# annotation

uniprotID: Q9H6F2
geneSymbol: TMEM38A
name: Trimeric intracellular cation channel type A (TRIC-A) (TRICA) (Transmembrane protein 38A)
length: 299
go: ENSG00000072954;
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; nuclear membrane [GO:0031965]; sarcoplasmic reticulum membrane [GO:0033017]; potassium channel activity [GO:0005267]

location:
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:A5A6S6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A5A6S6}. Nucleus membrane {ECO:0000250|UniProtKB:A5A6S6}.


uniprotID: Q96AN5
geneSymbol: TMEM143
name: Transmembrane protein 143
length: 459
go: ENSG00000161558;
opentargets: integral component of membrane [GO:0016021]; mitochondrion [GO:0005739]
snps: rs34488893
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96AN5-1; Sequence=Displayed; Name=2; IsoId=Q96AN5-2; Sequence=VSP_024930; Name=3; IsoId=Q96AN5-3; Sequence=VSP_024931, VSP_024932; 


uniprotID: Q7Z5S9
geneSymbol: TMEM144
name: Transmembrane protein 144
length: 345
go: ENSG00000164124;
snps: rs34277853
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; carbohydrate transmembrane transporter activity [GO:0015144]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z5S9-1; Sequence=Displayed; Name=2; IsoId=Q7Z5S9-2; Sequence=VSP_025850, VSP_025851; Note=No experimental confirmation available.; 


uniprotID: A0PJW6
geneSymbol: TMEM223
name: Transmembrane protein 223
length: 202
go: ENSG00000168569;
opentargets: integral component of membrane [GO:0016021]; nervous system development [GO:0007399]
snps: rs2584918 rs11827177
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: E9PQX1
geneSymbol: TMEM262
name: Transmembrane protein 262
length: 116
go: ENSG00000187066;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MWLQDRIATFFFPKGMMLTTAALMLFFLHLGIFIRDVHNFCITYHYDHMSFHYTVVLMFSQVISICWAAMGSLYAEMTENKYVCFSALTILMLNGAMFFNRLSLEFLAIEYREEHH


uniprotID: A6NDV4
geneSymbol: TMEM8B
length: 472
go: ENSG00000137103;
name:
Transmembrane protein 8B (Nasopharyngeal carcinoma-associated gene 6 protein) (Protein NAG-5) (Protein NGX6)

sequence:

opentargets:
cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cell-matrix adhesion [GO:0007160]; regulation of growth [GO:0040008]; regulation of mitotic cell cycle [GO:0007346]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A6NDV4-1; Sequence=Displayed; Name=2; IsoId=A6NDV4-2; Sequence=VSP_033452, VSP_033453; Name=3; IsoId=A6NDV4-3; Sequence=VSP_033450, VSP_033451, VSP_033452, VSP_033453; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000269|PubMed:17641538}; Multi-pass membrane protein {ECO:0000269|PubMed:17641538}. Cytoplasm {ECO:0000269|PubMed:17641538}. Nucleus {ECO:0000269|PubMed:17641538}. Mitochondrion {ECO:0000269|PubMed:17641538}. Endoplasmic reticulum {ECO:0000269|PubMed:17641538}. Note=Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538).


uniprotID: A6NFA1
geneSymbol: TRABD2B
length: 517
go: ENSG00000269113;
name:
Metalloprotease TIKI2 (EC 3.4.-.-) (Heart, kidney and adipose-enriched transmembrane protein homolog) (TRAB domain-containing protein 2B)

sequence:

opentargets:
integral component of organelle membrane [GO:0031301]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; metal ion binding [GO:0046872]; metalloendopeptidase activity [GO:0004222]; Wnt-protein binding [GO:0017147]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of protein oligomerization [GO:0032461]; positive regulation of protein oxidation [GO:1904808]; proteolysis [GO:0006508]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726442}; Single-pass type I membrane protein {ECO:0000269|PubMed:22726442}.


uniprotID: P01033
geneSymbol: TIMP1
reactome: R-HSA-114608;R-HSA-1592389;R-HSA-381426;R-HSA-6783783;R-HSA-6785807;R-HSA-8957275;
pdb: 1D2B;1LQN;1OO9;1UEA;2J0T;3MA2;3V96;
length: 207
go: ENSG00000102265;
name:
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)

sequence:

opentargets:
basement membrane [GO:0005604]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; platelet alpha granule lumen [GO:0031093]; cytokine activity [GO:0005125]; growth factor activity [GO:0008083]; metalloendopeptidase inhibitor activity [GO:0008191]; peptidase inhibitor activity [GO:0030414]; protease binding [GO:0002020]; zinc ion binding [GO:0008270]; aging [GO:0007568]; cartilage development [GO:0051216]; cell activation [GO:0001775]; cellular protein metabolic process [GO:0044267]; connective tissue replacement involved in inflammatory response wound healing [GO:0002248]; cytokine-mediated signaling pathway [GO:0019221]; extracellular matrix disassembly [GO:0022617]; negative regulation of apoptotic process [GO:0043066]; negative regulation of catalytic activity [GO:0043086]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of metallopeptidase activity [GO:1905049]; negative regulation of trophoblast cell migration [GO:1901164]; platelet degranulation [GO:0002576]; positive regulation of cell proliferation [GO:0008284]; post-translational protein modification [GO:0043687]; regulation of integrin-mediated signaling pathway [GO:2001044]; response to cytokine [GO:0034097]; response to hormone [GO:0009725]; response to organic substance [GO:0010033]; response to peptide hormone [GO:0043434]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.


uniprotID: Q86XT9
geneSymbol: TMEM219
reactome: R-HSA-6803211;
name: Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219)
length: 240
go: ENSG00000149932;
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]; regulation of apoptotic process [GO:0042981]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20353938}; Single-pass membrane protein {ECO:0000269|PubMed:20353938}.


uniprotID: Q9NYK1
geneSymbol: TLR7
reactome: R-HSA-1679131;R-HSA-168181;R-HSA-975110;R-HSA-975138;R-HSA-975155;
name: Toll-like receptor 7
length: 1049
go: ENSG00000196664;
drug: DB05127;DB01611;DB00724;DB04860;DB05475;
snps: rs179008 rs5743781
sequence:

opentargets:
cytoplasm [GO:0005737]; early phagosome [GO:0032009]; endolysosome membrane [GO:0036020]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; endosome membrane [GO:0010008]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; double-stranded RNA binding [GO:0003725]; drug binding [GO:0008144]; signaling pattern recognition receptor activity [GO:0008329]; single-stranded RNA binding [GO:0003727]; siRNA binding [GO:0035197]; transmembrane signaling receptor activity [GO:0004888]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of chemokine production [GO:0032722]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha biosynthetic process [GO:0045356]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; regulation of protein phosphorylation [GO:0001932]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P58681}. Endosome {ECO:0000250|UniProtKB:P58681}. Lysosome {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250|UniProtKB:P58681}.


uniprotID: O14925
geneSymbol: TIMM23
reactome: R-HSA-1268020;
name: Mitochondrial import inner membrane translocase subunit Tim23
length: 209
go: ENSG00000265354;
sequence:

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein transmembrane transporter activity [GO:0008320]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q8WW34
geneSymbol: TMEM239
name: Transmembrane protein 239
length: 195
go: ENSG00000198326;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MRVGTWICLPGRPGRCRKQHDLGNCPEVPGIFKTLALSPGAPDMMQQPRVETDTIGAGEGPQQAVPWSAWVTRHGWVRWWVSHMPPSWIQWWSTSNWRQPLQRLLWGLEGILYLLLALMLCHALFTTGSHLLSSLWPVVAAVWRHLLPALLLLVLSALPALLFTASFLLLFSTLLSLVGLLTSMTHPGDTQDLDQ

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WW34-1; Sequence=Displayed; Name=2; IsoId=Q8WW34-2; Sequence=VSP_053737; Note=No experimental confirmation available.; 


uniprotID: Q9BXS4
geneSymbol: TMEM59
name: Transmembrane protein 59 (Liver membrane-bound protein)
length: 323
go: ENSG00000116209;
snps: rs41294776
sequence:

opentargets:
extracellular exosome [GO:0070062]; Golgi cis cisterna [GO:0000137]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; integral component of membrane [GO:0016021]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; endopeptidase activity [GO:0004175]; autophagy [GO:0006914]; negative regulation of protein glycosylation in Golgi [GO:0090285]; negative regulation of protein localization to plasma membrane [GO:1903077]; negative regulation of protein processing [GO:0010955]; positive regulation of autophagy [GO:0010508]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23376921}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20427278}; Single-pass type I membrane protein {ECO:0000255}. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. {ECO:0000269|PubMed:23376921}.


uniprotID: Q15399
geneSymbol: TLR1
reactome: R-HSA-1236974;R-HSA-1461957;R-HSA-166058;R-HSA-168179;R-HSA-5602498;R-HSA-5603041;R-HSA-5686938;
pdb: 1FYV;2Z7X;
name: Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
length: 786
go: ENSG00000174125;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; membrane raft [GO:0045121]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; Toll-like receptor 1-Toll-like receptor 2 protein complex [GO:0035354]; identical protein binding [GO:0042802]; lipopeptide binding [GO:0071723]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; Toll-like receptor 2 binding [GO:0035663]; transmembrane signaling receptor activity [GO:0004888]; cell activation [GO:0001775]; cellular response to triacyl bacterial lipopeptide [GO:0071727]; detection of triacyl bacterial lipopeptide [GO:0042495]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of interleukin-6 biosynthetic process [GO:0045410]; positive regulation of interleukin-8 secretion [GO:2000484]; positive regulation of toll-like receptor 2 signaling pathway [GO:0034137]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; signal transduction [GO:0007165]; toll-like receptor 1 signaling pathway [GO:0034130]; toll-like receptor signaling pathway [GO:0002224]; toll-like receptor TLR1:TLR2 signaling pathway [GO:0038123]

snps:
rs76600635 rs137853170 rs5743611 rs5743612 rs4833095 rs3923647 rs5743613 rs76796448 rs137853171 rs137853172 rs137853173 rs5743617 rs5743618 rs5743619 rs137853174 rs113706342 rs5743621 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16880211}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9EPQ1}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000269|PubMed:16880211}.


uniprotID: Q96B77
geneSymbol: TMEM186
name: Transmembrane protein 186
length: 213
go: ENSG00000184857;
opentargets: integral component of membrane [GO:0016021]; mitochondrion [GO:0005739]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: A0AVI4
geneSymbol: TMEM129
reactome: R-HSA-8866654;
name: E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129)
length: 362
go: ENSG00000168936;
snps: rs798752
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to unfolded protein [GO:0006986]; retrograde protein transport, ER to cytosol [GO:0030970]; ubiquitin-dependent ERAD pathway [GO:0030433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A0AVI4-1; Sequence=Displayed; Name=2; IsoId=A0AVI4-2; Sequence=VSP_036641, VSP_036642; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24807418}; Multi-pass membrane protein {ECO:0000269|PubMed:24807418}.


uniprotID: Q24JQ0
geneSymbol: TMEM241
name: Transmembrane protein 241
length: 296
go: ENSG00000134490;
opentargets: integral component of membrane [GO:0016021]
snps: rs8099409
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q24JQ0-1; Sequence=Displayed; Name=2; IsoId=Q24JQ0-2; Sequence=VSP_028706, VSP_028708; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q24JQ0-3; Sequence=VSP_028704, VSP_028705, VSP_028707; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: O15321
geneSymbol: TM9SF1
name: Transmembrane 9 superfamily member 1 (MP70 protein family member) (hMP70)
length: 606
go: ENSG00000100926;
snps: rs11549700 rs10583
sequence:

opentargets:
autophagosome membrane [GO:0000421]; cytoplasmic vesicle [GO:0031410]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; autophagy [GO:0006914]; protein localization to membrane [GO:0072657]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15321-1; Sequence=Displayed; Name=2; IsoId=O15321-2; Sequence=VSP_042781; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:19029833}; Multi-pass membrane protein {ECO:0000269|PubMed:19029833}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19029833}; Multi-pass membrane protein {ECO:0000269|PubMed:19029833}.


uniprotID: Q9BQ16
geneSymbol: SPOCK3
reactome: R-HSA-1592389;
name: Testican-3 (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3)
length: 436
go: ENSG00000196104;
snps: rs9685645
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; glycosaminoglycan binding [GO:0005539]; metalloendopeptidase inhibitor activity [GO:0008191]; negative regulation of cell motility [GO:2000146]; negative regulation of endopeptidase activity [GO:0010951]; peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan [GO:0019800]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Name=3; IsoId=Q9BQ16-3; Sequence=Displayed; Name=1; IsoId=Q9BQ16-1; Sequence=VSP_013598; Name=2; Synonyms=N-tes; IsoId=Q9BQ16-2; Sequence=VSP_005334, VSP_005335; Name=4; IsoId=Q9BQ16-4; Sequence=VSP_043681; Note=No experimental confirmation available.; Name=5; IsoId=Q9BQ16-5; Sequence=VSP_045104; Name=6; IsoId=Q9BQ16-6; Sequence=VSP_045899, VSP_045900; Note=No experimental confirmation available.; Name=7; IsoId=Q9BQ16-7; Sequence=VSP_046686; Name=8; IsoId=Q9BQ16-8; Sequence=VSP_013598, VSP_046687; Note=No experimental confirmation available.; Name=9; IsoId=Q9BQ16-9; Sequence=VSP_013598, VSP_005334, VSP_005335; Note=No experimental confirmation available.; 


uniprotID: Q96SK2
geneSymbol: TMEM209
name: Transmembrane protein 209
length: 561
go: ENSG00000146842;
opentargets: integral component of membrane [GO:0016021]
snps: rs17857472 rs17854938
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96SK2-1; Sequence=Displayed; Name=2; IsoId=Q96SK2-2; Sequence=VSP_033280; Name=3; IsoId=Q96SK2-3; Sequence=VSP_033283; Note=No experimental confirmation available.; Name=4; IsoId=Q96SK2-4; Sequence=VSP_033281, VSP_033282; Note=No experimental confirmation available.; 


uniprotID: Q8TDI7
geneSymbol: TMC2
name: Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2)
length: 906
go: ENSG00000149488;
snps: rs6050063 rs11908093 rs34884202 rs16987592 rs16987592 rs768537423 rs6115242
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; stereocilium tip [GO:0032426]; ion channel activity [GO:0005216]; mechanosensitive ion channel activity [GO:0008381]; voltage-gated calcium channel activity [GO:0005245]; detection of mechanical stimulus involved in sensory perception of sound [GO:0050910]; regulation of calcium ion transmembrane transport [GO:1903169]; vestibular reflex [GO:0060005]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TDI7-1; Sequence=Displayed; Name=2; IsoId=Q8TDI7-3; Sequence=VSP_015281, VSP_015282; Note=No experimental confirmation available.; Name=3; IsoId=Q8TDI7-4; Sequence=VSP_015279, VSP_015283, VSP_015284; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E7FFT2}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the stereocilia of the cochlear hair cells. {ECO:0000250|UniProtKB:Q8R4P4}.


uniprotID: Q9BSF4
geneSymbol: TIMM29
name: Mitochondrial import inner membrane translocase subunit Tim29 (TIM29)
length: 260
go: ENSG00000142444;
sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; protein import into mitochondrial inner membrane [GO:0045039]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27554484, ECO:0000269|PubMed:27718247}; Single-pass membrane protein {ECO:0000305}; Intermembrane side {ECO:0000269|PubMed:27718247}.


uniprotID: Q9BSI4
geneSymbol: TINF2
reactome: R-HSA-1221632;R-HSA-171306;R-HSA-2559586;
pdb: 3BQO;3BU8;5XYF;
name: TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2)
length: 451
go: ENSG00000092330;
snps: rs35653076 rs17102313 rs17102311 rs121918543 rs121918544 rs121918545
sequence:

opentargets:
chromosome, telomeric region [GO:0000781]; nuclear body [GO:0016604]; nuclear chromosome, telomeric region [GO:0000784]; nuclear matrix [GO:0016363]; nuclear telomere cap complex [GO:0000783]; nucleoplasm [GO:0005654]; perinucleolar chromocenter [GO:0010370]; shelterin complex [GO:0070187]; telomeric DNA binding [GO:0042162]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of protein ADP-ribosylation [GO:0010836]; negative regulation of telomere maintenance via telomerase [GO:0032211]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of telomere maintenance via telomere lengthening [GO:1904356]; telomere assembly [GO:0032202]; telomere capping [GO:0016233]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=TIN2L; IsoId=Q9BSI4-1; Sequence=Displayed; Name=2; Synonyms=TIN2S; IsoId=Q9BSI4-2; Sequence=VSP_003989; Name=3; IsoId=Q9BSI4-3; Sequence=VSP_003987, VSP_003988; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19279399}. Chromosome, telomere {ECO:0000269|PubMed:19279399}. Note=Associated with telomeres.; SUBCELLULAR LOCATION: Isoform 1: Nucleus matrix {ECO:0000269|PubMed:19229133}.


uniprotID: Q03169
geneSymbol: TNFAIP2
length: 654
go: ENSG00000185215;
snps: rs1132339 rs2229727 rs2234146
name:
Tumor necrosis factor alpha-induced protein 2 (TNF alpha-induced protein 2) (Primary response gene B94 protein)

sequence:

opentargets:
exocyst [GO:0000145]; extracellular space [GO:0005615]; SNARE binding [GO:0000149]; angiogenesis [GO:0001525]; cell differentiation [GO:0030154]; exocyst localization [GO:0051601]; exocytosis [GO:0006887]


uniprotID: Q9NR97
geneSymbol: TLR8
reactome: R-HSA-1679131;R-HSA-168181;R-HSA-975110;R-HSA-975138;R-HSA-975155;
name: Toll-like receptor 8 (CD antigen CD288)
length: 1041
go: ENSG00000101916;
drug: DB00724;
snps: rs5744077 rs5744082
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
pdb:
3W3G;3W3J;3W3K;3W3L;3W3M;3W3N;3WN4;4QBZ;4QC0;4R07;4R08;4R09;4R0A;4R6A;5AWA;5AWB;5AWC;5AWD;5AZ5;5HDH;5WYX;5WYZ;5Z14;5Z15;

sequence:

opentargets:
endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; drug binding [GO:0008144]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; signaling pattern recognition receptor activity [GO:0008329]; signaling receptor activity [GO:0038023]; single-stranded RNA binding [GO:0003727]; transmembrane signaling receptor activity [GO:0004888]; cellular response to mechanical stimulus [GO:0071260]; defense response to virus [GO:0051607]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; immune response [GO:0006955]; immunoglobulin mediated immune response [GO:0016064]; innate immune response [GO:0045087]; microglial cell activation [GO:0001774]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of interleukin-12 secretion [GO:2001183]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-alpha biosynthetic process [GO:0045356]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-6 secretion [GO:2000778]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; regulation of protein phosphorylation [GO:0001932]; response to virus [GO:0009615]; toll-like receptor 8 signaling pathway [GO:0034158]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NR97-1; Sequence=Displayed; Name=2; IsoId=Q9NR97-2; Sequence=VSP_053412; 


uniprotID: Q5SV17
geneSymbol: TMEM240
name: Transmembrane protein 240
length: 173
go: ENSG00000205090;
snps: rs606231454 rs606231453 rs546291208 rs606231451 rs606231455
sequence:
MSMSANTMIFMILGASVVMAIACLMDMNALLDRFHNYILPHLRGEDRVCHCNCGRHHIHYVIPYDGDQSVVDASENYFVTDSVTKQEIDLMLGLLLGFCISWFLVWMDGVLHCAVRAWRAGRRYDGSWTWLPKLCSLRELGRRPHRPFEEAAGNMVHVKQKLYHNGHPSPRHL

opentargets:
cell junction [GO:0030054]; integral component of membrane [GO:0016021]; synaptic membrane [GO:0097060]

location:
SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250|UniProtKB:B2RWJ3}. Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q8NCS4
geneSymbol: TMEM35B
name: Transmembrane protein 35B (ZMYM6 neighbor protein)
length: 154
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MALLLSVLRVLLGGFFALVGLAKLSEEISAPVSERMNALFVQFAEVFPLKVFGYQPDPLNYQIAVGFLELLAGLLLVMGPPMLQEISNLFLILLMMGAIFTLAALKESLSTCIPAIVCLGFLLLLNVGQLLAQTKKVVRPTRKKTLSTFKESWK


uniprotID: Q9BVW5
geneSymbol: TIPIN
reactome: R-HSA-5693607;
name: TIMELESS-interacting protein
length: 301
go: ENSG00000075131;
snps: rs9806123 rs2063690 rs3759787 rs3759786 rs34848112 rs780014564
sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear chromatin [GO:0000790]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; DNA binding [GO:0003677]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; DNA replication checkpoint [GO:0000076]; intra-S DNA damage checkpoint [GO:0031573]; positive regulation of cell proliferation [GO:0008284]; regulation of nuclear cell cycle DNA replication [GO:0033262]; replication fork arrest [GO:0043111]; replication fork protection [GO:0048478]; response to UV [GO:0009411]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17141802}. Nucleus {ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17141802}.


uniprotID: Q9NX78
geneSymbol: TMEM260
name: Transmembrane protein 260
length: 707
go: ENSG00000070269;
opentargets: integral component of membrane [GO:0016021]
snps: rs17776256 rs1041316
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Long; IsoId=Q9NX78-1; Sequence=Displayed; Name=2; IsoId=Q9NX78-2; Sequence=VSP_008621; Note=No experimental confirmation available.; Name=3; Synonyms=Short; IsoId=Q9NX78-3; Sequence=VSP_058993, VSP_058994; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 1: Membrane {ECO:0000269|PubMed:28318500}. Note=Shows strong localization in the vicinity of the cell membrane. {ECO:0000269|PubMed:28318500}.; SUBCELLULAR LOCATION: Isoform 3: Membrane {ECO:0000269|PubMed:28318500}. Note=Shows perinuclear localization. {ECO:0000269|PubMed:28318500}.


uniprotID: Q8WVE6
geneSymbol: TMEM171
name: Transmembrane protein 171
length: 324
go: ENSG00000157111;
opentargets: integral component of membrane [GO:0016021]
snps: rs638333 rs637450 rs636926
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WVE6-1; Sequence=Displayed; Name=2; IsoId=Q8WVE6-2; Sequence=VSP_020520; Note=No experimental confirmation available.; 


uniprotID: Q99727
geneSymbol: TIMP4
name: Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)
length: 224
go: ENSG00000157150;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; sarcomere [GO:0030017]; metal ion binding [GO:0046872]; metalloendopeptidase inhibitor activity [GO:0008191]; protease binding [GO:0002020]; central nervous system development [GO:0007417]; negative regulation of endopeptidase activity [GO:0010951]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; Notch signaling pathway [GO:0007219]; ovulation cycle [GO:0042698]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; response to organic substance [GO:0010033]; response to peptide hormone [GO:0043434]


uniprotID: Q5T4D3
geneSymbol: TMTC4
name: Transmembrane and TPR repeat-containing protein 4
length: 741
go: ENSG00000125247;
opentargets: integral component of membrane [GO:0016021]
snps: rs3809371 rs946837 rs144940475
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5T4D3-1; Sequence=Displayed; Name=2; IsoId=Q5T4D3-2; Sequence=VSP_023622, VSP_023623; Note=No experimental confirmation available.; Name=3; IsoId=Q5T4D3-3; Sequence=VSP_038261; Note=No experimental confirmation available.; Name=4; IsoId=Q5T4D3-4; Sequence=VSP_054873; Note=No experimental confirmation available.; 


uniprotID: Q9H2K2
geneSymbol: TNKS2
reactome: R-HSA-201681;R-HSA-4641257;R-HSA-5545619;R-HSA-5689880;R-HSA-8948751;
length: 1166
go: ENSG00000107854;
pdb:
2Y0I;3KR7;3KR8;3MHJ;3MHK;3P0N;3P0P;3P0Q;3TWQ;3TWR;3TWS;3TWT;3TWU;3TWV;3TWW;3TWX;3U9H;3U9Y;3UA9;3W51;4AVU;4AVW;4BFP;4BJ9;4BJB;4BJC;4BS4;4BU3;4BU5;4BU6;4BU7;4BU8;4BU9;4BUA;4BUD;4BUE;4BUF;4BUI;4BUS;4BUT;4BUU;4BUV;4BUW;4BUX;4BUY;4HKI;4HKK;4HKN;4HL5;4HLF;4HLG;4HLH;4HLK;4HLM;4HMH;4HYF;4IUE;4J1Z;4J21;4J22;4J3L;4J3M;4KZL;4KZQ;4KZU;4L09;4L0B;4L0I;4L0S;4L0T;4L0V;4L10;4L2F;4L2G;4L2K;4L31;4L32;4L33;4L34;4M7B;4PML;4PNL;4PNM;4PNN;4PNQ;4PNR;4PNS;4PNT;4TJU;4TJW;4TJY;4TK0;4TK5;4TKF;4TKG;4TKI;4UFU;4UFY;4UHG;4UI3;4UI4;4UI5;4UI6;4UI7;4UI8;4UVL;4UVN;4UVO;4UVP;4UVS;4UVT;4UVU;4UVV;4UVW;4UVX;4UVY;4UVZ;4UX4;4W5I;4Z68;5ADQ;5ADR;5ADS;5ADT;5AEH;5AKU;5AKW;5AL1;5AL2;5AL3;5AL4;5AL5;5BXO;5BXU;5C5P;5C5Q;5C5R;5DCZ;5FPF;5FPG;5JRT;5NOB;5NSP;5NUT;5OWS;5OWT;

name:
Tankyrase-2 (TANK2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-like protein) (Tankyrase-related protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi membrane [GO:0000139]; nuclear chromosome, telomeric region [GO:0000784]; nuclear envelope [GO:0005635]; nucleus [GO:0005634]; pericentriolar material [GO:0000242]; perinuclear region of cytoplasm [GO:0048471]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; NAD+ ADP-ribosyltransferase activity [GO:0003950]; multicellular organism growth [GO:0035264]; negative regulation of telomere maintenance via telomere lengthening [GO:1904357]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of telomere capping [GO:1904355]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein ADP-ribosylation [GO:0006471]; protein auto-ADP-ribosylation [GO:0070213]; protein localization to chromosome, telomeric region [GO:0070198]; protein polyubiquitination [GO:0000209]; regulation of multicellular organism growth [GO:0040014]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.


uniprotID: Q6PEY1
geneSymbol: TMEM88
name: Transmembrane protein 88
length: 159
go: ENSG00000167874;
snps: rs2270518
sequence:
MADVPGAQRAVPGDGPEPRDPLDCWACAVLVTAQNLLVAAFNLLLLVLVLGTILLPAVTMLGFGFLCHSQFLRSQAPPCTAHLRDPGFTALLVTGFLLLVPLLVLALASYRRLCLRLRLADCLVPYSRALYRRRRAPQPRQIRASPGSQAVPTSGKVWV

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; PDZ domain binding [GO:0030165]; multicellular organism development [GO:0007275]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; protein localization to plasma membrane [GO:0072659]; protein stabilization [GO:0050821]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21044957}; Multi-pass membrane protein {ECO:0000269|PubMed:21044957}.


uniprotID: O75204
geneSymbol: TMEM127
name: Transmembrane protein 127
length: 238
go: ENSG00000135956;
snps: rs121908818 rs121908819 rs121908820 rs121908823 rs121908824 rs121908827 rs121908828
sequence:

opentargets:
cytoplasm [GO:0005737]; early endosome [GO:0005769]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; Rab GTPase binding [GO:0017137]; endosome organization [GO:0007032]; negative regulation of cell proliferation [GO:0008285]; negative regulation of TOR signaling [GO:0032007]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}; Multi-pass membrane protein {ECO:0000269|PubMed:20154675}. Cytoplasm {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000269|PubMed:20154675, ECO:0000269|PubMed:21156949}.


uniprotID: Q5VVB8
geneSymbol: TMEM244
name: Transmembrane protein 244
length: 128
go: ENSG00000203756;
opentargets: integral component of membrane [GO:0016021]
snps: rs7760577 rs4629709 rs9492393 rs7776426
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MALQVRVAPSKVVLQKFLLCVILFYTVYYVSLSMGCVMFEVHELNVLAPFDFKTNPSWLNINYKVLLVSTEVTYFVCGLFFVPVVEEWVWDYAISVTILHVAITSTVMLEFPLTSHWWAALGISKLLV


uniprotID: Q6ZT21
geneSymbol: TMPPE
name: Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-)
length: 453
go: ENSG00000188167;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZT21-1; Sequence=Displayed; Name=2; IsoId=Q6ZT21-2; Sequence=VSP_031858; Note=No experimental confirmation available.; 


uniprotID: O75663
geneSymbol: TIPRL
pdb: 5D9G;
name: TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)
length: 272
go: ENSG00000143155;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17944932}.
sequence:

opentargets:
cytosol [GO:0005829]; DNA damage checkpoint [GO:0000077]; negative regulation of phosphoprotein phosphatase activity [GO:0032515]; signal transduction [GO:0007165]; TOR signaling [GO:0031929]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75663-1; Sequence=Displayed; Name=2; Synonyms=TIP_i2; IsoId=O75663-2; Sequence=VSP_027883, VSP_027884; 


uniprotID: Q6UXY8
geneSymbol: TMC5
name: Transmembrane channel-like protein 5
length: 1006
go: ENSG00000103534;
snps: rs16972013 rs36019638
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; ion channel activity [GO:0005216]; mechanosensitive ion channel activity [GO:0008381]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6UXY8-1; Sequence=Displayed; Name=2; IsoId=Q6UXY8-2; Sequence=VSP_026046; Name=3; IsoId=Q6UXY8-3; Sequence=VSP_026044, VSP_026045; Name=4; IsoId=Q6UXY8-4; Sequence=VSP_026043; Note=No experimental confirmation available.; 


uniprotID: Q9BRR3
geneSymbol: TMEM246
name: Transmembrane protein 246
length: 403
go: ENSG00000165152;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q6YI46
geneSymbol: TMEM64
name: Transmembrane protein 64
length: 380
go: ENSG00000180694;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of bone resorption [GO:0045780]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of osteoclast differentiation [GO:0045672]; regulation of ATPase activity [GO:0043462]; regulation of cytosolic calcium ion concentration [GO:0051480]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6YI46-1; Sequence=Displayed; Name=2; IsoId=Q6YI46-2; Sequence=VSP_025441, VSP_025442; Name=3; IsoId=Q6YI46-3; Sequence=VSP_044998, VSP_044999; Note=No experimental confirmation available.; Name=4; IsoId=Q6YI46-4; Sequence=VSP_044999; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q3U145}.


uniprotID: Q6ZVM7
geneSymbol: TOM1L2
name: TOM1-like protein 2 (Target of Myb-like protein 2)
length: 507
go: ENSG00000175662;
sequence:

opentargets:
extracellular exosome [GO:0070062]; intracellular [GO:0005622]; clathrin binding [GO:0030276]; protein kinase binding [GO:0019901]; intracellular protein transport [GO:0006886]; negative regulation of mitotic nuclear division [GO:0045839]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q6ZVM7-1; Sequence=Displayed; Name=2; IsoId=Q6ZVM7-2; Sequence=VSP_023391; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZVM7-3; Sequence=VSP_023392; Name=4; IsoId=Q6ZVM7-4; Sequence=VSP_023390; Note=No experimental confirmation available.; Name=5; IsoId=Q6ZVM7-5; Sequence=VSP_057214, VSP_057215; Note=No experimental confirmation available.; 


uniprotID: Q9BXR5
geneSymbol: TLR10
reactome: R-HSA-168142;R-HSA-5603037;R-HSA-975871;
pdb: 2J67;
name: Toll-like receptor 10 (CD antigen CD290)
length: 811
go: ENSG00000174123;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; transmembrane signaling receptor activity [GO:0004888]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; positive regulation of inflammatory response [GO:0050729]; regulation of cytokine secretion [GO:0050707]; toll-like receptor 10 signaling pathway [GO:0034166]; toll-like receptor signaling pathway [GO:0002224]

snps:
rs11466649 rs11466650 rs11096957 rs11466651 rs11466653 rs11096955 rs11466655 rs11466656 rs11466657 rs11466658 rs11466660 rs4129009 rs4129009 rs4129009 rs4129008 rs4129008 rs4129008 


uniprotID: Q8IUR5
geneSymbol: TMTC1
name: Transmembrane and TPR repeat-containing protein 1
length: 882
go: ENSG00000133687;
opentargets: integral component of membrane [GO:0016021]; RNA processing [GO:0006396]
snps: rs17854190
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=5; IsoId=Q8IUR5-5; Sequence=Displayed; Name=1; IsoId=Q8IUR5-1; Sequence=VSP_041823; Name=2; IsoId=Q8IUR5-2; Sequence=VSP_023612, VSP_023613; Note=No experimental confirmation available.; Name=3; IsoId=Q8IUR5-3; Sequence=VSP_041823, VSP_023614, VSP_023615, VSP_023616; Note=No experimental confirmation available.; Name=4; IsoId=Q8IUR5-4; Sequence=VSP_023611, VSP_023617; Note=No experimental confirmation available.; 


uniprotID: Q9H808
geneSymbol: TLE6
name: Transducin-like enhancer protein 6
length: 572
go: ENSG00000104953;
snps: rs767222404
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; transcription factor complex [GO:0005667]; repressing transcription factor binding [GO:0070491]; transcription corepressor activity [GO:0003714]; embryonic process involved in female pregnancy [GO:0060136]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H808-1; Sequence=Displayed; Name=2; IsoId=Q9H808-2; Sequence=VSP_047216; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.


uniprotID: Q9HBJ8
geneSymbol: TMEM27
reactome: R-HSA-264876;
name: Collectrin (Transmembrane protein 27)
length: 222
go: ENSG00000147003;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; metallopeptidase activity [GO:0008237]; peptidyl-dipeptidase activity [GO:0008241]; protein homodimerization activity [GO:0042803]; positive regulation of calcium ion-dependent exocytosis [GO:0045956]; positive regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0035774]; positive regulation of SNARE complex assembly [GO:0035543]


uniprotID: Q5SWH9
geneSymbol: TMEM69
name: Transmembrane protein 69
length: 247
go: ENSG00000159596;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: A2RU14
geneSymbol: TMEM218
name: Transmembrane protein 218
length: 115
go: ENSG00000150433;
opentargets: cilium [GO:0005929]; integral component of membrane [GO:0016021]
sequence:
MAGTVLGVGAGVFILALLWVAVLLLCVLLSRASGAARFSVIFLFFGAVIITSVLLLFPRAGEFPAPEVEVKIVDDFFIGRYVLLAFLSAIFLGGLFLVLIHYVLEPIYAKPLHSY

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9CQ44}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250|UniProtKB:Q9CQ44}.


uniprotID: Q15025
geneSymbol: TNIP1
reactome: R-HSA-5689896;
length: 636
go: ENSG00000145901;
snps: rs2303018 rs2233289 rs2233290 rs2233292 rs2233295 rs117663772 rs185683917 rs748495842
name:
TNFAIP3-interacting protein 1 (A20-binding inhibitor of NF-kappa-B activation 1) (ABIN-1) (HIV-1 Nef-interacting protein) (Nef-associated factor 1) (Naf1) (Nip40-1) (Virion-associated nuclear shuttling protein) (VAN) (hVAN)

sequence:

opentargets:
cytosol [GO:0005829]; intracellular [GO:0005622]; nucleoplasm [GO:0005654]; identical protein binding [GO:0042802]; mitogen-activated protein kinase binding [GO:0051019]; defense response [GO:0006952]; glycoprotein biosynthetic process [GO:0009101]; inflammatory response [GO:0006954]; leukocyte cell-cell adhesion [GO:0007159]; modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade [GO:0085032]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of viral genome replication [GO:0045071]; positive regulation of inflammatory response [GO:0050729]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Alpha, FL; IsoId=Q15025-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q15025-2; Sequence=VSP_003913; Name=3; IsoId=Q15025-3; Sequence=VSP_045296; Name=4; Synonyms=Alpha2; IsoId=Q15025-4; Sequence=VSP_055208; Name=5; Synonyms=Alpha4; IsoId=Q15025-5; Sequence=VSP_055209, VSP_055214; Note=Less effective in the NF-kappa-B inhibitory effect.; Name=6; Synonyms=Beta2; IsoId=Q15025-6; Sequence=VSP_055208, VSP_003913; Name=7; Synonyms=Alpha3, Beta3; IsoId=Q15025-7; Sequence=VSP_055211, VSP_055212; Name=8; Synonyms=Beta4; IsoId=Q15025-8; Sequence=VSP_055210, VSP_055213; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.


uniprotID: Q8NFZ5
geneSymbol: TNIP2
reactome: R-HSA-5684264;R-HSA-5689896;
pdb: 5H07;
length: 429
go: ENSG00000168884;
snps: rs116129895 rs116412781 rs2269495
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12595760}. Nucleus {ECO:0000305}.
name:
TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; polyubiquitin modification-dependent protein binding [GO:0031593]; protein kinase binding [GO:0019901]; apoptotic process [GO:0006915]; CD40 signaling pathway [GO:0023035]; cellular response to lipopolysaccharide [GO:0071222]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; interleukin-1-mediated signaling pathway [GO:0070498]; negative regulation of endothelial cell apoptotic process [GO:2000352]; positive regulation of B cell activation [GO:0050871]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of macrophage activation [GO:0043032]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; stress-activated MAPK cascade [GO:0051403]; toll-like receptor 2 signaling pathway [GO:0034134]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 9 signaling pathway [GO:0034162]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:11390377, ECO:0000269|PubMed:12595760, ECO:0000269|PubMed:15489334}; IsoId=Q8NFZ5-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:14702039}; IsoId=Q8NFZ5-2; Sequence=VSP_052701; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: P01374
geneSymbol: LTA
reactome: R-HSA-5668541;R-HSA-5669034;R-HSA-5676594;
pdb: 1TNR;4MXV;4MXW;
name: Lymphotoxin-alpha (LT-alpha) (TNF-beta) (Tumor necrosis factor ligand superfamily member 1)
length: 205
go: ENSG00000226979;
drug: DB00005;
snps: rs2229094 rs2229092 rs1041981
sequence:

opentargets:
extracellular space [GO:0005615]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; apoptotic process [GO:0006915]; cell-cell signaling [GO:0007267]; defense response to Gram-positive bacterium [GO:0050830]; humoral immune response [GO:0006959]; lymph node development [GO:0048535]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of growth of symbiont in host [GO:0044130]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chronic inflammatory response to antigenic stimulus [GO:0002876]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of humoral immune response mediated by circulating immunoglobulin [GO:0002925]; positive regulation of interferon-gamma production [GO:0032729]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; response to lipopolysaccharide [GO:0032496]; response to nutrient [GO:0007584]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

location:
SUBCELLULAR LOCATION: Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.


uniprotID: O95807
geneSymbol: TMEM50A
name: Transmembrane protein 50A (Small membrane protein 1)
length: 157
go: ENSG00000183726;
snps: rs3093647
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MSGFLEGLRCSECIDWGEKRNTIASIAAGVLFFTGWWIIIDAAVIYPTMKDFNHSYHACGVIATIAFLMINAVSNGQVRGDSYSEGCLGQTGARIWLFVGFMLAFGSLIASMWILFGGYVAKEKDIVYPGIAVFFQNAFIFFGGLVFKFGRTEDLWQ

opentargets:
endoplasmic reticulum [GO:0005783]; glial cell projection [GO:0097386]; integral component of membrane [GO:0016021]; neuronal cell body [GO:0043025]; late endosome to vacuole transport via multivesicular body sorting pathway [GO:0032511]


uniprotID: Q5SNT2
geneSymbol: TMEM201
name: Transmembrane protein 201 (Spindle-associated membrane protein 1)
length: 666
go: ENSG00000188807;
sequence:

opentargets:
cytoplasm [GO:0005737]; integral component of nuclear inner membrane [GO:0005639]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; spindle pole [GO:0000922]; actin filament binding [GO:0051015]; lamin binding [GO:0005521]; centrosome localization [GO:0051642]; fibroblast migration [GO:0010761]; nuclear envelope organization [GO:0006998]; nuclear migration along microtubule [GO:0030473]; protein localization to nuclear envelope [GO:0090435]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5SNT2-1; Sequence=Displayed; Name=2; Synonyms=SAMP1; IsoId=Q5SNT2-2; Sequence=VSP_030915, VSP_030916; 

location:
SUBCELLULAR LOCATION: Isoform 2: Nucleus inner membrane {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}; Multi-pass membrane protein {ECO:0000269|PubMed:19494128}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19494128}. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane in distinct micro-domains and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle. {ECO:0000269|PubMed:19494128, ECO:0000269|PubMed:21610090}.


uniprotID: Q9UNS1
geneSymbol: TIMELESS
reactome: R-HSA-5693607;
pdb: 4XHT;4XHU;4XHW;5MQI;
name: Protein timeless homolog (hTIM)
length: 1208
go: ENSG00000111602;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17141802}.
sequence:

opentargets:
nuclear chromatin [GO:0000790]; nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork protection complex [GO:0031298]; DNA binding [GO:0003677]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; branching morphogenesis of an epithelial tube [GO:0048754]; cell cycle phase transition [GO:0044770]; cell division [GO:0051301]; cellular response to bleomycin [GO:1904976]; cellular response to cisplatin [GO:0072719]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to hydroxyurea [GO:0072711]; circadian rhythm [GO:0007623]; detection of abiotic stimulus [GO:0009582]; DNA repair [GO:0006281]; DNA replication checkpoint [GO:0000076]; lung development [GO:0030324]; morphogenesis of an epithelium [GO:0002009]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of double-strand break repair [GO:2000781]; regulation of circadian rhythm [GO:0042752]; replication fork arrest [GO:0043111]; replication fork protection [GO:0048478]

snps:
rs72478986 rs774027 rs72478993 rs774047 rs61733875 rs72478999 rs72479000 rs151188513 rs61376834 rs2291739 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:9856465, ECO:0000269|PubMed:9891984}; IsoId=Q9UNS1-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:9856465}; IsoId=Q9UNS1-2; Sequence=VSP_051693; 


uniprotID: O96008
geneSymbol: TOMM40
reactome: R-HSA-1268020;R-HSA-5205685;
length: 361
go: ENSG00000130204;
name:
Mitochondrial import receptor subunit TOM40 homolog (Protein Haymaker) (Translocase of outer membrane 40 kDa subunit homolog) (p38.5)

sequence:

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of mitochondrial outer membrane [GO:0031307]; mitochondrial inner membrane [GO:0005743]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; pore complex [GO:0046930]; porin activity [GO:0015288]; protein transmembrane transporter activity [GO:0008320]; ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]; protein targeting to mitochondrion [GO:0006626]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O96008-1; Sequence=Displayed; Name=2; IsoId=O96008-2; Sequence=VSP_008589, VSP_008590; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15644312}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q5HYL7
geneSymbol: TMEM196
name: Transmembrane protein 196
length: 178
go: ENSG00000173452;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHKPQLGDSSPVWSGVCFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEITDNMSNGGPQLIFNGRV

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5HYL7-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q5HYL7-2; Sequence=VSP_030928; Note=No experimental confirmation available.; Name=3; IsoId=Q5HYL7-3; Sequence=VSP_030928, VSP_030929; Note=No experimental confirmation available.; Name=4; IsoId=Q5HYL7-4; Sequence=VSP_039208; 


uniprotID: Q0P6H9
geneSymbol: TMEM62
name: Transmembrane protein 62
length: 643
go: ENSG00000137842;
opentargets: integral component of membrane [GO:0016021]; hydrolase activity [GO:0016787]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q93038
geneSymbol: TNFRSF25
reactome: R-HSA-5669034;
length: 417
go: ENSG00000215788;
snps: rs35771371 rs11800462 rs34529016 rs1064590 rs1059333
name:
Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; tumor necrosis factor-activated receptor activity [GO:0005031]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell surface receptor signaling pathway [GO:0007166]; regulation of apoptotic process [GO:0042981]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=12;  Name=1; Synonyms=WSL-1, LARD-1A; IsoId=Q93038-1; Sequence=Displayed; Name=2; Synonyms=LARD-1B; IsoId=Q93038-2; Sequence=VSP_006504; Name=3; Synonyms=WSL-S1, LARD-3; IsoId=Q93038-3; Sequence=VSP_006497, VSP_006498; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=WSL-S2, LARD-2; IsoId=Q93038-4; Sequence=VSP_006501, VSP_006502; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=LARD-4, LARD-11; IsoId=Q93038-5; Sequence=VSP_006495; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; Synonyms=LARD-5; IsoId=Q93038-6; Sequence=VSP_006491, VSP_006495; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=7; Synonyms=LARD-6; IsoId=Q93038-7; Sequence=VSP_006491, VSP_006493, VSP_006494; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=8; Synonyms=LARD-7; IsoId=Q93038-8; Sequence=VSP_006492; Name=9; Synonyms=LARD-8; IsoId=Q93038-9; Sequence=VSP_006491; Name=10; Synonyms=LARD-9; IsoId=Q93038-10; Sequence=VSP_006503; Name=11; Synonyms=Beta; IsoId=Q93038-11; Sequence=VSP_006496; Name=12; Synonyms=Beta soluble; IsoId=Q93038-12; Sequence=VSP_006499, VSP_006500; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 9: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 11: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Secreted.; SUBCELLULAR LOCATION: Isoform 4: Secreted.; SUBCELLULAR LOCATION: Isoform 5: Secreted.; SUBCELLULAR LOCATION: Isoform 6: Secreted.; SUBCELLULAR LOCATION: Isoform 7: Secreted.; SUBCELLULAR LOCATION: Isoform 8: Secreted.; SUBCELLULAR LOCATION: Isoform 10: Secreted.; SUBCELLULAR LOCATION: Isoform 12: Secreted.


uniprotID: Q14106
geneSymbol: TOB2
name: Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2)
length: 344
go: ENSG00000183864;
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; transcription corepressor activity [GO:0003714]; vitamin D receptor binding [GO:0042809]; female gamete generation [GO:0007292]; negative regulation of cell proliferation [GO:0008285]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of ossification [GO:0045778]; regulation of gene expression [GO:0010468]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q14106-1; Sequence=Displayed; Name=2; IsoId=Q14106-2; Sequence=VSP_055557; Note=No experimental confirmation available.; 


uniprotID: O95411
geneSymbol: TIAF1
name: TGFB1-induced anti-apoptotic factor 1 (12 kDa TGF-beta-1-induced antiapoptotic factor)
length: 115
go: ENSG00000221995;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9918798}.
sequence:
MSSPSSPFREQSFLCAAGDAGEESRVQVLKNEVRRGSPVLLGWVEQAYADKCVCGPSAPPAPTPPSLSQRVMCNDLFKVNPFQLQQFRADPSTASLLLCPGGLDHKLNLRGKAWG

opentargets:
nucleus [GO:0005634]; apoptotic process [GO:0006915]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; negative regulation of apoptotic process [GO:0043066]


uniprotID: Q9BZD6
geneSymbol: PRRG4
length: 226
go: ENSG00000135378;
snps: rs33962176 rs34736080 rs34139105
name:
Transmembrane gamma-carboxyglutamic acid protein 4 (Proline-rich gamma-carboxyglutamic acid protein 4) (Proline-rich Gla protein 4)

sequence:

opentargets:
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; calcium ion binding [GO:0005509]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:28859078}; Single-pass membrane protein {ECO:0000305|PubMed:28859078}.


uniprotID: Q04726
geneSymbol: TLE3
reactome: R-HSA-201722;R-HSA-2122947;R-HSA-3769402;R-HSA-4641265;R-HSA-9018519;
name: Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
length: 772
go: ENSG00000140332;
snps: rs1057864
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; repressing transcription factor binding [GO:0070491]; transcription corepressor activity [GO:0003714]; animal organ morphogenesis [GO:0009887]; beta-catenin-TCF complex assembly [GO:1904837]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cold-induced thermogenesis [GO:0120163]; regulation of transcription, DNA-templated [GO:0006355]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q04726-1; Sequence=Displayed; Name=2; IsoId=Q04726-2; Sequence=VSP_006788; Name=3; IsoId=Q04726-3; Sequence=VSP_006789, VSP_006790; Name=4; IsoId=Q04726-4; Sequence=VSP_007023, VSP_007024, VSP_006790; Name=5; IsoId=Q04726-5; Sequence=VSP_006789; Note=No experimental confirmation available. {ECO:0000244|PubMed:19608861}; Name=6; IsoId=Q04726-6; Sequence=VSP_054598; Note=No experimental confirmation available.; Name=7; IsoId=Q04726-7; Sequence=VSP_055168, VSP_006789; 


uniprotID: P45379
geneSymbol: TNNT2
reactome: R-HSA-390522;
pdb: 1J1D;1J1E;4Y99;
name: Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
length: 298
go: ENSG00000118194;
sequence:

opentargets:
cardiac myofibril [GO:0097512]; cardiac Troponin complex [GO:1990584]; cytosol [GO:0005829]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; troponin complex [GO:0005861]; actin binding [GO:0003779]; calcium ion binding [GO:0005509]; protein binding, bridging [GO:0030674]; tropomyosin binding [GO:0005523]; troponin C binding [GO:0030172]; troponin I binding [GO:0031013]; actin crosslink formation [GO:0051764]; cardiac muscle contraction [GO:0060048]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; negative regulation of ATPase activity [GO:0032780]; positive regulation of ATPase activity [GO:0032781]; protein heterooligomerization [GO:0051291]; regulation of heart contraction [GO:0008016]; regulation of muscle filament sliding speed [GO:0032972]; response to calcium ion [GO:0051592]; sarcomere organization [GO:0045214]; skeletal muscle contraction [GO:0003009]; ventricular cardiac muscle tissue morphogenesis [GO:0055010]

snps:
rs200754249 rs886039053 rs121964855 rs121964856 rs121964856 rs397516456 rs397516457 rs727504245 rs121964858 rs121964858 rs2996496 rs397516463 rs2996496 rs74315380 rs74315379 rs727504246 rs121964860 rs45520032 rs45520032 rs2996495 rs45466197 rs3730238 rs4523540 rs863225119 rs121964857 rs397516484 rs367785431 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=12;  Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=TNT1; IsoId=P45379-1; Sequence=Displayed; Name=2; IsoId=P45379-2; Sequence=VSP_006644; Name=3; IsoId=P45379-3; Sequence=VSP_006645; Name=4; IsoId=P45379-4; Sequence=VSP_006644, VSP_006645; Name=5; IsoId=P45379-5; Sequence=VSP_006647; Name=6; Synonyms=TNT3; IsoId=P45379-6; Sequence=VSP_006643; Name=7; Synonyms=TNT4; IsoId=P45379-7; Sequence=VSP_006642; Name=8; Synonyms=TNT2; IsoId=P45379-8; Sequence=VSP_006641; Name=9; IsoId=P45379-9; Sequence=VSP_006646; Name=10; IsoId=P45379-10; Sequence=VSP_006648; Name=11; IsoId=P45379-11; Sequence=VSP_006643, VSP_006648; Note=No experimental confirmation available.; Name=12; IsoId=P45379-12; Sequence=VSP_006645, VSP_006646, VSP_006648; 


uniprotID: O15455
geneSymbol: TLR3
pdb: 1ZIW;2A0Z;2MK9;2MKA;3ULU;3ULV;5GS0;
name: Toll-like receptor 3 (CD antigen CD283)
length: 904
go: ENSG00000164342;
snps: rs5743316 rs5743317 rs3775291 rs121434431 rs5743318
reactome:
R-HSA-1679131;R-HSA-168164;R-HSA-168927;R-HSA-1810476;R-HSA-5602410;R-HSA-5602415;R-HSA-5602566;R-HSA-5602571;R-HSA-9013957;R-HSA-9013973;R-HSA-9014325;R-HSA-937072;R-HSA-975163;

sequence:

opentargets:
cytoplasm [GO:0005737]; early endosome [GO:0005769]; endolysosome membrane [GO:0036020]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; apoptotic signaling pathway [GO:0097190]; cellular response to drug [GO:0035690]; cellular response to exogenous dsRNA [GO:0071360]; cellular response to interferon-beta [GO:0035458]; cellular response to interferon-gamma [GO:0071346]; cellular response to mechanical stimulus [GO:0071260]; defense response to bacterium [GO:0042742]; defense response to virus [GO:0051607]; detection of virus [GO:0009597]; extrinsic apoptotic signaling pathway [GO:0097191]; hyperosmotic response [GO:0006972]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; I-kappaB phosphorylation [GO:0007252]; innate immune response [GO:0045087]; male gonad development [GO:0008584]; microglial cell activation [GO:0001774]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; negative regulation of osteoclast differentiation [GO:0045671]; positive regulation of angiogenesis [GO:0045766]; positive regulation of apoptotic process [GO:0043065]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of chemokine production [GO:0032722]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha biosynthetic process [GO:0045356]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interferon-gamma biosynthetic process [GO:0045078]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of toll-like receptor signaling pathway [GO:0034123]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor production [GO:0032760]; positive regulation of type III interferon production [GO:0034346]; regulation of dendritic cell cytokine production [GO:0002730]; response to exogenous dsRNA [GO:0043330]; signal transduction [GO:0007165]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15455-1; Sequence=Displayed; Name=2; IsoId=O15455-2; Sequence=VSP_054188; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome {ECO:0000269|PubMed:25736436}.


uniprotID: P48023
geneSymbol: FASLG
pdb: 1BZI;4MSV;5L19;5L36;
length: 281
go: ENSG00000117560;
snps: rs12079514
reactome:
R-HSA-140534;R-HSA-3371378;R-HSA-5213460;R-HSA-5218900;R-HSA-6785807;R-HSA-69416;R-HSA-75157;R-HSA-8862803;

name:
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]

sequence:

opentargets:
caveola [GO:0005901]; cytoplasmic vesicle lumen [GO:0060205]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; lysosomal lumen [GO:0043202]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; death receptor binding [GO:0005123]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cell-cell signaling [GO:0007267]; cellular chloride ion homeostasis [GO:0030644]; cytokine-mediated signaling pathway [GO:0019221]; endosomal lumen acidification [GO:0048388]; extrinsic apoptotic signaling pathway [GO:0097191]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; immune response [GO:0006955]; inflammatory cell apoptotic process [GO:0006925]; necroptotic process [GO:0070266]; necroptotic signaling pathway [GO:0097527]; negative regulation of angiogenesis [GO:0016525]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell apoptotic process [GO:2000353]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of neuron apoptotic process [GO:0043525]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; release of sequestered calcium ion into cytosol by endoplasmic reticulum [GO:1903514]; response to growth factor [GO:0070848]; response to lipopolysaccharide [GO:0032496]; retinal cell programmed cell death [GO:0046666]; signal transduction [GO:0007165]; T cell apoptotic process [GO:0070231]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48023-1; Sequence=Displayed; Name=2; IsoId=P48023-2; Sequence=VSP_006443, VSP_006444; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:9427603}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:17164290}. Lysosome lumen {ECO:0000269|PubMed:17164290}. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination (PubMed:17164290). Colocalizes with the SPPL2A protease at the cell membrane (PubMed:17557115). {ECO:0000269|PubMed:17164290, ECO:0000269|PubMed:17557115}.; SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted {ECO:0000269|PubMed:9427603}. Note=May be released into the extracellular fluid by cleavage from the cell surface. {ECO:0000269|PubMed:9427603}.; SUBCELLULAR LOCATION: FasL intracellular domain: Nucleus {ECO:0000269|PubMed:17557115}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000269|PubMed:17557115}.


uniprotID: Q4KMQ1
geneSymbol: TPRN
name: Taperin
length: 711
go: ENSG00000176058;
sequence:

opentargets:
stereocilium [GO:0032420]; phosphatase binding [GO:0019902]; sensory perception of sound [GO:0007605]; stereocilium maintenance [GO:0120045]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q4KMQ1-1; Sequence=Displayed; Name=2; IsoId=Q4KMQ1-2; Sequence=VSP_033027; Name=3; IsoId=Q4KMQ1-3; Sequence=VSP_033027, VSP_033028; Name=4; IsoId=Q4KMQ1-4; Sequence=VSP_039038, VSP_039039; 

location:
SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}. Note=Localized prominently at the taper regions of hair cell stereocilia. {ECO:0000250}.


uniprotID: Q9C0B7
geneSymbol: TANGO6
length: 1094
go: ENSG00000103047;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
name:
Transport and Golgi organization protein 6 homolog (Transmembrane and coiled-coil domain-containing protein 7)

sequence:


uniprotID: P28908
geneSymbol: TNFRSF8
reactome: R-HSA-5669034;
pdb: 1D01;
length: 595
go: ENSG00000120949;
drug: DB08870;
snps: rs2230624 rs2230624 rs1763642 rs2275170 rs2230625 rs35511003
name:
Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; transmembrane signaling receptor activity [GO:0004888]; cellular response to mechanical stimulus [GO:0071260]; negative regulation of cell proliferation [GO:0008285]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of TRAIL biosynthetic process [GO:0045556]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=3;  Name=1; Synonyms=Long; IsoId=P28908-1; Sequence=Displayed; Name=2; Synonyms=Cytoplasmic, Short, C30V; IsoId=P28908-2; Sequence=VSP_018900; Name=3; IsoId=P28908-3; Sequence=VSP_055032, VSP_055033; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.


uniprotID: P0DKB5
geneSymbol: TPBGL
name: Trophoblast glycoprotein-like
length: 382
go: ENSG00000261594;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:


uniprotID: Q12933
geneSymbol: TRAF2
pdb: 1CA4;1CA9;1CZY;1CZZ;1D00;1D01;1D0A;1D0J;1F3V;1QSC;3KNV;3M06;3M0A;3M0D;
length: 501
go: ENSG00000127191;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:19150425}.
reactome:
R-HSA-140534;R-HSA-3371378;R-HSA-5213460;R-HSA-5218900;R-HSA-5357786;R-HSA-5357905;R-HSA-5357956;R-HSA-5668541;R-HSA-5675482;R-HSA-5676594;R-HSA-5689880;R-HSA-69416;R-HSA-75893;R-HSA-933541;R-HSA-933542;

name:
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)

sequence:

opentargets:
AIP1-IRE1 complex [GO:1990597]; CD40 receptor complex [GO:0035631]; cell cortex [GO:0005938]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; IRE1-TRAF2-ASK1 complex [GO:1990604]; membrane raft [GO:0045121]; nucleoplasm [GO:0005654]; TRAF2-GSTP1 complex [GO:0097057]; ubiquitin ligase complex [GO:0000151]; vesicle membrane [GO:0012506]; CD40 receptor binding [GO:0005174]; enzyme binding [GO:0019899]; identical protein binding [GO:0042802]; mitogen-activated protein kinase kinase kinase binding [GO:0031435]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; protein-containing complex binding [GO:0044877]; sphingolipid binding [GO:0046625]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; activation of NF-kappaB-inducing kinase activity [GO:0007250]; cellular protein-containing complex assembly [GO:0034622]; cellular response to nitric oxide [GO:0071732]; death-inducing signaling complex assembly [GO:0071550]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; negative regulation of glial cell apoptotic process [GO:0034351]; negative regulation of neuron death [GO:1901215]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of interleukin-2 production [GO:0032743]; positive regulation of JUN kinase activity [GO:0043507]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of T cell cytokine production [GO:0002726]; positive regulation of tumor necrosis factor-mediated signaling pathway [GO:1903265]; programmed necrotic cell death [GO:0097300]; protein autoubiquitination [GO:0051865]; protein catabolic process [GO:0030163]; protein deubiquitination [GO:0016579]; protein heterooligomerization [GO:0051291]; protein homotrimerization [GO:0070207]; protein K63-linked ubiquitination [GO:0070534]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of immunoglobulin secretion [GO:0051023]; regulation of tumor necrosis factor-mediated signaling pathway [GO:0010803]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q12933-1; Sequence=Displayed; Name=2; IsoId=Q12933-2; Sequence=VSP_007401; Note=No experimental confirmation available.; Name=3; IsoId=Q12933-3; Sequence=VSP_039687; Note=No experimental confirmation available.; Name=4; IsoId=Q12933-4; Sequence=VSP_039688; Note=No experimental confirmation available.; 


uniprotID: Q6PJ69
geneSymbol: TRIM65
name: Tripartite motif-containing protein 65
length: 517
go: ENSG00000141569;
snps: rs7222757 rs34593741 rs9892938 rs3760128
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; positive regulation of autophagy [GO:0010508]


uniprotID: Q96DX7
geneSymbol: TRIM44
name: Tripartite motif-containing protein 44 (Protein DIPB)
length: 344
go: ENSG00000166326;
snps: rs377117775 rs886039241
sequence:

opentargets:
intracellular [GO:0005622]; zinc ion binding [GO:0008270]; negative regulation of protein K48-linked ubiquitination [GO:0061944]; positive regulation of cytokine-mediated signaling pathway [GO:0001961]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of transcription, DNA-templated [GO:0045893]; protein stabilization [GO:0050821]; regulation of gene expression [GO:0010468]


uniprotID: P36406
geneSymbol: TRIM23
pdb: 5VZV;5VZW;
length: 574
go: ENSG00000113595;
snps: rs34046496
name:
E3 ubiquitin-protein ligase TRIM23 (EC 2.3.2.27) (ADP-ribosylation factor domain-containing protein 1) (GTP-binding protein ARD-1) (RING finger protein 46) (RING-type E3 ubiquitin transferase TRIM23) (Tripartite motif-containing protein 23)

sequence:

opentargets:
cytoplasm [GO:0005737]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; lysosomal membrane [GO:0005765]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; enzyme activator activity [GO:0008047]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; identical protein binding [GO:0042802]; nucleic acid binding [GO:0003676]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; Golgi to plasma membrane transport [GO:0006893]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; protein ubiquitination [GO:0016567]; vesicle-mediated transport [GO:0016192]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Alpha; IsoId=P36406-1; Sequence=Displayed; Name=Beta; IsoId=P36406-2; Sequence=VSP_000296; Name=Gamma; IsoId=P36406-3; Sequence=VSP_000297; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28871090}. Endomembrane system {ECO:0000269|PubMed:9671726}. Golgi apparatus membrane {ECO:0000269|PubMed:9671726}. Lysosome membrane {ECO:0000269|PubMed:9671726}. Note=Membrane-associated with the Golgi complex and lysosomal structures.


uniprotID: Q9BYV2
geneSymbol: TRIM54
pdb: 3Q1D;
length: 358
go: ENSG00000138100;
name:
Tripartite motif-containing protein 54 (Muscle-specific RING finger protein) (MuRF) (Muscle-specific RING finger protein 3) (MuRF-3) (MuRF3) (RING finger protein 30)

sequence:

opentargets:
microtubule [GO:0005874]; microtubule associated complex [GO:0005875]; Z disc [GO:0030018]; microtubule binding [GO:0008017]; zinc ion binding [GO:0008270]; microtubule-based process [GO:0007017]; multicellular organism development [GO:0007275]; muscle cell development [GO:0055001]; negative regulation of microtubule depolymerization [GO:0007026]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BYV2-1; Sequence=Displayed; Name=2; IsoId=Q9BYV2-2; Sequence=VSP_016061; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). {ECO:0000250}.


uniprotID: O43715
geneSymbol: TRIAP1
reactome: R-HSA-6803204;
pdb: 4XZS;4XZV;
sequence: MNSVGEACTDMKREYDQCFNRWFAEKFLKGDSSGDPCTDLFKRYQQCVQKAIKEKEIPIEGLEFMGHGKEKPENSS
length: 76
go: ENSG00000170855;
name:
TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV)

opentargets:
mitochondrial intermembrane space [GO:0005758]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; protein-containing complex [GO:0032991]; p53 binding [GO:0002039]; apoptotic process [GO:0006915]; cellular response to UV [GO:0034644]; DNA damage response, signal transduction by p53 class mediator [GO:0030330]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of release of cytochrome c from mitochondria [GO:0090201]; phospholipid transport [GO:0015914]; positive regulation of phospholipid transport [GO:2001140]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of membrane lipid distribution [GO:0097035]

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:15735003}. Mitochondrion {ECO:0000269|PubMed:15735003, ECO:0000269|PubMed:23931759}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23931759}.


uniprotID: Q9UPQ4
geneSymbol: TRIM35
reactome: R-HSA-877300;
name: Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5)
length: 493
go: ENSG00000104228;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of mitotic cell cycle [GO:0045930]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of apoptotic process [GO:0043065]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UPQ4-1; Sequence=Displayed; Name=2; IsoId=Q9UPQ4-2; Sequence=VSP_012061; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25263439}. Nucleus {ECO:0000250}. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies (By similarity). {ECO:0000250}.


uniprotID: Q8N6I4
geneSymbol: TMEM251
name: Transmembrane protein 251
length: 163
go: ENSG00000153485;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MPKPPDYSELSDSLTLAVGTGRFSGPLHRAWRMMNFRQRMGWIGVGLYLLASAAAFYYVFEISETYNRLALEHIQQHPEEPLEGTTWTHSLKAQLLSLPFWVWTVIFLVPYLQMFLFLYSCTRADPKTVGYCIIPICLAVICNRHQAFVKASNQISRLQLIDT

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N6I4-1; Sequence=Displayed; Name=2; IsoId=Q8N6I4-2; Sequence=VSP_036175; Name=3; IsoId=Q8N6I4-3; Sequence=VSP_045689; Note=No experimental confirmation available.; 


uniprotID: Q8N9V7
geneSymbol: TOPAZ1
name: Protein TOPAZ1 (Testis- and ovary-specific PAZ domain-containing protein 1)
length: 1692
go: ENSG00000173769;
snps: rs9833423 rs7645375 rs9284879 rs17076541 rs17646517 rs17076545 rs11921568
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:E5FYH1}.
sequence:

opentargets:
cytosol [GO:0005829]; apoptotic process [GO:0006915]; ncRNA transcription [GO:0098781]; positive regulation of meiotic cell cycle phase transition [GO:1901995]; spermatid development [GO:0007286]; spermatocyte division [GO:0048137]


uniprotID: O95985
geneSymbol: TOP3B
pdb: 5GVC;5GVE;
name: DNA topoisomerase 3-beta-1 (EC 5.99.1.2) (DNA topoisomerase III beta-1)
length: 862
go: ENSG00000100038;
snps: rs9610728
sequence:

opentargets:
condensed chromosome [GO:0000793]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I activity [GO:0003917]; RNA binding [GO:0003723]; chromosome segregation [GO:0007059]; DNA topological change [GO:0006265]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O95985-1; Sequence=Displayed; Name=2; IsoId=O95985-2; Sequence=VSP_006525, VSP_006526; Name=3; IsoId=O95985-3; Sequence=VSP_006527, VSP_006528; 


uniprotID: Q9H0E2
geneSymbol: TOLLIP
reactome: R-HSA-6798695;R-HSA-9020702;
pdb: 1WGL;2N31;
name: Toll-interacting protein
length: 274
go: ENSG00000078902;
snps: rs1037270334 rs5744015
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
azurophil granule lumen [GO:0035578]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; interleukin-1 receptor complex [GO:0045323]; interleukin-18 receptor complex [GO:0045092]; nuclear body [GO:0016604]; perinuclear region of cytoplasm [GO:0048471]; specific granule lumen [GO:0035580]; interleukin-1, type I receptor binding [GO:0005150]; kinase binding [GO:0019900]; SUMO binding [GO:0032183]; Toll-like receptor binding [GO:0035325]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase binding [GO:0031625]; autophagy [GO:0006914]; cell-cell signaling [GO:0007267]; epithelial cell differentiation [GO:0030855]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interleukin-1-mediated signaling pathway [GO:0070498]; intracellular signal transduction [GO:0035556]; leukocyte activation [GO:0045321]; neutrophil degranulation [GO:0043312]; phosphorylation [GO:0016310]; positive regulation of protein sumoylation [GO:0033235]; protein localization to endosome [GO:0036010]; signal transduction [GO:0007165]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H0E2-1; Sequence=Displayed; Name=2; IsoId=Q9H0E2-2; Sequence=VSP_056301; Note=No experimental confirmation available.; 


uniprotID: Q8IWU9
geneSymbol: TPH2
reactome: R-HSA-209931;
pdb: 4V06;
length: 490
go: ENSG00000139287;
drug: DB00150;DB12095;
name:
Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2)

sequence:

opentargets:
cytosol [GO:0005829]; neuron projection [GO:0043005]; iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]; aromatic amino acid family metabolic process [GO:0009072]; cellular response to lithium ion [GO:0071285]; circadian rhythm [GO:0007623]; response to activity [GO:0014823]; response to calcium ion [GO:0051592]; response to estrogen [GO:0043627]; response to glucocorticoid [GO:0051384]; response to nutrient levels [GO:0031667]; serotonin biosynthetic process [GO:0042427]

snps:
rs199775778 rs34115267 rs78162420 rs75558144 rs17110563 rs120074176 rs2887147 rs120074175 rs7488262 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=a; IsoId=Q8IWU9-1; Sequence=Displayed; Name=b; IsoId=Q8IWU9-2; Sequence=VSP_040971; 


uniprotID: Q9NS69
geneSymbol: TOMM22
reactome: R-HSA-1268020;R-HSA-5205685;
length: 142
go: ENSG00000100216;
name:
Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog)

sequence:
MAAAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPSLPGKI

opentargets:
integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; mitochondrial outer membrane translocase complex [GO:0005742]; mitochondrion [GO:0005739]; protein transmembrane transporter activity [GO:0008320]; positive regulation of apoptotic process [GO:0043065]; protein import into mitochondrial outer membrane [GO:0045040]; protein insertion into mitochondrial membrane [GO:0051204]; protein targeting to mitochondrion [GO:0006626]

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:10982837}; Single-pass membrane protein {ECO:0000269|PubMed:10982837}.


uniprotID: Q309B1
geneSymbol: TRIM16L
name: Tripartite motif-containing protein 16-like protein (Tripartite motif-containing protein 70)
length: 348
go: ENSG00000108448;
opentargets: cytosol [GO:0005829]; plasma membrane [GO:0005886]
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q309B1-1; Sequence=Displayed; Name=2; IsoId=Q309B1-2; Sequence=VSP_044369, VSP_044370; 


uniprotID: Q07283
geneSymbol: TCHH
reactome: R-HSA-6809371;
name: Trichohyalin
length: 1943
go: ENSG00000159450;
snps: rs2515663 rs3134814 rs6680692 rs11803731 rs2496253 rs1131471
sequence:

opentargets:
cornified envelope [GO:0001533]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; calcium ion binding [GO:0005509]; transition metal ion binding [GO:0046914]; cornification [GO:0070268]; intermediate filament organization [GO:0045109]


uniprotID: Q13114
geneSymbol: TRAF3
pdb: 1FLK;1FLL;1KZZ;1L0A;1RF3;1ZMS;2ECY;2GKW;
length: 568
go: ENSG00000131323;
snps: rs143813189 rs1131877
reactome:
R-HSA-5602571;R-HSA-5668541;R-HSA-5676594;R-HSA-5689896;R-HSA-9013973;R-HSA-918233;R-HSA-936440;R-HSA-936964;

name:
TNF receptor-associated factor 3 (EC 2.3.2.27) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)

sequence:

opentargets:
CD40 receptor complex [GO:0035631]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; endosome [GO:0005768]; mitochondrion [GO:0005739]; protein kinase binding [GO:0019901]; protein phosphatase binding [GO:0019903]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; innate immune response [GO:0045087]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; protein deubiquitination [GO:0016579]; regulation of apoptotic process [GO:0042981]; regulation of cytokine production [GO:0001817]; regulation of defense response to virus [GO:0050688]; regulation of interferon-beta production [GO:0032648]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]; Toll signaling pathway [GO:0008063]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13114-1; Sequence=Displayed; Name=2; IsoId=Q13114-2; Sequence=VSP_040040; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Endosome {ECO:0000250|UniProtKB:Q60803}. Mitochondrion. Note=Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus. {ECO:0000250|UniProtKB:Q60803}.


uniprotID: Q7L0X0
geneSymbol: TRIL
name: TLR4 interactor with leucine rich repeats (Leucine-rich repeat-containing protein KIAA0644)
length: 811
go: ENSG00000255690;
snps: rs740250 rs3735561 rs3735562
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; lipopolysaccharide receptor complex [GO:0046696]; lipopolysaccharide binding [GO:0001530]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; regulation of cytokine production involved in immune response [GO:0002718]; toll-like receptor 4 signaling pathway [GO:0034142]


uniprotID: Q9NUP7
geneSymbol: TRMT13
reactome: R-HSA-6782315;
length: 481
go: ENSG00000122435;
snps: rs687513
name:
tRNA:m(4)X modification enzyme TRM13 homolog (EC 2.1.1.225) (Coiled-coil domain-containing protein 76)

sequence:

opentargets:
metal ion binding [GO:0046872]; tRNA 2'-O-methyltransferase activity [GO:0106050]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NUP7-1; Sequence=Displayed; Name=2; IsoId=Q9NUP7-2; Sequence=VSP_018578, VSP_018579; 


uniprotID: Q6ZTA4
geneSymbol: TRIM67
name: Tripartite motif-containing protein 67 (TRIM9-like protein)
length: 783
go: ENSG00000119283;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; zinc ion binding [GO:0008270]; negative regulation of Ras protein signal transduction [GO:0046580]; positive regulation of neuron projection development [GO:0010976]; positive regulation of ubiquitin-dependent protein catabolic process [GO:2000060]; regulation of cellular protein localization [GO:1903827]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZTA4-3; Sequence=Displayed; Note=Gene prediction based on EST data.; Name=2; IsoId=Q6ZTA4-2; Sequence=VSP_021359, VSP_021360; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Microtubule-associated. {ECO:0000250}.


uniprotID: Q6AZZ1
geneSymbol: TRIM68
reactome: R-HSA-877300;
length: 485
go: ENSG00000167333;
snps: rs2231975 rs2231976 rs7109316
location: SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.
name:
E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; androgen receptor binding [GO:0050681]; histone acetyltransferase binding [GO:0035035]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; interferon-gamma-mediated signaling pathway [GO:0060333]; protein autoubiquitination [GO:0051865]; regulation of androgen receptor signaling pathway [GO:0060765]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6AZZ1-1; Sequence=Displayed; Name=2; IsoId=Q6AZZ1-2; Sequence=VSP_055444, VSP_055445; Note=No experimental confirmation available.; 


uniprotID: Q86WT6
geneSymbol: TRIM69
reactome: R-HSA-983168;
pdb: 4NQJ;
length: 500
go: ENSG00000185880;
snps: rs2444007 rs2470911 rs3759880 rs17588988 rs3100139 rs3759880
name:
E3 ubiquitin-protein ligase TRIM69 (EC 2.3.2.27) (RFP-like domain-containing protein trimless) (RING finger protein 36) (RING-type E3 ubiquitin transferase TRIM69) (Tripartite motif-containing protein 69)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86WT6-1; Sequence=Displayed; Name=2; IsoId=Q86WT6-2; Sequence=VSP_023201; Name=3; Synonyms=Trimless alpha; IsoId=Q86WT6-3; Sequence=VSP_023200; Name=4; Synonyms=Trimless beta; IsoId=Q86WT6-4; Sequence=VSP_023200, VSP_023202; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23131556}. Nucleus {ECO:0000269|PubMed:23131556}. Nucleus speckle {ECO:0000269|PubMed:23131556}.


uniprotID: Q15650
geneSymbol: TRIP4
pdb: 2E5O;
length: 581
go: ENSG00000103671;
name:
Activating signal cointegrator 1 (ASC-1) (Thyroid receptor-interacting protein 4) (TR-interacting protein 4) (TRIP-4)

sequence:

opentargets:
activating signal cointegrator 1 complex [GO:0099053]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; neuromuscular junction [GO:0031594]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; estrogen receptor binding [GO:0030331]; histone acetyltransferase binding [GO:0035035]; nuclear receptor binding [GO:0016922]; protease binding [GO:0002020]; protein kinase binding [GO:0019901]; transcription coactivator activity [GO:0003713]; ubiquitin-like protein ligase binding [GO:0044389]; zinc ion binding [GO:0008270]; intracellular estrogen receptor signaling pathway [GO:0030520]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of myoblast differentiation [GO:0045661]; regulation of transcription, DNA-templated [GO:0006355]; toxin transport [GO:1901998]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:26924529}. Cytoplasm, cytosol {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}.


uniprotID: Q96A61
geneSymbol: TRIM52
name: Tripartite motif-containing protein 52 (RING finger protein 102)
length: 297
go: ENSG00000183718;
sequence:

opentargets:
nuclear body [GO:0016604]; zinc ion binding [GO:0008270]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]


uniprotID: Q9BYV6
geneSymbol: TRIM55
length: 548
go: ENSG00000147573;
snps: rs769797275 rs61741078 rs770907206 rs7843605 rs200545859 rs755876598 rs770146015 rs781152511
name:
Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)

sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; zinc ion binding [GO:0008270]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=p60; IsoId=Q9BYV6-1; Sequence=Displayed; Name=2; Synonyms=p50; IsoId=Q9BYV6-2; Sequence=VSP_015997; Name=3; Synonyms=p60B; IsoId=Q9BYV6-3; Sequence=VSP_015998; Name=4; Synonyms=p27; IsoId=Q9BYV6-4; Sequence=VSP_015996; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). {ECO:0000250}.


uniprotID: Q9BU70
geneSymbol: TRMO
name: tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)
length: 441
go: ENSG00000136932;
opentargets: tRNA (adenine-N6-)-methyltransferase activity [GO:0016430]; tRNA methylation [GO:0030488]
snps: rs3183927 rs35606344 rs2282192
sequence:


uniprotID: Q5T2D2
geneSymbol: TREML2
reactome: R-HSA-198933;
length: 321
go: ENSG00000112195;
snps: rs4418164 rs35512890 rs3747742 rs35521209
name:
Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2)

sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; regulation of immune response [GO:0050776]; T cell activation [GO:0042110]


uniprotID: Q12815
geneSymbol: TROAP
name: Tastin (Trophinin-assisting protein) (Trophinin-associated protein)
length: 778
go: ENSG00000135451;
opentargets: cytoplasm [GO:0005737]; cell adhesion [GO:0007155]
location: SUBCELLULAR LOCATION: Cytoplasm.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q12815-1; Sequence=Displayed; Name=2; IsoId=Q12815-2; Sequence=VSP_042820, VSP_042821; Note=No experimental confirmation available.; Name=3; IsoId=Q12815-3; Sequence=VSP_055063; Note=No experimental confirmation available.; 


uniprotID: Q9NZ43
geneSymbol: USE1
reactome: R-HSA-6811434;
name: Vesicle transport protein USE1 (Putative MAPK-activating protein PM26) (USE1-like protein) (p31)
length: 259
go: ENSG00000053501;
snps: rs414528
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; lysosomal transport [GO:0007041]; protein catabolic process [GO:0030163]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; secretion by cell [GO:0032940]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NZ43-1; Sequence=Displayed; Name=2; IsoId=Q9NZ43-2; Sequence=VSP_012664, VSP_012665; Note=No experimental confirmation available.; Name=3; IsoId=Q9NZ43-3; Sequence=VSP_012662, VSP_012663; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15029241}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15029241}.


uniprotID: Q9Y3A2
geneSymbol: UTP11
reactome: R-HSA-6790901;R-HSA-6791226;
length: 253
go: ENSG00000183520;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
name:
Probable U3 small nucleolar RNA-associated protein 11 (U3 snoRNA-associated protein 11) (UTP11-like protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular space [GO:0005615]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; nervous system development [GO:0007399]; positive regulation of apoptotic process [GO:0043065]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3A2-1; Sequence=Displayed; Name=2; IsoId=Q9Y3A2-2; Sequence=VSP_056872; Note=No experimental confirmation available.; 


uniprotID: Q9Y2C2
geneSymbol: UST
reactome: R-HSA-2022923;
name: Uronyl 2-sulfotransferase (EC 2.8.2.-)
length: 406
go: ENSG00000111962;
snps: rs9498146
sequence:

opentargets:
Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; sulfotransferase activity [GO:0008146]; dermatan sulfate biosynthetic process [GO:0030208]; establishment of cell polarity [GO:0030010]; protein sulfation [GO:0006477]; regulation of axonogenesis [GO:0050770]


uniprotID: Q9Y5J1
geneSymbol: UTP18
reactome: R-HSA-6790901;R-HSA-6791226;
name: U3 small nucleolar RNA-associated protein 18 homolog (WD repeat-containing protein 50)
length: 556
go: ENSG00000011260;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

opentargets:
nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]


uniprotID: P46939
geneSymbol: UTRN
pdb: 1BHD;1QAG;
name: Utrophin (Dystrophin-related protein 1) (DRP-1)
length: 3433
go: ENSG00000152818;
snps: rs12204715 rs12204734 rs35676466 rs1534443
sequence:

opentargets:
cell junction [GO:0030054]; cortical actin cytoskeleton [GO:0030864]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; dystrophin-associated glycoprotein complex [GO:0016010]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium membrane [GO:0031527]; growth cone [GO:0030426]; membrane [GO:0016020]; neuromuscular junction [GO:0031594]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; postsynaptic membrane [GO:0045211]; protein-containing complex [GO:0032991]; sarcolemma [GO:0042383]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; integrin binding [GO:0005178]; protein kinase binding [GO:0019901]; vinculin binding [GO:0017166]; zinc ion binding [GO:0008270]; muscle contraction [GO:0006936]; muscle organ development [GO:0007517]; neuromuscular junction development [GO:0007528]; positive regulation of cell-matrix adhesion [GO:0001954]; regulation of sodium ion transmembrane transporter activity [GO:2000649]; response to denervation involved in regulation of muscle adaptation [GO:0014894]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage; Named isoforms=4;  Name=1; IsoId=P46939-1; Sequence=Displayed; Name=2; IsoId=P46939-2; Sequence=VSP_047925; Note=Produced by alternative promoter usage.; Name=Up71; IsoId=P46939-3; Sequence=VSP_054943, VSP_054944; Note==Produced by alternative promoter usage. {ECO:0000305}; Name=Up140; IsoId=P46939-4; Sequence=VSP_054942; Note==Produced by alternative promoter usage.; 

location:
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Neuromuscular junction.


uniprotID: O95399
geneSymbol: UTS2
reactome: R-HSA-375276;R-HSA-416476;
name: Urotensin-2 (Urotensin II) (U-II) (UII)
length: 124
go: ENSG00000049247;
snps: rs34305100 rs2890565
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTPEELERASLLQILPEMLGAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHLLARIWKPYKKRETPDCFWKYCV

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; hormone activity [GO:0005179]; signaling receptor binding [GO:0005102]; chemical synaptic transmission [GO:0007268]; G protein-coupled receptor signaling pathway [GO:0007186]; muscle contraction [GO:0006936]; regulation of blood pressure [GO:0008217]; regulation of blood vessel diameter [GO:0097746]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95399-1; Sequence=Displayed; Name=2; IsoId=O95399-2; Sequence=VSP_013638; Note=No experimental confirmation available.; 


uniprotID: Q8IY57
geneSymbol: YAF2
reactome: R-HSA-8939243;R-HSA-8953750;
pdb: 2D9G;
name: YY1-associated factor 2
length: 180
go: ENSG00000015153;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11593398}.
sequence:
MGDKKSPTRPKRQPKPSSDEGYWDCSVCTFRNSAEAFKCMMCDVRKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDKVEKEKSEKETTSKKNSHKKTRPRLKNVDRSSAQHLEVTVGDLTVIITDFKEKTKSPPASSAASADQHSQSGSSSDNTERGMSRSSSPRGEASSLNGESH

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; negative regulation of G0 to G1 transition [GO:0070317]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8IY57-1; Sequence=Displayed; Name=2; IsoId=Q8IY57-5; Sequence=VSP_055659; Note=No experimental confirmation available.; Name=3; IsoId=Q8IY57-3; Sequence=VSP_043415; Note=No experimental confirmation available.; Name=4; IsoId=Q8IY57-4; Sequence=VSP_044598, VSP_044599; Note=No experimental confirmation available.; 


uniprotID: P30518
geneSymbol: AVPR2
reactome: R-HSA-388479;R-HSA-418555;R-HSA-432040;R-HSA-8856825;R-HSA-8856828;R-HSA-9036092;
pdb: 4JQI;
length: 371
go: ENSG00000126895;
drug: DB00872;DB00035;DB05091;DB05838;DB02638;DB06212;DB00067;
name:
Vasopressin V2 receptor (V2R) (AVPR V2) (Antidiuretic hormone receptor) (Renal-type arginine vasopressin receptor)

sequence:

opentargets:
clathrin-coated vesicle membrane [GO:0030665]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; vasopressin receptor activity [GO:0005000]; activation of adenylate cyclase activity [GO:0007190]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; cellular response to hormone stimulus [GO:0032870]; excretion [GO:0007588]; G protein-coupled receptor signaling pathway [GO:0007186]; hemostasis [GO:0007599]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; interferon-gamma production [GO:0032609]; membrane organization [GO:0061024]; negative regulation of renal sodium excretion [GO:0035814]; negative regulation of urine volume [GO:0035811]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of vasoconstriction [GO:0045907]; regulation of systemic arterial blood pressure by vasopressin [GO:0001992]; renal water homeostasis [GO:0003091]; response to cytokine [GO:0034097]; telencephalon development [GO:0021537]

snps:
rs5196 rs2071126 rs5198 rs104894759 rs193922112 rs150351033 rs104894754 rs104894760 rs104894758 rs28935496 rs796052096 rs104894747 rs104894761 rs104894756 rs104894756 rs5200 rs104894757 rs104894748 rs104894755 rs782806507 rs104894750 rs104894749 rs112109182 rs149668713 rs61733407 rs104894752 rs193922122 rs193922123 rs146350208 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P30518-1; Sequence=Displayed; Name=2; IsoId=P30518-2; Sequence=VSP_036990, VSP_036991; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23236378}; Multi-pass membrane protein {ECO:0000305}.


uniprotID: Q86TA4
name: Putative uncharacterized protein FLJ44553
length: 180
sequence:
MLEGVSNEFDHFGISLPLKICLHLGWDEGLVEGKVVRLGQGIGKSICSSCQLFEEAPTQMSTVPSGLPLPILMHLCLLPVCMAHLCPASPCYFGATPGSGKFCRLITYSHSSPQLAASLRHRGREVGKDLPYPGLCPLTFHPSFFPPVEGCVSSLPGKLLSPQTIFFQILWLYSKSSLVL


uniprotID: A8MUA0
name: Putative UPF0607 protein ENSP00000381514
length: 341
sequence:


uniprotID: P61421
geneSymbol: ATP6V0D1
reactome: R-HSA-1222556;R-HSA-381038;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 351
go: ENSG00000159720;
name:
V-type proton ATPase subunit d 1 (V-ATPase subunit d 1) (32 kDa accessory protein) (V-ATPase 40 kDa accessory protein) (V-ATPase AC39 subunit) (p39) (Vacuolar proton pump subunit d 1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; axon terminus [GO:0043679]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; plasma membrane proton-transporting V-type ATPase complex [GO:0033181]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; synaptic vesicle [GO:0008021]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; protein-containing complex binding [GO:0044877]; proton-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; brain development [GO:0007420]; cellular iron ion homeostasis [GO:0006879]; cellular response to increased oxygen levels [GO:0036295]; cilium assembly [GO:0060271]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; IRE1-mediated unfolded protein response [GO:0036498]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]; vacuolar acidification [GO:0007035]; vacuolar transport [GO:0007034]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium.


uniprotID: O15342
geneSymbol: ATP6V0E1
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
sequence: MAYHGLTVPLIVMSVFWGFVGFLVPWFIPKGPNRGVIITMLVTCSVCCYLFWLIAILAQLNPLFGPQLKNETIWYLKYHWP
length: 81
go: ENSG00000113732;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
V-type proton ATPase subunit e 1 (V-ATPase subunit e 1) (V-ATPase 9.2 kDa membrane accessory protein) (V-ATPase M9.2 subunit) (Vacuolar proton pump subunit e 1)

opentargets:
endosome membrane [GO:0010008]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; phagocytic vesicle membrane [GO:0030670]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; ATPase coupled ion transmembrane transporter activity [GO:0042625]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; transporter activity [GO:0005215]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]; transmembrane transport [GO:0055085]; vacuolar acidification [GO:0007035]


uniprotID: Q8TAA9
geneSymbol: VANGL1
name: Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1)
length: 524
go: ENSG00000173218;
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; lateral plasma membrane [GO:0016328]; multicellular organism development [GO:0007275]; pigmentation [GO:0043473]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]

snps:
rs61734296 rs146695372 rs4839469 rs201441696 rs761123443 rs121918218 rs201630629 rs121918219 rs145309218 rs121918220 rs34059106 rs775571796 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TAA9-1; Sequence=Displayed; Name=2; IsoId=Q8TAA9-2; Sequence=VSP_008742; Note=No experimental confirmation available.; 


uniprotID: P23763
geneSymbol: VAMP1
reactome: R-HSA-5250955;R-HSA-5250981;R-HSA-5250989;
name: Vesicle-associated membrane protein 1 (VAMP-1) (Synaptobrevin-1)
length: 118
go: ENSG00000139190;
drug: DB00042;
sequence:
MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVLERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYFFT

opentargets:
cell junction [GO:0030054]; cell surface [GO:0009986]; cytosol [GO:0005829]; glutamatergic synapse [GO:0098978]; integral component of plasma membrane [GO:0005887]; integral component of synaptic vesicle membrane [GO:0030285]; mitochondrial outer membrane [GO:0005741]; neuromuscular junction [GO:0031594]; neuron projection [GO:0043005]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; tertiary granule membrane [GO:0070821]; regulation of synaptic vesicle fusion to presynaptic active zone membrane [GO:0031630]; SNARE complex assembly [GO:0035493]; synaptic vesicle priming [GO:0016082]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=VAMP-1A; IsoId=P23763-1; Sequence=Displayed; Name=2; IsoId=P23763-3; Sequence=VSP_029185; Name=3; Synonyms=VAMP-1B; IsoId=P23763-2; Sequence=VSP_006325; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.; SUBCELLULAR LOCATION: Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein.


uniprotID: O95292
geneSymbol: VAPB
reactome: R-HSA-1660661;
pdb: 2MDK;3IKK;
length: 243
go: ENSG00000124164;
snps: rs281875284 rs74315431
name:
Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)

sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; beta-tubulin binding [GO:0048487]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; FFAT motif binding [GO:0033149]; microtubule binding [GO:0008017]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cellular calcium ion homeostasis [GO:0006874]; COPII-coated vesicle budding [GO:0090114]; endoplasmic reticulum organization [GO:0007029]; endoplasmic reticulum unfolded protein response [GO:0030968]; ER to Golgi vesicle-mediated transport [GO:0006888]; modulation by host of viral RNA genome replication [GO:0044830]; modulation by virus of host morphology or physiology [GO:0019048]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation by host of viral release from host cell [GO:0044790]; negative regulation by virus of viral protein levels in host cell [GO:0046725]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by host of viral release from host cell [GO:0044791]; positive regulation of viral genome replication [GO:0045070]; sphingolipid biosynthetic process [GO:0030148]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=VAP-B; IsoId=O95292-1; Sequence=Displayed; Name=2; Synonyms=VAP-C; IsoId=O95292-2; Sequence=VSP_003277, VSP_003278; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane. {ECO:0000269|PubMed:22131369}.


uniprotID: P51809
geneSymbol: VAMP7
reactome: R-HSA-421837;R-HSA-432720;R-HSA-432722;R-HSA-8856825;R-HSA-8856828;R-HSA-9020591;
pdb: 2DMW;
length: 220
go: ENSG00000124333;
name:
Vesicle-associated membrane protein 7 (VAMP-7) (Synaptobrevin-like protein 1) (Tetanus-insensitive VAMP) (Ti-VAMP)

sequence:

opentargets:
apical part of cell [GO:0045177]; azurophil granule membrane [GO:0035577]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; integral component of synaptic vesicle membrane [GO:0030285]; intracellular membrane-bounded organelle [GO:0043231]; lamellipodium [GO:0030027]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; platelet alpha granule [GO:0031091]; pseudopodium [GO:0031143]; secretory granule [GO:0030141]; secretory granule membrane [GO:0030667]; SNARE complex [GO:0031201]; trans-Golgi network [GO:0005802]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; syntaxin binding [GO:0019905]; calcium ion regulated exocytosis [GO:0017156]; endosome to lysosome transport [GO:0008333]; eosinophil degranulation [GO:0043308]; ER to Golgi vesicle-mediated transport [GO:0006888]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane organization [GO:0061024]; natural killer cell degranulation [GO:0043320]; neutrophil degranulation [GO:0043312]; phagocytosis, engulfment [GO:0006911]; positive regulation of dendrite morphogenesis [GO:0050775]; positive regulation of histamine secretion by mast cell [GO:1903595]; regulation of protein targeting to vacuolar membrane [GO:1900483]; SNARE complex assembly [GO:0035493]; triglyceride transport [GO:0034197]; vesicle fusion [GO:0006906]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle transport along microtubule [GO:0047496]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Ti-VAMPa/VAMP7a; IsoId=P51809-1; Sequence=Displayed; Name=2; Synonyms=Ti-VAMPb/VAMP7b; IsoId=P51809-2; Sequence=VSP_017509; Name=3; Synonyms=Ti-VAMPc/VAMP7c; IsoId=P51809-3; Sequence=VSP_017508; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Late endosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Single-pass type IV membrane protein {ECO:0000269|PubMed:17897319}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity). {ECO:0000250}.


uniprotID: Q96A05
geneSymbol: ATP6V1E2
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
name: V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)
length: 226
go: ENSG00000250565;
sequence:

opentargets:
acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; proton-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]


uniprotID: Q9UKW4
geneSymbol: VAV3
pdb: 2D86;
name: Guanine nucleotide exchange factor VAV3 (VAV-3)
length: 847
go: ENSG00000134215;
snps: rs34318889 rs7528153 rs12410676 rs12403266
reactome:
R-HSA-114604;R-HSA-193648;R-HSA-194840;R-HSA-2029482;R-HSA-2424491;R-HSA-2871796;R-HSA-2871809;R-HSA-3928665;R-HSA-416482;R-HSA-4420097;R-HSA-5218920;

sequence:

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; GTPase activator activity [GO:0005096]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; Rac guanyl-nucleotide exchange factor activity [GO:0030676]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; SH3/SH2 adaptor activity [GO:0005070]; angiogenesis [GO:0001525]; B cell receptor signaling pathway [GO:0050853]; cellular response to DNA damage stimulus [GO:0006974]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; integrin-mediated signaling pathway [GO:0007229]; lamellipodium assembly [GO:0030032]; neutrophil chemotaxis [GO:0030593]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cell adhesion [GO:0045785]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; response to drug [GO:0042493]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vesicle fusion [GO:0006906]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha; IsoId=Q9UKW4-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=Q9UKW4-2; Sequence=VSP_001820; Name=3; Synonyms=VAV3.1; IsoId=Q9UKW4-3; Sequence=VSP_041360, VSP_041361; Note=May be produced by alternative promoter usage.; Name=4; IsoId=Q9UKW4-4; Sequence=VSP_042359; Note=No experimental confirmation available.; 


uniprotID: P67809
geneSymbol: YBX1
reactome: R-HSA-72163;R-HSA-72165;R-HSA-9017802;
pdb: 1H95;
length: 324
go: ENSG00000065978;
name:
Nuclease-sensitive element-binding protein 1 (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Y-box transcription factor) (Y-box-binding protein 1) (YB-1)

sequence:

opentargets:
CRD-mediated mRNA stability complex [GO:0070937]; cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; histone pre-mRNA 3'end processing complex [GO:0071204]; intracellular membrane-bounded organelle [GO:0043231]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; U12-type spliceosomal complex [GO:0005689]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; double-stranded DNA binding [GO:0003690]; GTPase binding [GO:0051020]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA binding [GO:0003723]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; single-stranded DNA binding [GO:0003697]; CRD-mediated mRNA stabilization [GO:0070934]; mRNA splicing, via spliceosome [GO:0000398]; Notch signaling pathway [GO:0007219]; positive regulation of cell division [GO:0051781]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein localization to cytoplasmic stress granule [GO:1903608]; regulation of transcription, DNA-templated [GO:0006355]; transcription by RNA polymerase II [GO:0006366]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasmic granule {ECO:0000269|PubMed:25229427}. Secreted. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus. Localized with DDX1, MBNL1 and TIAL1 in stress granules upon stress. Secreted by mesangial and monocytic cells after inflammatory challenges. Translocates from the cytoplasm to the nucleus after and colocalizes with APEX1 in nuclear speckles after genotoxic stress.


uniprotID: P52735
geneSymbol: VAV2
pdb: 2DLZ;2DM1;2LNW;2LNX;4ROJ;
name: Guanine nucleotide exchange factor VAV2 (VAV-2)
length: 878
go: ENSG00000160293;
snps: rs602990
reactome:
R-HSA-114604;R-HSA-193648;R-HSA-194840;R-HSA-2029482;R-HSA-2424491;R-HSA-2871796;R-HSA-2871809;R-HSA-3928665;R-HSA-416482;R-HSA-4420097;R-HSA-445144;R-HSA-5218920;

sequence:

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; epidermal growth factor receptor binding [GO:0005154]; guanyl-nucleotide exchange factor activity [GO:0005085]; metal ion binding [GO:0046872]; phosphotyrosine residue binding [GO:0001784]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; angiogenesis [GO:0001525]; cell migration [GO:0016477]; ephrin receptor signaling pathway [GO:0048013]; Fc-epsilon receptor signaling pathway [GO:0038095]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; G protein-coupled receptor signaling pathway [GO:0007186]; lamellipodium assembly [GO:0030032]; platelet activation [GO:0030168]; positive regulation of apoptotic process [GO:0043065]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; regulation of cell size [GO:0008361]; regulation of GTPase activity [GO:0043087]; regulation of Rho protein signal transduction [GO:0035023]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P52735-1; Sequence=Displayed; Name=2; IsoId=P52735-2; Sequence=VSP_034900, VSP_034901; Name=3; IsoId=P52735-3; Sequence=VSP_034900, VSP_034901, VSP_034902; 


uniprotID: P21796
geneSymbol: VDAC1
reactome: R-HSA-1268020;R-HSA-5205685;R-HSA-5689880;R-HSA-70268;R-HSA-8949215;
pdb: 2JK4;2K4T;5JDP;5XDN;5XDO;
length: 283
go: ENSG00000213585;
drug: DB01375;
name:
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)

sequence:

opentargets:
extracellular exosome [GO:0070062]; membrane [GO:0016020]; membrane raft [GO:0045121]; mitochondrial nucleoid [GO:0042645]; mitochondrial outer membrane [GO:0005741]; mitochondrial permeability transition pore complex [GO:0005757]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; pore complex [GO:0046930]; identical protein binding [GO:0042802]; ion channel binding [GO:0044325]; porin activity [GO:0015288]; protein kinase binding [GO:0019901]; voltage-gated anion channel activity [GO:0008308]; anion transport [GO:0006820]; apoptotic process [GO:0006915]; epithelial cell differentiation [GO:0030855]; macroautophagy [GO:0016236]; pyruvate metabolic process [GO:0006090]; regulation of autophagy of mitochondrion [GO:1903146]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:7539795}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}. Cell membrane {ECO:0000269|PubMed:25168729, ECO:0000269|PubMed:25296756}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}. Membrane raft {ECO:0000269|PubMed:25168729}; Multi-pass membrane protein {ECO:0000269|PubMed:18755977, ECO:0000269|PubMed:18832158}.


uniprotID: P11473
geneSymbol: VDR
reactome: R-HSA-196791;R-HSA-383280;R-HSA-4090294;
length: 427
go: ENSG00000111424;
pdb:
1DB1;1IE8;1IE9;1KB2;1KB4;1KB6;1S0Z;1S19;1TXI;1YNW;2HAM;2HAR;2HAS;2HB7;2HB8;3A2I;3A2J;3A3Z;3A40;3A78;3AUQ;3AUR;3AX8;3AZ1;3AZ2;3AZ3;3B0T;3CS4;3CS6;3KPZ;3M7R;3OGT;3P8X;3TKC;3VHW;3W0A;3W0C;3W0Y;3WGP;3WWR;3X31;3X36;4G2I;4ITE;4ITF;5GT4;5V39;5YSY;5YT2;

name:
Vitamin D3 receptor (VDR) (1,25-dihydroxyvitamin D3 receptor) (Nuclear receptor subfamily 1 group I member 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; receptor complex [GO:0043235]; RNA polymerase II transcription factor complex [GO:0090575]; calcitriol binding [GO:1902098]; calcitriol receptor activity [GO:0008434]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; lithocholic acid binding [GO:1902121]; lithocholic acid receptor activity [GO:0038186]; nuclear receptor transcription coactivator activity [GO:0030374]; retinoid X receptor binding [GO:0046965]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; signaling receptor activity [GO:0038023]; steroid hormone receptor activity [GO:0003707]; transcription factor binding [GO:0008134]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; vitamin D binding [GO:0005499]; zinc ion binding [GO:0008270]; animal organ morphogenesis [GO:0009887]; bile acid signaling pathway [GO:0038183]; calcium ion transport [GO:0006816]; cell differentiation [GO:0030154]; cell morphogenesis [GO:0000902]; cellular calcium ion homeostasis [GO:0006874]; decidualization [GO:0046697]; intestinal absorption [GO:0050892]; lactation [GO:0007595]; mammary gland branching involved in pregnancy [GO:0060745]; multicellular organism development [GO:0007275]; negative regulation of cell proliferation [GO:0008285]; negative regulation of keratinocyte proliferation [GO:0010839]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of apoptotic process involved in mammary gland involution [GO:0060058]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vitamin D 24-hydroxylase activity [GO:0010980]; regulation of calcidiol 1-monooxygenase activity [GO:0060558]; signal transduction [GO:0007165]; skeletal system development [GO:0001501]; transcription initiation from RNA polymerase II promoter [GO:0006367]; vitamin D metabolic process [GO:0042359]; vitamin D receptor signaling pathway [GO:0070561]

drug:
DB01436;DB00146;DB02300;DB00136;DB00169;DB05024;DB01070;DB06410;DB05295;DB00153;DB04796;DB00910;DB04258;

snps:
rs121909790 rs121909797 rs121909794 rs121909791 rs121909793 rs121909795 rs11574090 rs121909796 rs121909798 rs121909799 rs267607169 rs11574115 rs121909800 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P11473-1; Sequence=Displayed; Name=2; IsoId=P11473-2; Sequence=VSP_047218; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:28698609}. Cytoplasm {ECO:0000269|PubMed:28698609}. Note=Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3. {ECO:0000269|PubMed:28698609}.


uniprotID: P15692
geneSymbol: VEGFA
name: Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF)
length: 232
go: ENSG00000112715;
drug: DB05434;DB08885;DB00112;DB01136;DB06779;DB01120;DB01017;DB03088;DB01270;DB03754;DB05294;DB05890;
reactome:
R-HSA-114608;R-HSA-1234158;R-HSA-194313;R-HSA-195399;R-HSA-4420097;R-HSA-5218921;R-HSA-6785807;R-HSA-8866910;

pdb:
1BJ1;1CZ8;1FLT;1KAT;1KMX;1MJV;1MKG;1MKK;1QTY;1TZH;1TZI;1VGH;1VPF;1VPP;2FJG;2FJH;2QR0;2VGH;2VPF;3BDY;3P9W;3QTK;3S1B;3S1K;3V2A;4DEQ;4GLN;4GLS;4KZN;4QAF;4WPB;4ZFF;5DN2;5FV1;5FV2;5HHC;5HHD;5O4E;5T89;

sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; secretory granule [GO:0030141]; chemoattractant activity [GO:0042056]; cytokine activity [GO:0005125]; extracellular matrix binding [GO:0050840]; fibronectin binding [GO:0001968]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; neuropilin binding [GO:0038191]; platelet-derived growth factor receptor binding [GO:0005161]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; receptor ligand activity [GO:0048018]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172]; activation of protein kinase activity [GO:0032147]; angiogenesis [GO:0001525]; artery morphogenesis [GO:0048844]; basophil chemotaxis [GO:0002575]; branching involved in blood vessel morphogenesis [GO:0001569]; branching morphogenesis of an epithelial tube [GO:0048754]; camera-type eye morphogenesis [GO:0048593]; cardiac muscle fiber development [GO:0048739]; cardiac vascular smooth muscle cell development [GO:0060948]; cell maturation [GO:0048469]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hypoxia [GO:0071456]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cellular stress response to acid chemical [GO:0097533]; commissural neuron axon guidance [GO:0071679]; coronary artery morphogenesis [GO:0060982]; coronary vein morphogenesis [GO:0003169]; cytokine-mediated signaling pathway [GO:0019221]; dopaminergic neuron differentiation [GO:0071542]; endothelial cell chemotaxis [GO:0035767]; epithelial cell differentiation [GO:0030855]; eye photoreceptor cell development [GO:0042462]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; induction of positive chemotaxis [GO:0050930]; kidney development [GO:0001822]; lactation [GO:0007595]; lung development [GO:0030324]; lymph vessel morphogenesis [GO:0036303]; macrophage differentiation [GO:0030225]; mammary gland alveolus development [GO:0060749]; mesoderm development [GO:0007498]; monocyte differentiation [GO:0030224]; motor neuron migration [GO:0097475]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of gene expression [GO:0010629]; negative regulation of transcription by RNA polymerase II [GO:0000122]; nervous system development [GO:0007399]; outflow tract morphogenesis [GO:0003151]; ovarian follicle development [GO:0001541]; platelet degranulation [GO:0002576]; positive chemotaxis [GO:0050918]; positive regulation of angiogenesis [GO:0045766]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis [GO:1903589]; positive regulation of branching involved in ureteric bud morphogenesis [GO:0090190]; positive regulation of cell adhesion [GO:0045785]; positive regulation of cell division [GO:0051781]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [GO:0038091]; positive regulation of cellular component movement [GO:0051272]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of CREB transcription factor activity [GO:0032793]; positive regulation of DNA biosynthetic process [GO:2000573]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of histone deacetylase activity [GO:1901727]; positive regulation of leukocyte migration [GO:0002687]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-tyrosine autophosphorylation [GO:1900086]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of phosphorylation [GO:0042327]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein kinase D signaling [GO:1903572]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of receptor internalization [GO:0002092]; positive regulation of retinal ganglion cell axon guidance [GO:1902336]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular permeability [GO:0043117]; post-embryonic camera-type eye development [GO:0031077]; primitive erythrocyte differentiation [GO:0060319]; regulation of cell shape [GO:0008360]; regulation of nitric oxide mediated signal transduction [GO:0010749]; regulation of retinal ganglion cell axon guidance [GO:0090259]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; surfactant homeostasis [GO:0043129]; tube formation [GO:0035148]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculogenesis [GO:0001570]; VEGF-activated neuropilin signaling pathway [GO:0038190]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing, Alternative initiation; Named isoforms=17;  Comment=Additional isoforms seem to exist.; Name=VEGF206; IsoId=P15692-1; Sequence=Displayed; Name=VEGF189; IsoId=P15692-2; Sequence=VSP_004622; Name=VEGF183; IsoId=P15692-3; Sequence=VSP_004621; Name=VEGF165; Synonyms=VEGF; IsoId=P15692-4; Sequence=VSP_004618, VSP_004619; Name=VEGF148; IsoId=P15692-5; Sequence=VSP_004618, VSP_004619, VSP_004624, VSP_004625; Name=VEGF145; IsoId=P15692-6; Sequence=VSP_004623; Name=VEGF165B; IsoId=P15692-8; Sequence=VSP_004618, VSP_004619, VSP_014783; Name=VEGF121; IsoId=P15692-9; Sequence=VSP_004620; Note=No experimental confirmation available.; Name=VEGF111; IsoId=P15692-10; Sequence=VSP_026781; Note=No experimental confirmation available.; Name=L-VEGF165; IsoId=P15692-11; Sequence=VSP_038745, VSP_004618, VSP_004619; Note=Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. Post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus (Ref.32), the endoplasmic reticulum and the Golgi (Ref.28) or the extracellular matrix (Ref.26). {ECO:0000305|PubMed:11563986, ECO:0000305|PubMed:11731620, ECO:0000305|PubMed:15896327}; Name=L-VEGF121; IsoId=P15692-12; Sequence=VSP_038745, VSP_004620; Note=Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. Post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus (Ref.32), the endoplasmic reticulum and the Golgi (Ref.28) or the extracellular matrix (Ref.26). {ECO:0000305|PubMed:11563986, ECO:0000305|PubMed:11731620, ECO:0000305|PubMed:15896327}; Name=L-VEGF189; IsoId=P15692-13; Sequence=VSP_038745, VSP_004622; Note=Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon. Post-translationally processed to produce the secreted VEGF peptide and a N-terminal peptide N-VEGF. The unprocessed protein and the N-VEGF peptide may localize to the nucleus (Ref.32), the endoplasmic reticulum and the Golgi (Ref.28) or the extracellular matrix (Ref.26). {ECO:0000305|PubMed:11563986, ECO:0000305|PubMed:11731620, ECO:0000305|PubMed:15896327}; Name=L-VEGF206; IsoId=P15692-14; Sequence=VSP_038745; Note=Gene prediction based on EST data. Produced by alternative promoter usage and alternative initiation. Starts at an alternative upstream CUG codon.; Name=15; IsoId=P15692-15; Sequence=VSP_038745, VSP_054111, VSP_014783; Note=Starts at an alternative upstream CUG codon.; Name=16; IsoId=P15692-16; Sequence=VSP_038745, VSP_004621; Note=Starts at an alternative upstream CUG codon.; Name=17; IsoId=P15692-17; Sequence=VSP_038745, VSP_054111, VSP_004624, VSP_004625; Note=Starts at an alternative upstream CUG codon.; Name=18; IsoId=P15692-18; Sequence=VSP_038745, VSP_026781; Note=Starts at an alternative upstream CUG codon.; 

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11563986, ECO:0000269|PubMed:11731620, ECO:0000269|PubMed:15896327}. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.


uniprotID: P16989
geneSymbol: YBX3
length: 372
go: ENSG00000060138;
snps: rs1126501
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
name:
Y-box-binding protein 3 (Cold shock domain-containing protein A) (DNA-binding protein A) (Single-strand DNA-binding protein NF-GMB)

sequence:

opentargets:
bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; double-stranded DNA binding [GO:0003690]; mRNA 3'-UTR binding [GO:0003730]; polysome binding [GO:1905538]; Rho GTPase binding [GO:0017048]; RNA binding [GO:0003723]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; transcription corepressor activity [GO:0003714]; 3'-UTR-mediated mRNA stabilization [GO:0070935]; cellular hyperosmotic response [GO:0071474]; cellular response to tumor necrosis factor [GO:0071356]; fertilization [GO:0009566]; in utero embryonic development [GO:0001701]; male gonad development [GO:0008584]; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress [GO:1902219]; negative regulation of necroptotic process [GO:0060546]; negative regulation of skeletal muscle tissue development [GO:0048642]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cytoplasmic translation [GO:2000767]; positive regulation of organ growth [GO:0046622]; response to cold [GO:0009409]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=P16989-1; Sequence=Displayed; Name=2; IsoId=P16989-2; Sequence=VSP_001135; Name=3; IsoId=P16989-3; Sequence=VSP_001136; 


uniprotID: Q99990
geneSymbol: VGLL1
name: Transcription cofactor vestigial-like protein 1 (Vgl-1) (Protein TONDU)
length: 258
go: ENSG00000102243;
snps: rs3027860
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleus [GO:0005634]; transcription coactivator activity [GO:0003713]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: Q14135
geneSymbol: VGLL4
name: Transcription cofactor vestigial-like protein 4 (Vgl-4)
length: 290
go: ENSG00000144560;
opentargets: nucleus [GO:0005634]; regulation of transcription, DNA-templated [GO:0006355]
snps: rs2276749
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q14135-1; Sequence=Displayed; Name=2; IsoId=Q14135-2; Sequence=VSP_010776; Name=3; IsoId=Q14135-3; Sequence=VSP_040213, VSP_040214; Note=Probable target of nonsense-mediated mRNA decay.; Name=4; IsoId=Q14135-4; Sequence=VSP_040212; Name=5; IsoId=Q14135-5; Sequence=VSP_040210, VSP_040216; Name=6; IsoId=Q14135-6; Sequence=VSP_040211, VSP_040215; 


uniprotID: Q6RSH7
geneSymbol: VHLL
name: von Hippel-Lindau-like protein (VHL-like protein) (VLP)
length: 139
sequence:
MPWRAGNGVGLEAQAGTQEAGPEEYCQEELGAEEEMAARAAWPVLRSVNSRELSRIIICNHSPRIVLPVWLNYYGKLLPYLTLLPGRDFRIHNFRSHPWLFRDARTHDKLLVNQTELFVPSSNVNGQPVFANITLQCIP

opentargets:
nucleus [GO:0005634]; VCB complex [GO:0030891]; ubiquitin protein ligase activity [GO:0061630]; protein ubiquitination [GO:0016567]


uniprotID: Q9BQB6
geneSymbol: VKORC1
reactome: R-HSA-6806664;
length: 163
go: ENSG00000167397;
drug: DB01418;DB00266;DB00170;DB00498;DB00946;DB00682;
snps: rs104894539 rs61742245 rs104894540 rs104894541 rs72547529 rs755767348 rs72547528 rs104894542
name:
Vitamin K epoxide reductase complex subunit 1 (EC 1.17.4.4) (Vitamin K1 2,3-epoxide reductase subunit 1)

sequence:
MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQSNSIFGCIFYTLQLLLGCLRTRWASVLMLLSSLVSLAGSVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKVQEPQGKAKRH

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; quinone binding [GO:0048038]; vitamin-K-epoxide reductase (warfarin-insensitive) activity [GO:0047058]; vitamin-K-epoxide reductase (warfarin-sensitive) activity [GO:0047057]; blood coagulation [GO:0007596]; bone development [GO:0060348]; drug metabolic process [GO:0017144]; peptidyl-glutamic acid carboxylation [GO:0017187]; regulation of blood coagulation [GO:0030193]; response to antibiotic [GO:0046677]; response to organic cyclic compound [GO:0014070]; response to organonitrogen compound [GO:0010243]; vitamin K metabolic process [GO:0042373]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=MST576; IsoId=Q9BQB6-1; Sequence=Displayed; Name=2; Synonyms=MST134; IsoId=Q9BQB6-2; Sequence=VSP_013363; Name=3; IsoId=Q9BQB6-3; Sequence=VSP_043407; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}; Multi-pass membrane protein {ECO:0000269|PubMed:14765194, ECO:0000269|PubMed:15716279, ECO:0000269|PubMed:16270630, ECO:0000269|PubMed:20978134, ECO:0000269|PubMed:22923610}.


uniprotID: Q709C8
geneSymbol: VPS13C
name: Vacuolar protein sorting-associated protein 13C
length: 3753
go: ENSG00000129003;
location: SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:26942284}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; mitochondrial outer membrane [GO:0005741]; Golgi to endosome transport [GO:0006895]; mitochondrion organization [GO:0007005]; negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization [GO:1905090]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]

snps:
rs12595158 rs3784634 rs3784635 rs2303405 rs369100678 rs8026956 rs11629598 rs11629838 rs12907567 rs34060567 rs10851704 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:15498460}; Synonyms=2A {ECO:0000269|PubMed:15498460}; IsoId=Q709C8-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15498460}; Synonyms=2B {ECO:0000269|PubMed:15498460}; IsoId=Q709C8-2; Sequence=VSP_052244, VSP_052245; Name=3 {ECO:0000269|PubMed:15498460}; Synonyms=1A {ECO:0000269|PubMed:15498460}; IsoId=Q709C8-3; Sequence=VSP_052243; Name=4 {ECO:0000269|PubMed:15498460}; Synonyms=1B {ECO:0000269|PubMed:15498460}; IsoId=Q709C8-4; Sequence=VSP_052243, VSP_052244, VSP_052245; 


uniprotID: P63124
geneSymbol: HERV-K104
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 104 Pro protein (HERV-K104 Pro protein) (HERV-K_5q13.3 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTEADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGQDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63124-1; Sequence=Displayed; 


uniprotID: P63119
geneSymbol: ERVK-21
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 21 Pro protein (HERV-K_12q14.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPTPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63119-1; Sequence=Displayed; 


uniprotID: P63129
geneSymbol: ERVK-24
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 24 Pro protein (HERV-K101 envelope protein) (HERV-K_22q11.21 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKIPFEAKINQKREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63129-1; Sequence=Displayed; 


uniprotID: Q9UN37
geneSymbol: VPS4A
reactome: R-HSA-162588;R-HSA-917729;
pdb: 1YXR;2JQ9;2K3W;
name: Vacuolar protein sorting-associated protein 4A (EC 3.6.4.6) (Protein SKD2) (VPS4-1) (hVPS4)
length: 437
go: ENSG00000132612;
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosome [GO:0005764]; midbody [GO:0030496]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; spindle pole [GO:0000922]; vacuolar membrane [GO:0005774]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, coupled [GO:0042623]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; protein-containing complex binding [GO:0044877]; abscission [GO:0009838]; actomyosin contractile ring contraction [GO:0000916]; cell division [GO:0051301]; cytoskeleton-dependent cytokinesis [GO:0061640]; endosomal transport [GO:0016197]; endosomal vesicle fusion [GO:0034058]; ESCRT complex disassembly [GO:1904896]; ESCRT III complex disassembly [GO:1904903]; intracellular cholesterol transport [GO:0032367]; late endosomal microautophagy [GO:0061738]; macroautophagy [GO:0016236]; midbody abscission [GO:0061952]; mitotic cytokinesis checkpoint [GO:0044878]; mitotic metaphase plate congression [GO:0007080]; multivesicular body assembly [GO:0036258]; negative regulation of cytokinesis [GO:0032466]; nuclear envelope organization [GO:0006998]; nuclear envelope reassembly [GO:0031468]; nucleus organization [GO:0006997]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral life cycle [GO:1903902]; positive regulation of viral release from host cell [GO:1902188]; protein targeting to lysosome [GO:0006622]; regulation of protein localization [GO:0032880]; regulation of protein localization to plasma membrane [GO:1903076]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; vesicle budding from membrane [GO:0006900]; vesicle uncoating [GO:0072319]; vesicle-mediated transport [GO:0016192]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]; viral release from host cell [GO:0019076]

location:
SUBCELLULAR LOCATION: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the midbody of dividing cells, interaction with ZFYVE19/ANCHR mediates retention at midbody (PubMed:24814515). Localized in two distinct rings on either side of the Flemming body. {ECO:0000269|PubMed:24814515}.


uniprotID: Q15849
geneSymbol: SLC14A2
reactome: R-HSA-425366;
name: Urea transporter 2 (Solute carrier family 14 member 2) (Urea transporter, kidney)
length: 920
go: ENSG00000132874;
drug: DB03904;
snps: rs34461862 rs1484873 rs35245152 rs9960464 rs1123617 rs3745009
location: SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein.
sequence:

opentargets:
apical plasma membrane [GO:0016324]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cell adhesion molecule binding [GO:0050839]; urea transmembrane transporter activity [GO:0015204]; transmembrane transport [GO:0055085]; urea transport [GO:0015840]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=UT-A1; IsoId=Q15849-1; Sequence=Displayed; Name=2; Synonyms=UT-A2; IsoId=Q15849-2; Sequence=VSP_031171; 


uniprotID: Q9NYH9
geneSymbol: UTP6
reactome: R-HSA-6790901;R-HSA-6791226;
length: 597
go: ENSG00000108651;
snps: rs16967042 rs3760454 rs34859443
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
name:
U3 small nucleolar RNA-associated protein 6 homolog (Hepatocellular carcinoma-associated antigen 66) (Multiple hat domains protein)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; rRNA processing [GO:0006364]


uniprotID: P21283
geneSymbol: ATP6V1C1
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
name: V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)
length: 382
go: ENSG00000155097;
drug: DB01694;
sequence:

opentargets:
apical part of cell [GO:0045177]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; proton-transporting two-sector ATPase complex [GO:0016469]; vacuolar proton-transporting V-type ATPase, V1 domain [GO:0000221]; proton-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; transporter activity [GO:0005215]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]


uniprotID: Q16864
geneSymbol: ATP6V1F
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 119
go: ENSG00000128524;
snps: rs10958
name:
V-type proton ATPase subunit F (V-ATPase subunit F) (V-ATPase 14 kDa subunit) (Vacuolar proton pump subunit F)

sequence:
MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting V-type ATPase, V1 domain [GO:0033180]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; ATPase activity, uncoupled [GO:0042624]; ATPase coupled ion transmembrane transporter activity [GO:0042625]; proton transmembrane transporter activity [GO:0015078]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; proton transmembrane transport [GO:1902600]; transferrin transport [GO:0033572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q16864-1; Sequence=Displayed; Name=2; IsoId=Q16864-2; Sequence=VSP_045952; Note=No experimental confirmation available.; 


uniprotID: Q96LB4
geneSymbol: ATP6V1G3
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 118
go: ENSG00000151418;
snps: rs16843254
name:
V-type proton ATPase subunit G 3 (V-ATPase subunit G 3) (V-ATPase 13 kDa subunit 3) (Vacuolar proton pump subunit G 3)

sequence:
MTSQSQGIHQLLQAEKRAKDKLEEAKKRKGKRLKQAKEEAMVEIDQYRMQRDKEFRLKQSKIMGSQNNLSDEIEEQTLGKIQELNGHYNKYMESVMNQLLSMVCDMKPEIHVNYRATN

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; ATPase binding [GO:0051117]; proton-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; transferrin transport [GO:0033572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96LB4-1; Sequence=Displayed; Name=2; IsoId=Q96LB4-2; Sequence=Not described; Name=3; IsoId=Q96LB4-3; Sequence=VSP_036423; Name=4; IsoId=Q96LB4-4; Sequence=VSP_036426; Note=No experimental confirmation available.; 


uniprotID: P27449
geneSymbol: ATP6V0C
reactome: R-HSA-1222556;R-HSA-6798695;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 155
go: ENSG00000185883;
location: SUBCELLULAR LOCATION: Vacuole membrane; Multi-pass membrane protein.
name:
V-type proton ATPase 16 kDa proteolipid subunit (V-ATPase 16 kDa proteolipid subunit) (Vacuolar proton pump 16 kDa proteolipid subunit)

sequence:
MSESKSGPEYASFFAVMGASAAMVFSALGAAYGTAKSGTGIAAMSVMRPEQIMKSIIPVVMAGIIAIYGLVVAVLIANSLNDDISLYKSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK

opentargets:
azurophil granule membrane [GO:0035577]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; ficolin-1-rich granule membrane [GO:0101003]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase, V0 domain [GO:0033179]; tertiary granule membrane [GO:0070821]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ubiquitin protein ligase binding [GO:0031625]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; neutrophil degranulation [GO:0043312]; positive regulation of Wnt signaling pathway [GO:0030177]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]; viral process [GO:0016032]


uniprotID: O43915
geneSymbol: VEGFD
reactome: R-HSA-114608;R-HSA-194313;R-HSA-195399;
pdb: 2XV7;
name: Vascular endothelial growth factor D (VEGF-D) (c-Fos-induced growth factor) (FIGF)
length: 354
go: ENSG00000165197;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; platelet-derived growth factor receptor binding [GO:0005161]; protein homodimerization activity [GO:0042803]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; vascular endothelial growth factor receptor binding [GO:0005172]; angiogenesis [GO:0001525]; cell proliferation [GO:0008283]; dopaminergic neuron differentiation [GO:0071542]; induction of positive chemotaxis [GO:0050930]; platelet degranulation [GO:0002576]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of protein phosphorylation [GO:0001934]; response to bacterium [GO:0009617]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]


uniprotID: Q6ZUG5
name: Uncharacterized protein FLJ43738
length: 572
sequence:


uniprotID: P17948
geneSymbol: FLT1
reactome: R-HSA-194306;R-HSA-195399;
pdb: 1FLT;1QSV;1QSZ;1QTY;1RV6;2XAC;3HNG;4CKV;4CL7;5ABD;5EX3;5T89;
length: 1338
go: ENSG00000102755;
snps: rs56409818 rs35073261 rs55974987 rs55687105 rs553261958 rs35549791 rs35832528
name:
Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; endosome [GO:0005768]; extracellular space [GO:0005615]; focal adhesion [GO:0005925]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; placental growth factor-activated receptor activity [GO:0036332]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; vascular endothelial growth factor-activated receptor activity [GO:0005021]; VEGF-A-activated receptor activity [GO:0036326]; VEGF-B-activated receptor activity [GO:0036327]; angiogenesis [GO:0001525]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cell migration [GO:0016477]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic morphogenesis [GO:0048598]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; negative regulation of vascular endothelial cell proliferation [GO:1905563]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of MAP kinase activity [GO:0043406]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of phosphatidylinositol 3-kinase activity [GO:0043552]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of phospholipase C activity [GO:0010863]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; protein autophosphorylation [GO:0046777]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor receptor-1 signaling pathway [GO:0036323]

drug:
DB06080;DB06626;DB06101;DB09078;DB07288;DB09079;DB05913;DB06589;DB08896;DB00398;DB01268;DB05075;DB04879;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Flt1; IsoId=P17948-1; Sequence=Displayed; Name=2; Synonyms=sFlt1; IsoId=P17948-2; Sequence=VSP_002955, VSP_002956; Name=3; Synonyms=sFlt1-14; IsoId=P17948-3; Sequence=VSP_041927, VSP_041928; Name=4; IsoId=P17948-4; Sequence=VSP_041929, VSP_041930; Name=5; Synonyms=i15; IsoId=P17948-5; Sequence=VSP_041985; Name=6; Synonyms=i18; IsoId=P17948-6; Sequence=VSP_041984; Name=7; Synonyms=i21; IsoId=P17948-7; Sequence=VSP_041983; Name=8; IsoId=P17948-8; Sequence=VSP_047759, VSP_047760; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Endosome. Note=Autophosphorylation promotes ubiquitination and endocytosis.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000269|PubMed:8248162}.; SUBCELLULAR LOCATION: Isoform 3: Secreted.; SUBCELLULAR LOCATION: Isoform 4: Secreted.; SUBCELLULAR LOCATION: Isoform 5: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 6: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 7: Cytoplasm {ECO:0000305}.


uniprotID: P35968
geneSymbol: KDR
reactome: R-HSA-194306;R-HSA-195399;R-HSA-216083;R-HSA-4420097;R-HSA-5218921;
length: 1356
go: ENSG00000128052;
pdb:
1VR2;1Y6A;1Y6B;1YWN;2M59;2MET;2MEU;2OH4;2P2H;2P2I;2QU5;2QU6;2RL5;2X1W;2X1X;2XIR;3B8Q;3B8R;3BE2;3C7Q;3CJF;3CJG;3CP9;3CPB;3CPC;3DTW;3EFL;3EWH;3KVQ;3S35;3S36;3S37;3U6J;3V2A;3V6B;3VHE;3VHK;3VID;3VNT;3VO3;3WZD;3WZE;4AG8;4AGC;4AGD;4ASD;4ASE;5EW3;5OYJ;6GQO;6GQP;6GQQ;

name:
Vascular endothelial growth factor receptor 2 (VEGFR-2) (EC 2.7.10.1) (Fetal liver kinase 1) (FLK-1) (Kinase insert domain receptor) (KDR) (Protein-tyrosine kinase receptor flk-1) (CD antigen CD309)

sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; endosome [GO:0005768]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; membrane raft [GO:0045121]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; sorting endosome [GO:0097443]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; vascular endothelial growth factor binding [GO:0038085]; vascular endothelial growth factor-activated receptor activity [GO:0005021]; angiogenesis [GO:0001525]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cell differentiation [GO:0030154]; cell migration involved in sprouting angiogenesis [GO:0002042]; cellular response to hydrogen sulfide [GO:1904881]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; embryonic hemopoiesis [GO:0035162]; endothelium development [GO:0003158]; ERK1 and ERK2 cascade [GO:0070371]; extracellular matrix organization [GO:0030198]; negative regulation of apoptotic process [GO:0043066]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of gene expression [GO:0010629]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of angiogenesis [GO:0045766]; positive regulation of blood vessel endothelial cell migration [GO:0043536]; positive regulation of cell migration [GO:0030335]; positive regulation of cell migration involved in sprouting angiogenesis [GO:0090050]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [GO:0038033]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of macroautophagy [GO:0016239]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of phosphatidylinositol 3-kinase signaling [GO:0014068]; positive regulation of positive chemotaxis [GO:0050927]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vasculogenesis [GO:2001214]; protein autophosphorylation [GO:0046777]; protein kinase B signaling [GO:0043491]; regulation of cell shape [GO:0008360]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vasculogenesis [GO:0001570]; viral process [GO:0016032]

drug:
DB07528;DB06938;DB06080;DB06626;DB04849;DB08875;DB05198;DB06101;DB09078;DB07183;DB09079;DB06589;DB08901;DB05578;DB08896;DB00398;DB01268;DB05075;DB04879;DB05153;DB05146;DB05030;DB05014;

snps:
rs35636987 rs2305948 rs56286620 rs1870377 rs34231037 rs55716939 rs34038364 rs35603373 rs1139776 rs13129474 rs56302315 rs121917766 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=mbVegfr-2; IsoId=P35968-1; Sequence=Displayed; Name=2; Synonyms=sVegfr-2; IsoId=P35968-2; Sequence=VSP_041988, VSP_041989; Name=3; Synonyms=VEGFR2-712; IsoId=P35968-3; Sequence=VSP_041990, VSP_041991; 

location:
SUBCELLULAR LOCATION: Cell junction {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:23529610}. Note=Localized with RAP1A at cell-cell junctions (By similarity). Colocalizes with ERN1 and XBP1 in the endoplasmic reticulum in endothelial cells in a vascular endothelial growth factor (VEGF)-dependent manner (PubMed:23529610). {ECO:0000250, ECO:0000269|PubMed:23529610}.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm. Nucleus. Cytoplasmic vesicle. Early endosome. Note=Detected on caveolae-enriched lipid rafts at the cell surface. Is recycled from the plasma membrane to endosomes and back again. Phosphorylation triggered by VEGFA binding promotes internalization and subsequent degradation. VEGFA binding triggers internalization and translocation to the nucleus.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Secreted.


uniprotID: P35916
geneSymbol: FLT4
reactome: R-HSA-195399;R-HSA-9013695;
pdb: 4BSJ;4BSK;
length: 1363
go: ENSG00000037280;
drug: DB06080;DB06626;DB06101;DB09078;DB09079;DB06589;DB08896;DB00398;DB01268;DB05075;DB04879;
name:
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; growth factor binding [GO:0019838]; protein homodimerization activity [GO:0042803]; protein phosphatase binding [GO:0019903]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; vascular endothelial growth factor-activated receptor activity [GO:0005021]; VEGF-C-activated receptor activity [GO:0036328]; blood vessel morphogenesis [GO:0048514]; cell differentiation [GO:0030154]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; lung alveolus development [GO:0048286]; lymph vessel development [GO:0001945]; lymphangiogenesis [GO:0001946]; negative regulation of apoptotic process [GO:0043066]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine phosphorylation [GO:0018108]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein kinase C signaling [GO:0090037]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor production [GO:0010575]; protein autophosphorylation [GO:0046777]; regulation of blood vessel remodeling [GO:0060312]; respiratory system process [GO:0003016]; sprouting angiogenesis [GO:0002040]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]; vasculature development [GO:0001944]

snps:
rs34221241 rs372947534 rs307826 rs35874891 rs55667289 rs121909657 rs267606818 rs35171798 rs121909654 rs448012 rs34255532 rs56082504 rs121909653 rs121909650 rs121909651 rs56310180 rs121909655 rs121909656 rs121909652 rs1130379 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Long; IsoId=P35916-2; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P35916-1; Sequence=VSP_041995; Name=3; Synonyms=sVegfr3; IsoId=P35916-3; Sequence=VSP_041993, VSP_041994; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:7898938}; Single-pass type I membrane protein. Cytoplasm {ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:20445537}. Nucleus {ECO:0000269|PubMed:16452200}. Note=Ligand-mediated autophosphorylation leads to rapid internalization. {ECO:0000269|PubMed:20445537}.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Ligand-mediated autophosphorylation leads to rapid internalization.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Secreted. Cytoplasm.


uniprotID: O15240
geneSymbol: VGF
reactome: R-HSA-381426;R-HSA-8957275;
length: 615
go: ENSG00000128564;
name:
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); Antimicrobial peptide VGF[554-577]]

sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; endoplasmic reticulum lumen [GO:0005788]; extracellular space [GO:0005615]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; transport vesicle [GO:0030133]; growth factor activity [GO:0008083]; neuropeptide hormone activity [GO:0005184]; cellular protein metabolic process [GO:0044267]; defense response to bacterium [GO:0042742]; generation of precursor metabolites and energy [GO:0006091]; glucose homeostasis [GO:0042593]; insulin secretion [GO:0030073]; ovarian follicle development [GO:0001541]; post-translational protein modification [GO:0043687]; response to cAMP [GO:0051591]; response to cold [GO:0009409]; response to dietary excess [GO:0002021]; response to insulin [GO:0032868]; sexual reproduction [GO:0019953]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19194657}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:19194657}. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.


uniprotID: Q8N8G2
geneSymbol: VGLL2
name: Transcription cofactor vestigial-like protein 2 (Vgl-2) (Protein VITO1)
length: 317
go: ENSG00000170162;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; protein C-terminus binding [GO:0008022]; transcription coactivator activity [GO:0003713]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal muscle tissue development [GO:0007519]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N8G2-1; Sequence=Displayed; Name=2; IsoId=Q8N8G2-2; Sequence=VSP_032166; 


uniprotID: A8MV65
geneSymbol: VGLL3
name: Transcription cofactor vestigial-like protein 3 (Vgl-3)
length: 326
go: ENSG00000206538;
opentargets: nucleus [GO:0005634]; regulation of transcription by RNA polymerase II [GO:0006357]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N8G2}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A8MV65-1; Sequence=Displayed; Note=Gene prediction based on EST data. {ECO:0000305}; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=A8MV65-2; Sequence=VSP_052713; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q9P2U7
geneSymbol: SLC17A7
reactome: R-HSA-210500;R-HSA-428643;
length: 560
go: ENSG00000104888;
snps: rs17855709
name:
Vesicular glutamate transporter 1 (VGluT1) (Brain-specific Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 7)

sequence:

opentargets:
cell junction [GO:0030054]; cerebellar mossy fiber [GO:0044300]; clathrin-sculpted glutamate transport vesicle membrane [GO:0060203]; excitatory synapse [GO:0060076]; integral component of membrane [GO:0016021]; integral component of synaptic vesicle membrane [GO:0030285]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynaptic active zone [GO:0048786]; synaptic vesicle membrane [GO:0030672]; extracellularly glutamate-gated chloride channel activity [GO:0008068]; L-glutamate transmembrane transporter activity [GO:0005313]; neurotransmitter transporter activity [GO:0005326]; sodium-dependent phosphate transmembrane transporter activity [GO:0015321]; sodium:inorganic phosphate symporter activity [GO:0015319]; brain development [GO:0007420]; glutamate secretion [GO:0014047]; ion transport [GO:0006811]; L-glutamate import [GO:0051938]; long-term memory [GO:0007616]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; phosphate ion transport [GO:0006817]; regulation of synaptic vesicle endocytosis [GO:1900242]; sequestering of neurotransmitter [GO:0042137]; synaptic transmission, glutamatergic [GO:0035249]; synaptic vesicle lumen acidification [GO:0097401]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9P2U7-1; Sequence=Displayed; Name=2; IsoId=Q9P2U7-2; Sequence=VSP_056110; Note=No experimental confirmation available.; Name=3; IsoId=Q9P2U7-3; Sequence=VSP_056111; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q3TXX4}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q3TXX4}.


uniprotID: Q9P2U8
geneSymbol: SLC17A6
reactome: R-HSA-428643;
length: 582
go: ENSG00000091664;
snps: rs7117340
name:
Vesicular glutamate transporter 2 (VGluT2) (Differentiation-associated BNPI) (Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter) (Solute carrier family 17 member 6)

sequence:

opentargets:
cell junction [GO:0030054]; excitatory synapse [GO:0060076]; integral component of membrane [GO:0016021]; integral component of synaptic vesicle membrane [GO:0030285]; neuron projection [GO:0043005]; synaptic vesicle membrane [GO:0030672]; L-glutamate transmembrane transporter activity [GO:0005313]; neurotransmitter transporter activity [GO:0005326]; symporter activity [GO:0015293]; ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sodium ion transport [GO:0006814]; synaptic transmission, glutamatergic [GO:0035249]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8BLE7}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q8BLE7}.


uniprotID: Q8NDX2
geneSymbol: SLC17A8
reactome: R-HSA-428643;R-HSA-5619076;
name: Vesicular glutamate transporter 3 (VGluT3) (Solute carrier family 17 member 8)
length: 589
go: ENSG00000179520;
snps: rs45610843 rs121918339 rs11568530 rs11568543
sequence:

opentargets:
apical dendrite [GO:0097440]; axon terminus [GO:0043679]; basal dendrite [GO:0097441]; cell junction [GO:0030054]; excitatory synapse [GO:0060076]; glial limiting end-foot [GO:0097451]; integral component of membrane [GO:0016021]; integral component of synaptic vesicle membrane [GO:0030285]; multivesicular body [GO:0005771]; pericellular basket [GO:1990030]; perikaryon [GO:0043204]; synaptic vesicle membrane [GO:0030672]; L-glutamate transmembrane transporter activity [GO:0005313]; neurotransmitter transporter activity [GO:0005326]; symporter activity [GO:0015293]; brain development [GO:0007420]; cochlea development [GO:0090102]; ion transport [GO:0006811]; neural retina development [GO:0003407]; neurotransmitter loading into synaptic vesicle [GO:0098700]; sensory perception of sound [GO:0007605]; sodium ion transport [GO:0006814]; synaptic transmission, glutamatergic [GO:0035249]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NDX2-1; Sequence=Displayed; Name=2; IsoId=Q8NDX2-2; Sequence=VSP_033265; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q7TSF2}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:Q7TSF2}.


uniprotID: Q9H598
geneSymbol: SLC32A1
reactome: R-HSA-425393;R-HSA-888590;
length: 525
go: ENSG00000101438;
drug: DB00145;
snps: rs34517228
name:
Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) (hVIAAT)

sequence:

opentargets:
cell tip [GO:0051286]; clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202]; cone cell pedicle [GO:0044316]; dendrite [GO:0030425]; dendrite terminus [GO:0044292]; GABA-ergic synapse [GO:0098982]; inhibitory synapse [GO:0060077]; integral component of synaptic vesicle membrane [GO:0030285]; neuron projection [GO:0043005]; neuron projection terminus [GO:0044306]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; synaptic vesicle membrane [GO:0030672]; amino acid transmembrane transporter activity [GO:0015171]; gamma-aminobutyric acid:proton symporter activity [GO:0015495]; glycine transmembrane transporter activity [GO:0015187]; aging [GO:0007568]; amino acid transmembrane transport [GO:0003333]; hippocampus development [GO:0021766]; ion transport [GO:0006811]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter secretion [GO:0007269]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O35458}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q00341
geneSymbol: HDLBP
reactome: R-HSA-8964011;
pdb: 1VIG;1VIH;2CTE;2CTF;2CTJ;2CTK;2CTL;2CTM;
name: Vigilin (High density lipoprotein-binding protein) (HDL-binding protein)
length: 1268
snps: rs11891776 rs7572799 rs7578199 rs12281
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8605996}. Nucleus {ECO:0000269|PubMed:8605996}.
sequence:

opentargets:
cytosol [GO:0005829]; high-density lipoprotein particle [GO:0034364]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; lipid binding [GO:0008289]; RNA binding [GO:0003723]; cholesterol metabolic process [GO:0008203]; high-density lipoprotein particle clearance [GO:0034384]; lipid transport [GO:0006869]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q00341-1; Sequence=Displayed; Name=2; IsoId=Q00341-2; Sequence=VSP_044924, VSP_044925; Note=No experimental confirmation available.; 


uniprotID: P09327
geneSymbol: VIL1
pdb: 1UNC;3FG7;
name: Villin-1
length: 827
go: ENSG00000127831;
snps: rs35305540
sequence:

opentargets:
actin filament bundle [GO:0032432]; brush border [GO:0005903]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; filopodium tip [GO:0032433]; lamellipodium [GO:0030027]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; cysteine-type endopeptidase inhibitor activity involved in apoptotic process [GO:0043027]; identical protein binding [GO:0042802]; lysophosphatidic acid binding [GO:0035727]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein homodimerization activity [GO:0042803]; actin filament capping [GO:0051693]; actin filament depolymerization [GO:0030042]; actin filament polymerization [GO:0030041]; actin filament severing [GO:0051014]; actin nucleation [GO:0045010]; barbed-end actin filament capping [GO:0051016]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to hepatocyte growth factor stimulus [GO:0035729]; cytoplasmic actin-based contraction involved in cell motility [GO:0060327]; epidermal growth factor receptor signaling pathway [GO:0007173]; epithelial cell differentiation [GO:0030855]; intestinal D-glucose absorption [GO:0001951]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of actin filament depolymerization [GO:0030836]; positive regulation of cell migration [GO:0030335]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of lamellipodium morphogenesis [GO:2000394]; positive regulation of multicellular organism growth [GO:0040018]; positive regulation of protein localization to plasma membrane [GO:1903078]; protein-containing complex assembly [GO:0065003]; regulation of actin nucleation [GO:0051125]; regulation of cell shape [GO:0008360]; regulation of lamellipodium morphogenesis [GO:2000392]; regulation of microvillus length [GO:0032532]; regulation of wound healing [GO:0061041]; response to bacterium [GO:0009617]; terminal web assembly [GO:1902896]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P09327-1; Sequence=Displayed; Name=2; IsoId=P09327-2; Sequence=VSP_054436, VSP_054437; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cell projection, microvillus. Cell projection, filopodium tip {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Relocalized in the tip of cellular protrusions and filipodial extensions upon infection with S.flexneri in primary intestinal epithelial cells (IEC) and in the tail-like structures forming the actin comets of S.flexneri. Redistributed to the leading edge of hepatocyte growth factor (HGF)-induced lamellipodia (By similarity). Rapidly redistributed to ruffles and lamellipodia structures in response to autotaxin, lysophosphatidic acid (LPA) and epidermal growth factor (EGF) treatment. {ECO:0000250}.


uniprotID: Q6PFW1
geneSymbol: PPIP5K1
reactome: R-HSA-1855167;
length: 1433
go: ENSG00000168781;
name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 1) (Histidine acid phosphatase domain-containing protein 2A) (IP6 kinase) (Inositol pyrophosphate synthase 1) (InsP6 and PP-IP5 kinase 1) (VIP1 homolog) (hsVIP1)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; 5-diphosphoinositol pentakisphosphate 3-kinase activity [GO:0102092]; ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=Q6PFW1-1; Sequence=Displayed; Name=2; IsoId=Q6PFW1-2; Sequence=VSP_030618, VSP_030622; Name=3; IsoId=Q6PFW1-3; Sequence=VSP_030618, VSP_030621; Name=4; IsoId=Q6PFW1-4; Sequence=VSP_030615, VSP_030618, VSP_030621; Name=5; IsoId=Q6PFW1-5; Sequence=VSP_030616, VSP_030619, VSP_030623; Name=6; IsoId=Q6PFW1-6; Sequence=VSP_030617; Note=No experimental confirmation available.; Name=7; IsoId=Q6PFW1-7; Sequence=VSP_030618, VSP_030620, VSP_030624; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752, ECO:0000269|PubMed:21222653}. Cell membrane {ECO:0000269|PubMed:21222653}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000269|PubMed:21222653}.


uniprotID: P32241
geneSymbol: VIPR1
reactome: R-HSA-418555;R-HSA-420092;
pdb: 1OF2;1OGT;3B3I;3B6S;3DTX;3HCV;5DEF;5DEG;5IB1;5IB2;5IB3;5IB4;5IB5;
length: 457
go: ENSG00000114812;
snps: rs17855906 rs3733055
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Vasoactive intestinal polypeptide receptor 1 (VIP-R-1) (Pituitary adenylate cyclase-activating polypeptide type II receptor) (PACAP type II receptor) (PACAP-R-2) (PACAP-R2) (VPAC1)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; G protein-coupled peptide receptor activity [GO:0008528]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [GO:0007187]; positive regulation of cell proliferation [GO:0008284]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=Short; Synonyms=hIVR8; IsoId=P32241-1; Sequence=Displayed; Name=Long; Synonyms=hIVR5; IsoId=P32241-2; Sequence=VSP_002010; Name=3; IsoId=P32241-3; Sequence=VSP_045143; Name=4; IsoId=P32241-4; Sequence=VSP_047271, VSP_047273; Name=5; IsoId=P32241-5; Sequence=VSP_047272; 


uniprotID: Q6UXI7
geneSymbol: VIT
name: Vitrin
length: 678
go: ENSG00000205221;
snps: rs2072526 rs2072525 rs11901202
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; interstitial matrix [GO:0005614]; glycosaminoglycan binding [GO:0005539]; extracellular matrix organization [GO:0030198]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; positive regulation of cell-substrate adhesion [GO:0010811]; spinal cord development [GO:0021510]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q6UXI7-1; Sequence=Displayed; Name=2; IsoId=Q6UXI7-2; Sequence=VSP_020211; Name=3; IsoId=Q6UXI7-3; Sequence=VSP_020209, VSP_020210; Name=4; IsoId=Q6UXI7-4; Sequence=VSP_040124; Name=5; IsoId=Q6UXI7-5; Sequence=VSP_044597; Note=No experimental confirmation available.; 


uniprotID: Q9P2Y5
geneSymbol: UVRAG
reactome: R-HSA-1632852;
name: UV radiation resistance-associated gene protein (p63)
length: 699
go: ENSG00000198382;
snps: rs7118567
sequence:

opentargets:
centrosome [GO:0005813]; chromosome, centromeric region [GO:0000775]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; late endosome [GO:0005770]; lysosome [GO:0005764]; midbody [GO:0030496]; phagocytic vesicle [GO:0045335]; protein-containing complex [GO:0032991]; SH3 domain binding [GO:0017124]; SNARE binding [GO:0000149]; autophagy [GO:0006914]; centrosome cycle [GO:0007098]; chromosome segregation [GO:0007059]; DNA repair [GO:0006281]; double-strand break repair via classical nonhomologous end joining [GO:0097680]; maintenance of Golgi location [GO:0051684]; multivesicular body sorting pathway [GO:0071985]; positive regulation of autophagosome maturation [GO:1901098]; receptor catabolic process [GO:0032801]; regulation of cytokinesis [GO:0032465]; regulation of protein serine/threonine kinase activity [GO:0071900]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]; SNARE complex assembly [GO:0035493]; spindle organization [GO:0007051]; viral entry into host cell [GO:0046718]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9P2Y5-1; Sequence=Displayed; Name=2; IsoId=Q9P2Y5-2; Sequence=VSP_056176; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:18843052}. Lysosome {ECO:0000269|PubMed:18843052}. Early endosome {ECO:0000269|PubMed:18552835, ECO:0000269|PubMed:18843052}. Endoplasmic reticulum {ECO:0000269|PubMed:24056303}. Midbody {ECO:0000269|PubMed:20643123}. Chromosome, centromere {ECO:0000269|PubMed:22542840}. Note=Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial.


uniprotID: Q9Y5K8
geneSymbol: ATP6V1D
reactome: R-HSA-1222556;R-HSA-6798695;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 247
go: ENSG00000100554;
name:
V-type proton ATPase subunit D (V-ATPase subunit D) (V-ATPase 28 kDa accessory protein) (Vacuolar proton pump subunit D)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; plasma membrane [GO:0005886]; proton-transporting V-type ATPase complex [GO:0033176]; specific granule membrane [GO:0035579]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; cilium assembly [GO:0060271]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; neutrophil degranulation [GO:0043312]; protein localization to cilium [GO:0061512]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Note=Localizes to centrosome and the base of the cilium.


uniprotID: O75348
geneSymbol: ATP6V1G1
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 118
go: ENSG00000136888;
name:
V-type proton ATPase subunit G 1 (V-ATPase subunit G 1) (V-ATPase 13 kDa subunit 1) (Vacuolar proton pump subunit G 1) (Vacuolar proton pump subunit M16)

sequence:
MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; vacuolar proton-transporting V-type ATPase complex [GO:0016471]; ATPase binding [GO:0051117]; proton-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; cellular iron ion homeostasis [GO:0006879]; cellular response to increased oxygen levels [GO:0036295]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]


uniprotID: Q96JH7
geneSymbol: VCPIP1
reactome: R-HSA-5689896;
length: 1222
go: ENSG00000175073;
name:
Deubiquitinating protein VCIP135 (EC 3.4.19.12) (Valosin-containing protein p97/p47 complex-interacting protein 1) (Valosin-containing protein p97/p47 complex-interacting protein p135) (VCP/p47 complex-interacting 135-kDa protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum lumen [GO:0005788]; Golgi stack [GO:0005795]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; endoplasmic reticulum membrane fusion [GO:0016320]; Golgi reassembly [GO:0090168]; mitotic cell cycle [GO:0000278]; protein K11-linked deubiquitination [GO:0035871]; protein K48-linked deubiquitination [GO:0071108]; protein ubiquitination [GO:0016567]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Golgi apparatus, Golgi stack {ECO:0000250}. Note=Associated with Golgi stacks and endoplasmic reticulum. {ECO:0000250}.


uniprotID: Q9HBM0
geneSymbol: VEZT
name: Vezatin
length: 779
go: ENSG00000028203;
snps: rs17855933 rs10507051 rs17344738 rs17855934 rs14121
sequence:

opentargets:
acrosomal vesicle [GO:0001669]; adherens junction [GO:0005912]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; myosin binding [GO:0017022]; cell-cell adhesion [GO:0098609]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q9HBM0-1; Sequence=Displayed; Name=2; IsoId=Q9HBM0-2; Sequence=VSP_004010, VSP_004011, VSP_004014, VSP_004017; Note=Due to intron retention.; Name=5; IsoId=Q9HBM0-5; Sequence=VSP_040854, VSP_040855; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; IsoId=Q9HBM0-6; Sequence=VSP_040853, VSP_040856; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.


uniprotID: Q1RN00
name: Putative uncharacterized protein LOC151760
length: 199
sequence:
MLPVQRRKLDPLLKKYRHHKKATRTKRRRKEKMEAQCSPVPPTPSTPPQSEEDEAVDKKPTLLSAQEDTPDLLHEDRLQYLQEEGSGVMHQECQIQSCELSVAQKPRPSSPAVTSLASPPLCFGSFLSCVCQTFSRSRKQKPPRRKGNNQAEAGGDAEVLRPGPAKPELSLSKTCSHLKLIELSFVFSFIVLSVCHCSS


uniprotID: P40337
geneSymbol: VHL
reactome: R-HSA-1234176;R-HSA-3232142;R-HSA-8951664;R-HSA-983168;
name: von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
length: 213
go: ENSG00000134086;
pdb:
1LM8;1LQB;1VCB;3ZRC;3ZRF;3ZTC;3ZTD;3ZUN;4AJY;4AWJ;4B95;4B9K;4BKS;4BKT;4W9C;4W9D;4W9E;4W9F;4W9G;4W9H;4W9I;4W9J;4W9K;4W9L;4WQO;5LLI;5N4W;5NVV;5NVW;5NVX;5NVY;5NVZ;5NW0;5NW1;5NW2;5T35;6BVB;6FMI;6FMJ;6FMK;6GFX;6GFY;6GFZ;6GMN;6GMQ;6GMR;6GMX;

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; VCB complex [GO:0030891]; enzyme binding [GO:0019899]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; cell morphogenesis [GO:0000902]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell proliferation [GO:0008285]; negative regulation of gene expression [GO:0010629]; negative regulation of JAK-STAT cascade [GO:0046426]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061428]; positive regulation of cell differentiation [GO:0045597]; positive regulation of transcription, DNA-templated [GO:0045893]; post-translational protein modification [GO:0043687]; protein stabilization [GO:0050821]; protein ubiquitination [GO:0016567]; proteolysis [GO:0006508]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; regulation of transcription, DNA-templated [GO:0006355]

snps:
rs35460768 rs373068386 rs104893827 rs104893826 rs869025616 rs5030826 rs5030826 rs5030802 rs5030803 rs730882033 rs5030804 rs5030804 rs5030805 rs5030805 rs104893829 rs794726890 rs5030827 rs398123481 rs730882034 rs730882034 rs398123481 rs119103277 rs5030807 rs5030807 rs1060503563 rs5030808 rs5030808 rs5030809 rs397516440 rs193922609 rs17855706 rs869025631 rs765978945 rs104893824 rs104893824 rs869025636 rs5030812 rs5030811 rs727504215 rs5030830 rs5030832 rs104893831 rs104893830 rs1064794272 rs119103278 rs5030833 rs5030833 rs771727849 rs1060503555 rs587780077 rs869025659 rs397516441 rs869025660 rs121913346 rs5030818 rs730882035 rs397516444 rs869025662 rs397516444 rs28940297 rs267607170 rs104893825 rs5030820 rs5030821 rs5030820 rs5030822 rs377715747 rs1064793878 rs367545984 rs5030824 rs28940301 rs28940300 rs28940298 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing, Alternative initiation; Named isoforms=3;  Name=1; Synonyms=VHL30, VHLp24(MPR); IsoId=P40337-1; Sequence=Displayed; Note=Major isoform.; Name=2; IsoId=P40337-2; Sequence=VSP_004488; Name=3; Synonyms=VHL19, VHLp18(MEA); IsoId=P40337-3; Sequence=VSP_007740; Note=Produced by alternative initiation at Met-54 of isoform 1.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Note=Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus. Note=Equally distributed between the nucleus and the cytoplasm but not membrane-associated.


uniprotID: O43314
geneSymbol: PPIP5K2
reactome: R-HSA-1855167;
pdb: 3T54;3T7A;3T99;3T9A;3T9B;3T9C;3T9D;3T9E;3T9F;4HN2;4NZM;4NZN;4NZO;4Q4C;4Q4D;5BYA;5BYB;5DGH;5DGI;
length: 1243
go: ENSG00000145725;
snps: rs17155115 rs12519525 rs12520040 rs17155138 rs17155147
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17690096}.
name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.21) (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)

sequence:

opentargets:
cytosol [GO:0005829]; 5-diphosphoinositol pentakisphosphate 3-kinase activity [GO:0102092]; ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexakisphosphate 1-kinase activity [GO:0052723]; inositol hexakisphosphate 3-kinase activity [GO:0052724]; inositol hexakisphosphate 5-kinase activity [GO:0000832]; inositol hexakisphosphate kinase activity [GO:0000828]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43314-1; Sequence=Displayed; Name=2; IsoId=O43314-2; Sequence=VSP_030636; Note=No experimental confirmation available.; 


uniprotID: P41587
geneSymbol: VIPR2
reactome: R-HSA-418555;R-HSA-420092;
pdb: 2X57;
length: 438
go: ENSG00000106018;
snps: rs1062609 rs1042620
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; peptide hormone binding [GO:0017046]; vasoactive intestinal polypeptide receptor activity [GO:0004999]; activation of adenylate cyclase activity [GO:0007190]; cell surface receptor signaling pathway [GO:0007166]; cell-cell signaling [GO:0007267]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of smooth muscle cell proliferation [GO:0048662]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P41587-1; Sequence=Displayed; Name=2; IsoId=P41587-2; Sequence=VSP_056684, VSP_056685; Note=No experimental confirmation available.; 


uniprotID: P01282
geneSymbol: VIP
reactome: R-HSA-418555;R-HSA-420092;
pdb: 2RRH;2RRI;
length: 170
go: ENSG00000146469;
location: SUBCELLULAR LOCATION: Secreted.
name:
VIP peptides [Cleaved into: Intestinal peptide PHV-42 (Peptide histidine valine 42); Intestinal peptide PHM-27 (Peptide histidine methioninamide 27); Vasoactive intestinal peptide (VIP) (Vasoactive intestinal polypeptide)]

sequence:
MDTRNKAQLLVLLTLLSVLFSQTSAWPLYRAPSALRLGDRIPFEGANEPDQVSLKEDIDMLQNALAENDTPYYDVSRNARHADGVFTSDFSKLLGQLSAKKYLESLMGKRVSSNISEDPVPVKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK

opentargets:
extracellular region [GO:0005576]; intracellular [GO:0005622]; neuron projection [GO:0043005]; perikaryon [GO:0043204]; hormone activity [GO:0005179]; neuropeptide hormone activity [GO:0005184]; peptide hormone receptor binding [GO:0051428]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; body fluid secretion [GO:0007589]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; epinephrine secretion [GO:0048242]; G protein-coupled receptor signaling pathway [GO:0007186]; innate immune response [GO:0045087]; learning or memory [GO:0007611]; mRNA stabilization [GO:0048255]; negative regulation of apoptotic process [GO:0043066]; negative regulation of potassium ion transport [GO:0043267]; negative regulation of smooth muscle cell proliferation [GO:0048662]; positive regulation of blood vessel diameter [GO:0097755]; positive regulation of cell proliferation [GO:0008284]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epinephrine secretion [GO:0032812]; positive regulation of penile erection [GO:0060406]; positive regulation of protein catabolic process [GO:0045732]; prolactin secretion [GO:0070459]; regulation of protein localization [GO:0032880]; regulation of sensory perception of pain [GO:0051930]; response to yeast [GO:0001878]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P01282-1; Sequence=Displayed; Name=2; IsoId=P01282-2; Sequence=VSP_023256; 


uniprotID: Q5THJ4
geneSymbol: VPS13D
name: Vacuolar protein sorting-associated protein 13D
length: 4388
go: ENSG00000048707;
snps: rs12057307 rs12407578 rs4845898 rs41279454 rs958068
sequence:

opentargets:
extracellular exosome [GO:0070062]; extrinsic component of membrane [GO:0019898]; intracellular [GO:0005622]; protein retention in Golgi apparatus [GO:0045053]; protein targeting to vacuole [GO:0006623]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1 {ECO:0000269|PubMed:15498460}; Synonyms=1A {ECO:0000269|PubMed:15498460}; IsoId=Q5THJ4-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:15498460}; Synonyms=2A {ECO:0000269|PubMed:15498460}; IsoId=Q5THJ4-2; Sequence=VSP_052249; 


uniprotID: O75436
geneSymbol: VPS26A
reactome: R-HSA-3238698;
pdb: 2FAU;5F0J;5F0L;5F0M;5F0P;
name: Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26)
length: 327
go: ENSG00000122958;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; lysosome [GO:0005764]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; vesicle [GO:0031982]; protein transporter activity [GO:0008565]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, endosome to plasma membrane [GO:1990126]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75436-1; Sequence=Displayed; Name=2; IsoId=O75436-2; Sequence=VSP_044910; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15078903}. Endosome membrane {ECO:0000269|PubMed:22431521}; Peripheral membrane protein {ECO:0000250|UniProtKB:P40336}. Early endosome {ECO:0000269|PubMed:15078903, ECO:0000269|PubMed:16190980, ECO:0000269|PubMed:16732284, ECO:0000269|PubMed:20682791}. Note=Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity). {ECO:0000250|UniProtKB:P40336}.


uniprotID: Q4G0F5
geneSymbol: VPS26B
name: Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B)
length: 336
go: ENSG00000151502;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; late endosome [GO:0005770]; phagocytic vesicle [GO:0045335]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; protein transporter activity [GO:0008565]; cellular response to interferon-gamma [GO:0071346]; intracellular protein transport [GO:0006886]; regulation of macroautophagy [GO:0016241]; retrograde transport, endosome to Golgi [GO:0042147]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}. Early endosome {ECO:0000250|UniProtKB:Q8C0E2}. Late endosome {ECO:0000250|UniProtKB:Q8C0E2}. Note=Localizes to early and late endosomal structures (By similarity). {ECO:0000250|UniProtKB:Q8C0E2}.


uniprotID: P63120
geneSymbol: ERVK-19
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 19 Pro protein (HERV-K(C19) Pro protein) (HERV-K_19q12 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPLYSPTSQKIMTKMGYILGKGLGKNEDGIKIPVEAKINQKREGIGYPF

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=P63120-1; Sequence=Displayed; 


uniprotID: Q9UKI3
geneSymbol: VPREB3
reactome: R-HSA-202733;
name: Pre-B lymphocyte protein 3 (N27C7-2) (Protein VPreB3)
length: 123
go: ENSG00000128218;
snps: rs34372784
sequence:
MACRCLSFLLMGTFLSVSQTVLAQLDALLVFPGQVAQLSCTLSPQHVTIRDYGVSWYQQRAGSAPRYLLYYRSEEDHHRPADIPDRFSAAKDEAHNACVLTISPVQPEDDADYYCSVGYGFSP

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; immune response [GO:0006955]; immunoglobulin production [GO:0002377]; leukocyte migration [GO:0050900]


uniprotID: P11684
geneSymbol: SCGB1A1
sequence: MKLAVTLTLVTLALCCSSASAEICPSFQRVIETLLMDTPSSYEAAMELFSPDQDMREAGAQLKKLVDTLPQKPRESIIKLMEKIAQSSLCN
length: 91
go: ENSG00000149021;
snps: rs1802634 rs1802632
location: SUBCELLULAR LOCATION: Secreted.
name:
Uteroglobin (Clara cell phospholipid-binding protein) (CCPBP) (Clara cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1)

opentargets:
extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; nuclear envelope [GO:0005635]; rough endoplasmic reticulum [GO:0005791]; secretory granule [GO:0030141]; phospholipase A2 inhibitor activity [GO:0019834]; polychlorinated biphenyl binding [GO:0097160]; embryo implantation [GO:0007566]; female pregnancy [GO:0007565]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-13 production [GO:0032696]; negative regulation of interleukin-4 production [GO:0032713]; negative regulation of interleukin-5 production [GO:0032714]; negative regulation of T cell proliferation [GO:0042130]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of inflammatory response [GO:0050727]; regulation of mRNA stability [GO:0043488]; response to cytokine [GO:0034097]; response to drug [GO:0042493]; response to fibroblast growth factor [GO:0071774]; response to glucocorticoid [GO:0051384]; response to lipopolysaccharide [GO:0032496]; response to ozone [GO:0010193]; response to silicon dioxide [GO:0034021]; response to xenobiotic stimulus [GO:0009410]; signal transduction [GO:0007165]


uniprotID: Q15853
geneSymbol: USF2
reactome: R-HSA-9018519;
length: 346
go: ENSG00000105698;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)

sequence:

opentargets:
intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; bHLH transcription factor binding [GO:0043425]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; sequence-specific DNA binding [GO:0043565]; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding [GO:0003705]; lactation [GO:0007595]; late viral transcription [GO:0019086]; lipid homeostasis [GO:0055088]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter by glucose [GO:0000432]; regulation of transcription from RNA polymerase II promoter by glucose [GO:0000430]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Additional isoforms seem to exist.; Name=USF2A; IsoId=Q15853-1; Sequence=Displayed; Name=USF2A-delta-H; IsoId=Q15853-2; Sequence=VSP_002165; Name=USF2B; IsoId=Q15853-3; Sequence=VSP_002164; Name=USF2c; IsoId=Q15853-4; Sequence=VSP_047804; Note=Can bind as a homodimer to the E-box of the cathepsin B (CTSB) promoter.; 


uniprotID: Q8TED0
geneSymbol: UTP15
reactome: R-HSA-6790901;R-HSA-6791226;
name: U3 small nucleolar RNA-associated protein 15 homolog
length: 518
go: ENSG00000164338;
snps: rs16870608 rs35313343 rs35898225
sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TED0-1; Sequence=Displayed; Name=2; IsoId=Q8TED0-2; Sequence=VSP_055255; Note=No experimental confirmation available.; Name=3; IsoId=Q8TED0-3; Sequence=VSP_055256; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24219289}. Note=Found predominantly at the fibrillar center. {ECO:0000269|PubMed:24219289}.


uniprotID: A0A1B0GUX0
geneSymbol: ATP6V1FNB
name: Protein ATP6V1FNB (ATP6V1F neighbor gene protein)
length: 176
go: ENSG00000272899;
sequence:
MSRQLNIDALRQNFWKEEYLREKMLRCEWYRKYGSMVKAKQKAKAAARLPLKLPTLHPKAPLSPPPAPKSAPSKVPSPVPEAPFQSEMYPVPPITRALLYEGISHDFQGRYRYLNTRKLDMPETRYLFPITTSFTYGWQLGPPVKQELVSCKMCRIESFFRKNGAFALLDPRDLAL


uniprotID: Q15836
geneSymbol: VAMP3
reactome: R-HSA-1236974;R-HSA-6811440;R-HSA-8856825;R-HSA-8856828;
name: Vesicle-associated membrane protein 3 (VAMP-3) (Cellubrevin) (CEB) (Synaptobrevin-3)
length: 100
go: ENSG00000049245;
sequence:
MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAIGITVLVIFIIIIIVWVVSS

opentargets:
apical plasma membrane [GO:0016324]; cell junction [GO:0030054]; cell surface [GO:0009986]; clathrin-coated vesicle [GO:0030136]; clathrin-coated vesicle membrane [GO:0030665]; cytosol [GO:0005829]; integral component of membrane [GO:0016021]; integral component of synaptic vesicle membrane [GO:0030285]; intracellular [GO:0005622]; intracellular membrane-bounded organelle [GO:0043231]; neuron projection [GO:0043005]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; SNARE complex [GO:0031201]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; syntaxin-1 binding [GO:0017075]; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [GO:0002479]; calcium ion regulated exocytosis [GO:0017156]; cellular response to interferon-gamma [GO:0071346]; exocytosis [GO:0006887]; Golgi to plasma membrane protein transport [GO:0043001]; membrane fusion [GO:0061025]; membrane organization [GO:0061024]; negative regulation of secretion by cell [GO:1903531]; positive regulation of receptor recycling [GO:0001921]; protein-containing complex assembly [GO:0065003]; retrograde transport, endosome to Golgi [GO:0042147]; SNARE complex assembly [GO:0035493]; substrate adhesion-dependent cell spreading [GO:0034446]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.


uniprotID: O75379
geneSymbol: VAMP4
reactome: R-HSA-6811440;R-HSA-8856825;R-HSA-8856828;
name: Vesicle-associated membrane protein 4 (VAMP-4)
length: 141
go: ENSG00000117533;
sequence:
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQVDEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAAILLLVIIILIVMKYRT

opentargets:
cell surface [GO:0009986]; clathrin-coated vesicle membrane [GO:0030665]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of synaptic vesicle membrane [GO:0030285]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; trans-Golgi network membrane [GO:0032588]; transport vesicle [GO:0030133]; Golgi ribbon formation [GO:0090161]; membrane organization [GO:0061024]; microtubule cytoskeleton organization [GO:0000226]; regulation of synaptic vesicle endocytosis [GO:1900242]; SNARE complex assembly [GO:0035493]; synaptic vesicle to endosome fusion [GO:0016189]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75379-1; Sequence=Displayed; Name=2; IsoId=O75379-2; Sequence=VSP_006326; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.


uniprotID: Q52LC2
geneSymbol: ATP6AP1L
name: V-type proton ATPase subunit S1-like protein (Vacuolar proton pump subunit S1-like protein)
length: 224
go: ENSG00000205464;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; proton-transporting V-type ATPase, V1 domain [GO:0033180]; proton-transporting ATP synthase activity, rotational mechanism [GO:0046933]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]


uniprotID: Q86V25
geneSymbol: VASH2
name: Tubulinyl-Tyr carboxypeptidase 2 (EC 3.4.17.17) (Vasohibin-2) (Vasohibin-like protein)
length: 355
go: ENSG00000143494;
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular region [GO:0005576]; actin binding [GO:0003779]; metallocarboxypeptidase activity [GO:0004181]; cell-cell fusion [GO:0140253]; labyrinthine layer blood vessel development [GO:0060716]; positive regulation of angiogenesis [GO:0045766]; positive regulation of endothelial cell proliferation [GO:0001938]; proteolysis [GO:0006508]; syncytium formation by plasma membrane fusion [GO:0000768]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q86V25-1; Sequence=Displayed; Name=2; IsoId=Q86V25-2; Sequence=VSP_013328; Note=No experimental confirmation available.; Name=3; IsoId=Q86V25-3; Sequence=VSP_013329, VSP_013330, VSP_013331; Note=No experimental confirmation available.; Name=4; IsoId=Q86V25-4; Sequence=VSP_013332, VSP_013333; Note=No experimental confirmation available.; Name=5; IsoId=Q86V25-5; Sequence=VSP_013334; Note=No experimental confirmation available.; Name=6; IsoId=Q86V25-6; Sequence=VSP_054104; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19204325}. Secreted {ECO:0000269|PubMed:20736312}. Note=Mainly localizes in the cytoplasm (PubMed:19204325). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:20736312). {ECO:0000269|PubMed:19204325, ECO:0000269|PubMed:20736312}.


uniprotID: Q6EMK4
geneSymbol: VASN
name: Vasorin (Protein slit-like 2)
length: 673
go: ENSG00000168140;
snps: rs3810818
sequence:

opentargets:
cell surface [GO:0009986]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; plasma membrane [GO:0005886]; cadherin binding [GO:0045296]; transforming growth factor beta binding [GO:0050431]; cellular response to hypoxia [GO:0071456]; cellular response to redox state [GO:0071461]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:15247411}; Single-pass type I membrane protein {ECO:0000305|PubMed:15247411}. Secreted {ECO:0000269|PubMed:15247411}.


uniprotID: P36543
geneSymbol: ATP6V1E1
reactome: R-HSA-1222556;R-HSA-77387;R-HSA-917977;R-HSA-983712;
length: 226
go: ENSG00000131100;
snps: rs1060505031 rs1028534806
name:
V-type proton ATPase subunit E 1 (V-ATPase subunit E 1) (V-ATPase 31 kDa subunit) (p31) (Vacuolar proton pump subunit E 1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; cytosol [GO:0005829]; endosome [GO:0005768]; extracellular exosome [GO:0070062]; lysosomal membrane [GO:0005765]; microvillus [GO:0005902]; proton-transporting two-sector ATPase complex [GO:0016469]; proton-transporting two-sector ATPase complex, catalytic domain [GO:0033178]; ATPase binding [GO:0051117]; proton-exporting ATPase activity, phosphorylative mechanism [GO:0008553]; proton-transporting ATPase activity, rotational mechanism [GO:0046961]; ATP hydrolysis coupled proton transport [GO:0015991]; insulin receptor signaling pathway [GO:0008286]; ion transmembrane transport [GO:0034220]; proton transmembrane transport [GO:1902600]; regulation of macroautophagy [GO:0016241]; transferrin transport [GO:0033572]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P36543-1; Sequence=Displayed; Name=2; IsoId=P36543-2; Sequence=VSP_042925; Note=No experimental confirmation available.; Name=3; IsoId=P36543-3; Sequence=VSP_044589; 


uniprotID: P19320
geneSymbol: VCAM1
reactome: R-HSA-198933;R-HSA-216083;R-HSA-6785807;R-HSA-877300;
pdb: 1IJ9;1VCA;1VSC;
name: Vascular cell adhesion protein 1 (V-CAM 1) (VCAM-1) (INCAM-100) (CD antigen CD106)
length: 739
go: ENSG00000162692;
drug: DB05399;DB01136;DB00898;
snps: rs34228330 rs3783611 rs3783612 rs3783613 rs34100871 rs34199378 rs3783615
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
sequence:

opentargets:
alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [GO:0071065]; apical part of cell [GO:0045177]; cell surface [GO:0009986]; early endosome [GO:0005769]; endoplasmic reticulum [GO:0005783]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; filopodium [GO:0030175]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; podosome [GO:0002102]; sarcolemma [GO:0042383]; cell adhesion molecule binding [GO:0050839]; integrin binding [GO:0005178]; primary amine oxidase activity [GO:0008131]; acute inflammatory response [GO:0002526]; aging [GO:0007568]; amine metabolic process [GO:0009308]; B cell differentiation [GO:0030183]; calcium-mediated signaling using intracellular calcium source [GO:0035584]; cardiac neuron differentiation [GO:0060945]; cell adhesion [GO:0007155]; cell chemotaxis [GO:0060326]; cell-matrix adhesion [GO:0007160]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; chronic inflammatory response [GO:0002544]; cytokine-mediated signaling pathway [GO:0019221]; extracellular matrix organization [GO:0030198]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; innervation [GO:0060384]; interferon-gamma-mediated signaling pathway [GO:0060333]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; positive regulation of T cell proliferation [GO:0042102]; regulation of immune response [GO:0050776]; response to ethanol [GO:0045471]; response to hypoxia [GO:0001666]; response to ionizing radiation [GO:0010212]; response to lipopolysaccharide [GO:0032496]; response to nicotine [GO:0035094]; response to nutrient [GO:0007584]; response to zinc ion [GO:0010043]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Long, VCAM-7D; IsoId=P19320-1; Sequence=Displayed; Note=Major isoform.; Name=2; Synonyms=Short, VCAM-6D; IsoId=P19320-2; Sequence=VSP_002580; Name=3; IsoId=P19320-3; Sequence=VSP_044636; Note=No experimental confirmation available.; 


uniprotID: O14598
geneSymbol: VCY; VCY1B
name: Testis-specific basic protein Y 1 (Basic charge, Y-linked 1) (Variably charged protein Y)
length: 125
go: ENSG00000129862;
opentargets: brain development [GO:0007420]
sequence:
MSPKPRASGPPAKAKETGKRKSSSQPSPSGPKKKTTKVAEKGEAVRGGRRGKKGAATKMAAVTAPEAESGPAAPGPSDQPSQELPQHELPPEEPVSEGTQHDPLSQESELEEPLSKGRPSTPLSP


uniprotID: P49765
geneSymbol: VEGFB
reactome: R-HSA-114608;R-HSA-194313;R-HSA-195399;
pdb: 2C7W;2VWE;2XAC;
name: Vascular endothelial growth factor B (VEGF-B) (VEGF-related factor) (VRF)
length: 207
go: ENSG00000173511;
drug: DB08885;
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; chemoattractant activity [GO:0042056]; growth factor activity [GO:0008083]; heparin binding [GO:0008201]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; vascular endothelial growth factor receptor 1 binding [GO:0043183]; vascular endothelial growth factor receptor 2 binding [GO:0043184]; vascular endothelial growth factor receptor 3 binding [GO:0043185]; angiogenesis [GO:0001525]; cardiac muscle contraction [GO:0060048]; coronary vasculature development [GO:0060976]; induction of positive chemotaxis [GO:0050930]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of neuron apoptotic process [GO:0043524]; platelet degranulation [GO:0002576]; positive regulation of angiogenesis [GO:0045766]; positive regulation of cell division [GO:0051781]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of mast cell chemotaxis [GO:0060754]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of vascular wound healing [GO:0035470]; protein O-linked glycosylation [GO:0006493]; response to drug [GO:0042493]; response to hypoxia [GO:0001666]; sprouting angiogenesis [GO:0002040]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; vascular endothelial growth factor signaling pathway [GO:0038084]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms seem to exist.; Name=VEGF-B186; IsoId=P49765-1; Sequence=Displayed; Name=VEGF-B167; IsoId=P49765-2; Sequence=VSP_004639, VSP_004640; 

location:
SUBCELLULAR LOCATION: Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.


uniprotID: P08670
geneSymbol: VIM
reactome: R-HSA-264870;R-HSA-390522;R-HSA-6785807;
name: Vimentin
length: 466
go: ENSG00000026025;
snps: rs121917775 rs1085307141
pdb:
1GK4;1GK6;1GK7;3G1E;3KLT;3S4R;3SSU;3SWK;3TRT;3UF1;4MCY;4MCZ;4MD0;4MD5;4MDI;4MDJ;4YPC;4YV3;5WHF;6ATF;6ATI;6BIR;

sequence:

opentargets:
cell leading edge [GO:0031252]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; intermediate filament [GO:0005882]; neuron projection [GO:0043005]; nuclear matrix [GO:0016363]; peroxisome [GO:0005777]; phagocytic vesicle [GO:0045335]; plasma membrane [GO:0005886]; polysome [GO:0005844]; ribonucleoprotein complex [GO:1990904]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; keratin filament binding [GO:1990254]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; scaffold protein binding [GO:0097110]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of eye lens [GO:0005212]; astrocyte development [GO:0014002]; Bergmann glial cell differentiation [GO:0060020]; cellular response to interferon-gamma [GO:0071346]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to muramyl dipeptide [GO:0071225]; cytokine-mediated signaling pathway [GO:0019221]; intermediate filament organization [GO:0045109]; lens fiber cell development [GO:0070307]; muscle filament sliding [GO:0030049]; negative regulation of neuron projection development [GO:0010977]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of translation [GO:0045727]; regulation of mRNA stability [GO:0043488]; SMAD protein signal transduction [GO:0060395]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21465480, ECO:0000269|PubMed:29496907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:29496907}. Nucleus matrix {ECO:0000250|UniProtKB:P31000}.


uniprotID: Q69YN4
geneSymbol: VIRMA
name: Protein virilizer homolog
length: 1812
go: ENSG00000164944;
snps: rs7814840
sequence:

opentargets:
cytosol [GO:0005829]; nuclear body [GO:0016604]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA N6-methyladenosine methyltransferase complex [GO:0036396]; RNA binding [GO:0003723]; mRNA alternative polyadenylation [GO:0110104]; mRNA methylation [GO:0080009]; mRNA processing [GO:0006397]; multicellular organism development [GO:0007275]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q69YN4-1; Sequence=Displayed; Name=2; IsoId=Q69YN4-2; Sequence=VSP_029019, VSP_029020; Name=3; IsoId=Q69YN4-3; Sequence=VSP_029021; Name=4; IsoId=Q69YN4-4; Sequence=VSP_029017, VSP_029018; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:24100041}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}. Cytoplasm {ECO:0000250|UniProtKB:A2AIV2}. Note=Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus. {ECO:0000250|UniProtKB:A2AIV2}.


uniprotID: Q05940
geneSymbol: SLC18A2
reactome: R-HSA-181429;R-HSA-181430;R-HSA-212676;R-HSA-442660;
length: 514
go: ENSG00000165646;
location: SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane protein.
name:
Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2)

sequence:

opentargets:
clathrin-sculpted monoamine transport vesicle membrane [GO:0070083]; dopaminergic synapse [GO:0098691]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; terminal bouton [GO:0043195]; monoamine transmembrane transporter activity [GO:0008504]; serotonin:sodium symporter activity [GO:0005335]; aminergic neurotransmitter loading into synaptic vesicle [GO:0015842]; chemical synaptic transmission [GO:0007268]; dopamine transport [GO:0015872]; locomotory behavior [GO:0007626]; monoamine transport [GO:0015844]; negative regulation of reactive oxygen species biosynthetic process [GO:1903427]; neurotransmitter loading into synaptic vesicle [GO:0098700]; neurotransmitter secretion [GO:0007269]; neurotransmitter transport [GO:0006836]; post-embryonic development [GO:0009791]; response to amphetamine [GO:0001975]; sequestering of neurotransmitter [GO:0042137]

drug:
DB01472;DB00386;DB00182;DB00865;DB01089;DB01576;DB01363;DB01364;DB06706;DB01577;DB01442;DB00368;DB06714;DB00206;DB04844;

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q05940-1; Sequence=Displayed; Name=2; IsoId=Q05940-2; Sequence=VSP_057151, VSP_057152; Note=No experimental confirmation available.; 


uniprotID: Q9GZP7
geneSymbol: VN1R1
length: 353
go: ENSG00000178201;
snps: rs3746223 rs374900565 rs28649880 rs61744949
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Vomeronasal type-1 receptor 1 (G-protein coupled receptor GPCR24) (hGPCR24) (V1r-like receptor 1) (V3r-related gene protein) (Vomeronasal olfactory receptor chromosome 19 subtype I member 1)

sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; pheromone receptor activity [GO:0016503]; response to pheromone [GO:0019236]


uniprotID: Q7Z7G8
geneSymbol: VPS13B
name: Vacuolar protein sorting-associated protein 13B (Cohen syndrome protein 1)
length: 4022
go: ENSG00000132549;
opentargets: protein transport [GO:0015031]
sequence:

snps:
rs61753721 rs150185067 rs35342235 rs139640224 rs120074149 rs386834104 rs201963516 rs7833870 rs120074153 rs180177370 rs120074155 rs371325199 rs28940272 rs6468694 rs7460625 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=1A; IsoId=Q7Z7G8-1; Sequence=Displayed; Name=2; Synonyms=2A; IsoId=Q7Z7G8-2; Sequence=VSP_009408; Name=3; IsoId=Q7Z7G8-3; Sequence=VSP_009409, VSP_009410; Name=4; IsoId=Q7Z7G8-4; Sequence=VSP_009406, VSP_009407; Name=5; IsoId=Q7Z7G8-5; Sequence=VSP_009404, VSP_009405; Name=6; IsoId=Q7Z7G8-6; Sequence=VSP_039837; 


uniprotID: Q9H267
geneSymbol: VPS33B
name: Vacuolar protein sorting-associated protein 33B (hVPS33B)
length: 617
go: ENSG00000184056;
snps: rs121434385 rs139829189 rs3177428 rs11073964
sequence:

opentargets:
clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule [GO:0031091]; recycling endosome [GO:0055037]; collagen metabolic process [GO:0032963]; endosome organization [GO:0007032]; lysosome localization [GO:0032418]; melanosome localization [GO:0032400]; membrane fusion [GO:0061025]; peptidyl-lysine hydroxylation [GO:0017185]; platelet alpha granule organization [GO:0070889]; protein transport [GO:0015031]; vesicle docking involved in exocytosis [GO:0006904]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H267-1; Sequence=Displayed; Name=2; IsoId=Q9H267-2; Sequence=VSP_056567; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15052268}; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane {ECO:0000269|PubMed:15052268}; Peripheral membrane protein; Cytoplasmic side. Early endosome {ECO:0000269|PubMed:21411634}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21411634}. Recycling endosome {ECO:0000269|PubMed:22753090}. Note=Colocalizes in clusters with VIPAS39 at cytoplasmic organelles (PubMed:19109425). Colocalizes with RAB11A and VIPAS39 on recycling endosomes (PubMed:22753090). Colocalizes with AP-3, clathrin, Rab5 and Rab7b (PubMed:21411634). Colocalizes with M.tuberculosis PtpA in the cytosol of tuberculosis-infected macrophages and associates with phagosomes (PubMed:18474358). {ECO:0000269|PubMed:18474358, ECO:0000269|PubMed:19109425, ECO:0000269|PubMed:21411634, ECO:0000269|PubMed:22753090}.


uniprotID: Q86XT2
geneSymbol: VPS37D
reactome: R-HSA-162588;R-HSA-174490;R-HSA-917729;
length: 251
go: ENSG00000176428;
name:
Vacuolar protein sorting-associated protein 37D (ESCRT-I complex subunit VPS37D) (Williams-Beuren syndrome chromosomal region 24 protein)

sequence:

opentargets:
endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; endosomal transport [GO:0016197]; endosome transport via multivesicular body sorting pathway [GO:0032509]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; protein transport [GO:0015031]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.


uniprotID: Q8N0Z9
geneSymbol: VSIG10
name: V-set and immunoglobulin domain-containing protein 10
length: 540
go: ENSG00000176834;
opentargets: integral component of membrane [GO:0016021]
snps: rs9668527 rs7307331
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N0Z9-1; Sequence=Displayed; Name=2; IsoId=Q8N0Z9-2; Sequence=VSP_034915; 


uniprotID: Q9H8Y1
geneSymbol: VRTN
name: Vertnin
length: 702
go: ENSG00000133980;
snps: rs2232032 rs773509797
sequence:

opentargets:
sequence-specific DNA binding [GO:0043565]; transposase activity [GO:0004803]; transposition, DNA-mediated [GO:0006313]


uniprotID: Q96QK1
geneSymbol: VPS35
reactome: R-HSA-3238698;
pdb: 2R17;5F0J;5F0K;5F0L;5F0M;5F0P;5OSH;5OSI;
length: 796
go: ENSG00000069329;
name:
Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35)

sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; late endosome [GO:0005770]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; mitochondrion-derived vesicle [GO:0099073]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; postsynaptic density [GO:0014069]; presynapse [GO:0098793]; retromer complex [GO:0030904]; retromer, cargo-selective complex [GO:0030906]; tubular endosome [GO:0097422]; D1 dopamine receptor binding [GO:0031748]; protein transporter activity [GO:0008565]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; mitochondrial fragmentation involved in apoptotic process [GO:0043653]; mitochondrion to lysosome transport [GO:0099074]; negative regulation of cell death [GO:0060548]; negative regulation of cellular protein localization [GO:1903828]; negative regulation of gene expression [GO:0010629]; negative regulation of inflammatory response [GO:0050728]; negative regulation of late endosome to lysosome transport [GO:1902823]; negative regulation of lysosomal protein catabolic process [GO:1905166]; negative regulation of neuron death [GO:1901215]; negative regulation of protein homooligomerization [GO:0032463]; neurotransmitter receptor transport, endosome to plasma membrane [GO:0099639]; neurotransmitter receptor transport, endosome to postsynaptic membrane [GO:0098887]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of dopamine biosynthetic process [GO:1903181]; positive regulation of dopamine receptor signaling pathway [GO:0060161]; positive regulation of gene expression [GO:0010628]; positive regulation of locomotion involved in locomotory behavior [GO:0090326]; positive regulation of mitochondrial fission [GO:0090141]; positive regulation of Wnt protein secretion [GO:0061357]; protein destabilization [GO:0031648]; protein localization to organelle [GO:0033365]; regulation of cellular protein metabolic process [GO:0032268]; regulation of dendritic spine maintenance [GO:1902950]; regulation of macroautophagy [GO:0016241]; regulation of mitochondrion organization [GO:0010821]; regulation of presynapse assembly [GO:1905606]; regulation of protein stability [GO:0031647]; regulation of terminal button organization [GO:2000331]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, endosome to plasma membrane [GO:1990126]; synapse assembly [GO:0007416]; transcytosis [GO:0045056]; vesicle-mediated transport in synapse [GO:0099003]; viral process [GO:0016032]; voluntary musculoskeletal movement [GO:0050882]; Wnt signaling pathway [GO:0016055]

snps:
rs193077277 rs183554824 rs188245364 rs192783364 rs770029606 rs184277092 rs34687100 rs188286943 rs749516404 rs192419029 

location:
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Endosome {ECO:0000269|PubMed:15078903}. Early endosome {ECO:0000305}. Late endosome {ECO:0000305}. Note=Localizes to tubular profiles adjacent to endosomes. {ECO:0000269|PubMed:15078903}.


uniprotID: Q9H269
geneSymbol: VPS16
pdb: 4BX9;
name: Vacuolar protein sorting-associated protein 16 homolog (hVPS16)
length: 839
snps: rs367642720 rs35773586
sequence:

opentargets:
autophagosome [GO:0005776]; axon [GO:0030424]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endosome [GO:0005768]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; recycling endosome [GO:0055037]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; autophagosome maturation [GO:0097352]; endosomal transport [GO:0016197]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; regulation of SNARE complex assembly [GO:0035542]; regulation of vacuole fusion, non-autophagic [GO:0032889]; vacuole organization [GO:0007033]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H269-1; Sequence=Displayed; Name=2; IsoId=Q9H269-2; Sequence=VSP_004018; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000269|PubMed:17897319}; Cytoplasmic side {ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000269|PubMed:17897319}; Cytoplasmic side {ECO:0000269|PubMed:17897319}. Early endosome {ECO:0000269|PubMed:18552835}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q920Q4}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:24554770}. Note=Colocalizes with AP-3, clathrin, Rab5 and Rab7b (By similarity). Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes. {ECO:0000250|UniProtKB:Q920Q4, ECO:0000305}.


uniprotID: Q9NZR4
geneSymbol: VSX1
length: 365
go: ENSG00000100987;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
name:
Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1)

sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; neuron development [GO:0048666]; neuron maturation [GO:0042551]; regulation of transcription, DNA-templated [GO:0006355]; response to stimulus [GO:0050896]; retinal bipolar neuron differentiation [GO:0060040]; visual perception [GO:0007601]

snps:
rs74315436 rs6050307 rs140122268 rs74315434 rs74315433 rs74315432 rs771561481 rs749663315 rs148957473 rs576300014 rs74315435 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=L1; IsoId=Q9NZR4-1; Sequence=Displayed; Note=Major form.; Name=2; Synonyms=S1, L3; IsoId=Q9NZR4-2; Sequence=VSP_002302, VSP_002303; Note=Major form.; Name=3; Synonyms=S2; IsoId=Q9NZR4-3; Sequence=VSP_002299, VSP_002302, VSP_002303; Note=Minor form.; Name=4; Synonyms=S3; IsoId=Q9NZR4-4; Sequence=VSP_002300, VSP_002301; Note=Minor form.; Name=5; IsoId=Q9NZR4-5; Sequence=VSP_039144, VSP_039146; Name=6; IsoId=Q9NZR4-6; Sequence=VSP_039140, VSP_039142; Name=7; IsoId=Q9NZR4-7; Sequence=VSP_039141, VSP_039143; Name=8; IsoId=Q9NZR4-8; Sequence=VSP_039145, VSP_039147; 


uniprotID: Q5VTH9
geneSymbol: WDR78
name: WD repeat-containing protein 78
length: 848
go: ENSG00000152763;
snps: rs1886686 rs3008858 rs482082
sequence:

opentargets:
axonemal dynein complex [GO:0005858]; dynein complex [GO:0030286]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; cilium movement [GO:0003341]; hematopoietic progenitor cell differentiation [GO:0002244]; microtubule-based movement [GO:0007018]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5VTH9-1; Sequence=Displayed; Name=2; IsoId=Q5VTH9-2; Sequence=VSP_021816, VSP_021817; Note=No experimental confirmation available.; Name=3; IsoId=Q5VTH9-3; Sequence=VSP_021812, VSP_021815; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q96S55
geneSymbol: WRNIP1
pdb: 3VHS;3VHT;
name: ATPase WRNIP1 (EC 3.6.1.3) (Werner helicase-interacting protein 1)
length: 665
go: ENSG00000124535;
sequence:

opentargets:
membrane [GO:0016020]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; replisome [GO:0030894]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; enzyme activator activity [GO:0008047]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; single-stranded DNA-dependent ATPase activity [GO:0043142]; DNA recombination [GO:0006310]; DNA replication, Okazaki fragment processing [GO:0033567]; DNA strand renaturation [GO:0000733]; DNA synthesis involved in DNA repair [GO:0000731]; DNA-dependent DNA replication [GO:0006261]; innate immune response [GO:0045087]; regulation of DNA repair [GO:0006282]; regulation of DNA-dependent DNA replication initiation [GO:0030174]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:11301316}; IsoId=Q96S55-1; Sequence=Displayed; Name=2 {ECO:0000303|PubMed:14574404}; IsoId=Q96S55-2; Sequence=VSP_051783; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000303|PubMed:14574404}; IsoId=Q96S55-3; Sequence=VSP_051781; Note=No experimental confirmation available. {ECO:0000305}; Name=4 {ECO:0000303|PubMed:14574404}; IsoId=Q96S55-4; Sequence=VSP_051782; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18842586}. Cytoplasm {ECO:0000269|PubMed:29053956}. Note=Colocalizes with WRN in granular structures in the nucleus. {ECO:0000269|PubMed:18842586, ECO:0000269|PubMed:29053956}.


uniprotID: Q86XK7
geneSymbol: VSIG1
name: V-set and immunoglobulin domain-containing protein 1 (Cell surface A33 antigen) (Glycoprotein A34)
length: 387
go: ENSG00000101842;
snps: rs17254305
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; epithelial cell morphogenesis [GO:0003382]; maintenance of gastrointestinal epithelium [GO:0030277]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86XK7-1; Sequence=Displayed; Name=2; IsoId=Q86XK7-2; Sequence=VSP_045475; Note=No experimental confirmation available.; 


uniprotID: Q9UK41
geneSymbol: VPS28
reactome: R-HSA-162588;R-HSA-174490;R-HSA-917729;
name: Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)
length: 221
go: ENSG00000160948;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; plasma membrane [GO:0005886]; protein-containing complex binding [GO:0044877]; ubiquitin binding [GO:0043130]; endosomal transport [GO:0016197]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; negative regulation of protein ubiquitination [GO:0031397]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of ubiquitin-dependent endocytosis [GO:2000397]; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043328]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UK41-1; Sequence=Displayed; Name=2; IsoId=Q9UK41-2; Sequence=VSP_042028; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11916981}. Late endosome membrane {ECO:0000269|PubMed:11916981}; Peripheral membrane protein {ECO:0000269|PubMed:11916981}.


uniprotID: P58304
geneSymbol: VSX2
name: Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)
length: 361
go: ENSG00000119614;
snps: rs35214083 rs121912543 rs121912543 rs755799430 rs121912545
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; multicellular organism development [GO:0007275]; response to stimulus [GO:0050896]; visual perception [GO:0007601]


uniprotID: Q9Y4E1
geneSymbol: WASHC2C
name: WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)
length: 1320
go: ENSG00000172661;
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; WASH complex [GO:0071203]; phosphatidylinositol-3,4,5-trisphosphate binding [GO:0005547]; phosphatidylinositol-3,4-bisphosphate binding [GO:0043325]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; phosphatidylinositol-4-phosphate binding [GO:0070273]; phosphatidylinositol-5-phosphate binding [GO:0010314]; retromer complex binding [GO:1905394]; negative regulation of barbed-end actin filament capping [GO:2000813]; protein transport [GO:0015031]; regulation of substrate adhesion-dependent cell spreading [GO:1900024]; retrograde transport, endosome to Golgi [GO:0042147]; retrograde transport, endosome to plasma membrane [GO:1990126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q9Y4E1-4; Sequence=Displayed; Name=4; IsoId=Q9Y4E1-1; Sequence=VSP_059789; Name=2; IsoId=Q9Y4E1-2; Sequence=VSP_059787, VSP_059789; Note=Gene prediction confirmed by EST data.; Name=3; IsoId=Q9Y4E1-3; Sequence=VSP_059786, VSP_059789; Note=Gene prediction confirmed by EST data.; Name=5; IsoId=Q9Y4E1-5; Sequence=VSP_059788, VSP_059790; Name=6; IsoId=Q9Y4E1-6; Sequence=VSP_059791; 

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:20498093}. Cell membrane. Note=Partially colocalizes with RAB11A, a recycling endosome marker. Associates with lipid raft microdomains on the plasma membrane.


uniprotID: Q5GH72
geneSymbol: XKR7
name: XK-related protein 7
length: 579
go: ENSG00000260903;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q9P2S5
geneSymbol: WRAP73
length: 460
go: ENSG00000116213;
snps: rs2760320 rs16823940
name:
WD repeat-containing protein WRAP73 (WD repeat-containing protein 8) (WD repeat-containing protein antisense to TP73 gene)

sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cell projection organization [GO:0030030]; mitotic spindle assembly [GO:0090307]; positive regulation of non-motile cilium assembly [GO:1902857]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26675238}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:26675238}. Note=Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238). {ECO:0000269|PubMed:26545777, ECO:0000269|PubMed:26675238}.


uniprotID: Q8IUB2
geneSymbol: WFDC3
name: WAP four-disulfide core domain protein 3 (Putative protease inhibitor WAP14)
length: 231
go: ENSG00000124116;
opentargets: extracellular region [GO:0005576]; serine-type endopeptidase inhibitor activity [GO:0004867]
snps: rs6032538 rs6073907
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:


uniprotID: O75351
geneSymbol: VPS4B
reactome: R-HSA-162588;R-HSA-917729;
pdb: 1WR0;1XWI;2CPT;2JQH;2JQK;4U7Y;
length: 444
go: ENSG00000119541;
snps: rs17688948
name:
Vacuolar protein sorting-associated protein 4B (EC 3.6.4.6) (Cell migration-inducing gene 1 protein) (Suppressor of K(+) transport growth defect 1) (Protein SKD1)

sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; Flemming body [GO:0090543]; late endosome membrane [GO:0031902]; nucleus [GO:0005634]; spindle pole [GO:0000922]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; ATPase activity, coupled [GO:0042623]; identical protein binding [GO:0042802]; protein C-terminus binding [GO:0008022]; protein homodimerization activity [GO:0042803]; cholesterol transport [GO:0030301]; endosomal transport [GO:0016197]; endosome to lysosome transport via multivesicular body sorting pathway [GO:0032510]; ESCRT III complex disassembly [GO:1904903]; late endosomal microautophagy [GO:0061738]; macroautophagy [GO:0016236]; midbody abscission [GO:0061952]; mitotic metaphase plate congression [GO:0007080]; multivesicular body assembly [GO:0036258]; negative regulation of cell death [GO:0060548]; negative regulation of exosomal secretion [GO:1903542]; nucleus organization [GO:0006997]; positive regulation of centriole elongation [GO:1903724]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of G2/M transition of mitotic cell cycle [GO:0010971]; positive regulation of viral life cycle [GO:1903902]; positive regulation of viral process [GO:0048524]; positive regulation of viral release from host cell [GO:1902188]; potassium ion transport [GO:0006813]; protein depolymerization [GO:0051261]; protein transport [GO:0015031]; regulation of centrosome duplication [GO:0010824]; regulation of mitotic spindle assembly [GO:1901673]; regulation of viral process [GO:0050792]; response to lipid [GO:0033993]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [GO:0090611]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]; viral release from host cell [GO:0019076]

location:
SUBCELLULAR LOCATION: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells.


uniprotID: Q96JG6
geneSymbol: VPS50
name: Syndetin (Coiled-coil domain-containing protein 132) (EARP/GARPII complex subunit VPS50)
length: 964
go: ENSG00000004766;
location: SUBCELLULAR LOCATION: Recycling endosome {ECO:0000269|PubMed:25799061}.
sequence:

opentargets:
cytosol [GO:0005829]; EARP complex [GO:1990745]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; recycling endosome [GO:0055037]; SNARE binding [GO:0000149]; endocytic recycling [GO:0032456]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96JG6-1; Sequence=Displayed; Name=2; IsoId=Q96JG6-2; Sequence=VSP_028658, VSP_028659; Name=3; IsoId=Q96JG6-3; Sequence=VSP_045572; Note=No experimental confirmation available.; 


uniprotID: Q9NQH7
geneSymbol: XPNPEP3
pdb: 5X49;
name: Xaa-Pro aminopeptidase 3 (X-Pro aminopeptidase 3) (EC 3.4.11.9) (Aminopeptidase P3) (APP3)
length: 507
go: ENSG00000196236;
snps: rs17002243 rs267607179
sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrion [GO:0005739]; aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]; glomerular filtration [GO:0003094]; protein processing [GO:0016485]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=m {ECO:0000303|PubMed:28476889}; IsoId=Q9NQH7-1; Sequence=Displayed; Name=2; Synonyms=c {ECO:0000303|PubMed:28476889}; IsoId=Q9NQH7-2; Sequence=VSP_021296; Name=3; IsoId=Q9NQH7-3; Sequence=VSP_021297, VSP_021298; Note=No experimental confirmation available.; Name=4; IsoId=Q9NQH7-4; Sequence=VSP_040142; Note=No experimental confirmation available.; Name=5; IsoId=Q9NQH7-5; Sequence=VSP_040143, VSP_040144; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Mitochondrion {ECO:0000269|PubMed:20179356, ECO:0000269|PubMed:25609706}. Cytoplasm {ECO:0000269|PubMed:25609706}. Note=Mainly mitochondrial. Translocates to the cytoplasm following TNFRSF1B activation. {ECO:0000269|PubMed:25609706}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:25609706}.


uniprotID: Q9Y6I0
geneSymbol: ERVK-6
length: 156
opentargets: aspartic-type endopeptidase activity [GO:0004190]; nucleic acid binding [GO:0003676]
name:
Endogenous retrovirus group K member 6 Pro protein (HERV-K(C7) Pro protein) (HERV-K(HML-2.HOM) Pro protein) (HERV-K108 Pro protein) (HERV-K_7p22.1 provirus ancestral Pro protein) (EC 3.4.23.50) (Protease) (Proteinase) (PR)

sequence:
WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPAPSYSPTSQKIMTKMGYIPGKGLGKNEDGIKIPVEAKINQEREGIGNPC

isoforms:
ALTERNATIVE PRODUCTS:  Event=Ribosomal frameshifting; Named isoforms=1;  Comment=This protein is synthesized as Gag-Pro and Gag-Pro-Pol polyprotein. These polyproteins are thought, by similarity with type-B retroviruses, to be generated by -1 frameshifts occurring at the Gag-Pro and Pro-Pol genes boundaries.; Name=1; IsoId=Q9Y6I0-1; Sequence=Displayed; 


uniprotID: Q8NEZ2
geneSymbol: VPS37A
reactome: R-HSA-162588;R-HSA-174490;R-HSA-917729;
length: 397
go: ENSG00000155975;
snps: rs17502618 rs17687375 rs211694394
location: SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein. Nucleus.
name:
Vacuolar protein sorting-associated protein 37A (hVps37A) (ESCRT-I complex subunit VPS37A) (Hepatocellular carcinoma-related protein 1)

sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; nucleoplasm [GO:0005654]; endosomal transport [GO:0016197]; endosome transport via multivesicular body sorting pathway [GO:0032509]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; protein transport [GO:0015031]; ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [GO:0043162]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NEZ2-1; Sequence=Displayed; Name=2; Synonyms=beta; IsoId=Q8NEZ2-2; Sequence=VSP_025367; Name=3; IsoId=Q8NEZ2-3; Sequence=VSP_025368, VSP_025369; 


uniprotID: Q86Y07
geneSymbol: VRK2
reactome: R-HSA-2993913;R-HSA-2995383;
pdb: 2V62;5UU1;
name: Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
length: 508
go: ENSG00000028116;
snps: rs34130684 rs35966666 rs1051061 rs36081172
sequence:

opentargets:
cytoplasm [GO:0005737]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; mitochondrial membrane [GO:0031966]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ATP binding [GO:0005524]; protein domain specific binding [GO:0019904]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; cellular response to oxidative stress [GO:0034599]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of interleukin-1-mediated signaling pathway [GO:2000659]; regulation of MAPK cascade [GO:0043408]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=VRK2A; IsoId=Q86Y07-1; Sequence=Displayed; Name=2; Synonyms=VRK2B; IsoId=Q86Y07-2; Sequence=VSP_008537, VSP_008538; Name=3; IsoId=Q86Y07-3; Sequence=VSP_008533; Note=No experimental confirmation available.; Name=4; Synonyms=5; IsoId=Q86Y07-4; Sequence=VSP_008534; Name=5; Synonyms=6; IsoId=Q86Y07-5; Sequence=VSP_008535, VSP_008536; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Nucleus.


uniprotID: Q9UID3
geneSymbol: VPS51
reactome: R-HSA-6811440;
pdb: 4J2C;
length: 782
go: ENSG00000149823;
name:
Vacuolar protein sorting-associated protein 51 homolog (Another new gene 2 protein) (Protein fat-free homolog)

sequence:

opentargets:
cytosol [GO:0005829]; EARP complex [GO:1990745]; GARP complex [GO:0000938]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nucleolus [GO:0005730]; recycling endosome [GO:0055037]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; autophagy [GO:0006914]; endocytic recycling [GO:0032456]; lipid transport [GO:0006869]; lysosomal transport [GO:0007041]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UID3-1; Sequence=Displayed; Name=2; IsoId=Q9UID3-2; Sequence=VSP_014700; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20685960}. Recycling endosome {ECO:0000269|PubMed:25799061}. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061). {ECO:0000269|PubMed:25799061}.


uniprotID: Q9H270
geneSymbol: VPS11
name: Vacuolar protein sorting-associated protein 11 homolog (hVPS11) (RING finger protein 108)
length: 941
snps: rs11558589
sequence:

opentargets:
autophagosome [GO:0005776]; clathrin-coated vesicle [GO:0030136]; early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; HOPS complex [GO:0030897]; late endosome [GO:0005770]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; metal ion binding [GO:0046872]; nucleotide binding [GO:0000166]; protein binding, bridging [GO:0030674]; protein domain specific binding [GO:0019904]; syntaxin binding [GO:0019905]; autophagy [GO:0006914]; endosomal vesicle fusion [GO:0034058]; endosome organization [GO:0007032]; endosome to lysosome transport [GO:0008333]; intracellular protein transport [GO:0006886]; lysosome organization [GO:0007040]; positive regulation of cellular protein catabolic process [GO:1903364]; positive regulation of early endosome to late endosome transport [GO:2000643]; positive regulation of protein targeting to mitochondrion [GO:1903955]; regulation of organelle assembly [GO:1902115]; regulation of protein stability [GO:0031647]; regulation of SNARE complex assembly [GO:0035542]; vesicle docking involved in exocytosis [GO:0006904]

location:
SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:20682791}. Late endosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:21148287}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:11382755, ECO:0000269|PubMed:17897319}; Peripheral membrane protein {ECO:0000269|PubMed:11382755}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:21148287, ECO:0000305}. Cytoplasmic vesicle {ECO:0000305}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000305}.


uniprotID: O14904
geneSymbol: WNT9A
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-3772470;
name: Protein Wnt-9a (Protein Wnt-14)
length: 365
go: ENSG00000143816;
snps: rs8192633
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; cornea development in camera-type eye [GO:0061303]; embryonic forelimb morphogenesis [GO:0035115]; embryonic skeletal joint development [GO:0072498]; embryonic skeletal system morphogenesis [GO:0048704]; iris morphogenesis [GO:0061072]; mitotic cell cycle checkpoint [GO:0007093]; multicellular organism development [GO:0007275]; negative regulation of cell proliferation [GO:0008285]; negative regulation of chondrocyte differentiation [GO:0032331]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; neuron differentiation [GO:0030182]; positive regulation of cell differentiation [GO:0045597]; positive regulation of smoothened signaling pathway [GO:0045880]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted {ECO:0000269|PubMed:26902720}.


uniprotID: Q8N398
geneSymbol: VWA5B2
name: von Willebrand factor A domain-containing protein 5B2
length: 1242
go: ENSG00000145198;
snps: rs902417
sequence:


uniprotID: P56704
geneSymbol: WNT3A
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-3772470;R-HSA-4641262;R-HSA-4641263;R-HSA-5340588;
name: Protein Wnt-3a
length: 352
go: ENSG00000154342;
sequence:

opentargets:
cell surface [GO:0009986]; early endosome membrane [GO:0031901]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; presynapse [GO:0098793]; Wnt-Frizzled-LRP5/6 complex [GO:1990851]; co-receptor binding [GO:0039706]; frizzled binding [GO:0005109]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; transcription coactivator activity [GO:0003713]; axis elongation involved in somitogenesis [GO:0090245]; axon guidance [GO:0007411]; beta-catenin destruction complex disassembly [GO:1904886]; calcium ion transmembrane transport via low voltage-gated calcium channel [GO:0090676]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [GO:0061317]; cell fate commitment [GO:0045165]; cell proliferation [GO:0008283]; cell proliferation in forebrain [GO:0021846]; cell proliferation in midbrain [GO:0033278]; cellular protein localization [GO:0034613]; cellular response to retinoic acid [GO:0071300]; COP9 signalosome assembly [GO:0010387]; dorsal/ventral neural tube patterning [GO:0021904]; extracellular matrix organization [GO:0030198]; heart looping [GO:0001947]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; in utero embryonic development [GO:0001701]; inner ear morphogenesis [GO:0042472]; mammary gland development [GO:0030879]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of axon extension involved in axon guidance [GO:0048843]; negative regulation of dopaminergic neuron differentiation [GO:1904339]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of heart induction by canonical Wnt signaling pathway [GO:0003136]; negative regulation of neurogenesis [GO:0050768]; negative regulation of neuron death [GO:1901215]; negative regulation of neuron projection development [GO:0010977]; neuron differentiation [GO:0030182]; osteoblast differentiation [GO:0001649]; paraxial mesodermal cell fate commitment [GO:0048343]; platelet aggregation [GO:0070527]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [GO:2000081]; positive regulation of cardiac muscle cell differentiation [GO:2000727]; positive regulation of cell proliferation [GO:0008284]; positive regulation of cell-cell adhesion mediated by cadherin [GO:2000049]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of core promoter binding [GO:1904798]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280]; positive regulation of cytokine production [GO:0001819]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of gene expression [GO:0010628]; positive regulation of hepatocyte proliferation [GO:2000347]; positive regulation of mesodermal cell fate specification [GO:0048337]; positive regulation of neural precursor cell proliferation [GO:2000179]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein binding [GO:0032092]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of protein tyrosine kinase activity [GO:0061098]; positive regulation of receptor internalization [GO:0002092]; positive regulation of skeletal muscle tissue development [GO:0048643]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; post-anal tail morphogenesis [GO:0036342]; postsynapse to nucleus signaling pathway [GO:0099527]; presynapse assembly [GO:0099054]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of presynapse assembly [GO:1905606]; regulation of synapse organization [GO:0050807]; secondary palate development [GO:0062009]; skeletal muscle cell differentiation [GO:0035914]; spinal cord association neuron differentiation [GO:0021527]; synaptic vesicle recycling [GO:0036465]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in forebrain neuroblast division [GO:0021874]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P56704-1; Sequence=Displayed; Name=2; IsoId=P56704-2; Sequence=VSP_046558; 

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P27467}. Secreted {ECO:0000269|PubMed:24841207, ECO:0000269|PubMed:26902720}.


uniprotID: Q6UXN9
geneSymbol: WDR82
name: WD repeat-containing protein 82 (Protein TMEM113) (Swd2)
length: 313
go: ENSG00000164091;
sequence:

opentargets:
chromatin [GO:0000785]; histone methyltransferase complex [GO:0035097]; nucleolus [GO:0005730]; PTW/PP1 phosphatase complex [GO:0072357]; Set1C/COMPASS complex [GO:0048188]; chromatin binding [GO:0003682]; histone H3-K4 methylation [GO:0051568]; histone H3-K4 trimethylation [GO:0080182]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16253997, ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20516061}. Note=Associates with chromatin.


uniprotID: Q9H9H4
geneSymbol: VPS37B
reactome: R-HSA-162588;R-HSA-174490;R-HSA-917729;
name: Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)
length: 285
go: ENSG00000139722;
sequence:

opentargets:
cytoplasm [GO:0005737]; endosome [GO:0005768]; endosome membrane [GO:0010008]; ESCRT I complex [GO:0000813]; extracellular exosome [GO:0070062]; late endosome membrane [GO:0031902]; midbody [GO:0030496]; plasma membrane [GO:0005886]; calcium-dependent protein binding [GO:0048306]; endosomal transport [GO:0016197]; endosome transport via multivesicular body sorting pathway [GO:0032509]; macroautophagy [GO:0016236]; multivesicular body assembly [GO:0036258]; positive regulation of viral budding via host ESCRT complex [GO:1903774]; positive regulation of viral release from host cell [GO:1902188]; protein transport [GO:0015031]; viral budding via host ESCRT complex [GO:0039702]; viral life cycle [GO:0019058]

location:
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15218037}; Peripheral membrane protein {ECO:0000269|PubMed:15218037}. Note=Recruited to the endosomal membrane in a VPS4A-dependent fashion.


