# annotation

uniprotID: Q9Y4X1
geneSymbol: UGT2A1
reactome: R-HSA-156588;
name: UDP-glucuronosyltransferase 2A1 (UDPGT 2A1) (EC 2.4.1.17)
length: 527
snps: rs1347046 rs4148301 rs4148304
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]; cellular glucuronidation [GO:0052695]; detection of chemical stimulus [GO:0009593]; sensory perception of smell [GO:0007608]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9Y4X1-1; Sequence=Displayed; Name=2; Synonyms=UGT2A2; IsoId=Q9Y4X1-2; Sequence=VSP_039375; Name=3; Synonyms=UGT2A2 variant 1; IsoId=Q9Y4X1-3; Sequence=VSP_039375, VSP_039376; Name=4; IsoId=Q9Y4X1-4; Sequence=VSP_044733, VSP_039376; Note=No experimental confirmation available.; Name=5; IsoId=Q9Y4X1-5; Sequence=VSP_045577, VSP_039376; Note=No experimental confirmation available.; 


uniprotID: O95258
geneSymbol: SLC25A14
reactome: R-HSA-167826;R-HSA-167827;
length: 325
go: ENSG00000102078;
snps: rs2143598
name:
Brain mitochondrial carrier protein 1 (BMCP-1) (Mitochondrial uncoupling protein 5) (UCP 5) (Solute carrier family 25 member 14)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; mitochondrial inner membrane [GO:0005743]; mitochondrion [GO:0005739]; antiporter activity [GO:0015297]; malate transmembrane transporter activity [GO:0015140]; oxaloacetate transmembrane transporter activity [GO:0015131]; succinate transmembrane transporter activity [GO:0015141]; sulfate transmembrane transporter activity [GO:0015116]; thiosulfate transmembrane transporter activity [GO:0015117]; aerobic respiration [GO:0009060]; malate transmembrane transport [GO:0071423]; mitochondrial transport [GO:0006839]; oxaloacetate transport [GO:0015729]; phosphate ion transmembrane transport [GO:0035435]; proton transmembrane transport [GO:1902600]; succinate transmembrane transport [GO:0071422]; sulfate transport [GO:0008272]; thiosulfate transport [GO:0015709]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=UCP5L; IsoId=O95258-1; Sequence=Displayed; Name=2; Synonyms=UCP5S; IsoId=O95258-2; Sequence=VSP_003272; Name=3; Synonyms=UCP5SI; IsoId=O95258-3; Sequence=VSP_003272, VSP_003273; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q6NUS8
geneSymbol: UGT3A1
reactome: R-HSA-156588;
name: UDP-glucuronosyltransferase 3A1 (UDPGT 3A1) (EC 2.4.1.17)
length: 523
go: ENSG00000145626;
drug: DB01852;DB04216;
snps: rs3756669
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; UDP-N-acetylglucosamine transferase complex [GO:0043541]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NUS8-1; Sequence=Displayed; Name=2; IsoId=Q6NUS8-2; Sequence=VSP_044985, VSP_044986, VSP_044987; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: O75310
geneSymbol: UGT2B11
reactome: R-HSA-156588;
name: UDP-glucuronosyltransferase 2B11 (UDPGT 2B11) (EC 2.4.1.17)
length: 529
go: ENSG00000213759;
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; organelle membrane [GO:0031090]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]; estrogen metabolic process [GO:0008210]; xenobiotic glucuronidation [GO:0052697]; xenobiotic metabolic process [GO:0006805]


uniprotID: Q5JXB2
geneSymbol: UBE2NL
name: Putative ubiquitin-conjugating enzyme E2 N-like (Epididymis tissue protein Li 174)
length: 153
sequence:
MAELPHRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGESKDSPFEGGTFKRELLLAEEYPMAAPKVRFMTKIYHPNVDKLERISLDILKDKWSPALQIRTVLLSIQALLNAPNPDDPLANDVVEQWKTNEAQAIETARAWTRLYAMNSI

opentargets:
extracellular exosome [GO:0070062]; nucleus [GO:0005634]; ubiquitin conjugating enzyme activity [GO:0061631]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]


uniprotID: Q6NVU6
geneSymbol: UFSP1
name: Inactive Ufm1-specific protease 1 (UfSP1)
length: 142
go: ENSG00000176125;
opentargets: UFM1 hydrolase activity [GO:0071567]
snps: rs12666989
sequence:
MGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLHGELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPSELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD


uniprotID: Q9NWZ5
geneSymbol: UCKL1
reactome: R-HSA-73614;
name: Uridine-cytidine kinase-like 1 (EC 2.7.1.48)
length: 548
go: ENSG00000198276;
drug: DB01632;DB04137;DB03419;DB03685;
sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; ATP binding [GO:0005524]; uridine kinase activity [GO:0004849]; CTP salvage [GO:0044211]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9NWZ5-1; Sequence=Displayed; Name=2; IsoId=Q9NWZ5-2; Sequence=VSP_021802; Note=No experimental confirmation available.; Name=3; IsoId=Q9NWZ5-3; Sequence=VSP_025641, VSP_025642; Name=4; IsoId=Q9NWZ5-4; Sequence=VSP_043171; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12199906}. Nucleus {ECO:0000269|PubMed:12199906}. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.


uniprotID: Q9NYU1
geneSymbol: UGGT2
reactome: R-HSA-901032;
length: 1516
go: ENSG00000102595;
snps: rs12863903 rs816142 rs33949518 rs35060832 rs35780499 rs12876018 rs9525072 rs35123499
name:
UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum quality control compartment [GO:0044322]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; protein-containing complex [GO:0032991]; UDP-glucose:glycoprotein glucosyltransferase activity [GO:0003980]; unfolded protein binding [GO:0051082]; endoplasmic reticulum mannose trimming [GO:1904380]; ER-associated misfolded protein catabolic process [GO:0071712]; protein N-linked glycosylation via asparagine [GO:0018279]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NYU1-1; Sequence=Displayed; Name=2; IsoId=Q9NYU1-2; Sequence=VSP_056319, VSP_056320; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000255|PROSITE-ProRule:PRU10138, ECO:0000269|PubMed:12913004}.


uniprotID: Q9H9P5
geneSymbol: UNKL
reactome: R-HSA-983168;
length: 680
go: ENSG00000059145;
name:
Putative E3 ubiquitin-protein ligase UNKL (EC 2.3.2.-) (RING finger protein unkempt-like) (Zinc finger CCCH domain-containing protein 5-like)

sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=4; IsoId=Q9H9P5-4; Sequence=Displayed; Note=Splice site between exons 6 and 7 is non-canonical.; Name=1; IsoId=Q9H9P5-1; Sequence=VSP_039433, VSP_039443; Name=2; IsoId=Q9H9P5-2; Sequence=VSP_039433; Name=3; IsoId=Q9H9P5-3; Sequence=VSP_039432, VSP_039441, VSP_039443; Name=5; IsoId=Q9H9P5-5; Sequence=VSP_039436, VSP_039437; Name=6; IsoId=Q9H9P5-6; Sequence=VSP_039434, VSP_039435, VSP_039438, VSP_039439, VSP_039440, VSP_039442; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 is primarily localized in the cytoplasm but has the ability to shuttle between the nucleus and the cytoplasm.


uniprotID: Q16831
geneSymbol: UPP1
reactome: R-HSA-73614;R-HSA-73621;
pdb: 3EUE;3EUF;3NBQ;
name: Uridine phosphorylase 1 (UPase 1) (UrdPase 1) (EC 2.4.2.3)
length: 310
go: ENSG00000183696;
drug: DB00544;DB05041;
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; uridine phosphorylase activity [GO:0004850]; cellular response to glucose starvation [GO:0042149]; nucleobase-containing compound metabolic process [GO:0006139]; nucleotide catabolic process [GO:0009166]; pyrimidine nucleoside catabolic process [GO:0046135]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]; uridine catabolic process [GO:0006218]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q16831-1; Sequence=Displayed; Name=2; Synonyms=Truncated; IsoId=Q16831-2; Sequence=VSP_001279, VSP_001280; Note=Inactive.; 


uniprotID: O95045
geneSymbol: UPP2
reactome: R-HSA-73614;R-HSA-73621;
pdb: 2XRF;3P0E;3P0F;
name: Uridine phosphorylase 2 (UPase 2) (UrdPase 2) (EC 2.4.2.3)
length: 317
go: ENSG00000007001;
drug: DB00544;DB05041;
snps: rs6710480 rs7561584
sequence:

opentargets:
cytosol [GO:0005829]; type III intermediate filament [GO:0045098]; identical protein binding [GO:0042802]; uridine phosphorylase activity [GO:0004850]; nucleoside metabolic process [GO:0009116]; nucleotide catabolic process [GO:0009166]; pyrimidine nucleoside catabolic process [GO:0046135]; pyrimidine nucleoside salvage [GO:0043097]; UMP salvage [GO:0044206]; uridine metabolic process [GO:0046108]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O95045-1; Sequence=Displayed; Name=2; IsoId=O95045-2; Sequence=VSP_043756; Note=No experimental confirmation available.; 


uniprotID: Q9NU19
geneSymbol: TBC1D22B
pdb: 6D0S;
name: TBC1 domain family member 22B
length: 505
go: ENSG00000065491;
sequence:

opentargets:
intracellular [GO:0005622]; 14-3-3 protein binding [GO:0071889]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]


uniprotID: P0C7X1
geneSymbol: TBC1D3H
name: TBC1 domain family member 3H
length: 549
sequence:

opentargets:
intracellular [GO:0005622]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.


uniprotID: Q9UBB9
geneSymbol: TFIP11
reactome: R-HSA-72163;
name: Tuftelin-interacting protein 11 (Septin and tuftelin-interacting protein 1) (STIP-1)
length: 837
go: ENSG00000100109;
snps: rs6005062
sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; extracellular matrix [GO:0031012]; nuclear chromosome, telomeric region [GO:0000784]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2-type post-mRNA release spliceosomal complex [GO:0071008]; nucleic acid binding [GO:0003676]; biomineral tissue development [GO:0031214]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of DNA ligase activity [GO:1904876]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]; negative regulation of protein binding [GO:0032091]; negative regulation of protein complex assembly [GO:0031333]; protection from non-homologous end joining at telomere [GO:0031848]; RNA processing [GO:0006396]; spliceosomal complex disassembly [GO:0000390]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UBB9-1; Sequence=Displayed; Name=2; IsoId=Q9UBB9-2; Sequence=VSP_003998, VSP_003999; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. {ECO:0000250}.


uniprotID: P48307
geneSymbol: TFPI2
pdb: 1ZR0;
name: Tissue factor pathway inhibitor 2 (TFPI-2) (Placental protein 5) (PP5)
length: 235
go: ENSG00000105825;
snps: rs1804202 rs12669450
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; extracellular matrix structural constituent [GO:0005201]; serine-type endopeptidase inhibitor activity [GO:0004867]; blood coagulation [GO:0007596]; cellular response to fluid shear stress [GO:0071498]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P48307-1; Sequence=Displayed; Name=2; IsoId=P48307-2; Sequence=VSP_056031; Note=No experimental confirmation available.; 


uniprotID: P10599
geneSymbol: TXN
reactome: R-HSA-2559580;R-HSA-3299685;R-HSA-499943;R-HSA-5628897;R-HSA-5676934;R-HSA-844456;
name: Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP)
length: 105
go: ENSG00000136810;
pdb:
1AIU;1AUC;1CQG;1CQH;1ERT;1ERU;1ERV;1ERW;1M7T;1MDI;1MDJ;1MDK;1TRS;1TRU;1TRV;1TRW;1W1C;1W1E;2HSH;2HXK;2IFQ;2IIY;3E3E;3KD0;3M9J;3M9K;3QFA;3QFB;3TRX;4LL1;4LL4;4OO4;4OO5;4POK;4POL;4POM;4PUF;4TRX;5DQY;

sequence:
MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleus [GO:0005634]; peptide disulfide oxidoreductase activity [GO:0015037]; protein disulfide oxidoreductase activity [GO:0015035]; RNA binding [GO:0003723]; activation of protein kinase B activity [GO:0032148]; cell proliferation [GO:0008283]; cell redox homeostasis [GO:0045454]; cell-cell signaling [GO:0007267]; glycerol ether metabolic process [GO:0006662]; negative regulation of hydrogen peroxide-induced cell death [GO:1903206]; negative regulation of protein export from nucleus [GO:0046826]; negative regulation of transcription by RNA polymerase II [GO:0000122]; oxidation-reduction process [GO:0055114]; positive regulation of DNA binding [GO:0043388]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein kinase B signaling [GO:0051897]; regulation of protein import into nucleus, translocation [GO:0033158]; response to radiation [GO:0009314]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P10599-1; Sequence=Displayed; Name=2; IsoId=P10599-2; Sequence=VSP_045607; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Cytoplasm {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:9108029}. Secreted {ECO:0000269|PubMed:1332947}. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947). {ECO:0000269|PubMed:11118054, ECO:0000269|PubMed:1332947, ECO:0000269|PubMed:9108029}.


uniprotID: Q9BZK7
geneSymbol: TBL1XR1
pdb: 4LG9;
length: 514
go: ENSG00000177565;
snps: rs786205859 rs372813783 rs878854401 rs747932785 rs781011308 rs878854402
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
reactome:
R-HSA-1368082;R-HSA-1368108;R-HSA-1989781;R-HSA-2122947;R-HSA-2151201;R-HSA-2426168;R-HSA-2644606;R-HSA-2894862;R-HSA-3214815;R-HSA-381340;R-HSA-400206;R-HSA-400253;

name:
F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)

sequence:

opentargets:
histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptional repressor complex [GO:0017053]; beta-catenin binding [GO:0008013]; histone binding [GO:0042393]; protein N-terminus binding [GO:0047485]; transcription corepressor activity [GO:0003714]; transcription regulatory region DNA binding [GO:0044212]; blastocyst hatching [GO:0001835]; fat pad development [GO:0060613]; histone deacetylation [GO:0016575]; lipid catabolic process [GO:0016042]; multicellular organism growth [GO:0035264]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of triglyceride metabolic process [GO:0090207]; response to dietary excess [GO:0002021]; white fat cell differentiation [GO:0050872]


uniprotID: O15119
geneSymbol: TBX3
pdb: 1H6F;
name: T-box transcription factor TBX3 (T-box protein 3)
length: 743
go: ENSG00000135111;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II activating transcription factor binding [GO:0001102]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II transcription factor binding [GO:0001085]; sequence-specific DNA binding [GO:0043565]; animal organ morphogenesis [GO:0009887]; anterior/posterior axis specification, embryo [GO:0008595]; atrioventricular bundle cell differentiation [GO:0003167]; blood vessel development [GO:0001568]; branching involved in mammary gland duct morphogenesis [GO:0060444]; cardiac muscle cell fate commitment [GO:0060923]; cell aging [GO:0007569]; cellular senescence [GO:0090398]; embryonic digit morphogenesis [GO:0042733]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; female genitalia development [GO:0030540]; follicle-stimulating hormone secretion [GO:0046884]; forelimb morphogenesis [GO:0035136]; heart looping [GO:0001947]; in utero embryonic development [GO:0001701]; limbic system development [GO:0021761]; luteinizing hormone secretion [GO:0032275]; male genitalia development [GO:0030539]; mammary gland development [GO:0030879]; mammary placode formation [GO:0060596]; mesoderm morphogenesis [GO:0048332]; negative regulation of apoptotic process [GO:0043066]; negative regulation of epithelial cell differentiation [GO:0030857]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; outflow tract morphogenesis [GO:0003151]; positive regulation of cell cycle [GO:0045787]; positive regulation of cell proliferation [GO:0008284]; positive regulation of stem cell proliferation [GO:2000648]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of transcription by RNA polymerase II [GO:0006357]; roof of mouth development [GO:0060021]; sinoatrial node cell development [GO:0060931]; skeletal system development [GO:0001501]; specification of animal organ position [GO:0010159]; stem cell population maintenance [GO:0019827]; ventricular septum morphogenesis [GO:0060412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=II; IsoId=O15119-1; Sequence=Displayed; Note=Contains an interrupted T-box domain.; Name=I; IsoId=O15119-2; Sequence=VSP_006384; Name=III; IsoId=O15119-3; Sequence=VSP_006385, VSP_006386; Note=Contains an interrupted T-box domain.; Name=IV; IsoId=O15119-4; Sequence=Not described; Note=May be produced by joining exon 1 to exon 7 thereby eliminating the T-box.; 


uniprotID: P0DPH8
geneSymbol: TUBA3D
name: Tubulin alpha-3D chain (Alpha-tubulin 3D) [Cleaved into: Detyrosinated tubulin alpha-3D chain]
length: 450
go: ENSG00000075886;ENSG00000198033;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; microtubule-based process [GO:0007017]


uniprotID: Q96DN5
geneSymbol: TBC1D31
name: TBC1 domain family member 31 (WD repeat-containing protein 67)
length: 1066
go: ENSG00000156787;
opentargets: centrosome [GO:0005813]
snps: rs16897967 rs16898023 rs34994118
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96DN5-1; Sequence=Displayed; Name=2; IsoId=Q96DN5-2; Sequence=VSP_016184; Note=No experimental confirmation available.; Name=3; IsoId=Q96DN5-3; Sequence=VSP_043414, VSP_016184; Note=No experimental confirmation available.; 


uniprotID: Q7RTU0
geneSymbol: TCF24
name: Transcription factor 24 (TCF-24)
length: 167
go: ENSG00000261787;
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
sequence:
MDRGRPAGSPLSASAEPAPLAAAIRDSRPGRTGPGPAGPGGGSRSGSGRPAAANAARERSRVQTLRHAFLELQRTLPSVPPDTKLSKLDVLLLATTYIAHLTRSLQDDAEAPADAGLGALRGDGYLHPVKKWPMRSRLYIGATGQFLKHSVSGEKTNHDNTPTDSQP


uniprotID: Q9BQ70
geneSymbol: TCF25
name: Transcription factor 25 (TCF-25) (Nuclear localized protein 1)
length: 676
go: ENSG00000141002;
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; heart development [GO:0007507]; negative regulation of transcription by RNA polymerase II [GO:0000122]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16574069, ECO:0000269|PubMed:18068114}. Note=Some staining in the cytosol.


uniprotID: P0C1Z6
geneSymbol: TFPT
reactome: R-HSA-5689603;R-HSA-5696394;
name: TCF3 fusion partner (INO80 complex subunit F) (Protein FB1)
length: 253
go: ENSG00000105619;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18922472}.
sequence:

opentargets:
cytoplasm [GO:0005737]; Ino80 complex [GO:0031011]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; protein deubiquitination [GO:0016579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P0C1Z6-1; Sequence=Displayed; Name=2; IsoId=P0C1Z6-2; Sequence=VSP_058937; 


uniprotID: A0PJX2
geneSymbol: TLDC2
name: TLD domain-containing protein 2 (TBC/LysM-associated domain-containing protein 2)
length: 215
go: ENSG00000101342;
snps: rs3748460
sequence:


uniprotID: Q8IZS6
geneSymbol: TCTE3
reactome: R-HSA-5620924;
length: 198
go: ENSG00000184786;
snps: rs116980543 rs2027063 rs13194101
name:
Tctex1 domain-containing protein 3 (T-complex testis-specific protein 3) (T-complex-associated testis-expressed protein 3) (Tcte-3)

sequence:
MEKRGRGVKSSPIQTPNQTPQQAPVTPRKERRPSMFEKEAYTQILRERLRESIHNVQYVEPPFDDSIADIGKEWKSALAKLKFANSYRMEPLKKFQAHSVETKVQQILTESLKDVKYDDKVFSHLSLELADRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHEAESYVALVLVFALYYE

opentargets:
cytoplasm [GO:0005737]; dynein complex [GO:0030286]; membrane [GO:0016020]; microtubule [GO:0005874]; motor activity [GO:0003774]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasmic granule {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis (By similarity). {ECO:0000250}.


uniprotID: O60907
geneSymbol: TBL1X
pdb: 2XTC;2XTD;2XTE;
length: 577
go: ENSG00000101849;
reactome:
R-HSA-1368082;R-HSA-1368108;R-HSA-1989781;R-HSA-2122947;R-HSA-2151201;R-HSA-2426168;R-HSA-2644606;R-HSA-2894862;R-HSA-3214815;R-HSA-381340;R-HSA-400206;R-HSA-400253;

name:
F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)

sequence:

opentargets:
histone deacetylase complex [GO:0000118]; mitotic spindle [GO:0072686]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcriptional repressor complex [GO:0017053]; beta-catenin binding [GO:0008013]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein C-terminus binding [GO:0008022]; protein domain specific binding [GO:0019904]; transcription corepressor activity [GO:0003714]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; histone deacetylation [GO:0016575]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein stabilization [GO:0050821]; proteolysis [GO:0006508]; regulation of lipid metabolic process [GO:0019216]; regulation of transcription by RNA polymerase II [GO:0006357]; sensory perception of sound [GO:0007605]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O60907-1; Sequence=Displayed; Name=2; IsoId=O60907-2; Sequence=VSP_036905; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalized with MECP2 to the heterochromatin foci. {ECO:0000250|UniProtKB:Q9QXE7}.


uniprotID: P0DPH7
geneSymbol: TUBA3C
length: 450
go: ENSG00000075886;ENSG00000198033;
snps: rs36215077 rs17076703 rs1803092
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
name:
Tubulin alpha-3C chain (Alpha-tubulin 2) (Alpha-tubulin 3C) (Tubulin alpha-2 chain) [Cleaved into: Detyrosinated tubulin alpha-3C chain]

sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; microtubule-based process [GO:0007017]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P0DPH7-1; Sequence=Displayed; Name=2; IsoId=P0DPH7-2; Sequence=VSP_006678; Note=No experimental confirmation available.; 


uniprotID: A0A087WXS9
geneSymbol: TBC1D3I
name: TBC1 domain family member 3I
length: 549
sequence:

opentargets:
intracellular [GO:0005622]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.


uniprotID: Q12870
geneSymbol: TCF15
length: 199
go: ENSG00000125878;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
name:
Transcription factor 15 (TCF-15) (Class A basic helix-loop-helix protein 40) (bHLHa40) (Paraxis) (Protein bHLH-EC2)

sequence:
MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETVRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR

opentargets:
RNA polymerase II transcription factor complex [GO:0090575]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; ear development [GO:0043583]; eating behavior [GO:0042755]; establishment of epithelial cell apical/basal polarity [GO:0045198]; mesenchymal to epithelial transition [GO:0060231]; mesoderm development [GO:0007498]; muscle organ morphogenesis [GO:0048644]; neuromuscular process controlling posture [GO:0050884]; paraxial mesoderm development [GO:0048339]; post-anal tail morphogenesis [GO:0036342]; regulation of extracellular matrix organization [GO:1903053]; regulation of transcription by RNA polymerase II [GO:0006357]; respiratory system process [GO:0003016]; skeletal system morphogenesis [GO:0048705]; skin development [GO:0043588]; somitogenesis [GO:0001756]


uniprotID: Q96BZ9
geneSymbol: TBC1D20
reactome: R-HSA-204005;R-HSA-8854214;
pdb: 4HL4;4HLQ;
name: TBC1 domain family member 20
length: 403
go: ENSG00000125875;
snps: rs36088178
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; integral component of Golgi membrane [GO:0030173]; nuclear membrane [GO:0031965]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; acrosome assembly [GO:0001675]; cargo loading into COPII-coated vesicle [GO:0090110]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi organization [GO:0007030]; lens fiber cell morphogenesis [GO:0070309]; lipid droplet organization [GO:0034389]; positive regulation by host of viral genome replication [GO:0044829]; positive regulation by virus of viral protein levels in host cell [GO:0046726]; positive regulation of ER to Golgi vesicle-mediated transport [GO:1902953]; positive regulation of GTPase activity [GO:0043547]; seminiferous tubule development [GO:0072520]; virion assembly [GO:0019068]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96BZ9-1; Sequence=Displayed; Name=2; IsoId=Q96BZ9-2; Sequence=VSP_008100, VSP_008101, VSP_008102; Note=May be due to intron retention. No experimental confirmation available.; Name=3; IsoId=Q96BZ9-3; Sequence=VSP_031524; Note=No experimental confirmation available.; 


uniprotID: Q9UGU0
geneSymbol: TCF20
length: 1960
go: ENSG00000100207;
snps: rs34030679 rs6002656 rs5758651 rs17002890 rs17002888 rs17002865
location: SUBCELLULAR LOCATION: Nucleus.
name:
Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)

sequence:

opentargets:
nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription coactivator activity [GO:0003713]; transcription regulatory region DNA binding [GO:0044212]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UGU0-1; Sequence=Displayed; Name=2; IsoId=Q9UGU0-2; Sequence=VSP_003984, VSP_003985; 


uniprotID: Q13888
geneSymbol: GTF2H2
pdb: 1Z60;5IVW;5IY6;5IY7;5IY8;5IY9;5O85;5OF4;
length: 395
go: ENSG00000145736;
snps: rs2576895 rs201102513
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27193682}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-167200;R-HSA-167246;R-HSA-427413;R-HSA-5696395;R-HSA-5696400;R-HSA-674695;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6796648;R-HSA-72086;R-HSA-73762;R-HSA-73772;R-HSA-73776;R-HSA-73777;R-HSA-73779;R-HSA-73863;R-HSA-75953;R-HSA-75955;R-HSA-76042;R-HSA-77075;

name:
General transcription factor IIH subunit 2 (Basic transcription factor 2 44 kDa subunit) (BTF2 p44) (General transcription factor IIH polypeptide 2) (TFIIH basal transcription factor complex p44 subunit)

sequence:

opentargets:
core TFIIH complex portion of holo TFIIH complex [GO:0000438]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor TFIID complex [GO:0005669]; transcription factor TFIIH core complex [GO:0000439]; transcription factor TFIIH holo complex [GO:0005675]; DNA-binding transcription factor activity [GO:0003700]; nucleic acid binding [GO:0003676]; protein N-terminus binding [GO:0047485]; translation factor activity, RNA binding [GO:0008135]; zinc ion binding [GO:0008270]; 7-methylguanosine mRNA capping [GO:0006370]; G protein-coupled receptor internalization [GO:0002031]; global genome nucleotide-excision repair [GO:0070911]; nucleotide-excision repair [GO:0006289]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; positive regulation of DNA helicase activity [GO:1905776]; protein phosphorylation [GO:0006468]; regulation of transcription by RNA polymerase II [GO:0006357]; response to UV [GO:0009411]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=1;  Comment=A number of isoforms may be produced. The isoforms may be also produced by incomplete gene duplication.; Name=1; IsoId=Q13888-1; Sequence=Displayed; 


uniprotID: Q86TI0
geneSymbol: TBC1D1
reactome: R-HSA-1445148;
pdb: 3QYE;
name: TBC1 domain family member 1
length: 1168
go: ENSG00000065882;
snps: rs2279027 rs4008480 rs35859249 rs10501 rs7677030 rs13110318
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; membrane organization [GO:0061024]; regulation of protein localization [GO:0032880]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86TI0-1; Sequence=Displayed; Name=2; IsoId=Q86TI0-2; Sequence=VSP_044749, VSP_044750; Note=No experimental confirmation available.; 


uniprotID: Q9UL49
geneSymbol: TCFL5
length: 500
go: ENSG00000101190;
snps: rs17854409 rs34304654
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:9763657}.
name:
Transcription factor-like 5 protein (Cha transcription factor) (HPV-16 E2-binding protein 1) (E2BP-1)

sequence:

opentargets:
male germ cell nucleus [GO:0001673]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell differentiation [GO:0045595]; regulation of cell proliferation [GO:0042127]; regulation of transcription, DNA-templated [GO:0006355]; spermatogenesis [GO:0007283]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=Q9UL49-3; Sequence=Displayed; Name=1; IsoId=Q9UL49-1; Sequence=VSP_030310; Name=2; IsoId=Q9UL49-2; Sequence=VSP_002160; 


uniprotID: Q9H0W7
geneSymbol: THAP2
pdb: 2D8R;
name: THAP domain-containing protein 2
length: 228
go: ENSG00000173451;
snps: rs17110155
sequence:

opentargets:
nucleolus [GO:0005730]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]


uniprotID: Q6ZMP0
geneSymbol: THSD4
reactome: R-HSA-5083635;R-HSA-5173214;
length: 1018
go: ENSG00000187720;
name:
Thrombospondin type-1 domain-containing protein 4 (A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6) (ADAMTS-like protein 6) (ADAMTSL-6)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular exosome [GO:0070062]; microfibril [GO:0001527]; extracellular matrix structural constituent [GO:0005201]; peptidase activity [GO:0008233]; elastic fiber assembly [GO:0048251]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZMP0-1; Sequence=Displayed; Name=2; IsoId=Q6ZMP0-2; Sequence=VSP_030039, VSP_030040; Name=3; IsoId=Q6ZMP0-3; Sequence=VSP_030036, VSP_030037, VSP_030038, VSP_030041; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZMP0-4; Sequence=VSP_054877, VSP_054878; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q3UTY6}.


uniprotID: A6NER0
geneSymbol: TBC1D3F
name: TBC1 domain family member 3F
length: 549
sequence:

opentargets:
intracellular [GO:0005622]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.


uniprotID: Q9BQE3
geneSymbol: TUBA1C
length: 449
go: ENSG00000167553;
drug: DB05147;DB03010;DB01873;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
reactome:
R-HSA-1445148;R-HSA-190840;R-HSA-190861;R-HSA-2132295;R-HSA-2467813;R-HSA-2500257;R-HSA-3371497;R-HSA-380320;R-HSA-389957;R-HSA-389960;R-HSA-389977;R-HSA-437239;R-HSA-5610787;R-HSA-5617833;R-HSA-5620924;R-HSA-5626467;R-HSA-5663220;R-HSA-6807878;R-HSA-6811434;R-HSA-6811436;R-HSA-68877;R-HSA-8852276;R-HSA-8955332;R-HSA-983189;

name:
Tubulin alpha-1C chain (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]

sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; vesicle [GO:0031982]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cell division [GO:0051301]; cytoskeleton-dependent intracellular transport [GO:0030705]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]


uniprotID: Q15813
geneSymbol: TBCE
reactome: R-HSA-389977;
pdb: 4ICU;4ICV;
name: Tubulin-specific chaperone E (Tubulin-folding cofactor E)
length: 527
snps: rs780472451 rs16832611 rs35579976 rs16832619
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; chaperone binding [GO:0051087]; microtubule cytoskeleton organization [GO:0000226]; mitotic spindle organization [GO:0007052]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q15813-1; Sequence=Displayed; Name=2; IsoId=Q15813-2; Sequence=VSP_053870; Note=No experimental confirmation available.; 


uniprotID: Q9UFV1
geneSymbol: TBC1D29
name: Putative TBC1 domain family member 29
length: 150
go: ENSG00000266733;
sequence:
MGHLDKEGLCTQGSSFSWLLRVLNDGISLGLTPCLWDMYLLEGEQMLMLITSIAFKVQRSLYEETNKETWGPATPRALKGTGRARPICESLHSSLQALTASESSRGPSLLQTPPRVPGQQALSRGDKGISVSLSLPSLPSRRGRCGRIIG


uniprotID: Q16762
geneSymbol: TST
reactome: R-HSA-1614517;R-HSA-1614558;
name: Thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese)
length: 297
go: ENSG00000128311;
drug: DB02761;DB09499;
snps: rs35156365 rs1049270
location: SUBCELLULAR LOCATION: Mitochondrion matrix.
sequence:

opentargets:
extracellular space [GO:0005615]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; 5S rRNA binding [GO:0008097]; thiosulfate sulfurtransferase activity [GO:0004792]; cyanate catabolic process [GO:0009440]; epithelial cell differentiation [GO:0030855]; rRNA import into mitochondrion [GO:0035928]; rRNA transport [GO:0051029]; sulfur amino acid catabolic process [GO:0000098]


uniprotID: Q9NS62
geneSymbol: THSD1
reactome: R-HSA-5083635;R-HSA-5173214;
length: 852
go: ENSG00000136114;
snps: rs13313279 rs9536062 rs56013270 rs9536041
name:
Thrombospondin type-1 domain-containing protein 1 (Transmembrane molecule with thrombospondin module)

sequence:

opentargets:
cytosol [GO:0005829]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NS62-1; Sequence=Displayed; Name=2; IsoId=Q9NS62-2; Sequence=VSP_020521; Name=3; IsoId=Q9NS62-3; Sequence=VSP_020522, VSP_020523; 

location:
SUBCELLULAR LOCATION: Isoform 1: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 3: Secreted.


uniprotID: Q6DHY5
geneSymbol: TBC1D3G
name: TBC1 domain family member 3G
length: 549
sequence:

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.


uniprotID: Q8TBP0
geneSymbol: TBC1D16
reactome: R-HSA-8854214;
name: TBC1 domain family member 16
length: 767
go: ENSG00000167291;
snps: rs34845477
sequence:

opentargets:
cytosol [GO:0005829]; early endosome [GO:0005769]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; regulation of receptor recycling [GO:0001919]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8TBP0-1; Sequence=Displayed; Name=2; IsoId=Q8TBP0-2; Sequence=VSP_053995, VSP_053996; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBP0-3; Sequence=VSP_055665, VSP_055668; Note=No experimental confirmation available.; Name=4; IsoId=Q8TBP0-4; Sequence=VSP_055666, VSP_055667; Note=No experimental confirmation available.; 


uniprotID: Q9BVA1
geneSymbol: TUBB2B
name: Tubulin beta-2B chain
length: 445
go: ENSG00000137285;
drug: DB05147;
reactome:
R-HSA-1445148;R-HSA-190840;R-HSA-190861;R-HSA-2132295;R-HSA-2467813;R-HSA-2500257;R-HSA-3371497;R-HSA-380320;R-HSA-389957;R-HSA-389960;R-HSA-389977;R-HSA-437239;R-HSA-5610787;R-HSA-5617833;R-HSA-5620924;R-HSA-5626467;R-HSA-5663220;R-HSA-6807878;R-HSA-6811434;R-HSA-6811436;R-HSA-68877;R-HSA-8852276;R-HSA-8955332;R-HSA-983189;

sequence:

opentargets:
cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; Schaffer collateral - CA1 synapse [GO:0098685]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein heterodimerization activity [GO:0046982]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]; modulation of chemical synaptic transmission [GO:0050804]; neuron migration [GO:0001764]; positive regulation of axon guidance [GO:1902669]

snps:
rs397514569 rs137853194 rs1054331 rs137853195 rs878853284 rs397514568 rs137853196 rs397514567 rs398122369 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23001566, ECO:0000269|PubMed:28013290}.


uniprotID: Q8IUC6
geneSymbol: TICAM1
pdb: 2M1X;2M63;3RC4;4BSX;4C0M;5JEL;
length: 712
go: ENSG00000127666;
snps: rs11466719 rs146550489 rs11466721 rs11466724
reactome:
R-HSA-140534;R-HSA-166166;R-HSA-168164;R-HSA-168927;R-HSA-1810476;R-HSA-2562578;R-HSA-5602566;R-HSA-5602571;R-HSA-9013957;R-HSA-9013973;R-HSA-9014325;R-HSA-936964;R-HSA-937041;R-HSA-937072;R-HSA-975163;

name:
TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)

sequence:

opentargets:
autophagosome [GO:0005776]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; mitochondrion [GO:0005739]; ripoptosome [GO:0097342]; protein kinase binding [GO:0019901]; apoptotic signaling pathway [GO:0097190]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to virus [GO:0051607]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation involved in immune response [GO:0002281]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; necroptotic process [GO:0070266]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; positive regulation of autophagy [GO:0010508]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of chemokine biosynthetic process [GO:0045080]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of myeloid dendritic cell cytokine production [GO:0002735]; positive regulation of natural killer cell activation [GO:0032816]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein binding [GO:0032092]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of protein homodimerization activity [GO:0043496]; response to exogenous dsRNA [GO:0043330]; toll-like receptor 3 signaling pathway [GO:0034138]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:21695056}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80UF7}. Mitochondrion {ECO:0000250|UniProtKB:Q80UF7}. Note=Colocalizes with UBQLN1 in the autophagosome (PubMed:21695056). Colocalizes in the cytosol with DDX1, DDX21 and DHX36. Colocalizes in the mitochondria with DDX1 and poly(I:C) RNA ligand. The multi-helicase-TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA ligand stimulation (By similarity). {ECO:0000250|UniProtKB:Q80UF7, ECO:0000269|PubMed:21695056}.


uniprotID: A6NNZ2
name: Tubulin beta-8 chain-like protein LOC260334
length: 444
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
reactome:
R-HSA-1445148;R-HSA-190840;R-HSA-190861;R-HSA-2132295;R-HSA-2467813;R-HSA-2500257;R-HSA-3371497;R-HSA-380320;R-HSA-437239;R-HSA-5617833;R-HSA-5626467;R-HSA-5663220;R-HSA-6807878;R-HSA-6811434;R-HSA-6811436;R-HSA-68877;R-HSA-8852276;R-HSA-8955332;R-HSA-983189;

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]


uniprotID: P02786
geneSymbol: TFRC
reactome: R-HSA-432722;R-HSA-8856825;R-HSA-8856828;R-HSA-917977;
pdb: 1CX8;1DE4;1SUV;2NSU;3KAS;3S9L;3S9M;3S9N;6D03;6D04;6D05;
length: 760
go: ENSG00000072274;
drug: DB09412;DB05260;
snps: rs863225436 rs3817672 rs41301381 rs41295879 rs41298067
name:
Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; blood microparticle [GO:0072562]; cell surface [GO:0009986]; clathrin-coated pit [GO:0005905]; clathrin-coated vesicle membrane [GO:0030665]; cytoplasmic vesicle [GO:0031410]; early endosome [GO:0005769]; endosome [GO:0005768]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; HFE-transferrin receptor complex [GO:1990712]; integral component of plasma membrane [GO:0005887]; melanosome [GO:0042470]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; double-stranded RNA binding [GO:0003725]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; transferrin receptor activity [GO:0004998]; transferrin transmembrane transporter activity [GO:0033570]; virus receptor activity [GO:0001618]; cellular iron ion homeostasis [GO:0006879]; cellular response to drug [GO:0035690]; cellular response to leukemia inhibitory factor [GO:1990830]; iron ion import [GO:0097286]; membrane organization [GO:0061024]; osteoclast differentiation [GO:0030316]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of bone resorption [GO:0045780]; positive regulation of isotype switching [GO:0045830]; positive regulation of T cell proliferation [GO:0042102]; receptor internalization [GO:0031623]; transferrin transport [GO:0033572]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.; SUBCELLULAR LOCATION: Transferrin receptor protein 1, serum form: Secreted {ECO:0000269|PubMed:17081065}.


uniprotID: Q96SF2
geneSymbol: CCT8L2
name: T-complex protein 1 subunit theta-like 2
length: 557
go: ENSG00000198445;
snps: rs2236639
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40227}.
sequence:

opentargets:
chaperonin-containing T-complex [GO:0005832]; anion channel activity [GO:0005253]; ATP binding [GO:0005524]; calcium-activated potassium channel activity [GO:0015269]


uniprotID: Q9Y458
geneSymbol: TBX22
name: T-box transcription factor TBX22 (T-box protein 22)
length: 520
go: ENSG00000122145;
snps: rs104894944 rs34244923 rs104894946 rs104894943 rs28935177 rs750292974
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; multicellular organism development [GO:0007275]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y458-1; Sequence=Displayed; Name=2; IsoId=Q9Y458-2; Sequence=VSP_040987; 


uniprotID: Q6P9B6
geneSymbol: TLDC1
name: TLD domain-containing protein 1 (TBC/LysM-associated domain-containing protein 1)
length: 456
go: ENSG00000140950;
snps: rs8046813 rs8055536 rs436278 rs431818 rs34244563 rs422145 rs34628943
sequence:

opentargets:
cytoplasm [GO:0005737]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; negative regulation of oxidative stress-induced neuron death [GO:1903204]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24223779}. Cytoplasm {ECO:0000269|PubMed:24223779}.


uniprotID: Q96N35
geneSymbol: LINC00052
name: Putative uncharacterized protein encoded by LINC00052 (Putative transmembrane protein 83)
length: 136
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
MNCDALLHHSAIPEDFLHIFLLLQKISVSLPLSLSQSVCLFYSISLCVSLLLHISLCVSVYVSLSLSSFPCFSLTHTHTHSQLSKDTSVLTFTFCFKQHTHFTLNYTSHAHELSAPSVHPTCVFTFKAAPSPRPAT


uniprotID: A6NDS4
geneSymbol: TBC1D3B
name: TBC1 domain family member 3B
length: 549
go: ENSG00000274808;
sequence:


uniprotID: Q96S53
geneSymbol: TESK2
name: Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)
length: 571
go: ENSG00000070759;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11418599}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein tyrosine kinase activity [GO:0004713]; actin cytoskeleton organization [GO:0030036]; focal adhesion assembly [GO:0048041]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; IsoId=Q96S53-1; Sequence=Displayed; Name=2; IsoId=Q96S53-2; Sequence=VSP_004930; Name=3; IsoId=Q96S53-3; Sequence=VSP_004931; 


uniprotID: Q92664
geneSymbol: GTF3A
reactome: R-HSA-749476;R-HSA-76061;
name: Transcription factor IIIA (TFIIIA)
length: 365
go: ENSG00000122034;
snps: rs7323
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 5S rRNA binding [GO:0008097]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; ribosomal large subunit biogenesis [GO:0042273]; rRNA transcription [GO:0009303]; transcription by RNA polymerase III [GO:0006383]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92664-1; Sequence=Displayed; Name=2; IsoId=Q92664-2; Sequence=VSP_031525, VSP_031526; 


uniprotID: P20366
geneSymbol: TAC1
reactome: R-HSA-380095;R-HSA-416476;
pdb: 2B19;2KS9;2KSA;2KSB;4HOM;
length: 129
go: ENSG00000006128;
location: SUBCELLULAR LOCATION: Secreted.
name:
Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]

sequence:
MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRR

opentargets:
axon [GO:0030424]; cell [GO:0005623]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; neuromedin K receptor binding [GO:0031836]; receptor ligand activity [GO:0048018]; signaling receptor binding [GO:0005102]; substance K receptor binding [GO:0031837]; substance P receptor binding [GO:0031835]; antibacterial humoral response [GO:0019731]; antifungal humoral response [GO:0019732]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; associative learning [GO:0008306]; cell-cell signaling [GO:0007267]; cellular response to nerve growth factor stimulus [GO:1990090]; chemical synaptic transmission [GO:0007268]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; detection of abiotic stimulus [GO:0009582]; detection of temperature stimulus involved in sensory perception of pain [GO:0050965]; G protein-coupled receptor signaling pathway [GO:0007186]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; insemination [GO:0007320]; killing of cells of other organism [GO:0031640]; long-term memory [GO:0007616]; negative regulation of heart rate [GO:0010459]; negative regulation of neuron death [GO:1901215]; negative regulation of systemic arterial blood pressure [GO:0003085]; neuropeptide signaling pathway [GO:0007218]; positive regulation of action potential [GO:0045760]; positive regulation of acute inflammatory response [GO:0002675]; positive regulation of corticosterone secretion [GO:2000854]; positive regulation of cytosolic calcium ion concentration [GO:0007204]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of flagellated sperm motility [GO:1902093]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of neuron death [GO:1901216]; positive regulation of ossification [GO:0045778]; positive regulation of renal sodium excretion [GO:0035815]; positive regulation of saliva secretion [GO:0046878]; positive regulation of sensory perception of pain [GO:1904058]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of synaptic transmission, cholinergic [GO:0032224]; positive regulation of synaptic transmission, GABAergic [GO:0032230]; regulation of blood pressure [GO:0008217]; regulation of sensory perception of pain [GO:0051930]; response to hormone [GO:0009725]; response to lipopolysaccharide [GO:0032496]; response to morphine [GO:0043278]; response to pain [GO:0048265]; response to yeast [GO:0001878]; sensory perception of pain [GO:0019233]; tachykinin receptor signaling pathway [GO:0007217]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=Beta; IsoId=P20366-1; Sequence=Displayed; Name=Alpha; IsoId=P20366-2; Sequence=VSP_006376, VSP_006377; Name=Gamma; IsoId=P20366-3; Sequence=VSP_006375; Name=Delta; IsoId=P20366-4; Sequence=VSP_006375, VSP_006376, VSP_006377; 


uniprotID: Q5SRD1
geneSymbol: TIMM23B
name: Putative mitochondrial import inner membrane translocase subunit Tim23B
length: 257
sequence:

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; P-P-bond-hydrolysis-driven protein transmembrane transporter activity [GO:0015450]; protein transmembrane transporter activity [GO:0008320]; protein import into mitochondrial matrix [GO:0030150]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: P0CG34
geneSymbol: TMSB15A
name: Thymosin beta-15A (NB thymosin beta) (Thymosin-like protein 8)
sequence: MSDKPDLSEVEKFDRSKLKKTNTEEKNTLPSKETIQQEKECVQTS
length: 45
go: ENSG00000158164;ENSG00000158427;ENSG00000269226;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; actin monomer binding [GO:0003785]; actin filament organization [GO:0007015]; regulation of cell migration [GO:0030334]; sequestering of actin monomers [GO:0042989]


uniprotID: Q9C0C2
geneSymbol: TNKS1BP1
reactome: R-HSA-429947;R-HSA-6804115;
name: 182 kDa tankyrase-1-binding protein
length: 1729
go: ENSG00000149115;
snps: rs4939134 rs34203865
sequence:

opentargets:
CCR4-NOT complex [GO:0030014]; cell-cell adherens junction [GO:0005913]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; nuclear heterochromatin [GO:0005720]; nucleus [GO:0005634]; ankyrin repeat binding [GO:0071532]; cadherin binding [GO:0045296]; enzyme binding [GO:0019899]; protein-containing complex binding [GO:0044877]; cellular response to ionizing radiation [GO:0071479]; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; double-strand break repair [GO:0006302]; nuclear-transcribed mRNA poly(A) tail shortening [GO:0000289]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein autophosphorylation [GO:0031954]; telomere maintenance via telomerase [GO:0007004]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9C0C2-1; Sequence=Displayed; Name=2; IsoId=Q9C0C2-2; Sequence=VSP_026000, VSP_026001, VSP_026002; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton. Chromosome. Note=Colocalizes with chromosomes during mitosis, and in the cytoplasm with cortical actin.


uniprotID: P10636
geneSymbol: MAPT
reactome: R-HSA-264870;
length: 758
go: ENSG00000186868;
drug: DB01248;DB01229;
pdb:
1I8H;2MZ7;2ON9;3OVL;4E0M;4E0N;4E0O;4FL5;4GLR;4NP8;4TQE;4Y32;4Y3B;4Y5I;5DMG;5E2V;5E2W;5HF3;5K7N;5MO3;5MP1;5MP5;5N5A;5N5B;5NVB;5O3L;5O3O;5O3T;5V5B;5V5C;5ZV3;6BB4;6CVJ;6CVN;6FBW;6FI5;6GK7;6GK8;6GX5;6H06;

name:
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

sequence:

opentargets:
axolemma [GO:0030673]; axon [GO:0030424]; axon cytoplasm [GO:1904115]; cell body [GO:0044297]; cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; dendrite [GO:0030425]; dendritic spine [GO:0043197]; extracellular region [GO:0005576]; glial cell projection [GO:0097386]; growth cone [GO:0030426]; intracellular [GO:0005622]; main axon [GO:0044304]; membrane raft [GO:0045121]; microtubule [GO:0005874]; microtubule cytoskeleton [GO:0015630]; mitochondrion [GO:0005739]; neurofibrillary tangle [GO:0097418]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nuclear periphery [GO:0034399]; nuclear speck [GO:0016607]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; somatodendritic compartment [GO:0036477]; tubulin complex [GO:0045298]; actin binding [GO:0003779]; apolipoprotein binding [GO:0034185]; AT DNA binding [GO:0003680]; chaperone binding [GO:0051087]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; dynactin binding [GO:0034452]; enzyme binding [GO:0019899]; histone-dependent DNA binding [GO:0099077]; Hsp90 protein binding [GO:0051879]; identical protein binding [GO:0042802]; lipoprotein particle binding [GO:0071813]; microtubule binding [GO:0008017]; microtubule lateral binding [GO:0099609]; phosphatidylinositol binding [GO:0035091]; phosphatidylinositol bisphosphate binding [GO:1902936]; protein binding, bridging [GO:0030674]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; protein phosphatase 2A binding [GO:0051721]; receptor ligand activity [GO:0048018]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; SH3 domain binding [GO:0017124]; single-stranded DNA binding [GO:0003697]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; amyloid fibril formation [GO:1990000]; astrocyte activation [GO:0048143]; axon development [GO:0061564]; axonal transport [GO:0098930]; axonal transport of mitochondrion [GO:0019896]; cell-cell signaling [GO:0007267]; cellular response to brain-derived neurotrophic factor stimulus [GO:1990416]; cellular response to heat [GO:0034605]; cellular response to nerve growth factor stimulus [GO:1990090]; cellular response to reactive oxygen species [GO:0034614]; central nervous system neuron development [GO:0021954]; cytoplasmic microtubule organization [GO:0031122]; generation of neurons [GO:0048699]; internal protein amino acid acetylation [GO:0006475]; intracellular distribution of mitochondria [GO:0048312]; learning or memory [GO:0007611]; memory [GO:0007613]; microglial cell activation [GO:0001774]; microtubule cytoskeleton organization [GO:0000226]; microtubule polymerization [GO:0046785]; negative regulation of establishment of protein localization to mitochondrion [GO:1903748]; negative regulation of gene expression [GO:0010629]; negative regulation of kinase activity [GO:0033673]; negative regulation of mitochondrial fission [GO:0090258]; negative regulation of mitochondrial membrane potential [GO:0010917]; negative regulation of tubulin deacetylation [GO:1904428]; neurofibrillary tangle assembly [GO:1902988]; neuron projection development [GO:0031175]; plus-end-directed organelle transport along microtubule [GO:0072386]; positive regulation of axon extension [GO:0045773]; positive regulation of cellular protein localization [GO:1903829]; positive regulation of diacylglycerol kinase activity [GO:1905689]; positive regulation of microtubule polymerization [GO:0031116]; positive regulation of neuron death [GO:1901216]; positive regulation of protein localization to synapse [GO:1902474]; positive regulation of superoxide anion generation [GO:0032930]; protein complex oligomerization [GO:0051259]; protein homooligomerization [GO:0051260]; regulation of autophagy [GO:0010506]; regulation of calcium-mediated signaling [GO:0050848]; regulation of cellular response to heat [GO:1900034]; regulation of chromosome organization [GO:0033044]; regulation of long-term synaptic depression [GO:1900452]; regulation of microtubule cytoskeleton organization [GO:0070507]; regulation of microtubule polymerization [GO:0031113]; regulation of microtubule polymerization or depolymerization [GO:0031110]; regulation of mitochondrial fission [GO:0090140]; regulation of response to DNA damage stimulus [GO:2001020]; regulation of synaptic plasticity [GO:0048167]; response to lead ion [GO:0010288]; rRNA metabolic process [GO:0016072]; stress granule assembly [GO:0034063]; supramolecular fiber organization [GO:0097435]; synapse assembly [GO:0007416]; synapse organization [GO:0050808]

snps:
rs63750959 rs63750959 rs144611688 rs748728879 rs62063786 rs62063787 rs17651549 rs2258689 rs10445337 rs63750129 rs63750349 rs63750376 rs63750756 rs63750416 rs116733906 rs63751273 rs63751438 rs63751391 rs63751165 rs63750092 rs63750635 rs63750570 rs63750711 rs63750425 rs63751264 rs63750512 rs63750424 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Comment=Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat.; Name=PNS-tau; IsoId=P10636-1; Sequence=Displayed; Name=Fetal-tau; IsoId=P10636-2; Sequence=VSP_003176, VSP_003177, VSP_003179, VSP_003180, VSP_003181; Name=Tau-A; IsoId=P10636-3; Sequence=VSP_003175, VSP_003176, VSP_003177, VSP_003178, VSP_003179, VSP_003180, VSP_003181; Name=Tau-B; IsoId=P10636-4; Sequence=VSP_003177, VSP_003179, VSP_003180, VSP_003181; Name=Tau-C; Synonyms=Tau-3; IsoId=P10636-5; Sequence=VSP_003179, VSP_003180, VSP_003181; Name=Tau-D; IsoId=P10636-6; Sequence=VSP_003176, VSP_003177, VSP_003179, VSP_003180; Name=Tau-E; IsoId=P10636-7; Sequence=VSP_003177, VSP_003179, VSP_003180; Name=Tau-F; Synonyms=Tau-4; IsoId=P10636-8; Sequence=VSP_003179, VSP_003180; Name=Tau-G; IsoId=P10636-9; Sequence=VSP_026780; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10747907}. Cell membrane {ECO:0000269|PubMed:10747907}; Peripheral membrane protein {ECO:0000269|PubMed:10747907}; Cytoplasmic side {ECO:0000269|PubMed:10747907}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10747907}. Cell projection, axon {ECO:0000269|PubMed:10747907}. Cytoplasm {ECO:0000269|PubMed:23666762}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.


uniprotID: A0A087X179
geneSymbol: TBC1D3E
name: TBC1 domain family member 3E
length: 549
sequence:

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.


uniprotID: Q9P2Z0
geneSymbol: THAP10
name: THAP domain-containing protein 10
length: 257
go: ENSG00000129028;
sequence:

opentargets:
DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]


uniprotID: Q96AQ2
geneSymbol: TMEM125
name: Transmembrane protein 125
length: 219
go: ENSG00000179178;
opentargets: integral component of membrane [GO:0016021]
snps: rs35880191
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q6UWW9
geneSymbol: TMEM207
name: Transmembrane protein 207
length: 146
go: ENSG00000198398;
opentargets: integral component of membrane [GO:0016021]
snps: rs35161724
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:
MSRSRLFSVTSAISTIGILCLPLFQLVLSDLPCEEDEMCVNYNDQHPNGWYIWILLLLVLVAALLCGAVVLCLQCWLRRPRIDSHRRTMAVFAVGDLDSIYGTEAAVSPTVGIHLQTQTPDLYPVPAPCFGPLGSPPPYEEIVKTT


uniprotID: Q8N7M0
geneSymbol: TCTEX1D1
reactome: R-HSA-5620924;
name: Tctex1 domain-containing protein 1
length: 179
go: ENSG00000152760;
snps: rs1060575 rs2133173
sequence:
MMMSDNAKGRAAHSWKKRGSISSLSNHEFWRKEIHGRIKDSMSTVSYMEEPSQRDDISRLTVQMENTYQLGPPKHFPVVTVNHILKDVVTSYLQVEEYEPELCRQMTKTISEVIKAQVKDLMIPRYKLIVIVHIGQLNRQSILIGSRCLWDPKSDTFSSYVFRNSSLFALANVYAVYLE

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N7M0-1; Sequence=Displayed; Name=2; IsoId=Q8N7M0-2; Sequence=Not described; 


uniprotID: Q12799
geneSymbol: TCP10
name: T-complex protein 10A homolog
length: 353
opentargets: cytosol [GO:0005829]; nucleus [GO:0005634]
snps: rs17855834
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q12799-1; Sequence=Displayed; Name=2; IsoId=Q12799-2; Sequence=VSP_038517; 


uniprotID: O95988
geneSymbol: TCL1B
length: 128
go: ENSG00000213231;
snps: rs1064017
name:
T-cell leukemia/lymphoma protein 1B (Oncogene TCL-1B) (Oncogene TCL1B) (SYN-1) (Syncytiotrophoblast-specific protein) (TCL1/MTCP1-like protein 1)

sequence:
MASEASVRLGVPPGRLWIQRPGIYEDEEGRTWVTVVVRFNPSRREWARASQGSRYEPSITVHLWQMAVHTRELLSSGQMPFSQLPAVWQLYPGRKYRAADSSFWEIADHGQIDSMEQLVLTYQPERKD

opentargets:
protein-containing complex [GO:0032991]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activator activity [GO:0043539]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein serine/threonine kinase activity [GO:0071902]


uniprotID: O75764
geneSymbol: TCEA3
length: 348
go: ENSG00000204219;
name:
Transcription elongation factor A protein 3 (Transcription elongation factor S-II protein 3) (Transcription elongation factor TFIIS.h)

sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; regulation of transcription, DNA-templated [GO:0006355]; transcription, DNA-templated [GO:0006351]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75764-1; Sequence=Displayed; Name=2; IsoId=O75764-2; Sequence=VSP_056838, VSP_056839; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649, ECO:0000255|PROSITE-ProRule:PRU00651}.


uniprotID: Q99832
geneSymbol: CCT7
reactome: R-HSA-389957;R-HSA-389960;R-HSA-390450;R-HSA-390471;R-HSA-6814122;
length: 543
go: ENSG00000135624;
snps: rs2231427
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P80313}.
name:
T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]

sequence:

opentargets:
cell body [GO:0044297]; chaperonin-containing T-complex [GO:0005832]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; ATP binding [GO:0005524]; identical protein binding [GO:0042802]; unfolded protein binding [GO:0051082]; binding of sperm to zona pellucida [GO:0007339]; positive regulation of establishment of protein localization to telomere [GO:1904851]; positive regulation of protein localization to Cajal body [GO:1904871]; positive regulation of telomerase RNA localization to Cajal body [GO:1904874]; positive regulation of telomere maintenance via telomerase [GO:0032212]; protein folding [GO:0006457]; protein stabilization [GO:0050821]; toxin transport [GO:1901998]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q99832-1; Sequence=Displayed; Name=2; IsoId=Q99832-2; Sequence=VSP_043573, VSP_043574; Note=No experimental confirmation available.; Name=3; IsoId=Q99832-3; Sequence=VSP_043572; Note=No experimental confirmation available. {ECO:0000244|PubMed:22814378}; Name=4; IsoId=Q99832-4; Sequence=VSP_043573; Note=No experimental confirmation available.; 


uniprotID: A6NFQ2
geneSymbol: TCAF2
name: TRPM8 channel-associated factor 2 (TRP channel-associated factor 2)
length: 919
go: ENSG00000170379;
sequence:

opentargets:
cell junction [GO:0030054]; plasma membrane [GO:0005886]; ion channel binding [GO:0044325]; negative regulation of anion channel activity [GO:0010360]; positive regulation of cell migration [GO:0030335]; positive regulation of protein targeting to membrane [GO:0090314]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A6NFQ2-1; Sequence=Displayed; Name=2; IsoId=A6NFQ2-2; Sequence=VSP_031635; Name=3; IsoId=A6NFQ2-3; Sequence=VSP_042050, VSP_042051; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000269|PubMed:25559186}. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269|PubMed:25559186}.


uniprotID: O43151
geneSymbol: TET3
reactome: R-HSA-5221030;
pdb: 4Z3C;
name: Methylcytosine dioxygenase TET3 (EC 1.14.11.n2)
length: 1660
go: ENSG00000187605;
snps: rs57955681
sequence:

opentargets:
chromosome [GO:0005694]; cytoplasm [GO:0005737]; female pronucleus [GO:0001939]; male pronucleus [GO:0001940]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; iron ion binding [GO:0005506]; methylcytosine dioxygenase activity [GO:0070579]; 5-methylcytosine catabolic process [GO:0006211]; DNA demethylation [GO:0080111]; DNA demethylation of male pronucleus [GO:0044727]; histone H3-K4 trimethylation [GO:0080182]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein O-linked glycosylation [GO:0006493]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O43151-1; Sequence=Displayed; Name=2; IsoId=O43151-2; Sequence=VSP_021628; Note=No experimental confirmation available.; Name=3; IsoId=O43151-3; Sequence=VSP_034192; Note=No experimental confirmation available.; Name=4; IsoId=O43151-4; Sequence=VSP_059224; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BG87}. Cytoplasm {ECO:0000250|UniProtKB:Q8BG87}. Chromosome {ECO:0000250|UniProtKB:Q8BG87}. Note=At the zygotic stage, localizes in the male pronucleus, while it localizes to the cytoplasm at other preimplantation stages. Binds to the promoter of target genes, close to the transcription start site. {ECO:0000250|UniProtKB:Q8BG87}.


uniprotID: Q15814
geneSymbol: TBCC
reactome: R-HSA-389977;
pdb: 2L3L;2YUH;
name: Tubulin-specific chaperone C (Tubulin-folding cofactor C) (CFC)
length: 346
go: ENSG00000124659;
snps: rs2234026 rs144361927 rs7742995 rs2234027 rs2234028 rs12175072
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; chaperone binding [GO:0051087]; GTPase activity [GO:0003924]; tubulin binding [GO:0015631]; cell morphogenesis [GO:0000902]; post-chaperonin tubulin folding pathway [GO:0007023]; protein folding [GO:0006457]; tubulin complex assembly [GO:0007021]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12417528}. Note=Detected predominantly in the photoreceptor connecting cilium.


uniprotID: Q8IV04
geneSymbol: TBC1D10C
reactome: R-HSA-6798695;R-HSA-8854214;
name: Carabin (TBC1 domain family member 10C)
length: 446
go: ENSG00000175463;
sequence:

opentargets:
cytosol [GO:0005829]; ficolin-1-rich granule membrane [GO:0101003]; filopodium membrane [GO:0031527]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; activation of GTPase activity [GO:0090630]; intracellular protein transport [GO:0006886]; negative regulation of B cell activation [GO:0050869]; negative regulation of calcineurin-NFAT signaling cascade [GO:0070885]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; neutrophil degranulation [GO:0043312]; retrograde transport, endosome to Golgi [GO:0042147]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IV04-1; Sequence=Displayed; Name=2; IsoId=Q8IV04-2; Sequence=VSP_045992, VSP_045993; Note=No experimental confirmation available.; 


uniprotID: Q9GZM7
geneSymbol: TINAGL1
length: 467
go: ENSG00000142910;
snps: rs17497479
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10799322, ECO:0000269|PubMed:11170462}.
name:
Tubulointerstitial nephritis antigen-like (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2) (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP)

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; cysteine-type peptidase activity [GO:0008234]; extracellular matrix structural constituent [GO:0005201]; laminin binding [GO:0043236]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; cell adhesion [GO:0007155]; endosomal transport [GO:0016197]; immune response [GO:0006955]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9GZM7-1; Sequence=Displayed; Name=2; IsoId=Q9GZM7-2; Sequence=VSP_013094, VSP_013095, VSP_013096, VSP_013097, VSP_013098; Name=3; IsoId=Q9GZM7-3; Sequence=VSP_043712; Note=No experimental confirmation available.; 


uniprotID: P61165
geneSymbol: TMEM258
name: Transmembrane protein 258
sequence: MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV
length: 79
go: ENSG00000134825;
opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; oligosaccharyltransferase I complex [GO:0034998]; protein N-linked glycosylation [GO:0006487]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209}.


uniprotID: Q9Y4G6
geneSymbol: TLN2
name: Talin-2
length: 2542
go: ENSG00000171914;
snps: rs1343670062 rs11634784 rs2280279 rs2280279 rs7182971 rs11633796 rs3816988
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; synapse [GO:0045202]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; structural constituent of cytoskeleton [GO:0005200]; structural molecule activity [GO:0005198]; cell adhesion [GO:0007155]; cell-cell junction assembly [GO:0007043]; cytoskeletal anchoring at plasma membrane [GO:0007016]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27223613}. Cell junction, focal adhesion {ECO:0000269|PubMed:12422219}. Cell junction, synapse {ECO:0000269|PubMed:12422219}. Cell membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:12422219}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12422219}. Note=Focal adhesion plaques and synapses (PubMed:12422219). {ECO:0000269|PubMed:12422219}.


uniprotID: Q9NR00
geneSymbol: TCIM
name: Transcriptional and immune response regulator (Thyroid cancer protein 1) (TC-1)
length: 106
go: ENSG00000176907;
snps: rs6474226
sequence:
MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular [GO:0005622]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; Notch binding [GO:0005112]; apoptotic process [GO:0006915]; cellular response to heat [GO:0034605]; endothelial cell activation involved in immune response [GO:0002264]; negative regulation of apoptotic process [GO:0043066]; negative regulation of Notch signaling pathway [GO:0045746]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of protein kinase A signaling [GO:0010739]; positive regulation of protein kinase C activity [GO:1900020]; regulation of cell cycle G1/S phase transition [GO:1902806]; regulation of DNA-templated transcription in response to stress [GO:0043620]; regulation of hemopoiesis [GO:1903706]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:25985737}. Nucleus, nucleolus {ECO:0000269|PubMed:16424001}. Nucleus speckle {ECO:0000269|PubMed:16424001}. Nucleus {ECO:0000269|PubMed:16424001}. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:17603013}.


uniprotID: Q9BUF5
geneSymbol: TUBB6
name: Tubulin beta-6 chain (Tubulin beta class V)
length: 446
go: ENSG00000176014;
drug: DB05147;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
reactome:
R-HSA-1445148;R-HSA-190840;R-HSA-190861;R-HSA-2132295;R-HSA-2467813;R-HSA-2500257;R-HSA-3371497;R-HSA-380320;R-HSA-389957;R-HSA-389960;R-HSA-389977;R-HSA-437239;R-HSA-5610787;R-HSA-5617833;R-HSA-5620924;R-HSA-5626467;R-HSA-5663220;R-HSA-6807878;R-HSA-6811434;R-HSA-6811436;R-HSA-68877;R-HSA-8852276;R-HSA-8955332;R-HSA-983189;

sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; microtubule [GO:0005874]; nucleus [GO:0005634]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; structural constituent of cytoskeleton [GO:0005200]; microtubule cytoskeleton organization [GO:0000226]; microtubule-based process [GO:0007017]; mitotic cell cycle [GO:0000278]


uniprotID: Q9ULP9
geneSymbol: TBC1D24
reactome: R-HSA-8854214;
name: TBC1 domain family member 24
length: 559
go: ENSG00000162065;
sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; neuromuscular junction [GO:0031594]; plasma membrane [GO:0005886]; terminal bouton [GO:0043195]; GTPase activator activity [GO:0005096]; neuron projection development [GO:0031175]

snps:
rs201257588 rs398122966 rs587777147 rs747821285 rs770820144 rs267607103 rs863223337 rs483352866 rs397514713 rs398122965 rs267607104 rs199700840 rs72768728 rs797044548 rs267607105 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULP9-1; Sequence=Displayed; Name=2; IsoId=Q9ULP9-2; Sequence=VSP_025701; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20727515}; Peripheral membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:20727515}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9VIH7}. Note=Mainly cytoplasmatic with partial expression at the plasma membrane (PubMed:20727515). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). {ECO:0000250|UniProtKB:Q9VIH7, ECO:0000269|PubMed:20727515}.


uniprotID: Q9NZI6
geneSymbol: TFCP2L1
length: 479
go: ENSG00000115112;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10644752}.
name:
Transcription factor CP2-like protein 1 (CP2-related transcriptional repressor 1) (CRTR-1) (Transcription factor LBP-9)

sequence:

opentargets:
fibrillar center [GO:0001650]; membrane [GO:0016020]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714]; cell morphogenesis [GO:0000902]; cytoplasm organization [GO:0007028]; determination of adult lifespan [GO:0008340]; epithelial cell maturation [GO:0002070]; female pregnancy [GO:0007565]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of growth [GO:0045927]; regulation of transcription by RNA polymerase II [GO:0006357]; salivary gland development [GO:0007431]; steroid biosynthetic process [GO:0006694]


uniprotID: Q07654
geneSymbol: TFF3
reactome: R-HSA-9018519;
pdb: 1E9T;1PE3;
name: Trefoil factor 3 (Intestinal trefoil factor) (hITF) (Polypeptide P1.B) (hP1.B)
sequence: MKRVLSCVPEPTVVMAARALCMLGLVLALLSSSSAEEYVGLSANQCAVPAKDRVDCGYPHVTPKECNNRGCCFDSRIPGVPWCFKPLQEAECTF
length: 94
go: ENSG00000160180;
opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; secretory granule [GO:0030141]; maintenance of gastrointestinal epithelium [GO:0030277]; regulation of glucose metabolic process [GO:0010906]

location:
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:8454642}. Cytoplasm {ECO:0000269|PubMed:10824705, ECO:0000269|PubMed:8454642}.


uniprotID: Q9BRJ7
geneSymbol: NUDT16L1
pdb: 3KVH;5ZCJ;6CO1;6D0L;
name: Tudor-interacting repair regulator protein (NUDT16-like protein 1) (Protein syndesmos)
length: 211
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28241136}.
sequence:

opentargets:
nucleus [GO:0005634]; hydrolase activity [GO:0016787]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; negative regulation of double-strand break repair via nonhomologous end joining [GO:2001033]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BRJ7-1; Sequence=Displayed; Name=2; IsoId=Q9BRJ7-2; Sequence=VSP_014276; Note=No experimental confirmation available.; 


uniprotID: Q5VY80
geneSymbol: RAET1L
reactome: R-HSA-163125;
pdb: 4S0U;
name: UL16-binding protein 6 (Retinoic acid early transcript 1L protein)
length: 246
go: ENSG00000155918;
snps: rs1543547 rs912565 rs1555696 rs61730071
sequence:

opentargets:
anchored component of membrane [GO:0031225]; endoplasmic reticulum [GO:0005783]; extracellular region [GO:0005576]; plasma membrane [GO:0005886]; natural killer cell lectin-like receptor binding [GO:0046703]; immune response [GO:0006955]; natural killer cell activation [GO:0030101]; natural killer cell mediated cytotoxicity [GO:0042267]; susceptibility to natural killer cell mediated cytotoxicity [GO:0042271]; T cell mediated cytotoxicity [GO:0001913]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19658097}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:19658097}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9BZM6}. Note=In CMV-infected fibroblasts, detected intracellularly. {ECO:0000269|PubMed:19658097}.


uniprotID: O75385
geneSymbol: ULK1
reactome: R-HSA-1632852;R-HSA-8854214;R-HSA-8876198;R-HSA-8934903;
pdb: 4WNO;4WNP;5CI7;
length: 1050
go: ENSG00000177169;
snps: rs370624303 rs56364352 rs12827141 rs55824543 rs55815560 rs11546871 rs11609348
name:
Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)

sequence:

opentargets:
Atg1/ULK1 kinase complex [GO:1990316]; autophagosome [GO:0005776]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extrinsic component of autophagosome membrane [GO:0097635]; extrinsic component of omegasome membrane [GO:0097629]; extrinsic component of phagophore assembly site membrane [GO:0097632]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; recycling endosome [GO:0055037]; ATP binding [GO:0005524]; GTPase binding [GO:0051020]; identical protein binding [GO:0042802]; kinase activity [GO:0016301]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; Rab GTPase binding [GO:0017137]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of host cells involved in interaction with symbiont [GO:0075044]; axon extension [GO:0048675]; cellular response to nutrient levels [GO:0031669]; macroautophagy [GO:0016236]; negative regulation of protein complex assembly [GO:0031333]; neuron projection development [GO:0031175]; neuron projection regeneration [GO:0031102]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of autophagosome assembly [GO:2000786]; protein autophosphorylation [GO:0046777]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of autophagy [GO:0010506]; regulation of macroautophagy [GO:0016241]; response to starvation [GO:0042594]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Preautophagosomal structure {ECO:0000250}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000250}.


uniprotID: P11172
geneSymbol: UMPS
reactome: R-HSA-500753;
length: 480
go: ENSG00000114491;
drug: DB02890;DB00544;
snps: rs17843776 rs121917890 rs121917892 rs1801019 rs121917891 rs3772809
pdb:
2EAW;2JGY;2P1F;2QCC;2QCD;2QCE;2QCF;2QCG;2QCH;2QCL;2QCM;2QCN;2V30;2WNS;3BGG;3BGJ;3BK0;3BVJ;3DBP;3EWU;3EWW;3EWX;3EWY;3EWZ;3EX1;3EX2;3EX3;3EX4;3EX6;3G3D;3G3M;3L0K;3L0N;3MI2;3MO7;3MW7;4HIB;4HKP;

name:
Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (EC 4.1.1.23) (OMPdecase)]

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; orotate phosphoribosyltransferase activity [GO:0004588]; orotidine-5'-phosphate decarboxylase activity [GO:0004590]; 'de novo' pyrimidine nucleobase biosynthetic process [GO:0006207]; 'de novo' UMP biosynthetic process [GO:0044205]; cellular response to drug [GO:0035690]; female pregnancy [GO:0007565]; lactation [GO:0007595]; pyrimidine nucleoside biosynthetic process [GO:0046134]; UMP biosynthetic process [GO:0006222]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P11172-1; Sequence=Displayed; Name=2; IsoId=P11172-2; Sequence=VSP_009273; Note=No experimental confirmation available.; Name=3; IsoId=P11172-3; Sequence=VSP_047611; Name=4; IsoId=P11172-4; Sequence=VSP_009273, VSP_047612; 


uniprotID: Q6PHR2
geneSymbol: ULK3
reactome: R-HSA-5632684;
pdb: 4WZX;6FDY;6FDZ;
name: Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3)
length: 472
go: ENSG00000140474;
snps: rs34945944 rs12898397
sequence:

opentargets:
ciliary tip [GO:0097542]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; phagophore assembly site [GO:0000407]; ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; cellular senescence [GO:0090398]; negative regulation of smoothened signaling pathway [GO:0045879]; positive regulation of smoothened signaling pathway [GO:0045880]; protein autophosphorylation [GO:0046777]; regulation of autophagy [GO:0010506]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6PHR2-1; Sequence=Displayed; Name=2; IsoId=Q6PHR2-2; Sequence=VSP_038147, VSP_038148; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q6PHR2-3; Sequence=VSP_039925; Note=May be due to competing donor splice site. No experimental confirmation available.; Name=4; IsoId=Q6PHR2-4; Sequence=VSP_057411; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19279323, ECO:0000269|PubMed:19878745}. Note=Localizes to pre-autophagosomal structure during cellular senescence.


uniprotID: Q9H1C4
geneSymbol: UNC93B1
reactome: R-HSA-1679131;R-HSA-5602415;
name: Protein unc-93 homolog B1 (Unc-93B1) (hUNC93B1)
length: 597
go: ENSG00000110057;
snps: rs3175471
sequence:

opentargets:
early phagosome [GO:0032009]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome [GO:0005768]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; lysosome [GO:0005764]; protein transporter activity [GO:0008565]; Toll-like receptor binding [GO:0035325]; adaptive immune response [GO:0002250]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; intracellular protein transport [GO:0006886]; toll-like receptor 3 signaling pathway [GO:0034138]; toll-like receptor 7 signaling pathway [GO:0034154]; toll-like receptor 9 signaling pathway [GO:0034162]; toll-like receptor signaling pathway [GO:0002224]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle, phagosome {ECO:0000250}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity). Colocalizes with LAMP5 in large endosomal intracellular vesicles. {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595}.


uniprotID: Q8N2C9
geneSymbol: UMODL1-AS1
name: Uncharacterized protein UMODL1-AS1 (UMODL1 antisense RNA 1) (UMODL1 antisense gene protein 1)
length: 162
snps: rs220111
sequence:
MAWGLPCHQNTAGANPHLFLGCYSTSSLQGLEYGGQRGDAHGKPGVLHGELEPHDHTSRLERHDLHSQLPTSVQVRHHWWEGALDLAKKRQQQTSINVFTTIKQGSRCDRWMVLGAISLLYNQEEAPDDRPLRARREVRSQHLSWAFPGTAGPGLVCAGDSQ


uniprotID: Q03405
geneSymbol: PLAUR
reactome: R-HSA-162791;R-HSA-6798695;R-HSA-75205;
pdb: 1YWH;2FD6;2I9B;3BT1;3BT2;3U73;3U74;4K24;4QTI;
length: 335
go: ENSG00000011422;
drug: DB00009;DB00029;DB00015;DB00031;DB00013;DB05476;
snps: rs4251813 rs399145 rs4251878 rs2302524 rs4251921 rs16976608 rs4760
name:
Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87)

sequence:

opentargets:
anchored component of membrane [GO:0031225]; cell surface [GO:0009986]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; extracellular region [GO:0005576]; extrinsic component of membrane [GO:0019898]; focal adhesion [GO:0005925]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; invadopodium membrane [GO:0071438]; plasma membrane [GO:0005886]; specific granule membrane [GO:0035579]; enzyme binding [GO:0019899]; protein domain specific binding [GO:0019904]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; urokinase plasminogen activator receptor activity [GO:0030377]; blood coagulation [GO:0007596]; chemotaxis [GO:0006935]; fibrinolysis [GO:0042730]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001268]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; neutrophil degranulation [GO:0043312]; positive regulation of DNA binding [GO:0043388]; positive regulation of epidermal growth factor receptor signaling pathway [GO:0045742]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of release of cytochrome c from mitochondria [GO:0090200]; regulation of proteolysis [GO:0030162]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=uPAR1, GPI-anchored; IsoId=Q03405-1; Sequence=Displayed; Name=2; Synonyms=uPAR2, Secreted; IsoId=Q03405-2; Sequence=VSP_006715; Name=3; IsoId=Q03405-3; Sequence=VSP_046345, VSP_046346; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12376466}. Cell projection, invadopodium membrane {ECO:0000269|PubMed:12376466}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000269|PubMed:12376466}.; SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000250|UniProtKB:P49616}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P49616}.; SUBCELLULAR LOCATION: Isoform 2: Secreted {ECO:0000250|UniProtKB:P49616}.


uniprotID: O00322
geneSymbol: UPK1A
name: Uroplakin-1a (UP1a) (Tetraspanin-21) (Tspan-21) (Uroplakin Ia) (UPIa) (UPKa)
length: 258
go: ENSG00000105668;
snps: rs2267586 rs2285421
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
apical plasma membrane urothelial plaque [GO:0120001]; cell surface [GO:0009986]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; protein homodimerization activity [GO:0042803]; cell surface receptor signaling pathway [GO:0007166]; epithelial cell differentiation [GO:0030855]; protein complex oligomerization [GO:0051259]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00322-1; Sequence=Displayed; Name=2; IsoId=O00322-2; Sequence=VSP_030005; Note=No experimental confirmation available.; 


uniprotID: O75841
geneSymbol: UPK1B
name: Uroplakin-1b (UP1b) (Tetraspanin-20) (Tspan-20) (Uroplakin Ib) (UPIb)
length: 260
go: ENSG00000114638;
snps: rs9840317
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
apical plasma membrane urothelial plaque [GO:0120001]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; structural molecule activity [GO:0005198]; cell surface receptor signaling pathway [GO:0007166]; epithelial cell differentiation [GO:0030855]; response to bacterium [GO:0009617]


uniprotID: Q9BT76
geneSymbol: UPK3B
name: Uroplakin-3b (UP3b) (Uroplakin IIIb) (UPIIIb) (p35)
length: 320
go: ENSG00000243566;
snps: rs1636632 rs1799126
sequence:

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; negative regulation of gene expression [GO:0010629]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BT76-1; Sequence=Displayed; Name=2; IsoId=Q9BT76-2; Sequence=VSP_037327; Name=3; IsoId=Q9BT76-3; Sequence=VSP_037327, VSP_054295; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000269|PubMed:12446744}.


uniprotID: Q6UW78
geneSymbol: UQCC3
name: Ubiquinol-cytochrome-c reductase complex assembly factor 3 (Assembly factor CBP4 homolog)
sequence: MDSLRKMLISVAMLGAGAGVGYALLVIVTPGERRKQEMLKEMPLQDPRSREEAARTQQLLLATLQEAATTQENVAWRKNWMVGGEGGAGGRSP
length: 93
go: ENSG00000204922;
snps: rs606231426
opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; cardiolipin binding [GO:1901612]; phosphatidic acid binding [GO:0070300]; ATP biosynthetic process [GO:0006754]; cristae formation [GO:0042407]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; mitochondrial respiratory chain complex III assembly [GO:0034551]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}; Single-pass membrane protein {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.


uniprotID: Q6BDS2
geneSymbol: UHRF1BP1
length: 1440
go: ENSG00000065060;
opentargets: histone deacetylase binding [GO:0042826]; identical protein binding [GO:0042802]
snps: rs16894945 rs11755393 rs3734265 rs9469913 rs13205210
name:
UHRF1-binding protein 1 (ICBP90-binding protein 1) (Ubiquitin-like containing PHD and RING finger domains 1-binding protein 1)

sequence:


uniprotID: H0YL14
geneSymbol: TMEM250
name: Transmembrane protein 250 (Herpes virus UL25-binding protein)
length: 139
go: ENSG00000238227;
sequence:
MPVMPIPRRVRSFHGPHTTCLHAACGPVRASHLARTKYNNFDVYIKTRWLYGFIRFLLYFSCSLFTAALWGALAALFCLQYLGVRVLLRFQRKLSVLLLLLGRRRVDFRLVNELLVYGIHVTMLLVGGLGWCFMVFVDM

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; septin complex [GO:0031105]; septin filament array [GO:0032160]; septin ring [GO:0005940]; GTPase activity [GO:0003924]; protein-containing complex scaffold activity [GO:0032947]; cilium assembly [GO:0060271]; mitotic cytokinesis [GO:0000281]; positive regulation of cell proliferation [GO:0008284]; positive regulation of viral process [GO:0048524]; septin ring assembly [GO:0000921]; viral process [GO:0016032]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:21667337}. Cytoplasm {ECO:0000269|PubMed:21667337}. Note=Upon HHV-1 infection, accumulates arround the nuclear membrane and translocates into the nucleus.


uniprotID: Q53S58
geneSymbol: TMEM177
name: Transmembrane protein 177
length: 311
go: ENSG00000144120;
opentargets: integral component of mitochondrial inner membrane [GO:0031305]
snps: rs11684353 rs13011768 rs1983406
sequence:

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:29154948}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q9NUR3
geneSymbol: TMEM74B
name: Transmembrane protein 74B
length: 256
go: ENSG00000125895;
opentargets: integral component of membrane [GO:0016021]
snps: rs35393697
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: O14787
geneSymbol: TNPO2
name: Transportin-2 (Karyopherin beta-2b)
length: 897
go: ENSG00000105576;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nucleus [GO:0005634]; nuclear localization sequence binding [GO:0008139]; Ran GTPase binding [GO:0008536]; NLS-bearing protein import into nucleus [GO:0006607]; ribosomal protein import into nucleus [GO:0006610]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14787-1; Sequence=Displayed; Name=2; Synonyms=beta2b; IsoId=O14787-2; Sequence=VSP_009657; Note=No experimental confirmation available.; 


uniprotID: Q9H0C3
geneSymbol: TMEM117
name: Transmembrane protein 117
length: 514
go: ENSG00000139173;
snps: rs1948516
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27391701}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: A0PK05
geneSymbol: TMEM72
name: Transmembrane protein 72 (Kidney-specific secretory protein of 37 kDa)
length: 275
go: ENSG00000187783;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A0PK05-1; Sequence=Displayed; Name=2; IsoId=A0PK05-2; Sequence=VSP_031343; Note=No experimental confirmation available.; 


uniprotID: O43763
geneSymbol: TLX2
pdb: 3A03;
name: T-cell leukemia homeobox protein 2 (Homeobox protein Hox-11L1) (Neural crest homeobox protein)
length: 284
go: ENSG00000115297;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; enteric nervous system development [GO:0048484]; mesoderm formation [GO:0001707]; negative regulation of dendrite morphogenesis [GO:0050774]; positive regulation of transcription by RNA polymerase II [GO:0045944]


uniprotID: O95407
geneSymbol: TNFRSF6B
reactome: R-HSA-5669034;
pdb: 3K51;3MHD;3MI8;4J6G;4KGG;4KGQ;4MSV;5L36;
length: 300
go: ENSG00000243509;
location: SUBCELLULAR LOCATION: Secreted.
name:
Tumor necrosis factor receptor superfamily member 6B (Decoy receptor 3) (DcR3) (Decoy receptor for Fas ligand) (M68)

sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; signaling receptor activity [GO:0038023]; apoptotic process [GO:0006915]; negative regulation of apoptotic process [GO:0043066]; tumor necrosis factor-mediated signaling pathway [GO:0033209]


uniprotID: O00206
geneSymbol: TLR4
pdb: 2Z62;2Z63;2Z65;2Z66;3FXI;3UL7;3UL8;3UL9;3ULA;4G8A;5NAM;5NAO;
name: Toll-like receptor 4 (hToll) (CD antigen CD284)
length: 839
go: ENSG00000136869;
drug: DB02767;DB04933;DB03017;DB08231;DB01183;DB05475;
reactome:
R-HSA-1236974;R-HSA-140534;R-HSA-166016;R-HSA-166058;R-HSA-166166;R-HSA-2562578;R-HSA-5602498;R-HSA-5603041;R-HSA-5686938;R-HSA-9014325;R-HSA-936964;R-HSA-937041;R-HSA-937072;R-HSA-975163;

sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; early endosome [GO:0005769]; endosome membrane [GO:0010008]; external side of plasma membrane [GO:0009897]; integral component of plasma membrane [GO:0005887]; intracellular [GO:0005622]; intrinsic component of plasma membrane [GO:0031226]; lipopolysaccharide receptor complex [GO:0046696]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]; identical protein binding [GO:0042802]; lipopolysaccharide binding [GO:0001530]; lipopolysaccharide receptor activity [GO:0001875]; protein heterodimerization activity [GO:0046982]; signaling receptor activity [GO:0038023]; signaling receptor binding [GO:0005102]; transmembrane signaling receptor activity [GO:0004888]; activation of MAPK activity [GO:0000187]; apoptotic signaling pathway [GO:0097190]; astrocyte development [GO:0014002]; B cell proliferation involved in immune response [GO:0002322]; cellular response to amyloid-beta [GO:1904646]; cellular response to interferon-gamma [GO:0071346]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to lipoteichoic acid [GO:0071223]; cellular response to mechanical stimulus [GO:0071260]; cellular response to oxidised low-density lipoprotein particle stimulus [GO:0140052]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; detection of fungus [GO:0016046]; detection of lipopolysaccharide [GO:0032497]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; I-kappaB phosphorylation [GO:0007252]; immune response [GO:0006955]; inflammatory response [GO:0006954]; innate immune response [GO:0045087]; interferon-gamma production [GO:0032609]; interleukin-1 beta secretion [GO:0050702]; intestinal epithelial structure maintenance [GO:0060729]; lipopolysaccharide-mediated signaling pathway [GO:0031663]; macrophage activation [GO:0042116]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; MyD88-independent toll-like receptor signaling pathway [GO:0002756]; necroptotic process [GO:0070266]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of interferon-gamma production [GO:0032689]; negative regulation of interleukin-17 production [GO:0032700]; negative regulation of interleukin-23 production [GO:0032707]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of MyD88-independent toll-like receptor signaling pathway [GO:0034128]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of tumor necrosis factor production [GO:0032720]; nitric oxide production involved in inflammatory response [GO:0002537]; positive regulation of B cell proliferation [GO:0030890]; positive regulation of cellular response to macrophage colony-stimulating factor stimulus [GO:1903974]; positive regulation of chemokine production [GO:0032722]; positive regulation of cytokine production involved in inflammatory response [GO:1900017]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of inflammatory response [GO:0050729]; positive regulation of interferon-alpha production [GO:0032727]; positive regulation of interferon-beta biosynthetic process [GO:0045359]; positive regulation of interferon-beta production [GO:0032728]; positive regulation of interferon-gamma production [GO:0032729]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-1 production [GO:0032732]; positive regulation of interleukin-10 production [GO:0032733]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; positive regulation of interleukin-12 production [GO:0032735]; positive regulation of interleukin-6 production [GO:0032755]; positive regulation of interleukin-8 biosynthetic process [GO:0045416]; positive regulation of interleukin-8 production [GO:0032757]; positive regulation of JNK cascade [GO:0046330]; positive regulation of macrophage activation [GO:0043032]; positive regulation of macrophage cytokine production [GO:0060907]; positive regulation of MHC class II biosynthetic process [GO:0045348]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of nitric-oxide synthase biosynthetic process [GO:0051770]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway [GO:0070430]; positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway [GO:0070434]; positive regulation of oxidative stress-induced neuron death [GO:1903223]; positive regulation of platelet activation [GO:0010572]; positive regulation of reactive oxygen species biosynthetic process [GO:1903428]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of tumor necrosis factor biosynthetic process [GO:0042535]; positive regulation of tumor necrosis factor production [GO:0032760]; regulation of dendritic cell cytokine production [GO:0002730]; response to lipopolysaccharide [GO:0032496]; T-helper 1 type immune response [GO:0042088]; toll-like receptor 4 signaling pathway [GO:0034142]; toll-like receptor signaling pathway [GO:0002224]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]

snps:
rs16906079 rs5030713 rs5030714 rs4986790 rs2770145 rs2770144 rs5030715 rs5031050 rs11536884 rs4986791 rs4987233 rs5030716 rs5030718 rs5030719 rs5030722 rs5030723 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O00206-1; Sequence=Displayed; Name=2; IsoId=O00206-2; Sequence=VSP_035794; Name=3; IsoId=O00206-3; Sequence=VSP_035793; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11274165, ECO:0000269|PubMed:20037584, ECO:0000269|PubMed:27022195, ECO:0000269|PubMed:9237759}; Single-pass type I membrane protein {ECO:0000269|PubMed:11274165}. Early endosome {ECO:0000269|PubMed:27022195}. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. {ECO:0000269|PubMed:20037584}.


uniprotID: Q8N8V8
geneSymbol: TMEM105
name: Transmembrane protein 105
length: 129
go: ENSG00000185332;
opentargets: integral component of membrane [GO:0016021]
snps: rs9916085
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MLLKVRRASLKPPATPHQGAFRAGNVIGQLIYLLTWSLFTAWLRPPTLLQGPRTSPQGSPPRSPWGDCAEPSCLCEMKIRRRRHEGPAWGQSGFLAGGLHLVPSSLSLAACGVVRMKGLWGRGAGIRGR


uniprotID: O60704
geneSymbol: TPST2
reactome: R-HSA-156584;
pdb: 3AP1;3AP2;3AP3;
name: Protein-tyrosine sulfotransferase 2 (EC 2.8.2.20) (Tyrosylprotein sulfotransferase 2) (TPST-2)
length: 377
go: ENSG00000128294;
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; protein homodimerization activity [GO:0042803]; protein-tyrosine sulfotransferase activity [GO:0008476]; 3'-phosphoadenosine 5'-phosphosulfate metabolic process [GO:0050427]; peptidyl-tyrosine sulfation [GO:0006478]

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25660941}; Single-pass type II membrane protein {ECO:0000269|PubMed:25660941}.


uniprotID: A6NCK2
geneSymbol: TRIM43B
name: Tripartite motif-containing protein 43B
length: 446
go: ENSG00000144010;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: Q9Y3C4
geneSymbol: TPRKB
reactome: R-HSA-6782315;
pdb: 3ENP;
name: EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein)
length: 175
go: ENSG00000144034;
sequence:
MQLTHQLDLFPECRVTLLLFKDVKNAGDLRRKAMEGTIDGSLINPTVIVDPFQILVAANKAVHLYKLGKMKTRTLSTEIIFNLSPNNNISEALKKFGISANDTSILIVYIEEGEKQINQEYLISQVEGHQVSLKNLPEIMNITEVKKIYKLSSQEESIGTLLDAIICRMSTKDVL

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; EKC/KEOPS complex [GO:0000408]; nucleus [GO:0005634]; protein kinase binding [GO:0019901]; tRNA threonylcarbamoyladenosine modification [GO:0002949]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y3C4-1; Sequence=Displayed; Name=2; Synonyms=S1; IsoId=Q9Y3C4-2; Sequence=VSP_023414; Name=3; Synonyms=L1; IsoId=Q9Y3C4-3; Sequence=VSP_023415; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12659830, ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:12659830, ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:28805828}.


uniprotID: P07204
geneSymbol: THBD
reactome: R-HSA-140875;R-HSA-202733;
pdb: 1ADX;1DQB;1DX5;1EGT;1FGD;1FGE;1HLT;1TMR;1ZAQ;2ADX;3GIS;5TO3;
name: Thrombomodulin (TM) (Fetomodulin) (CD antigen CD141)
length: 575
go: ENSG00000178726;
drug: DB00055;DB01050;
snps: rs1800576 rs121918667 rs1800577 rs36110902 rs758686992 rs1042579 rs41348347 rs1800578 rs1800579
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
sequence:

opentargets:
apicolateral plasma membrane [GO:0016327]; cell surface [GO:0009986]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; vacuolar membrane [GO:0005774]; calcium ion binding [GO:0005509]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; blood coagulation [GO:0007596]; female pregnancy [GO:0007565]; negative regulation of blood coagulation [GO:0030195]; negative regulation of fibrinolysis [GO:0051918]; negative regulation of platelet activation [GO:0010544]; response to cAMP [GO:0051591]; response to lipopolysaccharide [GO:0032496]; response to X-ray [GO:0010165]


uniprotID: P0DMS9
geneSymbol: TMIGD3
name: Transmembrane domain-containing protein TMIGD3
length: 266
go: ENSG00000121933;
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; activation of adenylate cyclase activity [GO:0007190]; inflammatory response [GO:0006954]; negative regulation of cell migration [GO:0030336]; negative regulation of cell proliferation [GO:0008285]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; regulation of heart contraction [GO:0008016]; response to wounding [GO:0009611]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; Synonyms=TMIGD3 i3 {ECO:0000303|PubMed:27886186}, A3AR i3 {ECO:0000303|PubMed:27886186}; IsoId=P0DMS9-1; Sequence=Displayed; Name=1; Synonyms=TMIGD3 i1 {ECO:0000303|PubMed:27886186}, A3AR i1 {ECO:0000303|PubMed:27886186}; IsoId=P0DMS9-2; Sequence=VSP_057521; Note=The first exon of TMIGD3 isoform 1 (i1) is shared with the first exon of ADORA3 isoform 2 (A3AR i2, commonly known as A3AR), resulting in a fusion protein. {ECO:0000303|PubMed:27886186}; Name=2; Synonyms=A3AR i2 {ECO:0000303|PubMed:27886186}, A3AR {ECO:0000303|PubMed:27886186}; IsoId=P0DMS8-1; Sequence=External; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:27886186}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q5VZI3
geneSymbol: TMEM268
name: Transmembrane protein 268
length: 342
go: ENSG00000157693;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5VZI3-1; Sequence=Displayed; Name=2; IsoId=Q5VZI3-2; Sequence=VSP_023426; Note=No experimental confirmation available.; Name=3; IsoId=Q5VZI3-3; Sequence=VSP_023427; 


uniprotID: Q9GZU3
geneSymbol: TMEM39B
name: Transmembrane protein 39B
length: 492
go: ENSG00000121775;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9GZU3-1; Sequence=Displayed; Name=2; IsoId=Q9GZU3-2; Sequence=VSP_056125, VSP_056126; Note=No experimental confirmation available.; Name=3; IsoId=Q9GZU3-3; Sequence=VSP_056124, VSP_056127, VSP_056128; Note=No experimental confirmation available.; Name=4; IsoId=Q9GZU3-4; Sequence=VSP_056123; Note=No experimental confirmation available.; 


uniprotID: Q8WY98
geneSymbol: TMEM234
name: Transmembrane protein 234
length: 164
go: ENSG00000160055;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MAASLGQVLALVLVAALWGGTQPLLKRASAGLQRVHEPTWAQQLLQEMKTLFLNTEYLMPFLLNQCGSLLYYLTLASTDLTLAVPICNSLAIIFTLIVGKALGEDIGGKRAVAGMVLTVIGISLCITSSVPWTAELQLHGKGQLQTLSQKCKREASGTQSERFG

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8WY98-1; Sequence=Displayed; Name=2; IsoId=Q8WY98-2; Sequence=VSP_028107; Name=3; IsoId=Q8WY98-3; Sequence=VSP_028108, VSP_028109; Name=4; IsoId=Q8WY98-4; Sequence=VSP_028105, VSP_028106; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: P17752
geneSymbol: TPH1
reactome: R-HSA-209931;
pdb: 1IN9;1MLW;3HF6;3HF8;3HFB;5J6D;5L01;5TPG;
name: Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1)
length: 444
go: ENSG00000129167;
drug: DB00150;DB05199;DB00360;DB12095;
sequence:

opentargets:
cytosol [GO:0005829]; neuron projection [GO:0043005]; iron ion binding [GO:0005506]; tryptophan 5-monooxygenase activity [GO:0004510]; aromatic amino acid family metabolic process [GO:0009072]; bone remodeling [GO:0046849]; circadian rhythm [GO:0007623]; mammary gland alveolus development [GO:0060749]; negative regulation of ossification [GO:0030279]; positive regulation of fat cell differentiation [GO:0045600]; response to immobilization stress [GO:0035902]; serotonin biosynthetic process [GO:0042427]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P17752-1; Sequence=Displayed; Name=2; IsoId=P17752-2; Sequence=VSP_000546; 


uniprotID: Q92547
geneSymbol: TOPBP1
reactome: R-HSA-5685938;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;
pdb: 1WF6;2XNH;2XNK;3AL2;3AL3;3JVE;3OLC;3PD7;3UEN;3UEO;
length: 1522
go: ENSG00000163781;
snps: rs17301766 rs10935070 rs10935070
name:
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; chromosome [GO:0005694]; condensed nuclear chromosome [GO:0000794]; cytoplasm [GO:0005737]; male germ cell nucleus [GO:0001673]; microtubule organizing center [GO:0005815]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; spindle pole [GO:0000922]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; protein C-terminus binding [GO:0008022]; cellular response to DNA damage stimulus [GO:0006974]; DNA metabolic process [GO:0006259]; DNA repair [GO:0006281]; mitotic DNA replication checkpoint [GO:0033314]; response to ionizing radiation [GO:0010212]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Detected on unpaired autosomes in meiotic prophase cells. Detected on X and Y chromosomes during later stages of prophase. Colocalizes with ATR and H2AFX at unsynapsed chromosome cores during prophase (By similarity). Has a uniform nuclear distribution during G phase. Colocalizes with BRCA1 at stalled replication forks during S phase. In mitotic cells it colocalizes with BRCA1 at spindle poles and centrosomes during metaphase and anaphase. Detected in discrete foci together with PML and numerous DNA repair enzymes after DNA damage by alkylating agents, UV or gamma irradiation. Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250}.


uniprotID: Q9Y2W1
geneSymbol: THRAP3
reactome: R-HSA-1989781;R-HSA-381340;
length: 955
go: ENSG00000054118;
snps: rs6425977
name:
Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)

sequence:

opentargets:
extracellular exosome [GO:0070062]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; nuclear receptor transcription coactivator activity [GO:0030374]; phosphoprotein binding [GO:0051219]; RNA binding [GO:0003723]; RNA polymerase II distal enhancer sequence-specific DNA binding [GO:0000980]; signaling receptor activity [GO:0038023]; thyroid hormone receptor binding [GO:0046966]; transcription coactivator activity [GO:0003713]; transcription coregulator activity [GO:0003712]; vitamin D receptor binding [GO:0042809]; androgen receptor signaling pathway [GO:0030521]; circadian rhythm [GO:0007623]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of alternative mRNA splicing, via spliceosome [GO:0000381]; RNA splicing [GO:0008380]; transcription initiation from RNA polymerase II promoter [GO:0006367]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20123736, ECO:0000269|PubMed:23525231}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24100041}. Nucleus speckle {ECO:0000269|PubMed:24100041}.


uniprotID: Q13595
geneSymbol: TRA2A
name: Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A)
length: 282
go: ENSG00000164548;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9546399}.
sequence:

opentargets:
intracellular membrane-bounded organelle [GO:0043231]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA binding [GO:0003723]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=Long; IsoId=Q13595-1; Sequence=Displayed; Name=Short; IsoId=Q13595-2; Sequence=VSP_005893, VSP_005894, VSP_005895; Name=3; IsoId=Q13595-3; Sequence=VSP_005893; Note=No experimental confirmation available.; Name=4; IsoId=Q13595-4; Sequence=VSP_005893, VSP_057405; Note=No experimental confirmation available.; 


uniprotID: P56180
geneSymbol: TPTE
reactome: R-HSA-1660514;
length: 551
go: ENSG00000274391;
snps: rs144333919 rs1810856 rs212146 rs150482 rs9996 rs169758
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Cancer/testis antigen 44) (CT44) (Transmembrane phosphatase with tensin homology) (Tumor antigen BJ-HCC-5)

sequence:

opentargets:
integral component of membrane [GO:0016021]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; protein dephosphorylation [GO:0006470]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha; IsoId=P56180-1; Sequence=Displayed; Name=2; Synonyms=Beta; IsoId=P56180-2; Sequence=VSP_017321; Name=3; Synonyms=Gamma; IsoId=P56180-3; Sequence=VSP_017320; Name=4; Synonyms=Delta; IsoId=P56180-4; Sequence=VSP_017319; 


uniprotID: Q5T0D9
geneSymbol: TPRG1L
length: 272
go: ENSG00000158109;
name:
Tumor protein p63-regulated gene 1-like protein (Mossy fiber terminal-associated vertebrate-specific presynaptic protein) (Protein FAM79A)

sequence:

opentargets:
calyx of Held [GO:0044305]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; synaptic vesicle [GO:0008021]; synaptic vesicle membrane [GO:0030672]; identical protein binding [GO:0042802]; regulation of synaptic transmission, glutamatergic [GO:0051966]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5T0D9-1; Sequence=Displayed; Name=2; IsoId=Q5T0D9-2; Sequence=VSP_022019; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:A8WCF8}; Peripheral membrane protein {ECO:0000250|UniProtKB:A8WCF8}. Note=Localized to the active zone presynaptic nerve terminals. {ECO:0000250|UniProtKB:A8WCF8}.


uniprotID: A6NLI5
geneSymbol: TRIM64C
name: Tripartite motif-containing protein 64C
length: 450
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
sequence:


uniprotID: O14836
geneSymbol: TNFRSF13B
reactome: R-HSA-5669034;
pdb: 1XU1;1XUT;
length: 293
go: ENSG00000240505;
snps: rs34557412 rs104894649 rs34562254
location: SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein.
name:
Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor) (CD antigen CD267)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; signaling receptor activity [GO:0038023]; adaptive immune response [GO:0002250]; B cell homeostasis [GO:0001782]; cell surface receptor signaling pathway [GO:0007166]; hematopoietic progenitor cell differentiation [GO:0002244]; negative regulation of B cell proliferation [GO:0030889]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O14836-1; Sequence=Displayed; Name=2; IsoId=O14836-2; Sequence=VSP_013798; Name=3; IsoId=O14836-3; Sequence=VSP_054184, VSP_054185; Note=No experimental confirmation available.; 


uniprotID: Q9NSU2
geneSymbol: TREX1
reactome: R-HSA-3248023;R-HSA-3270619;
length: 314
go: ENSG00000213689;
name:
Three-prime repair exonuclease 1 (EC 3.1.11.2) (3'-5' exonuclease TREX1) (Deoxyribonuclease III) (DNase III)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; nuclear envelope [GO:0005635]; 3'-5' exonuclease activity [GO:0008408]; 3'-5'-exodeoxyribonuclease activity [GO:0008296]; adenyl deoxyribonucleotide binding [GO:0032558]; double-stranded DNA binding [GO:0003690]; exodeoxyribonuclease III activity [GO:0008853]; metal ion binding [GO:0046872]; MutLalpha complex binding [GO:0032405]; MutSalpha complex binding [GO:0032407]; protein homodimerization activity [GO:0042803]; single-stranded DNA binding [GO:0003697]; cellular response to interferon-beta [GO:0035458]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; mismatch repair [GO:0006298]; regulation of type I interferon production [GO:0032479]

snps:
rs121908117 rs72556554 rs79993407 rs762011967 rs1416519719 rs78846775 rs78408272 rs113107733 rs72556555 rs112741962 rs55999987 rs148833270 rs76224909 rs370504038 rs780022923 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=3; IsoId=Q9NSU2-3; Sequence=Displayed; Name=1; IsoId=Q9NSU2-1; Sequence=VSP_059279; Name=2; IsoId=Q9NSU2-2; Sequence=VSP_010445; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the cytoplasm through the C-terminal region (By similarity). In response to DNA damage, translocates to the nucleus where it is specifically recruited to replication foci. Translocation to the nucleus also occurs during GZMA-mediated cell death. {ECO:0000250}.


uniprotID: P31314
geneSymbol: TLX1
length: 330
go: ENSG00000107807;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
T-cell leukemia homeobox protein 1 (Homeobox protein Hox-11) (Proto-oncogene TCL-3) (T-cell leukemia/lymphoma protein 3)

sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; multicellular organism development [GO:0007275]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P31314-1; Sequence=Displayed; Name=2; IsoId=P31314-2; Sequence=VSP_043068; Note=No experimental confirmation available.; 


uniprotID: P17152
geneSymbol: TMEM11
reactome: R-HSA-8949613;
name: Transmembrane protein 11, mitochondrial (Protein PM1) (Protein PMI)
length: 192
go: ENSG00000178307;
sequence:
MAAWGRRRLGPGSSGGSARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYISLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; integral component of plasma membrane [GO:0005887]; mitochondrion [GO:0005739]; inner mitochondrial membrane organization [GO:0007007]; mitochondrion organization [GO:0007005]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21274005}; Multi-pass membrane protein {ECO:0000269|PubMed:21274005}.


uniprotID: Q96HA7
geneSymbol: TONSL
pdb: 5JA4;
length: 1378
go: ENSG00000160949;
snps: rs2229314 rs2229315 rs7830832 rs4925856
name:
Tonsoku-like protein (Inhibitor of kappa B-related protein) (I-kappa-B-related protein) (IkappaBR) (NF-kappa-B inhibitor-like protein 2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; histone binding [GO:0042393]; transcription corepressor activity [GO:0003714]; cytoplasmic sequestering of transcription factor [GO:0042994]; double-strand break repair via homologous recombination [GO:0000724]; replication fork processing [GO:0031297]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96HA7-1; Sequence=Displayed; Name=2; IsoId=Q96HA7-2; Sequence=VSP_032686; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.


uniprotID: P0DI81
geneSymbol: TRAPPC2
reactome: R-HSA-204005;R-HSA-8876198;
name: Trafficking protein particle complex subunit 2 (Sedlin)
length: 140
go: ENSG00000196459;ENSG00000256060;
snps: rs769218264 rs104894948
sequence:
MSGSFYFVIVGHHDNPVFEMEFLPAGKAESKDDHRHLNQFIAHAALDLVDENMWLSNNMYLKTVDKFNEWFVSAFVTAGHMRFIMLHDIRQEDGIKNFFTDVYDLYIKFSMNPFYEPNSPIRSSAFDRKVQFLGKKHLLS

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; TRAPP complex [GO:0030008]; ion channel binding [GO:0044325]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; transcription factor binding [GO:0008134]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]; regulation of transcription, DNA-templated [GO:0006355]; skeletal system development [GO:0001501]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Major; IsoId=P0DI81-1, O14582-1; Sequence=Displayed; Name=2; IsoId=P0DI81-2, O14582-2; Sequence=VSP_041681, VSP_006040, VSP_041682; Name=3; IsoId=P0DI81-3; Sequence=VSP_041681; 

location:
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:11031107}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:11031107}. Nucleus {ECO:0000269|PubMed:20498720, ECO:0000269|PubMed:25918224}. Cytoplasm {ECO:0000269|PubMed:20498720}. Note=Localized in perinuclear granular structures. {ECO:0000269|PubMed:11031107}.


uniprotID: Q13472
geneSymbol: TOP3A
pdb: 4CGY;4CHT;
name: DNA topoisomerase 3-alpha (EC 5.99.1.2) (DNA topoisomerase III alpha)
length: 1001
go: ENSG00000177302;
snps: rs28671051 rs9909732 rs9911283
reactome:
R-HSA-5685938;R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;R-HSA-912446;

sequence:

opentargets:
chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; DNA binding [GO:0003677]; DNA topoisomerase activity [GO:0003916]; DNA topoisomerase type I activity [GO:0003917]; zinc ion binding [GO:0008270]; DNA replication [GO:0006260]; DNA topological change [GO:0006265]; meiotic cell cycle [GO:0051321]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Long; IsoId=Q13472-1; Sequence=Displayed; Name=Short; IsoId=Q13472-2; Sequence=VSP_006524; Name=3; IsoId=Q13472-3; Sequence=VSP_054189; Note=No experimental confirmation available.; 


uniprotID: Q9Y296
geneSymbol: TRAPPC4
reactome: R-HSA-204005;R-HSA-3000170;R-HSA-8876198;
pdb: 2J3T;2JSN;2ZMV;
length: 219
go: ENSG00000196655;
drug: DB08342;
snps: rs11640
name:
Trafficking protein particle complex subunit 4 (Hematopoietic stem/progenitor cell protein 172) (Synbindin) (TRS23 homolog)

sequence:

opentargets:
cytosol [GO:0005829]; dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; Golgi stack [GO:0005795]; synapse [GO:0045202]; synaptic vesicle [GO:0008021]; TRAPP complex [GO:0030008]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; COPII vesicle coating [GO:0048208]; dendrite development [GO:0016358]; ER to Golgi vesicle-mediated transport [GO:0006888]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y296-1; Sequence=Displayed; Name=2; IsoId=Q9Y296-2; Sequence=VSP_056348; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.


uniprotID: P67936
geneSymbol: TPM4
reactome: R-HSA-390522;R-HSA-445355;
name: Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
length: 248
go: ENSG00000167460;
sequence:

opentargets:
actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; muscle thin filament tropomyosin [GO:0005862]; podosome [GO:0002102]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; structural constituent of muscle [GO:0008307]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; osteoblast differentiation [GO:0001649]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P67936-1, P07226-1; Sequence=Displayed; Name=2; IsoId=P67936-2, P07226-2; Sequence=VSP_006611; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P09495}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P09495}.


uniprotID: Q8IUR0
geneSymbol: TRAPPC5
reactome: R-HSA-204005;R-HSA-8876198;
name: Trafficking protein particle complex subunit 5
length: 188
go: ENSG00000181029;
drug: DB08342;
snps: rs6952
sequence:
MEARFTRGKSALLERALARPRTEVSLSAFALLFSELVQHCQSRVFSVAELQSRLAALGRQVGARVLDALVAREKGARRETKVLGALLFVKGAVWKALFGKEADKLEQANDDARTFYIIEREPLINTYISVPKENSTLNCASFTAGIVEAVLTHSGFPAKVTAHWHKGTTLMIKFEEAVIARDRALEGR

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi membrane [GO:0000139]; TRAPP complex [GO:0030008]; TRAPPI protein complex [GO:1990070]; TRAPPII protein complex [GO:1990071]; TRAPPIII protein complex [GO:1990072]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; COPII vesicle coating [GO:0048208]; ER to Golgi vesicle-mediated transport [GO:0006888]

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.


uniprotID: O43280
geneSymbol: TREH
reactome: R-HSA-189085;
name: Trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase)
length: 583
go: ENSG00000118094;
snps: rs2276065 rs11827611 rs2276064 rs6589671 rs6589670
sequence:

opentargets:
anchored component of membrane [GO:0031225]; anchored component of plasma membrane [GO:0046658]; extracellular exosome [GO:0070062]; alpha,alpha-trehalase activity [GO:0004555]; animal organ morphogenesis [GO:0009887]; trehalose catabolic process [GO:0005993]; trehalose metabolic process [GO:0005991]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43280-1; Sequence=Displayed; Name=2; IsoId=O43280-2; Sequence=VSP_035440; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P19813}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P19813}.


uniprotID: B7Z8K6
geneSymbol: TRDC
pdb: 1HXM;
name: T-cell receptor delta chain C region
length: 153
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
SQPHTKPSVFVMKNGTNVACLVKEFYPKDIRINLVSSKKITEFDPAIVISPSGKYNAVKLGKYEDSNSVTCSVQHDNKTVHSTDFEVKTDSTDHVKPKETENTKQPSKSCHKPKAIVHTEKVNMMSLTVLGLRMLFAKTVAVNFLLTAKLFFL

opentargets:
external side of plasma membrane [GO:0009897]; immunoglobulin complex, circulating [GO:0042571]; integral component of membrane [GO:0016021]; antigen binding [GO:0003823]; immunoglobulin receptor binding [GO:0034987]; B cell receptor signaling pathway [GO:0050853]; complement activation, classical pathway [GO:0006958]; defense response to bacterium [GO:0042742]; innate immune response [GO:0045087]; phagocytosis, engulfment [GO:0006911]; phagocytosis, recognition [GO:0006910]; positive regulation of B cell activation [GO:0050871]


uniprotID: Q9Y584
geneSymbol: TIMM22
reactome: R-HSA-1268020;
name: Mitochondrial import inner membrane translocase subunit Tim22 (Testis-expressed protein 4)
length: 194
go: ENSG00000177370;
sequence:
MAAAAPNAGGSAPETAGSAEAPLQYSLLLQYLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIEKAMESCAFKAALACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAKEVLKDMGQRGMSYAKNFAIVGAMFSCTECLIESYRGTSDWKNSVISGCITGGAIGFRAGLKAGAIGCGGFAAFSAAIDYYLR

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; TIM22 mitochondrial import inner membrane insertion complex [GO:0042721]; mitochondrion targeting sequence binding [GO:0030943]; protein transmembrane transporter activity [GO:0008320]; protein import into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:27265872}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q12893
geneSymbol: TMEM115
reactome: R-HSA-6807878;
name: Transmembrane protein 115 (Placental protein 6) (Protein PL6)
length: 351
go: ENSG00000126062;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi cisterna membrane [GO:0032580]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; ER to Golgi vesicle-mediated transport [GO:0006888]; negative regulation of cell proliferation [GO:0008285]; protein glycosylation [GO:0006486]; protein transport [GO:0015031]; retrograde vesicle-mediated transport, Golgi to ER [GO:0006890]

location:
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:17973242, ECO:0000269|PubMed:24806965}; Multi-pass membrane protein {ECO:0000303|PubMed:24806965}.


uniprotID: C9JI98
geneSymbol: TMEM238
name: Transmembrane protein 238
length: 176
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MAAAPAVCASQGSPPGAPSAPAAAPAPAAGLGRCRMALLLAVALDVAGMAALLTGVFAQLQVRGRDFGDLLIYSGALLVFLSLLGWILWYTGNIEISRQELERDYGLRPSALARLARKLSRRWSAPAAAGQRPAPGSRRARRAARAPPPPAAGSRRVRLQLATLEAGPGAAGAGSE


uniprotID: P40238
geneSymbol: MPL
reactome: R-HSA-76009;
length: 635
go: ENSG00000117400;
drug: DB06210;DB05332;DB05930;
name:
Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)

sequence:

opentargets:
cell surface [GO:0009986]; Golgi apparatus [GO:0005794]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; plasma membrane [GO:0005886]; thrombopoietin receptor activity [GO:0038164]; transmembrane signaling receptor activity [GO:0004888]; basophil homeostasis [GO:1990960]; cell proliferation [GO:0008283]; cell surface receptor signaling pathway [GO:0007166]; cellular response to hypoxia [GO:0071456]; eosinophil homeostasis [GO:1990959]; monocyte homeostasis [GO:0035702]; neutrophil homeostasis [GO:0001780]; platelet aggregation [GO:0070527]; positive regulation of lymphocyte proliferation [GO:0050671]; positive regulation of platelet formation [GO:1905221]

snps:
rs17292650 rs6087 rs763568293 rs28928907 rs750046020 rs12731981 rs758428763 rs6088 rs28928908 rs1006158872 rs121913614 rs121913616 rs121913615 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=C-mpl-P; IsoId=P40238-1; Sequence=Displayed; Name=2; Synonyms=C-mpl-K; IsoId=P40238-2; Sequence=VSP_001734, VSP_001735; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25538044}; Single-pass type I membrane protein. Golgi apparatus {ECO:0000269|PubMed:25538044}. Cell surface {ECO:0000269|PubMed:25538044}.


uniprotID: P00750
geneSymbol: PLAT
reactome: R-HSA-186797;R-HSA-75205;
pdb: 1A5H;1BDA;1PK2;1PML;1RTF;1TPG;1TPK;1TPM;1TPN;5BRR;
length: 562
go: ENSG00000104368;
drug: DB07684;DB00513;DB06404;DB09228;DB01050;DB01088;DB00013;
snps: rs8178733 rs8178747 rs8178748 rs2020921
location: SUBCELLULAR LOCATION: Secreted, extracellular space.
name:
Tissue-type plasminogen activator (t-PA) (t-plasminogen activator) (tPA) (EC 3.4.21.68) (Alteplase) (Reteplase) [Cleaved into: Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B]

sequence:

opentargets:
apical part of cell [GO:0045177]; cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; glutamatergic synapse [GO:0098978]; Schaffer collateral - CA1 synapse [GO:0098685]; secretory granule [GO:0030141]; phosphoprotein binding [GO:0051219]; serine-type endopeptidase activity [GO:0004252]; signaling receptor binding [GO:0005102]; blood coagulation [GO:0007596]; cellular protein modification process [GO:0006464]; fibrinolysis [GO:0042730]; negative regulation of proteolysis [GO:0045861]; plasminogen activation [GO:0031639]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; proteolysis [GO:0006508]; response to hypoxia [GO:0001666]; smooth muscle cell migration [GO:0014909]; trans-synaptic signaling by BDNF, modulating synaptic transmission [GO:0099183]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Long; IsoId=P00750-1; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=P00750-2; Sequence=VSP_005411, VSP_005412; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P00750-3; Sequence=VSP_015957; Note=No experimental confirmation available.; Name=4; Synonyms=Neonatal; IsoId=P00750-4; Sequence=VSP_028029, VSP_028030; Note=No experimental confirmation available.; 


uniprotID: Q86W33
geneSymbol: TPRA1
length: 373
go: ENSG00000163870;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Transmembrane protein adipocyte-associated 1 (Integral membrane protein GPR175) (Transmembrane protein 227)

sequence:

opentargets:
integral component of membrane [GO:0016021]; G protein-coupled receptor activity [GO:0004930]; aging [GO:0007568]; lipid metabolic process [GO:0006629]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86W33-1; Sequence=Displayed; Name=2; IsoId=Q86W33-2; Sequence=VSP_016932, VSP_016933; Name=3; IsoId=Q86W33-3; Sequence=VSP_016934, VSP_016935; Note=No experimental confirmation available.; 


uniprotID: Q96A98
geneSymbol: PTH2
reactome: R-HSA-373080;R-HSA-418555;
name: Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2)
length: 100
go: ENSG00000142538;
location: SUBCELLULAR LOCATION: Secreted.
sequence:
METRQVSRSPRVRLLLLLLLLLVVPWGVRTASGVALPPVGVLSLRPPGRAWADPATPRPRRSLALADDAAFRERARLLAALERRHWLNSYMHKLLVLDAP

opentargets:
extracellular region [GO:0005576]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]


uniprotID: Q6P2H8
geneSymbol: TMEM53
name: Transmembrane protein 53
length: 277
go: ENSG00000126106;
opentargets: integral component of membrane [GO:0016021]; nucleus [GO:0005634]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P2H8-1; Sequence=Displayed; Name=2; IsoId=Q6P2H8-2; Sequence=VSP_024446; 


uniprotID: P06753
geneSymbol: TPM3
reactome: R-HSA-390522;R-HSA-445355;
name: Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)
length: 285
go: ENSG00000143549;
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}.
sequence:

opentargets:
actin cytoskeleton [GO:0015629]; actin filament [GO:0005884]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; muscle thin filament tropomyosin [GO:0005862]; stress fiber [GO:0001725]; actin filament binding [GO:0051015]; actin filament organization [GO:0007015]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]

snps:
rs199474711 rs80358247 rs199474713 rs121964853 rs121964854 rs121964854 rs121964852 rs199474715 rs199474716 rs199474717 rs199474718 rs797046047 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Skeletal muscle; IsoId=P06753-1; Sequence=Displayed; Name=2; Synonyms=Cytoskeletal, TM30nm; IsoId=P06753-2; Sequence=VSP_006604, VSP_006605, VSP_006606; Note=Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS. Ref.8 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues. {ECO:0000244|PubMed:19608861, ECO:0000269|Ref.10, ECO:0000269|Ref.9, ECO:0000305}; Name=3; IsoId=P06753-3; Sequence=VSP_006604, VSP_006605, VSP_006607; Note=Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS. {ECO:0000244|PubMed:19608861, ECO:0000269|Ref.10, ECO:0000269|Ref.9}; Name=4; IsoId=P06753-4; Sequence=VSP_047302, VSP_047303, VSP_047304, VSP_047305, VSP_047306; Note=Gene prediction based on EST data.; Name=5; IsoId=P06753-5; Sequence=VSP_047302, VSP_047303, VSP_047304, VSP_006606; Note=Gene prediction based on EST data. {ECO:0000244|PubMed:19608861}; Name=6; IsoId=P06753-6; Sequence=VSP_006604, VSP_006605; Note=No experimental confirmation available. {ECO:0000244|PubMed:19608861}; Name=7; IsoId=P06753-7; Sequence=VSP_054792, VSP_006606; Note=No experimental confirmation available. Gene prediction based on EST data. {ECO:0000244|PubMed:19608861}; 


uniprotID: Q969Z4
geneSymbol: RELT
name: Tumor necrosis factor receptor superfamily member 19L (Receptor expressed in lymphoid tissues)
length: 430
go: ENSG00000054967;
snps: rs12362779
sequence:

opentargets:
integral component of membrane [GO:0016021]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; apoptotic process [GO:0006915]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16389068}; Single-pass type I membrane protein {ECO:0000269|PubMed:16389068}. Cytoplasm {ECO:0000269|PubMed:16389068}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22052202}.


uniprotID: Q6ZUI0
geneSymbol: TPRG1
name: Tumor protein p63-regulated gene 1 protein (Protein FAM79B)
length: 275
go: ENSG00000188001;
opentargets: cytoplasm [GO:0005737]
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CB49}.
sequence:


uniprotID: A6NMA1
geneSymbol: TRPC5OS
name: Putative uncharacterized protein TRPC5OS (TRPC5 opposite strand protein) (TRPC5-antisense RNA 1)
length: 111
go: ENSG00000204025;
sequence:
MDSVLIHVLIDGLVACVAQLIRIADELLQFILQVQEVPYVEENGRAEETEADAPLPEEPSLPDLPDLSDLDSILTPREDEDLIFDIDQAMLDMDNLYEDTVSGINDDLTGD


uniprotID: Q9NQ34
geneSymbol: TMEM9B
name: Transmembrane protein 9B
length: 198
go: ENSG00000175348;
sequence:
MATLWGGLLRLGSLLSLSCLALSVLLLAQLSDAAKNFEDVRCKCICPPYKENSGHIYNKNISQKDCDCLHVVEPMPVRGPDVEAYCLRCECKYEERSSVTIKVTIIIYLSILGLLLLYMVYLTLVEPILKRRLFGHAQLIQSDDDIGDHQPFANAHDVLARSRSRANVLNKVEYAQQRWKLQVQEQRKSVFDRHVVLS

opentargets:
early endosome membrane [GO:0031901]; integral component of membrane [GO:0016021]; lysosomal membrane [GO:0005765]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NQ34-1; Sequence=Displayed; Name=2; IsoId=Q9NQ34-2; Sequence=VSP_055294; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:18541524}; Single-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18541524}; Single-pass membrane protein {ECO:0000255}.


uniprotID: Q7Z410
geneSymbol: TMPRSS9
length: 1059
go: ENSG00000178297;
opentargets: integral component of plasma membrane [GO:0005887]; serine-type endopeptidase activity [GO:0004252]
snps: rs8100709 rs891174 rs17685098 rs10153474 rs60568869 rs735911 rs7247162
name:
Transmembrane protease serine 9 (EC 3.4.21.-) (Polyserase-I) (Polyserine protease 1) (Polyserase-1) [Cleaved into: Serase-1; Serase-2; Serase-3]

sequence:

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12886014}; Single-pass type II membrane protein {ECO:0000269|PubMed:12886014}.


uniprotID: Q6ZRR5
geneSymbol: TMEM136
name: Transmembrane protein 136
length: 245
go: ENSG00000181264;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZRR5-1; Sequence=Displayed; Name=2; IsoId=Q6ZRR5-2; Sequence=VSP_024871; Name=3; IsoId=Q6ZRR5-3; Sequence=VSP_039853; Name=4; IsoId=Q6ZRR5-4; Sequence=VSP_039853, VSP_024871; Note=No experimental confirmation available.; 


uniprotID: Q6ZTW0
geneSymbol: TPGS1
reactome: R-HSA-8955332;
name: Tubulin polyglutamylase complex subunit 1 (PGs1)
length: 290
go: ENSG00000141933;
sequence:

opentargets:
axon [GO:0030424]; centrosome [GO:0005813]; cytoplasm [GO:0005737]; dendrite [GO:0030425]; microtubule [GO:0005874]; motile cilium [GO:0031514]; microtubule binding [GO:0008017]; tubulin-glutamic acid ligase activity [GO:0070740]; adult behavior [GO:0030534]; chemical synaptic transmission [GO:0007268]; multicellular organism development [GO:0007275]; protein polyglutamylation [GO:0018095]; sperm axoneme assembly [GO:0007288]; vesicle localization [GO:0051648]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZTW0-1; Sequence=Displayed; Name=2; IsoId=Q6ZTW0-2; Sequence=VSP_020401; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, axon. Cell projection, dendrite. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with microtubules from neurites, centrosomes, basal bodies and axonemes. {ECO:0000250}.


uniprotID: O14657
geneSymbol: TOR1B
reactome: R-HSA-8856825;
name: Torsin-1B (Torsin ATPase-1B) (EC 3.6.4.-) (Torsin family 1 member B)
length: 336
go: ENSG00000136816;
snps: rs10988518
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; chaperone cofactor-dependent protein refolding [GO:0051085]; endoplasmic reticulum organization [GO:0007029]; nuclear membrane organization [GO:0071763]; protein homooligomerization [GO:0051260]; response to unfolded protein [GO:0006986]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15147511}. Nucleus membrane {ECO:0000269|PubMed:15147511}.


uniprotID: O75365
geneSymbol: PTP4A3
pdb: 1R6H;1V3A;2MBC;5TSR;
length: 173
go: ENSG00000184489;
name:
Protein tyrosine phosphatase type IVA 3 (EC 3.1.3.48) (PRL-R) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3)

sequence:
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM

opentargets:
cytoplasm [GO:0005737]; early endosome [GO:0005769]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; prenylated protein tyrosine phosphatase activity [GO:0004727]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; cellular response to leukemia inhibitory factor [GO:1990830]; endothelial cell migration [GO:0043542]; Notch signaling pathway [GO:0007219]; positive regulation of establishment of protein localization [GO:1904951]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of vascular permeability [GO:0043117]; regulation of transcription, DNA-templated [GO:0006355]; regulation of vascular endothelial growth factor signaling pathway [GO:1900746]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=O75365-1; Sequence=Displayed; Name=2; IsoId=O75365-2; Sequence=VSP_014407; Note=Unstructured and inactive.; Name=3; Synonyms=short; IsoId=O75365-3; Sequence=VSP_014406; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782572}. Early endosome {ECO:0000269|PubMed:12782572}.


uniprotID: O94811
geneSymbol: TPPP
length: 219
go: ENSG00000171368;
name:
Tubulin polymerization-promoting protein (TPPP) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule [GO:0005874]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; microtubule binding [GO:0008017]; tubulin binding [GO:0015631]; microtubule bundle formation [GO:0001578]; microtubule polymerization [GO:0046785]; positive regulation of protein complex assembly [GO:0031334]; positive regulation of protein polymerization [GO:0032273]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies.


uniprotID: Q6XPS3
geneSymbol: TPTE2
reactome: R-HSA-1660514;
length: 522
go: ENSG00000132958;
snps: rs2497218 rs2497218
name:
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (Lipid phosphatase TPIP) (TPTE and PTEN homologous inositol lipid phosphatase)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [GO:0016314]; phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity [GO:0051800]; protein tyrosine phosphatase activity [GO:0004725]; protein tyrosine/serine/threonine phosphatase activity [GO:0008138]; phosphatidylinositol biosynthetic process [GO:0006661]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=TPIP gamma; IsoId=Q6XPS3-1; Sequence=Displayed; Name=2; IsoId=Q6XPS3-2; Sequence=VSP_017324; Name=3; Synonyms=TPIP alpha; IsoId=Q6XPS3-3; Sequence=VSP_017323, VSP_017324; Name=4; Synonyms=TPIP beta; IsoId=Q6XPS3-4; Sequence=VSP_017322, VSP_017325; Name=5; IsoId=Q6XPS3-5; Sequence=VSP_044506; Note=No experimental confirmation available.; Name=6; Synonyms=TPIP-C2; IsoId=Q6XPS3-6; Sequence=VSP_047569; Note=Expressed in testis, strongly inhibits cell growth in HeLa cells.; Name=7; IsoId=Q6XPS3-7; Sequence=VSP_053978; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11716755}; Multi-pass membrane protein {ECO:0000269|PubMed:11716755}.; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.


uniprotID: Q96J77
geneSymbol: TPD52L3
name: Tumor protein D55 (hD55) (Testis development protein NYD-SP25) (Tumor protein D52-like 3)
length: 140
go: ENSG00000170777;
snps: rs3847262
sequence:
MPHARTETSVGTYESHSTSELEDLTEPEQRELKTKLTKLEAEIVTLRHVLAAKERRCGELKRKLGLTALVGLRQNLSKSWLDVQVSNTYVKQKTSAALSTMGTLICRKLGGVKKSATFRSFEGLMGTIKSKVSGGKRAWP

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96J77-1; Sequence=Displayed; Name=2; IsoId=Q96J77-2; Sequence=VSP_027114; Name=3; IsoId=Q96J77-3; Sequence=VSP_027113; 


uniprotID: Q9NPI0
geneSymbol: TMEM138
name: Transmembrane protein 138
length: 162
go: ENSG00000149483;
snps: rs387907132 rs387907134 rs387907133 rs387907135
sequence:
MLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMFFNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQMLFVFQRLAAVLYCYFYKRTAVRLGDPHFYQDSLWLRKEFMQVRR

opentargets:
cilium [GO:0005929]; integral component of membrane [GO:0016021]; vacuolar membrane [GO:0005774]; cilium assembly [GO:0060271]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NPI0-1; Sequence=Displayed; Name=2; IsoId=Q9NPI0-2; Sequence=VSP_024891, VSP_024892; Note=No experimental confirmation available.; Name=3; IsoId=Q9NPI0-3; Sequence=VSP_042588; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:22282472}; Multi-pass membrane protein {ECO:0000269|PubMed:22282472}. Cell projection, cilium {ECO:0000269|PubMed:22282472}. Note=Localizes to vesicles en route to the base of cilium.


uniprotID: Q86X19
geneSymbol: TMEM17
name: Transmembrane protein 17
length: 198
go: ENSG00000186889;
snps: rs17854454 rs201339749
sequence:
MELPDPVRQRLGNFSRAVFSDSNRTGPESNEGPENEMVSSLALQMSLYFNTYYFPLWWVSSIMMLHMKYSILPDYYKFIVITVIILITLIEAIRLYLGYVGNLQEKVPELAGFWLLSLLLQLPLILFLLFNEGLTNLPLEKAIHIIFTLFLAFQVVAAFLTLRKMVNQLAVRFHLQDFDRLSANRGDMRRMRSCIEEI

opentargets:
ciliary membrane [GO:0060170]; ciliary transition zone [GO:0035869]; integral component of membrane [GO:0016021]; MKS complex [GO:0036038]; cilium assembly [GO:0060271]; non-motile cilium assembly [GO:1905515]; smoothened signaling pathway [GO:0007224]

location:
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localizes to the transition zone of primary cilia. {ECO:0000250}.


uniprotID: Q9UL52
geneSymbol: TMPRSS11E
pdb: 2OQ5;
length: 423
go: ENSG00000087128;
snps: rs976002
name:
Transmembrane protease serine 11E (EC 3.4.21.-) (Serine protease DESC1) (Transmembrane protease serine 11E2) [Cleaved into: Transmembrane protease serine 11E non-catalytic chain; Transmembrane protease serine 11E catalytic chain]

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; serine-type endopeptidase activity [GO:0004252]; serine-type peptidase activity [GO:0008236]; cognition [GO:0050890]; proteolysis [GO:0006508]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5S248}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q5S248}.; SUBCELLULAR LOCATION: Transmembrane protease serine 11E catalytic chain: Secreted {ECO:0000250|UniProtKB:Q5S248}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q5S248}.


uniprotID: Q969M1
geneSymbol: TOMM40L
name: Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like)
length: 308
go: ENSG00000158882;
sequence:

opentargets:
mitochondrial outer membrane translocase complex [GO:0005742]; pore complex [GO:0046930]; protein-containing complex [GO:0032991]; mitochondrion targeting sequence binding [GO:0030943]; porin activity [GO:0015288]; preprotein binding [GO:0070678]; protein transmembrane transporter activity [GO:0008320]; ion transport [GO:0006811]; protein import into mitochondrial matrix [GO:0030150]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969M1-1; Sequence=Displayed; Name=2; IsoId=Q969M1-2; Sequence=VSP_054885; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.


uniprotID: Q06643
geneSymbol: LTB
reactome: R-HSA-5668541;R-HSA-5676594;
pdb: 4MXW;
length: 244
go: ENSG00000227507;
snps: rs3093554 rs4647186 rs4647187 rs3093555 rs2229699
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
name:
Lymphotoxin-beta (LT-beta) (Tumor necrosis factor C) (TNF-C) (Tumor necrosis factor ligand superfamily member 3)

sequence:

opentargets:
extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; signaling receptor binding [GO:0005102]; tumor necrosis factor receptor binding [GO:0005164]; cell-cell signaling [GO:0007267]; gene expression [GO:0010467]; immune response [GO:0006955]; lymph node development [GO:0048535]; positive regulation of interleukin-12 biosynthetic process [GO:0045084]; signal transduction [GO:0007165]; skin development [GO:0043588]; tumor necrosis factor-mediated signaling pathway [GO:0033209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q06643-1; Sequence=Displayed; Name=2; IsoId=Q06643-2; Sequence=VSP_006441, VSP_006442; 


uniprotID: O14656
geneSymbol: TOR1A
reactome: R-HSA-8856825;
pdb: 5J1S;5J1T;
name: Torsin-1A (Dystonia 1 protein) (Torsin ATPase-1A) (EC 3.6.4.-) (Torsin family 1 member A)
length: 332
go: ENSG00000136827;
snps: rs267607134 rs1801968 rs727502811 rs80358233 rs80358235
sequence:

opentargets:
cell junction [GO:0030054]; cytoplasmic vesicle membrane [GO:0030659]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]; growth cone [GO:0030426]; intracellular membrane-bounded organelle [GO:0043231]; membrane [GO:0016020]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; secretory granule [GO:0030141]; synaptic vesicle [GO:0008021]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; cytoskeletal protein binding [GO:0008092]; kinesin binding [GO:0019894]; misfolded protein binding [GO:0051787]; unfolded protein binding [GO:0051082]; cell adhesion [GO:0007155]; chaperone cofactor-dependent protein refolding [GO:0051085]; chaperone-mediated protein folding [GO:0061077]; chaperone-mediated protein transport [GO:0072321]; ER-associated misfolded protein catabolic process [GO:0071712]; intermediate filament cytoskeleton organization [GO:0045104]; neuron projection development [GO:0031175]; nuclear envelope organization [GO:0006998]; nuclear membrane organization [GO:0071763]; organelle organization [GO:0006996]; positive regulation of synaptic vesicle endocytosis [GO:1900244]; protein deneddylation [GO:0000338]; protein homooligomerization [GO:0051260]; protein localization to nucleus [GO:0034504]; regulation of dopamine uptake involved in synaptic transmission [GO:0051584]; regulation of protein localization to cell surface [GO:2000008]; response to oxidative stress [GO:0006979]; synaptic vesicle transport [GO:0048489]; wound healing, spreading of cells [GO:0044319]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14656-1; Sequence=Displayed; Name=2; IsoId=O14656-2; Sequence=VSP_026605; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cytoplasm, cytoskeleton. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. {ECO:0000250}.


uniprotID: P28289
geneSymbol: TMOD1
reactome: R-HSA-390522;
pdb: 4PKG;4PKH;4PKI;4Z8G;4Z94;
name: Tropomodulin-1 (Erythrocyte tropomodulin) (E-Tmod)
length: 359
go: ENSG00000136842;
sequence:

opentargets:
actin filament [GO:0005884]; cortical cytoskeleton [GO:0030863]; cytosol [GO:0005829]; membrane [GO:0016020]; myofibril [GO:0030016]; sarcomere [GO:0030017]; striated muscle thin filament [GO:0005865]; actin binding [GO:0003779]; actin filament binding [GO:0051015]; tropomyosin binding [GO:0005523]; adult locomotory behavior [GO:0008344]; lens fiber cell development [GO:0070307]; muscle contraction [GO:0006936]; muscle filament sliding [GO:0030049]; myofibril assembly [GO:0030239]; pointed-end actin filament capping [GO:0051694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P28289-1; Sequence=Displayed; Name=2; IsoId=P28289-2; Sequence=VSP_056863, VSP_056864; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25250574}. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}.


uniprotID: Q6ZWK6
geneSymbol: TMPRSS11F
name: Transmembrane protease serine 11F (EC 3.4.21.-) (Airway trypsin-like protease 4)
length: 438
go: ENSG00000198092;
snps: rs10030708 rs1438391
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; serine-type endopeptidase activity [GO:0004252]


uniprotID: Q9HCJ0
geneSymbol: TNRC6C
pdb: 2DKL;2X04;3KTP;
name: Trinucleotide repeat-containing gene 6C protein
length: 1690
go: ENSG00000078687;
snps: rs34293811
reactome:
R-HSA-1912408;R-HSA-2559580;R-HSA-2559585;R-HSA-4086398;R-HSA-426496;R-HSA-5628897;R-HSA-5687128;R-HSA-8934593;R-HSA-8936459;R-HSA-8943723;R-HSA-8948700;R-HSA-9018519;

sequence:

opentargets:
cytosol [GO:0005829]; micro-ribonucleoprotein complex [GO:0035068]; nucleoplasm [GO:0005654]; P-body [GO:0000932]; RNA binding [GO:0003723]; gene silencing by miRNA [GO:0035195]; miRNA mediated inhibition of translation [GO:0035278]; negative regulation of gene expression [GO:0010629]; positive regulation of gene expression [GO:0010628]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; posttranscriptional gene silencing by RNA [GO:0035194]; regulation of megakaryocyte differentiation [GO:0045652]; Wnt signaling pathway, calcium modulating pathway [GO:0007223]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HCJ0-1; Sequence=Displayed; Name=2; IsoId=Q9HCJ0-2; Sequence=VSP_054230, VSP_023322; 


uniprotID: Q8WZ04
geneSymbol: LRTOMT
reactome: R-HSA-379397;
name: Transmembrane O-methyltransferase (EC 2.1.1.6) (Catechol O-methyltransferase 2) (Protein LRTOMT2)
length: 291
go: ENSG00000184154;
snps: rs891068154 rs1372399805 rs137853185 rs137853186 rs137853187 rs758115449 rs61741195
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; catechol O-methyltransferase activity [GO:0016206]; L-dopa O-methyltransferase activity [GO:0102084]; orcinol O-methyltransferase activity [GO:0102938]; auditory receptor cell development [GO:0060117]; catecholamine catabolic process [GO:0042424]; developmental process [GO:0032502]; dopamine metabolic process [GO:0042417]; neurotransmitter catabolic process [GO:0042135]; sensory perception of sound [GO:0007605]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=D'; IsoId=Q8WZ04-1; Sequence=Displayed; Name=2; Synonyms=E'; IsoId=Q8WZ04-2; Sequence=VSP_036898; 

location:
SUBCELLULAR LOCATION: Isoform 1: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm {ECO:0000269|PubMed:28504928}. Endoplasmic reticulum {ECO:0000250|UniProtKB:A1Y9I9}. Note=Localized to the cell body of the cochlear hair cells, but is not present in the stereocilia (PubMed:28504928). Present but not restricted to the apical cistern, Hensen's body and the subsurface cistern (By similarity). {ECO:0000250|UniProtKB:A1Y9I9, ECO:0000269|PubMed:28504928}.


uniprotID: Q15785
geneSymbol: TOMM34
name: Mitochondrial import receptor subunit TOM34 (hTom34) (Translocase of outer membrane 34 kDa subunit)
length: 309
go: ENSG00000025772;
snps: rs6094061
sequence:

opentargets:
cytosol [GO:0005829]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; heat shock protein binding [GO:0031072]; protein targeting to mitochondrion [GO:0006626]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10101285}. Mitochondrion outer membrane {ECO:0000269|PubMed:10101285}; Peripheral membrane protein {ECO:0000269|PubMed:10101285}; Cytoplasmic side {ECO:0000269|PubMed:10101285}.


uniprotID: Q16890
geneSymbol: TPD52L1
reactome: R-HSA-432722;
name: Tumor protein D53 (hD53) (Tumor protein D52-like 1)
length: 204
go: ENSG00000111907;
snps: rs6905231
sequence:

opentargets:
cytoplasm [GO:0005737]; perinuclear region of cytoplasm [GO:0048471]; identical protein binding [GO:0042802]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; G2/M transition of mitotic cell cycle [GO:0000086]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of JNK cascade [GO:0046330]; positive regulation of MAP kinase activity [GO:0043406]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q16890-1; Sequence=Displayed; Name=2; IsoId=Q16890-2; Sequence=VSP_036754, VSP_036755; Name=3; IsoId=Q16890-3; Sequence=VSP_036752, VSP_036753; Name=4; Synonyms=+5hD53; IsoId=Q16890-4; Sequence=VSP_036751, VSP_036752, VSP_036753; Name=5; IsoId=Q16890-5; Sequence=VSP_036751; Note=No experimental confirmation available. Gene prediction based of partial mRNA data.; 


uniprotID: Q9BWF2
geneSymbol: TRAIP
reactome: R-HSA-983168;
pdb: 4ZTD;
length: 469
go: ENSG00000183763;
snps: rs864622784
name:
E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (RING-type E3 ubiquitin transferase TRAIP) (TRAF-interacting protein)

sequence:

opentargets:
nucleolus [GO:0005730]; perinuclear region of cytoplasm [GO:0048471]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; apoptotic process [GO:0006915]; cell proliferation [GO:0008283]; negative regulation of interferon-beta production [GO:0032688]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of tumor necrosis factor-mediated signaling pathway [GO:0010804]; signal transduction [GO:0007165]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus {ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:26595769}. Nucleus, nucleolus {ECO:0000269|PubMed:14676304, ECO:0000269|PubMed:24553286}. Note=In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci. After UV irradiation, rapidly localizes to sites of DNA damage, where it colocalizes with phosphorylated histone H2AX (gamma-H2AX) and RPA2. {ECO:0000269|PubMed:26595769}.


uniprotID: P51854
geneSymbol: TKTL1
name: Transketolase-like protein 1 (EC 2.2.1.1) (Transketolase 2) (TK 2) (Transketolase-related protein)
length: 596
go: ENSG00000007350;
snps: rs17855509 rs17852259
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transketolase activity [GO:0004802]; glucose catabolic process [GO:0006007]; thiamine metabolic process [GO:0006772]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Additional isoforms seem to exist.; Name=3; IsoId=P51854-3; Sequence=Displayed; Name=2; Synonyms=Brain specific; IsoId=P51854-1; Sequence=VSP_022290, VSP_022291; Name=1; Synonyms=Heart specific; IsoId=P51854-2; Sequence=Not described; Note=Lacks the N-terminal.; Name=4; IsoId=P51854-4; Sequence=VSP_022290; Note=No experimental confirmation available. Gene prediction based on partial EST data.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16465194, ECO:0000269|PubMed:16969476}. Nucleus {ECO:0000269|PubMed:16465194, ECO:0000269|PubMed:16969476}. Note=Predominantly cytoplasmic and to a lesser extent also nuclear (PubMed:16969476).


uniprotID: Q71RG4
geneSymbol: TMUB2
name: Transmembrane and ubiquitin-like domain-containing protein 2
length: 321
go: ENSG00000168591;
opentargets: integral component of membrane [GO:0016021]
snps: rs9895154
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q71RG4-1; Sequence=Displayed; Name=2; IsoId=Q71RG4-2; Sequence=VSP_019700; Name=3; IsoId=Q71RG4-3; Sequence=VSP_019700, VSP_019703, VSP_019704; Note=No experimental confirmation available.; Name=4; IsoId=Q71RG4-4; Sequence=VSP_019700, VSP_019701, VSP_019702; Note=No experimental confirmation available.; 


uniprotID: Q9Y5J7
geneSymbol: TIMM9
reactome: R-HSA-1268020;
pdb: 2BSK;
name: Mitochondrial import inner membrane translocase subunit Tim9
sequence: MAAQIPESDQIKQFKEFLGTYNKLTETCFLDCVKDFTTREVKPEETTCSEHCLQKYLKMTQRISMRFQEYHIQQNEALAAKAGLLGQPR
length: 89
go: ENSG00000100575;
opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial intermembrane space [GO:0005758]; mitochondrial intermembrane space protein transporter complex [GO:0042719]; mitochondrion [GO:0005739]; chaperone binding [GO:0051087]; protein homodimerization activity [GO:0042803]; transporter activity [GO:0005215]; zinc ion binding [GO:0008270]; chaperone-mediated protein transport [GO:0072321]; protein import into mitochondrial inner membrane [GO:0045039]; protein targeting to mitochondrion [GO:0006626]; sensory perception of sound [GO:0007605]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Peripheral membrane protein {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}; Intermembrane side {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:14726512}.


uniprotID: Q13263
geneSymbol: TRIM28
reactome: R-HSA-212436;R-HSA-3899300;
pdb: 1FP0;2RO1;2YVR;
length: 835
go: ENSG00000130726;
snps: rs56229738
name:
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)

sequence:

opentargets:
chromatin [GO:0000785]; nuclear euchromatin [GO:0005719]; nuclear heterochromatin [GO:0005720]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; chromatin binding [GO:0003682]; chromo shadow domain binding [GO:0070087]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; Krueppel-associated box domain binding [GO:0035851]; promoter-specific chromatin binding [GO:1990841]; protein kinase activity [GO:0004672]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; SUMO transferase activity [GO:0019789]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; chromatin organization [GO:0006325]; convergent extension involved in axis elongation [GO:0060028]; DNA methylation involved in embryo development [GO:0043045]; DNA repair [GO:0006281]; embryo implantation [GO:0007566]; embryonic placenta morphogenesis [GO:0060669]; epithelial to mesenchymal transition [GO:0001837]; innate immune response [GO:0045087]; negative regulation of DNA demethylation [GO:1901536]; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate [GO:0045869]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of viral release from host cell [GO:1902187]; positive regulation of DNA binding [GO:0043388]; positive regulation of DNA repair [GO:0045739]; positive regulation of methylation-dependent chromatin silencing [GO:0090309]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of transcription, DNA-templated [GO:0045893]; protein autophosphorylation [GO:0046777]; protein complex oligomerization [GO:0051259]; protein sumoylation [GO:0016925]; Ras protein signal transduction [GO:0007265]; regulation of genetic imprinting [GO:2000653]; transcription initiation from RNA polymerase II promoter [GO:0006367]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q13263-1; Sequence=Displayed; Name=2; IsoId=Q13263-2; Sequence=VSP_010898; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10330177, ECO:0000269|PubMed:17178852, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:23665872, ECO:0000269|PubMed:24741090, ECO:0000269|PubMed:9016654}. Note=Associated with centromeric heterochromatin during cell differentiation through CBX1. {ECO:0000250}.


uniprotID: P25445
geneSymbol: FAS
reactome: R-HSA-140534;R-HSA-3371378;R-HSA-5213460;R-HSA-5218900;R-HSA-6803211;R-HSA-69416;R-HSA-75157;
pdb: 1BZI;1DDF;2NA7;3EWT;3EZQ;3THM;3TJE;
length: 335
go: ENSG00000026103;
name:
Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)

sequence:

opentargets:
CD95 death-inducing signaling complex [GO:0031265]; cell surface [GO:0009986]; cytosol [GO:0005829]; death-inducing signaling complex [GO:0031264]; extracellular exosome [GO:0070062]; integral component of membrane [GO:0016021]; membrane raft [GO:0045121]; nuclear body [GO:0016604]; plasma membrane [GO:0005886]; calmodulin binding [GO:0005516]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; signaling receptor activity [GO:0038023]; transmembrane signaling receptor activity [GO:0004888]; activation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0006919]; apoptotic process [GO:0006915]; apoptotic signaling pathway [GO:0097190]; cellular response to amino acid starvation [GO:0034198]; cellular response to hyperoxia [GO:0071455]; cellular response to mechanical stimulus [GO:0071260]; extrinsic apoptotic signaling pathway [GO:0097191]; Fas signaling pathway [GO:0036337]; immune response [GO:0006955]; necroptotic signaling pathway [GO:0097527]; negative regulation of apoptotic process [GO:0043066]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of apoptotic process [GO:0043065]; positive regulation of apoptotic signaling pathway [GO:2001235]; positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [GO:2001269]; positive regulation of protein phosphorylation [GO:0001934]; protein-containing complex assembly [GO:0065003]; regulation of apoptotic process [GO:0042981]; regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902041]; regulation of stress-activated MAPK cascade [GO:0032872]; signal transduction [GO:0007165]

snps:
rs3218619 rs606231364 rs121913083 rs121913078 rs3218614 rs121913084 rs758835365 rs28362322 rs121913079 rs201072885 rs121913076 rs121913080 rs121913082 rs28929498 rs121913086 rs121913081 rs3218611 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; IsoId=P25445-1; Sequence=Displayed; Name=2; Synonyms=del2, D; IsoId=P25445-2; Sequence=VSP_006481, VSP_006482; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; Synonyms=del3, E; IsoId=P25445-3; Sequence=VSP_006483, VSP_006484; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=4; Synonyms=B; IsoId=P25445-4; Sequence=VSP_006485, VSP_006486; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=5; Synonyms=C; IsoId=P25445-5; Sequence=VSP_006487, VSP_006488; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=6; Synonyms=TMdel, A; IsoId=P25445-6; Sequence=VSP_006489; Name=7; Synonyms=FasExo8Del; IsoId=P25445-7; Sequence=VSP_045235, VSP_045236; Note=Dominant negative isoform, resistant to Fas-mediated apoptosis.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:1713127}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: Isoform 2: Secreted.; SUBCELLULAR LOCATION: Isoform 3: Secreted.; SUBCELLULAR LOCATION: Isoform 4: Secreted.; SUBCELLULAR LOCATION: Isoform 5: Secreted.; SUBCELLULAR LOCATION: Isoform 6: Secreted.


uniprotID: Q9NXH8
geneSymbol: TOR4A
reactome: R-HSA-114608;
name: Torsin-4A (Torsin family 4 member A)
length: 423
go: ENSG00000198113;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; platelet alpha granule lumen [GO:0031093]; ATP binding [GO:0005524]; platelet degranulation [GO:0002576]


uniprotID: Q56UQ5
name: TPT1-like protein
length: 140
opentargets: cytoplasm [GO:0005737]; calcium ion binding [GO:0005509]
sequence:
METVIMITYWDLISHSEMFSDSYMSQEIADGLRLEVEGKIVSRTEGNIFDSLIGGNASAEGPEGKGTESTVITGVDSVMNHHLQETSFTKEAYNKCIKDYMKSIKGKLEEQRPKRVKPFMTGAAEQIKHILANFKNYQKT


uniprotID: P47974
geneSymbol: ZFP36L2
pdb: 1RGO;
length: 494
go: ENSG00000152518;
name:
mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; AU-rich element binding [GO:0017091]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; cell proliferation [GO:0008283]; cellular response to epidermal growth factor stimulus [GO:0071364]; cellular response to fibroblast growth factor stimulus [GO:0044344]; cellular response to glucocorticoid stimulus [GO:0071385]; cellular response to granulocyte macrophage colony-stimulating factor stimulus [GO:0097011]; cellular response to transforming growth factor beta stimulus [GO:0071560]; cellular response to tumor necrosis factor [GO:0071356]; definitive hemopoiesis [GO:0060216]; ERK1 and ERK2 cascade [GO:0070371]; hemopoiesis [GO:0030097]; mRNA catabolic process [GO:0006402]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of mitotic cell cycle phase transition [GO:1901991]; negative regulation of stem cell differentiation [GO:2000737]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:1900153]; regulation of B cell differentiation [GO:0045577]; regulation of mRNA stability [GO:0043488]; response to wounding [GO:0009611]; somatic stem cell division [GO:0048103]; somatic stem cell population maintenance [GO:0035019]; T cell differentiation in thymus [GO:0033077]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P23949}. Cytoplasm {ECO:0000250|UniProtKB:P23949}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. {ECO:0000250|UniProtKB:P23949}.


uniprotID: Q7Z402
geneSymbol: TMC7
name: Transmembrane channel-like protein 7
length: 723
go: ENSG00000170537;
snps: rs17854512 rs4072393 rs55796412 rs11864159
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; ion channel activity [GO:0005216]; mechanosensitive ion channel activity [GO:0008381]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z402-1; Sequence=Displayed; Name=2; IsoId=Q7Z402-2; Sequence=VSP_054226; Note=No experimental confirmation available.; 


uniprotID: P36941
geneSymbol: LTBR
reactome: R-HSA-5668541;R-HSA-5676594;
pdb: 1RF3;4MXW;
length: 435
go: ENSG00000111321;
snps: rs35681405
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
name:
Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor) (Tumor necrosis factor C receptor) (Tumor necrosis factor receptor 2-related protein) (Tumor necrosis factor receptor type III) (TNF-RIII) (TNFR-III)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; ubiquitin protein ligase binding [GO:0031625]; apoptotic process [GO:0006915]; cellular response to mechanical stimulus [GO:0071260]; immune response [GO:0006955]; myeloid dendritic cell differentiation [GO:0043011]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of JNK cascade [GO:0046330]; signal transduction [GO:0007165]; tumor necrosis factor-mediated signaling pathway [GO:0033209]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P36941-1; Sequence=Displayed; Name=2; IsoId=P36941-2; Sequence=VSP_047533; Note=No experimental confirmation available.; 


uniprotID: Q6P5X7
geneSymbol: TMEM71
name: Transmembrane protein 71
length: 295
go: ENSG00000165071;
opentargets: integral component of membrane [GO:0016021]; mitochondrion [GO:0005739]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6P5X7-1; Sequence=Displayed; Note=No experimental confirmation available. Gene prediction based on similarity to the mouse ortholog. {ECO:0000305}; Name=2; IsoId=Q6P5X7-2; Sequence=VSP_023259; Name=3; IsoId=Q6P5X7-3; Sequence=VSP_023260; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q9BX73
geneSymbol: TM2D2
name: TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1)
length: 214
go: ENSG00000169490;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BX73-1; Sequence=Displayed; Name=2; IsoId=Q9BX73-2; Sequence=VSP_027495; 


uniprotID: Q5T7P6
geneSymbol: TMEM78
name: Transmembrane protein 78
length: 136
go: ENSG00000177800;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MWLDTRNLGIVISCWKGVCVPQTTTLEMFYNDNDRVEESSNSYQIRREFLLPACLPAFLSFSTSFSFFLSFLPLSLSLFLPFFPSFFLSLSLSPSFLPSFLRQGLALSPRLECDGAIMIHCSLNIPGSSDPPTSAS


uniprotID: P12270
geneSymbol: TPR
pdb: 5TO5;5TO6;5TO7;5TVB;
length: 2363
go: ENSG00000047410;
snps: rs3753565 rs35550453 rs35766045
reactome:
R-HSA-1169408;R-HSA-159227;R-HSA-159230;R-HSA-159231;R-HSA-159236;R-HSA-165054;R-HSA-168271;R-HSA-168276;R-HSA-168325;R-HSA-168333;R-HSA-170822;R-HSA-180746;R-HSA-180910;R-HSA-191859;R-HSA-3108214;R-HSA-3232142;R-HSA-3301854;R-HSA-3371453;R-HSA-4085377;R-HSA-4551638;R-HSA-4570464;R-HSA-4615885;R-HSA-5578749;R-HSA-5619107;R-HSA-6784531;

name:
Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic dynein complex [GO:0005868]; extrinsic component of membrane [GO:0019898]; kinetochore [GO:0000776]; mitotic spindle [GO:0072686]; nuclear envelope [GO:0005635]; nuclear inclusion body [GO:0042405]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear pore [GO:0005643]; nuclear pore nuclear basket [GO:0044615]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; chromatin binding [GO:0003682]; dynein complex binding [GO:0070840]; heat shock protein binding [GO:0031072]; mitogen-activated protein kinase binding [GO:0051019]; mRNA binding [GO:0003729]; protein homodimerization activity [GO:0042803]; RNA binding [GO:0003723]; structural constituent of nuclear pore [GO:0017056]; tubulin binding [GO:0015631]; cell division [GO:0051301]; cellular response to heat [GO:0034605]; cellular response to interferon-alpha [GO:0035457]; mitotic spindle assembly checkpoint [GO:0007094]; mRNA export from nucleus [GO:0006406]; mRNA export from nucleus in response to heat stress [GO:0031990]; negative regulation of RNA export from nucleus [GO:0046832]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of translational initiation [GO:0045947]; nuclear pore organization [GO:0006999]; positive regulation of heterochromatin assembly [GO:0031453]; positive regulation of intracellular protein transport [GO:0090316]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of protein import into nucleus [GO:0042307]; protein import into nucleus [GO:0006606]; regulation of mitotic sister chromatid separation [GO:0010965]; regulation of mitotic spindle assembly [GO:1901673]; regulation of protein localization [GO:0032880]; response to epidermal growth factor [GO:0070849]; RNA export from nucleus [GO:0006405]; RNA import into nucleus [GO:0006404]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P12270-1; Sequence=Displayed; Name=2; IsoId=P12270-2; Sequence=VSP_057406, VSP_057407; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}; Peripheral membrane protein {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}; Nucleoplasmic side {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}. Nucleus envelope {ECO:0000269|PubMed:12424524, ECO:0000269|PubMed:7798308}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:11514627, ECO:0000269|PubMed:11839768, ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:7798308, ECO:0000269|PubMed:9024684, ECO:0000269|PubMed:9828100, ECO:0000269|PubMed:9864356}. Cytoplasm {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:12802065}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:19273613}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18981471}. Nucleus membrane {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:7798308}; Peripheral membrane protein {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:7798308}; Cytoplasmic side {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:7798308}. Note=Detected as discrete intranuclear foci with IFI204 (By similarity). In interphase, localizes to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Detected exclusively to the cytoplasmic margin of NPC (PubMed:7798308). Docking to the inner nucleoplasmic side of the NPC is mediated through binding to nucleoporins. Anchored by NUP153 to the NPC. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected as filaments that emanate from the nuclear basket of the NPC and extend to the nucleolus to delineate a chromatin-free network extending from the nuclear envelope to the perinucleolar region. Detected in diffuse and discrete spheroidal intranuclear foci. Nucleocytoplasmic shuttling protein imported into the nucleus in a XPO1/CRM1- and Importin alpha/Importin beta receptor-dependent manner. Remains localized to the nuclear membrane after poliovirus (PV) infection. During mitosis, remains associated with the nuclear envelope until prometaphase. Associated with the mitotic spindle from late prometaphase until anaphase. Reorganized during mitosis in a viscous and dynamic nuclear-derived spindle matrix that embeds the microtubule spindle apparatus from pole to pole in a microtubule-independent manner. Recruited to the reforming nuclear envelope during telophase and cytokinesis. Detected at kinetochores during prometaphase (PubMed:18981471). Colocalizes with MAD2L1 in the spindle matrix but not at kinetochore (PubMed:19273613). Colocalizes with dynein, dynactin, tubulin at kinetochore during the metaphase-anaphase transition. Colocalizes with DYNLL1 at the mitotic spindle. {ECO:0000250, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:7798308}.


uniprotID: Q96PN8
geneSymbol: TSSK3
length: 268
go: ENSG00000162526;
snps: rs35508255 rs55786268 rs35457991
name:
Testis-specific serine/threonine-protein kinase 3 (TSK-3) (TSSK-3) (Testis-specific kinase 3) (EC 2.7.11.1) (Serine/threonine-protein kinase 22C)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; cell differentiation [GO:0030154]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; protein phosphorylation [GO:0006468]; spermatogenesis [GO:0007283]


uniprotID: P53804
geneSymbol: TTC3
length: 2025
go: ENSG00000182670;
snps: rs1053808 rs1053840 rs1053966
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20059950}.
name:
E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)

sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein K48-linked ubiquitination [GO:0070936]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=TPRDI; IsoId=P53804-1; Sequence=Displayed; Name=TPRDII; IsoId=P53804-2; Sequence=VSP_006554; Name=TPRDIII; IsoId=P53804-3; Sequence=VSP_006555; 


uniprotID: Q9BXA6
geneSymbol: TSSK6
length: 273
go: ENSG00000178093;
name:
Testis-specific serine/threonine-protein kinase 6 (TSK-6) (TSSK-6) (Testis-specific kinase 6) (EC 2.7.11.1) (Cancer/testis antigen 72) (CT72) (Serine/threonine-protein kinase SSTK) (Small serine/threonine kinase)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; ATP binding [GO:0005524]; magnesium ion binding [GO:0000287]; protein serine/threonine kinase activity [GO:0004674]; protein-containing complex binding [GO:0044877]; intracellular signal transduction [GO:0035556]; multicellular organism development [GO:0007275]; peptidyl-serine phosphorylation [GO:0018105]; protein phosphorylation [GO:0006468]; sperm chromatin condensation [GO:0035092]


uniprotID: Q9NQE7
geneSymbol: PRSS16
name: Thymus-specific serine protease (EC 3.4.-.-) (Serine protease 16)
length: 514
go: ENSG00000112812;
snps: rs5030965 rs35466700
location: SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal.
sequence:

opentargets:
endosome [GO:0005768]; lysosome [GO:0005764]; dipeptidyl-peptidase activity [GO:0008239]; serine-type peptidase activity [GO:0008236]; protein catabolic process [GO:0030163]; proteolysis [GO:0006508]


uniprotID: Q8N584
geneSymbol: TTC39C
name: Tetratricopeptide repeat protein 39C (TPR repeat protein 39C)
length: 583
go: ENSG00000168234;
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N584-1; Sequence=Displayed; Name=2; IsoId=Q8N584-2; Sequence=VSP_022720; Name=3; IsoId=Q8N584-3; Sequence=VSP_046039, VSP_046040; Note=No experimental confirmation available.; 


uniprotID: B1AH88
geneSymbol: TSPO
name: Putative peripheral benzodiazepine receptor-related protein
length: 102
snps: rs6971
sequence:
MAPHLLWCPTNGLGLGGSPAGQWGGGSHYRGLVPGEPAGRPPALPLPGLAGLHDHTQLLRMAGQPWLAWGTAAARVSARPTRDCSCTSRCHHACDVVAVTLS

opentargets:
mitochondrial outer membrane [GO:0005741]; androgen binding [GO:0005497]; benzodiazepine receptor activity [GO:0008503]; ion channel binding [GO:0044325]; adrenal gland development [GO:0030325]; aging [GO:0007568]; behavioral response to pain [GO:0048266]; cellular hypotonic response [GO:0071476]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to zinc ion [GO:0071294]; chloride transport [GO:0006821]; contact inhibition [GO:0060242]; establishment of protein localization to mitochondrion [GO:0072655]; glial cell migration [GO:0008347]; maintenance of protein location in mitochondrion [GO:0072656]; negative regulation of ATP metabolic process [GO:1903579]; negative regulation of autophagy of mitochondrion [GO:1903147]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of protein ubiquitination [GO:0031397]; negative regulation of tumor necrosis factor production [GO:0032720]; peripheral nervous system axon regeneration [GO:0014012]; positive regulation of apoptotic process [GO:0043065]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of glial cell proliferation [GO:0060252]; positive regulation of mitochondrial depolarization [GO:0051901]; positive regulation of necrotic cell death [GO:0010940]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; regulation of steroid biosynthetic process [GO:0050810]; response to manganese ion [GO:0010042]; response to progesterone [GO:0032570]; response to testosterone [GO:0033574]; response to vitamin B1 [GO:0010266]; steroid biosynthetic process [GO:0006694]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; Synonyms=PBR-S; IsoId=B1AH88-1; Sequence=Displayed; Note=No experimental confirmation available. The relatively low levels of the corresponding mRNA suggest that it might represent errors of the splicing machinery. In addition, isoform 2 is derived from a different reading frame, compared to isoform 1 and lacks homolog support.; Name=1; IsoId=P30536-1; Sequence=External; 


uniprotID: Q86VY4
geneSymbol: TSPYL5
name: Testis-specific Y-encoded-like protein 5 (TSPY-like protein 5)
length: 417
go: ENSG00000180543;
snps: rs2635164 rs17854366
sequence:

opentargets:
nucleus [GO:0005634]; cellular response to gamma radiation [GO:0071480]; nucleosome assembly [GO:0006334]; positive regulation of cell proliferation [GO:0008284]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of protein ubiquitination [GO:0031398]; regulation of growth [GO:0040008]


uniprotID: Q53H54
geneSymbol: TRMT12
reactome: R-HSA-6782861;
length: 448
go: ENSG00000183665;
snps: rs3812475
name:
tRNA wybutosine-synthesizing protein 2 homolog (tRNA-yW-synthesizing protein 2) (EC 2.5.1.114) (tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase)

sequence:

opentargets:
cytoplasm [GO:0005737]; tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity [GO:0102522]; tRNA methyltransferase activity [GO:0008175]; tRNA methylation [GO:0030488]; wybutosine biosynthetic process [GO:0031591]


uniprotID: Q8IWF7
geneSymbol: UBE2DNL
sequence: MALKLIHKEFLELARDPQPHCSAGPVWDDMLHWQATITRPNDSSYLGGVFFLKFPSDYLFKPPKIKFTNGIYHQR
length: 75
name:
Putative ubiquitin-conjugating enzyme E2 D2-like protein (Ubiquitin carrier protein D2-like) (Ubiquitin-conjugating enzyme E2D N-terminal-like) (Ubiquitin-protein ligase D2-like)


uniprotID: Q15029
geneSymbol: EFTUD2
reactome: R-HSA-72163;R-HSA-72165;
pdb: 3JCR;5MQF;5O9Z;5XJC;5YZG;5Z56;5Z57;5Z58;6FF4;
length: 972
go: ENSG00000108883;
snps: rs387906877 rs387906879 rs1056505
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735}.
name:
116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa)

sequence:

opentargets:
Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; cytosol [GO:0005829]; membrane [GO:0016020]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; spliceosomal complex [GO:0005681]; U2-type catalytic step 2 spliceosome [GO:0071007]; U4/U6 x U5 tri-snRNP complex [GO:0046540]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; RNA binding [GO:0003723]; cellular response to drug [GO:0035690]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; response to cocaine [GO:0042220]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q15029-1; Sequence=Displayed; Name=2; IsoId=Q15029-2; Sequence=VSP_044282; Name=3; IsoId=Q15029-3; Sequence=VSP_055175; Note=No experimental confirmation available.; 


uniprotID: D6RBQ6
geneSymbol: USP17L17
reactome: R-HSA-5689880;
name: Ubiquitin carboxyl-terminal hydrolase 17-like protein 17 (EC 3.4.19.12)
length: 530
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
sequence:


uniprotID: Q0WX57
geneSymbol: USP17L24; USP17L25; USP17L26; USP17L27; USP17L28; USP17L29; USP17L30
reactome: R-HSA-5689880;
length: 530
go: ENSG00000228856;
name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC 3.4.19.12) (Deubiquitinating enzyme 17) (Ubiquitin thioesterase 17) (Ubiquitin-specific-processing protease 17)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; nucleolus [GO:0005730]; nucleus [GO:0005634]; cysteine-type endopeptidase activity [GO:0004197]; hyaluronic acid binding [GO:0005540]; RNA binding [GO:0003723]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; apoptotic process [GO:0006915]; positive regulation of epithelial cell apoptotic process [GO:1904037]; protein deubiquitination [GO:0016579]; protein deubiquitination involved in ubiquitin-dependent protein catabolic process [GO:0071947]; regulation of apoptotic process [GO:0042981]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17109758}. Endoplasmic reticulum {ECO:0000250}.


uniprotID: P49427
geneSymbol: CDC34
reactome: R-HSA-202424;R-HSA-2871837;R-HSA-5607764;R-HSA-8866652;R-HSA-983168;
pdb: 2OB4;3RZ3;4MDK;
length: 236
go: ENSG00000099804;
snps: rs16990650
name:
Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; cellular protein modification process [GO:0006464]; cellular response to interferon-beta [GO:0035458]; DNA replication initiation [GO:0006270]; G1/S transition of mitotic cell cycle [GO:0000082]; negative regulation of cAMP-mediated signaling [GO:0043951]; positive regulation of inclusion body assembly [GO:0090261]; positive regulation of neuron apoptotic process [GO:0043525]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein K48-linked ubiquitination [GO:0070936]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to growth factor [GO:0070848]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase.


uniprotID: Q13404
geneSymbol: UBE2V1
pdb: 2A4D;2C2V;2HLW;
length: 147
go: ENSG00000244687;
reactome:
R-HSA-168638;R-HSA-168927;R-HSA-202424;R-HSA-2871837;R-HSA-445989;R-HSA-450302;R-HSA-450321;R-HSA-5607764;R-HSA-9020702;R-HSA-937039;R-HSA-937041;R-HSA-975110;R-HSA-975144;R-HSA-983168;

name:
Ubiquitin-conjugating enzyme E2 variant 1 (UEV-1) (CROC-1) (TRAF6-regulated IKK activator 1 beta Uev1A)

sequence:
MAATTGSGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTIYENRIYSLKIECGPKYPEAPPFVRFVTKINMNGVNSSNGVVDPRAISVLAKWQNSYSIKVVLQELRRLMMSKENMKLPQPPEGQCYSN

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; UBC13-UEV1A complex [GO:0035370]; ubiquitin conjugating enzyme complex [GO:0031371]; ubiquitin ligase complex [GO:0000151]; ubiquitin conjugating enzyme activity [GO:0061631]; activation of MAPK activity [GO:0000187]; cell differentiation [GO:0030154]; interleukin-1-mediated signaling pathway [GO:0070498]; JNK cascade [GO:0007254]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription, DNA-templated [GO:0045893]; postreplication repair [GO:0006301]; protein K63-linked ubiquitination [GO:0070534]; protein polyubiquitination [GO:0000209]; regulation of DNA repair [GO:0006282]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist.; Name=3; Synonyms=Isoform 2; IsoId=Q13404-4; Sequence=Displayed; Name=1; Synonyms=CROC-1B, UEV-1B, Isoform 4; IsoId=Q13404-1; Sequence=VSP_038034; Name=2; Synonyms=CROC-1A, UEV-1A; IsoId=Q13404-2; Sequence=VSP_038033; Name=4; Synonyms=UEV-1As; IsoId=Q13404-6; Sequence=VSP_038032, VSP_038036; Name=5; Synonyms=Isoform 3; IsoId=Q13404-7; Sequence=VSP_038035; Name=6; IsoId=Q13404-8; Sequence=VSP_044818; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:9305758}. Note=Excluded from the nucleolus.


uniprotID: P0CG47
geneSymbol: UBB
name: Polyubiquitin-B [Cleaved into: Ubiquitin]
length: 229
go: ENSG00000170315;
drug: DB02542;
location: SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
reactome:
R-HSA-110312;R-HSA-110314;R-HSA-110320;R-HSA-1169091;R-HSA-1169408;R-HSA-1234176;R-HSA-1236382;R-HSA-1236974;R-HSA-1253288;R-HSA-1295596;R-HSA-1358803;R-HSA-162588;R-HSA-168638;R-HSA-168927;R-HSA-168928;R-HSA-174048;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-174490;R-HSA-175474;R-HSA-179409;R-HSA-180534;R-HSA-180585;R-HSA-182971;R-HSA-187577;R-HSA-195253;R-HSA-201681;R-HSA-202424;R-HSA-205043;R-HSA-209543;R-HSA-209560;R-HSA-211733;R-HSA-2122947;R-HSA-2122948;R-HSA-2173788;R-HSA-2173791;R-HSA-2173795;R-HSA-2173796;R-HSA-2467813;R-HSA-2559580;R-HSA-2559582;R-HSA-2559585;R-HSA-2565942;R-HSA-2644606;R-HSA-2672351;R-HSA-2691232;R-HSA-2871837;R-HSA-2894862;R-HSA-2979096;R-HSA-3134975;R-HSA-3322077;R-HSA-349425;R-HSA-3769402;R-HSA-3785653;R-HSA-382556;R-HSA-400253;R-HSA-445989;R-HSA-450302;R-HSA-450321;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-4641263;R-HSA-5205685;R-HSA-532668;R-HSA-5357905;R-HSA-5357956;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5654726;R-HSA-5654727;R-HSA-5654732;R-HSA-5654733;R-HSA-5655862;R-HSA-5656121;R-HSA-5656169;R-HSA-5658442;R-HSA-5668541;R-HSA-5675221;R-HSA-5675482;R-HSA-5676590;R-HSA-5678895;R-HSA-5684264;R-HSA-5685942;R-HSA-5687128;R-HSA-5689603;R-HSA-5689877;R-HSA-5689880;R-HSA-5689896;R-HSA-5689901;R-HSA-5693565;R-HSA-5693607;R-HSA-5696394;R-HSA-5696395;R-HSA-5696397;R-HSA-5696400;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6783310;R-HSA-6804756;R-HSA-6804757;R-HSA-6804760;R-HSA-6807004;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69231;R-HSA-69481;R-HSA-69541;R-HSA-69601;R-HSA-8849469;R-HSA-8852276;R-HSA-8854050;R-HSA-8856825;R-HSA-8856828;R-HSA-8863795;R-HSA-8866652;R-HSA-8866654;R-HSA-8875360;R-HSA-8876493;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948747;R-HSA-8948751;R-HSA-8951664;R-HSA-901032;R-HSA-9010553;R-HSA-9013507;R-HSA-9013973;R-HSA-9014325;R-HSA-9020702;R-HSA-9033241;R-HSA-912631;R-HSA-917729;R-HSA-917937;R-HSA-936440;R-HSA-936964;R-HSA-937039;R-HSA-937041;R-HSA-937042;R-HSA-937072;R-HSA-9604323;R-HSA-975110;R-HSA-975144;R-HSA-975163;R-HSA-977225;R-HSA-983168;

pdb:
2KHW;2MBB;2MRO;2MSG;2N13;4UEL;4UF6;4WHV;4WLR;4WUR;4XOF;4ZFR;4ZFT;4ZPZ;4ZUX;5BNB;5CAW;5CRA;5CVM;5CVN;5CVO;5D0K;5D0M;5DFL;5DK8;5E6J;5EDV;5EMZ;5EYA;5GJQ;5GO7;5GO8;5GOB;5GOC;5GOD;5GOG;5GOH;5GOI;5GOJ;5GOK;5H7S;5IBK;5IFR;5JBY;5JG6;5JP3;5JTJ;5JTV;5K9P;5KGF;5KHY;5KYC;5KYD;5KYE;5KYF;5L8H;5L8W;5L9T;5LN1;5LRV;5LRW;5LRX;5M93;5MNJ;5N2W;5N38;5NL5;5NLJ;5NVG;5O44;5O6T;5OHK;5OHL;5OHN;5OHP;5TOF;5TOG;5TUT;5UCL;5UJL;5UJN;5ULF;5ULH;5ULK;5V1Y;5V1Z;5VEY;5VF0;5VNZ;5VO0;5VZM;5VZW;5W46;5WFI;5X3M;5X3N;5X3O;5XBO;5XDP;5XK4;5XK5;5XPK;5YDR;5YIJ;5YIK;5YT6;6ASR;6BVA;6BYH;6C16;6CP2;6EI1;6FDK;6FGE;6FTX;6GLC;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; host cell [GO:0043657]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; protein tag [GO:0031386]; ubiquitin protein ligase binding [GO:0031625]; activation of MAPK activity [GO:0000187]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular protein metabolic process [GO:0044267]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, detection of DNA damage [GO:0042769]; endosomal transport [GO:0016197]; energy homeostasis [GO:0097009]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; fat pad development [GO:0060613]; female gonad development [GO:0008585]; female meiosis I [GO:0007144]; global genome nucleotide-excision repair [GO:0070911]; hypothalamus gonadotrophin-releasing hormone neuron development [GO:0021888]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; interleukin-1-mediated signaling pathway [GO:0070498]; interstrand cross-link repair [GO:0036297]; intracellular transport of virus [GO:0075733]; JNK cascade [GO:0007254]; male meiosis I [GO:0007141]; membrane organization [GO:0061024]; mitochondrion transport along microtubule [GO:0047497]; modification-dependent protein catabolic process [GO:0019941]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; neuron projection morphogenesis [GO:0048812]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; positive regulation of apoptotic process [GO:0043065]; positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator [GO:1902255]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein monoubiquitination [GO:1902527]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; protein polyubiquitination [GO:0000209]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]; regulation of mitochondrial membrane potential [GO:0051881]; regulation of mRNA stability [GO:0043488]; regulation of neuron death [GO:1901214]; regulation of proteasomal protein catabolic process [GO:0061136]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; seminiferous tubule development [GO:0072520]; stress-activated MAPK cascade [GO:0051403]; transcription-coupled nucleotide-excision repair [GO:0006283]; transforming growth factor beta receptor signaling pathway [GO:0007179]; translesion synthesis [GO:0019985]; transmembrane transport [GO:0055085]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; viral life cycle [GO:0019058]; virion assembly [GO:0019068]; Wnt signaling pathway [GO:0016055]


uniprotID: Q8N2K1
geneSymbol: UBE2J2
reactome: R-HSA-8866654;R-HSA-983168;
pdb: 2F4W;
length: 259
name:
Ubiquitin-conjugating enzyme E2 J2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J2) (Non-canonical ubiquitin-conjugating enzyme 2) (NCUBE-2)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; ubiquitin ligase complex [GO:0000151]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; positive regulation of protein targeting to mitochondrion [GO:1903955]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; response to unfolded protein [GO:0006986]; ubiquitin-dependent ERAD pathway [GO:0030433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N2K1-1; Sequence=Displayed; Name=2; IsoId=Q8N2K1-2; Sequence=VSP_011572; Note=No experimental confirmation available.; Name=3; IsoId=Q8N2K1-3; Sequence=VSP_045219; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y385}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9Y385}.


uniprotID: Q16763
geneSymbol: UBE2S
reactome: R-HSA-8866652;R-HSA-983168;
pdb: 1ZDN;5BNB;5L9T;
length: 222
go: ENSG00000108106;
name:
Ubiquitin-conjugating enzyme E2 S (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme S) (E2-EPF) (Ubiquitin carrier protein S) (Ubiquitin-conjugating enzyme E2-24 kDa) (Ubiquitin-conjugating enzyme E2-EPF5) (Ubiquitin-protein ligase S)

sequence:

opentargets:
anaphase-promoting complex [GO:0005680]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; anaphase-promoting complex binding [GO:0010997]; ATP binding [GO:0005524]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin-protein transferase activity [GO:0004842]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cell division [GO:0051301]; cellular protein modification process [GO:0006464]; exit from mitosis [GO:0010458]; free ubiquitin chain polymerization [GO:0010994]; positive regulation of ubiquitin protein ligase activity [GO:1904668]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q9NPD8
geneSymbol: UBE2T
reactome: R-HSA-6783310;R-HSA-8866652;
pdb: 1YH2;4CCG;5NGZ;5OJJ;
length: 197
go: ENSG00000077152;
snps: rs774357609
name:
Ubiquitin-conjugating enzyme E2 T (EC 2.3.2.23) (Cell proliferation-inducing gene 50 protein) (E2 ubiquitin-conjugating enzyme T) (Ubiquitin carrier protein T) (Ubiquitin-protein ligase T)

sequence:
MQRASRLKRELHMLATEPPPGITCWQDKDQMDDLRAQILGGANTPYEKGVFKLEVIIPERYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKLPPKGAWRPSLNIATVLTSIQLLMSEPNPDDPLMADISSEFKYNKPAFLKNARQWTEKHARQKQKADEEEMLDNLPEAGDSRVHNSTQKRKASQLVGIEKKFHPDV

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; chromatin binding [GO:0003682]; ubiquitin conjugating enzyme activity [GO:0061631]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; interstrand cross-link repair [GO:0036297]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K27-linked ubiquitination [GO:0044314]; protein K29-linked ubiquitination [GO:0035519]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17938197, ECO:0000269|PubMed:19887602}. Note=Accumulates to chromatin.


uniprotID: P0CB48
geneSymbol: UBTFL6
name: Putative upstream-binding factor 1-like protein 6
length: 400
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
sequence:


uniprotID: Q9UHP3
geneSymbol: USP25
reactome: R-HSA-5689880;
pdb: 2MUX;5GP7;5O71;
length: 1055
go: ENSG00000155313;
name:
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; ATPase binding [GO:0051117]; cysteine-type endopeptidase activity [GO:0004197]; peptidase activity [GO:0008233]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-specific protease activity involved in negative regulation of ERAD pathway [GO:1904455]; cellular protein modification process [GO:0006464]; negative regulation of ERAD pathway [GO:1904293]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; proteolysis [GO:0006508]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=USP25a; IsoId=Q9UHP3-2; Sequence=Displayed; Name=USP25b; IsoId=Q9UHP3-1; Sequence=VSP_039632; Name=USP25m; Synonyms=Muscle-specific isoform; IsoId=Q9UHP3-3; Sequence=VSP_039631; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16501887, ECO:0000269|PubMed:19440361}.; SUBCELLULAR LOCATION: Isoform USP25m: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Some transient punctuate nuclear location in myotubes during myocyte development. {ECO:0000250}.


uniprotID: Q13107
geneSymbol: USP4
reactome: R-HSA-5357786;R-HSA-5357905;R-HSA-5357956;R-HSA-5689880;
pdb: 2Y6E;5CTR;
length: 963
go: ENSG00000114316;
snps: rs9311440
name:
Ubiquitin carboxyl-terminal hydrolase 4 (EC 3.4.19.12) (Deubiquitinating enzyme 4) (Ubiquitin thioesterase 4) (Ubiquitin-specific-processing protease 4) (Ubiquitous nuclear protein homolog)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; lysosome [GO:0005764]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; adenosine receptor binding [GO:0031685]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; negative regulation of protein ubiquitination [GO:0031397]; protein deubiquitination [GO:0016579]; protein localization to cell surface [GO:0034394]; regulation of protein stability [GO:0031647]; spliceosomal tri-snRNP complex assembly [GO:0000244]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=UnpEL; IsoId=Q13107-1; Sequence=Displayed; Name=2; Synonyms=UnpES; IsoId=Q13107-2; Sequence=VSP_005258; Name=3; IsoId=Q13107-3; Sequence=VSP_044814, VSP_044815; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Nucleus {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}. Note=Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucleus and cytoplasm vary according to the cell type. {ECO:0000269|PubMed:16316627, ECO:0000269|PubMed:20595234}.


uniprotID: Q70EL2
geneSymbol: USP45
reactome: R-HSA-5696395;
length: 814
go: ENSG00000123552;
snps: rs7744845 rs41288947 rs6570065
name:
Ubiquitin carboxyl-terminal hydrolase 45 (EC 3.4.19.12) (Deubiquitinating enzyme 45) (Ubiquitin thioesterase 45) (Ubiquitin-specific-processing protease 45)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; zinc ion binding [GO:0008270]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; protein deubiquitination [GO:0016579]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q70EL2-1; Sequence=Displayed; Name=2; IsoId=Q70EL2-2; Sequence=VSP_023791, VSP_023792; Note=No experimental confirmation available.; Name=3; IsoId=Q70EL2-3; Sequence=VSP_023789, VSP_023790, VSP_023793; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; 


uniprotID: Q8N806
geneSymbol: UBR7
length: 425
go: ENSG00000012963;
name:
Putative E3 ubiquitin-protein ligase UBR7 (EC 2.3.2.27) (N-recognin-7) (RING-type E3 ubiquitin transferase UBR7)

sequence:

opentargets:
transferase activity [GO:0016740]; zinc ion binding [GO:0008270]; protein ubiquitination [GO:0016567]


uniprotID: Q70EL3
geneSymbol: USP50
name: Inactive ubiquitin carboxyl-terminal hydrolase 50 (Inactive ubiquitin-specific peptidase 50)
length: 339
go: ENSG00000170236;
sequence:

opentargets:
cytosol [GO:0005829]; dendritic spine [GO:0043197]; extrinsic component of endosome membrane [GO:0031313]; extrinsic component of plasma membrane [GO:0019897]; midbody [GO:0030496]; postsynaptic density [GO:0014069]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; ubiquitin-like protein-specific protease activity [GO:0019783]; endosome organization [GO:0007032]; positive regulation of cysteine-type endopeptidase activity [GO:2001056]; positive regulation of interleukin-1 beta secretion [GO:0050718]; positive regulation of interleukin-18 production [GO:0032741]; positive regulation of NLRP3 inflammasome complex assembly [GO:1900227]; positive regulation of protein homooligomerization [GO:0032464]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; protein K63-linked deubiquitination [GO:0070536]; Ras protein signal transduction [GO:0007265]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q70EL3-1; Sequence=Displayed; Name=2; IsoId=Q70EL3-2; Sequence=VSP_054248; 


uniprotID: Q9UMX0
geneSymbol: UBQLN1
reactome: R-HSA-8856825;
pdb: 2JY5;2JY6;2KLC;
name: Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
length: 589
go: ENSG00000135018;
sequence:

opentargets:
aggresome [GO:0016235]; autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; proteasome complex [GO:0000502]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; kinase binding [GO:0019900]; polyubiquitin modification-dependent protein binding [GO:0031593]; aggrephagy [GO:0035973]; autophagosome assembly [GO:0000045]; autophagosome maturation [GO:0097352]; cellular response to hypoxia [GO:0071456]; macroautophagy [GO:0016236]; negative regulation of store-operated calcium channel activity [GO:1901340]; negative regulation of toll-like receptor 3 signaling pathway [GO:0034140]; positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071]; positive regulation of protein ubiquitination [GO:0031398]; regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [GO:1902175]; regulation of protein ubiquitination [GO:0031396]; response to endoplasmic reticulum stress [GO:0034976]; ubiquitin-dependent ERAD pathway [GO:0030433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9UMX0-1; Sequence=Displayed; Name=2; IsoId=Q9UMX0-2; Sequence=VSP_009787; Note=No experimental confirmation available.; Name=3; IsoId=Q9UMX0-3; Sequence=VSP_057689; Name=4; IsoId=Q9UMX0-4; Sequence=VSP_057690, VSP_057691; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16159959, ECO:0000269|PubMed:23979357}. Nucleus {ECO:0000269|PubMed:23979357}. Endoplasmic reticulum {ECO:0000269|PubMed:19822669}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19148225, ECO:0000269|PubMed:20529957, ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:23307288, ECO:0000269|PubMed:23459205}. Cell membrane {ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:23307288}. Note=Detected in neuronal processes and at synapses (By similarity). Recruited to the ER during ER-associated protein degradation (ERAD) (PubMed:19822669). Isoform 1 and isoform 3 colocalize with PSEN1 in the cell membrane and in cytoplasmic juxtanuclear structures called aggresomes (PubMed:21143716). Colocalizes with ORAI1 and TICAM1 in the autophagosome (PubMed:23307288, PubMed:21695056). Colocalizes with EPS15 and HGS in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and with EPS15 also in aggresomes (PubMed:16159959). {ECO:0000250|UniProtKB:Q9JJP9, ECO:0000269|PubMed:16159959, ECO:0000269|PubMed:19822669, ECO:0000269|PubMed:21143716, ECO:0000269|PubMed:21695056, ECO:0000269|PubMed:23307288}.


uniprotID: P45974
geneSymbol: USP5
reactome: R-HSA-5689880;R-HSA-8866652;
pdb: 2DAG;2DAK;2G43;2G45;3IHP;6DXH;6DXT;
length: 858
go: ENSG00000111667;
name:
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)

sequence:

opentargets:
cytosol [GO:0005829]; lysosome [GO:0005764]; cysteine-type endopeptidase activity [GO:0004197]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; ubiquitin binding [GO:0043130]; zinc ion binding [GO:0008270]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; protein deubiquitination [GO:0016579]; protein K48-linked deubiquitination [GO:0071108]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=P45974-1; Sequence=Displayed; Name=Short; IsoId=P45974-2; Sequence=VSP_005259; 


uniprotID: P35125
geneSymbol: USP6
length: 1406
go: ENSG00000129204;
snps: rs8073787 rs2304449 rs9899177
name:
Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)

sequence:

opentargets:
cytoplasm [GO:0005737]; lysosome [GO:0005764]; plasma membrane [GO:0005886]; recycling endosome [GO:0055037]; calmodulin binding [GO:0005516]; cysteine-type endopeptidase activity [GO:0004197]; GTPase activator activity [GO:0005096]; nucleic acid binding [GO:0003676]; Rab GTPase binding [GO:0017137]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; activation of GTPase activity [GO:0090630]; cellular protein modification process [GO:0006464]; intracellular protein transport [GO:0006886]; protein deubiquitination [GO:0016579]; regulation of vesicle-mediated transport [GO:0060627]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P35125-1; Sequence=Displayed; Name=2; Synonyms=213(ORF2); IsoId=P35125-2; Sequence=VSP_010878, VSP_010879; Name=3; Synonyms=210(ORF1), oncTre210p; IsoId=P35125-3; Sequence=VSP_010880, VSP_010881; Note=Was shown to be tumorigenic in transfected mice and seems not to act as GTPase activating protein.; 

location:
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.


uniprotID: Q14CS0
geneSymbol: UBXN2B
name: UBX domain-containing protein 2B (NSFL1 cofactor p37) (p97 cofactor p37)
length: 331
go: ENSG00000215114;
sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; nucleus [GO:0005634]; spindle pole centrosome [GO:0031616]; ubiquitin binding [GO:0043130]; autophagosome assembly [GO:0000045]; establishment of mitotic spindle orientation [GO:0000132]; Golgi organization [GO:0007030]; membrane fusion [GO:0061025]; negative regulation of protein localization to centrosome [GO:1904780]; nuclear envelope reassembly [GO:0031468]; positive regulation of mitotic centrosome separation [GO:0046604]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C627}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P0C627}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P0C627}. Golgi apparatus {ECO:0000250|UniProtKB:P0C627}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q0KL01}. Note=Localizes to centrosome during mitotic prophase and metaphase. {ECO:0000250|UniProtKB:Q0KL01}.


uniprotID: Q96RP3
geneSymbol: UCN2
reactome: R-HSA-373080;
pdb: 2RMG;3N95;
name: Urocortin-2 (Stresscopin-related peptide) (Urocortin II) (Ucn II) (Urocortin-related peptide)
length: 112
go: ENSG00000145040;
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MTRCALLLLMVLMLGRVLVVPVTPIPTFQLRPQNSPQTTPRPAASESPSAAPTWPWAAQSHCSPTRHPGSRIVLSLDVPIGLLQILLEQARARAAREQATTNARILARVGHC

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; corticotropin-releasing hormone receptor 2 binding [GO:0051431]; corticotropin-releasing hormone receptor binding [GO:0051429]; G protein-coupled receptor binding [GO:0001664]; hormone activity [GO:0005179]; hormone binding [GO:0042562]; adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cellular response to nutrient levels [GO:0031669]; digestion [GO:0007586]; hormone-mediated signaling pathway [GO:0009755]


uniprotID: P35504
geneSymbol: UGT1A5
reactome: R-HSA-156588;
length: 534
go: ENSG00000240224;
snps: rs3755323 rs3755322 rs3755321 rs3755320 rs28946885 rs12475068 rs17862867 rs17862868 rs3892170
name:
UDP-glucuronosyltransferase 1-5 (UDPGT 1-5) (UGT1*5) (UGT1-05) (UGT1.5) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-E) (UGT-1E) (UGT1E) (UDP-glucuronosyltransferase 1A5)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]; flavonoid glucuronidation [GO:0052696]; xenobiotic glucuronidation [GO:0052697]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=i1; IsoId=P35504-1; Sequence=Displayed; Name=2; Synonyms=i2, UGT1A5s; IsoId=P35504-2; Sequence=VSP_053961; 


uniprotID: Q6UWM9
geneSymbol: UGT2A3
reactome: R-HSA-156588;
name: UDP-glucuronosyltransferase 2A3 (UDPGT 2A3) (EC 2.4.1.17)
length: 527
go: ENSG00000135220;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; glucuronosyltransferase activity [GO:0015020]; UDP-glycosyltransferase activity [GO:0008194]; cellular glucuronidation [GO:0052695]


uniprotID: P22310
geneSymbol: UGT1A4
reactome: R-HSA-156588;R-HSA-189483;R-HSA-5579016;
length: 534
go: ENSG00000244474;
drug: DB06216;DB00363;DB04953;DB00555;DB00683;DB00910;DB00675;DB00831;DB00197;DB00313;
snps: rs3892221 rs6755571 rs2011425 rs45621441 rs45540231
name:
UDP-glucuronosyltransferase 1-4 (UDPGT 1-4) (UGT1*4) (UGT1-04) (UGT1.4) (EC 2.4.1.17) (Bilirubin-specific UDPGT isozyme 2) (hUG-BR2) (UDP-glucuronosyltransferase 1-D) (UGT-1D) (UGT1D) (UDP-glucuronosyltransferase 1A4)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; enzyme binding [GO:0019899]; glucuronosyltransferase activity [GO:0015020]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; UDP-glycosyltransferase activity [GO:0008194]; bilirubin conjugation [GO:0006789]; cellular glucuronidation [GO:0052695]; flavonoid glucuronidation [GO:0052696]; heme catabolic process [GO:0042167]; negative regulation of cellular glucuronidation [GO:2001030]; negative regulation of fatty acid metabolic process [GO:0045922]; negative regulation of glucuronosyltransferase activity [GO:1904224]; xenobiotic glucuronidation [GO:0052697]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=i1; IsoId=P22310-1; Sequence=Displayed; Name=2; Synonyms=i2, UGT1A4s; IsoId=P22310-2; Sequence=VSP_053960; 


uniprotID: Q92890
geneSymbol: UFD1
reactome: R-HSA-110320;R-HSA-5689880;
pdb: 2YUJ;5B6C;5C1B;
length: 307
go: ENSG00000070010;
snps: rs17744624
name:
Ubiquitin recognition factor in ER-associated degradation protein 1 (Ubiquitin fusion degradation protein 1) (UB fusion protein 1)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; UFD1-NPL4 complex [GO:0036501]; VCP-NPL4-UFD1 AAA ATPase complex [GO:0034098]; ATPase binding [GO:0051117]; K48-linked polyubiquitin modification-dependent protein binding [GO:0036435]; protein-containing complex binding [GO:0044877]; signaling receptor binding [GO:0005102]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; ER-associated misfolded protein catabolic process [GO:0071712]; error-free translesion synthesis [GO:0070987]; negative regulation of RIG-I signaling pathway [GO:0039536]; negative regulation of type I interferon production [GO:0032480]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein deubiquitination [GO:0016579]; retrograde protein transport, ER to cytosol [GO:0030970]; skeletal system development [GO:0001501]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=Short; IsoId=Q92890-2; Sequence=Displayed; Note=Major isoform.; Name=Long; IsoId=Q92890-1; Sequence=VSP_006707; Name=3; IsoId=Q92890-3; Sequence=VSP_045044; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9ES53}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES53}.


uniprotID: Q9Y3C8
geneSymbol: UFC1
pdb: 2K07;2Z6O;2Z6P;3EVX;
name: Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)
length: 167
go: ENSG00000143222;
snps: rs17849932
sequence:
MADEATRRVVSEIPVLKTNAGPRDRELWVQRLKEEYQSLIRYVENNKNADNDWFRLESNKEGTRWFGKCWYIHDLLKYEFDIEFDIPITYPTTAPEIAVPELDGKTAKMYRGGKICLTDHFKPLWARNVPKFGLAHLMALGLGPWLAVEIPDLIQKGVIQHKEKCNQ

opentargets:
extracellular exosome [GO:0070062]; UFM1 transferase activity [GO:0071568]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; response to endoplasmic reticulum stress [GO:0034976]


uniprotID: O94874
geneSymbol: UFL1
reactome: R-HSA-983168;
length: 794
go: ENSG00000014123;
snps: rs28372909
name:
E3 UFM1-protein ligase 1 (EC 2.3.2.-) (E3 UFM1-protein transferase 1) (Novel LZAP-binding protein) (Regulator of C53/LZAP and DDRGK1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; membrane [GO:0016020]; neuron projection [GO:0043005]; protein-containing complex [GO:0032991]; UFM1 transferase activity [GO:0071568]; negative regulation of apoptotic process [GO:0043066]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein ubiquitination [GO:0031397]; osteoblast differentiation [GO:0001649]; positive regulation of cell proliferation [GO:0008284]; positive regulation of glial cell proliferation [GO:0060252]; protein K69-linked ufmylation [GO:1990592]; protein ufmylation [GO:0071569]; regulation of intracellular estrogen receptor signaling pathway [GO:0033146]; regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032434]; regulation of protein localization [GO:0032880]; response to endoplasmic reticulum stress [GO:0034976]; response to L-glutamate [GO:1902065]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O94874-1; Sequence=Displayed; Name=2; IsoId=O94874-2; Sequence=VSP_038759; Note=No experimental confirmation available.; Name=3; IsoId=O94874-3; Sequence=VSP_038760, VSP_038761; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063}. Cytoplasm, cytosol {ECO:0000269|PubMed:20228063}.


uniprotID: P47985
geneSymbol: UQCRFS1
reactome: R-HSA-611105;
pdb: 5XTE;5XTH;5XTI;
length: 274
go: ENSG00000169021;
drug: DB08453;DB07778;DB07401;DB08330;DB08690;
snps: rs8100724
name:
Cytochrome b-c1 complex subunit Rieske, mitochondrial (EC 1.10.2.2) (Complex III subunit 5) (Cytochrome b-c1 complex subunit 5) (Rieske iron-sulfur protein) (RISP) (Rieske protein UQCRFS1) (Ubiquinol-cytochrome c reductase iron-sulfur subunit) [Cleaved into: Cytochrome b-c1 complex subunit 9 (Su9) (Subunit 9) (8 kDa subunit 9) (Complex III subunit IX) (Cytochrome b-c1 complex subunit 11) (Ubiquinol-cytochrome c reductase 8 kDa protein)]

sequence:

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex III [GO:0005750]; mitochondrial respiratory chain complex IV [GO:0005751]; mitochondrion [GO:0005739]; 2 iron, 2 sulfur cluster binding [GO:0051537]; metal ion binding [GO:0046872]; protein-containing complex binding [GO:0044877]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122]; response to antibiotic [GO:0046677]; response to drug [GO:0042493]; response to hormone [GO:0009725]

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q5ZLR5}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q5ZLR5}.


uniprotID: Q6ZN44
geneSymbol: UNC5A
reactome: R-HSA-373752;R-HSA-418886;R-HSA-418889;
pdb: 4V2A;
name: Netrin receptor UNC5A (Protein unc-5 homolog 1) (Protein unc-5 homolog A)
length: 842
go: ENSG00000113763;
sequence:

opentargets:
integral component of membrane [GO:0016021]; intrinsic component of plasma membrane [GO:0031226]; membrane raft [GO:0045121]; neuron projection membrane [GO:0032589]; neuronal cell body membrane [GO:0032809]; plasma membrane [GO:0005886]; netrin receptor activity [GO:0005042]; anterior/posterior axon guidance [GO:0033564]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; netrin-activated signaling pathway [GO:0038007]; neuron projection development [GO:0031175]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6ZN44-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q6ZN44-2; Sequence=VSP_011694, VSP_011695; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZN44-3; Sequence=VSP_011693; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O08721}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08721}. Membrane raft {ECO:0000250|UniProtKB:O08721}. Cell projection {ECO:0000250|UniProtKB:O08721}. Note=The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones. Detected in neurites. {ECO:0000250|UniProtKB:O08721}.


uniprotID: Q96C45
geneSymbol: ULK4
name: Serine/threonine-protein kinase ULK4 (EC 2.7.11.1) (Unc-51-like kinase 4)
length: 1275
go: ENSG00000168038;
sequence:

opentargets:
ATP binding [GO:0005524]; protein serine/threonine kinase activity [GO:0004674]; microtubule cytoskeleton organization [GO:0000226]; regulation of JNK cascade [GO:0046328]; regulation of MAPK cascade [GO:0043408]; regulation of neuron migration [GO:2001222]; regulation of neuron projection development [GO:0010975]; regulation of p38MAPK cascade [GO:1900744]; regulation of protein kinase C signaling [GO:0090036]

snps:
rs34538622 rs2272007 rs35833603 rs55840267 rs1716975 rs35263917 rs371185820 rs75907560 rs1052501 rs3774372 rs17063572 rs4973986 rs17215589 rs12488691 rs6769117 


uniprotID: Q6UXZ4
geneSymbol: UNC5D
reactome: R-HSA-418886;
name: Netrin receptor UNC5D (Protein unc-5 homolog 4) (Protein unc-5 homolog D)
length: 953
go: ENSG00000156687;
snps: rs35487923
sequence:

opentargets:
cell surface [GO:0009986]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; netrin receptor activity [GO:0005042]; apoptotic process [GO:0006915]; axon guidance [GO:0007411]; cell-cell adhesion via plasma-membrane adhesion molecules [GO:0098742]; pyramidal neuron differentiation [GO:0021859]; regulation of neuron migration [GO:2001222]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6UXZ4-1; Sequence=Displayed; Name=2; IsoId=Q6UXZ4-2; Sequence=VSP_011703; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26235030}; Single-pass type I membrane protein {ECO:0000305}.


uniprotID: P13051
geneSymbol: UNG
reactome: R-HSA-110328;R-HSA-110329;R-HSA-110357;
name: Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
length: 313
go: ENSG00000076248;
drug: DB07116;
snps: rs7488798 rs104894380
location: SUBCELLULAR LOCATION: Isoform 1: Mitochondrion.; SUBCELLULAR LOCATION: Isoform 2: Nucleus.
pdb:
1AKZ;1DPU;1EMH;1EMJ;1Q3F;1SSP;1UGH;1YUO;2HXM;2OXM;2OYT;2SSP;3FCF;3FCI;3FCK;3FCL;3TKB;4SKN;5AYR;5JK7;

sequence:

opentargets:
mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; ribosomal small subunit binding [GO:0043024]; uracil DNA N-glycosylase activity [GO:0004844]; base-excision repair [GO:0006284]; base-excision repair, AP site formation via deaminated base removal [GO:0097510]; depyrimidination [GO:0045008]; DNA repair [GO:0006281]; negative regulation of apoptotic process [GO:0043066]; positive regulation of isotype switching [GO:0045830]; somatic hypermutation of immunoglobulin genes [GO:0016446]; somatic recombination of immunoglobulin gene segments [GO:0016447]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; Synonyms=UNG2; IsoId=P13051-1; Sequence=Displayed; Name=1; Synonyms=UNG1; IsoId=P13051-2; Sequence=VSP_008513; 


uniprotID: Q6XCG6
name: Putative uncharacterized protein PP632
length: 107
sequence:
MWLSPWSTCPPHPLPSCLTACCSPAHQPVRGSAQPPASDLCTCVTCCSGPHPNYPPAHLLPTSSLPICPGLICCLLTCLLVDCFSALLSACETRDLSPWKARRVLLR


uniprotID: Q8N9X3
geneSymbol: LINC01356
name: Putative uncharacterized protein encoded by LINC01356
length: 169
sequence:
MSLRGRFYYCRHFRGRKQARRVGELPEVTELVSGPDWNPNTSQPMPGSPAPAPRRLPGCQRHPHPFKCCPVPAPQSLPSTTRPHLPPTPQGQASRWLFLFLFQKLRGETDVCVPDACRWRRRSRETRGENQSVRAAVRSPDQAFHALVSGSRGREGRLRPQCAGSAGGA


uniprotID: A8MUI8
name: Putative UPF0607 protein ENSP00000383783
length: 341
sequence:


uniprotID: Q7L0L9
name: Transmembrane protein LOC653160
length: 218
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:


uniprotID: Q86UX7
geneSymbol: FERMT3
reactome: R-HSA-114608;
pdb: 2YS3;
name: Fermitin family homolog 3 (Kindlin-3) (MIG2-like protein) (Unc-112-related protein 2)
length: 667
go: ENSG00000149781;
sequence:

opentargets:
cell junction [GO:0030054]; cell projection [GO:0042995]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; membrane [GO:0016020]; platelet alpha granule lumen [GO:0031093]; podosome [GO:0002102]; integrin binding [GO:0005178]; integrin activation [GO:0033622]; integrin-mediated signaling pathway [GO:0007229]; leukocyte cell-cell adhesion [GO:0007159]; platelet aggregation [GO:0070527]; platelet degranulation [GO:0002576]; positive regulation of cell migration [GO:0030335]; regulation of cell-cell adhesion mediated by integrin [GO:0033632]; substrate adhesion-dependent cell spreading [GO:0034446]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Long, URP2LF; IsoId=Q86UX7-1; Sequence=Displayed; Name=2; Synonyms=Short, URP2SF; IsoId=Q86UX7-2; Sequence=VSP_009226; 

location:
SUBCELLULAR LOCATION: Cell projection, podosome {ECO:0000250}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. {ECO:0000250}.


uniprotID: Q93008
geneSymbol: USP9X
reactome: R-HSA-2173795;R-HSA-5689880;R-HSA-8866652;R-HSA-9033241;R-HSA-977225;
pdb: 5VBD;5WCH;
length: 2570
go: ENSG00000124486;
snps: rs587777317 rs587777319
name:
Probable ubiquitin carboxyl-terminal hydrolase FAF-X (EC 3.4.19.12) (Deubiquitinating enzyme FAF-X) (Fat facets in mammals) (hFAM) (Fat facets protein-related, X-linked) (Ubiquitin thioesterase FAF-X) (Ubiquitin-specific protease 9, X chromosome) (Ubiquitin-specific-processing protease FAF-X)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; growth cone [GO:0030426]; membrane [GO:0016020]; co-SMAD binding [GO:0070410]; cysteine-type endopeptidase activity [GO:0004197]; cysteine-type peptidase activity [GO:0008234]; Lys48-specific deubiquitinase activity [GO:1990380]; thiol-dependent ubiquitin-specific protease activity [GO:0004843]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]; ubiquitinyl hydrolase activity [GO:0101005]; axon extension [GO:0048675]; BMP signaling pathway [GO:0030509]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular protein metabolic process [GO:0044267]; chromosome segregation [GO:0007059]; female gamete generation [GO:0007292]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neuron migration [GO:0001764]; positive regulation of DNA demethylation [GO:1901537]; protein deubiquitination [GO:0016579]; protein stabilization [GO:0050821]; protein targeting to peroxisome [GO:0006625]; transforming growth factor beta receptor signaling pathway [GO:0007179]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Long; IsoId=Q93008-3; Sequence=Displayed; Name=2; Synonyms=Short; IsoId=Q93008-1; Sequence=VSP_040478; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19135894}. Cell projection, growth cone {ECO:0000269|PubMed:24607389}.


uniprotID: Q96IX5
geneSymbol: ATP5MD
sequence: MAGPESDAQYQFTGIKKYFNSYTLTGRMNCVLATYGSIALIVLYFKLRSKKTPAVKAT
length: 58
go: ENSG00000173915;
name:
Up-regulated during skeletal muscle growth protein 5 (ATP synthase membrane subunit DAPIT) (Diabetes-associated protein in insulin-sensitive tissues) (HCV F-transactivated protein 2)

opentargets:
integral component of membrane [GO:0016021]; mitochondrial proton-transporting ATP synthase complex [GO:0005753]; mitochondrion [GO:0005739]

location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.


uniprotID: Q68DE3
geneSymbol: USF3
name: Basic helix-loop-helix domain-containing protein USF3 (Upstream transcription factor 3)
length: 2245
snps: rs9866806 rs9852318 rs6770105 rs2290477 rs930818
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; negative regulation of epithelial to mesenchymal transition [GO:0010719]


uniprotID: Q8TD47
geneSymbol: RPS4Y2
name: 40S ribosomal protein S4, Y isoform 2 (Small ribosomal subunit protein eS4)
length: 263
go: ENSG00000280969;
sequence:

opentargets:
cytosolic small ribosomal subunit [GO:0022627]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]


uniprotID: P48067
geneSymbol: SLC6A9
reactome: R-HSA-442660;
length: 706
go: ENSG00000196517;
drug: DB00145;
snps: rs1057519313
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
name:
Sodium- and chloride-dependent glycine transporter 1 (GlyT-1) (GlyT1) (Solute carrier family 6 member 9)

sequence:

opentargets:
hippocampal mossy fiber to CA3 synapse [GO:0098686]; integral component of plasma membrane [GO:0005887]; integral component of postsynaptic membrane [GO:0099055]; integral component of presynaptic membrane [GO:0099056]; integral component of synaptic vesicle membrane [GO:0030285]; membrane [GO:0016020]; parallel fiber to Purkinje cell synapse [GO:0098688]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; glycine transmembrane transporter activity [GO:0015187]; glycine:sodium symporter activity [GO:0015375]; glycine secretion, neurotransmission [GO:0061537]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=GlyT-1C; IsoId=P48067-1; Sequence=Displayed; Name=GlyT-1A; IsoId=P48067-2; Sequence=VSP_006270; Name=GlyT-1B; IsoId=P48067-3; Sequence=VSP_006271; 


uniprotID: Q6AZY7
geneSymbol: SCARA3
name: Scavenger receptor class A member 3 (Cellular stress response gene protein)
length: 606
go: ENSG00000168077;
snps: rs34791518 rs33930667 rs3735754 rs34086286 rs17057523 rs35928641
sequence:

opentargets:
collagen trimer [GO:0005581]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; calcium ion binding [GO:0005509]; mannose binding [GO:0005537]; scavenger receptor activity [GO:0005044]; complement activation, lectin pathway [GO:0001867]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; response to oxidative stress [GO:0006979]; UV protection [GO:0009650]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=CSR1; IsoId=Q6AZY7-1; Sequence=Displayed; Name=2; Synonyms=CSR2; IsoId=Q6AZY7-2; Sequence=VSP_017135, VSP_017136; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9580669}; Single-pass type II membrane protein {ECO:0000269|PubMed:9580669}. Golgi apparatus membrane {ECO:0000269|PubMed:9580669}; Single-pass type II membrane protein {ECO:0000269|PubMed:9580669}. Note=Endoplasmic reticulum and/or Golgi.


uniprotID: O15126
geneSymbol: SCAMP1
reactome: R-HSA-6798695;
name: Secretory carrier-associated membrane protein 1 (Secretory carrier membrane protein 1)
length: 338
go: ENSG00000085365;
sequence:

opentargets:
clathrin-coated vesicle [GO:0030136]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; recycling endosome membrane [GO:0055038]; specific granule membrane [GO:0035579]; synaptic vesicle membrane [GO:0030672]; trans-Golgi network [GO:0005802]; trans-Golgi network membrane [GO:0032588]; zymogen granule membrane [GO:0042589]; neutrophil degranulation [GO:0043312]; post-Golgi vesicle-mediated transport [GO:0006892]; protein transport [GO:0015031]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15126-1; Sequence=Displayed; Name=2; IsoId=O15126-2; Sequence=VSP_004380; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}. Recycling endosome membrane {ECO:0000269|PubMed:15840657}; Multi-pass membrane protein {ECO:0000269|PubMed:15840657}.


uniprotID: Q96NL6
geneSymbol: SCLT1
reactome: R-HSA-5620912;
name: Sodium channel and clathrin linker 1 (Sodium channel-associated protein 1)
length: 688
go: ENSG00000151466;
snps: rs10028124
sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; ciliary transition fiber [GO:0097539]; clathrin complex [GO:0071439]; cytosol [GO:0005829]; clathrin binding [GO:0030276]; protein C-terminus binding [GO:0008022]; sodium channel regulator activity [GO:0017080]; ciliary basal body-plasma membrane docking [GO:0097711]; cilium assembly [GO:0060271]; clustering of voltage-gated sodium channels [GO:0045162]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q96NL6-1; Sequence=Displayed; Name=2; IsoId=Q96NL6-2; Sequence=VSP_030907; Note=No experimental confirmation available.; Name=3; IsoId=Q96NL6-3; Sequence=VSP_030906; Note=No experimental confirmation available.; Name=4; IsoId=Q96NL6-4; Sequence=VSP_030904, VSP_030905; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23348840}. Note=Localizes to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane.


uniprotID: P57086
geneSymbol: SCAND1
name: SCAN domain-containing protein 1
length: 179
go: ENSG00000171222;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:
MAATEPILAATGSPAAVPPEKLEGAGSSSAPERNCVGSSLPEASPPAPEPSSPNAAVPEAIPTPRAAASAALELPLGPAPVSVAPQAEAEARSTPGPAGSRLGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRPDIRTKEQIVEMLVQEQLLAILPEAARARRIRRRTDVRITG

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; transcription coactivator activity [GO:0003713]


uniprotID: Q9BWG6
geneSymbol: SCNM1
name: Sodium channel modifier 1
length: 230
go: ENSG00000163156;
sequence:

opentargets:
nuclear speck [GO:0016607]; nucleus [GO:0005634]; enzyme binding [GO:0019899]; metal ion binding [GO:0046872]; alternative mRNA splicing, via spliceosome [GO:0000380]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BWG6-1; Sequence=Displayed; Name=2; IsoId=Q9BWG6-2; Sequence=VSP_021489; Name=3; IsoId=Q9BWG6-3; Sequence=VSP_053982, VSP_053983; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17656373}. Nucleus speckle {ECO:0000269|PubMed:17656373}. Note=Colocalizes with LUC7L2 and SNRNP70 in nuclear speckles. {ECO:0000250|UniProtKB:Q8K136}.


uniprotID: P51172
geneSymbol: SCNN1D
reactome: R-HSA-2672351;
length: 638
go: ENSG00000162572;
drug: DB00594;DB00384;
snps: rs11260579 rs2228579 rs13306651 rs1053844 rs6690013 rs609805
name:
Amiloride-sensitive sodium channel subunit delta (Delta-NaCH) (Epithelial Na(+) channel subunit delta) (Delta-ENaC) (ENaCD) (Nonvoltage-gated sodium channel 1 subunit delta) (SCNED)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; plasma membrane [GO:0005886]; ligand-gated sodium channel activity [GO:0015280]; response to stimulus [GO:0050896]; sensory perception of taste [GO:0050909]; sodium ion transport [GO:0006814]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=delta1; IsoId=P51172-1; Sequence=Displayed; Name=2; Synonyms=delta2; IsoId=P51172-2; Sequence=VSP_007725; Note=Channels including isoform 2 exhibit greater conductance than those containing isoform 1. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19520916}; Multi-pass membrane protein {ECO:0000269|PubMed:19520916}.


uniprotID: O75880
geneSymbol: SCO1
reactome: R-HSA-5628897;R-HSA-611105;
pdb: 1WP0;2GGT;2GQK;2GQL;2GQM;2GT5;2GT6;2GVP;2HRF;2HRN;
name: Protein SCO1 homolog, mitochondrial
length: 301
go: ENSG00000133028;
snps: rs1802083 rs104894630
sequence:

opentargets:
host cell mitochondrial intermembrane space [GO:0072492]; integral component of mitochondrial inner membrane [GO:0031305]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; copper ion binding [GO:0005507]; cellular copper ion homeostasis [GO:0006878]; copper ion transport [GO:0006825]; generation of precursor metabolites and energy [GO:0006091]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; negative regulation of proteasomal protein catabolic process [GO:1901799]; respiratory chain complex IV assembly [GO:0008535]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:9878253}. Mitochondrion inner membrane {ECO:0000269|PubMed:15229189}; Single-pass membrane protein {ECO:0000255}.


uniprotID: O43819
geneSymbol: SCO2
reactome: R-HSA-5628897;R-HSA-611105;
pdb: 2RLI;
name: Protein SCO2 homolog, mitochondrial
length: 266
go: ENSG00000130489;
sequence:

opentargets:
integral component of mitochondrial inner membrane [GO:0031305]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; myofibril [GO:0030016]; copper ion binding [GO:0005507]; protein disulfide oxidoreductase activity [GO:0015035]; cell redox homeostasis [GO:0045454]; cellular copper ion homeostasis [GO:0006878]; copper ion transport [GO:0006825]; eye development [GO:0001654]; mitochondrial respiratory chain complex IV assembly [GO:0033617]; oxidation-reduction process [GO:0055114]

snps:
rs140523 rs370130010 rs145100473 rs375954523 rs28937868 rs74315511 rs28937598 rs759452074 rs80358232 rs8139305 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:15229189}; Single-pass membrane protein {ECO:0000255}.


uniprotID: Q9BYC2
geneSymbol: OXCT2
reactome: R-HSA-77108;
length: 517
go: ENSG00000198754;
drug: DB00139;
snps: rs7542609 rs230321
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11756565}.
name:
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial (EC 2.8.3.5) (3-oxoacid CoA-transferase 2A) (Testis-specific succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-t)

sequence:

opentargets:
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; motile cilium [GO:0031514]; 3-oxoacid CoA-transferase activity [GO:0008260]; ketone body catabolic process [GO:0046952]


uniprotID: P18827
geneSymbol: SDC1
pdb: 4GVC;4GVD;6EJE;
name: Syndecan-1 (SYND1) (CD antigen CD138)
length: 310
go: ENSG00000115884;
snps: rs2230922 rs10205485
reactome:
R-HSA-1971475;R-HSA-2022928;R-HSA-2024096;R-HSA-202733;R-HSA-3000170;R-HSA-3560783;R-HSA-3560801;R-HSA-3656237;R-HSA-3656253;R-HSA-4420332;R-HSA-449836;R-HSA-975634;

sequence:

opentargets:
cell surface [GO:0009986]; external side of plasma membrane [GO:0009897]; extracellular exosome [GO:0070062]; Golgi lumen [GO:0005796]; integral component of plasma membrane [GO:0005887]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; identical protein binding [GO:0042802]; protein C-terminus binding [GO:0008022]; canonical Wnt signaling pathway [GO:0060070]; cytokine-mediated signaling pathway [GO:0019221]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; inflammatory response [GO:0006954]; leukocyte migration [GO:0050900]; myoblast development [GO:0048627]; odontogenesis [GO:0042476]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; response to calcium ion [GO:0051592]; response to cAMP [GO:0051591]; response to glucocorticoid [GO:0051384]; response to hydrogen peroxide [GO:0042542]; retinoid metabolic process [GO:0001523]; Sertoli cell development [GO:0060009]; striated muscle cell development [GO:0055002]; ureteric bud development [GO:0001657]; wound healing [GO:0042060]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:9169435}. Secreted, exosome {ECO:0000269|PubMed:22660413}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:9169435}.


uniprotID: P34741
geneSymbol: SDC2
length: 201
go: ENSG00000169439;
drug: DB00020;
snps: rs3816208 rs1042381
location: SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
reactome:
R-HSA-1971475;R-HSA-2022928;R-HSA-2024096;R-HSA-202733;R-HSA-3000170;R-HSA-3560783;R-HSA-3560801;R-HSA-3656237;R-HSA-3656253;R-HSA-381426;R-HSA-3928662;R-HSA-4420332;R-HSA-8957275;R-HSA-975634;

name:
Syndecan-2 (SYND2) (Fibroglycan) (Heparan sulfate proteoglycan core protein) (HSPG) (CD antigen CD362)

sequence:

opentargets:
cell surface [GO:0009986]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum lumen [GO:0005788]; Golgi lumen [GO:0005796]; integral component of membrane [GO:0016021]; lysosomal lumen [GO:0043202]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; PDZ domain binding [GO:0030165]; cellular protein metabolic process [GO:0044267]; dendrite morphogenesis [GO:0048813]; ephrin receptor signaling pathway [GO:0048013]; glycosaminoglycan biosynthetic process [GO:0006024]; glycosaminoglycan catabolic process [GO:0006027]; leukocyte migration [GO:0050900]; post-translational protein modification [GO:0043687]; regulation of dendrite morphogenesis [GO:0048814]; retinoid metabolic process [GO:0001523]


uniprotID: O00560
geneSymbol: SDCBP
reactome: R-HSA-3928664;R-HSA-447043;R-HSA-6798695;
pdb: 1N99;1NTE;1OBX;1OBY;1OBZ;1R6J;1V1T;1W9E;1W9O;1W9Q;1YBO;4Z33;
length: 298
go: ENSG00000137575;
snps: rs1127509
name:
Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)

sequence:

opentargets:
adherens junction [GO:0005912]; azurophil granule lumen [GO:0035578]; blood microparticle [GO:0072562]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; extracellular vesicle [GO:1903561]; focal adhesion [GO:0005925]; interleukin-5 receptor complex [GO:0005895]; intracellular membrane-bounded organelle [GO:0043231]; melanosome [GO:0042470]; membrane [GO:0016020]; membrane raft [GO:0045121]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; cytoskeletal adaptor activity [GO:0008093]; frizzled binding [GO:0005109]; identical protein binding [GO:0042802]; interleukin-5 receptor binding [GO:0005137]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein heterodimerization activity [GO:0046982]; protein N-terminus binding [GO:0047485]; syndecan binding [GO:0045545]; actin cytoskeleton organization [GO:0030036]; chemical synaptic transmission [GO:0007268]; ephrin receptor signaling pathway [GO:0048013]; intracellular signal transduction [GO:0035556]; negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435]; negative regulation of receptor internalization [GO:0002091]; neutrophil degranulation [GO:0043312]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of exosomal secretion [GO:1903543]; positive regulation of extracellular exosome assembly [GO:1903553]; positive regulation of JNK cascade [GO:0046330]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of phosphorylation [GO:0042327]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein targeting to membrane [GO:0006612]; regulation of mitotic cell cycle [GO:0007346]; substrate-dependent cell migration, cell extension [GO:0006930]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O00560-1; Sequence=Displayed; Name=2; IsoId=O00560-2; Sequence=VSP_038375; Name=3; IsoId=O00560-3; Sequence=VSP_038374; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11179419}. Cell junction, adherens junction {ECO:0000269|PubMed:11179419}. Cell membrane {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:25893292, ECO:0000269|PubMed:27386966}; Peripheral membrane protein {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:27386966}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17081065}; Peripheral membrane protein {ECO:0000269|PubMed:17081065}. Nucleus {ECO:0000269|PubMed:11179419}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasm, cytosol {ECO:0000269|PubMed:11179419}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11179419}. Secreted, exosome {ECO:0000269|PubMed:22660413}. Membrane raft {ECO:0000269|PubMed:25893292}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966). {ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:27386966}.


uniprotID: Q9H190
geneSymbol: SDCBP2
name: Syntenin-2 (Similar to TACIP18) (SITAC) (Syndecan-binding protein 2)
length: 292
go: ENSG00000125775;
snps: rs2273959 rs35367003 rs1048621 rs4814111
sequence:

opentargets:
cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; identical protein binding [GO:0042802]; phosphatidylinositol-4,5-bisphosphate binding [GO:0005546]; protein C-terminus binding [GO:0008022]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; cell proliferation [GO:0008283]; intracellular signal transduction [GO:0035556]; intracellular transport [GO:0046907]; nervous system development [GO:0007399]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Alpha; IsoId=Q9H190-1; Sequence=Displayed; Name=3; Synonyms=Beta; IsoId=Q9H190-3; Sequence=VSP_006352; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15961997}. Nucleus, nucleolus {ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23300061}. Cell membrane {ECO:0000269|PubMed:15961997}. Nucleus speckle {ECO:0000269|PubMed:15961997}. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). {ECO:0000269|PubMed:11102519, ECO:0000269|PubMed:15961997, ECO:0000269|PubMed:23300061}.


uniprotID: Q99470
geneSymbol: SDF2
name: Stromal cell-derived factor 2 (SDF-2)
length: 211
go: ENSG00000132581;
drug: DB02201;
snps: rs35404078
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; extracellular space [GO:0005615]; dolichyl-phosphate-mannose-protein mannosyltransferase activity [GO:0004169]; ER-associated misfolded protein catabolic process [GO:0071712]; protein glycosylation [GO:0006486]


uniprotID: P31040
geneSymbol: SDHA
reactome: R-HSA-611105;R-HSA-71403;
length: 664
go: ENSG00000073578;
drug: DB04657;DB00139;DB04795;DB08689;
name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (EC 1.3.5.1) (Flavoprotein subunit of complex II) (Fp)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) [GO:0005749]; mitochondrion [GO:0005739]; myelin sheath [GO:0043209]; nucleolus [GO:0005730]; plasma membrane succinate dehydrogenase complex [GO:0045282]; electron transfer activity [GO:0009055]; flavin adenine dinucleotide binding [GO:0050660]; succinate dehydrogenase (ubiquinone) activity [GO:0008177]; succinate dehydrogenase activity [GO:0000104]; anaerobic respiration [GO:0009061]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; nervous system development [GO:0007399]; oxidation-reduction process [GO:0055114]; respiratory electron transport chain [GO:0022904]; succinate metabolic process [GO:0006105]; tricarboxylic acid cycle [GO:0006099]

snps:
rs1061518 rs34635677 rs1041946 rs1062468 rs137852767 rs9809219 rs137852768 rs387906780 rs6960 rs6962 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P31040-1; Sequence=Displayed; Name=2; IsoId=P31040-2; Sequence=VSP_055077; Note=No experimental confirmation available.; Name=3; IsoId=P31040-3; Sequence=VSP_055078; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q0QF01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q0QF01}; Matrix side {ECO:0000250|UniProtKB:Q0QF01}.


uniprotID: Q9NX18
geneSymbol: SDHAF2
name: Succinate dehydrogenase assembly factor 2, mitochondrial (SDH assembly factor 2) (SDHAF2)
length: 166
go: ENSG00000167985;
snps: rs113560320
sequence:
MAVSTVFSTSSLMLALSRHSLLSPLLSVTSFRRFYRGDSPTDSQKDMIEIPLPPWQERTDESIETKRARLLYESRKRGMLENCILLSLFAKEHLQHMTEKQLNLYDRLINEPSNDWDIYYWATEAKPAPEIFENEVMALLRDFAKNKNKEQRLRAPDLEYLFEKPR

opentargets:
cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; mitochondrial electron transport, succinate to ubiquinone [GO:0006121]; mitochondrial respiratory chain complex II assembly [GO:0034553]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of epithelial to mesenchymal transition [GO:0010719]; protein dephosphorylation [GO:0006470]; protein-FAD linkage [GO:0018293]; tricarboxylic acid cycle [GO:0006099]

location:
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000255|HAMAP-Rule:MF_03057, ECO:0000269|PubMed:19628817}.


uniprotID: Q9H7L9
geneSymbol: SUDS3
reactome: R-HSA-3214815;R-HSA-427413;R-HSA-5689880;
length: 328
go: ENSG00000111707;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21239494}.
name:
Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Sin3 complex [GO:0016580]; Sin3-type complex [GO:0070822]; enzyme binding [GO:0019899]; histone deacetylase activity [GO:0004407]; histone deacetylase binding [GO:0042826]; apoptotic process [GO:0006915]; histone deacetylation [GO:0016575]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of apoptotic process [GO:0043065]; substantia nigra development [GO:0021762]


uniprotID: Q96GA7
geneSymbol: SDSL
reactome: R-HSA-8849175;
pdb: 2RKB;
length: 329
go: ENSG00000139410;
drug: DB00114;
name:
Serine dehydratase-like (L-serine deaminase) (L-serine dehydratase/L-threonine deaminase) (L-threonine dehydratase) (TDH) (EC 4.3.1.19) (Serine dehydratase 2) (SDH 2) (EC 4.3.1.17)

sequence:

opentargets:
cytosol [GO:0005829]; hydro-lyase activity [GO:0016836]; identical protein binding [GO:0042802]; L-serine ammonia-lyase activity [GO:0003941]; L-threonine ammonia-lyase activity [GO:0004794]; pyridoxal phosphate binding [GO:0030170]; L-serine catabolic process [GO:0006565]; L-threonine catabolic process to glycine [GO:0019518]; threonine catabolic process [GO:0006567]


uniprotID: Q9UBV2
geneSymbol: SEL1L
reactome: R-HSA-1912420;R-HSA-382556;R-HSA-5358346;R-HSA-5362768;R-HSA-5678895;R-HSA-901032;
name: Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)
length: 794
go: ENSG00000071537;
snps: rs11499034 rs1051193
sequence:

opentargets:
Derlin-1 retrotranslocation complex [GO:0036513]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; Hrd1p ubiquitin ligase complex [GO:0000836]; Hrd1p ubiquitin ligase ERAD-L complex [GO:0000839]; integral component of membrane [GO:0016021]; endoplasmic reticulum mannose trimming [GO:1904380]; ERAD pathway [GO:0036503]; Notch signaling pathway [GO:0007219]; protein secretion [GO:0009306]; protein stabilization [GO:0050821]; retrograde protein transport, ER to cytosol [GO:0030970]; transmembrane transport [GO:0055085]; triglyceride metabolic process [GO:0006641]; ubiquitin-dependent ERAD pathway [GO:0030433]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UBV2-1; Sequence=Displayed; Name=2; IsoId=Q9UBV2-2; Sequence=VSP_013322, VSP_013323; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16186509}; Single-pass type I membrane protein {ECO:0000269|PubMed:16186509}.


uniprotID: Q9H3T2
geneSymbol: SEMA6C
name: Semaphorin-6C (Semaphorin-Y) (Sema Y)
length: 930
go: ENSG00000143434;
snps: rs4971007
location: SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; extracellular space [GO:0005615]; integral component of plasma membrane [GO:0005887]; chemorepellent activity [GO:0045499]; neuropilin binding [GO:0038191]; semaphorin receptor binding [GO:0030215]; axon guidance [GO:0007411]; negative chemotaxis [GO:0050919]; negative regulation of axon extension [GO:0030517]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neural crest cell migration [GO:0001755]; positive regulation of cell migration [GO:0030335]; semaphorin-plexin signaling pathway [GO:0071526]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Short 1; IsoId=Q9H3T2-1; Sequence=Displayed; Name=2; Synonyms=Short 2; IsoId=Q9H3T2-2; Sequence=VSP_006046, VSP_006047; Name=3; Synonyms=Long; IsoId=Q9H3T2-3; Sequence=VSP_006047; 


