;3TJP;3TL5;3ZVV;3ZW3;4ANU;4ANV;4ANW;4ANX;4AOF;4DK5;4EZJ;4EZK;4EZL;4F1S;4FA6;4FAD;4FHJ;4FHK;4FJY;4FJZ;4FLH;4FUL;4G11;4GB9;4HLE;4HVB;4J6I;4KZ0;4KZC;4PS3;4PS7;4PS8;4URK;4WWN;4WWO;4WWP;4XX5;4XZ4;5EDS;5G2N;5G55;5JHA;5JHB;5KAE;5OQ4;5T23;6AUD;6C1S;6GQ7;

name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mast cell granule [GO:0042629]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; ephrin receptor binding [GO:0046875]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; phosphatidylinositol 3-kinase activity [GO:0035004]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; adaptive immune response [GO:0002250]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; cellular response to cAMP [GO:0071320]; cytokine production [GO:0001816]; dendritic cell chemotaxis [GO:0002407]; endocytosis [GO:0006897]; G protein-coupled receptor signaling pathway [GO:0007186]; hepatocyte apoptotic process [GO:0097284]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; mast cell degranulation [GO:0043303]; natural killer cell chemotaxis [GO:0035747]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of fibroblast apoptotic process [GO:2000270]; negative regulation of triglyceride catabolic process [GO:0010897]; neutrophil chemotaxis [GO:0030593]; neutrophil extravasation [GO:0072672]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of protein kinase B signaling [GO:0051897]; protein phosphorylation [GO:0006468]; regulation of calcium ion transmembrane transport [GO:1903169]; regulation of cell adhesion mediated by integrin [GO:0033628]; respiratory burst involved in defense response [GO:0002679]; secretory granule localization [GO:0032252]; T cell activation [GO:0042110]; T cell chemotaxis [GO:0010818]; T cell proliferation [GO:0042098]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.


uniprotID: Q9HB21
geneSymbol: PLEKHA1
reactome: R-HSA-1660499;
pdb: 1EAZ;
length: 404
go: ENSG00000107679;
drug: DB04272;
snps: rs1045216
name:
Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; androgen metabolic process [GO:0008209]; B cell receptor signaling pathway [GO:0050853]; cellular response to hydrogen peroxide [GO:0070301]; establishment of protein localization [GO:0045184]; estrogen metabolic process [GO:0008210]; face morphogenesis [GO:0060325]; Leydig cell differentiation [GO:0033327]; luteinization [GO:0001553]; multicellular organism growth [GO:0035264]; negative regulation of protein kinase B signaling [GO:0051898]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol biosynthetic process [GO:0006661]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; post-embryonic development [GO:0009791]; roof of mouth development [GO:0060021]; ruffle organization [GO:0031529]; skeletal system morphogenesis [GO:0048705]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HB21-1; Sequence=Displayed; Name=2; IsoId=Q9HB21-2; Sequence=VSP_043091; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}; Peripheral membrane protein. Nucleus {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000269|PubMed:11802782}.


uniprotID: Q9NW61
geneSymbol: PLEKHJ1
length: 149
name:
Pleckstrin homology domain-containing family J member 1 (PH domain-containing family J member 1) (Guanine nucleotide-releasing protein x)

sequence:
MRYNEKELQALSRQPAEMAAELGMRGPKKGSVLKRRLVKLVVNFLFYFRTDEAEPVGALLLERCRVVREEPGTFSISFIEDPERKYHFECSSEEQCQEWMEALRRASYEFMRRSLIFYRNEIRKVTGKDPLEQFGISEEARFQLSGLQA

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; endosome organization [GO:0007032]; receptor recycling [GO:0001881]; retrograde transport, endosome to Golgi [GO:0042147]


uniprotID: Q96JA3
geneSymbol: PLEKHA8
reactome: R-HSA-1660499;
pdb: 5KDI;
length: 519
go: ENSG00000106086;
name:
Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)

sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; trans-Golgi network [GO:0005802]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transporter activity [GO:1902388]; ceramide binding [GO:0097001]; glycolipid binding [GO:0051861]; glycolipid transporter activity [GO:0017089]; intermembrane lipid transfer activity [GO:0120013]; lipid binding [GO:0008289]; phosphatidylinositol-4-phosphate binding [GO:0070273]; ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]; lipid transport [GO:0006869]; phosphatidylinositol biosynthetic process [GO:0006661]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96JA3-1; Sequence=Displayed; Name=2; IsoId=Q96JA3-2; Sequence=VSP_028545, VSP_028546; Note=No experimental confirmation available.; Name=3; IsoId=Q96JA3-3; Sequence=VSP_028543, VSP_028544; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Binds through its PH domain to PtdIns(4)P and ARF1, and subsequently localizes to TGN exit sites. {ECO:0000269|PubMed:15107860}.


uniprotID: O95397
geneSymbol: PLEKHA8P1
name: Putative protein PLEKHA9 (Pleckstrin homology domain-containing family A member 8 pseudogene 1)
length: 391
sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; ceramide 1-phosphate binding [GO:1902387]; ceramide 1-phosphate transporter activity [GO:1902388]; intermembrane lipid transfer activity [GO:0120013]; lipid binding [GO:0008289]; ceramide transport [GO:0035627]; ER to Golgi ceramide transport [GO:0035621]; intermembrane lipid transfer [GO:0120009]


uniprotID: Q9UF11
geneSymbol: PLEKHB1
length: 243
go: ENSG00000021300;
name:
Pleckstrin homology domain-containing family B member 1 (PH domain-containing family B member 1) (Evectin-1) (PH domain-containing protein in retina 1) (PHRET1) (Pleckstrin homology domain retinal protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; multicellular organism development [GO:0007275]; phototransduction [GO:0007602]; regulation of cell differentiation [GO:0045595]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UF11-1; Sequence=Displayed; Name=2; IsoId=Q9UF11-2; Sequence=VSP_009780; Name=3; IsoId=Q9UF11-3; Sequence=VSP_009779; Name=4; IsoId=Q9UF11-4; Sequence=VSP_009779, VSP_009780; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10585447}. Cytoplasm {ECO:0000250|UniProtKB:Q9QYE9}. Note=Localizes to the apical juxta-nuclear Golgi region of the cytoplasm (By similarity). Membrane-associated (PubMed:10585447). Highly expressed in the outer segments of photoreceptor cells, both in rods and cones (PubMed:10585447). {ECO:0000250|UniProtKB:Q9QYE9, ECO:0000269|PubMed:10585447}.


uniprotID: Q96CS7
geneSymbol: PLEKHB2
pdb: 3AJ4;3VIA;
length: 222
go: ENSG00000115762;
name:
Pleckstrin homology domain-containing family B member 2 (PH domain-containing family B member 2) (Evectin-2)

sequence:

opentargets:
integral component of membrane [GO:0016021]; recycling endosome membrane [GO:0055038]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; regulation of cell differentiation [GO:0045595]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q96CS7-1; Sequence=Displayed; Name=2; IsoId=Q96CS7-2; Sequence=VSP_009783; Note=No experimental confirmation available.; Name=3; IsoId=Q96CS7-3; Sequence=VSP_009784; Note=No experimental confirmation available.; Name=4; IsoId=Q96CS7-4; Sequence=VSP_045163; Name=5; IsoId=Q96CS7-5; Sequence=VSP_045164; Name=6; IsoId=Q96CS7-6; Sequence=VSP_047118; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}; Peripheral membrane protein {ECO:0000269|PubMed:21911378, ECO:0000269|PubMed:22281740}. Note=Specifically detected in tubulovesicular structures, and colocalizes with TFNR.


uniprotID: Q494U1
geneSymbol: PLEKHN1
length: 611
go: ENSG00000187583;
snps: rs3829740
name:
Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein)

sequence:

opentargets:
cytoskeleton [GO:0005856]; mitochondrial membrane [GO:0031966]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; phosphatidylinositol phosphate binding [GO:1901981]; phosphatidylserine binding [GO:0001786]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; positive regulation of apoptotic process [GO:0043065]; response to hypoxia [GO:0001666]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q494U1-1; Sequence=Displayed; Name=2; IsoId=Q494U1-2; Sequence=VSP_059838, VSP_059839; Name=3; IsoId=Q494U1-3; Sequence=VSP_059839, VSP_059840; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25043870}; Lipid-anchor {ECO:0000269|PubMed:25043870}. Mitochondrion {ECO:0000269|PubMed:27616329, ECO:0000269|PubMed:29531808}. Mitochondrion membrane {ECO:0000269|PubMed:18191643, ECO:0000269|PubMed:29180010}. Note=Interaction with C1QBP and phosphorylation is essential for its mitochondrial localization. Localizes on the microtubule in the form of small granules. {ECO:0000269|PubMed:18191643}.


uniprotID: Q16513
geneSymbol: PKN2
reactome: R-HSA-5625740;
pdb: 4CRS;4RRV;6CCY;
length: 984
go: ENSG00000065243;
snps: rs12039846 rs35207128 rs12085658
name:
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)

sequence:

opentargets:
apical junction complex [GO:0043296]; centrosome [GO:0005813]; cleavage furrow [GO:0032154]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; intermediate filament cytoskeleton [GO:0045111]; lamellipodium [GO:0030027]; midbody [GO:0030496]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; GTP-Rho binding [GO:0017049]; histone deacetylase binding [GO:0042826]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; protein kinase C activity [GO:0004697]; protein serine/threonine kinase activity [GO:0004674]; RNA binding [GO:0003723]; RNA polymerase binding [GO:0070063]; apical junction assembly [GO:0043297]; apoptotic process [GO:0006915]; cell adhesion [GO:0007155]; cell cycle [GO:0007049]; cell division [GO:0051301]; cell projection organization [GO:0030030]; epithelial cell migration [GO:0010631]; intracellular signal transduction [GO:0035556]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of cytokinesis [GO:0032467]; positive regulation of mitotic cell cycle [GO:0045931]; positive regulation of viral genome replication [GO:0045070]; protein phosphorylation [GO:0006468]; regulation of cell motility [GO:2000145]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q16513-1; Sequence=Displayed; Name=2; IsoId=Q16513-2; Sequence=VSP_042183; Name=3; IsoId=Q16513-3; Sequence=VSP_042184; Name=4; IsoId=Q16513-4; Sequence=VSP_042181; Name=5; IsoId=Q16513-5; Sequence=VSP_042180, VSP_042182; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11356191, ECO:0000269|PubMed:17332740}. Nucleus {ECO:0000269|PubMed:11356191}. Membrane {ECO:0000250|UniProtKB:Q8BWW9}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Cell junction {ECO:0000269|PubMed:20974804}. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. {ECO:0000269|PubMed:11356191, ECO:0000269|PubMed:17332740}.


uniprotID: Q9H8W4
geneSymbol: PLEKHF2
length: 249
go: ENSG00000175895;
name:
Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18)

sequence:

opentargets:
early endosome membrane [GO:0031901]; endoplasmic reticulum [GO:0005783]; transport vesicle [GO:0030133]; metal ion binding [GO:0046872]; phosphatidylinositol binding [GO:0035091]; protein transport [GO:0015031]

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}; Peripheral membrane protein {ECO:0000305|PubMed:19995552, ECO:0000305|PubMed:22816767}. Endoplasmic reticulum {ECO:0000269|PubMed:18288467}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots (PubMed:19995552). May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552}.


uniprotID: A1L390
geneSymbol: PLEKHG3
name: Pleckstrin homology domain-containing family G member 3 (PH domain-containing family G member 3)
length: 1219
go: ENSG00000126822;
snps: rs41309246 rs229649
sequence:

opentargets:
Rho guanyl-nucleotide exchange factor activity [GO:0005089]; regulation of Rho protein signal transduction [GO:0035023]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A1L390-1; Sequence=Displayed; Name=2; IsoId=A1L390-2; Sequence=VSP_028533, VSP_041513; Name=3; IsoId=A1L390-3; Sequence=VSP_028534; Note=No experimental confirmation available.; 


uniprotID: Q13393
geneSymbol: PLD1
reactome: R-HSA-1483148;R-HSA-1483166;R-HSA-2029485;R-HSA-6798695;
length: 1074
go: ENSG00000075651;
drug: DB00122;DB05301;DB09031;
snps: rs9819927 rs769669104 rs2290480 rs2287579 rs9827333
name:
Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cholinergic synapse [GO:0098981]; endocytic vesicle [GO:0030139]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; tertiary granule membrane [GO:0070821]; N-acylphosphatidylethanolamine-specific phospholipase D activity [GO:0070290]; phosphatidylinositol binding [GO:0035091]; phospholipase D activity [GO:0004630]; cell motility [GO:0048870]; chemotaxis [GO:0006935]; inositol lipid-mediated signaling [GO:0048017]; lipid catabolic process [GO:0016042]; neutrophil degranulation [GO:0043312]; phosphatidic acid biosynthetic process [GO:0006654]; Ras protein signal transduction [GO:0007265]; regulation of microvillus assembly [GO:0032534]; regulation of synaptic vesicle cycle [GO:0098693]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=PLD1A; IsoId=Q13393-1; Sequence=Displayed; Name=PLD1B; IsoId=Q13393-2; Sequence=VSP_005020; Name=PLD1C; IsoId=Q13393-3; Sequence=VSP_005018, VSP_005019; Name=PLD1D; IsoId=Q13393-4; Sequence=VSP_005021, VSP_005022; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Late endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q15149
geneSymbol: PLEC
reactome: R-HSA-2022090;R-HSA-264870;R-HSA-446107;
pdb: 1MB8;2N03;2ODU;2ODV;3F7P;3PDY;3PE0;4GDO;4Q58;4Q59;5J1F;5J1G;5J1H;5J1I;
name: Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
length: 4684
go: ENSG00000178209;
sequence:

opentargets:
brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; actin binding [GO:0003779]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; wound healing [GO:0042060]

snps:
rs200335928 rs11136336 rs3135109 rs11136334 rs55895668 rs200543521 rs80338756 rs34893635 rs7002002 rs7833924 rs35723243 rs6558407 rs35027700 rs35858667 rs34725742 rs35261863 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Name=1; Synonyms=Plectin-6; IsoId=Q15149-1; Sequence=Displayed; Name=2; Synonyms=Plectin-1, 1c; IsoId=Q15149-2; Sequence=VSP_005030; Name=3; IsoId=Q15149-3; Sequence=VSP_005030, VSP_005031; Name=4; Synonyms=Plectin-11, 1a; IsoId=Q15149-4; Sequence=VSP_023510; Name=5; Synonyms=Plectin-8, 1b; IsoId=Q15149-5; Sequence=VSP_037103, VSP_037106; Name=6; Synonyms=Plectin-10, 1g; IsoId=Q15149-6; Sequence=VSP_037104, VSP_037105; Name=7; Synonyms=Plectin-7, 1d; IsoId=Q15149-7; Sequence=VSP_037100, VSP_037109; Name=8; Synonyms=Plectin-3, 1e; IsoId=Q15149-8; Sequence=VSP_037101, VSP_037108; Name=9; Synonyms=Plectin-2, 1f; IsoId=Q15149-9; Sequence=VSP_037102, VSP_037107; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12482924}. Cell junction, hemidesmosome {ECO:0000269|PubMed:12482924}.


uniprotID: P08567
geneSymbol: PLEK
reactome: R-HSA-114608;
pdb: 1PLS;1W4M;1X05;1XX0;1ZM0;2CSO;2I5C;2I5F;
name: Pleckstrin (Platelet 47 kDa protein) (p47)
length: 350
go: ENSG00000115956;
snps: rs17035364 rs3816281 rs34515106 rs1063479
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular region [GO:0005576]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; protein homodimerization activity [GO:0042803]; protein kinase C binding [GO:0005080]; actin cytoskeleton reorganization [GO:0031532]; cell projection organization [GO:0030030]; cortical actin cytoskeleton organization [GO:0030866]; hematopoietic progenitor cell differentiation [GO:0002244]; integrin-mediated signaling pathway [GO:0007229]; negative regulation of calcium-mediated signaling [GO:0050849]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of inositol phosphate biosynthetic process [GO:0010920]; phosphatidylinositol metabolic process [GO:0046488]; phospholipase C-inhibiting G protein-coupled receptor signaling pathway [GO:0030845]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of inositol-polyphosphate 5-phosphatase activity [GO:0010925]; positive regulation of integrin activation [GO:0033625]; positive regulation of platelet activation [GO:0010572]; protein kinase C signaling [GO:0070528]; protein secretion by platelet [GO:0070560]; regulation of cell diameter [GO:0060305]; ruffle organization [GO:0031529]; thrombin-activated receptor signaling pathway [GO:0070493]; vesicle docking involved in exocytosis [GO:0006904]


uniprotID: P53350
geneSymbol: PLK1
length: 603
go: ENSG00000166851;
snps: rs35056440 rs16972799 rs45489499 rs45569335 rs56027600 rs34001032 rs34954545
reactome:
R-HSA-141444;R-HSA-156711;R-HSA-162658;R-HSA-174178;R-HSA-176412;R-HSA-176417;R-HSA-2299718;R-HSA-2467813;R-HSA-2500257;R-HSA-2565942;R-HSA-2980767;R-HSA-380259;R-HSA-380270;R-HSA-380284;R-HSA-380320;R-HSA-5620912;R-HSA-5663220;R-HSA-68877;R-HSA-68881;R-HSA-68884;R-HSA-69273;R-HSA-8852276;R-HSA-8854518;

pdb:
1Q4K;1Q4O;1UMW;2OGQ;2OJX;2OU7;2OWB;2RKU;2V5Q;2YAC;3BZI;3C5L;3FC2;3FVH;3HIH;3HIK;3KB7;3P2W;3P2Z;3P34;3P35;3P36;3P37;3Q1I;3RQ7;3THB;4A4L;4A4O;4DFW;4E67;4E9C;4E9D;4H5X;4H71;4HAB;4HCO;4HY2;4J52;4J53;4LKL;4LKM;4O56;4O6W;4O9W;4RCP;4WHH;4WHK;4WHL;4X9R;4X9V;4X9W;5J19;5NEI;5NFU;5NJE;5NMM;5NN1;5NN2;5TA6;5TA8;6AX4;

name:
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)

sequence:

opentargets:
centriolar satellite [GO:0034451]; centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; condensed nuclear chromosome outer kinetochore [GO:0000942]; cytosol [GO:0005829]; kinetochore [GO:0000776]; microtubule cytoskeleton [GO:0015630]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; spindle [GO:0005819]; spindle midzone [GO:0051233]; spindle pole [GO:0000922]; synaptonemal complex [GO:0000795]; anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; microtubule binding [GO:0008017]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell proliferation [GO:0008283]; centrosome cycle [GO:0007098]; ciliary basal body-plasma membrane docking [GO:0097711]; establishment of protein localization [GO:0045184]; female meiosis chromosome segregation [GO:0016321]; G2/M transition of mitotic cell cycle [GO:0000086]; homologous chromosome segregation [GO:0045143]; microtubule bundle formation [GO:0001578]; mitotic cell cycle [GO:0000278]; mitotic cytokinesis [GO:0000281]; mitotic nuclear envelope disassembly [GO:0007077]; mitotic sister chromatid segregation [GO:0000070]; mitotic spindle assembly checkpoint [GO:0007094]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nuclear envelope disassembly [GO:0051081]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein localization to nucleus [GO:1900182]; positive regulation of proteolysis [GO:0045862]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; positive regulation of ubiquitin-protein transferase activity [GO:0051443]; protein destabilization [GO:0031648]; protein localization to chromatin [GO:0071168]; protein localization to nuclear envelope [GO:0090435]; protein phosphorylation [GO:0006468]; protein ubiquitination [GO:0016567]; regulation of cell cycle [GO:0051726]; regulation of cell cycle G2/M phase transition [GO:1902749]; regulation of cytokinesis [GO:0032465]; regulation of G2/M transition of mitotic cell cycle [GO:0010389]; regulation of mitotic cell cycle [GO:0007346]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein binding [GO:0043393]; signal transduction involved in G2 DNA damage checkpoint [GO:0072425]; sister chromatid cohesion [GO:0007062]; synaptonemal complex disassembly [GO:0070194]

location:
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:24018379}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18794143}. Midbody. Note=localization at the centrosome starts at the G1/S transition (PubMed:24018379). During early stages of mitosis, the phosphorylated form is detected on centrosomes and kinetochores. Localizes to the outer kinetochore. Presence of SGO1 and interaction with the phosphorylated form of BUB1 is required for the kinetochore localization. Localizes onto the central spindle by phosphorylating and docking at midzone proteins KIF20A/MKLP2 and PRC1. Colocalizes with FRY to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle. Localization to the centrosome is required for S phase progression (PubMed:24018379). Colocalizes with HSF1 at the spindle poles during prometaphase (PubMed:18794143). {ECO:0000269|PubMed:18794143, ECO:0000269|PubMed:24018379}.


uniprotID: Q9NYY3
geneSymbol: PLK2
reactome: R-HSA-6804115;
pdb: 4I5M;4I5P;4I6B;4I6F;4I6H;4RS6;4XB0;
length: 685
go: ENSG00000145632;
snps: rs55768901 rs55645589
name:
Serine/threonine-protein kinase PLK2 (EC 2.7.11.21) (Polo-like kinase 2) (PLK-2) (hPlk2) (Serine/threonine-protein kinase SNK) (hSNK) (Serum-inducible kinase)

sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; chromatin [GO:0000785]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; intracellular [GO:0005622]; ATP binding [GO:0005524]; ATP-dependent protein binding [GO:0043008]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; G1/S transition of mitotic cell cycle [GO:0000082]; long-term synaptic depression [GO:0060292]; long-term synaptic potentiation [GO:0060291]; memory [GO:0007613]; mitotic cell cycle checkpoint [GO:0007093]; mitotic spindle organization [GO:0007052]; negative regulation of angiogenesis [GO:0016525]; negative regulation of apoptotic process [GO:0043066]; negative regulation of apoptotic process in bone marrow [GO:0071866]; negative regulation of cellular senescence [GO:2000773]; negative regulation of dendritic spine development [GO:0061000]; peptidyl-serine phosphorylation [GO:0018105]; positive regulation of autophagy [GO:0010508]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein binding [GO:0032092]; positive regulation of protein catabolic process [GO:0045732]; protein phosphorylation [GO:0006468]; Rap protein signal transduction [GO:0032486]; Ras protein signal transduction [GO:0007265]; regulation of centriole replication [GO:0046599]; regulation of synaptic plasticity [GO:0048167]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15242618, ECO:0000269|PubMed:19001868}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.


uniprotID: Q9H4B4
geneSymbol: PLK3
reactome: R-HSA-6804115;R-HSA-6804756;
pdb: 4B6L;
length: 646
go: ENSG00000173846;
snps: rs17884581 rs17884316 rs17880471 rs17884653 rs17855444 rs17880829 rs17881786
name:
Serine/threonine-protein kinase PLK3 (EC 2.7.11.21) (Cytokine-inducible serine/threonine-protein kinase) (FGF-inducible kinase) (Polo-like kinase 3) (PLK-3) (Proliferation-related kinase)

sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; Golgi stack [GO:0005795]; neuronal cell body [GO:0043025]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; p53 binding [GO:0002039]; protein serine/threonine kinase activity [GO:0004674]; apoptotic process [GO:0006915]; cellular response to DNA damage stimulus [GO:0006974]; cytoplasmic microtubule organization [GO:0031122]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; endomitotic cell cycle [GO:0007113]; G1/S transition of mitotic cell cycle [GO:0000082]; G2/M transition of mitotic cell cycle [GO:0000086]; Golgi disassembly [GO:0090166]; mitotic cell cycle checkpoint [GO:0007093]; mitotic G1/S transition checkpoint [GO:0044819]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of chaperone-mediated autophagy [GO:1904716]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia [GO:2000777]; protein kinase B signaling [GO:0043491]; protein phosphorylation [GO:0006468]; regulation of cell division [GO:0051302]; regulation of cytokinesis [GO:0032465]; regulation of signal transduction by p53 class mediator [GO:1901796]; response to osmotic stress [GO:0006970]; response to radiation [GO:0009314]; response to reactive oxygen species [GO:0000302]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. {ECO:0000269|PubMed:17264206}.


uniprotID: O00168
geneSymbol: FXYD1
reactome: R-HSA-5578775;R-HSA-936837;
pdb: 2J1I;2JO1;
sequence: MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
length: 92
go: ENSG00000266964;
name:
Phospholemman (FXYD domain-containing ion transport regulator 1) (Sodium/potassium-transporting ATPase subunit FXYD1)

opentargets:
apical plasma membrane [GO:0016324]; caveola [GO:0005901]; integral component of plasma membrane [GO:0005887]; intercalated disc [GO:0014704]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sodium:potassium-exchanging ATPase complex [GO:0005890]; T-tubule [GO:0030315]; chloride channel activity [GO:0005254]; ion channel binding [GO:0044325]; sodium channel regulator activity [GO:0017080]; chloride transport [GO:0006821]; muscle contraction [GO:0006936]; negative regulation of protein glutathionylation [GO:0010734]; positive regulation of sodium ion export across plasma membrane [GO:1903278]; potassium ion transport [GO:0006813]; regulation of cardiac muscle cell membrane potential [GO:0086036]; regulation of heart contraction [GO:0008016]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; sodium ion transport [GO:0006814]

location:
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.


uniprotID: O15162
geneSymbol: PLSCR1
pdb: 1Y2A;
length: 318
go: ENSG00000188313;
snps: rs343320
name:
Phospholipid scramblase 1 (PL scramblase 1) (Ca(2+)-dependent phospholipid scramblase 1) (Erythrocyte phospholipid scramblase) (MmTRA1b)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; membrane raft [GO:0045121]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; calcium ion binding [GO:0005509]; CD4 receptor binding [GO:0042609]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; epidermal growth factor receptor binding [GO:0005154]; phospholipid scramblase activity [GO:0017128]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; SH3 domain binding [GO:0017124]; acute-phase response [GO:0006953]; apoptotic process [GO:0006915]; defense response to virus [GO:0051607]; negative regulation of viral genome replication [GO:0045071]; phosphatidylserine biosynthetic process [GO:0006659]; phospholipid scrambling [GO:0017121]; platelet activation [GO:0030168]; positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity [GO:2000373]; positive regulation of gene expression [GO:0010628]; positive regulation of innate immune response [GO:0045089]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of Fc receptor mediated stimulatory signaling pathway [GO:0060368]; regulation of mast cell activation [GO:0033003]; response to interferon-beta [GO:0035456]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15162-1; Sequence=Displayed; Name=2; IsoId=O15162-2; Sequence=VSP_055237, VSP_055238; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22052202}; Single-pass type II membrane protein. Membrane; Lipid-anchor; Cytoplasmic side. Nucleus. Cytoplasm {ECO:0000269|PubMed:22052202}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22052202}. Note=Localizes to the perinuclear region in the presence of RELT. {ECO:0000269|PubMed:22052202}.


uniprotID: Q9BVG9
geneSymbol: PTDSS2
reactome: R-HSA-1483101;
name: Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II)
length: 487
go: ENSG00000174915;
drug: DB00144;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; CDP-diacylglycerol-serine O-phosphatidyltransferase activity [GO:0003882]; transferase activity [GO:0016740]; phosphatidylserine biosynthetic process [GO:0006659]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Highly enriched in the mitochondria-associated membrane (MAM). {ECO:0000250}.


uniprotID: P26022
geneSymbol: PTX3
reactome: R-HSA-6798695;
length: 381
go: ENSG00000163661;
snps: rs34655398 rs3816527 rs35415718 rs4478039
location: SUBCELLULAR LOCATION: Secreted.
name:
Pentraxin-related protein PTX3 (Pentaxin-related protein PTX3) (Tumor necrosis factor alpha-induced protein 5) (TNF alpha-induced protein 5) (Tumor necrosis factor-inducible gene 14 protein) (TSG-14)

sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; specific granule lumen [GO:0035580]; tertiary granule lumen [GO:1904724]; (1->3)-beta-D-glucan binding [GO:0001872]; complement component C1q binding [GO:0001849]; identical protein binding [GO:0042802]; virion binding [GO:0046790]; extracellular matrix organization [GO:0030198]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; negative regulation by host of viral exo-alpha-sialidase activity [GO:0044869]; negative regulation by host of viral glycoprotein metabolic process [GO:0044871]; negative regulation of exo-alpha-sialidase activity [GO:1903016]; negative regulation of glycoprotein metabolic process [GO:1903019]; negative regulation of viral entry into host cell [GO:0046597]; neutrophil degranulation [GO:0043312]; opsonization [GO:0008228]; ovarian cumulus expansion [GO:0001550]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of phagocytosis [GO:0050766]; response to yeast [GO:0001878]


uniprotID: Q96A99
geneSymbol: PTX4
name: Pentraxin-4
length: 478
go: ENSG00000251692;
opentargets: extracellular region [GO:0005576]; metal ion binding [GO:0046872]
snps: rs2745103 rs2745101 rs2667673 rs12445920 rs2745098 rs13332460 rs59554810
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; Synonyms=PTX4(2); IsoId=Q96A99-1; Sequence=Displayed; Name=1; Synonyms=PTX4(1), Long; IsoId=Q96A99-2; Sequence=VSP_040203; Note=Not expressed in small intestine. {ECO:0000305|PubMed:20357257}; 


uniprotID: Q96PD5
geneSymbol: PGLYRP2
reactome: R-HSA-6803157;
length: 576
go: ENSG00000161031;
snps: rs3813135 rs733731 rs28404490 rs892145 rs34440547 rs2304200
location: SUBCELLULAR LOCATION: Secreted. Membrane.
name:
N-acetylmuramoyl-L-alanine amidase (EC 3.5.1.28) (Peptidoglycan recognition protein 2) (Peptidoglycan recognition protein long) (PGRP-L)

sequence:

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; membrane [GO:0016020]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan receptor activity [GO:0016019]; zinc ion binding [GO:0008270]; antimicrobial humoral response [GO:0019730]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; growth of symbiont in host [GO:0044117]; innate immune response [GO:0045087]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; peptide amidation [GO:0001519]; peptidoglycan catabolic process [GO:0009253]; regulation of inflammatory response [GO:0050727]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96PD5-1; Sequence=Displayed; Note=Major isoform.; Name=2; IsoId=Q96PD5-2; Sequence=VSP_008964; Note=May be due to an intron retention. No experimental confirmation available.; 


uniprotID: Q96LB9
geneSymbol: PGLYRP3
reactome: R-HSA-6803157;
pdb: 1SK3;1SK4;1TWQ;2APH;
length: 341
go: ENSG00000159527;
snps: rs55991125 rs843971
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}.
name:
Peptidoglycan recognition protein 3 (Peptidoglycan recognition protein I-alpha) (PGLYRPIalpha) (PGRP-I-alpha) (Peptidoglycan recognition protein intermediate alpha)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; growth of symbiont in host [GO:0044117]; innate immune response [GO:0045087]; killing of cells of other organism [GO:0031640]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; peptidoglycan catabolic process [GO:0009253]; positive regulation of cytolysis in other organism [GO:0051714]


uniprotID: Q96LB8
geneSymbol: PGLYRP4
reactome: R-HSA-6803157;
pdb: 2EAV;2EAX;
length: 373
go: ENSG00000163218;
snps: rs12096209 rs3006458 rs3006453 rs3006448 rs12063091 rs35347202
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16354652}.
name:
Peptidoglycan recognition protein 4 (Peptidoglycan recognition protein I-beta) (PGLYRPIbeta) (PGRP-I-beta) (Peptidoglycan recognition protein intermediate beta)

sequence:

opentargets:
extracellular space [GO:0005615]; intracellular [GO:0005622]; membrane [GO:0016020]; protein-containing complex [GO:0032991]; N-acetylmuramoyl-L-alanine amidase activity [GO:0008745]; peptidoglycan binding [GO:0042834]; peptidoglycan receptor activity [GO:0016019]; protein heterodimerization activity [GO:0046982]; zinc ion binding [GO:0008270]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; defense response to Gram-positive bacterium [GO:0050830]; detection of bacterium [GO:0016045]; innate immune response [GO:0045087]; killing of cells of other organism [GO:0031640]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of natural killer cell differentiation involved in immune response [GO:0032827]; peptidoglycan catabolic process [GO:0009253]; positive regulation of cytolysis in other organism [GO:0051714]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96LB8-1; Sequence=Displayed; Name=2; IsoId=Q96LB8-2; Sequence=VSP_024388; 


uniprotID: Q14671
geneSymbol: PUM1
reactome: R-HSA-432722;
pdb: 1IB2;1M8W;1M8X;1M8Y;1M8Z;2YJY;3BSB;3BSX;3Q0L;3Q0M;3Q0N;3Q0O;3Q0P;5YKH;5YKI;
name: Pumilio homolog 1 (HsPUM) (Pumilio-1)
length: 1186
go: ENSG00000134644;
sequence:

opentargets:
cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; adult locomotory behavior [GO:0008344]; mRNA destabilization [GO:0061157]; positive regulation of gene silencing by miRNA [GO:2000637]; positive regulation of RIG-I signaling pathway [GO:1900246]; posttranscriptional gene silencing [GO:0016441]; posttranscriptional regulation of gene expression [GO:0010608]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]; regulation of cell cycle [GO:0051726]; regulation of chromosome segregation [GO:0051983]; regulation of gene silencing by miRNA [GO:0060964]; regulation of mRNA stability [GO:0043488]; spermatogenesis [GO:0007283]; stem cell differentiation [GO:0048863]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q14671-1; Sequence=Displayed; Name=2; IsoId=Q14671-2; Sequence=VSP_017059, VSP_017060, VSP_017061; Note=No experimental confirmation available.; Name=3; IsoId=Q14671-3; Sequence=VSP_017061; Note=No experimental confirmation available.; Name=4; IsoId=Q14671-4; Sequence=VSP_053703, VSP_053704, VSP_017059; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:26724866}. Cytoplasm, P-body {ECO:0000305|PubMed:20818387}. Cytoplasmic granule {ECO:0000269|PubMed:25340845}. Note=Recruited to cytoplasmic stress granules upon viral infection. {ECO:0000269|PubMed:25340845}.


uniprotID: Q8N6C7
geneSymbol: MIR7-3HG
name: Putative uncharacterized protein encoded by MIR7-3HG (Pituitary gland-specific factor 1)
length: 128
snps: rs11878617 rs3760955
sequence:
MPGMRLVCRLAHGHFPRKGQRRRSLTVWKAETSRADCLGAPNIRTAPLGRSEKRTAICFSTGAQDSSQRAPFRLQNPGQLLQLGMHSLHLHPELPTTDPAFFCKLHFIKGNDPYCLTISHVKSVLTFS

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=PGSF1a; IsoId=Q8N6C7-1; Sequence=Displayed; Name=2; Synonyms=PGSF1b; IsoId=Q8N6C7-2; Sequence=VSP_014375, VSP_014376; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q9C0D0
geneSymbol: PHACTR1
name: Phosphatase and actin regulator 1
length: 580
go: ENSG00000112137;
snps: rs17602409 rs748743403
sequence:

opentargets:
cell junction [GO:0030054]; cytosol [GO:0005829]; nucleus [GO:0005634]; synapse [GO:0045202]; actin binding [GO:0003779]; protein phosphatase 1 binding [GO:0008157]; protein phosphatase inhibitor activity [GO:0004864]; actin cytoskeleton reorganization [GO:0031532]; actomyosin structure organization [GO:0031032]; cell motility [GO:0048870]; stress fiber assembly [GO:0043149]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9C0D0-1; Sequence=Displayed; Name=2; IsoId=Q9C0D0-2; Sequence=VSP_018529, VSP_018530; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import (By similarity). {ECO:0000250}.


uniprotID: P35232
geneSymbol: PHB
reactome: R-HSA-5673000;R-HSA-6802946;R-HSA-6802949;R-HSA-6802955;R-HSA-8949664;
pdb: 1LU7;
name: Prohibitin
length: 272
go: ENSG00000167085;
snps: rs121918373 rs121918372
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}.
sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; extrinsic component of mitochondrial outer membrane [GO:0031315]; extrinsic component of presynaptic active zone membrane [GO:0098891]; GABA-ergic synapse [GO:0098982]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; mitochondrial crista [GO:0030061]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; complement component C3a binding [GO:0001850]; complement component C3b binding [GO:0001851]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enzyme binding [GO:0019899]; histone deacetylase binding [GO:0042826]; protein C-terminus binding [GO:0008022]; proteinase activated receptor binding [GO:0031871]; transcription regulatory region DNA binding [GO:0044212]; animal organ regeneration [GO:0031100]; cellular response to interleukin-6 [GO:0071354]; DNA biosynthetic process [GO:0071897]; histone deacetylation [GO:0016575]; mitochondrial calcium ion transmembrane transport [GO:0006851]; mitochondrion organization [GO:0007005]; negative regulation of androgen receptor signaling pathway [GO:0060766]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation [GO:0008285]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of glucocorticoid receptor signaling pathway [GO:2000323]; negative regulation of protein catabolic process [GO:0042177]; negative regulation of transcription by competitive promoter binding [GO:0010944]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; osteoblast differentiation [GO:0001649]; ovarian follicle atresia [GO:0001552]; ovarian follicle development [GO:0001541]; positive regulation of cell death [GO:0010942]; positive regulation of complement activation [GO:0045917]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of G protein-coupled receptor signaling pathway [GO:0045745]; positive regulation of gene expression [GO:0010628]; positive regulation of transcription, DNA-templated [GO:0045893]; progesterone receptor signaling pathway [GO:0050847]; protein stabilization [GO:0050821]; regulation of apoptotic process [GO:0042981]; regulation of transcription, DNA-templated [GO:0006355]; response to ethanol [GO:0045471]; response to immobilization stress [GO:0035902]; response to peptide hormone [GO:0043434]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P35232-1; Sequence=Displayed; Name=2; IsoId=P35232-2; Sequence=VSP_054922; Note=No experimental confirmation available.; 


uniprotID: Q8NDX5
geneSymbol: PHC3
pdb: 4PZN;4PZO;
length: 983
go: ENSG00000173889;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12167701, ECO:0000269|PubMed:21282530}.
name:
Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PcG protein complex [GO:0031519]; PRC1 complex [GO:0035102]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; multicellular organism development [GO:0007275]; negative regulation of G0 to G1 transition [GO:0070317]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q8NDX5-1; Sequence=Displayed; Name=2; IsoId=Q8NDX5-2; Sequence=VSP_016765; Name=3; IsoId=Q8NDX5-3; Sequence=VSP_016763, VSP_016770, VSP_016771; Note=No experimental confirmation available.; Name=4; IsoId=Q8NDX5-4; Sequence=VSP_016764, VSP_016768, VSP_016769; Name=5; IsoId=Q8NDX5-5; Sequence=VSP_016763, VSP_016766, VSP_016767; Name=6; IsoId=Q8NDX5-6; Sequence=VSP_016764, VSP_016766, VSP_016767; Note=No experimental confirmation available.; Name=7; IsoId=Q8NDX5-7; Sequence=VSP_016763; 


uniprotID: P78562
geneSymbol: PHEX
length: 749
go: ENSG00000102174;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
name:
Phosphate-regulating neutral endopeptidase (EC 3.4.24.-) (Metalloendopeptidase homolog PEX) (Vitamin D-resistant hypophosphatemic rickets protein) (X-linked hypophosphatemia protein) (HYP)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; aminopeptidase activity [GO:0004177]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]; bone development [GO:0060348]; bone mineralization [GO:0030282]; cell-cell signaling [GO:0007267]; cellular protein modification process [GO:0006464]; cellular response to parathyroid hormone stimulus [GO:0071374]; cellular response to vitamin D [GO:0071305]; lung development [GO:0030324]; organophosphate metabolic process [GO:0019637]; proteolysis [GO:0006508]; response to growth hormone [GO:0060416]; response to insulin-like growth factor stimulus [GO:1990418]; response to sodium phosphate [GO:1904383]; skeletal system development [GO:0001501]

snps:
rs137853269 rs751230094 rs267606945 rs267606946 rs886041363 rs137853270 rs760870713 rs875989883 rs1057517980 


uniprotID: Q9UIL8
geneSymbol: PHF11
name: PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34)
length: 331
go: ENSG00000136147;
opentargets: nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18405956}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=A number of isoforms may be produced.; Name=1; IsoId=Q9UIL8-1; Sequence=Displayed; Name=2; IsoId=Q9UIL8-2; Sequence=VSP_038088; 


uniprotID: Q06203
geneSymbol: PPAT
reactome: R-HSA-73817;
length: 517
go: ENSG00000128059;
drug: DB00544;DB00130;DB01033;
name:
Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)

sequence:

opentargets:
cytosol [GO:0005829]; 4 iron, 4 sulfur cluster binding [GO:0051539]; amidophosphoribosyltransferase activity [GO:0004044]; metal ion binding [GO:0046872]; 'de novo' IMP biosynthetic process [GO:0006189]; animal organ regeneration [GO:0031100]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; G1/S transition of mitotic cell cycle [GO:0000082]; glutamine catabolic process [GO:0006543]; kidney development [GO:0001822]; lactation [GO:0007595]; maternal process involved in female pregnancy [GO:0060135]; nucleoside metabolic process [GO:0009116]; protein homotetramerization [GO:0051289]; purine nucleobase biosynthetic process [GO:0009113]; purine nucleotide biosynthetic process [GO:0006164]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]


uniprotID: Q7RTV0
geneSymbol: PHF5A
reactome: R-HSA-72163;
pdb: 5IFE;5O9Z;5SYB;5Z56;5Z57;5Z58;5ZYA;6EN4;6FF4;
length: 110
go: ENSG00000100410;
name:
PHD finger-like domain-containing protein 5A (PHD finger-like domain protein 5A) (Splicing factor 3B-associated 14 kDa protein) (SF3b14b)

sequence:
MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR

opentargets:
nuclear matrix [GO:0016363]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; U12-type spliceosomal complex [GO:0005689]; U2 snRNP [GO:0005686]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of transcription, DNA-templated [GO:0045893]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28541300}. Nucleus speckle {ECO:0000250|UniProtKB:P83870}.


uniprotID: Q8WV24
geneSymbol: PHLDA1
reactome: R-HSA-8854521;
length: 401
go: ENSG00000139289;
name:
Pleckstrin homology-like domain family A member 1 (Apoptosis-associated nuclear protein) (Proline- and glutamine-rich protein) (PQ-rich protein) (PQR protein) (Proline- and histidine-rich protein) (T-cell death-associated gene 51 protein)

sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; apoptotic process [GO:0006915]; FasL biosynthetic process [GO:0045210]; G2/M transition of mitotic cell cycle [GO:0000086]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11369516}. Cytoplasmic vesicle {ECO:0000269|PubMed:12738777}. Nucleus, nucleolus {ECO:0000269|PubMed:11369516}. Note=Colocalizes with intracellular vesicles. {ECO:0000269|PubMed:12738777}.


uniprotID: Q9Y5J5
geneSymbol: PHLDA3
name: Pleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1)
length: 127
go: ENSG00000174307;
snps: rs35383942
sequence:
MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS

opentargets:
cytoplasm [GO:0005737]; plasma membrane [GO:0005886]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-5-phosphate binding [GO:0010314]; anatomical structure morphogenesis [GO:0009653]; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:0042771]; negative regulation of protein kinase B signaling [GO:0051898]; positive regulation of apoptotic process [GO:0043065]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.


uniprotID: Q9BWX1
geneSymbol: PHF7
name: PHD finger protein 7 (Testis development protein NYD-SP6)
length: 381
go: ENSG00000010318;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11829468}.
sequence:

opentargets:
cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BWX1-1; Sequence=Displayed; Name=2; IsoId=Q9BWX1-2; Sequence=VSP_046255; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: P80108
geneSymbol: GPLD1
reactome: R-HSA-163125;
length: 840
go: ENSG00000112293;
snps: rs2235501 rs1126617 rs17300770 rs1062496 rs6924628 rs1062505 rs1042303 rs1772256
location: SUBCELLULAR LOCATION: Secreted.
name:
Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) (EC 3.1.4.50) (Glycoprotein phospholipase D) (Glycosyl-phosphatidylinositol-specific phospholipase D) (GPI-PLD) (GPI-specific phospholipase D)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; intracellular membrane-bounded organelle [GO:0043231]; lysosomal membrane [GO:0005765]; glycosylphosphatidylinositol phospholipase D activity [GO:0004621]; phospholipase D activity [GO:0004630]; sodium channel regulator activity [GO:0017080]; C-terminal protein lipidation [GO:0006501]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to calcium ion [GO:0071277]; cellular response to cholesterol [GO:0071397]; cellular response to drug [GO:0035690]; cellular response to insulin stimulus [GO:0032869]; cellular response to pH [GO:0071467]; cellular response to triglyceride [GO:0071401]; chondrocyte differentiation [GO:0002062]; complement receptor mediated signaling pathway [GO:0002430]; GPI anchor release [GO:0006507]; hematopoietic stem cell migration [GO:0035701]; hematopoietic stem cell migration to bone marrow [GO:0097241]; insulin receptor signaling pathway [GO:0008286]; negative regulation of cell proliferation [GO:0008285]; negative regulation of triglyceride catabolic process [GO:0010897]; ossification [GO:0001503]; phosphatidylcholine metabolic process [GO:0046470]; positive regulation of alkaline phosphatase activity [GO:0010694]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cytolysis [GO:0045919]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of glucose metabolic process [GO:0010907]; positive regulation of high-density lipoprotein particle clearance [GO:0010983]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of membrane protein ectodomain proteolysis [GO:0051044]; positive regulation of secretion [GO:0051047]; positive regulation of triglyceride biosynthetic process [GO:0010867]; regulation of cellular response to insulin stimulus [GO:1900076]; response to glucose [GO:0009749]; transepithelial transport [GO:0070633]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P80108-1; Sequence=Displayed; Name=2; IsoId=P80108-2; Sequence=VSP_023261, VSP_023262; 


uniprotID: Q8TCD6
geneSymbol: PHOSPHO2
name: Pyridoxal phosphate phosphatase PHOSPHO2 (EC 3.1.3.74)
length: 241
go: ENSG00000144362;
opentargets: metal ion binding [GO:0046872]; pyridoxal phosphatase activity [GO:0033883]
snps: rs56036676
sequence:


uniprotID: Q5SRE7
geneSymbol: PHYHD1
pdb: 2OPW;3OBZ;
name: Phytanoyl-CoA dioxygenase domain-containing protein 1 (EC 1.-.-.-)
length: 291
go: ENSG00000175287;
opentargets: dioxygenase activity [GO:0051213]; metal ion binding [GO:0046872]
snps: rs10988159
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=A, PHYHD1A; IsoId=Q5SRE7-1; Sequence=Displayed; Name=2; Synonyms=C, PHYHD1C; IsoId=Q5SRE7-2; Sequence=VSP_030077; Name=3; Synonyms=B, PHYHD1B; IsoId=Q5SRE7-3; Sequence=VSP_030078; 


uniprotID: Q6UXB8
geneSymbol: PI16
length: 463
go: ENSG00000164530;
opentargets: extracellular space [GO:0005615]; peptidase inhibitor activity [GO:0030414]
snps: rs1405069 rs16889318
name:
Peptidase inhibitor 16 (PI-16) (Cysteine-rich secretory protein 9) (CRISP-9) (PSP94-binding protein) (CD antigen CD364)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6UXB8-1; Sequence=Displayed; Name=2; IsoId=Q6UXB8-2; Sequence=VSP_025574; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15344909, ECO:0000269|PubMed:17062675, ECO:0000269|PubMed:22171320}.


uniprotID: Q5UE93
geneSymbol: PIK3R6
reactome: R-HSA-114604;R-HSA-1660499;R-HSA-392451;
length: 754
go: ENSG00000276231;
name:
Phosphoinositide 3-kinase regulatory subunit 6 (Phosphoinositide 3-kinase gamma adapter protein of 87 kDa) (p84 PI3K adapter protein) (p84 PIKAP) (p87 PI3K adapter protein) (p87PIKAP)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; phosphatidylinositol 3-kinase complex [GO:0005942]; phosphatidylinositol 3-kinase complex, class IB [GO:0005944]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase regulator activity [GO:0046935]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; angiogenesis [GO:0001525]; G protein-coupled receptor signaling pathway [GO:0007186]; phosphatidylinositol 3-kinase signaling [GO:0014065]; platelet activation [GO:0030168]; positive regulation of angiogenesis [GO:0045766]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of T cell differentiation [GO:0045582]; regulation of natural killer cell mediated cytotoxicity [GO:0042269]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U6Q4}. Cell membrane {ECO:0000250|UniProtKB:Q3U6Q4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3U6Q4}. Note=Translocated to the plasma membrane in a Ras-dependent manner. {ECO:0000250|UniProtKB:Q3U6Q4}.


uniprotID: P78356
geneSymbol: PIP4K2B
reactome: R-HSA-1660499;R-HSA-6811555;R-HSA-6811558;R-HSA-8847453;
pdb: 1BO1;3WZZ;3X01;3X02;3X03;3X04;3X05;3X06;3X07;3X08;3X09;3X0A;3X0B;3X0C;
length: 416
go: ENSG00000276293;
name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)

sequence:

opentargets:
autophagosome [GO:0005776]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-phosphate 4-kinase activity [GO:0052811]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; protein homodimerization activity [GO:0042803]; cell surface receptor signaling pathway [GO:0007166]; phosphatidylinositol biosynthetic process [GO:0006661]; phospholipid metabolic process [GO:0006644]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P78356-1; Sequence=Displayed; Name=2; IsoId=P78356-2; Sequence=VSP_010384, VSP_010385; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20583997}. Cytoplasm {ECO:0000269|PubMed:20583997}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.


uniprotID: Q8TBX8
geneSymbol: PIP4K2C
reactome: R-HSA-1660499;R-HSA-6811555;R-HSA-6811558;R-HSA-8847453;
pdb: 2GK9;
length: 421
go: ENSG00000166908;
snps: rs17550713 rs17852569 rs2277319
name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)

sequence:

opentargets:
autophagosome [GO:0005776]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; 1-phosphatidylinositol-5-phosphate 4-kinase activity [GO:0016309]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of autophagosome assembly [GO:2000786]; regulation of autophagy [GO:0010506]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TBX8-1; Sequence=Displayed; Name=2; IsoId=Q8TBX8-2; Sequence=VSP_042929; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBX8-3; Sequence=VSP_043369; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane. Note=Mostly found in the cytosol and surrounding plasma membrane. However, its presence in the endoplasmic reticulum seems to be a prerequisite for PIP2 synthesis (By similarity). {ECO:0000250}.


uniprotID: P42356
geneSymbol: PI4KA
reactome: R-HSA-1483248;R-HSA-1660514;
pdb: 6BQ1;
length: 2102
go: ENSG00000241973;
snps: rs17819211 rs2539908 rs747119727
name:
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; Golgi-associated vesicle membrane [GO:0030660]; membrane [GO:0016020]; plasma membrane [GO:0005886]; viral replication complex [GO:0019034]; 1-phosphatidylinositol 4-kinase activity [GO:0004430]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; kinase activity [GO:0016301]; multi-organism membrane organization [GO:0044803]; phosphatidylinositol biosynthetic process [GO:0006661]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; signal transduction [GO:0007165]; viral replication complex formation and maintenance [GO:0046786]; viral RNA genome replication [GO:0039694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=PI4K230 {ECO:0000303|PubMed:10101268}; IsoId=P42356-1; Sequence=Displayed; Name=2; Synonyms=PI4K97 {ECO:0000303|PubMed:10101268}; IsoId=P42356-2; Sequence=VSP_008805; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. Cell membrane {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:24417819}. Note=Localization to the plasma membrane is mediated by the PI4K complex and association with EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899). Localization to the plasma membrane is regulated by TMEM150A (PubMed:25608530). {ECO:0000269|PubMed:23229899, ECO:0000269|PubMed:25608530}.


uniprotID: Q92508
geneSymbol: PIEZO1
length: 2521
go: ENSG00000103335;
name:
Piezo-type mechanosensitive ion channel component 1 (Membrane protein induced by beta-amyloid treatment) (Mib) (Protein FAM38A)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; integral component of membrane [GO:0016021]; lamellipodium membrane [GO:0031258]; plasma membrane [GO:0005886]; cation channel activity [GO:0005261]; mechanosensitive ion channel activity [GO:0008381]; cation transport [GO:0006812]; cellular response to mechanical stimulus [GO:0071260]; detection of mechanical stimulus [GO:0050982]; positive regulation of cell-cell adhesion mediated by integrin [GO:0033634]; positive regulation of integrin activation [GO:0033625]; regulation of membrane potential [GO:0042391]

snps:
rs755885744 rs200970763 rs202103485 rs201226914 rs587777765 rs587776990 rs587776989 rs587777764 rs587776991 rs587776987 rs869025601 rs587776988 rs577860843 rs749288233 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20016066}; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q0KL00}. Cell membrane {ECO:0000269|PubMed:22529292, ECO:0000269|PubMed:23479567}; Multi-pass membrane protein {ECO:0000305}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:25119035}. Note=In erythrocytes, located in the plasma membrane (PubMed:22529292, PubMed:23479567). Accumulates at the leading apical lamellipodia of endothelial cells in response to shear stress (PubMed:25119035). {ECO:0000269|PubMed:22529292, ECO:0000269|PubMed:23479567, ECO:0000269|PubMed:25119035}.


uniprotID: P22234
geneSymbol: PAICS
reactome: R-HSA-73817;
pdb: 2H31;
length: 425
go: ENSG00000128050;
drug: DB00128;
snps: rs11549976
name:
Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase); Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC)]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; 5-amino-4-imidazole carboxylate lyase activity [GO:0043727]; ATP binding [GO:0005524]; cadherin binding [GO:0045296]; identical protein binding [GO:0042802]; phosphoribosylaminoimidazole carboxylase activity [GO:0004638]; phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [GO:0004639]; 'de novo' IMP biosynthetic process [GO:0006189]; purine nucleobase biosynthetic process [GO:0009113]; purine ribonucleoside monophosphate biosynthetic process [GO:0009168]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P22234-1; Sequence=Displayed; Name=2; IsoId=P22234-2; Sequence=VSP_041265; 


uniprotID: O14986
geneSymbol: PIP5K1B
reactome: R-HSA-1660499;R-HSA-201688;R-HSA-6811558;
length: 540
go: ENSG00000107242;
snps: rs55897616
name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)

sequence:

opentargets:
cytosol [GO:0005829]; endomembrane system [GO:0012505]; membrane [GO:0016020]; uropod [GO:0001931]; 1-phosphatidylinositol-3-phosphate 4-kinase activity [GO:0052811]; 1-phosphatidylinositol-3-phosphate 5-kinase activity [GO:0000285]; 1-phosphatidylinositol-4-phosphate 5-kinase activity [GO:0016308]; 1-phosphatidylinositol-5-kinase activity [GO:0052810]; ATP binding [GO:0005524]; phosphatidylinositol-3,4-bisphosphate 5-kinase activity [GO:0052812]; phosphatidylinositol biosynthetic process [GO:0006661]; regulation of phosphatidylinositol 3-kinase signaling [GO:0014066]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O14986-1; Sequence=Displayed; Name=2; Synonyms=Isoform 1; IsoId=O14986-2; Sequence=VSP_016010, VSP_016011; Name=3; IsoId=O14986-3; Sequence=VSP_054771; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Note=Associated with membranes. {ECO:0000250}.


uniprotID: Q8WXW3
geneSymbol: PIBF1
name: Progesterone-induced-blocking factor 1 (PIBF) (Centrosomal protein of 90 kDa) (CEP90)
length: 757
go: ENSG00000083535;
snps: rs865883692 rs1372000 rs17089782 rs11544631 rs987735817
sequence:

opentargets:
centriolar satellite [GO:0034451]; centrosome [GO:0005813]; extracellular space [GO:0005615]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; interleukin-4 receptor binding [GO:0005136]; activation of Janus kinase activity [GO:0042976]; cilium assembly [GO:0060271]; immune system process [GO:0002376]; mitotic metaphase plate congression [GO:0007080]; mitotic spindle assembly [GO:0090307]; negative regulation of interleukin-12 production [GO:0032695]; negative regulation of natural killer cell activation [GO:0032815]; negative regulation of prostaglandin biosynthetic process [GO:0031393]; negative regulation of tyrosine phosphorylation of STAT protein [GO:0042532]; non-motile cilium assembly [GO:1905515]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of tyrosine phosphorylation of STAT protein [GO:0042531]; protein localization to centrosome [GO:0071539]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=90 kDa form; IsoId=Q8WXW3-1; Sequence=Displayed; Name=2; IsoId=Q8WXW3-2; Sequence=VSP_015302; Note=No experimental confirmation available.; Name=3; IsoId=Q8WXW3-3; Sequence=VSP_015303, VSP_015304; Note=No experimental confirmation available.; Name=4; Synonyms=34/35 kDa form; IsoId=Q8WXW3-4; Sequence=VSP_057956; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Cytoplasm {ECO:0000269|PubMed:25218441}. Secreted {ECO:0000269|PubMed:25218441}. Note=In progesterone-treated astrocytoma cells a 57 kDa protein and isoform 1 (90 kDa) have been described, both being located in the intracellular medium and secreted. Respective predominant forms are isoform 1 in the intracellular and the 57 kDa protein in the extracellular medium (PubMed:25218441). {ECO:0000269|PubMed:25218441}.; SUBCELLULAR LOCATION: Isoform 1: Nucleus {ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:25218441}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15305375}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:21224392, ECO:0000269|PubMed:26297806}. Secreted {ECO:0000269|PubMed:25218441}. Note=Localizes to centriolar satellites throughout the cell cycle. {ECO:0000269|PubMed:26297806}.; SUBCELLULAR LOCATION: Isoform 4: Secreted {ECO:0000269|PubMed:14634107, ECO:0000269|PubMed:3863495}. Note=Secreted by progesterone-treated lymphocytes (PubMed:14634107). {ECO:0000269|PubMed:14634107}.


uniprotID: Q5H8A4
geneSymbol: PIGG
reactome: R-HSA-162710;
length: 983
go: ENSG00000174227;
snps: rs34120878 rs13115344 rs7666425 rs372392424 rs13114026 rs34916638 rs34623004 rs1127410
name:
GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (GPI7 homolog) (hGPI7) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; membrane [GO:0016020]; CP2 mannose-ethanolamine phosphotransferase activity [GO:0051267]; phosphotransferase activity, for other substituted phosphate groups [GO:0016780]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q5H8A4-1; Sequence=Displayed; Name=2; IsoId=Q5H8A4-2; Sequence=VSP_019832; Note=No experimental confirmation available.; Name=3; IsoId=Q5H8A4-3; Sequence=VSP_019828; Note=No experimental confirmation available.; Name=4; IsoId=Q5H8A4-4; Sequence=VSP_019831, VSP_019833; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; IsoId=Q5H8A4-5; Sequence=VSP_019827, VSP_019829, VSP_019830; Note=No experimental confirmation available.; Name=6; IsoId=Q5H8A4-6; Sequence=VSP_054387, VSP_054388, VSP_019833; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15632136}; Multi-pass membrane protein {ECO:0000269|PubMed:15632136}.


uniprotID: P37287
geneSymbol: PIGA
reactome: R-HSA-162710;
length: 484
go: ENSG00000165195;
snps: rs34422225 rs587777398 rs587777400 rs587777396 rs201119959
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (EC 2.4.1.198) (GlcNAc-PI synthesis protein) (Phosphatidylinositol-glycan biosynthesis class A protein) (PIG-A)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; UDP-glycosyltransferase activity [GO:0008194]; cellular response to leukemia inhibitory factor [GO:1990830]; GPI anchor biosynthetic process [GO:0006506]; positive regulation of metabolic process [GO:0009893]; preassembly of GPI anchor in ER membrane [GO:0016254]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P37287-1; Sequence=Displayed; Name=2; IsoId=P37287-2; Sequence=VSP_001802; Name=3; IsoId=P37287-3; Sequence=VSP_043366, VSP_043367; Note=No experimental confirmation available.; 


uniprotID: Q92535
geneSymbol: PIGC
reactome: R-HSA-162710;
length: 297
go: ENSG00000135845;
snps: rs1063412
name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C (EC 2.4.1.198) (Phosphatidylinositol-glycan biosynthesis class C protein) (PIG-C)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; integral component of membrane [GO:0016021]; catalytic activity [GO:0003824]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; GPI anchor biosynthetic process [GO:0006506]; preassembly of GPI anchor in ER membrane [GO:0016254]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8806613}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q9BRB3
geneSymbol: PIGQ
reactome: R-HSA-162710;
length: 760
go: ENSG00000007541;
snps: rs2071979 rs1045277 rs710924 rs710925
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q (EC 2.4.1.198) (N-acetylglucosamyl transferase component GPI1) (Phosphatidylinositol-glycan biosynthesis class Q protein) (PIG-Q)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex [GO:0000506]; integral component of membrane [GO:0016021]; phosphatidylinositol N-acetylglucosaminyltransferase activity [GO:0017176]; carbohydrate metabolic process [GO:0005975]; preassembly of GPI anchor in ER membrane [GO:0016254]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BRB3-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9BRB3-2; Sequence=VSP_007281, VSP_007282; Name=3; IsoId=Q9BRB3-3; Sequence=VSP_007279, VSP_007280; Note=No experimental confirmation available.; 


uniprotID: Q9H307
geneSymbol: PNN
length: 717
go: ENSG00000100941;
snps: rs13021
name:
Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Desmosome-associated protein) (Domain-rich serine protein) (DRS protein) (DRSP) (Melanoma metastasis clone A protein) (Nuclear protein SDK3) (SR-like protein)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cell-cell junction [GO:0005911]; desmosome [GO:0030057]; exon-exon junction complex [GO:0035145]; intermediate filament [GO:0005882]; membrane [GO:0016020]; nuclear speck [GO:0016607]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; mRNA splicing, via spliceosome [GO:0000398]

location:
SUBCELLULAR LOCATION: Nucleus speckle. Cell junction, desmosome. Note=Cell-cell contact area, predominantly desmosome of intercellular adherens junction. Not a nucleocytoplasmic shuttling protein.


uniprotID: P12273
geneSymbol: PIP
reactome: R-HSA-5223345;
pdb: 3ES6;
length: 146
go: ENSG00000159763;
location: SUBCELLULAR LOCATION: Secreted.
name:
Prolactin-inducible protein (Gross cystic disease fluid protein 15) (GCDFP-15) (Prolactin-induced protein) (Secretory actin-binding protein) (SABP) (gp17)

sequence:
MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKNFDIPKSVRPNDEVTAVLAVQTELKECMVVKTYLISSIPLQGAFNYKYTACLCDDNPKTFYWDFYTNRTVQIAAVVDVIRELGICPDDAAVIPIKNNRFYTIEILKVE

opentargets:
extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; nucleus [GO:0005634]; actin binding [GO:0003779]; aspartic-type endopeptidase activity [GO:0004190]; IgG binding [GO:0019864]; protein dimerization activity [GO:0046983]; detection of chemical stimulus involved in sensory perception of bitter taste [GO:0001580]; negative regulation of T cell apoptotic process [GO:0070233]; positive regulation of gene expression [GO:0010628]; proteolysis [GO:0006508]; retina homeostasis [GO:0001895]; transmembrane transport [GO:0055085]


uniprotID: Q96BK5
geneSymbol: PINX1
length: 328
go: ENSG00000254093;
snps: rs35530857 rs17855458 rs17711777 rs1078543 rs34656824
name:
PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)

sequence:

opentargets:
chromosome, telomeric region [GO:0000781]; condensed chromosome kinetochore [GO:0000777]; kinetochore [GO:0000776]; nuclear chromosome [GO:0000228]; nuclear chromosome, telomeric region [GO:0000784]; nucleolus [GO:0005730]; spindle [GO:0005819]; protein-containing complex binding [GO:0044877]; telomerase inhibitor activity [GO:0010521]; telomerase RNA binding [GO:0070034]; mitotic metaphase plate congression [GO:0007080]; negative regulation of cell proliferation [GO:0008285]; negative regulation of G2/M transition of mitotic cell cycle [GO:0010972]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of telomerase activity [GO:0051974]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of protein localization to nucleolus [GO:1904751]; positive regulation of telomeric DNA binding [GO:1904744]; protein localization to chromosome, telomeric region [GO:0070198]; protein localization to nucleolus [GO:1902570]; regulation of protein stability [GO:0031647]; regulation of telomerase activity [GO:0051972]; telomere maintenance via telomerase [GO:0007004]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96BK5-1; Sequence=Displayed; Name=2; Synonyms=PINY1; IsoId=Q96BK5-2; Sequence=VSP_003945, VSP_003946; 

location:
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Note=Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.


uniprotID: Q99697
geneSymbol: PITX2
reactome: R-HSA-8866906;
pdb: 2L7F;2L7M;2LKX;
length: 317
go: ENSG00000164093;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; phosphoprotein binding [GO:0051219]; protein homodimerization activity [GO:0042803]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; ribonucleoprotein complex binding [GO:0043021]; RNA polymerase II activating transcription factor binding [GO:0001102]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; sequence-specific DNA binding [GO:0043565]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; anatomical structure morphogenesis [GO:0009653]; camera-type eye development [GO:0043010]; cardiac neural crest cell migration involved in outflow tract morphogenesis [GO:0003253]; cell proliferation involved in outflow tract morphogenesis [GO:0061325]; deltoid tuberosity development [GO:0035993]; determination of left/right symmetry [GO:0007368]; hair cell differentiation [GO:0035315]; iris morphogenesis [GO:0061072]; left/right axis specification [GO:0070986]; negative regulation of transcription by RNA polymerase II [GO:0000122]; odontogenesis [GO:0042476]; positive regulation of transcription by RNA polymerase II [GO:0045944]; prolactin secreting cell differentiation [GO:0060127]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]; somatotropin secreting cell differentiation [GO:0060126]; spleen development [GO:0048536]

snps:
rs104893857 rs104893862 rs1057519484 rs104893858 rs104893861 rs121909249 rs121909248 rs387906810 rs104893859 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=PTX2B; Synonyms=ARP1B; IsoId=Q99697-1; Sequence=Displayed; Name=PTX2C; Synonyms=ARP1C; IsoId=Q99697-2; Sequence=VSP_002260; Name=PTX2A; Synonyms=ARP1A; IsoId=Q99697-3; Sequence=VSP_002261; 


uniprotID: Q7Z443
geneSymbol: PKD1L3
name: Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein) (Polycystin-1L3)
length: 1732
go: ENSG00000277481;
sequence:

opentargets:
cation channel complex [GO:0034703]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; cation transport [GO:0006812]; cellular response to acidic pH [GO:0071468]; detection of chemical stimulus involved in sensory perception of sour taste [GO:0001581]; detection of mechanical stimulus [GO:0050982]; kidney development [GO:0001822]; sensory perception of sour taste [GO:0050915]

snps:
rs16973585 rs4788591 rs12708923 rs7185272 rs16973537 rs1559401 rs9925415 rs9921412 rs1035543 rs13335617 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:23212381}; Multi-pass membrane protein {ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:23212381}. Note=Interaction with PKD2L1 is required for localization to the cell membrane.


uniprotID: P42338
geneSymbol: PIK3CB
length: 1070
go: ENSG00000051382;
drug: DB00201;DB05241;
snps: rs2230462
reactome:
R-HSA-109704;R-HSA-112399;R-HSA-114604;R-HSA-1257604;R-HSA-1660499;R-HSA-186763;R-HSA-198203;R-HSA-202424;R-HSA-2029485;R-HSA-210993;R-HSA-2219530;R-HSA-2424491;R-HSA-2730905;R-HSA-373753;R-HSA-4420097;R-HSA-512988;R-HSA-6811558;R-HSA-8853659;R-HSA-912526;R-HSA-912631;

name:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PI3-kinase subunit beta) (PI3K-beta) (PI3Kbeta) (PtdIns-3-kinase subunit beta) (EC 2.7.1.153) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta) (PtdIns-3-kinase subunit p110-beta) (p110beta)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; midbody [GO:0030496]; nucleolus [GO:0005730]; nucleus [GO:0005634]; phosphatidylinositol 3-kinase complex [GO:0005942]; plasma membrane [GO:0005886]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; 1-phosphatidylinositol-4-phosphate 3-kinase activity [GO:0035005]; ATP binding [GO:0005524]; insulin receptor substrate binding [GO:0043560]; kinase activity [GO:0016301]; phosphatidylinositol 3-kinase activity [GO:0035004]; phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934]; activation of MAPK activity [GO:0000187]; angiogenesis involved in wound healing [GO:0060055]; autophagy [GO:0006914]; axon guidance [GO:0007411]; cell migration [GO:0016477]; cellular calcium ion homeostasis [GO:0006874]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; embryonic cleavage [GO:0040016]; endothelial cell proliferation [GO:0001935]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; leukocyte migration [GO:0050900]; phosphatidylinositol 3-kinase signaling [GO:0014065]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; phosphorylation [GO:0016310]; platelet activation [GO:0030168]; platelet aggregation [GO:0070527]; positive regulation of autophagy [GO:0010508]; positive regulation of gene expression [GO:0010628]; positive regulation of neutrophil apoptotic process [GO:0033031]; positive regulation of protein kinase B signaling [GO:0051897]; protein phosphorylation [GO:0006468]; regulation of cell-matrix adhesion [GO:0001952]; regulation of clathrin-dependent endocytosis [GO:2000369]; signal transduction [GO:0007165]; T cell receptor signaling pathway [GO:0050852]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383062}. Nucleus {ECO:0000269|PubMed:21383062}. Note=Interaction with PIK3R2 is required for nuclear localization and export.


uniprotID: Q8NEB9
geneSymbol: PIK3C3
reactome: R-HSA-109704;R-HSA-1632852;R-HSA-1660514;R-HSA-1660516;R-HSA-1660517;R-HSA-168138;R-HSA-5668599;
pdb: 3IHY;3LS8;4OYS;4PH4;4UWF;4UWG;4UWH;4UWK;4UWL;5ANL;5ENN;
length: 887
go: ENSG00000078142;
drug: DB06836;
name:
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)

sequence:

opentargets:
autolysosome [GO:0044754]; axoneme [GO:0005930]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; late endosome [GO:0005770]; membrane [GO:0016020]; midbody [GO:0030496]; peroxisome [GO:0005777]; phagocytic vesicle membrane [GO:0030670]; phagophore assembly site [GO:0000407]; phosphatidylinositol 3-kinase complex, class III [GO:0035032]; phosphatidylinositol 3-kinase complex, class III, type I [GO:0034271]; phosphatidylinositol 3-kinase complex, class III, type II [GO:0034272]; 1-phosphatidylinositol-3-kinase activity [GO:0016303]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; protein kinase activity [GO:0004672]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of peroxisome [GO:0030242]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to glucose starvation [GO:0042149]; early endosome to late endosome transport [GO:0045022]; endocytosis [GO:0006897]; endosome organization [GO:0007032]; macroautophagy [GO:0016236]; phosphatidylinositol phosphorylation [GO:0046854]; phosphatidylinositol-3-phosphate biosynthetic process [GO:0036092]; phosphatidylinositol-mediated signaling [GO:0048015]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]; protein phosphorylation [GO:0006468]; protein processing [GO:0016485]; regulation of cytokinesis [GO:0032465]; regulation of protein secretion [GO:0050708]; response to leucine [GO:0043201]; toll-like receptor 9 signaling pathway [GO:0034162]

location:
SUBCELLULAR LOCATION: Midbody {ECO:0000269|PubMed:20208530}. Late endosome {ECO:0000269|PubMed:14617358}. Cytoplasmic vesicle, autophagosome {ECO:0000305|PubMed:14617358}. Note=As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (Probable). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q6PF93, ECO:0000305|PubMed:14617358}.


uniprotID: Q9HB19
geneSymbol: PLEKHA2
reactome: R-HSA-1660499;
length: 425
snps: rs59439576
name:
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)

sequence:

opentargets:
cytoplasm [GO:0005737]; membrane [GO:0016020]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; fibronectin binding [GO:0001968]; laminin binding [GO:0043236]; PDZ domain binding [GO:0030165]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol biosynthetic process [GO:0006661]; positive regulation of cell-matrix adhesion [GO:0001954]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000250}.


uniprotID: P98161
geneSymbol: PKD1
reactome: R-HSA-5620916;
pdb: 1B4R;6A70;
name: Polycystin-1 (PC1) (Autosomal dominant polycystic kidney disease 1 protein)
length: 4303
go: ENSG00000008710;
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; cell surface [GO:0009986]; ciliary membrane [GO:0060170]; cilium [GO:0005929]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; Golgi membrane [GO:0000139]; Golgi-associated vesicle membrane [GO:0030660]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; lateral plasma membrane [GO:0016328]; motile cilium [GO:0031514]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; polycystin complex [GO:0002133]; calcium channel activity [GO:0005262]; carbohydrate binding [GO:0030246]; ion channel binding [GO:0044325]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; anatomical structure morphogenesis [GO:0009653]; branching morphogenesis of an epithelial tube [GO:0048754]; calcium ion transmembrane transport [GO:0070588]; calcium-independent cell-matrix adhesion [GO:0007161]; cartilage condensation [GO:0001502]; cartilage development [GO:0051216]; cell cycle arrest [GO:0007050]; cell-matrix adhesion [GO:0007160]; cytoplasmic sequestering of transcription factor [GO:0042994]; detection of mechanical stimulus [GO:0050982]; digestive tract development [GO:0048565]; embryonic placenta development [GO:0001892]; establishment of cell polarity [GO:0030010]; genitalia development [GO:0048806]; heart development [GO:0007507]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; in utero embryonic development [GO:0001701]; JAK-STAT cascade [GO:0007259]; kidney development [GO:0001822]; liver development [GO:0001889]; lung epithelium development [GO:0060428]; lymph vessel morphogenesis [GO:0036303]; mesonephric duct development [GO:0072177]; mesonephric tubule development [GO:0072164]; metanephric ascending thin limb development [GO:0072218]; metanephric collecting duct development [GO:0072205]; metanephric distal tubule morphogenesis [GO:0072287]; metanephric proximal tubule development [GO:0072237]; neural tube development [GO:0021915]; peptidyl-serine phosphorylation [GO:0018105]; placenta blood vessel development [GO:0060674]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of protein binding [GO:0032092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein export from nucleus [GO:0006611]; regulation of cell adhesion [GO:0030155]; regulation of mitotic spindle organization [GO:0060236]; regulation of proteasomal protein catabolic process [GO:0061136]; response to fluid shear stress [GO:0034405]; skin development [GO:0043588]; spinal cord development [GO:0021510]

snps:
rs560049593 rs886038369 rs958271752 rs199476099 rs58598099 rs149022148 rs1616940 rs40433 rs199476100 rs2369063 rs1266492292 rs2549677 rs241573 rs573566419 rs146887330 rs1033550407 rs143690392 rs116092985 rs148164067 rs241572 rs761106434 rs139520275 rs241571 rs151176070 rs778028644 rs144137200 rs754890213 rs137978188 rs752388015 rs1383930225 rs140869992 rs139971481 rs200433577 rs538769374 rs151257298 rs2432404 rs3874655 rs200037070 rs28369051 rs758896945 rs2432405 rs778565182 rs9936785 rs374500158 rs144557371 rs201238819 rs147350387 rs150568356 rs141717814 rs1800569 rs1800568 rs144979397 rs1057518897 rs151089809 rs367746233 rs534112936 rs149151043 rs755522953 rs752447240 rs147788838 rs750780241 rs13337123 rs150189496 rs373952574 rs1063401 rs117896488 rs17135779 rs200522524 rs778055216 rs9925969 rs139945204 rs140791671 rs201780393 rs781263445 rs371283948 rs776463508 rs140189010 rs45478794 rs141946034 rs34197769 rs79000340 rs781492044 rs1327414405 rs142768096 rs10960 rs3209986 rs148478410 rs115538130 rs547854563 rs114251396 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P98161-1; Sequence=Displayed; Name=2; IsoId=P98161-2; Sequence=VSP_009677, VSP_009678; Name=3; IsoId=P98161-3; Sequence=VSP_009678; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:20980620, ECO:0000269|PubMed:27259053}; Multi-pass membrane protein {ECO:0000269|PubMed:20980620}. Cell projection, cilium {ECO:0000250|UniProtKB:O08852}. Note=PKD1 localization to the plasma and ciliary membranes requires PKD2, is independent of PKD2 channel activity, and involves stimulation of PKD1 autoproteolytic cleavage at the GPS domain (By similarity). Ciliary localization of PKD1 requires BBS1 and ARL6/BBS3 (By similarity). Cell surface localization requires GANAB (PubMed:27259053). {ECO:0000250|UniProtKB:O08852, ECO:0000269|PubMed:27259053}.


