# annotation

uniprotID: P56706
geneSymbol: WNT7B
reactome: R-HSA-3238698;R-HSA-373080;
name: Protein Wnt-7b
length: 349
go: ENSG00000188064;
sequence:

opentargets:
endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; activation of JUN kinase activity [GO:0007257]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular metabolic process [GO:0044237]; cellular response to retinoic acid [GO:0071300]; central nervous system vasculogenesis [GO:0022009]; chorio-allantoic fusion [GO:0060710]; developmental growth involved in morphogenesis [GO:0060560]; embryonic organ development [GO:0048568]; embryonic placenta morphogenesis [GO:0060669]; establishment or maintenance of polarity of embryonic epithelium [GO:0016332]; fibroblast proliferation [GO:0048144]; forebrain regionalization [GO:0021871]; homeostatic process [GO:0042592]; in utero embryonic development [GO:0001701]; inner medullary collecting duct development [GO:0072061]; lens fiber cell development [GO:0070307]; lobar bronchus development [GO:0060482]; lung development [GO:0030324]; lung epithelium development [GO:0060428]; lung morphogenesis [GO:0060425]; mammary gland epithelium development [GO:0061180]; metanephric collecting duct development [GO:0072205]; metanephric epithelium development [GO:0072207]; metanephric loop of Henle development [GO:0072236]; metanephros morphogenesis [GO:0003338]; neuron differentiation [GO:0030182]; neuron projection morphogenesis [GO:0048812]; outer medullary collecting duct development [GO:0072060]; oxygen homeostasis [GO:0032364]; positive regulation of JNK cascade [GO:0046330]; positive regulation of osteoblast differentiation [GO:0045669]; regulation of cell projection size [GO:0032536]; renal inner medulla development [GO:0072053]; renal outer medulla development [GO:0072054]; response to glucocorticoid [GO:0051384]; stem cell proliferation [GO:0072089]; synapse organization [GO:0050808]; trachea cartilage morphogenesis [GO:0060535]; Wnt signaling pathway [GO:0016055]


uniprotID: Q9UEU0
geneSymbol: VTI1B
reactome: R-HSA-114608;
pdb: 2V8S;
length: 232
go: ENSG00000100568;
name:
Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)

sequence:

opentargets:
cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endoplasmic reticulum membrane [GO:0005789]; ER to Golgi transport vesicle membrane [GO:0012507]; extracellular region [GO:0005576]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; platelet alpha granule lumen [GO:0031093]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; SNARE complex [GO:0031201]; synaptic vesicle [GO:0008021]; vesicle [GO:0031982]; chloride channel inhibitor activity [GO:0019869]; SNAP receptor activity [GO:0005484]; SNARE binding [GO:0000149]; cell proliferation [GO:0008283]; ER to Golgi vesicle-mediated transport [GO:0006888]; Golgi to vacuole transport [GO:0006896]; intra-Golgi vesicle-mediated transport [GO:0006891]; membrane fusion [GO:0061025]; platelet degranulation [GO:0002576]; protein targeting to vacuole [GO:0006623]; regulation of protein localization to plasma membrane [GO:1903076]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle fusion with Golgi apparatus [GO:0048280]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=Long; IsoId=Q9UEU0-1; Sequence=Displayed; Name=Short; IsoId=Q9UEU0-2; Sequence=VSP_006753; 

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:18033301}; Single-pass type IV membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:18033301, ECO:0000269|PubMed:23217709}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23217709}. Lysosome membrane {ECO:0000269|PubMed:18033301, ECO:0000269|PubMed:23217709}. Cytoplasmic granule {ECO:0000269|PubMed:23217709}. Recycling endosome membrane {ECO:0000269|PubMed:18033301}; Single-pass type IV membrane protein {ECO:0000255}.


uniprotID: A2RUG3
geneSymbol: XKRY2
name: Testis-specific XK-related protein, Y-linked 2
length: 117
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:
MFIFNSIADDIFPLISCVGAIHCNILAIRTGNDFAAIKLQVIKLIYLMIWHSLVIISPVVTLAFFPASLKQGSLHFLLIIYFVLLLTPWLEFSKSGTHLPSNTKNNSSMVGKYGCLS


uniprotID: Q9GZS3
geneSymbol: WDR61
reactome: R-HSA-112382;R-HSA-429958;R-HSA-674695;R-HSA-75955;R-HSA-8866654;
pdb: 3OW8;6GMH;
length: 305
go: ENSG00000140395;
name:
WD repeat-containing protein 61 (Meiotic recombination REC14 protein homolog) (SKI8 homolog) (Ski8) [Cleaved into: WD repeat-containing protein 61, N-terminally processed]

sequence:

opentargets:
Cdc73/Paf1 complex [GO:0016593]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Ski complex [GO:0055087]; transcriptionally active chromatin [GO:0035327]; exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay [GO:0043928]; histone H3-K4 trimethylation [GO:0080182]; negative regulation of myeloid cell differentiation [GO:0045638]; positive regulation of histone H3-K4 methylation [GO:0051571]; positive regulation of histone H3-K79 methylation [GO:2001162]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription elongation from RNA polymerase II promoter [GO:0032968]; protein ubiquitination [GO:0016567]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000305|PubMed:16024656}.


uniprotID: Q6GPH4
geneSymbol: XAF1
reactome: R-HSA-909733;
pdb: 2LXW;
name: XIAP-associated factor 1 (BIRC4-binding protein)
length: 301
go: ENSG00000132530;
snps: rs34195599 rs2271232 rs34625877 rs3736433
sequence:

opentargets:
cytosol [GO:0005829]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; response to interferon-beta [GO:0035456]; type I interferon signaling pathway [GO:0060337]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=XAF1(A); IsoId=Q6GPH4-1; Sequence=Displayed; Name=2; Synonyms=XAF1B; IsoId=Q6GPH4-2; Sequence=VSP_032919; Name=3; Synonyms=D; IsoId=Q6GPH4-3; Sequence=VSP_032923; Name=4; Synonyms=E; IsoId=Q6GPH4-4; Sequence=VSP_032919, VSP_032923; Name=5; Synonyms=XAF1C; IsoId=Q6GPH4-5; Sequence=VSP_032922; Name=6; IsoId=Q6GPH4-6; Sequence=VSP_032918, VSP_032921; Name=7; IsoId=Q6GPH4-7; Sequence=VSP_032920; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.; SUBCELLULAR LOCATION: Isoform 1: Nucleus.; SUBCELLULAR LOCATION: Isoform 5: Nucleus.


uniprotID: P04004
geneSymbol: VTN
reactome: R-HSA-2129379;R-HSA-216083;R-HSA-3000170;R-HSA-3000178;R-HSA-977606;
pdb: 1OC0;1S4G;1SSU;2JQ8;3BT1;3BT2;4K24;
length: 478
go: ENSG00000109072;
drug: DB00054;
snps: rs2227741 rs2227723 rs704
location: SUBCELLULAR LOCATION: Secreted, extracellular space.
name:
Vitronectin (VN) (S-protein) (Serum-spreading factor) (V75) [Cleaved into: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin-B]

sequence:

opentargets:
alphav-beta3 integrin-vitronectin complex [GO:0071062]; basement membrane [GO:0005604]; blood microparticle [GO:0072562]; collagen-containing extracellular matrix [GO:0062023]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; intracellular membrane-bounded organelle [GO:0043231]; rough endoplasmic reticulum lumen [GO:0048237]; collagen binding [GO:0005518]; extracellular matrix binding [GO:0050840]; extracellular matrix structural constituent [GO:0005201]; heparin binding [GO:0008201]; identical protein binding [GO:0042802]; integrin binding [GO:0005178]; polysaccharide binding [GO:0030247]; scavenger receptor activity [GO:0005044]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cell migration [GO:0016477]; cell proliferation [GO:0008283]; cell-matrix adhesion [GO:0007160]; endodermal cell differentiation [GO:0035987]; extracellular matrix organization [GO:0030198]; immune response [GO:0006955]; liver regeneration [GO:0097421]; negative regulation of blood coagulation [GO:0030195]; negative regulation of endopeptidase activity [GO:0010951]; oligodendrocyte differentiation [GO:0048709]; positive regulation of cell-substrate adhesion [GO:0010811]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of protein binding [GO:0032092]; positive regulation of receptor-mediated endocytosis [GO:0048260]; positive regulation of smooth muscle cell migration [GO:0014911]; positive regulation of vascular endothelial growth factor receptor signaling pathway [GO:0030949]; positive regulation of wound healing [GO:0090303]; protein polymerization [GO:0051258]; regulation of complement activation [GO:0030449]; smooth muscle cell-matrix adhesion [GO:0061302]


uniprotID: Q9H4A3
geneSymbol: WNK1
reactome: R-HSA-2672351;
pdb: 4PWN;5TF9;5WDY;5WE8;6FBK;
length: 2382
go: ENSG00000060237;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10660600}.
name:
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; chloride channel inhibitor activity [GO:0019869]; magnesium ion binding [GO:0000287]; phosphatase binding [GO:0019902]; potassium channel inhibitor activity [GO:0019870]; protein kinase activator activity [GO:0030295]; protein kinase activity [GO:0004672]; protein kinase binding [GO:0019901]; protein serine/threonine kinase activity [GO:0004674]; protein serine/threonine kinase inhibitor activity [GO:0030291]; cellular response to calcium ion [GO:0071277]; cellular response to chemokine [GO:1990869]; chemokine (C-C motif) ligand 21 signaling pathway [GO:0038116]; intracellular signal transduction [GO:0035556]; ion homeostasis [GO:0050801]; ion transport [GO:0006811]; lymphocyte migration into lymph node [GO:0097022]; negative regulation of cell-cell adhesion mediated by integrin [GO:0033633]; negative regulation of GTPase activity [GO:0034260]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of leukocyte cell-cell adhesion [GO:1903038]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of sodium ion transport [GO:0010766]; neuron development [GO:0048666]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of canonical Wnt signaling pathway [GO:0090263]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion import [GO:1903288]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; positive regulation of systemic arterial blood pressure [GO:0003084]; positive regulation of T cell chemotaxis [GO:0010820]; protein autophosphorylation [GO:0046777]; protein phosphorylation [GO:0006468]; regulation of cellular process [GO:0050794]; regulation of sodium ion transport [GO:0002028]; signal transduction by trans-phosphorylation [GO:0023016]; T cell receptor signaling pathway [GO:0050852]

snps:
rs11554421 rs34880640 rs34728563 rs34408667 rs2286007 rs11833299 rs56015776 rs956868 rs7955371 rs56351358 rs12828016 rs17755373 rs36083875 rs56262445 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=6;  Comment=WNK1 is a complex 33-exons gene, in total 9 WNK1 exons are alternatively spliced, some expressed in a tissue-specific manner. Additional isoforms seems to exist.; Name=1 {ECO:0000269|PubMed:11571656}; Synonyms=L-WNK1; IsoId=Q9H4A3-1; Sequence=Displayed; Note=Strong expression in dorsal root ganglia and spinal cord.; Name=2 {ECO:0000303|PubMed:9205841}; IsoId=Q9H4A3-2; Sequence=VSP_040269, VSP_050638; Note=No experimental confirmation available. {ECO:0000305}; Name=3; Synonyms=KS-WNK1, Kidney-Specific; IsoId=Q9H4A3-4; Sequence=VSP_050634, VSP_050637; Note=Kinase-defective isoform. Produced by alternative promoter usage and alternative splicing.; Name=4; Synonyms=Brain and spinal cord variant; IsoId=Q9H4A3-5; Sequence=VSP_040268; Note=Contains the nervous system-specific exon HSN2. Produced by alternative splicing.; Name=5; Synonyms=Dorsal root ganglia and sciatic nerve variant, DRG and sciatic nerve variant; IsoId=Q9H4A3-6; Sequence=VSP_040267, VSP_040270; Note=Contains the nervous system-specific exon HSN2. Produced by alternative splicing.; Name=6; IsoId=Q9H4A3-7; Sequence=VSP_040267, VSP_053767; Note=Contains the nervous system-specific exon HSN2. Produced by alternative splicing.; 


uniprotID: O76024
geneSymbol: WFS1
reactome: R-HSA-381038;R-HSA-381426;R-HSA-8957275;
name: Wolframin
length: 890
go: ENSG00000109501;
location: SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
sequence:

opentargets:
dendrite [GO:0030425]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum lumen [GO:0005788]; endoplasmic reticulum membrane [GO:0005789]; integral component of endoplasmic reticulum membrane [GO:0030176]; integral component of synaptic vesicle membrane [GO:0030285]; proteasome complex [GO:0000502]; activating transcription factor binding [GO:0033613]; ATPase binding [GO:0051117]; calcium-dependent protein binding [GO:0048306]; calmodulin binding [GO:0005516]; ubiquitin protein ligase binding [GO:0031625]; calcium ion homeostasis [GO:0055074]; cellular protein metabolic process [GO:0044267]; endoplasmic reticulum calcium ion homeostasis [GO:0032469]; ER overload response [GO:0006983]; glucose homeostasis [GO:0042593]; IRE1-mediated unfolded protein response [GO:0036498]; kidney development [GO:0001822]; negative regulation of ATF6-mediated unfolded protein response [GO:1903892]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902236]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of programmed cell death [GO:0043069]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of type B pancreatic cell apoptotic process [GO:2000675]; nervous system process [GO:0050877]; olfactory behavior [GO:0042048]; pancreas development [GO:0031016]; positive regulation of calcium ion transport [GO:0051928]; positive regulation of growth [GO:0045927]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of protein ubiquitination [GO:0031398]; post-translational protein modification [GO:0043687]; protein maturation by protein folding [GO:0022417]; protein stabilization [GO:0050821]; renal water homeostasis [GO:0003091]; response to endoplasmic reticulum stress [GO:0034976]; sensory perception of sound [GO:0007605]; ubiquitin-dependent ERAD pathway [GO:0030433]; visual perception [GO:0007601]

snps:
rs34653805 rs369671890 rs145639028 rs372249044 rs148953711 rs758281375 rs41264699 rs746923441 rs369795224 rs1801212 rs147974629 rs1801208 rs113446173 rs398123066 rs28937892 rs199946797 rs55814513 rs1805069 rs2230720 rs734312 rs71530910 rs104893882 rs201064551 rs200672755 rs387906930 rs142668478 rs754373473 rs28937891 rs28937894 rs200099217 rs28937893 rs1805070 rs28937890 rs71532864 rs147834269 rs141328044 rs387906931 rs746922325 rs35932623 rs104893883 rs28937895 rs876657675 rs121912618 rs74315205 rs71532874 rs372855769 


uniprotID: Q9BQY6
geneSymbol: WFDC6
name: WAP four-disulfide core domain protein 6 (Putative protease inhibitor WAP6)
length: 131
go: ENSG00000243543;
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MGLSGLLPILVPFILLGDIQEPGHAEGILGKPCPKIKVECEVEEIDQCTKPRDCPENMKCCPFSRGKKCLDFRKIYAVCHRRLAPAWPPYHTGGTIKKTKICSEFIYGGSQGNNNNFQTEAICLVTCKKYH

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of peptidase activity [GO:0010466]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BQY6-1; Sequence=Displayed; Name=2; IsoId=Q9BQY6-2; Sequence=VSP_007550, VSP_007551; Name=3; IsoId=O95925-3; Sequence=External; Note=Based on a readthrough transcript which may produce a EPPIN-WFDC6 fusion protein. No experimental confirmation available.; 


uniprotID: Q9HC57
geneSymbol: WFDC1
name: WAP four-disulfide core domain protein 1 (Prostate stromal protein ps20) (ps20 growth inhibitor)
length: 220
go: ENSG00000103175;
snps: rs11643870 rs35504166 rs12933084
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular space [GO:0005615]; serine-type endopeptidase inhibitor activity [GO:0004867]; negative regulation of cell growth [GO:0030308]; negative regulation of epithelial cell proliferation [GO:0050680]; negative regulation of inflammatory response [GO:0050728]; negative regulation of wound healing [GO:0061045]; regulation of cell growth [GO:0001558]; response to drug [GO:0042493]; response to estradiol [GO:0032355]


uniprotID: Q5TIE3
geneSymbol: VWA5B1
name: von Willebrand factor A domain-containing protein 5B1
length: 1220
go: ENSG00000158816;
opentargets: extracellular region [GO:0005576]
snps: rs2872972 rs2072752 rs12072406 rs10916769
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q5TIE3-1; Sequence=Displayed; Name=2; IsoId=Q5TIE3-2; Sequence=VSP_040399, VSP_040400; Note=No experimental confirmation available.; Name=3; IsoId=Q5TIE3-3; Sequence=VSP_032580, VSP_032581, VSP_032582; Note=No experimental confirmation available.; Name=4; IsoId=Q5TIE3-4; Sequence=VSP_040399, VSP_040401, VSP_040403; Note=No experimental confirmation available.; Name=5; IsoId=Q5TIE3-5; Sequence=VSP_040399, VSP_040402; Note=No experimental confirmation available.; 


uniprotID: P04628
geneSymbol: WNT1
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-381340;R-HSA-4086400;R-HSA-4641262;
name: Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog)
length: 370
go: ENSG00000125084;
snps: rs397514702 rs387907359 rs387907358
sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; cytokine activity [GO:0005125]; frizzled binding [GO:0005109]; morphogen activity [GO:0016015]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; transcription regulatory region DNA binding [GO:0044212]; animal organ regeneration [GO:0031100]; astrocyte-dopaminergic neuron signaling [GO:0036520]; beta-catenin destruction complex disassembly [GO:1904886]; bone development [GO:0060348]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; cell fate commitment [GO:0045165]; cell proliferation in midbrain [GO:0033278]; cell-cell signaling [GO:0007267]; cellular response to peptide hormone stimulus [GO:0071375]; central nervous system morphogenesis [GO:0021551]; cerebellum formation [GO:0021588]; diencephalon development [GO:0021536]; embryonic axis specification [GO:0000578]; embryonic brain development [GO:1990403]; forebrain anterior/posterior pattern specification [GO:0021797]; hematopoietic stem cell proliferation [GO:0071425]; hepatocyte differentiation [GO:0070365]; inner ear morphogenesis [GO:0042472]; midbrain development [GO:0030901]; midbrain-hindbrain boundary maturation during brain development [GO:0022004]; myoblast fusion [GO:0007520]; negative regulation of apoptotic process [GO:0043066]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of cell aging [GO:0090344]; negative regulation of cell-cell adhesion [GO:0022408]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of oxidative stress-induced neuron death [GO:1903204]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; neuron differentiation [GO:0030182]; neuron fate determination [GO:0048664]; positive regulation of cell proliferation [GO:0008284]; positive regulation of dermatome development [GO:0061184]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of insulin-like growth factor receptor signaling pathway [GO:0043568]; positive regulation of lamellipodium assembly [GO:0010592]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; response to wounding [GO:0009611]; signal transduction in response to DNA damage [GO:0042770]; Spemann organizer formation [GO:0060061]; spinal cord association neuron differentiation [GO:0021527]; T cell differentiation in thymus [GO:0033077]; ubiquitin-dependent SMAD protein catabolic process [GO:0030579]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904953]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]


uniprotID: Q9Y5W5
geneSymbol: WIF1
reactome: R-HSA-201681;R-HSA-3772470;
pdb: 2D3J;2YGN;2YGO;2YGP;2YGQ;
name: Wnt inhibitory factor 1 (WIF-1)
length: 379
go: ENSG00000156076;
location: SUBCELLULAR LOCATION: Secreted.
sequence:

opentargets:
cell surface [GO:0009986]; extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; Wnt-protein binding [GO:0017147]; anatomical structure development [GO:0048856]; multicellular organism development [GO:0007275]; negative regulation of Wnt signaling pathway [GO:0030178]; positive regulation of fat cell differentiation [GO:0045600]; signal transduction [GO:0007165]; Wnt signaling pathway [GO:0016055]


uniprotID: Q9C0J8
geneSymbol: WDR33
reactome: R-HSA-109688;R-HSA-159231;R-HSA-72163;R-HSA-72187;R-HSA-77595;
pdb: 6BLY;6BM0;6DNH;6F9N;6FBS;6FUW;
length: 1336
go: ENSG00000136709;
snps: rs11557686 rs12615078
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11162572, ECO:0000269|PubMed:19217410}.
name:
pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)

sequence:

opentargets:
collagen trimer [GO:0005581]; fibrillar center [GO:0001650]; mRNA cleavage and polyadenylation specificity factor complex [GO:0005847]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; mRNA 3'-end processing [GO:0031124]; mRNA export from nucleus [GO:0006406]; mRNA polyadenylation [GO:0006378]; mRNA splicing, via spliceosome [GO:0000398]; postreplication repair [GO:0006301]; spermatogenesis [GO:0007283]; termination of RNA polymerase II transcription [GO:0006369]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9C0J8-1; Sequence=Displayed; Name=2; IsoId=Q9C0J8-2; Sequence=VSP_041333, VSP_041334; Name=3; IsoId=Q9C0J8-3; Sequence=VSP_042684, VSP_042685, VSP_041334; Note=No experimental confirmation available.; 


uniprotID: Q969T9
geneSymbol: WBP2
name: WW domain-binding protein 2 (WBP-2)
length: 261
go: ENSG00000132471;
snps: rs202022024
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear chromatin [GO:0000790]; nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; estrogen receptor binding [GO:0030331]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription coactivator activity [GO:0003713]; cellular response to estrogen stimulus [GO:0071391]; establishment of protein localization [GO:0045184]; positive regulation of gene expression, epigenetic [GO:0045815]; positive regulation of histone H3-K14 acetylation [GO:0071442]; positive regulation of intracellular estrogen receptor signaling pathway [GO:0033148]; positive regulation of transcription by RNA polymerase II [GO:0045944]; progesterone receptor signaling pathway [GO:0050847]; response to estrogen [GO:0043627]; response to progesterone [GO:0032570]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q969T9-1; Sequence=Displayed; Name=2; IsoId=Q969T9-2; Sequence=VSP_059233; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21642474}. Nucleus {ECO:0000269|PubMed:21642474}. Note=Translocates from cytoplasm to nucleus when phosphorylated. {ECO:0000269|PubMed:21642474}.


uniprotID: P30291
geneSymbol: WEE1
reactome: R-HSA-156711;R-HSA-69202;R-HSA-69273;R-HSA-69478;R-HSA-69656;R-HSA-75035;R-HSA-983231;
name: Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)
length: 646
go: ENSG00000166483;
snps: rs34412975 rs56411856
location: SUBCELLULAR LOCATION: Nucleus.
pdb:
1X8B;2IN6;2IO6;2Z2W;3BI6;3BIZ;3CQE;3CR0;5V5Y;5VC3;5VC4;5VC5;5VC6;5VD2;5VD4;5VD5;5VD7;5VD8;5VD9;5VDA;

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; kinase activity [GO:0016301]; magnesium ion binding [GO:0000287]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; protein kinase activity [GO:0004672]; protein tyrosine kinase activity [GO:0004713]; cell division [GO:0051301]; establishment of cell polarity [GO:0030010]; G2/M transition of mitotic cell cycle [GO:0000086]; microtubule cytoskeleton organization [GO:0000226]; mitotic cell cycle checkpoint [GO:0007093]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; neuron projection morphogenesis [GO:0048812]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P30291-1; Sequence=Displayed; Name=2; IsoId=P30291-2; Sequence=VSP_044959; Note=No experimental confirmation available.; 


uniprotID: Q9H977
geneSymbol: WDR54
name: WD repeat-containing protein 54
length: 334
go: ENSG00000005448;
sequence:


uniprotID: Q9NQW7
geneSymbol: XPNPEP1
pdb: 3CTZ;
length: 623
go: ENSG00000108039;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; aminopeptidase activity [GO:0004177]; manganese ion binding [GO:0030145]; metalloaminopeptidase activity [GO:0070006]; protein homodimerization activity [GO:0042803]; bradykinin catabolic process [GO:0010815]; proteolysis [GO:0006508]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1 {ECO:0000269|PubMed:9465902}; IsoId=Q9NQW7-1; Sequence=Displayed; Name=2; IsoId=Q9NQW7-2; Sequence=VSP_051752; Note=No experimental confirmation available. {ECO:0000305}; Name=3; IsoId=Q9NQW7-3; Sequence=VSP_045250; Note=No experimental confirmation available.; Name=4; IsoId=Q9NQW7-4; Sequence=VSP_045250, VSP_051752; 


uniprotID: P56703
geneSymbol: WNT3
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;
name: Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog)
length: 355
go: ENSG00000108379;
sequence:

opentargets:
endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; Wnt signalosome [GO:1990909]; frizzled binding [GO:0005109]; protein domain specific binding [GO:0019904]; receptor ligand activity [GO:0048018]; anterior/posterior axis specification [GO:0009948]; axon guidance [GO:0007411]; canonical Wnt signaling pathway [GO:0060070]; canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation [GO:0044338]; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1904954]; canonical Wnt signaling pathway involved in osteoblast differentiation [GO:0044339]; canonical Wnt signaling pathway involved in stem cell proliferation [GO:1905474]; cell fate commitment [GO:0045165]; cell morphogenesis [GO:0000902]; cellular response to retinoic acid [GO:0071300]; dorsal/ventral axis specification [GO:0009950]; embryonic forelimb morphogenesis [GO:0035115]; embryonic hindlimb morphogenesis [GO:0035116]; gamete generation [GO:0007276]; head morphogenesis [GO:0060323]; limb bud formation [GO:0060174]; mammary gland epithelium development [GO:0061180]; mesoderm formation [GO:0001707]; negative regulation of axon extension involved in axon guidance [GO:0048843]; neuron differentiation [GO:0030182]; positive regulation of collateral sprouting in absence of injury [GO:0048697]; positive regulation of gene expression [GO:0010628]; positive regulation of Wnt signaling pathway [GO:0030177]; regulation of neurogenesis [GO:0050767]; Spemann organizer formation at the anterior end of the primitive streak [GO:0060064]; stem cell proliferation [GO:0072089]; Wnt signaling pathway [GO:0016055]


uniprotID: O75717
geneSymbol: WDHD1
pdb: 2D7L;5GVA;5GVB;5OGS;
name: WD repeat and HMG-box DNA-binding protein 1 (Acidic nucleoplasmic DNA-binding protein 1) (And-1)
length: 1129
go: ENSG00000198554;
snps: rs8020032 rs17128116 rs41309252
location: SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear replication fork [GO:0043596]; nucleoplasm [GO:0005654]; replication fork protection complex [GO:0031298]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; cellular response to DNA damage stimulus [GO:0006974]; DNA repair [GO:0006281]; DNA-dependent DNA replication [GO:0006261]; mitotic cell cycle [GO:0000278]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75717-1; Sequence=Displayed; Name=2; IsoId=O75717-2; Sequence=VSP_054775; Note=No experimental confirmation available. Derived from EST data.; 


uniprotID: Q9Y484
geneSymbol: WDR45
reactome: R-HSA-1632852;
name: WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
length: 360
go: ENSG00000196998;
sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; phagophore assembly site membrane [GO:0034045]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y484-1; Sequence=Displayed; Name=2; IsoId=Q9Y484-2; Sequence=VSP_016976; Note=No experimental confirmation available.; Name=3; IsoId=Q9Y484-3; Sequence=VSP_016975; Note=No experimental confirmation available.; 


uniprotID: P78423
geneSymbol: CX3CL1
reactome: R-HSA-380108;R-HSA-418594;
pdb: 1B2T;1F2L;3ONA;4XT1;4XT3;
length: 397
go: ENSG00000006210;
snps: rs35860084
name:
Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]

sequence:

opentargets:
cell projection [GO:0042995]; cell surface [GO:0009986]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; integral component of membrane [GO:0016021]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; CCR chemokine receptor binding [GO:0048020]; chemoattractant activity [GO:0042056]; chemokine activity [GO:0008009]; CX3C chemokine receptor binding [GO:0031737]; CXCR1 chemokine receptor binding [GO:0045237]; integrin binding [GO:0005178]; signaling receptor binding [GO:0005102]; aging [GO:0007568]; angiogenesis involved in wound healing [GO:0060055]; autocrine signaling [GO:0035425]; cell adhesion [GO:0007155]; cell-cell adhesion [GO:0098609]; cell-cell signaling [GO:0007267]; cellular response to interferon-gamma [GO:0071346]; cellular response to interleukin-1 [GO:0071347]; cellular response to tumor necrosis factor [GO:0071356]; chemokine-mediated signaling pathway [GO:0070098]; chemotaxis [GO:0006935]; cytokine-mediated signaling pathway [GO:0019221]; defense response [GO:0006952]; eosinophil chemotaxis [GO:0048245]; G protein-coupled receptor signaling pathway [GO:0007186]; immune response [GO:0006955]; inflammatory response [GO:0006954]; integrin activation [GO:0033622]; leukocyte adhesive activation [GO:0050902]; leukocyte chemotaxis [GO:0030595]; leukocyte migration involved in inflammatory response [GO:0002523]; lymphocyte chemotaxis [GO:0048247]; macrophage chemotaxis [GO:0048246]; microglial cell activation [GO:0001774]; microglial cell proliferation [GO:0061518]; monocyte chemotaxis [GO:0002548]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell migration [GO:0030336]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001240]; negative regulation of glutamate receptor signaling pathway [GO:1900450]; negative regulation of hippocampal neuron apoptotic process [GO:0110091]; negative regulation of interleukin-1 alpha production [GO:0032690]; negative regulation of interleukin-1 beta production [GO:0032691]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of microglial cell activation [GO:1903979]; negative regulation of neuron migration [GO:2001223]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor secretion [GO:1904468]; neuron cellular homeostasis [GO:0070050]; neuron remodeling [GO:0016322]; neutrophil chemotaxis [GO:0030593]; positive regulation of actin filament bundle assembly [GO:0032233]; positive regulation of angiogenesis [GO:0045766]; positive regulation of calcium-independent cell-cell adhesion [GO:0051041]; positive regulation of cell-matrix adhesion [GO:0001954]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]; positive regulation of I-kappaB phosphorylation [GO:1903721]; positive regulation of inflammatory response [GO:0050729]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of neuron projection development [GO:0010976]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of protein kinase B signaling [GO:0051897]; positive regulation of release of sequestered calcium ion into cytosol [GO:0051281]; positive regulation of smooth muscle cell proliferation [GO:0048661]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transforming growth factor beta1 production [GO:0032914]; regulation of lipopolysaccharide-mediated signaling pathway [GO:0031664]; regulation of neurogenesis [GO:0050767]; regulation of synaptic plasticity [GO:0048167]; response to ischemia [GO:0002931]; synapse pruning [GO:0098883]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9024663}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: Processed fractalkine: Secreted {ECO:0000269|PubMed:9024663}.


uniprotID: Q9NX94
geneSymbol: WBP1L
name: WW domain binding protein 1-like (Outcome predictor in acute leukemia 1)
length: 342
go: ENSG00000166272;
opentargets: integral component of membrane [GO:0016021]
snps: rs284860 rs284859
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NX94-1; Sequence=Displayed; Name=2; IsoId=Q9NX94-2; Sequence=VSP_041670; 


uniprotID: Q9P202
geneSymbol: WHRN
pdb: 1UEZ;1UF1;1UFX;
name: Whirlin (Autosomal recessive deafness type 31 protein)
length: 907
go: ENSG00000095397;
sequence:

opentargets:
actin filament [GO:0005884]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; growth cone [GO:0030426]; periciliary membrane compartment [GO:1990075]; photoreceptor connecting cilium [GO:0032391]; photoreceptor inner segment [GO:0001917]; plasma membrane [GO:0005886]; stereocilia ankle link [GO:0002141]; stereocilia ankle link complex [GO:0002142]; stereocilium [GO:0032420]; stereocilium tip [GO:0032426]; USH2 complex [GO:1990696]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; auditory receptor cell stereocilium organization [GO:0060088]; cerebellar Purkinje cell layer formation [GO:0021694]; establishment of protein localization [GO:0045184]; inner ear receptor cell stereocilium organization [GO:0060122]; paranodal junction maintenance [GO:1990227]; positive regulation of gene expression [GO:0010628]; retina homeostasis [GO:0001895]; sensory perception of light stimulus [GO:0050953]; sensory perception of sound [GO:0007605]

snps:
rs10817610 rs35003670 rs4978584 rs11539662 rs12339210 rs942519 rs6478078 rs2274159 rs2274158 rs942519 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9P202-1; Sequence=Displayed; Name=2; IsoId=Q9P202-2; Sequence=VSP_012218, VSP_012219; Note=May be due to an intron retention.; Name=3; IsoId=Q9P202-3; Sequence=VSP_012216; Note=No experimental confirmation available.; Name=4; IsoId=Q9P202-4; Sequence=VSP_012217, VSP_012220; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, stereocilium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Detected at the level of stereocilia in inner outer hair cells of the cochlea and vestibule. Colocalizes with the growing ends of actin filaments (By similarity). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium (CC). {ECO:0000250, ECO:0000269|PubMed:17584769}.


uniprotID: P57081
geneSymbol: WDR4
reactome: R-HSA-6782315;
name: tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 (WD repeat-containing protein 4)
length: 412
go: ENSG00000160193;
snps: rs2248490 rs15736 rs6586250
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03056, ECO:0000269|PubMed:15861136}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; tRNA methyltransferase complex [GO:0043527]; tRNA (guanine-N7)-methylation [GO:0106004]; tRNA modification [GO:0006400]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P57081-1; Sequence=Displayed; Name=2; IsoId=P57081-2; Sequence=VSP_036936; Note=No experimental confirmation available.; Name=3; IsoId=P57081-3; Sequence=VSP_036935; 


uniprotID: P23025
geneSymbol: XPA
reactome: R-HSA-5696395;R-HSA-5696400;R-HSA-6781823;R-HSA-6782135;
pdb: 1D4U;1XPA;2JNW;
name: DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)
length: 273
go: ENSG00000136936;
snps: rs10983315 rs104894131 rs746617574 rs1805160 rs3176749 rs144725456 rs3176750 rs57519506
sequence:

opentargets:
cytoplasm [GO:0005737]; intercellular bridge [GO:0045171]; nucleoplasm [GO:0005654]; nucleotide-excision repair factor 1 complex [GO:0000110]; nucleus [GO:0005634]; damaged DNA binding [GO:0003684]; metal ion binding [GO:0046872]; protein domain specific binding [GO:0019904]; protein homodimerization activity [GO:0042803]; base-excision repair [GO:0006284]; DNA repair [GO:0006281]; global genome nucleotide-excision repair [GO:0070911]; intrinsic apoptotic signaling pathway in response to DNA damage [GO:0008630]; multicellular organism growth [GO:0035264]; nucleotide-excision repair involved in interstrand cross-link repair [GO:1901255]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; nucleotide-excision repair, preincision complex stabilization [GO:0006293]; protein localization to nucleus [GO:0034504]; regulation of autophagy [GO:0010506]; response to auditory stimulus [GO:0010996]; response to oxidative stress [GO:0006979]; response to toxic substance [GO:0009636]; transcription-coupled nucleotide-excision repair [GO:0006283]; UV protection [GO:0009650]; UV-damage excision repair [GO:0070914]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1918083, ECO:0000269|PubMed:19197159, ECO:0000269|PubMed:20304803}.


uniprotID: Q5MNZ9
geneSymbol: WIPI1
reactome: R-HSA-1632852;R-HSA-381038;
length: 446
go: ENSG00000070540;
snps: rs883541 rs36084378
name:
WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1) (Atg18 protein homolog) (WD40 repeat protein interacting with phosphoinositides of 49 kDa) (WIPI 49 kDa)

sequence:

opentargets:
autophagosome membrane [GO:0000421]; clathrin-coated vesicle [GO:0030136]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; extrinsic component of membrane [GO:0019898]; Golgi membrane [GO:0000139]; phagophore assembly site [GO:0000407]; phagophore assembly site membrane [GO:0034045]; trans-Golgi network [GO:0005802]; androgen receptor binding [GO:0050681]; estrogen receptor binding [GO:0030331]; phosphatidylinositol-3,5-bisphosphate binding [GO:0080025]; phosphatidylinositol-3-phosphate binding [GO:0032266]; signaling receptor binding [GO:0005102]; autophagosome assembly [GO:0000045]; autophagy [GO:0006914]; autophagy of mitochondrion [GO:0000422]; IRE1-mediated unfolded protein response [GO:0036498]; macroautophagy [GO:0016236]; protein lipidation [GO:0006497]; protein localization to phagophore assembly site [GO:0034497]; vesicle targeting, trans-Golgi to endosome [GO:0048203]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=WIPI-1 alpha; IsoId=Q5MNZ9-1; Sequence=Displayed; Name=2; Synonyms=WIPI-1 beta; IsoId=Q5MNZ9-2; Sequence=VSP_016966; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Preautophagosomal structure membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Trans elements of the Golgi and peripheral endosomes. Dynamically cycles through these compartments and is susceptible to conditions that modulate membrane flux. Enriched in clathrin-coated vesicles. Upon starvation-induced autophagy, accumulates at subcellular structures in the cytoplasm: enlarged vesicular and lasso-like structures, and large cup-shaped structures predominantly around the nucleus. Recruitment to autophagic membranes is controlled by MTMR14. Labile microtubules specifically recruit markers of autophagosome formation like WIPI1, whereas mature autophagosomes may bind to stable microtubules.


uniprotID: A6NCI4
geneSymbol: VWA3A
name: von Willebrand factor A domain-containing protein 3A
length: 1184
go: ENSG00000175267;
opentargets: extracellular region [GO:0005576]
snps: rs1105929 rs1105929 rs16972517
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=A6NCI4-1; Sequence=Displayed; Name=2; IsoId=A6NCI4-2; Sequence=VSP_032320; Note=No experimental confirmation available.; Name=3; IsoId=A6NCI4-3; Sequence=VSP_032318; Note=No experimental confirmation available.; Name=4; IsoId=A6NCI4-4; Sequence=VSP_032319, VSP_032321; Note=No experimental confirmation available.; 


uniprotID: Q502W6
geneSymbol: VWA3B
name: von Willebrand factor A domain-containing protein 3B (VWA domain-containing protein 3B)
length: 1294
go: ENSG00000168658;
opentargets: cytoplasm [GO:0005737]
snps: rs200359284 rs2305355 rs876657414 rs7601049 rs11889349 rs6731704 rs17428626 rs7587534 rs2271038
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26157035}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q502W6-1; Sequence=Displayed; Name=2; IsoId=Q502W6-2; Sequence=VSP_033838, VSP_033839; Name=3; IsoId=Q502W6-3; Sequence=VSP_033834, VSP_033840; Name=4; IsoId=Q502W6-4; Sequence=VSP_033834, VSP_033840, VSP_033843; Name=5; IsoId=Q502W6-5; Sequence=VSP_033836, VSP_033837; Name=6; IsoId=Q502W6-6; Sequence=VSP_033844; Name=7; IsoId=Q502W6-7; Sequence=VSP_033835; Name=8; IsoId=Q502W6-8; Sequence=VSP_033841, VSP_033842; 


uniprotID: P02774
geneSymbol: GC
reactome: R-HSA-196791;
pdb: 1J78;1J7E;1KW2;1KXP;1LOT;1MA9;
length: 474
go: ENSG00000145321;
drug: DB01436;DB00169;DB04224;
snps: rs7041 rs4588 rs9016
location: SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2423133}.
name:
Vitamin D-binding protein (DBP) (VDB) (Gc protein-derived macrophage activating factor) (Gc-MAF) (GcMAF) (Gc-globulin) (Group-specific component) (Gc) (Vitamin D-binding protein-macrophage activating factor) (DBP-maf)

sequence:

opentargets:
blood microparticle [GO:0072562]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; actin binding [GO:0003779]; calcidiol binding [GO:1902118]; vitamin D binding [GO:0005499]; vitamin transmembrane transporter activity [GO:0090482]; vitamin D metabolic process [GO:0042359]; vitamin transport [GO:0051180]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P02774-1; Sequence=Displayed; Name=2; IsoId=P02774-2; Sequence=VSP_038427; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P02774-3; Sequence=VSP_044523; Note=No experimental confirmation available.; 


uniprotID: Q8IWG1
geneSymbol: WDR63
name: WD repeat-containing protein 63 (Testis development protein NYD-SP29)
length: 891
go: ENSG00000162643;
snps: rs17121745 rs709783
sequence:

opentargets:
dynein complex [GO:0030286]; dynein heavy chain binding [GO:0045504]; dynein light chain binding [GO:0045503]; microtubule-based movement [GO:0007018]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWG1-1; Sequence=Displayed; Name=2; IsoId=Q8IWG1-2; Sequence=VSP_018080; Note=No experimental confirmation available.; 


uniprotID: Q9BV38
geneSymbol: WDR18
reactome: R-HSA-6791226;
name: WD repeat-containing protein 18
length: 432
go: ENSG00000065268;
snps: rs2158367 rs35068100 rs11538683
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear pre-replicative complex [GO:0005656]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Rix1 complex [GO:0097344]; multicellular organism development [GO:0007275]; pre-replicative complex assembly involved in nuclear cell cycle DNA replication [GO:0006267]; regulation of DNA-dependent DNA replication initiation [GO:0030174]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21326211}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Cytoplasm {ECO:0000250|UniProtKB:Q4VBE8}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250|UniProtKB:Q4VBE8}.


uniprotID: P0DP72
geneSymbol: VSIG10L2
name: V-set and immunoglobulin domain-containing protein 10-like 2
length: 767
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
sequence:


uniprotID: Q562E7
geneSymbol: WDR81
name: WD repeat-containing protein 81
length: 1941
go: ENSG00000167716;
snps: rs587776906 rs3809870
sequence:

opentargets:
autophagosome membrane [GO:0000421]; cytosol [GO:0005829]; early endosome membrane [GO:0031901]; extrinsic component of endosome membrane [GO:0031313]; late endosome membrane [GO:0031902]; lysosomal membrane [GO:0005765]; mitochondrion [GO:0005739]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; phosphatidylinositol 3-kinase regulator activity [GO:0035014]; aggrephagy [GO:0035973]; early endosome to late endosome transport [GO:0045022]; mitochondrion organization [GO:0007005]; negative regulation of phosphatase activity [GO:0010923]; protein stabilization [GO:0050821]; regulation of phosphatidylinositol 3-kinase activity [GO:0043551]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q562E7-1; Sequence=Displayed; Name=2; IsoId=Q562E7-2; Sequence=VSP_044065, VSP_019955; Note=No experimental confirmation available.; Name=3; IsoId=Q562E7-3; Sequence=VSP_044065; Note=No experimental confirmation available.; Name=4; IsoId=Q562E7-4; Sequence=VSP_044067; Note=No experimental confirmation available.; Name=5; IsoId=Q562E7-5; Sequence=VSP_044064, VSP_044066; Note=No experimental confirmation available.; Name=6; IsoId=Q562E7-6; Sequence=VSP_044063; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}; Peripheral membrane protein {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989}. Late endosome membrane {ECO:0000269|PubMed:26783301, ECO:0000269|PubMed:27126989, ECO:0000269|PubMed:28404643}. Lysosome membrane {ECO:0000269|PubMed:27126989}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28404643}. Mitochondrion {ECO:0000269|PubMed:28404643}. Cytoplasm, cytosol {ECO:0000269|PubMed:27126989}.


uniprotID: Q8IZQ1
geneSymbol: WDFY3
pdb: 3WIM;
name: WD repeat and FYVE domain-containing protein 3 (Autophagy-linked FYVE protein) (Alfy)
length: 3526
go: ENSG00000163625;
snps: rs17368018
sequence:

opentargets:
autophagosome [GO:0005776]; axon [GO:0030424]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extrinsic component of autophagosome membrane [GO:0097635]; extrinsic component of membrane [GO:0019898]; inclusion body [GO:0016234]; nuclear envelope [GO:0005635]; nuclear membrane [GO:0031965]; nucleolus [GO:0005730]; nucleus [GO:0005634]; perikaryon [GO:0043204]; plasma membrane [GO:0005886]; PML body [GO:0016605]; 1-phosphatidylinositol binding [GO:0005545]; beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity [GO:0003831]; metal ion binding [GO:0046872]; aggrephagy [GO:0035973]; multicellular organism development [GO:0007275]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IZQ1-1; Sequence=Displayed; Name=2; IsoId=Q8IZQ1-2; Sequence=VSP_019475; 

location:
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}. Cytoplasm, cytosol {ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}. Nucleus, PML body {ECO:0000269|PubMed:20168092}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:15292400}; Cytoplasmic side {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q6VNB8}. Cell projection, axon {ECO:0000250|UniProtKB:Q6VNB8}. Note=Relocalization from the nucleus to the cytosol is stimulated by cellular stress, such as starvation or proteasomal inhibition. In the cytosol of starved cells, colocalizes with autophagic structures (PubMed:15292400, PubMed:20168092, PubMed:20971078, PubMed:20417604). This redistribution is dependent on p62/SQSTM1 (PubMed:20168092). When nuclear export is blocked by treatment with leptomycin B, accumulates in nuclear bodies, that completely or partially colocalize with promyelocytic leukemia (PML) bodies (PubMed:20168092). Localizes throughout neurons, including within axons. In neurons, enriched in the light membrane fraction along with the synaptosomal membrane protein synaptophysin and the membrane-bound form of LC3/MAP1LC3A/MAP1LC3B, called LC3-II, a classic marker for autophagic vesicles (By similarity). {ECO:0000250|UniProtKB:Q6VNB8, ECO:0000269|PubMed:15292400, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20417604, ECO:0000269|PubMed:20971078}.


uniprotID: Q8NI36
geneSymbol: WDR36
reactome: R-HSA-6790901;R-HSA-6791226;
name: WD repeat-containing protein 36 (T-cell activation WD repeat-containing protein) (TA-WDRP)
length: 951
go: ENSG00000134987;
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; regulation of axon extension [GO:0030516]; response to stimulus [GO:0050896]; retina homeostasis [GO:0001895]; rRNA processing [GO:0006364]; visual perception [GO:0007601]

snps:
rs145437203 rs148041801 rs35629723 rs549211166 rs62376783 rs142088179 rs11241095 rs118204022 rs771276992 rs35703638 rs17623803 rs372059163 rs116529882 rs34595252 rs11956837 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21051332, ECO:0000269|PubMed:22002106}.


uniprotID: O14905
geneSymbol: WNT9B
reactome: R-HSA-3238698;R-HSA-373080;
name: Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15)
length: 357
go: ENSG00000158955;
snps: rs4968281
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; co-receptor binding [GO:0039706]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cell-cell signaling [GO:0007267]; cellular response to retinoic acid [GO:0071300]; cellular response to starvation [GO:0009267]; collecting duct development [GO:0072044]; cornea development in camera-type eye [GO:0061303]; embryonic cranial skeleton morphogenesis [GO:0048701]; establishment of planar polarity involved in nephron morphogenesis [GO:0072046]; in utero embryonic development [GO:0001701]; kidney rudiment formation [GO:0072003]; male genitalia development [GO:0030539]; mesenchymal stem cell maintenance involved in nephron morphogenesis [GO:0072038]; mesonephric duct formation [GO:0072181]; metanephric tubule formation [GO:0072174]; midbrain dopaminergic neuron differentiation [GO:1904948]; multicellular organism development [GO:0007275]; negative regulation of stem cell population maintenance [GO:1902455]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation [GO:1905438]; positive regulation of catalytic activity [GO:0043085]; regulation of asymmetric cell division [GO:0009786]; regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [GO:0003339]; regulation of protein phosphorylation [GO:0001932]; regulation of tube size [GO:0035150]; response to retinoic acid [GO:0032526]; roof of mouth development [GO:0060021]; uterus morphogenesis [GO:0061038]; Wnt signaling pathway [GO:0016055]; Wnt signaling pathway, planar cell polarity pathway [GO:0060071]


uniprotID: P61964
geneSymbol: WDR5
reactome: R-HSA-3214841;R-HSA-3214847;R-HSA-3214858;R-HSA-5617472;R-HSA-8936459;R-HSA-8951664;
name: WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
length: 334
go: ENSG00000196363;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17355966, ECO:0000269|PubMed:20018852}.
pdb:
2CNX;2CO0;2G99;2G9A;2GNQ;2H13;2H14;2H68;2H6K;2H6N;2H6Q;2H9L;2H9M;2H9N;2H9P;2O9K;3EG6;3EMH;3MXX;3N0D;3N0E;3P4F;3PSL;3SMR;3UR4;3UVK;3UVL;3UVM;3UVN;3UVO;4A7J;4CY1;4CY2;4ERQ;4ERY;4ERZ;4ES0;4ESG;4EWR;4GM3;4GM8;4GM9;4GMB;4IA9;4O45;4QL1;4Y7R;5EAL;5EAM;5EAP;5EAR;5M23;5M25;5SXM;5VFC;6BYN;6D9X;6DAI;6DAK;6DAR;6DAS;

sequence:

opentargets:
Ada2/Gcn5/Ada3 transcription activator complex [GO:0005671]; histone acetyltransferase complex [GO:0000123]; histone methyltransferase complex [GO:0035097]; intracellular [GO:0005622]; MLL1 complex [GO:0071339]; MLL3/4 complex [GO:0044666]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Set1C/COMPASS complex [GO:0048188]; histone-lysine N-methyltransferase activity [GO:0018024]; methylated histone binding [GO:0035064]; histone H3 acetylation [GO:0043966]; histone H3-K4 methylation [GO:0051568]; histone H4-K16 acetylation [GO:0043984]; histone H4-K5 acetylation [GO:0043981]; histone H4-K8 acetylation [GO:0043982]; neuron projection development [GO:0031175]; positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [GO:0035948]; post-translational protein modification [GO:0043687]; regulation of megakaryocyte differentiation [GO:0045652]; skeletal system development [GO:0001501]


uniprotID: Q9GZT5
geneSymbol: WNT10A
reactome: R-HSA-3238698;R-HSA-373080;
name: Protein Wnt-10a
length: 417
go: ENSG00000135925;
sequence:

opentargets:
extracellular region [GO:0005576]; extracellular space [GO:0005615]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to transforming growth factor beta stimulus [GO:0071560]; epidermis morphogenesis [GO:0048730]; hair follicle development [GO:0001942]; hair follicle morphogenesis [GO:0031069]; neural crest cell differentiation [GO:0014033]; neuron differentiation [GO:0030182]; odontogenesis [GO:0042476]; positive regulation of gene expression [GO:0010628]; regulation of odontogenesis of dentin-containing tooth [GO:0042487]; sebaceous gland development [GO:0048733]; skin development [GO:0043588]; tongue development [GO:0043586]; Wnt signaling pathway [GO:0016055]

snps:
rs146460077 rs318240759 rs141074983 rs121908121 rs372993798 rs202024965 rs543063101 rs368280129 rs116998555 rs147680216 rs146902156 rs149245953 rs121908120 rs778752861 rs1057306 rs745513263 rs750190755 


uniprotID: P56705
geneSymbol: WNT4
reactome: R-HSA-201681;R-HSA-3238698;R-HSA-373080;R-HSA-3772470;R-HSA-4086400;
name: Protein Wnt-4
length: 351
go: ENSG00000162552;
snps: rs121908653 rs121908651 rs121908650 rs34228276
location: SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; Golgi lumen [GO:0005796]; plasma membrane [GO:0005886]; frizzled binding [GO:0005109]; receptor ligand activity [GO:0048018]; transcription corepressor activity [GO:0003714]; adrenal gland development [GO:0030325]; branching involved in ureteric bud morphogenesis [GO:0001658]; canonical Wnt signaling pathway [GO:0060070]; cell fate commitment [GO:0045165]; cellular response to starvation [GO:0009267]; cellular response to transforming growth factor beta stimulus [GO:0071560]; embryonic epithelial tube formation [GO:0001838]; epithelial to mesenchymal transition [GO:0001837]; female gonad development [GO:0008585]; female sex determination [GO:0030237]; hormone metabolic process [GO:0042445]; immature T cell proliferation in thymus [GO:0033080]; kidney development [GO:0001822]; liver development [GO:0001889]; male gonad development [GO:0008584]; mammary gland epithelium development [GO:0061180]; mesenchymal to epithelial transition [GO:0060231]; metanephric mesenchymal cell differentiation [GO:0072162]; metanephric nephron morphogenesis [GO:0072273]; metanephric tubule formation [GO:0072174]; negative regulation of androgen biosynthetic process [GO:2000180]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of cell differentiation [GO:0045596]; negative regulation of cell migration [GO:0030336]; negative regulation of fibroblast growth factor receptor signaling pathway [GO:0040037]; negative regulation of gene expression [GO:0010629]; negative regulation of male gonad development [GO:2000019]; negative regulation of steroid biosynthetic process [GO:0010894]; negative regulation of testicular blood vessel morphogenesis [GO:0061369]; negative regulation of testosterone biosynthetic process [GO:2000225]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of wound healing [GO:0061045]; neuron differentiation [GO:0030182]; non-canonical Wnt signaling pathway via MAPK cascade [GO:0038030]; oocyte development [GO:0048599]; paramesonephric duct development [GO:0061205]; positive regulation of aldosterone biosynthetic process [GO:0032349]; positive regulation of bone mineralization [GO:0030501]; positive regulation of collagen biosynthetic process [GO:0032967]; positive regulation of cortisol biosynthetic process [GO:2000066]; positive regulation of dermatome development [GO:0061184]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of GTPase activity [GO:0043547]; positive regulation of meiotic nuclear division [GO:0045836]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of cell-cell adhesion [GO:0022407]; renal vesicle formation [GO:0072033]; renal vesicle induction [GO:0072034]; smooth muscle cell differentiation [GO:0051145]; somatotropin secreting cell differentiation [GO:0060126]; tertiary branching involved in mammary gland duct morphogenesis [GO:0060748]; thyroid-stimulating hormone-secreting cell differentiation [GO:0060129]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P56705-1; Sequence=Displayed; Name=2; IsoId=P56705-2; Sequence=VSP_054017; Note=No experimental confirmation available.; 


uniprotID: Q14191
geneSymbol: WRN
pdb: 2AXL;2DGZ;2E1E;2E1F;2FBT;2FBV;2FBX;2FBY;2FC0;3AAF;
length: 1432
go: ENSG00000165392;
reactome:
R-HSA-3108214;R-HSA-5685938;R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;

name:
Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2)

sequence:

opentargets:
centrosome [GO:0005813]; chromosome [GO:0005694]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; neuron projection [GO:0043005]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; replication fork [GO:0005657]; site of double-strand break [GO:0035861]; 3'-5' DNA helicase activity [GO:0043138]; 3'-5' exonuclease activity [GO:0008408]; 3'-flap-structured DNA binding [GO:0070337]; 8-hydroxy-2'-deoxyguanosine DNA binding [GO:1905773]; ATP binding [GO:0005524]; ATP-dependent 3'-5' DNA helicase activity [GO:0043140]; ATP-dependent DNA helicase activity [GO:0004003]; ATPase activity [GO:0016887]; bubble DNA binding [GO:0000405]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA helicase activity [GO:0003678]; exonuclease activity [GO:0004527]; forked DNA-dependent helicase activity [GO:0061749]; four-way junction DNA binding [GO:0000400]; four-way junction helicase activity [GO:0009378]; G-quadruplex DNA binding [GO:0051880]; helicase activity [GO:0004386]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; MutLalpha complex binding [GO:0032405]; protein homodimerization activity [GO:0042803]; protein-containing complex binding [GO:0044877]; telomeric D-loop binding [GO:0061821]; telomeric G-quadruplex DNA binding [GO:0061849]; Y-form DNA binding [GO:0000403]; aging [GO:0007568]; base-excision repair [GO:0006284]; brain development [GO:0007420]; cell aging [GO:0007569]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to gamma radiation [GO:0071480]; cellular response to starvation [GO:0009267]; determination of adult lifespan [GO:0008340]; DNA duplex unwinding [GO:0032508]; DNA metabolic process [GO:0006259]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA synthesis involved in DNA repair [GO:0000731]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; G-quadruplex DNA unwinding [GO:0044806]; multicellular organism aging [GO:0010259]; positive regulation of hydrolase activity [GO:0051345]; positive regulation of strand invasion [GO:0098530]; protein localization to nucleolus [GO:1902570]; regulation of apoptotic process [GO:0042981]; regulation of growth rate [GO:0040009]; replication fork processing [GO:0031297]; replicative cell aging [GO:0001302]; response to oxidative stress [GO:0006979]; response to UV-C [GO:0010225]; t-circle formation [GO:0090656]; telomere maintenance [GO:0000723]; telomeric D-loop disassembly [GO:0061820]

snps:
rs34477820 rs2230009 rs387906337 rs267607008 rs367991517 rs148229804 rs1800390 rs4987237 rs11574222 rs4987238 rs1800391 rs11574240 rs11574250 rs11574289 rs34560788 rs3087425 rs11574323 rs1801195 rs3087414 rs11574358 rs139323683 rs746648510 rs11574395 rs1346044 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9618508}. Nucleus {ECO:0000269|PubMed:17563354, ECO:0000269|PubMed:19652551}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21639834}. Note=Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation. {ECO:0000269|PubMed:21639834}.


uniprotID: Q9Y6W5
geneSymbol: WASF2
reactome: R-HSA-2029482;R-HSA-4420097;R-HSA-5663213;
pdb: 2A40;
length: 498
go: ENSG00000158195;
name:
Wiskott-Aldrich syndrome protein family member 2 (WASP family protein member 2) (Protein WAVE-2) (Verprolin homology domain-containing protein 2)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cell-cell junction [GO:0005911]; cytosol [GO:0005829]; early endosome [GO:0005769]; extracellular exosome [GO:0070062]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; protein-containing complex [GO:0032991]; ruffle [GO:0001726]; SCAR complex [GO:0031209]; synapse [GO:0045202]; actin binding [GO:0003779]; cadherin binding [GO:0045296]; protein kinase A binding [GO:0051018]; protein-containing complex binding [GO:0044877]; SH3 domain binding [GO:0017124]; actin cytoskeleton organization [GO:0030036]; actin filament-based movement [GO:0030048]; adenylate cyclase-modulating G protein-coupled receptor signaling pathway [GO:0007188]; ameboidal-type cell migration [GO:0001667]; angiogenesis [GO:0001525]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; lamellipodium assembly [GO:0030032]; lamellipodium morphogenesis [GO:0072673]; megakaryocyte development [GO:0035855]; negative regulation of stress fiber assembly [GO:0051497]; positive regulation of lamellipodium assembly [GO:0010592]; postsynaptic actin cytoskeleton organization [GO:0098974]; Rac protein signal transduction [GO:0016601]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y6W5-1; Sequence=Displayed; Name=2; IsoId=Q9Y6W5-2; Sequence=VSP_042514, VSP_042515; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}.


uniprotID: O43542
geneSymbol: XRCC3
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;
name: DNA repair protein XRCC3 (X-ray repair cross-complementing protein 3)
length: 346
go: ENSG00000126215;
snps: rs3212057 rs861539 rs28903080 rs28903081
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; nuclear chromosome, telomeric region [GO:0000784]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; Rad51C-XRCC3 complex [GO:0033065]; replication fork [GO:0005657]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent ATPase activity [GO:0008094]; cellular response to DNA damage stimulus [GO:0006974]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via synthesis-dependent strand annealing [GO:0045003]; interstrand cross-link repair [GO:0036297]; positive regulation of mitotic cell cycle spindle assembly checkpoint [GO:0090267]; regulation of centrosome duplication [GO:0010824]; resolution of mitotic recombination intermediates [GO:0071140]; response to organic substance [GO:0010033]; t-circle formation [GO:0090656]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomere trimming [GO:0090737]; telomeric loop disassembly [GO:0090657]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.


uniprotID: Q5GFL6
geneSymbol: VWA2
length: 755
go: ENSG00000165816;
snps: rs9664945 rs597371
location: SUBCELLULAR LOCATION: Secreted.
name:
von Willebrand factor A domain-containing protein 2 (A domain-containing protein similar to matrilin and collagen) (AMACO) (Colon cancer secreted protein 2) (CCSP-2)

sequence:

opentargets:
basement membrane [GO:0005604]; extracellular exosome [GO:0070062]; extracellular matrix [GO:0031012]; extracellular space [GO:0005615]; calcium ion binding [GO:0005509]; identical protein binding [GO:0042802]; calcium-independent cell-matrix adhesion [GO:0007161]; growth plate cartilage chondrocyte morphogenesis [GO:0003429]; protein homooligomerization [GO:0051260]; regulation of insulin receptor signaling pathway [GO:0046626]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q5GFL6-1; Sequence=Displayed; Name=2; IsoId=Q5GFL6-2; Sequence=VSP_028739; Name=3; IsoId=Q5GFL6-3; Sequence=VSP_028737, VSP_028738, VSP_028739; Note=No experimental confirmation available.; 


uniprotID: Q9UPY6
geneSymbol: WASF3
reactome: R-HSA-2029482;R-HSA-4420097;R-HSA-5663213;
length: 502
go: ENSG00000132970;
snps: rs17084492
location: SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
name:
Wiskott-Aldrich syndrome protein family member 3 (WASP family protein member 3) (Protein WAVE-3) (Verprolin homology domain-containing protein 3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; lamellipodium [GO:0030027]; postsynapse [GO:0098794]; actin binding [GO:0003779]; actin filament polymerization [GO:0030041]; cytoskeleton organization [GO:0007010]; lamellipodium assembly [GO:0030032]; modification of postsynaptic actin cytoskeleton [GO:0098885]; oligodendrocyte development [GO:0014003]; positive regulation of myelination [GO:0031643]; protein-containing complex assembly [GO:0065003]; regulation of cell shape [GO:0008360]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UPY6-1; Sequence=Displayed; Name=2; IsoId=Q9UPY6-2; Sequence=VSP_054517; Note=No experimental confirmation available.; 


uniprotID: O43379
geneSymbol: WDR62
name: WD repeat-containing protein 62
length: 1518
go: ENSG00000075702;
sequence:

opentargets:
centriole [GO:0005814]; centrosome [GO:0005813]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; spindle pole [GO:0000922]; centriole replication [GO:0007099]; cerebral cortex development [GO:0021987]; mitotic spindle organization [GO:0007052]; neurogenesis [GO:0022008]

snps:
rs387907084 rs267607176 rs12327568 rs387907082 rs387907083 rs147875659 rs2285745 rs2074435 rs35811023 rs17851503 rs1008328 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O43379-1; Sequence=Displayed; Name=2; IsoId=O43379-2; Sequence=VSP_024079, VSP_024080; Note=No experimental confirmation available.; Name=3; IsoId=O43379-3; Sequence=VSP_024077, VSP_024078; Note=No experimental confirmation available.; Name=4; IsoId=O43379-4; Sequence=VSP_039906; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20729831, ECO:0000269|PubMed:21496009}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:20890279, ECO:0000269|PubMed:28089251}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:21496009, ECO:0000269|PubMed:26297806}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26297806}. Note=Shows cell cycle-dependent localization. Accumulates to the spindle pole during mitosis. Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. {ECO:0000269|PubMed:20890278, ECO:0000269|PubMed:26297806}.


uniprotID: Q96J92
geneSymbol: WNK4
reactome: R-HSA-2672351;
pdb: 2V3S;4CH9;4CHB;
length: 1243
go: ENSG00000126562;
snps: rs137853093 rs137853094 rs137853092 rs55781437 rs9896991 rs2290041 rs137853095
name:
Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4)

sequence:

opentargets:
bicellular tight junction [GO:0005923]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; ATP binding [GO:0005524]; chloride channel inhibitor activity [GO:0019869]; potassium channel inhibitor activity [GO:0019870]; protein serine/threonine kinase activity [GO:0004674]; chloride transport [GO:0006821]; distal tubule morphogenesis [GO:0072156]; intracellular signal transduction [GO:0035556]; ion homeostasis [GO:0050801]; ion transport [GO:0006811]; negative regulation of pancreatic juice secretion [GO:0090188]; negative regulation of sodium ion transport [GO:0010766]; positive regulation of ion transmembrane transporter activity [GO:0032414]; positive regulation of potassium ion import [GO:1903288]; positive regulation of sodium ion transmembrane transporter activity [GO:2000651]; protein localization [GO:0008104]; protein phosphorylation [GO:0006468]; regulation of cellular process [GO:0050794]; renal sodium ion absorption [GO:0070294]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000269|PubMed:11498583, ECO:0000305}; IsoId=Q96J92-1; Sequence=Displayed; Name=2 {ECO:0000305}; IsoId=Q96J92-2; Sequence=VSP_050648, VSP_050649, VSP_050650, VSP_050651; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000305}; IsoId=Q96J92-3; Sequence=VSP_050652, VSP_050653; Note=No experimental confirmation available. Incomplete sequence. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q80UE6}. Note=Present exclusively in intercellular junctions in the distal convoluted tubule and in both the cytoplasm and intercellular junctions in the cortical collecting duct. WNK4 is part of the tight junction complex. {ECO:0000250|UniProtKB:Q80UE6}.


uniprotID: Q8IZH2
geneSymbol: XRN1
reactome: R-HSA-430039;R-HSA-450385;R-HSA-450513;
name: 5'-3' exoribonuclease 1 (EC 3.1.13.-) (Strand-exchange protein 1 homolog)
length: 1706
go: ENSG00000114127;
snps: rs35214510 rs35902661
sequence:

opentargets:
cytosol [GO:0005829]; dendrite [GO:0030425]; membrane [GO:0016020]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; P-body [GO:0000932]; plasma membrane [GO:0005886]; synapse [GO:0045202]; 5'-3' exoribonuclease activity [GO:0004534]; G-quadruplex DNA binding [GO:0051880]; G-quadruplex RNA binding [GO:0002151]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]; cellular response to cycloheximide [GO:0071409]; cellular response to puromycin [GO:1905795]; histone mRNA catabolic process [GO:0071044]; negative regulation of telomere maintenance via telomerase [GO:0032211]; negative regulation of translation [GO:0017148]; nuclear mRNA surveillance [GO:0071028]; nuclear-transcribed mRNA catabolic process [GO:0000956]; regulation of mRNA stability [GO:0043488]; response to testosterone [GO:0033574]; RNA phosphodiester bond hydrolysis, exonucleolytic [GO:0090503]; rRNA catabolic process [GO:0016075]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8IZH2-1; Sequence=Displayed; Name=2; IsoId=Q8IZH2-2; Sequence=VSP_016694, VSP_016695; Name=3; IsoId=Q8IZH2-3; Sequence=VSP_016692, VSP_016693; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:14580940, ECO:0000269|PubMed:9802570}. Note=Discrete foci at the inner surface of the cell membrane.


uniprotID: O75695
geneSymbol: RP2
reactome: R-HSA-5624138;
pdb: 2BX6;3BH6;3BH7;
name: Protein XRP2
length: 350
go: ENSG00000102218;
snps: rs28933687 rs28933687 rs3126141 rs1805147 rs1805148
sequence:

opentargets:
centriole [GO:0005814]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; extracellular exosome [GO:0070062]; Golgi apparatus [GO:0005794]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; periciliary membrane compartment [GO:1990075]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activator activity [GO:0005096]; unfolded protein binding [GO:0051082]; cell morphogenesis [GO:0000902]; post-Golgi vesicle-mediated transport [GO:0006892]; protein folding [GO:0006457]; protein transport [GO:0015031]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10942419, ECO:0000269|PubMed:12417528}; Lipid-anchor {ECO:0000269|PubMed:10942419}; Cytoplasmic side {ECO:0000269|PubMed:10942419}. Cell projection, cilium {ECO:0000269|PubMed:20106869}. Note=Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. {ECO:0000269|PubMed:12417528}.


uniprotID: Q9BRX9
geneSymbol: WDR83
reactome: R-HSA-5674135;
length: 315
go: ENSG00000123154;
snps: rs34373915 rs35092999
name:
WD repeat domain-containing protein 83 (Mitogen-activated protein kinase organizer 1) (MAPK organizer 1)

sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; endosome membrane [GO:0010008]; spliceosomal complex [GO:0005681]; MAPK cascade [GO:0000165]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing, via transesterification reactions [GO:0000375]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.


uniprotID: Q9Y334
geneSymbol: VWA7
name: von Willebrand factor A domain-containing protein 7 (Protein G7c)
length: 891
go: ENSG00000204396;
opentargets: extracellular region [GO:0005576]
snps: rs17207531 rs11966331 rs28400004 rs28400002 rs28400001 rs3101017
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y334-1; Sequence=Displayed; Name=2; IsoId=Q9Y334-2; Sequence=VSP_026494, VSP_026495; 


uniprotID: Q5JSH3
geneSymbol: WDR44
name: WD repeat-containing protein 44 (Rabphilin-11)
length: 913
go: ENSG00000131725;
snps: rs17271416 rs17855531
sequence:

opentargets:
cytosol [GO:0005829]; endosome membrane [GO:0010008]; Golgi apparatus [GO:0005794]; perinuclear region of cytoplasm [GO:0048471]; Rab GTPase binding [GO:0017137]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5JSH3-1; Sequence=Displayed; Name=2; IsoId=Q5JSH3-2; Sequence=VSP_021809; Note=No experimental confirmation available.; Name=3; IsoId=Q5JSH3-3; Sequence=VSP_021807, VSP_021808, VSP_021810; Note=No experimental confirmation available.; Name=4; IsoId=Q5JSH3-4; Sequence=VSP_046637, VSP_046638; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, perinuclear region. Endosome membrane. Golgi apparatus, trans-Golgi network. Note=Colocalized with RAB11 along microtubules oriented toward lamellipodia. {ECO:0000250}.


uniprotID: Q8NBI6
geneSymbol: XXYLT1
length: 393
go: ENSG00000173950;
name:
Xyloside xylosyltransferase 1 (EC 2.4.2.n3) (UDP-xylose:alpha-xyloside alpha-1,3-xylosyltransferase)

sequence:

opentargets:
integral component of endoplasmic reticulum membrane [GO:0030176]; magnesium ion binding [GO:0000287]; manganese ion binding [GO:0030145]; UDP-xylosyltransferase activity [GO:0035252]; O-glycan processing [GO:0016266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NBI6-1; Sequence=Displayed; Name=2; IsoId=Q8NBI6-2; Sequence=VSP_018315, VSP_018317; Note=No experimental confirmation available.; Name=3; IsoId=Q8NBI6-3; Sequence=VSP_018315, VSP_018316, VSP_018318; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22117070}; Single-pass type II membrane protein {ECO:0000269|PubMed:22117070}.


uniprotID: Q6P2D8
geneSymbol: XRRA1
name: X-ray radiation resistance-associated protein 1
length: 792
go: ENSG00000166435;
snps: rs4944960 rs12291445
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; response to X-ray [GO:0010165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1 {ECO:0000305}; IsoId=Q6P2D8-1; Sequence=Displayed; Note=Gene model based on mouse cDNA data. No experimental confirmation available. {ECO:0000305}; Name=2 {ECO:0000269|PubMed:15489334}; IsoId=Q6P2D8-2; Sequence=VSP_052670, VSP_052673, VSP_052674; Note=No experimental confirmation available. {ECO:0000305}; Name=3 {ECO:0000269|PubMed:12908878}; IsoId=Q6P2D8-3; Sequence=VSP_052672; Name=4; IsoId=Q6P2D8-4; Sequence=VSP_052671; Note=No experimental confirmation available. {ECO:0000305}; Name=5; IsoId=Q6P2D8-5; Sequence=VSP_044988, VSP_044989; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12908878}. Nucleus {ECO:0000269|PubMed:12908878}.


uniprotID: Q702N8
geneSymbol: XIRP1
name: Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1)
length: 1843
go: ENSG00000168334;
sequence:

opentargets:
cell junction [GO:0030054]; actin filament binding [GO:0051015]; RNA binding [GO:0003723]; actin filament organization [GO:0007015]; heart development [GO:0007507]; negative regulation of protein binding [GO:0032091]

snps:
rs2271488 rs6805248 rs34121641 rs60540208 rs9823779 rs11711871 rs35649793 rs35795536 rs3732383 rs34810344 rs768911526 rs34053674 rs9827576 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=A; IsoId=Q702N8-1; Sequence=Displayed; Name=B; IsoId=Q702N8-2; Sequence=VSP_030844, VSP_030845; Name=C; IsoId=Q702N8-3; Sequence=VSP_030843; 

location:
SUBCELLULAR LOCATION: Cell junction {ECO:0000269|PubMed:15454575}. Note=Colocalizes with actin stress fibers.


uniprotID: Q9UIA9
geneSymbol: XPO7
name: Exportin-7 (Exp7) (Ran-binding protein 16)
length: 1087
go: ENSG00000130227;
snps: rs17856894 rs17856895
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; nuclear export signal receptor activity [GO:0005049]; Ran GTPase binding [GO:0008536]; mRNA transport [GO:0051028]; protein export from nucleus [GO:0006611]

location:
SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000305}. Nucleus, nuclear pore complex {ECO:0000305}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000305}.


uniprotID: O75191
geneSymbol: XYLB
reactome: R-HSA-5661270;
pdb: 4BC2;4BC3;4BC4;4BC5;
name: Xylulose kinase (Xylulokinase) (EC 2.7.1.17)
length: 536
go: ENSG00000093217;
snps: rs17118 rs2234610 rs151611 rs196380 rs2234622
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; ATP binding [GO:0005524]; xylulokinase activity [GO:0004856]; carbohydrate metabolic process [GO:0005975]; D-xylose metabolic process [GO:0042732]; generation of precursor metabolites and energy [GO:0006091]; glucuronate catabolic process to xylulose 5-phosphate [GO:0019640]; phosphorylation [GO:0016310]; xylulose catabolic process [GO:0005998]; xylulose metabolic process [GO:0005997]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75191-1; Sequence=Displayed; Name=2; IsoId=O75191-2; Sequence=VSP_055522; Note=No experimental confirmation available.; 


uniprotID: Q96P53
geneSymbol: WDFY2
length: 400
go: ENSG00000139668;
name:
WD repeat and FYVE domain-containing protein 2 (Propeller-FYVE protein) (Prof) (WD40- and FYVE domain-containing protein 2) (Zinc finger FYVE domain-containing protein 22)

sequence:

opentargets:
early endosome [GO:0005769]; vesicle [GO:0031982]; metal ion binding [GO:0046872]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of protein phosphorylation [GO:0001934]

location:
SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:16873553}. Early endosome {ECO:0000269|PubMed:16792529}. Cytoplasm {ECO:0000250|UniProtKB:Q8BUB4}. Note=Localizes to intracellular vesicles (PubMed:16792529). Colocalizes with VAMP2 and PRKCZ in intracellular vesicles (PubMed:17313651). Colocalizes with AKT2 in early endosomes (By similarity). {ECO:0000250|UniProtKB:Q8BUB4, ECO:0000269|PubMed:16792529, ECO:0000269|PubMed:17313651}.


uniprotID: Q9NZC7
geneSymbol: WWOX
reactome: R-HSA-1251985;R-HSA-8866904;R-HSA-8866907;
pdb: 1WMV;
length: 414
go: ENSG00000186153;
name:
WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase) (Short chain dehydrogenase/reductase family 41C member 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; Golgi apparatus [GO:0005794]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; RNA polymerase II transcription factor complex [GO:0090575]; coenzyme binding [GO:0050662]; cofactor binding [GO:0048037]; enzyme binding [GO:0019899]; oxidoreductase activity [GO:0016491]; protein dimerization activity [GO:0046983]; transcription coactivator activity [GO:0003713]; cellular response to transforming growth factor beta stimulus [GO:0071560]; extrinsic apoptotic signaling pathway [GO:0097191]; intrinsic apoptotic signaling pathway by p53 class mediator [GO:0072332]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of Wnt signaling pathway [GO:0030178]; osteoblast differentiation [GO:0001649]; oxidation-reduction process [GO:0055114]; positive regulation of extrinsic apoptotic signaling pathway [GO:2001238]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of transcription by RNA polymerase II [GO:0045944]; skeletal system morphogenesis [GO:0048705]; steroid metabolic process [GO:0008202]; Wnt signaling pathway [GO:0016055]

snps:
rs730880292 rs587777128 rs144601717 rs114755364 rs141361080 rs11545029 rs7201683 rs186745328 rs3764340 rs119487098 rs73572838 rs587777127 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=FOR II, FOR2, WWOXv1, WWOX v8; IsoId=Q9NZC7-1; Sequence=Displayed; Name=2; Synonyms=FOR I, FOR1, WOX2, WWOXv2; IsoId=Q9NZC7-2; Sequence=VSP_016367, VSP_016369; Name=3; Synonyms=FOR III, FOR3, WOX3; IsoId=Q9NZC7-3; Sequence=VSP_016364, VSP_016365; Name=4; Synonyms=FOR IV; IsoId=Q9NZC7-4; Sequence=VSP_016358, VSP_016359; Name=5; Synonyms=WWOXdelta6-8, WWOXv4; IsoId=Q9NZC7-5; Sequence=VSP_016363; Name=6; Synonyms=WWOXdelta5-8, WWOXv3; IsoId=Q9NZC7-6; Sequence=VSP_016360; Name=7; IsoId=Q9NZC7-7; Sequence=VSP_016362, VSP_016366; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691, ECO:0000269|PubMed:19465938}. Nucleus {ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:15064722, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691}. Mitochondrion {ECO:0000269|PubMed:14695174}. Golgi apparatus {ECO:0000305}. Note=Partially localizes to the mitochondria (PubMed:14695174). Translocates to the nucleus upon genotoxic stress or TNF stimulation (By similarity). Translocates to the nucleus in response to TGFB1 (PubMed:19366691). Isoform 5 and isoform 6 may localize in the nucleus. {ECO:0000250, ECO:0000269|PubMed:14695174, ECO:0000269|PubMed:19366691}.


uniprotID: Q6P2C0
geneSymbol: WDR93
name: WD repeat-containing protein 93
length: 686
go: ENSG00000140527;
snps: rs4287542 rs7163367 rs7178234
sequence:

opentargets:
mitochondrial respiratory chain complex I [GO:0005747]; NADH dehydrogenase (ubiquinone) activity [GO:0008137]; electron transport chain [GO:0022900]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P2C0-1; Sequence=Displayed; Name=2; IsoId=Q6P2C0-2; Sequence=VSP_031512; Note=No experimental confirmation available.; 


uniprotID: B1ANS9
geneSymbol: WDR64
name: WD repeat-containing protein 64
length: 1081
go: ENSG00000162843;
snps: rs12095445 rs12074374
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=B1ANS9-1; Sequence=Displayed; Name=2; IsoId=B1ANS9-2; Sequence=VSP_033509; 


uniprotID: Q9GZV5
geneSymbol: WWTR1
reactome: R-HSA-2028269;R-HSA-2032785;R-HSA-2173796;R-HSA-5578768;R-HSA-8940973;R-HSA-8951671;
pdb: 5N5R;5N5T;5N5W;5N75;
length: 400
go: ENSG00000018408;
name:
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; protein homodimerization activity [GO:0042803]; transcription coactivator activity [GO:0003713]; transcription corepressor activity [GO:0003714]; cilium assembly [GO:0060271]; glomerulus development [GO:0032835]; heart process [GO:0003015]; hippo signaling [GO:0035329]; kidney morphogenesis [GO:0060993]; mesenchymal cell differentiation [GO:0048762]; multicellular organism growth [GO:0035264]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of transcription by RNA polymerase II [GO:0000122]; osteoblast differentiation [GO:0001649]; positive regulation of cell proliferation [GO:0008284]; positive regulation of epithelial to mesenchymal transition [GO:0010718]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein ubiquitination [GO:0016567]; regulation of metanephric nephron tubule epithelial cell differentiation [GO:0072307]; regulation of SMAD protein signal transduction [GO:0060390]; regulation of transcription, DNA-templated [GO:0006355]; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [GO:0031146]; stem cell division [GO:0017145]; tissue homeostasis [GO:0001894]; transcription initiation from RNA polymerase II promoter [GO:0006367]

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Concentrates along specific portions of the plasma membrane, and accumulates in punctate nuclear bodies. When phosphorylated, is retained in cytoplasm by YWHAZ. Can be retained in the nucleus by MED15.


uniprotID: Q9NW82
geneSymbol: WDR70
name: WD repeat-containing protein 70
length: 654
go: ENSG00000082068;
sequence:

opentargets:
nucleus [GO:0005634]; site of double-strand break [GO:0035861]; enzyme binding [GO:0019899]; regulation of DNA double-strand break processing [GO:1903775]; regulation of histone H2B conserved C-terminal lysine ubiquitination [GO:2001173]


uniprotID: Q8IWA0
geneSymbol: WDR75
reactome: R-HSA-6790901;R-HSA-6791226;
name: WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)
length: 830
go: ENSG00000115368;
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA binding [GO:0003723]; positive regulation of rRNA processing [GO:2000234]; positive regulation of transcription by RNA polymerase I [GO:0045943]; rRNA processing [GO:0006364]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:22916032}.


uniprotID: P13010
geneSymbol: XRCC5
reactome: R-HSA-164843;R-HSA-1834949;R-HSA-3270619;R-HSA-5693571;R-HSA-6798695;
pdb: 1JEQ;1JEY;1Q2Z;1RW2;3RZ9;5Y3R;
length: 732
go: ENSG00000079246;
snps: rs1805380 rs2287558
name:
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))

sequence:

opentargets:
cytosol [GO:0005829]; extracellular region [GO:0005576]; Ku70:Ku80 complex [GO:0043564]; membrane [GO:0016020]; nonhomologous end joining complex [GO:0070419]; nuclear chromosome, telomeric region [GO:0000784]; nuclear telomere cap complex [GO:0000783]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; protein-DNA complex [GO:0032993]; ribonucleoprotein complex [GO:1990904]; secretory granule lumen [GO:0034774]; site of DNA damage [GO:0090734]; ATP binding [GO:0005524]; ATP-dependent DNA helicase activity [GO:0004003]; damaged DNA binding [GO:0003684]; DNA binding [GO:0003677]; double-stranded DNA binding [GO:0003690]; enzyme activator activity [GO:0008047]; protein C-terminus binding [GO:0008022]; protein-containing complex binding [GO:0044877]; RNA binding [GO:0003723]; telomeric DNA binding [GO:0042162]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin protein ligase binding [GO:0031625]; activation of innate immune response [GO:0002218]; brain development [GO:0007420]; cell proliferation [GO:0008283]; cellular hyperosmotic salinity response [GO:0071475]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to fatty acid [GO:0071398]; cellular response to gamma radiation [GO:0071480]; cellular response to leukemia inhibitory factor [GO:1990830]; cellular response to X-ray [GO:0071481]; DNA recombination [GO:0006310]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; establishment of integrated proviral latency [GO:0075713]; hematopoietic stem cell differentiation [GO:0060218]; innate immune response [GO:0045087]; negative regulation of t-circle formation [GO:1904430]; negative regulation of transcription, DNA-templated [GO:0045892]; neutrophil degranulation [GO:0043312]; positive regulation of catalytic activity [GO:0043085]; positive regulation of neurogenesis [GO:0050769]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of telomerase activity [GO:0051973]; positive regulation of telomere maintenance via telomerase [GO:0032212]; positive regulation of type I interferon production [GO:0032481]; protein localization to chromosome, telomeric region [GO:0070198]; regulation of smooth muscle cell proliferation [GO:0048660]; regulation of telomere maintenance [GO:0032204]; response to drug [GO:0042493]; telomere maintenance [GO:0000723]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22442688}. Nucleus, nucleolus {ECO:0000269|PubMed:22002106}. Chromosome {ECO:0000269|PubMed:22442688}.


uniprotID: Q9C0E2
geneSymbol: XPO4
name: Exportin-4 (Exp4)
length: 1151
go: ENSG00000132953;
snps: rs17320607 rs9552285
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nuclear pore [GO:0005643]; nucleoplasm [GO:0005654]; nuclear export signal receptor activity [GO:0005049]; positive regulation of protein export from nucleus [GO:0046827]; protein export from nucleus [GO:0006611]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16449645}. Nucleus {ECO:0000269|PubMed:16449645}. Note=Shuttles between the nucleus and the cytoplasm.


uniprotID: Q9HD64
geneSymbol: XAGE1A; XAGE1B; XAGE1C; XAGE1D; XAGE1E
sequence: MESPKKKNQQLKVGILHLGSRQKKIRIQLRSQCATWKVICKSCISQTPGINLDLGSGVKVKIIPKEEHCKMPEAGEEQPQV
length: 81
go: ENSG00000204382;
name:
X antigen family member 1 (XAGE-1) (Cancer/testis antigen 12.1) (CT12.1) (G antigen family D member 2)

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=B; Synonyms=XAGE-1a, XAGE-1b; IsoId=Q9HD64-2; Sequence=Displayed; Note=XAGE-1a and XAGE-1b mRNAs are produced by alternative promoter usage. However, for both isoforms, the translation initiator codon remains the same, generating an identical protein. XAGE-1b is the predominant transcript, compared to XAGE-1a.; Name=D; Synonyms=XAGE-1d; IsoId=Q9HD64-4; Sequence=VSP_001596; 


uniprotID: Q6ZMY6
geneSymbol: WDR88
name: WD repeat-containing protein 88 (PQQ repeat and WD repeat-containing protein)
length: 472
go: ENSG00000166359;
snps: rs11881580
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZMY6-1; Sequence=Displayed; Name=2; IsoId=Q6ZMY6-2; Sequence=VSP_024873; Note=No experimental confirmation available.; 


uniprotID: Q96FK6
geneSymbol: WDR89
name: WD repeat-containing protein 89
length: 387
go: ENSG00000140006;
sequence:


uniprotID: Q9BZH6
geneSymbol: WDR11
length: 1224
go: ENSG00000120008;
snps: rs201051480 rs318240760 rs144440500 rs318240761 rs144531702 rs139007744
name:
WD repeat-containing protein 11 (Bromodomain and WD repeat-containing protein 2) (WD repeat-containing protein 15)

sequence:

opentargets:
axoneme [GO:0005930]; ciliary basal body [GO:0036064]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; lysosomal membrane [GO:0005765]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleus [GO:0005634]; trans-Golgi network [GO:0005802]; cilium assembly [GO:0060271]; head development [GO:0060322]; heart development [GO:0007507]; intracellular protein transport [GO:0006886]; multicellular organism growth [GO:0035264]; regulation of smoothened signaling pathway [GO:0008589]; vesicle tethering to Golgi [GO:0099041]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29263200}. Cytoplasm {ECO:0000269|PubMed:20887964}. Nucleus {ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29263200}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:29263200}. Cytoplasmic vesicle {ECO:0000269|PubMed:29426865}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29426865}. Note=Shuttles from the cilium to the nucleus in response to Hh signaling (PubMed:29263200). Might be shuttling between the nucleus and the cytoplasm (PubMed:20887964). {ECO:0000269|PubMed:20887964, ECO:0000269|PubMed:29263200}.


uniprotID: Q06250
geneSymbol: WT1-AS
sequence: MQRRGQPLENHVALIHWQSAGIPASKVHNYCNMKKSRLGRSRAVRISQPLLSPRRCPLHLTERGAGLLQPQPQGPVRTPGPPSGSHPAAADN
length: 92
snps: rs6508 rs3087923
name:
Putative Wilms tumor upstream neighbor 1 gene protein (WIT-1) (Wilms tumor-associated antisense RNA)


uniprotID: Q9H0D6
geneSymbol: XRN2
reactome: R-HSA-390471;R-HSA-6791226;
name: 5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein)
length: 950
go: ENSG00000088930;
snps: rs6137324 rs6047420
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

opentargets:
aggresome [GO:0016235]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3'-5'-exoribonuclease activity [GO:0000175]; 5'-3' exonuclease activity [GO:0008409]; 5'-3' exoribonuclease activity [GO:0004534]; metal ion binding [GO:0046872]; nuclease activity [GO:0004518]; RNA binding [GO:0003723]; transcription termination site sequence-specific DNA binding [GO:0001147]; DNA catabolic process, exonucleolytic [GO:0000738]; DNA-templated transcription, termination [GO:0006353]; hippocampus development [GO:0021766]; mRNA processing [GO:0006397]; neuron differentiation [GO:0030182]; retina development in camera-type eye [GO:0060041]; RNA catabolic process [GO:0006401]; RNA metabolic process [GO:0016070]; RNA processing [GO:0006396]; rRNA processing [GO:0006364]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=XRN2a; IsoId=Q9H0D6-1; Sequence=Displayed; Name=2; Synonyms=XRN2b; IsoId=Q9H0D6-2; Sequence=VSP_020596; Note=No experimental confirmation available.; 


uniprotID: O95070
geneSymbol: YIF1A
reactome: R-HSA-381038;
name: Protein YIF1A (54TMp) (YIP1-interacting factor homolog A)
length: 293
go: ENSG00000174851;
sequence:

opentargets:
COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; integral component of Golgi membrane [GO:0030173]; ER to Golgi vesicle-mediated transport [GO:0006888]; IRE1-mediated unfolded protein response [GO:0036498]; protein transport [GO:0015031]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:15308636, ECO:0000269|PubMed:15990086}; Multi-pass membrane protein {ECO:0000255}. Note=Cycles between the endoplasmic reticulum and the endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000269|PubMed:15308636}.


uniprotID: A6XGL0
geneSymbol: YJEFN3
name: YjeF N-terminal domain-containing protein 3 (YjeF_N3) (hYjeF_N3)
length: 299
go: ENSG00000250067;
snps: rs58031491
sequence:

opentargets:
mitochondrion [GO:0005739]; NADHX epimerase activity [GO:0052856]; NADPHX epimerase activity [GO:0052857]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6XGL0-1; Sequence=Displayed; Name=2; IsoId=A6XGL0-2; Sequence=VSP_035170; Note=No experimental confirmation available.; 


uniprotID: Q6ZUT4
name: Putative uncharacterized protein FLJ43343
length: 128
sequence:
MARVHIWPQHTAVNPRLLENQARAMIHHHLMAATPAVFLVSSGPDGSQAKAAAASYLAEPPGSPTPGPFSYTKASVVLFLPNPRPNIFKLHSKEQLAECHQYLQSNMRWDFSFAIKTRMLFLPCSDNV


uniprotID: Q92536
geneSymbol: SLC7A6
reactome: R-HSA-210991;R-HSA-352230;
length: 515
go: ENSG00000103064;
name:
Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2)

sequence:

opentargets:
basolateral plasma membrane [GO:0016323]; integral component of plasma membrane [GO:0005887]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; amino acid transmembrane transporter activity [GO:0015171]; antiporter activity [GO:0015297]; L-amino acid transmembrane transporter activity [GO:0015179]; cellular amino acid metabolic process [GO:0006520]; leukocyte migration [GO:0050900]; protein-containing complex assembly [GO:0065003]

location:
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}; Multi-pass membrane protein {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}.


uniprotID: Q92618
geneSymbol: ZNF516
name: Zinc finger protein 516
length: 1163
go: ENSG00000101493;
snps: rs3752097 rs12961584
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7TSH3}.
sequence:

opentargets:
nucleus [GO:0005634]; activating transcription factor binding [GO:0033613]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter sequence-specific DNA binding [GO:0000987]; adipose tissue development [GO:0060612]; brown fat cell differentiation [GO:0050873]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of transcription, DNA-templated [GO:0045893]; response to cold [GO:0009409]


uniprotID: Q7Z570
geneSymbol: ZNF804A
name: Zinc finger protein 804A
length: 1209
go: ENSG00000170396;
snps: rs12476147 rs35676856 rs4667001 rs35925696 rs1366842 rs12477430 rs3731834 rs12105159
sequence:

opentargets:
cytoplasm [GO:0005737]; dendritic microtubule [GO:1901588]; dendritic shaft [GO:0043198]; dendritic spine [GO:0043197]; growth cone [GO:0030426]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; postsynapse [GO:0098794]; presynapse [GO:0098793]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; positive regulation of dendritic spine maintenance [GO:1902952]; positive regulation of gene expression [GO:0010628]; positive regulation of neuron projection development [GO:0010976]; regulation of neuron projection development [GO:0010975]


uniprotID: Q9HCE3
geneSymbol: ZNF532
name: Zinc finger protein 532
length: 1301
go: ENSG00000074657;
snps: rs3737506 rs771503724
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O43296
geneSymbol: ZNF264
reactome: R-HSA-212436;
name: Zinc finger protein 264
length: 627
go: ENSG00000083844;
snps: rs2074858 rs917340
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8TCH9
name: Putative uncharacterized protein FLJ23865
length: 128
sequence:
MPSTEGFGGLDRLVLPPPPQVLPLLSPARGRIQFSGRKSTGSWVTQMENLLLAQPLPDDCEILCGWRSLLHLTFLIGFAPHFPHWFCNHHCHQHPPSHLTEVLQSSGELAHQLAPSRCSMRAEGTHRG


uniprotID: A6NJL1
geneSymbol: ZSCAN5B
name: Zinc finger and SCAN domain-containing protein 5B
length: 495
go: ENSG00000197213;
snps: rs527025 rs4801296 rs10425951 rs892183 rs16987048
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:


uniprotID: Q5BKY6
name: Putative uncharacterized protein DKFZp434K191
length: 102
sequence:
MKKRHREGCDMPGPWSTLRSHRGHHCPHLHPVLRRPTLTDVEGCLQCLDVCGHPRHAVDAHLLHASALDLLHALAHDVGHLGPLSPAGGGNVLSVLTALLGP


uniprotID: P98182
geneSymbol: ZNF200
reactome: R-HSA-212436;
name: Zinc finger protein 200
length: 395
go: ENSG00000010539;
snps: rs9302870
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P98182-1; Sequence=Displayed; Name=2; IsoId=P98182-2; Sequence=VSP_036037; Name=3; IsoId=P98182-3; Sequence=VSP_046734; 


uniprotID: Q8N972
geneSymbol: ZNF709
reactome: R-HSA-212436;
name: Zinc finger protein 709
length: 641
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription regulatory region sequence-specific DNA binding [GO:0000976]


uniprotID: Q9BYN7
geneSymbol: ZNF341
name: Zinc finger protein 341
length: 854
go: ENSG00000131061;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BYN7-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9BYN7-2; Sequence=VSP_027218; Note=Gene prediction based on EST data.; 


uniprotID: Q6P9A1
geneSymbol: ZNF530
reactome: R-HSA-212436;
name: Zinc finger protein 530
length: 599
go: ENSG00000183647;
snps: rs9677004 rs2360543 rs17855076 rs11883343 rs9676259
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q96BR6
geneSymbol: ZNF669
reactome: R-HSA-212436;
name: Zinc finger protein 669
length: 464
go: ENSG00000188295;
snps: rs4925692 rs7533935
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96BR6-1; Sequence=Displayed; Name=2; IsoId=Q96BR6-2; Sequence=VSP_047204; Note=No experimental confirmation available.; 


uniprotID: O75800
geneSymbol: ZMYND10
pdb: 2D8Q;2DAN;
name: Zinc finger MYND domain-containing protein 10 (Protein BLu)
length: 440
go: ENSG00000004838;
snps: rs138815960 rs587621539 rs200913791 rs142613783 rs753061612 rs182064110
sequence:

opentargets:
apical plasma membrane [GO:0016324]; centriolar satellite [GO:0034451]; cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; inner dynein arm assembly [GO:0036159]; motile cilium assembly [GO:0044458]; outer dynein arm assembly [GO:0036158]; positive regulation of motile cilium assembly [GO:1905505]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Lung; IsoId=O75800-1; Sequence=Displayed; Name=2; Synonyms=Testis; IsoId=O75800-2; Sequence=VSP_003328; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6AXZ5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q6AXZ5}. Apical cell membrane {ECO:0000250|UniProtKB:Q99ML0}. Note=Localizes to sites proximal to the axoneme. {ECO:0000250}.


uniprotID: Q9H5H4
geneSymbol: ZNF768
name: Zinc finger protein 768
length: 540
go: ENSG00000169957;
snps: rs10871453 rs3751848
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; transcription by RNA polymerase II [GO:0006366]


uniprotID: Q6UXV3
name: Uncharacterized protein UNQ6126/PRO20091
length: 157
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MLPEQGPQPSTMPLWCLLAACTSLPRQAATMLEEAASPNEAVHASTSGSGALTDQTFTDLSAAEASSEEVPDFMEVPHSVHHKINCFFYLEKQLCQLPSPLCLSSLLTLKLKTTVPAPGRWWSFQPHKAFPLLVGTPGSWQSTIDPAWAAPSQPSPG


uniprotID: P35789
geneSymbol: ZNF93
name: Zinc finger protein 93 (Zinc finger protein 505) (Zinc finger protein HTF34)
length: 620
go: ENSG00000184635;
snps: rs12151060
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; transcription regulatory region sequence-specific DNA binding [GO:0000976]; zinc ion binding [GO:0008270]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transposon integration [GO:0070895]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P35789-1; Sequence=Displayed; Name=2; IsoId=P35789-2; Sequence=VSP_016988; Note=No experimental confirmation available.; Name=3; IsoId=P35789-3; Sequence=VSP_016989; Note=No experimental confirmation available.; 


uniprotID: P60852
geneSymbol: ZP1
reactome: R-HSA-1300644;
length: 638
go: ENSG00000149506;
snps: rs489172
name:
Zona pellucida sperm-binding protein 1 (Zona pellucida glycoprotein 1) (Zp-1) [Cleaved into: Processed zona pellucida sperm-binding protein 1]

sequence:

opentargets:
collagen-containing extracellular matrix [GO:0062023]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; binding of sperm to zona pellucida [GO:0007339]

location:
SUBCELLULAR LOCATION: Processed zona pellucida sperm-binding protein 1: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:I6M4H4}. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000305}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48829}; Single-pass type I membrane protein {ECO:0000255}.


uniprotID: Q9H7M6
geneSymbol: ZSWIM4
name: Zinc finger SWIM domain-containing protein 4
length: 989
go: ENSG00000132003;
sequence:

opentargets:
Cul2-RING ubiquitin ligase complex [GO:0031462]; zinc ion binding [GO:0008270]; regulation of axon guidance [GO:1902667]


uniprotID: Q9BX82
geneSymbol: ZNF471
reactome: R-HSA-212436;
name: Zinc finger protein 471 (EZFIT-related protein 1)
length: 626
go: ENSG00000196263;
snps: rs11667052 rs45487092 rs3752176 rs16987303
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BX82-1; Sequence=Displayed; Name=2; IsoId=Q9BX82-2; Sequence=VSP_055955, VSP_055956; Note=No experimental confirmation available.; 


uniprotID: Q7Z739
geneSymbol: YTHDF3
name: YTH domain-containing family protein 3
length: 585
go: ENSG00000185728;
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:28106072}.
sequence:

opentargets:
cytosol [GO:0005829]; N6-methyladenosine-containing RNA binding [GO:1990247]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; mRNA destabilization [GO:0061157]; positive regulation of translation [GO:0045727]; positive regulation of translational initiation [GO:0045948]


uniprotID: Q9Y2K1
geneSymbol: ZBTB1
name: Zinc finger and BTB domain-containing protein 1
length: 713
go: ENSG00000126804;
sequence:

opentargets:
nuclear body [GO:0016604]; nuclear membrane [GO:0031965]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; B cell differentiation [GO:0030183]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to UV [GO:0034644]; chromatin remodeling [GO:0006338]; DNA repair [GO:0006281]; innate immune response [GO:0045087]; mRNA transcription by RNA polymerase II [GO:0042789]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of natural killer cell differentiation [GO:0032825]; positive regulation of pro-T cell differentiation [GO:2000176]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of T cell mediated immunity [GO:0002711]; protein homooligomerization [GO:0051260]; T cell differentiation in thymus [GO:0033077]; thymus development [GO:0048538]; translesion synthesis [GO:0019985]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2K1-1; Sequence=Displayed; Name=2; IsoId=Q9Y2K1-2; Sequence=VSP_040976; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21706167}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20797634}. Note=Localized in dot-like structures in the nucleus (PubMed:21706167). Colocalized with SMRT in nuclear bodies (PubMed:20797634). The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies(PubMed:20797634). {ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167}.


uniprotID: O95159
geneSymbol: ZFPL1
name: Zinc finger protein-like 1 (Zinc finger protein MCG4)
length: 310
go: ENSG00000162300;
snps: rs35251366
sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; nucleus [GO:0005634]; DNA binding [GO:0003677]; zinc ion binding [GO:0008270]; regulation of transcription, DNA-templated [GO:0006355]; vesicle-mediated transport [GO:0016192]

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:18323775}; Single-pass membrane protein {ECO:0000269|PubMed:18323775}.


uniprotID: Q8N8J6
geneSymbol: ZNF615
reactome: R-HSA-212436;
name: Zinc finger protein 615
length: 731
go: ENSG00000197619;
snps: rs10500311 rs1978717 rs16983353
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N8J6-1; Sequence=Displayed; Name=2; IsoId=Q8N8J6-2; Sequence=VSP_029582; Name=3; IsoId=Q8N8J6-3; Sequence=VSP_039717, VSP_029582; 


uniprotID: Q401N2
geneSymbol: ZACN
length: 412
go: ENSG00000186919;
snps: rs2257020
name:
Zinc-activated ligand-gated ion channel (Ligand-gated ion channel zinc-activated 1) (Ligand-gated ion-channel receptor L2)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; synapse [GO:0045202]; extracellular ligand-gated ion channel activity [GO:0005230]; ligand-gated ion channel activity [GO:0015276]; transmembrane signaling receptor activity [GO:0004888]; zinc ion binding [GO:0008270]; chemical synaptic transmission [GO:0007268]; ion transmembrane transport [GO:0034220]; nervous system process [GO:0050877]; regulation of membrane potential [GO:0042391]; response to zinc ion [GO:0010043]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q401N2-1; Sequence=Displayed; Name=2; IsoId=Q401N2-2; Sequence=VSP_030911, VSP_030912; Name=3; IsoId=Q401N2-3; Sequence=VSP_030909, VSP_030910; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16083862}; Multi-pass membrane protein {ECO:0000269|PubMed:16083862}.


uniprotID: O14771
geneSymbol: ZNF213
reactome: R-HSA-212436;
length: 459
go: ENSG00000085644;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
name:
Zinc finger protein 213 (Putative transcription factor CR53) (Zinc finger protein with KRAB and SCAN domains 21)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O14771-1; Sequence=Displayed; Name=2; IsoId=O14771-2; Sequence=VSP_055942, VSP_055943; Note=No experimental confirmation available.; 


uniprotID: Q6DD87
geneSymbol: ZNF787
name: Zinc finger protein 787 (TTF-I-interacting peptide 20)
length: 382
go: ENSG00000142409;
snps: rs4077285
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: P17028
geneSymbol: ZNF24
pdb: 1X6E;3LHR;
length: 368
go: ENSG00000172466;
snps: rs2032729 rs3568
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:24224020}.
name:
Zinc finger protein 24 (Retinoic acid suppression protein A) (RSG-A) (Zinc finger and SCAN domain-containing protein 3) (Zinc finger protein 191) (Zinc finger protein KOX17)

sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; zinc ion binding [GO:0008270]; myelination [GO:0042552]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P17028-1; Sequence=Displayed; Name=2; IsoId=P17028-2; Sequence=VSP_039219, VSP_039220; 


uniprotID: Q8N782
geneSymbol: ZNF525
name: Zinc finger protein 525
length: 197
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:
MSSLTYHHRLHTGEKPYKCEECDKAFRHNSALQRHRRIHTGEKPHKCNECGKTFSQKSYLACHRSIHTGKKPYECEECDKAFSFKSNLESHRITHTGEKPYKCNDCGKTFSHMSTLTCHRRLHTGEKPYKCEECDEAFRFKSSLERHRRIHNGEKLYKCNECGKTFSQELSLTCHCRLHSGEKPCKCGECDKAYSFK


uniprotID: Q8N1W2
geneSymbol: ZNF710
reactome: R-HSA-212436;
name: Zinc finger protein 710
length: 664
go: ENSG00000140548;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q3MIS6
geneSymbol: ZNF528
reactome: R-HSA-212436;
name: Zinc finger protein 528
length: 628
go: ENSG00000167555;
snps: rs324109
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q3MIS6-1; Sequence=Displayed; Name=2; IsoId=Q3MIS6-2; Sequence=VSP_023662; 


uniprotID: O43309
geneSymbol: ZSCAN12
length: 604
go: ENSG00000158691;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
name:
Zinc finger and SCAN domain-containing protein 12 (Zinc finger protein 305) (Zinc finger protein 96)

sequence:


uniprotID: Q14587
geneSymbol: ZNF268
reactome: R-HSA-212436;
name: Zinc finger protein 268 (Zinc finger protein HZF3)
length: 947
go: ENSG00000090612;
snps: rs7975069
pdb:
2EL4;2EL5;2EL6;2EM1;2EMV;2EMW;2EMX;2EMY;2EN0;2EN6;2EN7;2EOF;2EOG;2EOI;2EOJ;2EOK;2EOL;2EOP;2EPV;2EPW;2EPY;2YTF;2YTQ;

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; cell differentiation [GO:0030154]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of cell proliferation [GO:0008285]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of apoptotic process [GO:0043065]; positive regulation of cell differentiation [GO:0045597]; positive regulation of cell migration [GO:0030335]; positive regulation of cell proliferation [GO:0008284]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein homodimerization activity [GO:0090073]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of mitotic cell cycle [GO:0007346]; regulation of protein heterodimerization activity [GO:0043497]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1; Synonyms=ZNF268a, KW-4 variant-1; IsoId=Q14587-1; Sequence=Displayed; Name=2; Synonyms=ZNF268s, KW-4 variant-2; IsoId=Q14587-2; Sequence=VSP_006909; Name=3; Synonyms=ZNF268c; IsoId=Q14587-3; Sequence=VSP_053461, VSP_053471; Name=4; Synonyms=ZNF268d; IsoId=Q14587-4; Sequence=VSP_053462, VSP_053467; Name=5; Synonyms=ZNF268e; IsoId=Q14587-6; Sequence=VSP_053466, VSP_053468; Name=6; Synonyms=ZNF268f; IsoId=Q14587-7; Sequence=VSP_053464, VSP_053465; Name=7; Synonyms=ZNF268g; IsoId=Q14587-8; Sequence=VSP_053463, VSP_053469, VSP_053470; 

location:
SUBCELLULAR LOCATION: Isoform 1: Nucleus {ECO:0000269|PubMed:23665872}.; SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:23665872}. Cytoplasm {ECO:0000269|PubMed:23665872}.


uniprotID: Q8TB69
geneSymbol: ZNF519
reactome: R-HSA-212436;
name: Zinc finger protein 519
length: 540
go: ENSG00000175322;
snps: rs16941623 rs10221432 rs2159940 rs8094412
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8N3Z6
geneSymbol: ZCCHC7
name: Zinc finger CCHC domain-containing protein 7 (TRAMP-like complex RNA-binding factor ZCCHC7)
length: 543
go: ENSG00000147905;
snps: rs35119826 rs1051465
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21855801}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N3Z6-1; Sequence=Displayed; Name=2; IsoId=Q8N3Z6-2; Sequence=VSP_013841, VSP_013842; 


uniprotID: Q96LW1
geneSymbol: ZNF354B
reactome: R-HSA-212436;
name: Zinc finger protein 354B
length: 612
go: ENSG00000178338;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; negative regulation of transcription by RNA polymerase II [GO:0000122]


uniprotID: O96006
geneSymbol: ZBED1
reactome: R-HSA-4551638;
pdb: 2CT5;
name: Zinc finger BED domain-containing protein 1 (Putative Ac-like transposable element) (dREF homolog)
length: 694
go: ENSG00000214717;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12663651}. Note=In granular structures.
sequence:

opentargets:
nuclear chromosome [GO:0000228]; nucleoplasm [GO:0005654]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; SUMO transferase activity [GO:0019789]; transposase activity [GO:0004803]; positive regulation of transcription by RNA polymerase II [GO:0045944]


uniprotID: P58317
geneSymbol: ZNF121
name: Zinc finger protein 121 (Zinc finger protein 20)
length: 390
go: ENSG00000197961;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: A6NK75
geneSymbol: ZNF98
name: Zinc finger protein 98 (Zinc finger protein 739) (Zinc finger protein F7175)
length: 572
go: ENSG00000197360;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: A8MQ14
geneSymbol: ZNF850
name: Zinc finger protein 850
length: 1090
go: ENSG00000267041;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: P52737
geneSymbol: ZNF136
reactome: R-HSA-212436;
name: Zinc finger protein 136
length: 540
go: ENSG00000196646;
snps: rs10425995
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription corepressor activity [GO:0003714]; negative regulation of transcription by RNA polymerase II [GO:0000122]; transcription by RNA polymerase II [GO:0006366]


uniprotID: Q96M85
name: Putative uncharacterized protein FLJ32756
length: 177
sequence:
MSHSRRAAPTQDQCHTPGFPTSRETSGSIWQARICGSLQALDTWRTHIPRKSPAPTQASQICLLLPESPWRNPTPRGFLKPLINWDAILYFKEKRNIQVTTQAHPQNQASCSSQEVATPGLVPQAAAPKVYERSHDNLNAEAQGLAGAQVSKPQNPITRLCSLKEQSILKIFTKQSI


uniprotID: Q6ZMY9
geneSymbol: ZNF517
reactome: R-HSA-212436;
name: Zinc finger protein 517
length: 492
go: ENSG00000197363;
snps: rs2976649
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9Y6R6
geneSymbol: ZNF780B
name: Zinc finger protein 780B (Zinc finger protein 779)
length: 833
go: ENSG00000128000;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O15014
geneSymbol: ZNF609
name: Zinc finger protein 609
length: 1411
go: ENSG00000180357;
location: SUBCELLULAR LOCATION: Isoform 2: Nucleus {ECO:0000269|PubMed:28344082}.
sequence:

opentargets:
integrator complex [GO:0032039]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; muscle organ development [GO:0007517]; positive regulation of neuron migration [GO:2001224]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myoblast proliferation [GO:2000291]; regulation of transcription by RNA polymerase II [GO:0006357]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15014-1; Sequence=Displayed; Name=2; IsoId=O15014-2; Sequence=VSP_059082, VSP_059083; Note=Produced by a back-splicing reaction which joins the 5'-splice site of the first coding exon with the 3'-splice site of the upstream intron resulting in a circular RNA, called circ-ZNF609. The translation starts with the same initiator methionine as that of the linear transcript encoding isoform 1. The stop codon is created upon circularization. {ECO:0000269|PubMed:28344082}; 


uniprotID: Q9Y462
geneSymbol: ZNF711
reactome: R-HSA-212436;
name: Zinc finger protein 711 (Zinc finger protein 6)
length: 761
go: ENSG00000147180;
snps: rs367654949 rs148609081 rs1060505033 rs777239465 rs368788919 rs760346140
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:20346720}.
sequence:

opentargets:
nucleus [GO:0005634]; chromatin DNA binding [GO:0031490]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y462-1; Sequence=Displayed; Name=2; IsoId=Q9Y462-2; Sequence=VSP_016912; Name=3; IsoId=Q9Y462-3; Sequence=VSP_039887; Note=No experimental confirmation available.; 


uniprotID: Q9H8V8
name: Putative uncharacterized protein FLJ13197
length: 135
sequence:
MKPDWPRRGAAGTRVRSRGEGDGTYFARRGAGRRRREIKAPIRAAWSPPSAAMSGLQSGRRWRPQGTGTGARAAGALAALRLGPRLRAAPLLAPLWLLAPTPDSHMTPAPLALRASRGWRENNLSDYQYSWMQKC


uniprotID: Q9HAA7
name: Putative uncharacterized protein FLJ11871
length: 133
sequence:
MLFGIRILVNTPSPLVTGLHHYNPSIHRDQGECANQWRKGPGSAHLAGLAGRCSLINTPSPLVTGLQRYNPSMDRAQGMCASLEEEAGLCKPLWAWWELQSHKHSQTSHHRAAGLQSQHAPGSGRVRITGGKV


uniprotID: Q5PR19
name: Putative UPF0607 protein LOC392364
length: 223
sequence:


uniprotID: Q5BJH7
geneSymbol: YIF1B
name: Protein YIF1B (YIP1-interacting factor homolog B)
length: 314
go: ENSG00000167645;
snps: rs11556992
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum-Golgi intermediate compartment [GO:0005793]; integral component of Golgi membrane [GO:0030173]; ER to Golgi vesicle-mediated transport [GO:0006888]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q5BJH7-1; Sequence=Displayed; Name=2; IsoId=Q5BJH7-2; Sequence=VSP_028650; Name=3; IsoId=Q5BJH7-3; Sequence=VSP_028651; Name=4; IsoId=Q5BJH7-4; Sequence=VSP_028651, VSP_028653, VSP_028654; Name=5; IsoId=Q5BJH7-5; Sequence=VSP_028651, VSP_028652, VSP_028655; Note=No experimental confirmation available.; Name=6; IsoId=Q5BJH7-6; Sequence=VSP_046823; Note=Gene prediction based on EST data.; 


uniprotID: Q08ER8
geneSymbol: ZNF543
reactome: R-HSA-212436;
name: Zinc finger protein 543
length: 600
snps: rs6510057 rs8100491 rs1968090 rs35238720 rs10411486 rs10410649
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8IYX0
geneSymbol: ZNF679
reactome: R-HSA-212436;
name: Zinc finger protein 679
length: 411
go: ENSG00000197123;
snps: rs12154540 rs17139320 rs1830035 rs1830036
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q13106
geneSymbol: ZNF154
reactome: R-HSA-212436;
name: Zinc finger protein 154
length: 437
go: ENSG00000179909;
snps: rs34282745 rs2074078 rs2188736 rs34746514
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: Q7Z398
geneSymbol: ZNF550
reactome: R-HSA-212436;
name: Zinc finger protein 550
length: 422
go: ENSG00000251369;
snps: rs1548476
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z398-1; Sequence=Displayed; Name=2; IsoId=Q7Z398-2; Sequence=VSP_018380; Note=No experimental confirmation available.; 


uniprotID: Q9C0A1
geneSymbol: ZFHX2
name: Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 2) (ZFH-2)
length: 2572
go: ENSG00000136367;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription regulatory region DNA binding [GO:0044212]; zinc ion binding [GO:0008270]; adult behavior [GO:0030534]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9C0A1-1; Sequence=Displayed; Name=2; IsoId=Q9C0A1-2; Sequence=VSP_039496, VSP_039497; 


uniprotID: Q9UK10
geneSymbol: ZNF225
reactome: R-HSA-212436;
name: Zinc finger protein 225
length: 706
go: ENSG00000256294;
snps: rs34863330 rs16978738
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O43830
geneSymbol: ZNF73
name: Zinc finger protein 73 (Zinc finger protein 186) (hZNF2)
length: 326
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q5SVQ8
geneSymbol: ZBTB41
name: Zinc finger and BTB domain-containing protein 41
length: 909
go: ENSG00000177888;
snps: rs10494751
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5SVQ8-1; Sequence=Displayed; Name=2; IsoId=Q5SVQ8-2; Sequence=VSP_023092, VSP_023093; Note=No experimental confirmation available.; 


uniprotID: P17097
geneSymbol: ZNF7
name: Zinc finger protein 7 (Zinc finger protein HF.16) (Zinc finger protein KOX4)
length: 686
go: ENSG00000147789;
snps: rs1735169 rs2228180 rs1735170
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; multicellular organism development [GO:0007275]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P17097-1; Sequence=Displayed; Name=2; IsoId=P17097-2; Sequence=VSP_054822; Name=3; IsoId=P17097-3; Sequence=VSP_054823, VSP_054824; 


uniprotID: P16415
geneSymbol: ZNF823
name: Zinc finger protein 823 (Zinc finger protein ZFP-36)
length: 610
go: ENSG00000197933;
snps: rs3745663
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P16415-1; Sequence=Displayed; Name=2; IsoId=P16415-2; Sequence=VSP_055972; Note=No experimental confirmation available.; 


uniprotID: Q86VM9
geneSymbol: ZC3H18
name: Zinc finger CCCH domain-containing protein 18 (Nuclear protein NHN1)
length: 953
go: ENSG00000158545;
snps: rs34808360 rs17855686
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nuclear speck [GO:0016607]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86VM9-1; Sequence=Displayed; Name=2; IsoId=Q86VM9-2; Sequence=VSP_029453, VSP_029454, VSP_029455; 


uniprotID: Q9H7X3
geneSymbol: ZNF696
reactome: R-HSA-212436;
name: Zinc finger protein 696
length: 374
go: ENSG00000185730;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O15015
geneSymbol: ZNF646
name: Zinc finger protein 646
length: 1829
go: ENSG00000167395;
snps: rs28407985 rs749670 rs17641067 rs35713203 rs35376811 rs3751856 rs7196726 rs34259949
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15015-1; Sequence=Displayed; Name=2; IsoId=O15015-2; Sequence=VSP_039873; 


uniprotID: Q6P9G9
geneSymbol: ZNF449
name: Zinc finger protein 449 (Zinc finger and SCAN domain-containing protein 19)
length: 518
go: ENSG00000173275;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; spermatogonial cell division [GO:0007284]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6P9G9-1; Sequence=Displayed; Name=2; IsoId=Q6P9G9-2; Sequence=VSP_011949, VSP_011950; Note=No experimental confirmation available.; Name=3; IsoId=Q6P9G9-3; Sequence=VSP_011951, VSP_011952; Note=No experimental confirmation available.; 


uniprotID: O15156
geneSymbol: ZBTB7B
length: 539
go: ENSG00000160685;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q64321}.
name:
Zinc finger and BTB domain-containing protein 7B (Krueppel-related zinc finger protein cKrox) (hcKrox) (T-helper-inducing POZ/Krueppel-like factor) (Zinc finger and BTB domain-containing protein 15) (Zinc finger protein 67 homolog) (Zfp-67) (Zinc finger protein 857B) (Zinc finger protein Th-POK)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; enhancer sequence-specific DNA binding [GO:0001158]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; adaptive thermogenesis [GO:1990845]; ectoderm development [GO:0007398]; interleukin-17 secretion [GO:0072615]; lactation [GO:0007595]; negative regulation of CD8-positive, alpha-beta T cell differentiation [GO:0043377]; negative regulation of gene expression [GO:0010629]; negative regulation of NK T cell proliferation [GO:0051141]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of transcription by RNA polymerase II [GO:0000122]; NK T cell differentiation [GO:0001865]; positive regulation of brown fat cell differentiation [GO:0090336]; positive regulation of CD4-positive, alpha-beta T cell differentiation [GO:0043372]; positive regulation of cold-induced thermogenesis [GO:0120162]; positive regulation of gene expression [GO:0010628]; positive regulation of histone deacetylation [GO:0031065]; positive regulation of insulin receptor signaling pathway [GO:0046628]; positive regulation of SREBP signaling pathway [GO:2000640]; regulation of transcription involved in cell fate commitment [GO:0060850]; response to insulin [GO:0032868]; transcription by RNA polymerase II [GO:0006366]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15156-1; Sequence=Displayed; Name=2; IsoId=O15156-2; Sequence=VSP_044721; Note=No experimental confirmation available.; 


uniprotID: Q49AG3
geneSymbol: ZBED5
name: Zinc finger BED domain-containing protein 5 (Transposon-derived Buster1 transposase-like protein)
length: 693
go: ENSG00000236287;
snps: rs2232918 rs2232919 rs2232920 rs1046297
sequence:


uniprotID: P86452
geneSymbol: ZBED6
name: Zinc finger BED domain-containing protein 6
length: 979
go: ENSG00000257315;
sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; protein dimerization activity [GO:0046983]; negative regulation of transcription, DNA-templated [GO:0045892]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:D2EAC2}. Nucleus, nucleolus {ECO:0000250|UniProtKB:D2EAC2}. Note=Located predominantly in the nucleolus but is also dispersed throughout the nucleus. {ECO:0000250|UniProtKB:D2EAC2}.


uniprotID: Q66K41
geneSymbol: ZNF385C
name: Zinc finger protein 385C
length: 424
go: ENSG00000187595;
opentargets: nucleus [GO:0005634]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q66K41-1; Sequence=Displayed; Name=2; IsoId=Q66K41-2; Sequence=VSP_031546; Note=No experimental confirmation available.; 


uniprotID: Q5W0Z9
geneSymbol: ZDHHC20
pdb: 6BML;6BMM;6BMN;
length: 365
go: ENSG00000180776;
name:
Palmitoyltransferase ZDHHC20 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 20) (DHHC-20)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of Golgi membrane [GO:0030173]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; zinc ion binding [GO:0008270]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q5W0Z9-1; Sequence=Displayed; Name=2; IsoId=Q5W0Z9-2; Sequence=VSP_016276, VSP_016277; Note=No experimental confirmation available.; Name=3; IsoId=Q5W0Z9-3; Sequence=VSP_040481, VSP_040482; Name=4; IsoId=Q5W0Z9-4; Sequence=VSP_056002; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:29326245}; Multi-pass membrane protein {ECO:0000269|PubMed:29326245}. Cell membrane {ECO:0000269|PubMed:27153536}; Multi-pass membrane protein {ECO:0000269|PubMed:29326245}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:27153536}.


uniprotID: P0CG32
geneSymbol: ZCCHC18
name: Zinc finger CCHC domain-containing protein 18
length: 403
go: ENSG00000166707;
opentargets: metal ion binding [GO:0046872]
sequence:


uniprotID: Q9NQZ8
geneSymbol: ZNF71
reactome: R-HSA-212436;
name: Endothelial zinc finger protein induced by tumor necrosis factor alpha (Zinc finger protein 71)
length: 489
go: ENSG00000197951;
snps: rs10405299 rs2072501 rs35392779
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]


uniprotID: Q9NYT6
geneSymbol: ZNF226
reactome: R-HSA-212436;
name: Zinc finger protein 226
length: 803
go: ENSG00000167380;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NYT6-1; Sequence=Displayed; Name=2; IsoId=Q9NYT6-2; Sequence=VSP_046853, VSP_046854; Note=No experimental confirmation available.; 


uniprotID: A8K554
geneSymbol: ZNF815P
name: Putative protein ZNF815
length: 130
sequence:
MEEEEIRTWSFPEEVWQVATQPDSQQQHEDQHLSHTFLDKKDWTGNELHECNELGKKLHQNPNLLPSKQQVRTRDLCRKSLMCNLDFTPNAYLARRRFQCDGHGNFFSVRNLKLHLQERIHAEVTSVEVL


uniprotID: Q7Z4V0
geneSymbol: ZNF438
name: Zinc finger protein 438
length: 828
go: ENSG00000183621;
snps: rs10160116 rs35346752
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17669267}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q7Z4V0-1; Sequence=Displayed; Name=2; IsoId=Q7Z4V0-2; Sequence=VSP_019800; Name=3; IsoId=Q7Z4V0-3; Sequence=VSP_019799; Note=No experimental confirmation available.; 


uniprotID: P51522
geneSymbol: ZNF83
name: Zinc finger protein 83 (Zinc finger protein 816B) (Zinc finger protein HPF1)
length: 516
go: ENSG00000167766;
snps: rs3786490 rs1056185 rs329940 rs11545619
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P51522-1; Sequence=Displayed; Name=2; IsoId=P51522-2; Sequence=VSP_037663; 


uniprotID: Q8WYQ9
geneSymbol: ZCCHC14
name: Zinc finger CCHC domain-containing protein 14 (BDG-29)
length: 949
go: ENSG00000140948;
snps: rs11648852 rs13338940 rs3748400
sequence:

opentargets:
nucleic acid binding [GO:0003676]; phosphatidylinositol binding [GO:0035091]; zinc ion binding [GO:0008270]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WYQ9-1; Sequence=Displayed; Name=2; IsoId=Q8WYQ9-2; Sequence=VSP_013843; Note=No experimental confirmation available.; 


uniprotID: Q96NL3
geneSymbol: ZNF599
reactome: R-HSA-212436;
name: Zinc finger protein 599
length: 588
go: ENSG00000153896;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96NL3-1; Sequence=Displayed; Name=2; IsoId=Q96NL3-2; Sequence=VSP_018385, VSP_018386; Note=No experimental confirmation available.; 


uniprotID: Q8N9L1
geneSymbol: ZIC4
name: Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4)
length: 334
go: ENSG00000174963;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8N9L1-1; Sequence=Displayed; Name=2; IsoId=Q8N9L1-2; Sequence=VSP_017066, VSP_017067; Note=May be due to an intron retention. No experimental confirmation available.; Name=3; IsoId=Q8N9L1-3; Sequence=VSP_044484; Note=No experimental confirmation available.; Name=4; IsoId=Q8N9L1-4; Sequence=VSP_045529; Note=No experimental confirmation available.; Name=5; IsoId=Q8N9L1-5; Sequence=VSP_046072; Note=No experimental confirmation available.; 


uniprotID: Q8IZ26
geneSymbol: ZNF34
reactome: R-HSA-212436;
name: Zinc finger protein 34 (Zinc finger protein KOX32)
length: 560
go: ENSG00000196378;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]


uniprotID: P24278
geneSymbol: ZBTB25
name: Zinc finger and BTB domain-containing protein 25 (Zinc finger protein 46) (Zinc finger protein KUP)
length: 435
go: ENSG00000089775;
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; gene expression [GO:0010467]


uniprotID: Q5EBM4
geneSymbol: ZNF542P
name: Putative zinc finger protein 542 (Zinc finger protein 542 pseudogene)
length: 170
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:
MLENYQNLVWLGLSISKSVISLLEKRKLPWIMAKEEIRGPLPGYFKVSEMTISQEPKAKTRTLFGKDVPGAEIKELSAKRAINEVLSQFDTVIKCTRNVCKECGNLYCHNMQLTLHKRNHTQKKCNQCLDCGKYFTRQSTLIQHQRIHTGERPYKCNECIKTFNQRAHLT

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5EBM4-1; Sequence=Displayed; Name=2; IsoId=Q5EBM4-2; Sequence=VSP_055414; 


uniprotID: Q86XI8
geneSymbol: ZSWIM9
name: Uncharacterized protein ZSWIM9
length: 627
go: ENSG00000185453;
sequence:

opentargets:
nucleus [GO:0005634]; multicellular organism development [GO:0007275]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86XI8-1; Sequence=Displayed; Name=2; IsoId=Q86XI8-2; Sequence=VSP_059340; 


uniprotID: O75541
geneSymbol: ZNF821
name: Zinc finger protein 821
length: 412
go: ENSG00000102984;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity [GO:0003700]; metal ion binding [GO:0046872]; transcription regulatory region DNA binding [GO:0044212]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75541-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=O75541-2; Sequence=VSP_030933; 


uniprotID: A2A288
geneSymbol: ZC3H12D
length: 527
go: ENSG00000178199;
snps: rs7747948 rs61997220
name:
Probable ribonuclease ZC3H12D (EC 3.1.-.-) (MCP-induced protein 4) (Transformed follicular lymphoma) (Zinc finger CCCH domain-containing protein 12D) (p34)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; negative regulation of cell growth [GO:0030308]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1 {ECO:0000269|PubMed:14574404}; Synonyms=P58TFL, TFL1; IsoId=A2A288-1; Sequence=Displayed; Name=2; IsoId=A2A288-3; Sequence=VSP_052853; Note=No experimental confirmation available. {ECO:0000305}; Name=3; Synonyms=P36TFL, TFL2; IsoId=A2A288-4; Sequence=VSP_040794, VSP_040795; 

location:
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:26134560}. Note=Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560). {ECO:0000269|PubMed:26134560}.; SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Note=Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Nucleus.


uniprotID: Q86UK7
geneSymbol: ZNF598
name: E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598)
length: 904
snps: rs11556528 rs11248905 rs2286469 rs2286468
sequence:

opentargets:
metal ion binding [GO:0046872]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; ubiquitin protein ligase activity [GO:0061630]; protein monoubiquitination [GO:0006513]; protein ubiquitination [GO:0016567]; rescue of stalled ribosome [GO:0072344]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86UK7-1; Sequence=Displayed; Name=2; IsoId=Q86UK7-2; Sequence=VSP_020661, VSP_020663, VSP_020664; Note=No experimental confirmation available. {ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:24275569}; Name=3; IsoId=Q86UK7-3; Sequence=VSP_020663; Note=No experimental confirmation available. {ECO:0000244|PubMed:19690332, ECO:0000244|PubMed:24275569}; Name=4; IsoId=Q86UK7-4; Sequence=VSP_020660, VSP_020662, VSP_020664, VSP_020665; Note=No experimental confirmation available.; 


uniprotID: Q96NJ3
geneSymbol: ZNF285
reactome: R-HSA-212436;
name: Zinc finger protein 285 (Zinc finger protein 285A)
length: 590
snps: rs2571089 rs12610859
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96NJ3-1; Sequence=Displayed; Name=2; IsoId=Q96NJ3-2; Sequence=VSP_037502; 


uniprotID: Q6PG37
geneSymbol: ZNF790
reactome: R-HSA-212436;
name: Zinc finger protein 790
length: 636
go: ENSG00000197863;
snps: rs3745775 rs4369791
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8IVQ6
geneSymbol: ZDHHC21
reactome: R-HSA-203615;
length: 265
go: ENSG00000175893;
name:
Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 21) (DHHC-21)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; palmitoyltransferase activity [GO:0016409]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; hair follicle development [GO:0001942]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]; regulation of nitric-oxide synthase activity [GO:0050999]; sebaceous gland development [GO:0048733]

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus {ECO:0000250}.


uniprotID: Q5T5D7
geneSymbol: ZNF684
reactome: R-HSA-212436;
name: Zinc finger protein 684
length: 378
go: ENSG00000117010;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q15935
geneSymbol: ZNF77
reactome: R-HSA-212436;
name: Zinc finger protein 77 (ZNFpT1)
length: 545
go: ENSG00000175691;
snps: rs12610412 rs12609268 rs34603238 rs34705382 rs35411355
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: A2RRD8
geneSymbol: ZNF320
reactome: R-HSA-212436;
name: Zinc finger protein 320
length: 509
go: ENSG00000182986;ENSG00000204604;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q96H86
geneSymbol: ZNF764
reactome: R-HSA-212436;
name: Zinc finger protein 764
length: 408
go: ENSG00000169951;
snps: rs17850402
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96H86-1; Sequence=Displayed; Name=2; IsoId=Q96H86-2; Sequence=VSP_045352; Note=No experimental confirmation available.; 


uniprotID: A6NC05
geneSymbol: C5orf63
name: Glutaredoxin-like protein C5orf63
length: 138
go: ENSG00000164241;
opentargets: oxidation-reduction process [GO:0055114]
sequence:
MLWFQGNSMQLARSSFGLFLRNCSASKTTLPVLTLFTKDPCPLCDEAKEVLKPYENRQPYKDQKLPGTRRRRSPSSPSHPHMASQSGKRYNLTLNQVLSFDYDMGLDAPKTISSDCGAFYCLRMFKSPDMTCCFYPKQ

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=A6NC05-1; Sequence=Displayed; Name=2; IsoId=A6NC05-2; Sequence=VSP_044904; Note=No experimental confirmation available.; 


uniprotID: O15498
geneSymbol: YKT6
reactome: R-HSA-204005;R-HSA-6807878;R-HSA-6811438;
name: Synaptobrevin homolog YKT6 (EC 2.3.1.-)
length: 198
go: ENSG00000106636;
sequence:
MKLYSLSVLYKGEAKVVLLKAAYDVSSFSFFQRSSVQEFMTFTSQLIVERSSKGTRASVKEQDYLCHVYVRNDSLAGVVIADNEYPSRVAFTLLEKVLDEFSKQVDRIDWPVGSPATIHYPALDGHLSRYQNPREADPMTKVQAELDETKIILHNTMESLLERGEKLDDLVSKSEVLGTQSKAFYKTARKQNSCCAIM

opentargets:
apical dendrite [GO:0097440]; basal dendrite [GO:0097441]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of plasma membrane [GO:0005887]; mitochondrion [GO:0005739]; neuronal cell body [GO:0043025]; SNARE complex [GO:0031201]; transport vesicle [GO:0030133]; cadherin binding [GO:0045296]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; SNAP receptor activity [GO:0005484]; ER to Golgi vesicle-mediated transport [GO:0006888]; protein transport [GO:0015031]; retrograde transport, endosome to Golgi [GO:0042147]; vesicle docking involved in exocytosis [GO:0006904]; vesicle targeting [GO:0006903]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15498-1; Sequence=Displayed; Name=2; IsoId=O15498-2; Sequence=VSP_056071; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Probably cycles through vesicles between Golgi and endosomes.


uniprotID: P18887
geneSymbol: XRCC1
reactome: R-HSA-110381;R-HSA-5649702;R-HSA-5685939;R-HSA-5696397;R-HSA-6782210;
pdb: 1CDZ;1XNA;1XNT;2D8M;2W3O;3K75;3K77;3LQC;5E6Q;5W7X;5W7Y;
name: DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
length: 633
sequence:

opentargets:
ERCC4-ERCC1 complex [GO:0070522]; nuclear chromatin [GO:0000790]; nuclear chromosome, telomeric region [GO:0000784]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; 3' overhang single-stranded DNA endodeoxyribonuclease activity [GO:1990599]; DNA ligase activity [GO:0003909]; enzyme binding [GO:0019899]; oxidized DNA binding [GO:0032356]; base-excision repair [GO:0006284]; base-excision repair, DNA ligation [GO:0006288]; cerebellum morphogenesis [GO:0021587]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; hippocampus development [GO:0021766]; negative regulation of protection from non-homologous end joining at telomere [GO:1905765]; negative regulation of protein ADP-ribosylation [GO:0010836]; nucleotide-excision repair, DNA gap filling [GO:0006297]; positive regulation of DNA ligase activity [GO:1904877]; positive regulation of single strand break repair [GO:1903518]; replication-born double-strand break repair via sister chromatid exchange [GO:1990414]; response to drug [GO:0042493]; response to hydroperoxide [GO:0033194]; response to hypoxia [GO:0001666]; response to organic substance [GO:0010033]; single strand break repair [GO:0000012]; telomeric DNA-containing double minutes formation [GO:0061819]; transcription-coupled nucleotide-excision repair [GO:0006283]; voluntary musculoskeletal movement [GO:0050882]

snps:
rs2307186 rs2307171 rs25496 rs2228487 rs2307180 rs2307191 rs1799782 rs25489 rs2307188 rs25490 rs25491 rs25487 rs761564262 rs2307184 rs25474 rs2307167 rs2307166 rs2307177 rs2682557 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:28002403}. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage. {ECO:0000269|PubMed:28002403}.


uniprotID: O43543
geneSymbol: XRCC2
reactome: R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693616;
name: DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)
length: 280
go: ENSG00000196584;
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; Rad51B-Rad51C-Rad51D-XRCC2 complex [GO:0033063]; replication fork [GO:0005657]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; DNA-dependent ATPase activity [GO:0008094]; centrosome cycle [GO:0007098]; DNA repair [GO:0006281]; double-strand break repair via homologous recombination [GO:0000724]; in utero embryonic development [GO:0001701]; meiotic cell cycle [GO:0051321]; mitotic cell cycle [GO:0000278]; multicellular organism growth [GO:0035264]; negative regulation of neuron apoptotic process [GO:0043524]; positive regulation of neurogenesis [GO:0050769]; regulation of fibroblast apoptotic process [GO:2000269]; response to gamma radiation [GO:0010332]; response to X-ray [GO:0010165]; somitogenesis [GO:0001756]; strand invasion [GO:0042148]

snps:
rs4987090 rs587780126 rs569810249 rs730882043 rs140214637 rs185815454 rs765276614 rs778143946 rs139219364 rs3218536 rs775565256 rs61762969 rs765021741 rs3218537 rs534746330 rs190900560 rs759300252 rs145085742 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21276791}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21276791}.


uniprotID: Q8NFD4
name: Uncharacterized protein FLJ76381
length: 153
sequence:
MGGFGSRFWQEGVWDRDLEKSTRLEEDAMESEPLAGTKTRGRGRRRWEARHGWTLPAHASQPSPRTVVATATGAEVSACAGRSAGTRVARPESQLSHLYGWDKYSNPRPSRRARAVARVHALEQAPILCRALRWGLTQFLRGTSPVTQSVPFS


uniprotID: Q6ZSN1
name: Putative uncharacterized protein FLJ45355
length: 163
sequence:
MGVPRAREGRGAGSQSPPRGRCLHPFRWGSQDRGRGEGLALSPLLPGVPPPPAMGVPRDRGGRGAGSQSTPRGGCLLPPRLGSQQPAGEEGLVLSPRLAGDASPCCDGSPKSQGVKRGWLSVPTSRGVPPPPAIGVLIARGGRGAGSQSLPRGWSFTPLRWGS


uniprotID: Q9Y3C0
geneSymbol: WASHC3
name: WASH complex subunit 3 (Coiled-coil domain-containing protein 53)
length: 194
go: ENSG00000120860;
location: SUBCELLULAR LOCATION: Early endosome {ECO:0000305}.
sequence:
MDEDGLPLMGSGIDLTKVPAIQQKRTVAFLNQFVVHTVQFLNRFSTVCEEKLADLSLRIQQIETTLNILDAKLSSIPGLDDVTVEVSPLNVTSVTNGAHPEATSEQPQQNSTQDSGLQESEVSAENILTVAKDPRYARYLKMVQVGVPVMAIRNKMISEGLDPDLLERPDAPVPDGESEKTVEESSDSESSFSD

opentargets:
early endosome [GO:0005769]; WASH complex [GO:0071203]; actin filament polymerization [GO:0030041]; exocytosis [GO:0006887]; protein transport [GO:0015031]


uniprotID: Q8N2E2
geneSymbol: VWDE
name: von Willebrand factor D and EGF domain-containing protein
length: 1590
go: ENSG00000146530;
snps: rs963323 rs6460939 rs2053380 rs6967385 rs2192828
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
cell surface [GO:0009986]; extracellular region [GO:0005576]; signaling receptor binding [GO:0005102]; anatomical structure development [GO:0048856]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N2E2-1; Sequence=Displayed; Name=2; IsoId=Q8N2E2-3; Sequence=VSP_055465; Note=No experimental confirmation available.; 


uniprotID: A8MVM7
name: Putative uncharacterized protein ENSP00000382790
length: 634
sequence:


uniprotID: P07947
geneSymbol: YES1
pdb: 2HDA;
name: Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes)
length: 543
go: ENSG00000176105;
drug: DB01254;
snps: rs34580680 rs35126906
reactome:
R-HSA-1227986;R-HSA-1433557;R-HSA-1433559;R-HSA-2029481;R-HSA-210990;R-HSA-2682334;R-HSA-389356;R-HSA-389513;R-HSA-3928662;R-HSA-3928663;R-HSA-3928665;R-HSA-8940973;R-HSA-912631;

sequence:

opentargets:
actin filament [GO:0005884]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extrinsic component of cytoplasmic side of plasma membrane [GO:0031234]; focal adhesion [GO:0005925]; glutamatergic synapse [GO:0098978]; Golgi apparatus [GO:0005794]; microtubule organizing center [GO:0005815]; plasma membrane [GO:0005886]; postsynaptic specialization, intracellular component [GO:0099091]; ATP binding [GO:0005524]; enzyme binding [GO:0019899]; epidermal growth factor receptor binding [GO:0005154]; ion channel binding [GO:0044325]; non-membrane spanning protein tyrosine kinase activity [GO:0004715]; phosphotyrosine residue binding [GO:0001784]; protein tyrosine kinase activity [GO:0004713]; signaling receptor binding [GO:0005102]; cell differentiation [GO:0030154]; cellular protein modification process [GO:0006464]; cellular response to platelet-derived growth factor stimulus [GO:0036120]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; ephrin receptor signaling pathway [GO:0048013]; Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]; leukocyte migration [GO:0050900]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of peptidyl-tyrosine phosphorylation [GO:0050731]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of glucose transmembrane transport [GO:0010827]; regulation of vascular permeability [GO:0043114]; T cell costimulation [GO:0031295]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

location:
SUBCELLULAR LOCATION: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway.


uniprotID: Q96EC8
geneSymbol: YIPF6
reactome: R-HSA-432722;
name: Protein YIPF6 (YIP1 family member 6)
length: 236
go: ENSG00000181704;
snps: rs17850921
sequence:

opentargets:
cis-Golgi network [GO:0005801]; COPII-coated ER to Golgi transport vesicle [GO:0030134]; endoplasmic reticulum [GO:0005783]; Golgi medial cisterna [GO:0005797]; Golgi membrane [GO:0000139]; Golgi trans cisterna [GO:0000138]; integral component of membrane [GO:0016021]; trans-Golgi network [GO:0005802]; identical protein binding [GO:0042802]; intestinal epithelial cell development [GO:0060576]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96EC8-1; Sequence=Displayed; Name=2; IsoId=Q96EC8-2; Sequence=VSP_047121; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Note=Evenly distributed between cis- and trans-Golgi apparatus (PubMed:27999994). Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi (PubMed:28286305). {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.


uniprotID: Q9Y548
geneSymbol: YIPF1
name: Protein YIPF1 (YIP1 family member 1)
length: 306
go: ENSG00000058799;
sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi medial cisterna [GO:0005797]; Golgi trans cisterna [GO:0000138]; integral component of membrane [GO:0016021]; late endosome membrane [GO:0031902]; trans-Golgi network [GO:0005802]; transport vesicle [GO:0030133]; Rab GTPase binding [GO:0017137]; vesicle-mediated transport [GO:0016192]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y548-1; Sequence=Displayed; Name=2; IsoId=Q9Y548-2; Sequence=VSP_019437; 

location:
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}. Late endosome membrane {ECO:0000269|PubMed:27999994}. Note=Mainly localizes within medial-/trans-Golgi and trans-Golgi network (TGN), while less so within cis-Golgi. {ECO:0000269|PubMed:27999994, ECO:0000269|PubMed:28286305}.


uniprotID: Q6ZVU0
name: Putative uncharacterized protein FLJ42102
length: 165
sequence:
MVTKWWGQDPPVQLRSQLMLWIMELILWKFQSSVVGSSVVTWKISDVAGPHGDHSCSLQHLEQIIGSVSNYPRYTGSRSCDRGENPVSLSKRIKCTWMLGASGFPPRCPSGRDHSRDHPGKSQVPALELANQLAAWGLWSSVVKSWGFRAGETEAPISALSSAHA


uniprotID: Q6AWC8
name: Putative uncharacterized protein LOC100129027
length: 147
sequence:
MYWQNWTHNGRLWGAGVHLYLSRKQCALKNTSLSKFQTSHICKGSALQPQQASPGASSFLTCPELGVMYLKLVLGQMVQAVRRDSGLQPFGSLFLLITQKRAVLTPFLTKTWHSLRALVYRVWSLEESRYLQREKGLVDSFGVLWEE


uniprotID: Q6ZTI0
name: Putative uncharacterized protein FLJ44636
length: 123
sequence:
MPLPGTPGPVTTSPQTPTPRPLTTDWRILSGKGSGGSARAVSKLRSSSSGNSLLRIRDLGVRKSQEEAAPPSPRPQSRAHAQTTNPYWADTNTRPGAHPPEHGGVAALPAQVVGQCHQEATED


uniprotID: Q0VFX4
name: Putative uncharacterized protein LOC100128554
length: 171
sequence:
MLKKPSSLEQWEILGTSSGEFRCISRDCPGAGNNNREPSISTRGRTSSSKMVLPHPKVAEEAVGGPQSCKWLSCGLQGTGGGHLEGHPPRVSQESAPAGHTGISPSSSGVHLIQAKTAGWPQRVSSAEQCLLPIQHVPGADFLHVFTLRLHCGPARNAKLVEALFNSNSSC


uniprotID: A8MPS7
geneSymbol: YDJC
name: Carbohydrate deacetylase (EC 3.5.1.-)
length: 323
go: ENSG00000161179;
snps: rs2298428
sequence:

opentargets:
hydrolase activity [GO:0016787]; magnesium ion binding [GO:0000287]; carbohydrate metabolic process [GO:0005975]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A8MPS7-1; Sequence=Displayed; Name=2; IsoId=A8MPS7-2; Sequence=VSP_032786, VSP_032787; Name=3; IsoId=A8MPS7-3; Sequence=VSP_032784, VSP_032785; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q6ZS46
name: Putative uncharacterized protein FLJ45840
length: 218
sequence:


uniprotID: Q96MF0
name: Putative uncharacterized protein LOC100506887
length: 132
sequence:
MPFKTKYPNGFHFAYLPTGSTQFRSLLQGQDSASQGVCPCRLCGAVPVRDQARIQSRRITLANCQGQPSALRQVNELANSAQIESFLCFSQLPNAVCFGGHLSCEFRECGYCNINPHHSKQLKLNSVTREES


uniprotID: Q96QA6
geneSymbol: YPEL2
name: Protein yippee-like 2
length: 119
go: ENSG00000175155;
opentargets: nucleolus [GO:0005730]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:15556292}.
sequence:
MVKMTRSKTFQAYLPSCHRTYSCIHCRAHLANHDELISKSFQGSQGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKEGKYIIELAHMIKDNGWD


uniprotID: A8MZ25
name: Putative uncharacterized protein FLJ38767
length: 164
sequence:
MGQKKTMGTERSRGGKRGPQPGAERPEEPGATFSKKPPEGARAPRCLSRPTAPKSGACLARRRPPGSPCSIRDAPFHTGDDRFLARENFPNVLQPLPRMFAVQQAADFESQCPRRWDSRKRPSEGLPSAGWGRWRGRPIHLGLWVSGSVRRKVSGSHVSRSLHL


uniprotID: Q96NJ1
name: Uncharacterized protein FLJ30774
length: 140
sequence:
MRRERPELRDAEGRLRLRAGCLVTAWPRAPSGAGSWSMAAASPWPASWGFPDASSTVPSLCTEARAGRGGPATARSRVSADSQGGRAGSSSPSSALRLCCAGPSQAHPGPSPAVLPGRCGLLGSFPRPPAPQGRWGPSLG


uniprotID: Q6ZQT7
name: Putative uncharacterized protein FLJ44672
length: 251
sequence:


uniprotID: Q9GZM5
geneSymbol: YIPF3
length: 350
go: ENSG00000137207;
snps: rs2231763
name:
Protein YIPF3 (Killer lineage protein 1) (Natural killer cell-specific antigen KLIP1) (YIP1 family member 3) [Cleaved into: Protein YIPF3, 36 kDa form III]

sequence:

opentargets:
Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; transport vesicle [GO:0030133]; cell differentiation [GO:0030154]

location:
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:27999994}; Multi-pass membrane protein. Note=Localization to the cytoplasm or to the cell membrane is developmentally and ontogenetically regulated.


uniprotID: Q96MT0
name: Putative uncharacterized protein FLJ31958
length: 163
sequence:
MFLHSGPARGPCTAAGRSASVRVPVQVAHELQGPDAIVFGAEVEQVHLVANELDAGRVQLLLAQGVAAAVLLVQVVMGEELGEQGHQQARGEVADGQAALLDTAKMLVAEQAVGAGQLQVGLGISNLSKSIGTSQIFLERHRSPLKLSSTLITEMSSGRLEEL


uniprotID: Q6ZVH6
name: Putative uncharacterized protein FLJ42569
length: 145
sequence:
MGPWPRDWLGKGWRLGSCEARAGAKEVSVIRHGAPNPAQSHLHVQARAQVHSEDGHSLPPVVDGEDEVLSLLVFVQDSQECCRQAVQGRQGRGVTWGLGLPSYHLRTLLSPVCVPARDQRAPRKCCEAVLACPLVETLVTTLLTR


uniprotID: Q9BRP9
name: Putative uncharacterized protein MGC13053
length: 147
sequence:
MQPSWTPAPVQRTACNITAWGGEFGKEGEGRCEQVALSSGPPEGALHASREGPQPPGAENLRPSTGETFVQSGRWDGGWRGAMKGRRHRQASTPPTRPESIFVPTAQDGAQMVCKAHTRTTQYTEQDSVVTARGLLDAKRVGVAGGS


uniprotID: A1L4Q6
name: Putative uncharacterized protein FLJ41423
length: 167
sequence:
MAALSSRCPRSAAGPAYLQEAARSAHWASPPLVPLRTFQSSLFSSGSFHSREEEEEGVSLLRTALVGQGPVPLFLGSLFCAGCRQGPSVWSCGEPVPRRIWVTASVTPSPRQALHPCSDSLDILKALHLLPAAFSPFIWVQVFAEPSNKESRGENDGGEERESANIY


uniprotID: Q8IYB0
name: Putative uncharacterized protein MGC39545
length: 196
sequence:
MPSGEERRDRQKGRRAGCDTSSTPSNTAPRIPEPGAHPTAARPATAQPPRSLLPPVCSKTIALPASAAAASGSDTAGMRGLGKAPHSGEGHERGRGNSKMKACNNYQYGYLAKPDTSFWIKCRRWLLADAGRHTQRPFWTFRVSHSPLLEAEAGRPSDVSQLQLGSDLKPKMRRPAGELFSPKDAGWELDPAEKSE


uniprotID: Q3C1V9
name: Putative uncharacterized protein ENSP00000334305
length: 767
sequence:


uniprotID: Q8NA96
name: Putative uncharacterized protein FLJ35723
length: 180
sequence:
MPSSVPKTSIESLGSPSSLSSSQASEPLCPLKHPSHRPPASTLSPNLTSSTESLGYLSSLSSSQPPEPLRPLECPSHKPCGRSLPRRRNPGWVSWSDSMQADSETDAIICPMCKAPERSCPHTWWVPSSPRVIRGVGRCSDPNLGLSWRQEAARAWCHCTSSQYPFKHPNLPTHLPKASF


uniprotID: Q8N7P7
name: Uncharacterized protein FLJ40521
length: 452
sequence:


uniprotID: A8MXE2
length: 369
go: ENSG00000214654;
name:
Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC100288842 (EC 2.4.1.-) (Putative UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase LOC402377) (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 pseudogene)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; acetylgalactosaminyltransferase activity [GO:0008376]; galactosyltransferase activity [GO:0008378]; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity [GO:0008532]; poly-N-acetyllactosamine biosynthetic process [GO:0030311]; protein glycosylation [GO:0006486]


uniprotID: Q6UXR6
name: Putative uncharacterized protein UNQ6494/PRO21346
length: 183
opentargets: extracellular region [GO:0005576]
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MQCWQQPFLRFLQQPFFLATASLAGSSSSFNVLIPKRDEDGDGEGPGDVTAGVSRAAGSPSGWEAPWVQQPRCCRRATPVCCAGQGPPRSLQQGGSEVLLGQLCSPEPDWLPSSGPKVAKQVFQVAAELLQHPEHFVPSSVPEGCVHKPGSTCDGSLKGRAYPSCVPKRDPEHSREESHPLSG


uniprotID: Q96GC6
geneSymbol: ZNF274
reactome: R-HSA-212436;
length: 653
go: ENSG00000171606;
snps: rs7256349
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000269|PubMed:10777669}.
name:
Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleolus [GO:0005730]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; transcription corepressor activity [GO:0003714]; regulation of histone H3-K9 trimethylation [GO:1900112]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Comment=Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=SP2114a; IsoId=Q96GC6-1; Sequence=Displayed; Name=2; Synonyms=ZNF274a; IsoId=Q96GC6-2; Sequence=VSP_006911; Name=3; Synonyms=ZNF274b; IsoId=Q96GC6-3; Sequence=VSP_006910; Name=4; Synonyms=SP2114b; IsoId=Q96GC6-4; Sequence=VSP_006912, VSP_006913; 


uniprotID: Q7Z3V5
geneSymbol: ZNF571
reactome: R-HSA-212436;
name: Zinc finger protein 571
length: 609
go: ENSG00000180479;
snps: rs16973893 rs8111790 rs28512414 rs4802029 rs16973890
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9P1Z0
geneSymbol: ZBTB4
name: Zinc finger and BTB domain-containing protein 4 (KAISO-like zinc finger protein 1) (KAISO-L1)
length: 1013
go: ENSG00000174282;
snps: rs35231078 rs871990 rs34914463
sequence:

opentargets:
chromosome [GO:0005694]; cytosol [GO:0005829]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001227]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; methyl-CpNpG binding [GO:0010428]; protein homodimerization activity [GO:0042803]; protein kinase binding [GO:0019901]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of transcription, DNA-templated [GO:0006355]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16354688}. Chromosome {ECO:0000269|PubMed:16354688}. Note=Localizes to chromocenters. {ECO:0000269|PubMed:16354688}.


uniprotID: Q86SH2
geneSymbol: ZAR1
name: Zygote arrest protein 1 (Oocyte-specific maternal effect factor)
length: 424
go: ENSG00000182223;
opentargets: cytoplasm [GO:0005737]; multicellular organism development [GO:0007275]
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:


uniprotID: Q6FIF0
geneSymbol: ZFAND6
reactome: R-HSA-9033241;
length: 208
go: ENSG00000086666;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
name:
AN1-type zinc finger protein 6 (Associated with PRK1 protein) (Zinc finger A20 domain-containing protein 3)

sequence:

opentargets:
cytosol [GO:0005829]; DNA binding [GO:0003677]; polyubiquitin modification-dependent protein binding [GO:0031593]; zinc ion binding [GO:0008270]; apoptotic process [GO:0006915]; cellular response to tumor necrosis factor [GO:0071356]; negative regulation of apoptotic process [GO:0043066]; protein targeting to peroxisome [GO:0006625]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6FIF0-1; Sequence=Displayed; Name=2; IsoId=Q6FIF0-2; Sequence=VSP_019652; Note=No experimental confirmation available.; 


uniprotID: Q8NHG8
geneSymbol: ZNRF2
reactome: R-HSA-983168;
length: 242
go: ENSG00000180233;
name:
E3 ubiquitin-protein ligase ZNRF2 (EC 2.3.2.27) (Protein Ells2) (RING finger protein 202) (RING-type E3 ubiquitin transferase ZNRF2) (Zinc/RING finger protein 2)

sequence:

opentargets:
cell junction [GO:0030054]; cytoplasm [GO:0005737]; cytoplasmic vesicle membrane [GO:0030659]; cytosol [GO:0005829]; endosome membrane [GO:0010008]; lysosomal membrane [GO:0005765]; plasma membrane [GO:0005886]; presynaptic membrane [GO:0042734]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; protein polyubiquitination [GO:0000209]

location:
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Lysosome membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:14561866}; Peripheral membrane protein {ECO:0000269|PubMed:14561866}. Note=Present in presynaptic plasma membranes in neurons.


uniprotID: Q8NCN2
geneSymbol: ZBTB34
name: Zinc finger and BTB domain-containing protein 34
length: 500
go: ENSG00000177125;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16718364}.
sequence:


uniprotID: Q8NAP3
geneSymbol: ZBTB38
name: Zinc finger and BTB domain-containing protein 38
length: 1195
go: ENSG00000177311;
snps: rs16851435 rs17787670 rs3732867 rs202147729
sequence:

opentargets:
blood microparticle [GO:0072562]; chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; methyl-CpG binding [GO:0008327]; protein homodimerization activity [GO:0042803]; cellular response to DNA damage stimulus [GO:0006974]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of DNA replication [GO:0006275]; regulation of transcription, DNA-templated [GO:0006355]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16354688}. Chromosome {ECO:0000269|PubMed:16354688}. Note=Localizes to chromocenters. {ECO:0000269|PubMed:16354688}.


uniprotID: Q12836
geneSymbol: ZP4
reactome: R-HSA-1300644;
length: 540
go: ENSG00000116996;
snps: rs34370253 rs34811980
name:
Zona pellucida sperm-binding protein 4 (Zona pellucida glycoprotein 4) (Zp-4) (Zona pellucida protein B) [Cleaved into: Processed zona pellucida sperm-binding protein 4]

sequence:

opentargets:
extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; acrosin binding [GO:0032190]; identical protein binding [GO:0042802]; acrosomal vesicle exocytosis [GO:0060478]; binding of sperm to zona pellucida [GO:0007339]; negative regulation of binding of sperm to zona pellucida [GO:2000360]; positive regulation of acrosome reaction [GO:2000344]; positive regulation of humoral immune response [GO:0002922]; positive regulation of T cell proliferation [GO:0042102]

location:
SUBCELLULAR LOCATION: Processed zona pellucida sperm-binding protein 4: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q00193}. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000305}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00193}; Single-pass type I membrane protein {ECO:0000255}.


uniprotID: Q8WWF5
geneSymbol: ZNRF4
length: 429
go: ENSG00000105428;
snps: rs2240743 rs2240744 rs2240745 rs8103406 rs8107825 rs8104246 rs17304380 rs16992985
name:
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21205830}; Single-pass type I membrane protein {ECO:0000305}.


uniprotID: Q86TJ5
geneSymbol: ZNF554
reactome: R-HSA-212436;
name: Zinc finger protein 554
length: 538
snps: rs867168 rs867169
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]


uniprotID: O43829
geneSymbol: ZBTB14
length: 449
go: ENSG00000198081;
snps: rs7235740 rs7235420
name:
Zinc finger and BTB domain-containing protein 14 (Zinc finger protein 161 homolog) (Zfp-161) (Zinc finger protein 478) (Zinc finger protein 5 homolog) (ZF5) (Zfp-5) (hZF5)

sequence:

opentargets:
aggresome [GO:0016235]; cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; sequence-specific DNA binding [GO:0043565]; transcription regulatory region DNA binding [GO:0044212]; cardiac septum development [GO:0003279]; coronary vasculature development [GO:0060976]; heart valve development [GO:0003170]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15629158}. Note=Colocalizes with ZBTB21 in nucleus in HEK293 cells.


uniprotID: Q14966
geneSymbol: ZNF638
reactome: R-HSA-381340;
length: 1978
go: ENSG00000075292;
snps: rs12612365 rs3732235 rs10427371 rs1804020 rs11542286
name:
Zinc finger protein 638 (Cutaneous T-cell lymphoma-associated antigen se33-1) (CTCL-associated antigen se33-1) (Nuclear protein 220) (Zinc finger matrin-like protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; double-stranded DNA binding [GO:0003690]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=Alpha; IsoId=Q14966-1; Sequence=Displayed; Name=2; IsoId=Q14966-2; Sequence=VSP_014802, VSP_014803; Note=No experimental confirmation available.; Name=3; IsoId=Q14966-3; Sequence=VSP_014806; Note=No experimental confirmation available.; Name=4; IsoId=Q14966-4; Sequence=VSP_014804, VSP_014805; Name=5; IsoId=Q14966-5; Sequence=VSP_014801; Note=Broadly expressed.; Name=6; IsoId=Q14966-6; Sequence=VSP_059342, VSP_059343; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:11813260, ECO:0000269|PubMed:8647861}.


uniprotID: Q9ULJ6
geneSymbol: ZMIZ1
pdb: 5AIZ;
length: 1067
go: ENSG00000108175;
name:
Zinc finger MIZ domain-containing protein 1 (PIAS-like protein Zimp10) (Retinoic acid-induced protein 17)

sequence:

opentargets:
cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; zinc ion binding [GO:0008270]; artery morphogenesis [GO:0048844]; cell aging [GO:0007569]; developmental growth [GO:0048589]; heart morphogenesis [GO:0003007]; in utero embryonic development [GO:0001701]; positive regulation of fibroblast proliferation [GO:0048146]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of T cell differentiation [GO:0045582]; positive regulation of transcription by RNA polymerase II [GO:0045944]; vasculogenesis [GO:0001570]; vitellogenesis [GO:0007296]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULJ6-1; Sequence=Displayed; Name=2; IsoId=Q9ULJ6-2; Sequence=VSP_012185, VSP_012186; Note=Incomplete sequence. No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:14609956}. Cytoplasm {ECO:0000269|PubMed:14609956}.


uniprotID: P52742
geneSymbol: ZNF135
reactome: R-HSA-212436;
name: Zinc finger protein 135 (Zinc finger protein 61) (Zinc finger protein 78-like 1)
length: 658
go: ENSG00000176293;
snps: rs1469087 rs2228277 rs2228278 rs2228279 rs2228275
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription, DNA-templated [GO:0006355]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P52742-1; Sequence=Displayed; Name=2; IsoId=P52742-2; Sequence=VSP_046073, VSP_046074; Note=No experimental confirmation available.; Name=3; IsoId=P52742-3; Sequence=VSP_046706; Note=No experimental confirmation available. May be due to competing acceptor splice site.; Name=4; IsoId=P52742-4; Sequence=VSP_046073, VSP_046706; Note=Gene prediction based on EST data.; 


uniprotID: Q96FA7
geneSymbol: ZBED6CL
name: ZBED6 C-terminal-like protein
length: 236
go: ENSG00000188707;
sequence:


uniprotID: Q9BS34
geneSymbol: ZNF670
reactome: R-HSA-212436;
name: Zinc finger protein 670
length: 389
go: ENSG00000277462;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: P0CJ79
geneSymbol: ZNF888
name: Zinc finger protein 888
length: 718
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: Q15940
geneSymbol: ZNF726P1
reactome: R-HSA-212436;
name: Putative zinc finger protein 726P1
length: 193
opentargets: metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]
sequence:
MLSHKTQHKSIYTREKSYKCKKCGKTFNWSSILTNNKKIHTEQKPYKCEECGKAFKQHSTLTTHKIICAEEKLYRCEECGKAFCQPSTLTRYKRMHRRKKLYKCEECGKAFTQFSTLTKHKRIHTRGKHYKCEESGKAFIWSSGLTEHRRVHTRQKPYKCEECGKALIQFSTLTRHKRIHTGEKPNKSMWQTF


uniprotID: Q5T1R4
geneSymbol: HIVEP3
reactome: R-HSA-8939902;
length: 2406
go: ENSG00000127124;
snps: rs2146315 rs780211835 rs2810566 rs17363472 rs2483689 rs2991344 rs11809423 rs9439043
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
name:
Transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3) (Kappa-B and V(D)J recombination signal sequences-binding protein) (Kappa-binding protein 1) (KBP-1) (Zinc finger protein ZAS3)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; positive regulation of transcription, DNA-templated [GO:0045893]; skeletal muscle cell differentiation [GO:0035914]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Comment=Additional isoforms can be generated by alternative splicing or polyadenylation. HIVEP3L transcript may lack exon 7 leading to a premature codon stop. {ECO:0000269|PubMed:11161801}; Name=1; Synonyms=HIVEP3S; IsoId=Q5T1R4-1; Sequence=Displayed; Name=2; IsoId=Q5T1R4-2; Sequence=VSP_033279; 


uniprotID: Q5EBL2
geneSymbol: ZNF628
name: Zinc finger protein 628
length: 1059
go: ENSG00000197483;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: Q8N966
geneSymbol: ZDHHC22
length: 263
go: ENSG00000177108;
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
name:
Palmitoyltransferase ZDHHC22 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 22) (DHHC-22) (zDHHC22)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; Golgi apparatus [GO:0005794]; integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; protein-cysteine S-palmitoyltransferase activity [GO:0019706]; peptidyl-L-cysteine S-palmitoylation [GO:0018230]; protein localization to plasma membrane [GO:0072659]; protein palmitoylation [GO:0018345]; protein targeting to membrane [GO:0006612]


uniprotID: Q96JF6
geneSymbol: ZNF594
name: Zinc finger protein 594 (Zinc finger protein HZF18)
length: 807
go: ENSG00000180626;
snps: rs59197486 rs9908414 rs3853648
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]


uniprotID: Q68DY9
geneSymbol: ZNF772
reactome: R-HSA-212436;
name: Zinc finger protein 772
length: 489
go: ENSG00000197128;
snps: rs2074060 rs2074059
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q68DY9-1; Sequence=Displayed; Name=2; IsoId=Q68DY9-2; Sequence=VSP_021882; Name=3; IsoId=Q68DY9-3; Sequence=VSP_043423; Note=No experimental confirmation available.; 


uniprotID: Q6NX45
geneSymbol: ZNF774
reactome: R-HSA-212436;
name: Zinc finger protein 774
length: 483
go: ENSG00000196391;
snps: rs16944267 rs2589957 rs11854320
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: A8MT70
geneSymbol: ZBBX
name: Zinc finger B-box domain-containing protein 1
length: 800
go: ENSG00000169064;
opentargets: intracellular [GO:0005622]; zinc ion binding [GO:0008270]
snps: rs10936535 rs4619784 rs11923054 rs34465133 rs13096767 rs35190925 rs35864545 rs12638625
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=A8MT70-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=3; IsoId=A8MT70-3; Sequence=VSP_054851; Note=No experimental confirmation available.; Name=2; IsoId=A8MT70-2; Sequence=VSP_035573; Note=No experimental confirmation available.; 


uniprotID: Q96KR1
geneSymbol: ZFR
name: Zinc finger RNA-binding protein (hZFR) (M-phase phosphoprotein homolog)
length: 1074
go: ENSG00000056097;
snps: rs587777203 rs4867440 rs1051489
sequence:

opentargets:
chromosome [GO:0005694]; cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA binding [GO:0003677]; double-stranded RNA binding [GO:0003725]; RNA binding [GO:0003723]; single-stranded RNA binding [GO:0003727]; zinc ion binding [GO:0008270]; multicellular organism development [GO:0007275]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associated with chromosome foci in meiotic cells. Localizes in somatodendritic compartment of primary hippocampal neurons. Colocalizes with STAU2 in several cytosolic RNA granules (By similarity). {ECO:0000250}.


uniprotID: Q8NE65
geneSymbol: ZNF738
reactome: R-HSA-212436;
name: Protein ZNF738
length: 137
go: ENSG00000172687;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:
MDDLRYGVYPVKGASGYPGAERNLLEYSYFEKGPLTFRDVVIEFSQEEWQCLDTAQQDLYRKVMLENFRNLVFLGIDVSKPDLITCLEQGKDPWNMKRHSMVATPPESGVLKFPTIIILLSRCFFQSVNICFIYLEP

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; ubiquitin-protein transferase activity [GO:0004842]; protein polyubiquitination [GO:0000209]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: P98169
geneSymbol: ZXDB
name: Zinc finger X-linked protein ZXDB
length: 803
go: ENSG00000198455;
snps: rs1057338 rs1057340 rs1057341 rs1057343
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q6NUN9
geneSymbol: ZNF746
reactome: R-HSA-212436;
name: Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)
length: 644
go: ENSG00000181220;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific [GO:0001078]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; transcription regulatory region DNA binding [GO:0044212]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of neuron death [GO:1901216]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q6NUN9-1; Sequence=Displayed; Name=2; IsoId=Q6NUN9-2; Sequence=VSP_041053; Note=No experimental confirmation available.; Name=3; IsoId=Q6NUN9-3; Sequence=VSP_041052; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21376232}. Nucleus {ECO:0000305|PubMed:21376232}. Note=Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.


uniprotID: Q96AP4
geneSymbol: ZUP1
pdb: 6EI1;6FGE;
length: 578
go: ENSG00000153975;
snps: rs4946188
name:
Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; thiol-dependent ubiquitinyl hydrolase activity [GO:0036459]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96AP4-1; Sequence=Displayed; Name=2; IsoId=Q96AP4-2; Sequence=VSP_019533; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29476094}. Nucleus {ECO:0000269|PubMed:29476094, ECO:0000269|PubMed:29576527, ECO:0000269|PubMed:29576528}. Note=Mostly present in the nuclear fraction. Localizes to DNA lesions. {ECO:0000269|PubMed:29576527, ECO:0000269|PubMed:29576528}.


uniprotID: Q86W11
geneSymbol: ZSCAN30
length: 494
go: ENSG00000186814;
snps: rs2249769
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger and SCAN domain-containing protein 30 (ZNF-WYM) (Zinc finger protein 397 opposite strand) (Zinc finger protein 397OS)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q86W11-1; Sequence=Displayed; Name=2; IsoId=Q86W11-3; Sequence=VSP_027861, VSP_027862; Note=No experimental confirmation available.; 


uniprotID: Q8TF50
geneSymbol: ZNF526
name: Zinc finger protein 526
length: 670
go: ENSG00000167625;
snps: rs3810151 rs17850994
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8N823
geneSymbol: ZNF611
reactome: R-HSA-212436;
name: Zinc finger protein 611
length: 705
go: ENSG00000213020;
snps: rs3884051 rs34846371 rs4085566 rs4085565 rs4087790
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N823-1; Sequence=Displayed; Name=2; IsoId=Q8N823-2; Sequence=VSP_038425; 


uniprotID: Q8NDQ6
geneSymbol: ZNF540
reactome: R-HSA-212436;
name: Zinc finger protein 540
length: 660
go: ENSG00000171817;
snps: rs1975937 rs571893947
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; translation repressor activity, mRNA regulatory element binding [GO:0000900]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of translation [GO:0017148]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8NDQ6-1; Sequence=Displayed; Name=2; IsoId=Q8NDQ6-2; Sequence=VSP_016037; Note=No experimental confirmation available.; Name=4; IsoId=Q8NDQ6-4; Sequence=VSP_016036; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16815308}. Cytoplasm {ECO:0000269|PubMed:16815308}.


uniprotID: Q8NAF0
geneSymbol: ZNF579
name: Zinc finger protein 579
length: 562
go: ENSG00000218891;
snps: rs10403008
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]


uniprotID: Q8N2I2
geneSymbol: ZNF619
reactome: R-HSA-212436;
name: Zinc finger protein 619
length: 560
go: ENSG00000177873;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q8N2I2-1; Sequence=Displayed; Name=2; IsoId=Q8N2I2-2; Sequence=VSP_043080; Note=No experimental confirmation available.; Name=3; IsoId=Q8N2I2-3; Sequence=VSP_055715; Note=Gene prediction based on EST data.; Name=4; IsoId=Q8N2I2-4; Sequence=VSP_055716; Note=Gene prediction based on EST data.; 


uniprotID: Q969J2
geneSymbol: ZKSCAN4
reactome: R-HSA-212436;
length: 545
go: ENSG00000187626;
snps: rs9986596
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187, ECO:0000269|PubMed:17910948}.
name:
Zinc finger protein with KRAB and SCAN domains 4 (P373c6.1) (Zinc finger protein 307) (Zinc finger protein 427)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]


uniprotID: Q6P9A3
geneSymbol: ZNF549
reactome: R-HSA-212436;
name: Zinc finger protein 549
length: 640
snps: rs12461014
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6P9A3-1; Sequence=Displayed; Name=2; IsoId=Q6P9A3-2; Sequence=VSP_018379; Note=No experimental confirmation available.; 


uniprotID: P0C7X5
geneSymbol: ZNF806
name: Zinc finger protein 806
length: 589
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

snps:
rs2459647 rs7340197 rs7355766 rs4953961 rs7355689 rs7349198 rs7349364 rs7349365 rs7349446 rs7349215 rs7349216 rs7340191 rs7340499 rs2598810 rs2598809 rs2677622 rs2598807 rs7340213 rs2598806 


uniprotID: Q9HCK1
geneSymbol: ZDBF2
name: DBF4-type zinc finger-containing protein 2
length: 2354
go: ENSG00000204186;
opentargets: nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]
snps: rs10932150
sequence:


uniprotID: Q9BS86
geneSymbol: ZPBP
name: Zona pellucida-binding protein 1 (Inner acrosomal membrane IAM38) (Sp38)
length: 351
go: ENSG00000042813;
snps: rs202231065 rs61696422 rs1299521157 rs1468321681
sequence:

opentargets:
acrosomal membrane [GO:0002080]; extracellular region [GO:0005576]; nucleus [GO:0005634]; binding of sperm to zona pellucida [GO:0007339]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BS86-1; Sequence=Displayed; Name=2; IsoId=Q9BS86-2; Sequence=VSP_045491; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q62522}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62522}. Secreted {ECO:0000305}. Note=First localized in acrosome granule, later migrates to the inner and outer acrosomal membrane. Released after the acrosomal reaction. {ECO:0000250|UniProtKB:Q62522}.


uniprotID: Q96C28
geneSymbol: ZNF707
reactome: R-HSA-212436;
name: Zinc finger protein 707
length: 371
go: ENSG00000181135;
snps: rs6987308
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q5SVZ6
geneSymbol: ZMYM1
name: Zinc finger MYM-type protein 1
length: 1142
go: ENSG00000197056;
snps: rs2971408 rs7552714 rs16837197
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; protein dimerization activity [GO:0046983]; zinc ion binding [GO:0008270]; cytoskeleton organization [GO:0007010]; regulation of cell morphogenesis [GO:0022604]; regulation of transcription by RNA polymerase II [GO:0006357]


uniprotID: O00488
geneSymbol: ZNF593
pdb: 1ZR9;
name: Zinc finger protein 593 (Zinc finger protein T86)
length: 134
go: ENSG00000142684;
snps: rs2232649
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:
MGRSRRTGAHRAHSLARQMKAKRRRPDLDEIHRELRPQGSARPQPDPNAEFDPDLPGGGLHRCLACARYFIDSTNLKTHFRSKDHKKRLKQLSVEPYSQEEAERAAGMGSYVPPRRLAVPTEVSTEVPEMDTST

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; ribosomal large subunit binding [GO:0043023]; zinc ion binding [GO:0008270]; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [GO:1903026]; positive regulation of transcription by RNA polymerase II [GO:0045944]; ribosomal large subunit export from nucleus [GO:0000055]


uniprotID: Q6ZNA1
geneSymbol: ZNF836
name: Zinc finger protein 836
length: 936
go: ENSG00000196267;
snps: rs1366245 rs8113504
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9NTW7
geneSymbol: ZFP64
name: Zinc finger protein 64 homolog, isoforms 3 and 4 (Zfp-64) (Zinc finger protein 338)
length: 645
go: ENSG00000020256;
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=3; IsoId=Q9NTW7-1; Sequence=Displayed; Name=4; Synonyms=ZNF338; IsoId=Q9NTW7-2; Sequence=VSP_007285, VSP_007286; Name=1; IsoId=Q9NPA5-1; Sequence=External; Name=2; IsoId=Q9NPA5-2; Sequence=External; Name=5; IsoId=Q9NTW7-3; Sequence=VSP_038213, VSP_038214; Name=6; IsoId=Q9NTW7-4; Sequence=VSP_046896, VSP_046897, VSP_046898; Note=Gene prediction based on EST data. {ECO:0000244|PubMed:23186163, ECO:0000244|PubMed:28112733}; 


uniprotID: Q5HYK9
geneSymbol: ZNF667
reactome: R-HSA-212436;
name: Zinc finger protein 667
length: 610
go: ENSG00000198046;
snps: rs35914474 rs3760849 rs12610019
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q6P280
geneSymbol: ZNF529
reactome: R-HSA-212436;
name: Zinc finger protein 529
length: 563
go: ENSG00000186020;
snps: rs2912444
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: O43345
geneSymbol: ZNF208
reactome: R-HSA-212436;
name: Zinc finger protein 208 (Zinc finger protein 91-like)
length: 1280
go: ENSG00000160321;
snps: rs2007506 rs12462668 rs7255075 rs10425763 rs8108957
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O43345-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=O43345-2; Sequence=VSP_053780, VSP_053781, VSP_053782; Note=No experimental confirmation available.; 


uniprotID: P0CJ78
geneSymbol: ZNF865
name: Zinc finger protein 865
length: 1059
go: ENSG00000261221;
opentargets: nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: A6NP11
geneSymbol: ZNF716
reactome: R-HSA-212436;
name: Zinc finger protein 716
length: 495
go: ENSG00000182111;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q2M3X9
geneSymbol: ZNF674
name: Zinc finger protein 674
length: 581
go: ENSG00000251192;
snps: rs1737367 rs61730637 rs1422964788
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q2M3X9-1; Sequence=Displayed; Name=2; IsoId=Q2M3X9-2; Sequence=VSP_044562; Note=No experimental confirmation available.; 


uniprotID: Q8NCK3
geneSymbol: ZNF485
reactome: R-HSA-212436;
name: Zinc finger protein 485
length: 441
go: ENSG00000198298;
snps: rs12354886
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; sequence-specific DNA binding [GO:0043565]; negative regulation of transcription, DNA-templated [GO:0045892]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NCK3-1; Sequence=Displayed; Name=2; IsoId=Q8NCK3-2; Sequence=VSP_055957; Note=No experimental confirmation available.; 


uniprotID: B1APH4
geneSymbol: ZNF487
name: Putative zinc finger protein 487 (KRAB domain only protein 1)
length: 448
go: ENSG00000243660;
snps: rs11816311 rs11598660
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=B1APH4-1; Sequence=Displayed; Name=2; IsoId=B1APH4-2; Sequence=VSP_055958, VSP_055959, VSP_055960; Note=No experimental confirmation available.; 


uniprotID: Q9H707
geneSymbol: ZNF552
reactome: R-HSA-212436;
name: Zinc finger protein 552
length: 407
go: ENSG00000178935;
snps: rs2288538
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9Y5V0
geneSymbol: ZNF706
reactome: R-HSA-212436;
name: Zinc finger protein 706
sequence: MARGQQKIQSQQKNAKKQAGQKKKQGHDQKAAAKAALIYTCTVCRTQMPDPKTFKQHFESKHPKTPLPPELADVQA
length: 76
go: ENSG00000120963;
opentargets:
cytoplasm [GO:0005737]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; negative regulation of stem cell population maintenance [GO:1902455]; negative regulation of transcription, DNA-templated [GO:0045892]; regulation of translation [GO:0006417]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D115}. Nucleus {ECO:0000250|UniProtKB:Q9D115}.


uniprotID: Q8N8C0
geneSymbol: ZNF781
name: Zinc finger protein 781
length: 355
go: ENSG00000196381;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N8C0-1; Sequence=Displayed; Name=2; IsoId=Q8N8C0-2; Sequence=VSP_026560; Note=No experimental confirmation available.; 


uniprotID: Q13398
geneSymbol: ZNF211
reactome: R-HSA-212436;
name: Zinc finger protein 211 (Zinc finger protein C2H2-25)
length: 564
go: ENSG00000121417;
snps: rs34897843 rs11879465
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=1; IsoId=Q13398-1; Sequence=Displayed; Name=2; IsoId=Q13398-2; Sequence=VSP_035702; Name=3; IsoId=Q13398-3; Sequence=VSP_035704; Name=4; IsoId=Q13398-4; Sequence=VSP_035705; Note=No experimental confirmation available.; Name=5; IsoId=Q13398-5; Sequence=VSP_035703; Name=6; IsoId=Q13398-6; Sequence=VSP_035706; Name=7; IsoId=Q13398-7; Sequence=VSP_045643; Note=No experimental confirmation available.; Name=8; IsoId=Q13398-8; Sequence=VSP_045643, VSP_046769; Note=Gene prediction based on EST data.; 


uniprotID: Q8IVC4
geneSymbol: ZNF584
reactome: R-HSA-212436;
name: Zinc finger protein 584
length: 421
go: ENSG00000171574;
snps: rs11668789 rs7257872
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9BQ24
geneSymbol: ZFYVE21
pdb: 2RRF;
name: Zinc finger FYVE domain-containing protein 21 (ZF21)
length: 234
go: ENSG00000100711;
opentargets: endosome [GO:0005768]; focal adhesion [GO:0005925]; metal ion binding [GO:0046872]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BQ24-1; Sequence=Displayed; Name=2; IsoId=Q9BQ24-2; Sequence=VSP_013794; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cytoplasmic vesicle. Endosome. Note=Within cytoplasmic vesicles, partially colocalizes with EEA1, an endosomal marker.


uniprotID: O43257
geneSymbol: ZNHIT1
length: 154
go: ENSG00000106400;
snps: rs369664812
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17892483}.
name:
Zinc finger HIT domain-containing protein 1 (Cyclin-G1-binding protein 1) (Zinc finger protein subfamily 4A member 1) (p18 Hamlet)

sequence:
MVEKKTSVRSQDPGQRRVLDRAARQRRINRQLEALENDNFQDDPHAGLPQLGKRLPQFDDDADTGKKKKKTRGDHFKLRFRKNFQALLEEQNLSVAEGPNYLTACAGPPSRPQRPFCAVCGFPSPYTCVSCGARYCTVRCLGTHQETRCLKWTV

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; Swr1 complex [GO:0000812]; histone deacetylase binding [GO:0042826]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; histone exchange [GO:0043486]; regulation of histone deacetylation [GO:0031063]


uniprotID: Q96JG9
geneSymbol: ZNF469
name: Zinc finger protein 469
length: 3925
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

snps:
rs11648572 rs11640794 rs7197071 rs4782300 rs13334190 rs12598474 rs3812956 rs3812955 rs3812954 rs1983014 rs1105066 rs904783 


uniprotID: Q9BWM5
geneSymbol: ZNF416
reactome: R-HSA-212436;
name: Zinc finger protein 416
length: 594
go: ENSG00000083817;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q8WTR7
geneSymbol: ZNF473
reactome: R-HSA-109688;R-HSA-111367;R-HSA-212436;R-HSA-77588;
pdb: 2EMB;2EMC;2EME;2EOU;2EOX;2EOY;2EOZ;2YRH;2YRJ;2YSV;2YTD;2YTE;2YTT;2YU5;
name: Zinc finger protein 473 (Zinc finger protein 100 homolog) (Zfp-100)
length: 871
go: ENSG00000142528;
snps: rs10419876 rs10419911 rs16981705 rs16981706 rs10424809 rs10426374
sequence:

opentargets:
Cajal body [GO:0015030]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; metal ion binding [GO:0046872]; histone mRNA metabolic process [GO:0008334]; mRNA 3'-end processing by stem-loop binding and cleavage [GO:0006398]; regulation of transcription, DNA-templated [GO:0006355]; termination of RNA polymerase II transcription [GO:0006369]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16714279}. Note=Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.


uniprotID: Q96HQ0
geneSymbol: ZNF419
reactome: R-HSA-212436;
name: Zinc finger protein 419
length: 510
go: ENSG00000105136;
snps: rs2074076 rs2074077
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q96HQ0-1; Sequence=Displayed; Name=2; IsoId=Q96HQ0-2; Sequence=VSP_016034, VSP_016033; Note=No experimental confirmation available.; Name=3; IsoId=Q96HQ0-3; Sequence=VSP_046149; Note=No experimental confirmation available.; Name=4; IsoId=Q96HQ0-4; Sequence=VSP_047106; Note=No experimental confirmation available.; Name=5; IsoId=Q96HQ0-5; Sequence=VSP_016034; Note=No experimental confirmation available.; Name=6; IsoId=Q96HQ0-6; Sequence=VSP_046149, VSP_016033; 


uniprotID: Q9H0D2
geneSymbol: ZNF541
name: Zinc finger protein 541
length: 1346
go: ENSG00000118156;
snps: rs3810320 rs34984302 rs3826835
sequence:

opentargets:
histone deacetylase complex [GO:0000118]; nucleus [GO:0005634]; transcription factor complex [GO:0005667]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription factor binding [GO:0008134]; transcription regulatory region DNA binding [GO:0044212]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=3; IsoId=Q9H0D2-3; Sequence=Displayed; Note=No experimental confirmation available. Based on EST data and partial nucleotide sequence.; Name=2; IsoId=Q9H0D2-2; Sequence=VSP_016024; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q0GGX2, ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}.


uniprotID: A8MT65
geneSymbol: ZNF891
name: Zinc finger protein 891
length: 544
go: ENSG00000214029;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: P17010
geneSymbol: ZFX
name: Zinc finger X-chromosomal protein
length: 805
go: ENSG00000005889;
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; transcription coactivator activity [GO:0003713]; fertilization [GO:0009566]; homeostasis of number of cells [GO:0048872]; multicellular organism growth [GO:0035264]; oocyte development [GO:0048599]; ovarian follicle development [GO:0001541]; parental behavior [GO:0060746]; post-embryonic development [GO:0009791]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P17010-1; Sequence=Displayed; Name=2; IsoId=P17010-2; Sequence=VSP_014371; Name=3; IsoId=P17010-3; Sequence=VSP_054512; Note=No experimental confirmation available.; 


uniprotID: B4DX44
geneSymbol: ZNF736
reactome: R-HSA-212436;
name: Zinc finger protein 736
length: 427
go: ENSG00000234444;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:


uniprotID: Q8NEK5
geneSymbol: ZNF548
reactome: R-HSA-212436;
name: Zinc finger protein 548
length: 533
go: ENSG00000188785;
snps: rs17856896 rs4801478
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8NEK5-1; Sequence=Displayed; Name=2; IsoId=Q8NEK5-2; Sequence=VSP_019453; Note=No experimental confirmation available.; 


uniprotID: Q9UK11
geneSymbol: ZNF223
reactome: R-HSA-212436;
name: Zinc finger protein 223
length: 482
go: ENSG00000178386;
snps: rs4130101 rs6509138
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q96N22
geneSymbol: ZNF681
reactome: R-HSA-212436;
name: Zinc finger protein 681
length: 645
go: ENSG00000196172;
snps: rs7248674 rs1818989 rs1818990 rs1852433
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96N22-1; Sequence=Displayed; Name=2; IsoId=Q96N22-2; Sequence=VSP_039878; 


uniprotID: Q9P255
geneSymbol: ZNF492
reactome: R-HSA-212436;
name: Zinc finger protein 492 (Zinc finger protein 115)
length: 531
go: ENSG00000229676;
snps: rs11672238
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q0IIN9
geneSymbol: ZNF252P-AS1
length: 211
snps: rs2294043
name:
Putative uncharacterized protein ZNF252P-AS1 (ZNF252P antisense RNA 1) (ZNF252P antisense gene protein 1)

sequence:


uniprotID: P17039
geneSymbol: ZNF30
reactome: R-HSA-212436;
name: Zinc finger protein 30 (Zinc finger protein KOX28)
length: 623
go: ENSG00000168661;
snps: rs1811 rs8100497 rs1345658 rs765746
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P17039-1; Sequence=Displayed; Name=2; IsoId=P17039-2; Sequence=VSP_040942; Name=3; IsoId=P17039-3; Sequence=VSP_040943, VSP_040944; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 


uniprotID: Q8N567
geneSymbol: ZCCHC9
name: Zinc finger CCHC domain-containing protein 9
length: 271
go: ENSG00000131732;
snps: rs16878594
sequence:

opentargets:
nucleolus [GO:0005730]; RNA binding [GO:0003723]; zinc ion binding [GO:0008270]; negative regulation of phosphatase activity [GO:0010923]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18721783}. Nucleus {ECO:0000269|PubMed:18721783}. Note=Expressed throughout the nucleus and concentrated mainly in the nucleolus. {ECO:0000269|PubMed:18721783}.


uniprotID: P52747
geneSymbol: ZNF143
reactome: R-HSA-6807505;R-HSA-749476;R-HSA-76071;
length: 638
go: ENSG00000166478;
snps: rs34972213 rs10743108
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Zinc finger protein 143 (SPH-binding factor) (Selenocysteine tRNA gene transcription-activating factor) (hStaf)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001077]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of transcription by RNA polymerase II [GO:0006357]; regulation of transcription by RNA polymerase III [GO:0006359]; regulation of transcription, DNA-templated [GO:0006355]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P52747-1; Sequence=Displayed; Name=2; IsoId=P52747-2; Sequence=VSP_036978; Name=3; IsoId=P52747-3; Sequence=VSP_055109; Note=No experimental confirmation available.; 


uniprotID: P17014
geneSymbol: ZNF12
reactome: R-HSA-212436;
length: 697
go: ENSG00000164631;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16806083}.
name:
Zinc finger protein 12 (Gonadotropin-inducible ovary transcription repressor 3) (GIOT-3) (Zinc finger protein 325) (Zinc finger protein KOX3)

sequence:

opentargets:
centrosome [GO:0005813]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; negative regulation of transcription, DNA-templated [GO:0045892]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P17014-1; Sequence=Displayed; Name=2; IsoId=P17014-2; Sequence=VSP_040335; Name=3; IsoId=P17014-3; Sequence=VSP_040334; Name=4; IsoId=P17014-4; Sequence=VSP_040738, VSP_040739; Name=5; IsoId=P17014-5; Sequence=VSP_040739; 


uniprotID: Q5D1E8
geneSymbol: ZC3H12A
pdb: 3V32;3V33;3V34;
length: 599
go: ENSG00000163874;
snps: rs16824179 rs17849897
name:
Endoribonuclease ZC3H12A (EC 3.1.-.-) (Monocyte chemotactic protein-induced protein 1) (MCP-induced protein 1) (MCPIP-1) (Regnase-1) (Reg1) (Zinc finger CCCH domain-containing protein 12A)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytoskeleton [GO:0005856]; extrinsic component of endoplasmic reticulum membrane [GO:0042406]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; protein-containing complex [GO:0032991]; rough endoplasmic reticulum [GO:0005791]; rough endoplasmic reticulum membrane [GO:0030867]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; endoribonuclease activity [GO:0004521]; exoribonuclease activity [GO:0004532]; metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; mRNA 3'-UTR AU-rich region binding [GO:0035925]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; ribonuclease activity [GO:0004540]; ribosome binding [GO:0043022]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; angiogenesis [GO:0001525]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular response to chemokine [GO:1990869]; cellular response to DNA damage stimulus [GO:0006974]; cellular response to glucose starvation [GO:0042149]; cellular response to interleukin-1 [GO:0071347]; cellular response to ionomycin [GO:1904637]; cellular response to lipopolysaccharide [GO:0071222]; cellular response to oxidative stress [GO:0034599]; cellular response to sodium arsenite [GO:1903936]; cellular response to tumor necrosis factor [GO:0071356]; cellular response to virus [GO:0098586]; defense response to virus [GO:0051607]; immune response-activating signal transduction [GO:0002757]; inflammatory response [GO:0006954]; negative regulation by host of viral genome replication [GO:0044828]; negative regulation of cardiac muscle contraction [GO:0055118]; negative regulation of cytokine production involved in inflammatory response [GO:1900016]; negative regulation of gene expression [GO:0010629]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of interferon-gamma secretion [GO:1902714]; negative regulation of interleukin-1 beta secretion [GO:0050713]; negative regulation of interleukin-6 production [GO:0032715]; negative regulation of interleukin-6 secretion [GO:1900165]; negative regulation of macrophage activation [GO:0043031]; negative regulation of muscle cell apoptotic process [GO:0010656]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of NIK/NF-kappaB signaling [GO:1901223]; negative regulation of nitric oxide biosynthetic process [GO:0045019]; negative regulation of production of miRNAs involved in gene silencing by miRNA [GO:1903799]; negative regulation of protein phosphorylation [GO:0001933]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of tumor necrosis factor production [GO:0032720]; negative regulation of tumor necrosis factor secretion [GO:1904468]; nervous system development [GO:0007399]; nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay [GO:0000294]; positive regulation of angiogenesis [GO:0045766]; positive regulation of autophagy [GO:0010508]; positive regulation of cell death [GO:0010942]; positive regulation of defense response to virus by host [GO:0002230]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of execution phase of apoptosis [GO:1900119]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of gene expression [GO:0010628]; positive regulation of lipid storage [GO:0010884]; positive regulation of miRNA catabolic process [GO:2000627]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of p38MAPK cascade [GO:1900745]; positive regulation of protein deubiquitination [GO:1903003]; positive regulation of protein import into nucleus [GO:0042307]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein complex oligomerization [GO:0051259]; protein deubiquitination [GO:0016579]; regulation of gene expression [GO:0010468]; RNA phosphodiester bond hydrolysis [GO:0090501]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]; T cell receptor signaling pathway [GO:0050852]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16574901}. Cytoplasm {ECO:0000269|PubMed:18178554, ECO:0000269|PubMed:19909337, ECO:0000269|PubMed:22055188}. Cytoplasm, P-body {ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:26134560}. Rough endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5D1E7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5D1E7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5D1E7}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q5D1E7}. Note=Predominantly localized in the cytoplasm. Colocalizes with GW182 on many granule-like structures, probably corresponding to cytoplasmic GW bodies (GWBs), also called processing bodies (P bodies). Colocalizes with calnexin on the surface of the rough endoplasmic reticulum (RER) membrane and with translationally active polysomes (By similarity). Colocalizes with ZC3H12D in cytoplasmic mRNA processing P-body, also known as GW bodies (GWBs) (PubMed:22055188, PubMed:26134560). {ECO:0000269|PubMed:22055188, ECO:0000269|PubMed:26134560}.


uniprotID: Q86V71
geneSymbol: ZNF429
reactome: R-HSA-212436;
name: Zinc finger protein 429
length: 674
go: ENSG00000197013;
snps: rs2562473
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:


uniprotID: Q9H8G1
geneSymbol: ZNF430
reactome: R-HSA-212436;
name: Zinc finger protein 430
length: 570
go: ENSG00000118620;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; substantia nigra development [GO:0021762]


uniprotID: Q8TF32
geneSymbol: ZNF431
reactome: R-HSA-212436;
name: Zinc finger protein 431
length: 576
go: ENSG00000196705;
snps: rs17445374
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; chromatin binding [GO:0003682]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; metal ion binding [GO:0046872]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; cell differentiation [GO:0030154]; negative regulation of DNA-binding transcription factor activity [GO:0043433]; negative regulation of transcription by RNA polymerase II [GO:0000122]


