# annotation

uniprotID: A6NIZ1
name: Ras-related protein Rap-1b-like protein
length: 184
sequence:
MREYKLVVLGSRGVGKSALTVQFVQGIFVEKYDPTIEDSYREQVEVDAQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSSCQLL

opentargets:
cytosol [GO:0005829]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; Rap protein signal transduction [GO:0032486]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=May shuttle between plasma membrane and cytosol. {ECO:0000250}.


uniprotID: Q8IWN7
geneSymbol: RP1L1
name: Retinitis pigmentosa 1-like 1 protein
length: 2400
go: ENSG00000183638;
sequence:

opentargets:
axoneme [GO:0005930]; microtubule [GO:0005874]; photoreceptor connecting cilium [GO:0032391]; photoreceptor outer segment [GO:0001750]; axoneme assembly [GO:0035082]; intracellular signal transduction [GO:0035556]; photoreceptor cell development [GO:0042461]; photoreceptor cell maintenance [GO:0045494]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]

snps:
rs140397694 rs267607017 rs150931842 rs6601495 rs189960401 rs4388421 rs74400517 rs74990397 rs141846905 rs35602868 rs199746022 rs62490856 rs267607018 rs4840502 rs863225442 rs4840501 rs4240659 rs386722178 rs61503212 rs4840498 rs62490855 rs4841399 rs202068070 rs13267180 rs79019225 rs28446662 rs11785822 rs11783478 rs11778341 rs4354268 rs72494282 rs4354268 rs75797924 rs55642448 rs117007660 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8IWN7-1; Sequence=Displayed; Name=2; IsoId=Q8IWN7-2; Sequence=VSP_009382, VSP_009383; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Note=Localized to the axoneme of outer segments and connecting cilia in rod photoreceptors. {ECO:0000250}.


uniprotID: P53803
geneSymbol: POLR2K
pdb: 5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
sequence: MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR
length: 58
go: ENSG00000147669;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-168325;R-HSA-1834949;R-HSA-203927;R-HSA-427413;R-HSA-452723;R-HSA-5250924;R-HSA-5578749;R-HSA-5601884;R-HSA-5617472;R-HSA-674695;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6796648;R-HSA-6803529;R-HSA-6807505;R-HSA-72086;R-HSA-72163;R-HSA-72165;R-HSA-72203;R-HSA-73762;R-HSA-73772;R-HSA-73776;R-HSA-73777;R-HSA-73779;R-HSA-73780;R-HSA-73863;R-HSA-73980;R-HSA-749476;R-HSA-75953;R-HSA-75955;R-HSA-76042;R-HSA-76061;R-HSA-76066;R-HSA-76071;R-HSA-77075;R-HSA-8851708;R-HSA-9018519;

name:
DNA-directed RNA polymerases I, II, and III subunit RPABC4 (RNA polymerases I, II, and III subunit ABC4) (ABC10-alpha) (DNA-directed RNA polymerase II subunit K) (RNA polymerase II 7.0 kDa subunit) (RPB7.0) (RPB10alpha)

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of gene silencing by miRNA [GO:0060964]; regulation of transcription by RNA polymerase I [GO:0006356]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: P62875
geneSymbol: POLR2L
pdb: 5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
sequence: MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK
length: 67
go: ENSG00000177700;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:9852112}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-168325;R-HSA-1834949;R-HSA-203927;R-HSA-427413;R-HSA-452723;R-HSA-5250924;R-HSA-5578749;R-HSA-5601884;R-HSA-5617472;R-HSA-674695;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6796648;R-HSA-6803529;R-HSA-6807505;R-HSA-72086;R-HSA-72163;R-HSA-72165;R-HSA-72203;R-HSA-73762;R-HSA-73772;R-HSA-73776;R-HSA-73777;R-HSA-73779;R-HSA-73780;R-HSA-73863;R-HSA-73980;R-HSA-749476;R-HSA-75953;R-HSA-75955;R-HSA-76042;R-HSA-76061;R-HSA-76066;R-HSA-76071;R-HSA-77075;R-HSA-8851708;R-HSA-9018519;

name:
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog)

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; zinc ion binding [GO:0008270]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of gene silencing by miRNA [GO:0060964]; regulation of transcription by RNA polymerase I [GO:0006356]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: Q9BWH6
geneSymbol: RPAP1
name: RNA polymerase II-associated protein 1
length: 1393
go: ENSG00000103932;
snps: rs2297382 rs2289741 rs1200345 rs372712659 rs11630901 rs8027526 rs7170898
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9BWH6-1; Sequence=Displayed; Name=2; IsoId=Q9BWH6-2; Sequence=VSP_024680, VSP_024681; Note=No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=Q9BWH6-3; Sequence=VSP_024679; 


uniprotID: Q9Y535
geneSymbol: POLR3H
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 204
go: ENSG00000100413;
location: SUBCELLULAR LOCATION: Nucleus.
name:
DNA-directed RNA polymerase III subunit RPC8 (RNA polymerase III subunit C8) (DNA-directed RNA polymerase III subunit H) (RNA polymerase III subunit 22.9 kDa subunit) (RPC22.9)

sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; nucleobase-containing compound metabolic process [GO:0006139]; transcription by RNA polymerase III [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y535-1; Sequence=Displayed; Name=2; IsoId=Q9Y535-2; Sequence=VSP_007067; 


uniprotID: Q9H9Y2
geneSymbol: RPF1
name: Ribosome production factor 1 (Brix domain-containing protein 5) (Ribosome biogenesis protein RPF1)
length: 349
go: ENSG00000117133;
snps: rs2292191 rs7528067
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

opentargets:
nucleolus [GO:0005730]; preribosome, large subunit precursor [GO:0030687]; RNA binding [GO:0003723]; rRNA primary transcript binding [GO:0042134]; ribosomal large subunit assembly [GO:0000027]; rRNA processing [GO:0006364]


uniprotID: Q8N9B8
geneSymbol: RASGEF1A
reactome: R-HSA-5673001;
name: Ras-GEF domain-containing family member 1A
length: 481
go: ENSG00000198915;
sequence:

opentargets:
cytosol [GO:0005829]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; cell migration [GO:0016477]; MAPK cascade [GO:0000165]; positive regulation of Ras protein signal transduction [GO:0046579]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N9B8-1; Sequence=Displayed; Name=2; IsoId=Q8N9B8-2; Sequence=VSP_027312; 


uniprotID: Q8N431
geneSymbol: RASGEF1C
name: Ras-GEF domain-containing family member 1C
length: 466
sequence:

opentargets:
intracellular [GO:0005622]; guanyl-nucleotide exchange factor activity [GO:0005085]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8N431-1; Sequence=Displayed; Name=2; IsoId=Q8N431-2; Sequence=VSP_027316; 


uniprotID: Q8TEB9
geneSymbol: RHBDD1
pdb: 5EPP;
length: 315
go: ENSG00000144468;
snps: rs35731955
name:
Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; integral component of endoplasmic reticulum membrane [GO:0030176]; mitochondrion [GO:0005739]; endopeptidase activity [GO:0004175]; serine-type endopeptidase activity [GO:0004252]; apoptotic process [GO:0006915]; cellular response to unfolded protein [GO:0034620]; cellular response to UV [GO:0034644]; ERAD pathway [GO:0036503]; membrane protein intracellular domain proteolysis [GO:0031293]; membrane protein proteolysis [GO:0033619]; membrane protein proteolysis involved in retrograde protein transport, ER to cytosol [GO:1904211]; negative regulation of apoptotic process [GO:0043066]; positive regulation of protein catabolic process [GO:0045732]; positive regulation of protein processing [GO:0010954]; positive regulation of secretion [GO:0051047]; post-translational protein modification [GO:0043687]; spermatid differentiation [GO:0048515]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TEB9-1; Sequence=Displayed; Name=2; IsoId=Q8TEB9-2; Sequence=VSP_021203, VSP_021204; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion {ECO:0000305}.


uniprotID: Q3KRB8
geneSymbol: ARHGAP11B
reactome: R-HSA-194840;
name: Rho GTPase-activating protein 11B (Protein FAM7B1) (Rho-type GTPase-activating protein 11B)
length: 267
sequence:

opentargets:
cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; cerebral cortex development [GO:0021987]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]


uniprotID: Q6ZWK4
geneSymbol: RHEX
length: 172
go: ENSG00000263961;
name:
Regulator of hemoglobinization and erythroid cell expansion protein (Regulator of human erythroid cell expansion protein)

sequence:
MLTEVMEVWHGLVIAVVSLFLQACFLTAINYLLSRHMAHKSEQILKAASLQVPRPSPGHHHPPAVKEMKETQTERDIPMSDSLYRHDSDTPSDSLDSSCSSPPACQATEDVDYTQVVFSDPGELKNDSPLDYENIKEITDYVNVNPERHKPSFWYFVNPALSEPAEYDQVAM

opentargets:
integral component of membrane [GO:0016021]; plasma membrane [GO:0005886]; erythropoietin receptor binding [GO:0005128]; cellular response to erythropoietin [GO:0036018]; erythrocyte maturation [GO:0043249]; erythropoietin-mediated signaling pathway [GO:0038162]; positive regulation of erythrocyte differentiation [GO:0045648]

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25092874}; Single-pass membrane protein {ECO:0000255}.


uniprotID: Q6ZUM4
geneSymbol: ARHGAP27
reactome: R-HSA-194840;
pdb: 3PP2;
length: 889
go: ENSG00000159314;
snps: rs117139057
name:
Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTPase activator activity [GO:0005096]; SH3 domain binding [GO:0017124]; positive regulation of GTPase activity [GO:0043547]; receptor-mediated endocytosis [GO:0006898]; regulation of GTPase activity [GO:0043087]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZUM4-1; Sequence=Displayed; Name=2; IsoId=Q6ZUM4-2; Sequence=VSP_031053; Note=No experimental confirmation available.; Name=3; IsoId=Q6ZUM4-3; Sequence=VSP_031056; Note=No experimental confirmation available.; Name=4; Synonyms=SH3D20; IsoId=Q6ZUM4-4; Sequence=VSP_031054, VSP_031055; 


uniprotID: O75783
geneSymbol: RHBDL1
name: Rhomboid-related protein 1 (RRP) (EC 3.4.21.105) (Rhomboid-like protein 1)
length: 438
go: ENSG00000103269;
location: SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; serine-type endopeptidase activity [GO:0004252]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75783-1; Sequence=Displayed; Name=2; IsoId=O75783-2; Sequence=VSP_005372; 


uniprotID: Q52LW3
geneSymbol: ARHGAP29
reactome: R-HSA-194840;
length: 1261
go: ENSG00000137962;
snps: rs11165091 rs1999272
name:
Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; protein-containing complex [GO:0032991]; GTPase activator activity [GO:0005096]; metal ion binding [GO:0046872]; PDZ domain binding [GO:0030165]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q52LW3-1; Sequence=Displayed; Name=2; IsoId=Q52LW3-2; Sequence=VSP_031058, VSP_031059; Note=No experimental confirmation available.; 


uniprotID: Q7Z6I6
geneSymbol: ARHGAP30
reactome: R-HSA-194840;
name: Rho GTPase-activating protein 30 (Rho-type GTPase-activating protein 30)
length: 1101
go: ENSG00000186517;
snps: rs17854839 rs3813609
location: SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:21565175}.
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; GTPase activator activity [GO:0005096]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=L-ARHGAP30, L-30; IsoId=Q7Z6I6-1; Sequence=Displayed; Name=2; Synonyms=S-ARHGAP30, S-30; IsoId=Q7Z6I6-2; Sequence=VSP_023735; Note=No experimental confirmation available.; Name=3; IsoId=Q7Z6I6-3; Sequence=VSP_023732; Note=No experimental confirmation available.; Name=4; IsoId=Q7Z6I6-4; Sequence=VSP_023733, VSP_023734; Note=No experimental confirmation available.; 


uniprotID: Q8NHV9
geneSymbol: RHOXF1
length: 184
go: ENSG00000101883;
snps: rs2301977 rs138060880
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:11980563}.
name:
Rhox homeobox family member 1 (Ovary-, testis- and epididymis-expressed gene protein) (Paired-like homeobox protein PEPP-1)

sequence:
MARSLVHDTVFYCLSVYQVKISPTPQLGAASSAEGHVGQGAPGLMGNMNPEGGVNHENGMNRDGGMIPEGGGGNQEPRQQPQPPPEEPAQAAMEGPQPENMQPRTRRTKFTLLQVEELESVFRHTQYPDVPTRRELAENLGVTEDKVRVWFKNKRARCRRHQRELMLANELRADPDDCVYIVVD

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; sequence-specific DNA binding [GO:0043565]; gamete generation [GO:0007276]; intracellular steroid hormone receptor signaling pathway [GO:0030518]; multicellular organism development [GO:0007275]; positive regulation of gene expression [GO:0010628]; regulation of transcription, DNA-templated [GO:0006355]; sexual reproduction [GO:0019953]


uniprotID: P84095
geneSymbol: RHOG
reactome: R-HSA-114604;R-HSA-194840;R-HSA-416482;R-HSA-5625970;R-HSA-6798695;
name: Rho-related GTP-binding protein RhoG
length: 191
go: ENSG00000177105;
sequence:
MQSIKCVVVGDGAVGKTCLLICYTTNAFPKEYIPTVFDNYSAQSAVDGRTVNLNLWDTAGQEEYDRLRTLSYPQTNVFVICFSIASPPSYENVRHKWHPEVCHHCPDVPILLVGTKKDLRAQPDTLRRLKEQGQAPITPQQGQALAKQIHAVRYLECSALQQDGVKEVFAEAVRAVLNPTPIKRGRSCILL

opentargets:
cell cortex [GO:0005938]; cell projection [GO:0042995]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum membrane [GO:0005789]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; plasma membrane [GO:0005886]; secretory granule membrane [GO:0030667]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein kinase binding [GO:0019901]; actin cytoskeleton organization [GO:0030036]; actin filament organization [GO:0007015]; activation of GTPase activity [GO:0090630]; cell chemotaxis [GO:0060326]; establishment or maintenance of cell polarity [GO:0007163]; G protein-coupled receptor signaling pathway [GO:0007186]; neutrophil degranulation [GO:0043312]; positive regulation of cell proliferation [GO:0008284]; positive regulation of protein localization to plasma membrane [GO:1903078]; positive regulation of transcription, DNA-templated [GO:0045893]; Rac protein signal transduction [GO:0016601]; regulation of cell shape [GO:0008360]; regulation of ruffle assembly [GO:1900027]; regulation of small GTPase mediated signal transduction [GO:0051056]; Rho protein signal transduction [GO:0007266]


uniprotID: Q13278
geneSymbol: RIG
name: Putative protein RIG (Protein regulated in glioma)
length: 110
sequence:
MPFFSSCLCPSHYSGPSLPSSTSSSLPTGPENQLGFVLLQAMVHHANSSCVRNAFWLQITEKLTPALSIIISVVYLRCPEMVENRIGFLLNVKDSKTLSVVGPHPKPCIL


uniprotID: Q96LT9
geneSymbol: RNPC3
reactome: R-HSA-72165;
pdb: 3EGN;5OBN;
length: 517
go: ENSG00000185946;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14974681}.
name:
RNA-binding region-containing protein 3 (RNA-binding motif protein 40) (RNA-binding protein 40) (U11/U12 small nuclear ribonucleoprotein 65 kDa protein) (U11/U12 snRNP 65 kDa protein) (U11/U12-65K)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; U12-type spliceosomal complex [GO:0005689]; pre-mRNA intronic binding [GO:0097157]; U12 snRNA binding [GO:0030626]; mRNA splicing, via spliceosome [GO:0000398]; RNA splicing [GO:0008380]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96LT9-1; Sequence=Displayed; Name=2; IsoId=Q96LT9-2; Sequence=VSP_053413; Note=No experimental confirmation available.; 


uniprotID: Q9HAU8
geneSymbol: RNPEPL1
length: 725
go: ENSG00000142327;
name:
Aminopeptidase RNPEPL1 (EC 3.4.11.-) (Arginyl aminopeptidase-like 1) (Methionyl aminopeptidase) (EC 3.4.11.18)

sequence:

opentargets:
metalloaminopeptidase activity [GO:0070006]; zinc ion binding [GO:0008270]; proteolysis [GO:0006508]


uniprotID: Q5GAN3
geneSymbol: RNASE13
name: Probable inactive ribonuclease-like protein 13
length: 156
snps: rs2277847
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
MAPAVTRLLFLQLVLGPTLVMDIKMQIGSRNFYTLSIDYPRVNYPKGFRGYCNGLMSYMRGKMQNSDCPKIHYVIHAPWKAIQKFCKYSDSFCENYNEYCTLTQDSLPITVCSLSHQQPPTSCYYNSTLTNQKLYLLCSRKYEADPIGIAGLYSGI

opentargets:
extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; RNA phosphodiester bond hydrolysis [GO:0090501]


uniprotID: O00584
geneSymbol: RNASET2
reactome: R-HSA-6798695;
pdb: 3T0O;
name: Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6)
length: 256
go: ENSG00000026297;
snps: rs121918137 rs11159
sequence:

opentargets:
azurophil granule lumen [GO:0035578]; endoplasmic reticulum lumen [GO:0005788]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; lysosomal lumen [GO:0043202]; lysosome [GO:0005764]; endoribonuclease activity [GO:0004521]; ribonuclease activity [GO:0004540]; ribonuclease T2 activity [GO:0033897]; RNA binding [GO:0003723]; neutrophil degranulation [GO:0043312]; RNA catabolic process [GO:0006401]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O00584-1; Sequence=Displayed; Name=2; IsoId=O00584-2; Sequence=VSP_008405, VSP_008406; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; 

location:
SUBCELLULAR LOCATION: Secreted. Lysosome lumen. Endoplasmic reticulum lumen. Note=Subcellular fractionation of transfected ovarian cancer cells reveals full-length RNASET2 in the endoplasmic reticulum fraction and the 2 smaller RNASET2 proteolytic products in the lysosome fraction.


uniprotID: P51991
geneSymbol: HNRNPA3
reactome: R-HSA-72163;R-HSA-72203;
name: Heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3)
length: 378
go: ENSG00000170144;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes.
sequence:

opentargets:
catalytic step 2 spliceosome [GO:0071013]; cytoplasm [GO:0005737]; messenger ribonucleoprotein complex [GO:1990124]; neuron projection [GO:0043005]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; ribonucleoprotein granule [GO:0035770]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; RNA transmembrane transporter activity [GO:0051033]; mRNA splicing, via spliceosome [GO:0000398]; mRNA transport [GO:0051028]; RNA metabolic process [GO:0016070]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P51991-1; Sequence=Displayed; Name=2; IsoId=P51991-2; Sequence=VSP_011418; 


uniprotID: Q5GAN6
geneSymbol: RNASE10
name: Inactive ribonuclease-like protein 10
length: 216
go: ENSG00000182545;
snps: rs2067648
location: SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
sequence:

opentargets:
extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; heterotypic cell-cell adhesion [GO:0034113]; positive regulation of cell-cell adhesion [GO:0022409]; positive regulation of flagellated sperm motility [GO:1902093]; regulation of fertilization [GO:0080154]; RNA phosphodiester bond hydrolysis [GO:0090501]; single fertilization [GO:0007338]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5GAN6-1; Sequence=Displayed; Name=2; IsoId=Q5GAN6-2; Sequence=VSP_053579; 


uniprotID: P46778
geneSymbol: RPL21
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L21 (Large ribosomal subunit protein eL21)
length: 160
go: ENSG00000122026;
snps: rs17085349 rs587777527
sequence:
MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P49666}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:P49666, ECO:0000269|PubMed:25957688}.


uniprotID: Q6P5R6
geneSymbol: RPL22L1
name: 60S ribosomal protein L22-like 1 (Large ribosomal subunit protein eL22-like 1)
length: 122
go: ENSG00000163584;
snps: rs13462
sequence:
MAPQKDRKPKRSTWRFNLDLTHPVEDGIFDSGNFEQFLREKVKVNGKTGNLGNVVHIERFKNKITVVSEKQFSKRYLKYLTKKYLKKNNLRDWLRVVASDKETYELRYFQISQDEDESESED

opentargets:
cytosolic large ribosomal subunit [GO:0022625]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]


uniprotID: P19474
geneSymbol: TRIM21
reactome: R-HSA-1834941;R-HSA-3134975;R-HSA-877300;R-HSA-983168;
pdb: 2IWG;5JPX;5OLM;
length: 475
go: ENSG00000132109;
snps: rs1042302 rs58403334 rs2975162 rs2554934
name:
E3 ubiquitin-protein ligase TRIM21 (EC 2.3.2.27) (52 kDa Ro protein) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (RING finger protein 81) (RING-type E3 ubiquitin transferase TRIM21) (Ro(SS-A)) (Sjoegren syndrome type A antigen) (SS-A) (Tripartite motif-containing protein 21)

sequence:

opentargets:
autophagosome [GO:0005776]; cytoplasm [GO:0005737]; cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; ribonucleoprotein complex [GO:1990904]; DNA binding [GO:0003677]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; innate immune response [GO:0045087]; interferon-gamma-mediated signaling pathway [GO:0060333]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of protein deubiquitination [GO:0090086]; negative regulation of viral release from host cell [GO:1902187]; negative regulation of viral transcription [GO:0032897]; positive regulation of autophagy [GO:0010508]; positive regulation of cell cycle [GO:0045787]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of viral entry into host cell [GO:0046598]; protein autoubiquitination [GO:0051865]; protein destabilization [GO:0031648]; protein monoubiquitination [GO:0006513]; protein polyubiquitination [GO:0000209]; protein trimerization [GO:0070206]; protein ubiquitination [GO:0016567]; regulation of type I interferon production [GO:0032479]; response to interferon-gamma [GO:0034341]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=Ro52alpha, 52alpha; IsoId=P19474-1; Sequence=Displayed; Name=2; Synonyms=Ro52beta, 52beta; IsoId=P19474-2; Sequence=VSP_039627; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811, ECO:0000269|PubMed:26347139}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26347139}. Nucleus {ECO:0000269|PubMed:17156811}. Cytoplasm, P-body {ECO:0000269|PubMed:18361920}. Note=Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called processing bodies (P-bodies) that are located underneath the plasma membrane and also diffusely in the cytoplasm. They are located along the microtubules and are highly motile in cells. Colocalizes with DCP2 in P-bodies.


uniprotID: P22626
geneSymbol: HNRNPA2B1
reactome: R-HSA-72163;R-HSA-72203;R-HSA-8950505;
pdb: 1X4B;5EN1;5HO4;5WWE;5WWF;5WWG;
name: Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)
length: 353
go: ENSG00000122566;
snps: rs397515326
sequence:

opentargets:
Cajal body [GO:0015030]; catalytic step 2 spliceosome [GO:0071013]; chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; nuclear matrix [GO:0016363]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; G-rich strand telomeric DNA binding [GO:0098505]; identical protein binding [GO:0042802]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; mRNA binding [GO:0003729]; N6-methyladenosine-containing RNA binding [GO:1990247]; pre-mRNA intronic binding [GO:0097157]; RNA binding [GO:0003723]; single-stranded telomeric DNA binding [GO:0043047]; G-quadruplex DNA unwinding [GO:0044806]; interleukin-12-mediated signaling pathway [GO:0035722]; miRNA transport [GO:1990428]; mRNA export from nucleus [GO:0006406]; mRNA processing [GO:0006397]; mRNA splicing, via spliceosome [GO:0000398]; negative regulation of mRNA splicing, via spliceosome [GO:0048025]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of telomerase RNA reverse transcriptase activity [GO:1905663]; positive regulation of telomere maintenance via telomere lengthening [GO:1904358]; primary miRNA processing [GO:0031053]; RNA metabolic process [GO:0016070]; RNA transport [GO:0050658]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=B1; Synonyms=hnRNP B1; IsoId=P22626-1; Sequence=Displayed; Name=A2; Synonyms=hnRNP A2; IsoId=P22626-2; Sequence=VSP_005830; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:17289661}. Cytoplasmic granule {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:24356509}. Secreted, exosome {ECO:0000269|PubMed:24356509}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Component of ribonucleosomes (PubMed:17289661). Not found in the nucleolus (PubMed:17289661). Found in exosomes follwong sumoylation (PubMed:24356509). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:24356509}.; SUBCELLULAR LOCATION: Isoform A2: Nucleus {ECO:0000269|PubMed:10772824, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:24098712}. Cytoplasm {ECO:0000269|PubMed:10772824, ECO:0000269|PubMed:17289661}. Note=Predominantly nucleoplasmic, however is also found in the cytoplasm of cells in some tissues (PubMed:17289661). {ECO:0000269|PubMed:17289661}.


uniprotID: Q99729
geneSymbol: HNRNPAB
pdb: 3S7R;
name: Heterogeneous nuclear ribonucleoprotein A/B (hnRNP A/B) (APOBEC1-binding protein 1) (ABBP-1)
length: 332
go: ENSG00000197451;
sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; RNA polymerase II transcription factor complex [GO:0090575]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; sequence-specific double-stranded DNA binding [GO:1990837]; epithelial to mesenchymal transition [GO:0001837]; positive regulation of transcription, DNA-templated [GO:0045893]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q99729-1; Sequence=Displayed; Name=2; IsoId=Q99729-2; Sequence=VSP_007826, VSP_007828; Name=3; IsoId=Q99729-3; Sequence=VSP_007826, VSP_007828, VSP_007829; Name=4; IsoId=Q99729-4; Sequence=VSP_007826, VSP_007829; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.


uniprotID: O75116
geneSymbol: ROCK2
reactome: R-HSA-3928662;R-HSA-3928663;R-HSA-416482;R-HSA-416572;R-HSA-4420097;R-HSA-5627117;
pdb: 4L6Q;4WOT;5U7Q;5U7R;
length: 1388
go: ENSG00000134318;
drug: DB08756;
snps: rs2230774 rs35768389 rs34945852
name:
Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2)

sequence:

opentargets:
centrosome [GO:0005813]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein serine/threonine kinase activity [GO:0004674]; Rho GTPase binding [GO:0017048]; Rho-dependent protein serine/threonine kinase activity [GO:0072518]; RNA binding [GO:0003723]; structural molecule activity [GO:0005198]; aortic valve morphogenesis [GO:0003180]; cellular response to testosterone stimulus [GO:0071394]; centrosome duplication [GO:0051298]; cortical actin cytoskeleton organization [GO:0030866]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled receptor signaling pathway [GO:0007186]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of protein localization to lysosome [GO:0150033]; peptidyl-serine phosphorylation [GO:0018105]; peptidyl-threonine phosphorylation [GO:0018107]; positive regulation of amyloid precursor protein catabolic process [GO:1902993]; positive regulation of amyloid-beta formation [GO:1902004]; positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process [GO:1902961]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of cell migration [GO:0030335]; positive regulation of centrosome duplication [GO:0010825]; positive regulation of connective tissue growth factor production [GO:0032723]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of fibroblast growth factor production [GO:0090271]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; positive regulation of protein localization to early endosome [GO:1902966]; positive regulation of protein phosphorylation [GO:0001934]; positive regulation of stress fiber assembly [GO:0051496]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of cell adhesion [GO:0030155]; regulation of cell motility [GO:2000145]; regulation of circadian rhythm [GO:0042752]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of protein metabolic process [GO:0051246]; regulation of stress fiber assembly [GO:0051492]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; rhythmic process [GO:0048511]; smooth muscle contraction [GO:0006939]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]; viral RNA genome replication [GO:0039694]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}.


uniprotID: Q9GZN7
geneSymbol: ROGDI
pdb: 5XQH;5XQI;
name: Protein rogdi homolog
length: 287
go: ENSG00000067836;
snps: rs2305659
sequence:

opentargets:
axon [GO:0030424]; cell junction [GO:0030054]; dendrite [GO:0030425]; intracellular [GO:0005622]; nuclear envelope [GO:0005635]; perikaryon [GO:0043204]; presynaptic membrane [GO:0042734]; synaptic vesicle [GO:0008021]; brain development [GO:0007420]; hemopoiesis [GO:0030097]; neurogenesis [GO:0022008]; odontogenesis of dentin-containing tooth [GO:0042475]; positive regulation of cell proliferation [GO:0008284]

location:
SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:22482807}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:Q4V7D2}. Cell projection, axon {ECO:0000250|UniProtKB:Q4V7D2}. Perikaryon {ECO:0000250|UniProtKB:Q4V7D2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q4V7D2}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q4V7D2}. Note=Detected primarily at presynaptic sites on axons, and to a lesser degree in soma and dendrites. Not detected at post-synaptic sites. {ECO:0000250|UniProtKB:Q4V7D2}.


uniprotID: Q96C74
geneSymbol: ROPN1L
name: Ropporin-1-like protein (ROPN1-like protein) (AKAP-associated sperm protein)
length: 230
go: ENSG00000145491;
snps: rs35573613 rs2303986 rs17851209
sequence:

opentargets:
cilium [GO:0005929]; cytoplasm [GO:0005737]; motile cilium [GO:0031514]; epithelial cilium movement [GO:0003351]; flagellated sperm motility [GO:0030317]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240]

location:
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9EQ00}. Cell projection, cilium {ECO:0000269|PubMed:27120127}.


uniprotID: P08922
geneSymbol: ROS1
pdb: 3ZBF;4UXL;
length: 2347
go: ENSG00000047936;
name:
Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1) (Proto-oncogene c-Ros) (Proto-oncogene c-Ros-1) (Receptor tyrosine kinase c-ros oncogene 1) (c-Ros receptor tyrosine kinase)

sequence:

opentargets:
cell surface [GO:0009986]; cytoplasm [GO:0005737]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; perinuclear region of cytoplasm [GO:0048471]; receptor complex [GO:0043235]; ATP binding [GO:0005524]; protein phosphatase binding [GO:0019903]; protein tyrosine kinase activity [GO:0004713]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]; transmembrane signaling receptor activity [GO:0004888]; cell differentiation [GO:0030154]; cell proliferation [GO:0008283]; columnar/cuboidal epithelial cell development [GO:0002066]; negative regulation of apoptotic process [GO:0043066]; negative regulation of gene expression [GO:0010629]; negative regulation of signal transduction [GO:0009968]; peptidyl-tyrosine autophosphorylation [GO:0038083]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; protein phosphorylation [GO:0006468]; regulation of cell growth [GO:0001558]; regulation of ERK1 and ERK2 cascade [GO:0070372]; regulation of phosphate transport [GO:0010966]; regulation of TOR signaling [GO:0032006]; signal transduction by protein phosphorylation [GO:0023014]; spermatogenesis [GO:0007283]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

snps:
rs45606237 rs34245787 rs1998206 rs2243380 rs55959124 rs55707658 rs56274823 rs1444274116 rs28639589 rs34203286 rs34582164 rs2229079 rs56192249 rs35269727 rs36106063 rs17079086 rs35841892 rs12664076 rs9489124 rs45569132 rs3752566 rs556427413 rs75510639 rs529038 rs529156 rs619203 rs210968 rs35932630 


uniprotID: Q9H6T3
geneSymbol: RPAP3
pdb: 4CGV;4CGW;6EZ4;6FD7;6FDP;6FDT;6FO1;6GXZ;
name: RNA polymerase II-associated protein 3
length: 665
go: ENSG00000005175;
opentargets: cytosol [GO:0005829]; R2TP complex [GO:0097255]
snps: rs11168196
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H6T3-1; Sequence=Displayed; Name=2; IsoId=Q9H6T3-2; Sequence=VSP_027957; Note=No experimental confirmation available.; Name=3; IsoId=Q9H6T3-3; Sequence=VSP_044882; Note=No experimental confirmation available.; 


uniprotID: Q9H1A7
geneSymbol: POLR2J3
length: 115
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
DNA-directed RNA polymerase II subunit RPB11-b2 (RNA polymerase II subunit B11-b2) (RPB11b2) (DNA-directed RNA polymerase II subunit J3)

sequence:
MNAPPAFESFLLFEGEKITINKDTKVPNACLFTMNKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRTCLLPLRLLP

opentargets:
RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]


uniprotID: P24928
geneSymbol: POLR2A
length: 1970
go: ENSG00000181222;
snps: rs2229198
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-168325;R-HSA-203927;R-HSA-452723;R-HSA-5578749;R-HSA-5601884;R-HSA-5617472;R-HSA-674695;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6796648;R-HSA-6803529;R-HSA-6807505;R-HSA-72086;R-HSA-72163;R-HSA-72165;R-HSA-72203;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-75955;R-HSA-76042;R-HSA-77075;R-HSA-8851708;R-HSA-9018519;

pdb:
2GHQ;2GHT;2LTO;3D9K;3D9L;3D9M;3D9N;3D9O;3D9P;4JXT;5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;5M3H;5M3J;

name:
DNA-directed RNA polymerase II subunit RPB1 (RNA polymerase II subunit B1) (EC 2.7.7.6) (DNA-directed RNA polymerase II subunit A) (DNA-directed RNA polymerase III largest subunit) (RNA-directed RNA polymerase II subunit RPB1) (EC 2.7.7.48)

sequence:

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; promoter-specific chromatin binding [GO:1990841]; protein C-terminus binding [GO:0008022]; RNA binding [GO:0003723]; RNA-directed 5'-3' RNA polymerase activity [GO:0003968]; ubiquitin protein ligase binding [GO:0031625]; 7-methylguanosine mRNA capping [GO:0006370]; DNA-templated transcription, termination [GO:0006353]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of RNA splicing [GO:0033120]; regulation of gene silencing by miRNA [GO:0060964]; regulation of transcription, DNA-templated [GO:0006355]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P24928-1; Sequence=Displayed; Name=2; IsoId=P24928-2; Sequence=VSP_056184, VSP_056185; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26566685, ECO:0000269|PubMed:9852112}. Cytoplasm {ECO:0000269|PubMed:26566685}. Note=Hypophosphorylated form is mainly found in the cytoplasm, while the hyperphosphorylated and active form is nuclear. {ECO:0000269|PubMed:26566685}.


uniprotID: P61353
geneSymbol: RPL27
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L27 (Large ribosomal subunit protein eL27)
length: 136
go: ENSG00000131469;
sequence:
MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF

opentargets:
cytoplasmic side of rough endoplasmic reticulum membrane [GO:0098556]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:A1XQU5}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:A1XQU5, ECO:0000269|PubMed:25957688}.


uniprotID: P30876
geneSymbol: POLR2B
pdb: 5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 1174
go: ENSG00000047315;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-168325;R-HSA-203927;R-HSA-452723;R-HSA-5578749;R-HSA-5601884;R-HSA-5617472;R-HSA-674695;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6796648;R-HSA-6803529;R-HSA-6807505;R-HSA-72086;R-HSA-72163;R-HSA-72165;R-HSA-72203;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-75955;R-HSA-76042;R-HSA-77075;R-HSA-8851708;R-HSA-9018519;

name:
DNA-directed RNA polymerase II subunit RPB2 (EC 2.7.7.6) (DNA-directed RNA polymerase II 140 kDa polypeptide) (DNA-directed RNA polymerase II subunit B) (RNA polymerase II subunit 2) (RNA polymerase II subunit B2)

sequence:

opentargets:
membrane [GO:0016020]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; RNA binding [GO:0003723]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: P19387
geneSymbol: POLR2C
pdb: 5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 275
go: ENSG00000102978;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
reactome:
R-HSA-112382;R-HSA-113418;R-HSA-167152;R-HSA-167158;R-HSA-167160;R-HSA-167161;R-HSA-167162;R-HSA-167172;R-HSA-167200;R-HSA-167238;R-HSA-167242;R-HSA-167243;R-HSA-167246;R-HSA-167287;R-HSA-167290;R-HSA-168325;R-HSA-203927;R-HSA-452723;R-HSA-5578749;R-HSA-5601884;R-HSA-5617472;R-HSA-674695;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6796648;R-HSA-6803529;R-HSA-6807505;R-HSA-72086;R-HSA-72163;R-HSA-72165;R-HSA-72203;R-HSA-73776;R-HSA-73779;R-HSA-75953;R-HSA-75955;R-HSA-76042;R-HSA-77075;R-HSA-8851708;R-HSA-9018519;

name:
DNA-directed RNA polymerase II subunit RPB3 (RNA polymerase II subunit 3) (RNA polymerase II subunit B3) (DNA-directed RNA polymerase II 33 kDa polypeptide) (RPB33) (DNA-directed RNA polymerase II subunit C) (RPB31)

sequence:

opentargets:
cytosol [GO:0005829]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: O15514
geneSymbol: POLR2D
pdb: 2C35;5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 142
go: ENSG00000144231;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
name:
DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16)

sequence:
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RNA polymerase II, core complex [GO:0005665]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleotide binding [GO:0000166]; translation initiation factor binding [GO:0031369]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA export from nucleus in response to heat stress [GO:0031990]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of translational initiation [GO:0045948]; recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex [GO:0034402]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: P62487
geneSymbol: POLR2G
pdb: 2C35;5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 172
go: ENSG00000168002;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
name:
DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19)

sequence:
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; P-body [GO:0000932]; RNA polymerase II, core complex [GO:0005665]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]; single-stranded RNA binding [GO:0003727]; translation initiation factor binding [GO:0031369]; 7-methylguanosine mRNA capping [GO:0006370]; apoptotic process [GO:0006915]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; nuclear-transcribed mRNA catabolic process, exonucleolytic [GO:0000291]; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060213]; positive regulation of translational initiation [GO:0045948]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: Q9NW08
geneSymbol: POLR3B
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 1133
go: ENSG00000013503;
snps: rs267608683 rs138249161 rs17038460 rs267608687 rs267608689
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
DNA-directed RNA polymerase III subunit RPC2 (RNA polymerase III subunit C2) (EC 2.7.7.6) (C128) (DNA-directed RNA polymerase III 127.6 kDa polypeptide) (DNA-directed RNA polymerase III subunit B)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9NW08-1; Sequence=Displayed; Name=2; IsoId=Q9NW08-2; Sequence=VSP_045286; Note=No experimental confirmation available.; 


uniprotID: Q9BUI4
geneSymbol: POLR3C
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
pdb: 2XUB;2XV4;5AFQ;
length: 534
go: ENSG00000186141;
snps: rs1044697
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
DNA-directed RNA polymerase III subunit RPC3 (RNA polymerase III subunit C3) (DNA-directed RNA polymerase III subunit C) (RNA polymerase III 62 kDa subunit) (RPC62)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]


uniprotID: Q9H9Y6
geneSymbol: POLR1B
reactome: R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 1135
go: ENSG00000125630;
snps: rs1545133
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11250903}.
name:
DNA-directed RNA polymerase I subunit RPA2 (RNA polymerase I subunit 2) (EC 2.7.7.6) (DNA-directed RNA polymerase I 135 kDa polypeptide) (RPA135)

sequence:

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase I complex [GO:0005736]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; ribonucleoside binding [GO:0032549]; embryo implantation [GO:0007566]; nucleologenesis [GO:0017126]; positive regulation of gene expression, epigenetic [GO:0045815]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation from RNA polymerase I promoter [GO:0006361]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9H9Y6-1; Sequence=Displayed; Name=2; IsoId=Q9H9Y6-2; Sequence=VSP_017823; Name=3; IsoId=Q9H9Y6-3; Sequence=VSP_056750; Name=4; IsoId=Q9H9Y6-4; Sequence=VSP_056749; Name=5; IsoId=Q9H9Y6-5; Sequence=VSP_056751; 


uniprotID: O15446
geneSymbol: CD3EAP
reactome: R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 510
go: ENSG00000117877;
snps: rs735482 rs3212989 rs762562 rs2336219 rs3212986 rs3212986
name:
DNA-directed RNA polymerase I subunit RPA34 (A34.5) (Antisense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CAST) (CD3E-associated protein) (RNA polymerase I-associated factor PAF49)

sequence:

opentargets:
chromosome [GO:0005694]; cytosol [GO:0005829]; fibrillar center [GO:0001650]; mitochondrion [GO:0005739]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I transcription factor complex [GO:0000120]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; RNA binding [GO:0003723]; positive regulation of gene expression, epigenetic [GO:0045815]; rRNA transcription [GO:0009303]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15446-1; Sequence=Displayed; Name=2; Synonyms=CAST; IsoId=O15446-2; Sequence=VSP_017673; Note=No experimental confirmation available. Has sharply different functional characteristics.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9426281}. Chromosome {ECO:0000269|PubMed:9426281}. Note=Found at the fibrillar centers of the nucleolus in interphase and during cell division it is localized to the nucleolus organizer regions of the chromosomes.


uniprotID: Q9GZS1
geneSymbol: POLR1E
reactome: R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73863;
length: 419
go: ENSG00000137054;
snps: rs7863488 rs7867180 rs10814571
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
name:
DNA-directed RNA polymerase I subunit RPA49 (RNA polymerase I subunit A49) (DNA-directed RNA polymerase I subunit E) (RNA polymerase I-associated factor 1) (RNA polymerase I-associated factor 53)

sequence:

opentargets:
fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; RNA polymerase I transcription factor binding [GO:0001179]; positive regulation of gene expression, epigenetic [GO:0045815]; RNA polymerase I preinitiation complex assembly [GO:0001188]; termination of RNA polymerase I transcription [GO:0006363]; transcription initiation from RNA polymerase I promoter [GO:0006361]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=Q9GZS1-2; Sequence=Displayed; Name=1; IsoId=Q9GZS1-1; Sequence=VSP_059915; Note=Dubious isoform produced through intron retention. No experimental confirmation available. {ECO:0000305}; 


uniprotID: P61218
geneSymbol: POLR2F
pdb: 1QKL;5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 127
go: ENSG00000100142;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
name:
DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15)

sequence:
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIITD

opentargets:
cytosol [GO:0005829]; fibrillar center [GO:0001650]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: P52434
geneSymbol: POLR2H
pdb: 2F3I;5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 150
go: ENSG00000163882;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9852112, ECO:0000269|Ref.6}.
name:
DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)

sequence:
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-DNA complex [GO:0032993]; RNA polymerase I complex [GO:0005736]; RNA polymerase II, core complex [GO:0005665]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; single-stranded DNA binding [GO:0003697]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; positive regulation of gene expression, epigenetic [GO:0045815]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase II [GO:0006366]; transcription by RNA polymerase III [GO:0006383]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase I promoter [GO:0006361]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P52434-1; Sequence=Displayed; Name=2; IsoId=P52434-2; Sequence=VSP_055018; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=3; IsoId=P52434-3; Sequence=VSP_055017; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=4; IsoId=P52434-4; Sequence=VSP_055019; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=5; IsoId=P52434-5; Sequence=VSP_055017, VSP_055018; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q9UNX3
geneSymbol: RPL26L1
name: 60S ribosomal protein L26-like 1 (Large ribosomal subunit protein uL24-like 1)
length: 145
go: ENSG00000037241;
drug: DB02494;DB07374;DB08437;
sequence:
MKFNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIRKDDEVQVVRGHYKGQQIGKVVQVYRKKYVIYIERVQREKANGTTVHVGIHPSKVVITRLKLDKDRKKILERKAKSRQVGKEKGKYKEELIEKMQE

opentargets:
cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal large subunit biogenesis [GO:0042273]


uniprotID: O15160
geneSymbol: POLR1C
length: 346
go: ENSG00000171453;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26151409}.
reactome:
R-HSA-1834949;R-HSA-427413;R-HSA-5250924;R-HSA-73762;R-HSA-73772;R-HSA-73777;R-HSA-73780;R-HSA-73863;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;

name:
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase I complex [GO:0005736]; RNA polymerase III complex [GO:0005666]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; protein dimerization activity [GO:0046983]; positive regulation of gene expression, epigenetic [GO:0045815]; termination of RNA polymerase I transcription [GO:0006363]; transcription by RNA polymerase I [GO:0006360]; transcription by RNA polymerase III [GO:0006383]; transcription initiation from RNA polymerase I promoter [GO:0006361]

snps:
rs796052126 rs796052124 rs141471029 rs371802902 rs796052127 rs201320592 rs796052125 rs373046018 rs751006626 rs191582628 rs141156009 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O15160-1; Sequence=Displayed; Name=2; IsoId=O15160-2; Sequence=VSP_005913; Note=No experimental confirmation available.; 


uniprotID: P46776
geneSymbol: RPL27A
pdb: 4BXF;4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L27a (Large ribosomal subunit protein uL15)
length: 148
go: ENSG00000166441;
sequence:
MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGLHHHRINFDKYHPGYFGKVGMKHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKTGAAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKSVGGACVLVA

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P52435
geneSymbol: POLR2J
pdb: 5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 117
go: ENSG00000005075;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
name:
DNA-directed RNA polymerase II subunit RPB11-a (RNA polymerase II subunit B11-a) (RPB11a) (DNA-directed RNA polymerase II subunit J-1) (RNA polymerase II 13.3 kDa subunit)

sequence:
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; LRR domain binding [GO:0030275]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; mRNA splicing, via spliceosome [GO:0000398]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: Q9GZM3
geneSymbol: POLR2J2
length: 115
snps: rs62483491
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
DNA-directed RNA polymerase II subunit RPB11-b1 (RNA polymerase II subunit B11-b1) (RPB11b1) (DNA-directed RNA polymerase II subunit J2)

sequence:
MNAPPAFESFLLFEGEKITINKDTKVPKACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRTCLLPLRLLP

opentargets:
RNA polymerase II, core complex [GO:0005665]; DNA binding [GO:0003677]; protein dimerization activity [GO:0046983]; RNA polymerase II activity [GO:0001055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=RPB11b1-alpha; IsoId=Q9GZM3-1; Sequence=Displayed; Name=2; Synonyms=RPB11b1-beta; IsoId=Q9GZM3-2; Sequence=VSP_030820; 


uniprotID: P36954
geneSymbol: POLR2I
pdb: 5IY6;5IY7;5IY8;5IY9;5IYA;5IYB;5IYC;5IYD;
length: 125
go: ENSG00000105258;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:9852112}.
name:
DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5)

sequence:
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; 7-methylguanosine mRNA capping [GO:0006370]; fibroblast growth factor receptor signaling pathway [GO:0008543]; maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter [GO:0001193]; mRNA cleavage [GO:0006379]; mRNA splicing, via spliceosome [GO:0000398]; regulation of gene silencing by miRNA [GO:0060964]; RNA metabolic process [GO:0016070]; snRNA transcription by RNA polymerase II [GO:0042795]; transcription by RNA polymerase II [GO:0006366]; transcription elongation from RNA polymerase II promoter [GO:0006368]; transcription initiation from RNA polymerase II promoter [GO:0006367]; transcription-coupled nucleotide-excision repair [GO:0006283]


uniprotID: Q9Y2Y1
geneSymbol: POLR3K
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 108
snps: rs183360
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:P32529}.
name:
DNA-directed RNA polymerase III subunit RPC10 (RNA polymerase III subunit C10) (DNA-directed RNA polymerase III subunit K) (RNA polymerase III 12.5 kDa subunit) (RPC12.5) (RNA polymerase III subunit C11) (HsC11p) (RPC11) (hRPC11)

sequence:
MLLFCPGCGNGLIVEEGQRCHRFSCNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAESCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD

opentargets:
cytosol [GO:0005829]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleic acid binding [GO:0003676]; zinc ion binding [GO:0008270]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; termination of RNA polymerase III transcription [GO:0006386]; transcription by RNA polymerase III [GO:0006383]; tRNA 3'-trailer cleavage [GO:0042779]


uniprotID: O14802
geneSymbol: POLR3A
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 1390
go: ENSG00000148606;
location: SUBCELLULAR LOCATION: Nucleus.
name:
DNA-directed RNA polymerase III subunit RPC1 (RNA polymerase III subunit C1) (EC 2.7.7.6) (DNA-directed RNA polymerase III largest subunit) (DNA-directed RNA polymerase III subunit A) (RNA polymerase III 155 kDa subunit) (RPC155) (RNA polymerase III subunit C160)

sequence:

opentargets:
cytosol [GO:0005829]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; metal ion binding [GO:0046872]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]; transcription, DNA-templated [GO:0006351]

snps:
rs1375717376 rs1217230904 rs267608673 rs267608668 rs34588967 rs762708292 rs267608676 rs267608670 rs35354908 rs267608679 rs267608672 rs267608671 rs267608681 rs267608682 rs371703979 


uniprotID: P0DPB5
geneSymbol: POLR1D
name: Protein POLR1D, isoform 2
length: 122
go: ENSG00000186184;
sequence:
MEEDQELERKAIEELLKEAKRGKTRAETMGPMGWMKCPLASTNKRFLINTIKNTLPSHKEQDHEQKEGDKEPAKSQAQKEENPKKHRSHPYKHSFRARGSASYSPPRKRSSQDKYEKRSNRR

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=2; IsoId=P0DPB5-1; Sequence=Displayed; Name=1; IsoId=P0DPB6-1, Q9Y2S0-1; Sequence=External; 


uniprotID: Q9H1D9
geneSymbol: POLR3F
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
pdb: 2DK5;2YU3;
length: 316
go: ENSG00000132664;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
name:
DNA-directed RNA polymerase III subunit RPC6 (RNA polymerase III subunit C6) (DNA-directed RNA polymerase III subunit F) (RNA polymerase III 39 kDa subunit) (RPC39)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; double-stranded DNA binding [GO:0003690]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]


uniprotID: Q9BT43
geneSymbol: POLR3GL
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
pdb: 5AFQ;
length: 218
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154270}.
name:
DNA-directed RNA polymerase III subunit RPC7-like (RNA polymerase III subunit C7-like) (DNA-directed RNA polymerase III subunit G-like) (RNA polymerase III 32 kDa beta subunit) (RPC32-beta)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; transcription by RNA polymerase III [GO:0006383]


uniprotID: O15318
geneSymbol: POLR3G
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 223
go: ENSG00000113356;
name:
DNA-directed RNA polymerase III subunit RPC7 (RNA polymerase III subunit C7) (DNA-directed RNA polymerase III subunit G) (RNA polymerase III 32 kDa apha subunit) (RPC32-alpha) (RNA polymerase III 32 kDa subunit) (RPC32)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; cell proliferation [GO:0008283]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; regulation of transcription by RNA polymerase III [GO:0006359]; transcription by RNA polymerase III [GO:0006383]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154270, ECO:0000269|PubMed:21898682}. Cytoplasm {ECO:0000250|UniProtKB:Q6NXY9}. Note=Excluded from nucleoli (PubMed:21898682). In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts (By similarity). {ECO:0000250|UniProtKB:Q6NXY9, ECO:0000269|PubMed:21898682}.


uniprotID: O75575
geneSymbol: CRCP
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 148
go: ENSG00000241258;
name:
DNA-directed RNA polymerase III subunit RPC9 (RNA polymerase III subunit C9) (Calcitonin gene-related peptide-receptor component protein) (CGRP-RCP) (CGRP-receptor component protein) (CGRPRCP) (HsC17)

sequence:
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA

opentargets:
acrosomal vesicle [GO:0001669]; cytosol [GO:0005829]; DNA polymerase III complex [GO:0009360]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; RNA polymerase III complex [GO:0005666]; calcitonin gene-related peptide receptor activity [GO:0001635]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; nucleotide binding [GO:0000166]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; neuropeptide signaling pathway [GO:0007218]; transcription by RNA polymerase III [GO:0006383]; transcription initiation from RNA polymerase III promoter [GO:0006384]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O75575-1; Sequence=Displayed; Name=2; IsoId=O75575-2; Sequence=VSP_007538; Name=3; IsoId=O75575-3; Sequence=VSP_043249, VSP_007538; Note=No experimental confirmation available.; Name=4; IsoId=O75575-4; Sequence=VSP_046273; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.


uniprotID: Q16518
geneSymbol: RPE65
reactome: R-HSA-2453902;
length: 533
go: ENSG00000116745;
name:
Retinoid isomerohydrolase (EC 3.1.1.64) (All-trans-retinyl-palmitate hydrolase) (Meso-zeaxanthin isomerase) (EC 5.3.3.-) (Retinal pigment epithelium-specific 65 kDa protein) (Retinol isomerase)

sequence:

opentargets:
cell body [GO:0044297]; endoplasmic reticulum [GO:0005783]; membrane [GO:0016020]; organelle membrane [GO:0031090]; plasma membrane [GO:0005886]; all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity [GO:0052885]; all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity [GO:0052884]; cardiolipin binding [GO:1901612]; isomerase activity [GO:0016853]; metal ion binding [GO:0046872]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [GO:0016702]; phosphatidylcholine binding [GO:0031210]; phosphatidylserine binding [GO:0001786]; retinal isomerase activity [GO:0004744]; cellular response to electrical stimulus [GO:0071257]; circadian rhythm [GO:0007623]; detection of light stimulus involved in visual perception [GO:0050908]; insulin receptor signaling pathway [GO:0008286]; neural retina development [GO:0003407]; regulation of rhodopsin gene expression [GO:0007468]; retina homeostasis [GO:0001895]; retina morphogenesis in camera-type eye [GO:0060042]; retinal metabolic process [GO:0042574]; retinoid metabolic process [GO:0001523]; visual perception [GO:0007601]; vitamin A metabolic process [GO:0006776]; zeaxanthin biosynthetic process [GO:1901827]

snps:
rs61751277 rs61751281 rs61751282 rs61752866 rs61752869 rs61752870 rs61752873 rs61752873 rs61752871 rs61752874 rs143056561 rs62642584 rs61752878 rs61752880 rs61752882 rs61752883 rs61752884 rs61752884 rs61752896 rs281865289 rs61752901 rs149916178 rs61752908 rs61752909 rs121917744 rs62653012 rs62653011 rs62635773 rs62636299 rs62636300 rs34627040 rs62636302 rs62637002 rs62637004 rs62637007 rs121917745 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A9C3R9}. Cell membrane {ECO:0000269|PubMed:19049981}; Lipid-anchor {ECO:0000269|PubMed:19049981}. Microsome membrane {ECO:0000250|UniProtKB:Q28175}. Note=Attached to the membrane by a lipid anchor when palmitoylated (membrane form), soluble when unpalmitoylated. Undergoes light-dependent intracellular transport to become more concentrated in the central region of the retina pigment epithelium cells. {ECO:0000269|PubMed:19049981, ECO:0000269|PubMed:21493626}.


uniprotID: Q96AT9
geneSymbol: RPE
reactome: R-HSA-71336;
pdb: 3OVP;3OVQ;3OVR;3QC3;
name: Ribulose-phosphate 3-epimerase (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase)
length: 228
go: ENSG00000197713;
sequence:

opentargets:
cytosol [GO:0005829]; extracellular exosome [GO:0070062]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; protein homodimerization activity [GO:0042803]; ribulose-phosphate 3-epimerase activity [GO:0004750]; carbohydrate metabolic process [GO:0005975]; cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q96AT9-1; Sequence=Displayed; Name=2; IsoId=Q96AT9-2; Sequence=VSP_008317, VSP_008318; Note=No experimental confirmation available.; Name=3; IsoId=Q96AT9-3; Sequence=VSP_047117, VSP_008318; Note=Gene prediction based on EST data.; Name=4; IsoId=Q96AT9-4; Sequence=VSP_055265; Note=No experimental confirmation available.; Name=5; IsoId=Q96AT9-5; Sequence=VSP_047117; Note=Gene prediction based on EST data.; 


uniprotID: Q9Y4G8
geneSymbol: RAPGEF2
reactome: R-HSA-5673001;
length: 1499
go: ENSG00000109756;
name:
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; bicellular tight junction [GO:0005923]; cell-cell junction [GO:0005911]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; integral component of plasma membrane [GO:0005887]; late endosome [GO:0005770]; membrane [GO:0016020]; neuron projection [GO:0043005]; neuronal cell body [GO:0043025]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; synapse [GO:0045202]; beta-1 adrenergic receptor binding [GO:0031697]; calcium ion binding [GO:0005509]; cAMP binding [GO:0030552]; diacylglycerol binding [GO:0019992]; GTPase activator activity [GO:0005096]; PDZ domain binding [GO:0030165]; phosphatidic acid binding [GO:0070300]; Rap guanyl-nucleotide exchange factor activity [GO:0017034]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; WW domain binding [GO:0050699]; adenylate cyclase-activating adrenergic receptor signaling pathway [GO:0071880]; blood vessel development [GO:0001568]; brain-derived neurotrophic factor receptor signaling pathway [GO:0031547]; cAMP-mediated signaling [GO:0019933]; cellular response to cAMP [GO:0071320]; cellular response to cGMP [GO:0071321]; cellular response to nerve growth factor stimulus [GO:1990090]; establishment of endothelial barrier [GO:0061028]; establishment of endothelial intestinal barrier [GO:0090557]; forebrain neuron development [GO:0021884]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; negative regulation of cell proliferation [GO:0008285]; negative regulation of dendrite morphogenesis [GO:0050774]; negative regulation of melanin biosynthetic process [GO:0048022]; nerve growth factor signaling pathway [GO:0038180]; neuron migration [GO:0001764]; neuron projection development [GO:0031175]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cAMP-dependent protein kinase activity [GO:2000481]; positive regulation of cAMP-mediated signaling [GO:0043950]; positive regulation of dendritic cell apoptotic process [GO:2000670]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron migration [GO:2001224]; positive regulation of neuron projection development [GO:0010976]; positive regulation of protein binding [GO:0032092]; positive regulation of protein kinase activity [GO:0045860]; positive regulation of vasculogenesis [GO:2001214]; protein localization to plasma membrane [GO:0072659]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of synaptic plasticity [GO:0048167]; small GTPase mediated signal transduction [GO:0007264]; ventricular system development [GO:0021591]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell membrane. Late endosome. Cell junction {ECO:0000250}. Note=Associated with the synaptic plasma membrane. Colocalizes with ADRB1 at the plasma membrane. Synaptosome. Enriched in synaptic plasma membrane and neuronal cell body. Colocalized with CTNNB1 at cell-cell contacts (By similarity). Localized diffusely in the cytoplasm before neuronal growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with the high affinity nerve growth factor receptor NTRK1 at late endosomes. Translocated to the perinuclear region in a RAP1A-dependent manner. Translocated to the cell membrane. {ECO:0000250}.


uniprotID: O95398
geneSymbol: RAPGEF3
reactome: R-HSA-354192;R-HSA-381676;R-HSA-392517;R-HSA-422356;
length: 923
go: ENSG00000079337;
snps: rs11168230 rs2016123 rs12422983 rs61709815
location: SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:10777494}.
name:
Rap guanine nucleotide exchange factor 3 (Exchange factor directly activated by cAMP 1) (Exchange protein directly activated by cAMP 1) (EPAC 1) (Rap1 guanine-nucleotide-exchange factor directly activated by cAMP) (cAMP-regulated guanine nucleotide exchange factor I) (cAMP-GEFI)

sequence:

opentargets:
endomembrane system [GO:0012505]; extracellular exosome [GO:0070062]; filopodium [GO:0030175]; intracellular [GO:0005622]; lamellipodium [GO:0030027]; membrane [GO:0016020]; microvillus [GO:0005902]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; protein domain specific binding [GO:0019904]; Rap guanyl-nucleotide exchange factor activity [GO:0017034]; angiogenesis [GO:0001525]; cAMP-mediated signaling [GO:0019933]; cell proliferation [GO:0008283]; cellular response to cAMP [GO:0071320]; establishment of endothelial barrier [GO:0061028]; negative regulation of syncytium formation by plasma membrane fusion [GO:0034242]; positive regulation of angiogenesis [GO:0045766]; positive regulation of GTPase activity [GO:0043547]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of protein acetylation [GO:1901985]; positive regulation of protein export from nucleus [GO:0046827]; positive regulation of stress fiber assembly [GO:0051496]; positive regulation of syncytium formation by plasma membrane fusion [GO:0060143]; Rap protein signal transduction [GO:0032486]; regulation of actin cytoskeleton reorganization [GO:2000249]; regulation of insulin secretion [GO:0050796]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O95398-1; Sequence=Displayed; Name=2; IsoId=O95398-2; Sequence=VSP_007608, VSP_007609; Name=3; IsoId=O95398-3; Sequence=VSP_047007; Note=Gene prediction based on EST data.; 


uniprotID: Q8WZA2
geneSymbol: RAPGEF4
reactome: R-HSA-354192;R-HSA-381676;R-HSA-392517;R-HSA-422356;
length: 1011
go: ENSG00000091428;
location: SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
name:
Rap guanine nucleotide exchange factor 4 (Exchange factor directly activated by cAMP 2) (Exchange protein directly activated by cAMP 2) (EPAC 2) (cAMP-regulated guanine nucleotide exchange factor II) (cAMP-GEFII)

sequence:

opentargets:
cytosol [GO:0005829]; hippocampal mossy fiber to CA3 synapse [GO:0098686]; membrane [GO:0016020]; plasma membrane [GO:0005886]; cAMP binding [GO:0030552]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras GTPase binding [GO:0017016]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; calcium ion regulated exocytosis [GO:0017156]; cAMP-mediated signaling [GO:0019933]; G protein-coupled receptor signaling pathway [GO:0007186]; insulin secretion [GO:0030073]; regulation of exocytosis [GO:0017157]; regulation of insulin secretion [GO:0050796]; regulation of synaptic vesicle cycle [GO:0098693]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q8WZA2-1; Sequence=Displayed; Note=Produced by alternative promoter usage. Promoter analysis was carried out in mouse.; Name=2; IsoId=Q8WZA2-2; Sequence=VSP_007611; Note=Produced by alternative promoter usage. Promoter analysis was carried out in mouse.; Name=3; IsoId=Q8WZA2-3; Sequence=VSP_007612, VSP_007613; Note=Produced by alternative splicing of isoform 1. No experimental confirmation available.; Name=4; IsoId=Q8WZA2-4; Sequence=VSP_054423; Note=No experimental confirmation available.; Name=5; IsoId=Q8WZA2-5; Sequence=VSP_054423, VSP_054424; Note=No experimental confirmation available.; 


uniprotID: Q92565
geneSymbol: RAPGEF5
pdb: 1WGY;
length: 580
go: ENSG00000136237;
location: SUBCELLULAR LOCATION: Nucleus.
name:
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)

sequence:

opentargets:
nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; GTP-dependent protein binding [GO:0030742]; Rap guanyl-nucleotide exchange factor activity [GO:0017034]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; nervous system development [GO:0007399]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q92565-1; Sequence=Displayed; Name=2; IsoId=Q92565-2; Sequence=VSP_007616; Note=No experimental confirmation available.; 


uniprotID: Q8TEU7
geneSymbol: RAPGEF6
pdb: 2D93;3LNY;
length: 1601
go: ENSG00000158987;
snps: rs3756293 rs34112735 rs7717835 rs1291602 rs1064539
name:
Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2)

sequence:

opentargets:
apical plasma membrane [GO:0016324]; centrosome [GO:0005813]; cytosol [GO:0005829]; endocytic vesicle [GO:0030139]; plasma membrane [GO:0005886]; GTP-dependent protein binding [GO:0030742]; guanyl-nucleotide exchange factor activity [GO:0005085]; phosphatidic acid binding [GO:0070300]; Ras GTPase binding [GO:0017016]; microvillus assembly [GO:0030033]; positive regulation of GTPase activity [GO:0043547]; protein localization to plasma membrane [GO:0072659]; Ras protein signal transduction [GO:0007265]; regulation of GTPase activity [GO:0043087]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; Synonyms=PDZ-GEF2A {ECO:0000269|PubMed:12581858}; IsoId=Q8TEU7-1; Sequence=Displayed; Name=2; Synonyms=PDZ-GEF2B {ECO:0000269|PubMed:12581858}; IsoId=Q8TEU7-2; Sequence=VSP_050610, VSP_050611; Name=3; IsoId=Q8TEU7-3; Sequence=VSP_050607, VSP_050608, VSP_050609; Name=4; IsoId=Q8TEU7-4; Sequence=VSP_050608; Note=No experimental confirmation available.; Name=5; IsoId=Q8TEU7-5; Sequence=VSP_050608, VSP_050609; Name=6; IsoId=Q8TEU7-6; Sequence=VSP_045027; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.


uniprotID: Q9UHV5
geneSymbol: RAPGEFL1
pdb: 2DHZ;
length: 662
go: ENSG00000108352;
name:
Rap guanine nucleotide exchange factor-like 1 (Link guanine nucleotide exchange factor II) (Link GEFII)

sequence:

opentargets:
intracellular [GO:0005622]; membrane [GO:0016020]; guanyl-nucleotide exchange factor activity [GO:0005085]; G protein-coupled receptor signaling pathway [GO:0007186]; nervous system development [GO:0007399]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9UHV5-1; Sequence=Displayed; Name=2; IsoId=Q9UHV5-2; Sequence=VSP_035217; Name=3; IsoId=Q9UHV5-3; Sequence=VSP_035385, VSP_035386; 


uniprotID: P47736
geneSymbol: RAP1GAP
reactome: R-HSA-392517;R-HSA-8853659;
pdb: 1SRQ;3BRW;
name: Rap1 GTPase-activating protein 1 (Rap1GAP) (Rap1GAP1)
length: 663
go: ENSG00000076864;
snps: rs2275363 rs147394161
location: SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein.
sequence:

opentargets:
cytosol [GO:0005829]; Golgi membrane [GO:0000139]; membrane [GO:0016020]; GTPase activator activity [GO:0005096]; GTPase activity [GO:0003924]; protein homodimerization activity [GO:0042803]; Ras GTPase binding [GO:0017016]; axon guidance [GO:0007411]; negative regulation of microvillus assembly [GO:1903697]; positive regulation of GTPase activity [GO:0043547]; regulation of GTPase activity [GO:0043087]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P47736-1; Sequence=Displayed; Name=2; IsoId=P47736-2; Sequence=VSP_035256, VSP_035257; Name=3; IsoId=P47736-3; Sequence=VSP_040260, VSP_040261; Name=4; IsoId=P47736-4; Sequence=VSP_047025; Note=No experimental confirmation available.; 


uniprotID: Q684P5
geneSymbol: RAP1GAP2
reactome: R-HSA-392517;
name: Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4)
length: 730
go: ENSG00000132359;
snps: rs17762452
sequence:

opentargets:
centrosome [GO:0005813]; cytosol [GO:0005829]; neuron projection [GO:0043005]; nuclear membrane [GO:0031965]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; negative regulation of neuron projection development [GO:0010977]; regulation of cell size [GO:0008361]; regulation of small GTPase mediated signal transduction [GO:0051056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=Rap1GAP2b; IsoId=Q684P5-1; Sequence=Displayed; Name=2; Synonyms=Rap1GAP2a; IsoId=Q684P5-2; Sequence=VSP_029889; Name=3; Synonyms=Rap1GAP2c; IsoId=Q684P5-3; Sequence=VSP_029888; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15632203}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15632203}.


uniprotID: Q96KN7
geneSymbol: RPGRIP1
pdb: 4QAM;
name: X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 (RPGR-interacting protein 1)
length: 1286
go: ENSG00000092200;
sequence:

opentargets:
axoneme [GO:0005930]; photoreceptor connecting cilium [GO:0032391]; eye photoreceptor cell development [GO:0042462]; neural precursor cell proliferation [GO:0061351]; response to stimulus [GO:0050896]; retina development in camera-type eye [GO:0060041]; visual perception [GO:0007601]

snps:
rs1040904 rs6571751 rs190985984 rs10151259 rs147586703 rs34067949 rs74034910 rs3748360 rs3748360 rs200325360 rs1010290273 rs61751268 rs758652031 rs142796310 rs372647080 rs28937883 rs373515194 rs772480252 rs181758389 rs61751274 rs35810926 rs3748361 rs201521970 rs17103671 rs34725281 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q96KN7-1; Sequence=Displayed; Name=2; Synonyms=a; IsoId=Q96KN7-2; Sequence=VSP_009521, VSP_009525; Name=3; Synonyms=b; IsoId=Q96KN7-3; Sequence=VSP_009522, VSP_009526; Name=4; IsoId=Q96KN7-4; Sequence=VSP_009519, VSP_009523, VSP_009524; Name=5; IsoId=Q96KN7-5; Sequence=VSP_009520; Name=6; IsoId=Q96KN7-6; Sequence=VSP_009520, VSP_009527; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:21685204}. Note=Situated between the axonemal microtubules and the plasma membrane. {ECO:0000250|UniProtKB:Q9EPQ2}.


uniprotID: Q9UNE2
geneSymbol: RPH3AL
name: Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)
length: 315
go: ENSG00000181031;
sequence:

opentargets:
cytoplasm [GO:0005737]; secretory granule membrane [GO:0030667]; transport vesicle membrane [GO:0030658]; cytoskeletal protein binding [GO:0008092]; LIM domain binding [GO:0030274]; metal ion binding [GO:0046872]; Rab GTPase binding [GO:0017137]; exocytosis [GO:0006887]; glucose homeostasis [GO:0042593]; intracellular protein transport [GO:0006886]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; positive regulation of protein secretion [GO:0050714]; regulation of calcium ion-dependent exocytosis [GO:0017158]; response to drug [GO:0042493]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9UNE2-1; Sequence=Displayed; Name=2; IsoId=Q9UNE2-2; Sequence=VSP_023244; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15003533}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:15003533}. Note=Recruited to the vesicle membrane in a GTP- and RAB3B-dependent manner in epithelial cells.


uniprotID: Q8TAA1
geneSymbol: RNASE11
name: Probable ribonuclease 11 (RNase 11) (EC 3.1.27.-)
length: 199
snps: rs17113756 rs35818240
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:
METFPLLLLSLGLVLAEASESTMKIIKEEFTDEEMQYDMAKSGQEKQTIEILMNPILLVKNTSLSMSKDDMSSTLLTFRSLHYNDPKGNSSGNDKECCNDMTVWRKVSEANGSCKWSNNFIRSSTEVMRRVHRAPSCKFVQNPGISCCESLELENTVCQFTTGKQFPRCQYHSVTSLEKILTVLTGHSLMSWLVCGSKL

opentargets:
extracellular region [GO:0005576]; endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]; RNA phosphodiester bond hydrolysis [GO:0090501]


uniprotID: P35268
geneSymbol: RPL22
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
length: 128
go: ENSG00000116251;
name:
60S ribosomal protein L22 (EBER-associated protein) (EAP) (Epstein-Barr virus small RNA-associated protein) (Heparin-binding protein HBp15) (Large ribosomal subunit protein eL22)

sequence:
MAPVKKLVVKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEVPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; heparin binding [GO:0008201]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P62829
geneSymbol: RPL23
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L23 (60S ribosomal protein L17) (Large ribosomal subunit protein uL14)
length: 140
go: ENSG00000125691;
drug: DB02494;DB07374;DB08437;
sequence:
MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; protein-containing complex [GO:0032991]; ribosome [GO:0005840]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; transcription coactivator binding [GO:0001223]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]; cellular response to actinomycin D [GO:0072717]; negative regulation of cell cycle arrest [GO:0071157]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of cell proliferation [GO:0008284]; positive regulation of gene expression [GO:0010628]; positive regulation of signal transduction by p53 class mediator [GO:1901798]; protein stabilization [GO:0050821]; protein-DNA complex disassembly [GO:0032986]; ribosomal protein import into nucleus [GO:0006610]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q13464
geneSymbol: ROCK1
length: 1354
go: ENSG00000067900;
drug: DB08756;DB07876;DB04707;
snps: rs55811609 rs45562542 rs35881519 rs1057520015 rs2847092 rs1045142 rs2663698
reactome:
R-HSA-111465;R-HSA-3928662;R-HSA-3928663;R-HSA-416482;R-HSA-416572;R-HSA-4420097;R-HSA-5627117;R-HSA-6798695;

pdb:
1S1C;2ESM;2ETK;2ETR;2V55;3D9V;3NCZ;3NDM;3O0Z;3TV7;3TWJ;3V8S;4L2W;4W7P;4YVC;4YVE;5BML;5F5P;5HVU;5KKS;5KKT;5UZJ;5WNE;5WNF;5WNG;5WNH;

name:
Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK)

sequence:

opentargets:
bleb [GO:0032059]; centriole [GO:0005814]; cytoplasmic stress granule [GO:0010494]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular region [GO:0005576]; Golgi membrane [GO:0000139]; lamellipodium [GO:0030027]; plasma membrane [GO:0005886]; ruffle [GO:0001726]; secretory granule lumen [GO:0034774]; ATP binding [GO:0005524]; GTP-Rho binding [GO:0017049]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; actin cytoskeleton organization [GO:0030036]; aortic valve morphogenesis [GO:0003180]; apical constriction [GO:0003383]; apoptotic process [GO:0006915]; bleb assembly [GO:0032060]; cortical actin cytoskeleton organization [GO:0030866]; ephrin receptor signaling pathway [GO:0048013]; G protein-coupled receptor signaling pathway [GO:0007186]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; leukocyte tethering or rolling [GO:0050901]; membrane to membrane docking [GO:0022614]; myoblast migration [GO:0051451]; negative regulation of amyloid precursor protein catabolic process [GO:1902992]; negative regulation of amyloid-beta formation [GO:1902430]; negative regulation of angiogenesis [GO:0016525]; negative regulation of bicellular tight junction assembly [GO:1903347]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of membrane protein ectodomain proteolysis [GO:0051045]; negative regulation of myosin-light-chain-phosphatase activity [GO:0035509]; negative regulation of neuron apoptotic process [GO:0043524]; negative regulation of protein binding [GO:0032091]; neuron projection arborization [GO:0140058]; neuron projection development [GO:0031175]; neutrophil degranulation [GO:0043312]; positive regulation of amyloid-beta clearance [GO:1900223]; positive regulation of autophagy [GO:0010508]; positive regulation of cardiac muscle hypertrophy [GO:0010613]; positive regulation of connective tissue replacement [GO:1905205]; positive regulation of focal adhesion assembly [GO:0051894]; positive regulation of gene expression [GO:0010628]; positive regulation of MAPK cascade [GO:0043410]; protein localization to plasma membrane [GO:0072659]; protein phosphorylation [GO:0006468]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of amyloid-beta formation [GO:1902003]; regulation of angiotensin-activated signaling pathway [GO:0110061]; regulation of autophagy [GO:0010506]; regulation of cell adhesion [GO:0030155]; regulation of cell motility [GO:2000145]; regulation of establishment of cell polarity [GO:2000114]; regulation of establishment of endothelial barrier [GO:1903140]; regulation of focal adhesion assembly [GO:0051893]; regulation of keratinocyte differentiation [GO:0045616]; regulation of neuron differentiation [GO:0045664]; regulation of stress fiber assembly [GO:0051492]; regulation of synaptic vesicle endocytosis [GO:1900242]; response to angiotensin [GO:1990776]; response to transforming growth factor beta [GO:0071559]; Rho protein signal transduction [GO:0007266]; signal transduction [GO:0007165]; smooth muscle contraction [GO:0006939]; vascular endothelial growth factor receptor signaling pathway [GO:0048010]

location:
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Note=Associated with the mother centriole and an intercentriolar linker. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity). A small proportion is associated with Golgi membranes. {ECO:0000250}.


uniprotID: P60602
geneSymbol: ROMO1
sequence: MPVAVGPYGQSQPSCFDRVKMGFVMGCAVGMAAGALFGTFSCLRIGMRGRELMGGIGKTMMQSGGTFGTFMAIGMGIRC
length: 79
go: ENSG00000125995;
snps: rs1044521
name:
Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog)

opentargets:
integral component of membrane [GO:0016021]; mitochondrion [GO:0005739]; TIM23 mitochondrial import inner membrane translocase complex [GO:0005744]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cellular response to reactive oxygen species [GO:0034614]; cytolysis in other organism [GO:0051715]; defense response to bacterium [GO:0042742]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; killing of cells of other organism [GO:0031640]; positive regulation of cell proliferation [GO:0008284]; positive regulation of reactive oxygen species metabolic process [GO:2000379]; protein import into mitochondrial inner membrane [GO:0045039]; protein import into mitochondrial matrix [GO:0030150]; replicative cell aging [GO:0001302]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P60602-1; Sequence=Displayed; Name=2; IsoId=P60602-2; Sequence=VSP_036486; Note=Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}; Single-pass membrane protein {ECO:0000269|PubMed:16842742, ECO:0000269|PubMed:19535734}.


uniprotID: Q9HAT0
geneSymbol: ROPN1
reactome: R-HSA-5666185;
name: Ropporin-1A (Cancer/testis antigen 91) (CT91) (Rhophilin-associated protein 1A)
length: 212
go: ENSG00000065371;
sequence:

opentargets:
cytoplasm [GO:0005737]; motile cilium [GO:0031514]; nucleus [GO:0005634]; identical protein binding [GO:0042802]; cilium organization [GO:0044782]; flagellated sperm motility [GO:0030317]; protein localization to cilium [GO:0061512]; regulation of protein phosphorylation [GO:0001932]; sperm capacitation [GO:0048240]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9HAT0-1; Sequence=Displayed; Name=2; IsoId=Q9HAT0-2; Sequence=VSP_028743, VSP_028744; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250|UniProtKB:Q9ESG2}.


uniprotID: Q9BZX4
geneSymbol: ROPN1B
name: Ropporin-1B (Rhophilin-associated protein 1B)
length: 212
go: ENSG00000114547;
sequence:

opentargets:
cytoplasm [GO:0005737]; motile cilium [GO:0031514]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; receptor signaling complex scaffold activity [GO:0030159]; acrosome reaction [GO:0007340]; cell-cell adhesion [GO:0098609]; cilium organization [GO:0044782]; cytoskeleton-dependent cytokinesis [GO:0061640]; flagellated sperm motility [GO:0030317]; fusion of sperm to egg plasma membrane involved in single fertilization [GO:0007342]; protein localization to cilium [GO:0061512]; regulation of protein phosphorylation [GO:0001932]; Rho protein signal transduction [GO:0007266]; sperm capacitation [GO:0048240]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BZX4-1; Sequence=Displayed; Name=2; IsoId=Q9BZX4-2; Sequence=VSP_028745; 

location:
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9ESG2}. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250|UniProtKB:Q9ESG2}.


uniprotID: P35398
geneSymbol: RORA
reactome: R-HSA-1368082;R-HSA-1989781;R-HSA-383280;R-HSA-400253;R-HSA-4090294;R-HSA-6785807;
pdb: 1N83;1S0X;4S15;
length: 523
go: ENSG00000069667;
drug: DB04540;DB01990;
name:
Nuclear receptor ROR-alpha (Nuclear receptor RZR-alpha) (Nuclear receptor subfamily 1 group F member 1) (RAR-related orphan receptor A) (Retinoid-related orphan receptor-alpha)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; beta-catenin binding [GO:0008013]; DNA binding [GO:0003677]; DNA-binding transcription activator activity, RNA polymerase II-specific [GO:0001228]; DNA-binding transcription factor activity [GO:0003700]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; oxysterol binding [GO:0008142]; RNA polymerase II proximal promoter sequence-specific DNA binding [GO:0000978]; RNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977]; sequence-specific DNA binding [GO:0043565]; steroid hormone receptor activity [GO:0003707]; transcription coactivator binding [GO:0001223]; transcription corepressor binding [GO:0001222]; transcription factor activity, direct ligand regulated sequence-specific DNA binding [GO:0098531]; transcription factor binding [GO:0008134]; zinc ion binding [GO:0008270]; angiogenesis [GO:0001525]; cellular response to hypoxia [GO:0071456]; cellular response to interleukin-1 [GO:0071347]; cellular response to sterol [GO:0036315]; cellular response to tumor necrosis factor [GO:0071356]; cerebellar granule cell precursor proliferation [GO:0021930]; cerebellar Purkinje cell differentiation [GO:0021702]; cGMP metabolic process [GO:0046068]; cholesterol homeostasis [GO:0042632]; circadian regulation of gene expression [GO:0032922]; cytokine-mediated signaling pathway [GO:0019221]; intracellular receptor signaling pathway [GO:0030522]; muscle cell differentiation [GO:0042692]; negative regulation of fat cell differentiation [GO:0045599]; negative regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043124]; negative regulation of inflammatory response [GO:0050728]; nitric oxide biosynthetic process [GO:0006809]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of glucose metabolic process [GO:0010906]; regulation of macrophage activation [GO:0043030]; regulation of smoothened signaling pathway [GO:0008589]; regulation of steroid metabolic process [GO:0019218]; regulation of transcription involved in cell fate commitment [GO:0060850]; regulation of transcription, DNA-templated [GO:0006355]; T-helper 17 cell differentiation [GO:0072539]; transcription initiation from RNA polymerase II promoter [GO:0006367]; triglyceride homeostasis [GO:0070328]; xenobiotic metabolic process [GO:0006805]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative promoter usage, Alternative splicing; Named isoforms=4;  Name=1; Synonyms=Alpha-1; IsoId=P35398-2; Sequence=Displayed; Name=2; Synonyms=Alpha-2; IsoId=P35398-1; Sequence=VSP_053973; Note=Produced by alternative promoter usage. Region from 23 to 71 inhibits DNA-binding and transactivation activity.; Name=3; Synonyms=Alpha-3; IsoId=P35398-3; Sequence=VSP_053975; Note=Produced by alternative splicing.; Name=4; Synonyms=Alpha-4; IsoId=P35398-4; Sequence=VSP_053974; Note=Produced by alternative promoter usage. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:18005000, ECO:0000269|PubMed:18354202, ECO:0000269|PubMed:18658046}.


uniprotID: Q8N5L8
geneSymbol: RPP25L
length: 163
go: ENSG00000164967;
opentargets: nucleus [GO:0005634]; RNA binding [GO:0003723]
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Ribonuclease P protein subunit p25-like protein (RNase P protein subunit-like p25) (Rpp25-like protein)

sequence:
MEHYRKAGSVELPAPSPMPQLPPDTLEMRVRDGSKIRNLLGLALGRLEGGSARHVVFSGSGRAAGKAVSCAEIVKRRVPGLHQLTKLRFLQTEDSWVPASPDTGLDPLTVRRHVPAVWVLLSRDPLDPNECGYQPPGAPPGLGSMPSSSCGPRSRRRARDTRS


uniprotID: Q8TA86
geneSymbol: RP9
name: Retinitis pigmentosa 9 protein (Pim-1-associated protein) (PAP-1)
length: 221
go: ENSG00000164610;
snps: rs104894037 rs104894039 rs150987618
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; signal recognition particle receptor complex [GO:0005785]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; cognition [GO:0050890]; RNA splicing [GO:0008380]


uniprotID: P05423
geneSymbol: POLR3D
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 398
go: ENSG00000168495;
location: SUBCELLULAR LOCATION: Nucleus.
name:
DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)

sequence:

opentargets:
cytosol [GO:0005829]; nuclear chromatin [GO:0000790]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; RNA polymerase III complex [GO:0005666]; chromatin binding [GO:0003682]; DNA binding [GO:0003677]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; positive regulation of innate immune response [GO:0045089]; positive regulation of interferon-beta production [GO:0032728]; transcription by RNA polymerase III [GO:0006383]


uniprotID: Q9NVU0
geneSymbol: POLR3E
reactome: R-HSA-1834949;R-HSA-73780;R-HSA-73980;R-HSA-749476;R-HSA-76061;R-HSA-76066;R-HSA-76071;
length: 708
go: ENSG00000058600;
snps: rs2347
location: SUBCELLULAR LOCATION: Nucleus.
name:
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase III complex [GO:0005666]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; transcription by RNA polymerase III [GO:0006383]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9NVU0-1; Sequence=Displayed; Name=2; IsoId=Q9NVU0-2; Sequence=VSP_007065; Name=3; IsoId=Q9NVU0-3; Sequence=VSP_007064; Note=No experimental confirmation available. May result from the retention of an intron in the cDNA.; Name=4; IsoId=Q9NVU0-4; Sequence=VSP_044710; Note=No experimental confirmation available.; Name=5; IsoId=Q9NVU0-5; Sequence=VSP_046374; Note=No experimental confirmation available.; 


uniprotID: P46779
geneSymbol: RPL28
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L28 (Large ribosomal subunit protein eL28)
length: 137
go: ENSG00000108107;
snps: rs13502
sequence:
MSAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGVEPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNKYRPDLRMAAIRRASAILRSQKPVMVKRKRTRPTKSS

opentargets:
cell body [GO:0044297]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=P46779-1; Sequence=Displayed; Name=2; IsoId=P46779-2; Sequence=VSP_043026; Note=No experimental confirmation available.; Name=3; IsoId=P46779-3; Sequence=VSP_046173; Note=No experimental confirmation available.; Name=4; IsoId=P46779-4; Sequence=VSP_047026; Note=No experimental confirmation available. Gene prediction based on EST data.; Name=5; IsoId=P46779-5; Sequence=VSP_047027; Note=No experimental confirmation available. Gene prediction based on EST data.; 


uniprotID: Q9H7B2
geneSymbol: RPF2
length: 306
go: ENSG00000197498;
snps: rs9320350 rs6909298
name:
Ribosome production factor 2 homolog (Brix domain-containing protein 1) (Ribosome biogenesis protein RPF2 homolog)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19170763}. Note=Associated with the nucleolus in an RNA-dependent manner.


uniprotID: Q13905
geneSymbol: RAPGEF1
reactome: R-HSA-170968;R-HSA-186763;R-HSA-8875555;R-HSA-912631;
pdb: 5L23;
length: 1077
go: ENSG00000107263;
location: SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:17724123}.
name:
Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; early endosome [GO:0005769]; endosome [GO:0005768]; perinuclear region of cytoplasm [GO:0048471]; phagocytic vesicle membrane [GO:0030670]; protein-containing complex [GO:0032991]; guanyl-nucleotide exchange factor activity [GO:0005085]; Rap guanyl-nucleotide exchange factor activity [GO:0017034]; SH3 domain binding [GO:0017124]; activation of MAPKK activity [GO:0000186]; blood vessel development [GO:0001568]; cell-cell adhesion [GO:0098609]; cellular response to cAMP [GO:0071320]; cellular response to nerve growth factor stimulus [GO:1990090]; cytokine-mediated signaling pathway [GO:0019221]; establishment of endothelial barrier [GO:0061028]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of ERK1 and ERK2 cascade [GO:0070373]; negative regulation of neural precursor cell proliferation [GO:2000178]; negative regulation of protein kinase B signaling [GO:0051898]; negative regulation of Ras protein signal transduction [GO:0046580]; nerve growth factor signaling pathway [GO:0038180]; platelet-derived growth factor receptor signaling pathway [GO:0048008]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis [GO:1905451]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron projection development [GO:0010976]; Rap protein signal transduction [GO:0032486]; regulation of cell junction assembly [GO:1901888]; regulation of JNK cascade [GO:0046328]; signal transduction [GO:0007165]; transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=Long; IsoId=Q13905-1; Sequence=Displayed; Name=Short; IsoId=Q13905-2; Sequence=VSP_001822; Name=3; IsoId=Q13905-3; Sequence=VSP_042052; Note=No experimental confirmation available.; Name=4; IsoId=Q13905-4; Sequence=VSP_057416; Note=No experimental confirmation available.; 


uniprotID: Q92878
geneSymbol: RAD50
pdb: 5GOX;
name: DNA repair protein RAD50 (hRAD50) (EC 3.6.-.-)
length: 1312
go: ENSG00000113522;
reactome:
R-HSA-2559586;R-HSA-5685938;R-HSA-5685939;R-HSA-5685942;R-HSA-5693548;R-HSA-5693554;R-HSA-5693565;R-HSA-5693568;R-HSA-5693571;R-HSA-5693579;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;R-HSA-912446;

sequence:

opentargets:
condensed nuclear chromosome [GO:0000794]; membrane [GO:0016020]; Mre11 complex [GO:0030870]; nuclear chromatin [GO:0000790]; nuclear chromosome, telomeric region [GO:0000784]; nucleoplasm [GO:0005654]; site of double-strand break [GO:0035861]; adenylate kinase activity [GO:0004017]; ATP binding [GO:0005524]; ATPase activity [GO:0016887]; DNA binding [GO:0003677]; double-stranded telomeric DNA binding [GO:0003691]; G-quadruplex DNA binding [GO:0051880]; metal ion binding [GO:0046872]; protein binding, bridging [GO:0030674]; single-stranded telomeric DNA binding [GO:0043047]; cellular response to DNA damage stimulus [GO:0006974]; chromosome organization involved in meiotic cell cycle [GO:0070192]; DNA double-strand break processing [GO:0000729]; DNA duplex unwinding [GO:0032508]; DNA recombination [GO:0006310]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; double-strand break repair [GO:0006302]; double-strand break repair via homologous recombination [GO:0000724]; double-strand break repair via nonhomologous end joining [GO:0006303]; negative regulation of telomere capping [GO:1904354]; nucleic acid phosphodiester bond hydrolysis [GO:0090305]; positive regulation of kinase activity [GO:0033674]; positive regulation of protein autophosphorylation [GO:0031954]; positive regulation of telomere maintenance [GO:0032206]; reciprocal meiotic recombination [GO:0007131]; regulation of mitotic recombination [GO:0000019]; telomere capping [GO:0016233]; telomere maintenance [GO:0000723]; telomere maintenance via recombination [GO:0000722]; telomere maintenance via telomerase [GO:0007004]; telomeric 3' overhang formation [GO:0031860]; viral process [GO:0016032]

snps:
rs28903085 rs28903086 rs2230017 rs28903087 rs28903088 rs28903090 rs55653181 rs1047380 rs1047382 rs28903093 rs1047386 rs1129482 rs1047387 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=RAD50-1, RAD50-2; IsoId=Q92878-1; Sequence=Displayed; Name=2; IsoId=Q92878-2; Sequence=VSP_012591; Name=3; Synonyms=RAD50-3; IsoId=Q92878-3; Sequence=VSP_012590; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093}. Chromosome, telomere {ECO:0000269|PubMed:10888888}. Chromosome {ECO:0000269|PubMed:26215093}. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents. {ECO:0000269|PubMed:10783165, ECO:0000269|PubMed:15916964, ECO:0000269|PubMed:26215093}.


uniprotID: Q8IZV5
geneSymbol: RDH10
reactome: R-HSA-2453902;R-HSA-5365859;
name: Retinol dehydrogenase 10 (EC 1.1.1.300) (Short chain dehydrogenase/reductase family 16C member 4)
length: 341
go: ENSG00000121039;
sequence:

opentargets:
cell body [GO:0044297]; cytoplasm [GO:0005737]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; lipid droplet [GO:0005811]; organelle membrane [GO:0031090]; NADP-retinol dehydrogenase activity [GO:0052650]; retinol dehydrogenase activity [GO:0004745]; bud elongation involved in lung branching [GO:0060449]; ear development [GO:0043583]; embryonic camera-type eye development [GO:0031076]; embryonic forelimb morphogenesis [GO:0035115]; embryonic viscerocranium morphogenesis [GO:0048703]; gonad development [GO:0008406]; in utero embryonic development [GO:0001701]; metanephros development [GO:0001656]; neural crest cell development [GO:0014032]; nose development [GO:0043584]; primary lung bud formation [GO:0060431]; retinal metabolic process [GO:0042574]; retinoic acid biosynthetic process [GO:0002138]; retinoid metabolic process [GO:0001523]; retinol metabolic process [GO:0042572]; visual perception [GO:0007601]

location:
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.


uniprotID: Q96I51
geneSymbol: RCC1L
pdb: 5XGS;
length: 464
snps: rs6955671
name:
RCC1-like G exchanging factor-like protein (RCC1-like) (Williams-Beuren syndrome chromosomal region 16 protein)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial membrane [GO:0031966]; GTP binding [GO:0005525]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; mitochondrial membrane fusion [GO:1990613]; positive regulation of mitochondrial translation [GO:0070131]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96I51-1; Sequence=Displayed; Name=2; IsoId=Q96I51-2; Sequence=VSP_055617, VSP_055618; Note=No experimental confirmation available.; Name=3; IsoId=Q96I51-3; Sequence=VSP_055619; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:28608466, ECO:0000269|PubMed:28746876}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CYF5}.


uniprotID: Q5TC82
geneSymbol: RC3H1
pdb: 3X1O;4QIK;4QIL;4ULW;4YWQ;
length: 1133
go: ENSG00000135870;
name:
Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198)

sequence:

opentargets:
cytoplasmic stress granule [GO:0010494]; P-body [GO:0000932]; double-stranded RNA binding [GO:0003725]; miRNA binding [GO:0035198]; mRNA 3'-UTR binding [GO:0003730]; RNA binding [GO:0003723]; RNA stem-loop binding [GO:0035613]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; 3'-UTR-mediated mRNA destabilization [GO:0061158]; B cell homeostasis [GO:0001782]; cellular response to interleukin-1 [GO:0071347]; cytoplasmic mRNA processing body assembly [GO:0033962]; lymph node development [GO:0048535]; negative regulation of activated T cell proliferation [GO:0046007]; negative regulation of B cell proliferation [GO:0030889]; negative regulation of germinal center formation [GO:0002635]; negative regulation of T-helper 17 cell differentiation [GO:2000320]; negative regulation of T-helper cell differentiation [GO:0045623]; nuclear-transcribed mRNA catabolic process [GO:0000956]; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [GO:0000288]; positive regulation of mRNA catabolic process [GO:0061014]; positive regulation of NIK/NF-kappaB signaling [GO:1901224]; posttranscriptional regulation of gene expression [GO:0010608]; protein polyubiquitination [GO:0000209]; regulation of germinal center formation [GO:0002634]; regulation of miRNA metabolic process [GO:2000628]; regulation of mRNA stability [GO:0043488]; regulation of T cell receptor signaling pathway [GO:0050856]; spleen development [GO:0048536]; T cell homeostasis [GO:0043029]; T cell proliferation [GO:0042098]; T cell receptor signaling pathway [GO:0050852]; T follicular helper cell differentiation [GO:0061470]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q5TC82-1; Sequence=Displayed; Name=2; IsoId=Q5TC82-2; Sequence=VSP_015015, VSP_015016; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000250|UniProtKB:Q4VGL6}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q4VGL6}. Note=During stress, such as that induced by arsenite treatment, localizes to cytosolic stress granules (By similarity). Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger (By similarity). ICOS repression may correlate with the localization to P-bodies, not to stress granules (By similarity). {ECO:0000250|UniProtKB:Q4VGL6}.


uniprotID: Q9Y3P4
geneSymbol: RHBDD3
name: Rhomboid domain-containing protein 3
length: 386
go: ENSG00000100263;
snps: rs2272902 rs2231397
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; intracellular [GO:0005622]; serine-type endopeptidase activity [GO:0004252]; liver development [GO:0001889]; MAPK cascade [GO:0000165]; negative regulation of natural killer cell activation [GO:0032815]; positive regulation of protein catabolic process [GO:0045732]; regulation of acute inflammatory response [GO:0002673]; regulation of protein secretion [GO:0050708]; response to xenobiotic stimulus [GO:0009410]


uniprotID: A7KAX9
geneSymbol: ARHGAP32
reactome: R-HSA-194840;
pdb: 3IUG;
length: 2087
go: ENSG00000134909;
name:
Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

sequence:

opentargets:
actin cytoskeleton [GO:0015629]; cell cortex [GO:0005938]; cell junction [GO:0030054]; cytosol [GO:0005829]; dendritic spine [GO:0043197]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; fibrillar center [GO:0001650]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; nucleoplasm [GO:0005654]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; GTPase activator activity [GO:0005096]; phosphatidylinositol binding [GO:0035091]; regulation of small GTPase mediated signal transduction [GO:0051056]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=PX-RICS; IsoId=A7KAX9-1; Sequence=Displayed; Name=2; IsoId=A7KAX9-2; Sequence=VSP_034933; Name=3; IsoId=A7KAX9-3; Sequence=VSP_034934, VSP_034935, VSP_034936; 

location:
SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q811P8}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q811P8}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12446789}. Endosome membrane {ECO:0000269|PubMed:17663722}. Golgi apparatus membrane {ECO:0000269|PubMed:17663722}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q811P8}. Membrane {ECO:0000269|PubMed:17663722}. Note=Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203). {ECO:0000250|UniProtKB:Q811P8, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:17663722}.


uniprotID: Q9H4K1
geneSymbol: RIBC2
name: RIB43A-like with coiled-coils protein 2
length: 309
opentargets: nucleus [GO:0005634]
snps: rs2142661 rs1022478 rs2072770
sequence:


uniprotID: Q969X0
geneSymbol: RILPL2
name: RILP-like protein 2 (Rab-interacting lysosomal protein-like 2) (p40phox-binding protein)
length: 211
go: ENSG00000150977;
sequence:

opentargets:
centrosome [GO:0005813]; ciliary basal body [GO:0036064]; cilium [GO:0005929]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; membrane [GO:0016020]; dynein light intermediate chain binding [GO:0051959]; identical protein binding [GO:0042802]; protein dimerization activity [GO:0046983]; small GTPase binding [GO:0031267]; cilium assembly [GO:0060271]; epithelial cell morphogenesis [GO:0003382]; protein transport from ciliary membrane to plasma membrane [GO:1903445]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14668488}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium {ECO:0000250}.


uniprotID: Q96TC7
geneSymbol: RMDN3
length: 470
go: ENSG00000137824;
snps: rs11558807
name:
Regulator of microtubule dynamics protein 3 (RMD-3) (hRMD-3) (Cerebral protein 10) (Protein FAM82A2) (Protein FAM82C) (Protein tyrosine phosphatase-interacting protein 51) (TCPTP-interacting protein 51)

sequence:

opentargets:
integral component of membrane [GO:0016021]; microtubule [GO:0005874]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; nucleus [GO:0005634]; spindle pole [GO:0000922]; apoptotic process [GO:0006915]; cell differentiation [GO:0030154]; cellular calcium ion homeostasis [GO:0006874]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96TC7-1; Sequence=Displayed; Name=2; IsoId=Q96TC7-2; Sequence=VSP_025531; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein. Mitochondrion outer membrane. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles.


uniprotID: Q96G75
geneSymbol: RMND5B
name: E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B)
length: 393
go: ENSG00000145916;
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25793641}.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; GID complex [GO:0034657]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96G75-1; Sequence=Displayed; Name=2; IsoId=Q96G75-2; Sequence=VSP_013174; Note=No experimental confirmation available.; 


uniprotID: Q96E14
geneSymbol: RMI2
pdb: 3MXN;3NBH;4DAY;
name: RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)
length: 147
go: ENSG00000175643;
reactome:
R-HSA-5685938;R-HSA-5685942;R-HSA-5693554;R-HSA-5693568;R-HSA-5693579;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;

sequence:
MAAAADSFSGGPAGVRLPRSPPLKVLAEQLRRDAEGGPGAWRLSRAAAGRGPLDLAAVWMQGRVVMADRGEARLRDPSGDFSVRGLERVPRGRPCLVPGKYVMVMGVVQACSPEPCLQAVKMTDLSDNPIHESMWELEVEDLHRNIP

opentargets:
cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; DNA binding [GO:0003677]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]; regulation of sister chromatid segregation [GO:0033045]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96E14-1; Sequence=Displayed; Name=2; IsoId=Q96E14-2; Sequence=VSP_027287; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18923082}. Note=Colocalizes with BLM at nuclear DNA repair foci.


uniprotID: Q9NWS8
geneSymbol: RMND1
name: Required for meiotic nuclear division protein 1 homolog
length: 449
go: ENSG00000155906;
snps: rs11550103 rs6934360 rs3734800 rs397515421
sequence:

opentargets:
mitochondrion [GO:0005739]; positive regulation of mitochondrial translation [GO:0070131]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9NWS8-1; Sequence=Displayed; Name=2; IsoId=Q9NWS8-2; Sequence=VSP_017735; Note=No experimental confirmation available.; Name=3; IsoId=Q9NWS8-3; Sequence=VSP_017738, VSP_017739; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23022098, ECO:0000269|PubMed:23022099, ECO:0000269|PubMed:25604853}. Note=May be localized in mitochondrial RNA granules (PubMed:25604853). {ECO:0000269|PubMed:25604853}.


uniprotID: O94763
geneSymbol: URI1
length: 535
go: ENSG00000105176;
snps: rs189187
name:
Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; mitochondrion [GO:0005739]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA polymerase II, core complex [GO:0005665]; chromatin binding [GO:0003682]; phosphatase inhibitor activity [GO:0019212]; phosphoprotein binding [GO:0051219]; protein phosphatase inhibitor activity [GO:0004864]; RNA polymerase II complex binding [GO:0000993]; transcription corepressor activity [GO:0003714]; cellular response to growth factor stimulus [GO:0071363]; cellular response to steroid hormone stimulus [GO:0071383]; negative regulation of intrinsic apoptotic signaling pathway [GO:2001243]; negative regulation of phosphatase activity [GO:0010923]; negative regulation of transcription by RNA polymerase II [GO:0000122]; regulation of cell growth [GO:0001558]; regulation of transcription by RNA polymerase II [GO:0006357]; response to virus [GO:0009615]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=O94763-1; Sequence=Displayed; Name=2; IsoId=O94763-2; Sequence=VSP_032773; Name=3; IsoId=O94763-3; Sequence=VSP_042259; Note=No experimental confirmation available.; Name=4; IsoId=O94763-4; Sequence=VSP_044769, VSP_044770; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Mitochondrion. Cell projection, dendrite {ECO:0000250}. Note=Colocalizes with PFDN2, PFDN4, PPP1CC, RPS6KB1 and STAP1 at mitochondrion.


uniprotID: Q96E39
geneSymbol: RBMXL1
name: RNA binding motif protein, X-linked-like-1 (Heterogeneous nuclear ribonucleoprotein G-like 1)
length: 390
go: ENSG00000213516;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
sequence:

opentargets:
ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]


uniprotID: O75526
geneSymbol: RBMXL2
length: 392
go: ENSG00000170748;
snps: rs17857474 rs11041170 rs11041171 rs17854944
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958650}.
name:
RNA-binding motif protein, X-linked-like-2 (Testis-specific heterogeneous nuclear ribonucleoprotein G-T) (hnRNP G-T)

sequence:

opentargets:
commitment complex [GO:0000243]; mRNA binding [GO:0003729]; mRNA splicing, via spliceosome [GO:0000398]


uniprotID: O00237
geneSymbol: RNF103
reactome: R-HSA-901032;
length: 685
go: ENSG00000239305;
name:
E3 ubiquitin-protein ligase RNF103 (EC 2.3.2.27) (KF-1) (hKF-1) (RING finger protein 103) (RING-type E3 ubiquitin transferase RNF103) (Zinc finger protein 103 homolog) (Zfp-103)

sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endoplasmic reticulum quality control compartment [GO:0044322]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; central nervous system development [GO:0007417]; endoplasmic reticulum mannose trimming [GO:1904380]; protein ubiquitination [GO:0016567]; ubiquitin-dependent ERAD pathway [GO:0030433]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18675248}; Multi-pass membrane protein {ECO:0000269|PubMed:18675248}.


uniprotID: Q6ZNA4
geneSymbol: RNF111
reactome: R-HSA-2173795;R-HSA-2173796;R-HSA-5696395;R-HSA-983168;
pdb: 2KIZ;5LG0;5LG7;
length: 994
go: ENSG00000157450;
snps: rs2899642 rs34086812
name:
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; SMAD binding [GO:0046332]; SUMO polymer binding [GO:0032184]; ubiquitin protein ligase activity [GO:0061630]; global genome nucleotide-excision repair [GO:0070911]; pattern specification process [GO:0007389]; positive regulation of protein ubiquitination [GO:0031398]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transforming growth factor beta receptor signaling pathway [GO:0030511]; protein polyubiquitination [GO:0000209]; protein ubiquitination [GO:0016567]; ubiquitin-dependent protein catabolic process [GO:0006511]; ubiquitin-dependent SMAD protein catabolic process [GO:0030579]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZNA4-1; Sequence=Displayed; Name=2; IsoId=Q6ZNA4-2; Sequence=VSP_023841; Name=3; IsoId=Q6ZNA4-3; Sequence=VSP_023840; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZNA4-4; Sequence=VSP_023840, VSP_023841; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:23751493}. Cytoplasm {ECO:0000269|PubMed:16601693}. Nucleus, PML body {ECO:0000250|UniProtKB:Q99ML9}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol. {ECO:0000269|PubMed:16601693}.


uniprotID: Q9ULX5
geneSymbol: RNF112
name: RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Zinc finger protein 179)
length: 631
go: ENSG00000128482;
sequence:

opentargets:
cell body [GO:0044297]; cell junction [GO:0030054]; cytoplasm [GO:0005737]; endosome [GO:0005768]; extrinsic component of membrane [GO:0019898]; integral component of membrane [GO:0016021]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density [GO:0014069]; postsynaptic membrane [GO:0045211]; synaptic vesicle [GO:0008021]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; protein self-association [GO:0043621]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; cell cycle arrest [GO:0007050]; cell death in response to hydrogen peroxide [GO:0036474]; cell death in response to oxidative stress [GO:0036473]; embryonic brain development [GO:1990403]; neuron differentiation [GO:0030182]; positive regulation of cell cycle arrest [GO:0071158]; positive regulation of glial cell differentiation [GO:0045687]; positive regulation of neuron differentiation [GO:0045666]; protein autoubiquitination [GO:0051865]; response to hydroperoxide [GO:0033194]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9ULX5-1; Sequence=Displayed; Name=2; IsoId=Q9ULX5-2; Sequence=VSP_042377; 

location:
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q96DY5}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q96DY5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasm {ECO:0000250|UniProtKB:Q96DY5}. Nucleus {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, Nuclear body {ECO:0000250|UniProtKB:Q96DY5}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q96DY5}. Endosome {ECO:0000250|UniProtKB:Q96DY5}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q96DY5}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250|UniProtKB:Q96DY5}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm. Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus. Recruited to nuclear bodies via its interaction with ZBTB16. Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas. {ECO:0000250|UniProtKB:Q96DY5}.


uniprotID: Q9Y508
geneSymbol: RNF114
reactome: R-HSA-983168;
length: 228
go: ENSG00000124226;
name:
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)

sequence:

opentargets:
cytosol [GO:0005829]; intracellular [GO:0005622]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; cell differentiation [GO:0030154]; multicellular organism development [GO:0007275]; protein polyubiquitination [GO:0000209]; spermatogenesis [GO:0007283]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y508-1; Sequence=Displayed; Name=2; IsoId=Q9Y508-2; Sequence=VSP_036843, VSP_036844; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23645206}. Nucleus {ECO:0000269|PubMed:23645206}.


uniprotID: Q8WVZ7
geneSymbol: RNF133
length: 376
go: ENSG00000188050;
name:
E3 ubiquitin-protein ligase RNF133 (EC 2.3.2.27) (RING finger protein 133) (RING-type E3 ubiquitin transferase RNF133)

sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; protein autoubiquitination [GO:0051865]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14B02}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q14B02}.


uniprotID: Q8WVD3
geneSymbol: RNF138
reactome: R-HSA-983168;
length: 245
go: ENSG00000134758;
snps: rs7229690
name:
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)

sequence:

opentargets:
nucleus [GO:0005634]; site of double-strand break [GO:0035861]; metal ion binding [GO:0046872]; protein kinase binding [GO:0019901]; single-stranded DNA binding [GO:0003697]; ubiquitin protein ligase activity [GO:0061630]; cellular response to leukemia inhibitory factor [GO:1990830]; DNA double-strand break processing involved in repair via single-strand annealing [GO:0010792]; double-strand break repair via homologous recombination [GO:0000724]; protein ubiquitination [GO:0016567]; Wnt signaling pathway [GO:0016055]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WVD3-1; Sequence=Displayed; Name=2; IsoId=Q8WVD3-2; Sequence=VSP_021732; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}. Note=Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). {ECO:0000269|PubMed:26502055, ECO:0000269|PubMed:26502057}.


uniprotID: Q8N7C7
geneSymbol: RNF148
name: RING finger protein 148
length: 305
go: ENSG00000235631;
snps: rs7790381
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:

opentargets:
integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q8NC42
geneSymbol: RNF149
length: 400
go: ENSG00000163162;
snps: rs763258401 rs11123868 rs17856945 rs13151
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
name:
E3 ubiquitin-protein ligase RNF149 (EC 2.3.2.27) (DNA polymerase-transactivated protein 2) (RING finger protein 149) (RING-type E3 ubiquitin transferase RNF149)

sequence:

opentargets:
integral component of membrane [GO:0016021]; membrane [GO:0016020]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; cellular response to drug [GO:0035690]; negative regulation of MAPK cascade [GO:0043409]; regulation of protein stability [GO:0031647]; ubiquitin-dependent protein catabolic process [GO:0006511]


uniprotID: Q8N8N0
geneSymbol: RNF152
reactome: R-HSA-8866654;
length: 203
go: ENSG00000176641;
name:
E3 ubiquitin-protein ligase RNF152 (EC 2.3.2.27) (RING finger protein 152) (RING-type E3 ubiquitin transferase RNF152)

sequence:

opentargets:
integral component of organelle membrane [GO:0031301]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; metal ion binding [GO:0046872]; small GTPase binding [GO:0031267]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; apoptotic process [GO:0006915]; cellular response to amino acid starvation [GO:0034198]; negative regulation of TORC1 signaling [GO:1904262]; positive regulation of autophagy [GO:0010508]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]

location:
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25936802, ECO:0000305|PubMed:21203937}; Single-pass membrane protein {ECO:0000269|PubMed:25936802, ECO:0000305|PubMed:21203937}.


uniprotID: Q96PX1
geneSymbol: RNF157
length: 679
go: ENSG00000141576;
opentargets: cytoplasm [GO:0005737]; metal ion binding [GO:0046872]; transferase activity [GO:0016740]
snps: rs2289602 rs11539879 rs59053255
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:M0R5D6}.
name:
E3 ubiquitin ligase RNF157 (EC 2.3.2.27) (RING finger protein 157) (RING-type E3 ubiquitin transferase RNF157)

sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96PX1-1; Sequence=Displayed; Name=2; IsoId=Q96PX1-2; Sequence=VSP_021735; Note=No experimental confirmation available.; 


uniprotID: Q6ZSG1
geneSymbol: RNF165
pdb: 5D0I;5D0K;5D0M;5ULH;5ULK;
name: E3 ubiquitin-protein ligase RNF165 (EC 2.3.2.27) (RING finger protein 165)
length: 346
go: ENSG00000141622;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:E9QAU8}.
sequence:

opentargets:
nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ubiquitin protein ligase activity [GO:0061630]; zinc ion binding [GO:0008270]; forelimb morphogenesis [GO:0035136]; innervation [GO:0060384]; motor neuron axon guidance [GO:0008045]; multicellular organism aging [GO:0010259]; muscle structure development [GO:0061061]; positive regulation of BMP signaling pathway [GO:0030513]; protein catabolic process [GO:0030163]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6ZSG1-1; Sequence=Displayed; Name=2; IsoId=Q6ZSG1-2; Sequence=VSP_045128; 


uniprotID: Q9H6Y7
geneSymbol: RNF167
length: 350
go: ENSG00000108523;
snps: rs1127356
name:
E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167) (RING-type E3 ubiquitin transferase RNF167) (RING105)

sequence:

opentargets:
cytoplasm [GO:0005737]; endomembrane system [GO:0012505]; integral component of membrane [GO:0016021]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; negative regulation of cell cycle [GO:0045786]; protein polyubiquitination [GO:0000209]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:16314844}; Single-pass membrane protein {ECO:0000269|PubMed:16314844}. Note=Targeted to cytoplasmic membranes.


uniprotID: Q8IYW5
geneSymbol: RNF168
reactome: R-HSA-3108214;R-HSA-5693565;R-HSA-5693571;R-HSA-5693607;R-HSA-69473;
pdb: 3L11;4GB0;5XIS;5XIT;5XIU;5YDK;
length: 571
go: ENSG00000163961;
snps: rs35774921 rs3796129 rs6790173
name:
E3 ubiquitin-protein ligase RNF168 (hRNF168) (EC 2.3.2.27) (RING finger protein 168) (RING-type E3 ubiquitin transferase RNF168)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; K63-linked polyubiquitin modification-dependent protein binding [GO:0070530]; metal ion binding [GO:0046872]; nucleosome binding [GO:0031491]; ubiquitin binding [GO:0043130]; ubiquitin-protein transferase activity [GO:0004842]; cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone H2A K63-linked ubiquitination [GO:0070535]; histone H2A monoubiquitination [GO:0035518]; histone H2A-K13 ubiquitination [GO:0036351]; histone H2A-K15 ubiquitination [GO:0036352]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein K63-linked ubiquitination [GO:0070534]; protein ubiquitination [GO:0016567]; response to ionizing radiation [GO:0010212]; ubiquitin-dependent protein catabolic process [GO:0006511]

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03066, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:19500350, ECO:0000269|PubMed:21041483, ECO:0000269|PubMed:22742833}. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage. {ECO:0000255|HAMAP-Rule:MF_03066}.


uniprotID: Q86T96
geneSymbol: RNF180
length: 592
go: ENSG00000164197;
name:
E3 ubiquitin-protein ligase RNF180 (EC 2.3.2.27) (RING finger protein 180) (RING-type E3 ubiquitin transferase RNF180)

sequence:

opentargets:
integral component of membrane [GO:0016021]; intrinsic component of endoplasmic reticulum membrane [GO:0031227]; nuclear envelope [GO:0005635]; metal ion binding [GO:0046872]; ubiquitin conjugating enzyme binding [GO:0031624]; ubiquitin protein ligase activity [GO:0061630]; adult behavior [GO:0030534]; norepinephrine metabolic process [GO:0042415]; positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436]; positive regulation of protein ubiquitination [GO:0031398]; protein polyubiquitination [GO:0000209]; regulation of catalytic activity [GO:0050790]; serotonin metabolic process [GO:0042428]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86T96-1; Sequence=Displayed; Name=2; IsoId=Q86T96-2; Sequence=VSP_021739, VSP_021740; Name=3; IsoId=Q86T96-3; Sequence=VSP_021738, VSP_021739, VSP_021740; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope {ECO:0000250|UniProtKB:Q3U827}.


uniprotID: Q96D59
geneSymbol: RNF183
name: E3 ubiquitin-protein ligase RNF183 (EC 2.3.2.27)
length: 192
go: ENSG00000165188;
snps: rs3750533 rs3750534
sequence:
MAEQQGRELEAECPVCWNPFNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRRLLCPLCRQPTVLASGQPVTDLPTDTAMLALLRLEPHHVILEGHQLCLKDQPKSRYFLRQPQVYTLDLGPQPGGQTGPPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLMAVILSVTLLLIFSIFWTKQFLWGVG

opentargets:
cis-Golgi network membrane [GO:0033106]; endoplasmic reticulum [GO:0005783]; integral component of endoplasmic reticulum membrane [GO:0030176]; lysosomal membrane [GO:0005765]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [GO:1902237]; protein autoubiquitination [GO:0051865]; protein polyubiquitination [GO:0000209]; response to endoplasmic reticulum stress [GO:0034976]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29507230}; Single-pass type IV membrane protein {ECO:0000305|PubMed:29507230}. Endoplasmic reticulum {ECO:0000269|PubMed:26567849}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8QZS5}. Lysosome membrane {ECO:0000250|UniProtKB:Q8QZS5}.


uniprotID: Q9NXI6
geneSymbol: RNF186
name: E3 ubiquitin-protein ligase RNF186 (EC 2.3.2.27) (RING finger protein 186)
length: 227
go: ENSG00000178828;
snps: rs1541185 rs35541730
sequence:

opentargets:
endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [GO:0070059]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K29-linked ubiquitination [GO:0035519]; protein K63-linked ubiquitination [GO:0070534]; protein localization to mitochondrion [GO:0070585]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23896122}; Multi-pass membrane protein {ECO:0000255}.


uniprotID: Q5TA31
geneSymbol: RNF187
length: 235
go: ENSG00000168159;
name:
E3 ubiquitin-protein ligase RNF187 (EC 2.3.2.27) (RING domain AP1 coactivator 1) (RACO-1) (RING finger protein 187) (RING-type E3 ubiquitin transferase RNF187)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; positive regulation of cell proliferation [GO:0008284]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20852630}. Nucleus {ECO:0000269|PubMed:20852630}. Note=Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.


uniprotID: Q6ZRF8
geneSymbol: RNF207
name: RING finger protein 207
length: 634
go: ENSG00000158286;
snps: rs12073329 rs55823245 rs709209 rs846111
sequence:

opentargets:
perinuclear region of cytoplasm [GO:0048471]; chaperone binding [GO:0051087]; Hsp70 protein binding [GO:0030544]; ion channel binding [GO:0044325]; zinc ion binding [GO:0008270]; cell-cell signaling involved in cardiac conduction [GO:0086019]; positive regulation of delayed rectifier potassium channel activity [GO:1902261]; positive regulation of gene expression [GO:0010628]; positive regulation of voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [GO:1903954]; positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [GO:1903762]; regulation of cardiac muscle contraction [GO:0055117]; regulation of heart looping [GO:1901207]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q6ZRF8-1; Sequence=Displayed; Name=2; IsoId=Q6ZRF8-2; Sequence=VSP_027863, VSP_027864; Name=3; IsoId=Q6ZRF8-3; Sequence=VSP_028439, VSP_028440, VSP_028441; Note=No experimental confirmation available.; Name=4; IsoId=Q6ZRF8-4; Sequence=VSP_028439, VSP_028442, VSP_028443; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25281747}. Note=Probably located in the endoplasmic reticulum and/or possibly the cis-Golgi apparatus. {ECO:0000269|PubMed:25281747}.


uniprotID: Q9H0X6
geneSymbol: RNF208
name: RING finger protein 208
length: 261
go: ENSG00000212864;
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; protein autoubiquitination [GO:0051865]


uniprotID: P34096
geneSymbol: RNASE4
pdb: 1RNF;2RNF;
name: Ribonuclease 4 (RNase 4) (EC 3.1.27.-)
length: 147
go: ENSG00000258818;
drug: DB03448;
snps: rs3748338
location: SUBCELLULAR LOCATION: Secreted.
sequence:
MALQRTHSLLLLLLLTLLGLGLVQPSYGQDGMYQRFLRQHVHPEETGGSDRYCNLMMQRRKMTLYHCKRFNTFIHEDIWNIRSICSTTNIQCKNGKMNCHEGVVKVTDCRDTGSSRAPNCRYRAIASTRRVVIACEGNPQVPVHFDG

opentargets:
extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; ribonuclease A activity [GO:0004522]; ribonuclease activity [GO:0004540]; mRNA cleavage [GO:0006379]


uniprotID: Q93091
geneSymbol: RNASE6
reactome: R-HSA-6803157;
pdb: 4X09;5OAB;
name: Ribonuclease K6 (RNase K6) (EC 3.1.27.-)
length: 150
go: ENSG00000169413;
snps: rs1045922
sequence:
MVLCFPLLLLLLVLWGPVCPLHAWPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL

opentargets:
cytoplasmic vesicle [GO:0031410]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; intracellular [GO:0005622]; lysosome [GO:0005764]; endonuclease activity [GO:0004519]; nucleic acid binding [GO:0003676]; ribonuclease activity [GO:0004540]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; antimicrobial humoral response [GO:0019730]; defense response [GO:0006952]; defense response to Gram-negative bacterium [GO:0050829]; defense response to Gram-positive bacterium [GO:0050830]; defense response to virus [GO:0051607]; innate immune response [GO:0045087]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis [GO:0090501]

location:
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25075772}. Lysosome {ECO:0000305|PubMed:25075772}. Cytoplasmic granule {ECO:0000269|PubMed:25075772}.


uniprotID: P60153
geneSymbol: RNASE9
name: Inactive ribonuclease-like protein 9
length: 205
go: ENSG00000188655;
snps: rs12590446 rs1243647
location: SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
sequence:

opentargets:
extracellular region [GO:0005576]; nucleic acid binding [GO:0003676]; ribonuclease activity [GO:0004540]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=alpha1, alpha2, alpha12, beta2, beta12; IsoId=P60153-1; Sequence=Displayed; Name=2; Synonyms=alpha23, alpha123; IsoId=P60153-2; Sequence=VSP_041856; 


uniprotID: Q86VV4
geneSymbol: RANBP3L
name: Ran-binding protein 3-like
length: 465
go: ENSG00000164188;
snps: rs1035480 rs35433829 rs16902872
sequence:

opentargets:
centrosome [GO:0005813]; cytoplasm [GO:0005737]; nuclear pore [GO:0005643]; nucleus [GO:0005634]; Ran GTPase binding [GO:0008536]; SMAD binding [GO:0046332]; mesenchymal cell differentiation involved in bone development [GO:1901706]; negative regulation of osteoblast differentiation [GO:0045668]; positive regulation of GTPase activity [GO:0043547]; positive regulation of myoblast differentiation [GO:0045663]; protein export from nucleus [GO:0006611]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q86VV4-1; Sequence=Displayed; Name=2; IsoId=Q86VV4-2; Sequence=VSP_029893, VSP_029894; Note=No experimental confirmation available.; Name=3; IsoId=Q86VV4-3; Sequence=VSP_044463; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:25755279}. Cytoplasm {ECO:0000305|PubMed:25755279}.


uniprotID: O60518
geneSymbol: RANBP6
name: Ran-binding protein 6 (RanBP6)
length: 1105
go: ENSG00000137040;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; nuclear membrane [GO:0031965]; nuclear periphery [GO:0034399]; nuclear localization sequence binding [GO:0008139]; NLS-bearing protein import into nucleus [GO:0006607]; ribosomal protein import into nucleus [GO:0006610]


uniprotID: Q92834
geneSymbol: RPGR
pdb: 4JHN;4JHP;4QAM;
name: X-linked retinitis pigmentosa GTPase regulator
length: 1020
go: ENSG00000156313;
sequence:

opentargets:
centrosome [GO:0005813]; ciliary basal body [GO:0036064]; Golgi apparatus [GO:0005794]; photoreceptor outer segment [GO:0001750]; sperm flagellum [GO:0036126]; guanyl-nucleotide exchange factor activity [GO:0005085]; RNA binding [GO:0003723]; cilium assembly [GO:0060271]; intracellular protein transport [GO:0006886]; intraciliary transport [GO:0042073]; response to stimulus [GO:0050896]; visual perception [GO:0007601]

snps:
rs62638630 rs62638629 rs62638634 rs111631988 rs1801685 rs62638636 rs62638637 rs62638643 rs62638644 rs137852550 rs5963403 rs62650218 rs62638651 rs62650220 rs138018739 rs62642057 rs62640587 rs62640589 rs62640590 rs62640593 rs41305223 rs1801687 rs62635003 rs62635004 rs41312104 rs1801688 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Comment=Additional isoforms seem to exist.; Name=1; IsoId=Q92834-1; Sequence=Displayed; Name=2; IsoId=Q92834-2; Sequence=VSP_005548; Name=3; IsoId=Q92834-3; Sequence=VSP_005548, VSP_005549, VSP_005550; Name=4; IsoId=Q92834-4; Sequence=VSP_005547, VSP_005548; Name=5; IsoId=Q92834-5; Sequence=VSP_009183, VSP_009184; Note=No experimental confirmation available.; Name=6; Synonyms=ORF15; IsoId=Q92834-6; Sequence=VSP_044559; 

location:
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9R0X5}. Golgi apparatus {ECO:0000269|PubMed:15772089}.; SUBCELLULAR LOCATION: Isoform 6: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme.


uniprotID: P49247
geneSymbol: RPIA
reactome: R-HSA-5659996;R-HSA-6791461;R-HSA-71336;
name: Ribose-5-phosphate isomerase (EC 5.3.1.6) (Phosphoriboisomerase)
length: 311
go: ENSG00000153574;
drug: DB01756;
snps: rs121918591
sequence:

opentargets:
cytosol [GO:0005829]; intracellular membrane-bounded organelle [GO:0043231]; identical protein binding [GO:0042802]; monosaccharide binding [GO:0048029]; ribose-5-phosphate isomerase activity [GO:0004751]; D-ribose metabolic process [GO:0006014]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]


uniprotID: P61513
geneSymbol: RPL37A
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L37a (Large ribosomal subunit protein eL43)
sequence: MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ
length: 92
go: ENSG00000197756;
opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q2QD12
geneSymbol: RPEL1
reactome: R-HSA-71336;
length: 228
go: ENSG00000235376;
name:
Ribulose-phosphate 3-epimerase-like protein 1 (EC 5.1.3.1) (Ribulose-5-phosphate-3-epimerase-like protein 1)

sequence:

opentargets:
cytosol [GO:0005829]; metal ion binding [GO:0046872]; ribulose-phosphate 3-epimerase activity [GO:0004750]; cellular carbohydrate metabolic process [GO:0044262]; pentose catabolic process [GO:0019323]; pentose-phosphate shunt [GO:0006098]; pentose-phosphate shunt, non-oxidative branch [GO:0009052]


uniprotID: P47914
geneSymbol: RPL29
pdb: 4UG0;4V6X;5AJ0;5T2C;6EK0;
length: 159
go: ENSG00000162244;
name:
60S ribosomal protein L29 (Cell surface heparin-binding protein HIP) (Large ribosomal subunit protein eL29)

sequence:
MAKSKNHTTHNQSRKWHRNGIKKPRSQRYESLKGVDPKFLRNMRFAKKHNKKGLKKMQANNAKAMSARAEAIKALVKPKEVKPKIPKGVSRKLDRLAYIAHPKLGKRARARIAKGLRLCRPKAKAKAKAKDQTKAQAAAPASVPAQAPKRTQAPTKASE

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; cadherin binding [GO:0045296]; heparin binding [GO:0008201]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; embryo implantation [GO:0007566]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q8TDU9
geneSymbol: RXFP4
reactome: R-HSA-418594;R-HSA-444821;
length: 374
go: ENSG00000173080;
snps: rs2152051
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Relaxin-3 receptor 2 (RLN3 receptor 2) (G-protein coupled receptor 100) (G-protein coupled receptor GPCR142) (Insulin-like peptide INSL5 receptor) (Relaxin family peptide receptor 4)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; galanin receptor activity [GO:0004966]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of feeding behavior [GO:2000253]


uniprotID: P62888
geneSymbol: RPL30
pdb: 3VI6;4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L30 (Large ribosomal subunit protein eL30)
length: 115
go: ENSG00000156482;
sequence:
MVAAKKTKKSLESINSRLQLVMKSGKYVLGYKQTLKMIRQGKAKLVILANNCPALRKSEIEYYAMLAKTGVHHYSGNNIELGTACGKYYRVCTLAIIDPGDSDIIRSMPEQTGEK

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-negative bacterium [GO:0050829]; killing of cells of other organism [GO:0031640]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q92901
geneSymbol: RPL3L
name: 60S ribosomal protein L3-like (Large ribosomal subunit protein uL3-like)
length: 407
go: ENSG00000140986;
snps: rs34265469
sequence:

opentargets:
cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]


uniprotID: A6NKH3
geneSymbol: RPL37AP8
name: Putative 60S ribosomal protein L37a-like protein (Ribosomal protein L37a pseudogene 8)
sequence: MAKCTKKVGGIVSKYRTHHGASLWKMVKEIEISQHTKYTCSFCGKTKMKRRAVKIRHCNSCMKTVAGSAWTYNTTSAVMVKSAIRRLKELKDQ
length: 93
opentargets:
ribosome [GO:0005840]; metal ion binding [GO:0046872]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]


uniprotID: P39023
geneSymbol: RPL3
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
length: 403
go: ENSG00000100316;
drug: DB02494;DB07374;DB04865;DB08437;
name:
60S ribosomal protein L3 (HIV-1 TAR RNA-binding protein B) (TARBP-B) (Large ribosomal subunit protein uL3)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; nucleolus [GO:0005730]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to interleukin-4 [GO:0071353]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit assembly [GO:0000027]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:16963496}. Cytoplasm {ECO:0000269|PubMed:16963496}.


uniprotID: P49207
geneSymbol: RPL34
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L34 (Large ribosomal subunit protein eL34)
length: 117
go: ENSG00000109475;
sequence:
MVQRLTYRRRLSYNTASNKTRLSRTPGNRIVYLYTKKVGKAPKSACGVCPGRLRGVRAVRPKVLMRLSKTKKHVSRAYGGSMCAKCVRDRIKRAFLIEEQKIVVKVLKAQAQSQKAK

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; cadherin binding [GO:0045296]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q29223}. Note=Detected on cytosolic polysomes (PubMed:25957688). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q29223, ECO:0000269|PubMed:25957688}.


uniprotID: Q9NSD7
geneSymbol: RXFP3
reactome: R-HSA-418594;R-HSA-444821;
length: 469
go: ENSG00000182631;
location: SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
name:
Relaxin-3 receptor 1 (RLN3 receptor 1) (G protein-coupled receptor SALPR) (G-protein coupled receptor GPCR135) (Relaxin family peptide receptor 3) (Somatostatin- and angiotensin-like peptide receptor)

sequence:

opentargets:
integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; G protein-coupled peptide receptor activity [GO:0008528]; G protein-coupled receptor activity [GO:0004930]; galanin receptor activity [GO:0004966]; G protein-coupled receptor signaling pathway [GO:0007186]; neuropeptide signaling pathway [GO:0007218]; positive regulation of cytokinesis [GO:0032467]


uniprotID: P62891
geneSymbol: RPL39
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L39 (Large ribosomal subunit protein eL39)
sequence: MSSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL
length: 51
go: ENSG00000198918;
opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular space [GO:0005615]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; antibacterial humoral response [GO:0019731]; antimicrobial humoral immune response mediated by antimicrobial peptide [GO:0061844]; cytoplasmic translation [GO:0002181]; defense response to Gram-positive bacterium [GO:0050830]; innate immune response in mucosa [GO:0002227]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P63173
geneSymbol: RPL38
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L38 (Large ribosomal subunit protein eL38)
sequence: MPRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKEKAEKLKQSLPPGLAVKELK
length: 70
go: ENSG00000172809;
opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; eukaryotic 80S initiation complex [GO:0033291]; focal adhesion [GO:0005925]; polysomal ribosome [GO:0042788]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; 90S preribosome assembly [GO:0034463]; axial mesoderm development [GO:0048318]; cytoplasmic translation [GO:0002181]; middle ear morphogenesis [GO:0042474]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ossification [GO:0001503]; regulation of translation [GO:0006417]; sensory perception of sound [GO:0007605]; skeletal system development [GO:0001501]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P62070
geneSymbol: RRAS2
pdb: 2ERY;
name: Ras-related protein R-Ras2 (Ras-like protein TC21) (Teratocarcinoma oncogene)
length: 204
go: ENSG00000133818;
snps: rs113954997
sequence:

opentargets:
endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; osteoblast differentiation [GO:0001649]; positive regulation of cell migration [GO:0030335]; Ras protein signal transduction [GO:0007265]; regulation of neuron death [GO:1901214]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=P62070-1; Sequence=Displayed; Name=2; IsoId=P62070-2; Sequence=VSP_043066; Note=No experimental confirmation available.; Name=3; IsoId=P62070-3; Sequence=VSP_044485; Note=No experimental confirmation available.; Name=4; IsoId=P62070-4; Sequence=VSP_055842; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).


uniprotID: P78346
geneSymbol: RPP30
reactome: R-HSA-6784531;R-HSA-6791226;
name: Ribonuclease P protein subunit p30 (RNaseP protein p30) (EC 3.1.26.5) (RNase P subunit 2)
length: 268
go: ENSG00000148688;
snps: rs11544145
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
sequence:

opentargets:
multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease MRP complex [GO:0000172]; ribonuclease P activity [GO:0004526]; RNA binding [GO:0003723]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P78346-1; Sequence=Displayed; Name=2; IsoId=P78346-2; Sequence=VSP_045673; Note=No experimental confirmation available. {ECO:0000305}; 


uniprotID: Q9HB90
geneSymbol: RRAGC
reactome: R-HSA-1632852;R-HSA-165159;R-HSA-166208;R-HSA-380972;R-HSA-5628897;R-HSA-8943724;
pdb: 3LLU;6CES;6EHR;
name: Ras-related GTP-binding protein C (Rag C) (RagC) (GTPase-interacting protein 2) (TIB929)
length: 399
go: ENSG00000116954;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; EGO complex [GO:0034448]; Gtr1-Gtr2 GTPase complex [GO:1990131]; intracellular membrane-bounded organelle [GO:0043231]; lysosome [GO:0005764]; nucleus [GO:0005634]; GDP binding [GO:0019003]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; GTPase binding [GO:0051020]; magnesium ion binding [GO:0000287]; protein heterodimerization activity [GO:0046982]; apoptotic process [GO:0006915]; cell cycle arrest [GO:0007050]; cellular protein localization [GO:0034613]; cellular response to amino acid starvation [GO:0034198]; cellular response to amino acid stimulus [GO:0071230]; cellular response to starvation [GO:0009267]; positive regulation of TOR signaling [GO:0032008]; regulation of autophagy [GO:0010506]; regulation of macroautophagy [GO:0016241]; regulation of TOR signaling [GO:0032006]; regulation of TORC1 signaling [GO:1903432]; response to amino acid [GO:0043200]; RNA splicing [GO:0008380]; small GTPase mediated signal transduction [GO:0007264]; transcription, DNA-templated [GO:0006351]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11073942}. Nucleus {ECO:0000269|PubMed:11073942}. Lysosome {ECO:0000269|PubMed:20381137}. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). {ECO:0000269|PubMed:11073942}.


uniprotID: O95059
geneSymbol: RPP14
reactome: R-HSA-6784531;R-HSA-6791226;
name: Ribonuclease P protein subunit p14 (EC 3.1.26.5)
length: 124
go: ENSG00000163684;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:
MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLLISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRELVLD

opentargets:
multimeric ribonuclease P complex [GO:0030681]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease P activity [GO:0004526]; RNA binding [GO:0003723]; tRNA 5'-leader removal [GO:0001682]


uniprotID: Q96P16
geneSymbol: RPRD1A
reactome: R-HSA-6807505;
pdb: 4JXT;4NAC;
length: 312
go: ENSG00000141425;
name:
Regulation of nuclear pre-mRNA domain-containing protein 1A (Cyclin-dependent kinase inhibitor 2B-related protein) (p15INK4B-related protein)

sequence:

opentargets:
nucleoplasm [GO:0005654]; RNA polymerase II, holoenzyme [GO:0016591]; identical protein binding [GO:0042802]; dephosphorylation of RNA polymerase II C-terminal domain [GO:0070940]; snRNA transcription by RNA polymerase II [GO:0042795]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96P16-1; Sequence=Displayed; Name=2; IsoId=Q96P16-3; Sequence=VSP_029531; 


uniprotID: P56182
geneSymbol: RRP1
reactome: R-HSA-6791226;
length: 461
go: ENSG00000160214;
snps: rs34224504 rs915770
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:9192856}.
name:
Ribosomal RNA processing protein 1 homolog A (Novel nuclear protein 1) (NNP-1) (Nucleolar protein Nop52) (RRP1-like protein)

sequence:

opentargets:
nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; preribosome, small subunit precursor [GO:0030688]; RNA binding [GO:0003723]; rRNA processing [GO:0006364]


uniprotID: P32969
geneSymbol: RPL9; RPL9P7; RPL9P8; RPL9P9
pdb: 2CQL;4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L9 (Large ribosomal subunit protein uL6)
length: 192
go: ENSG00000163682;
sequence:
MKTILSNQTVDIPENVDITLKGRTVIVKGPRGTLRRDFNHINVELSLLGKKKKRLRVDKWWGNRKELATVRTICSHVQNMIKGVTLGFRYKMRSVYAHFPINVVIQENGSLVEIRNFLGEKYIRRVRMRPGVACSVSQAQKDELILEGNDIELVSNSAALIQQATTVKNKDIRKFLDGIYVSEKGTVQQADE

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; ribosome [GO:0005840]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q8N4K4
geneSymbol: RPRML
name: Reprimo-like protein
length: 120
go: ENSG00000179673;
opentargets: integral component of membrane [GO:0016021]
location: SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
sequence:
MNATFLNHSGLEEVDGVGGGAGAALGNRTHGLGTWLGCCPGGAPLAASDGVPAGLAPDERSLWVSRVAQIAVLCVLSLTVVFGVFFLGCNLLIKSESMINFLVQERRPSKDVGAAILGLY


uniprotID: Q9NQ39
geneSymbol: RPS10P5
name: Putative 40S ribosomal protein S10-like
length: 176
sequence:
MLMPKKNRIAIHELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGCVKEQFAWRHFYWYLTNEGSQYLRDYLHLPPEIVPATLHLPPEIVPATLHRSRPETGRPRPKGLEGKRPARLTRREADRDTYRRCSVPPGADKKAEAGAGSATEFQFRGRCGRGRGQPPQ

opentargets:
cytosolic small ribosomal subunit [GO:0022627]; structural constituent of ribosome [GO:0003735]; ribosomal small subunit assembly [GO:0000028]


uniprotID: P05386
geneSymbol: RPLP1
pdb: 2LBF;4BEH;4V6X;
name: 60S acidic ribosomal protein P1 (Large ribosomal subunit protein P1)
length: 114
go: ENSG00000137818;
sequence:
MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; protein kinase activator activity [GO:0030295]; ribonucleoprotein complex binding [GO:0043021]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P05386-1; Sequence=Displayed; Name=2; IsoId=P05386-2; Sequence=VSP_045244; Note=No experimental confirmation available.; 


uniprotID: Q9NS64
geneSymbol: RPRM
name: Protein reprimo
length: 109
go: ENSG00000177519;
sequence:
MNPALGNQTDVAGLFLANSSEALERAVRCCTQASVVTDDGFAEGGPDERSLYIMRVVQIAVMCVLSLTVVFGIFFLGCNLLIKSEGMINFLVKDRRPSKEVEAVVVGPY

opentargets:
cytoplasm [GO:0005737]; integral component of membrane [GO:0016021]; cell cycle arrest [GO:0007050]; regulation of mitotic cell cycle [GO:0007346]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.


uniprotID: Q6P1L8
geneSymbol: MRPL14
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 145
go: ENSG00000180992;
name:
39S ribosomal protein L14, mitochondrial (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) (Mitochondrial large ribosomal subunit protein uL14m)

sequence:
MAFFTGLWGPFTCVSRVLSHHCFSTTGSLSAIQKMTRVRVVDNSALGNSPYHRAPRCIHVYKKNGVGKVGDQILLAIKGQKKKALIVGHCMPGPRMTPRFDSNNVVLIEDNGNPVGTRIKTPIPTSLRKREGEYSKVLAIAQNFV

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11543634, ECO:0000269|PubMed:22829778, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: Q15050
geneSymbol: RRS1
name: Ribosome biogenesis regulatory protein homolog
length: 365
go: ENSG00000179041;
snps: rs34077648 rs3739335 rs3739336
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|Ref.3}.
sequence:

opentargets:
condensed nuclear chromosome [GO:0000794]; endoplasmic reticulum [GO:0005783]; fibrillar center [GO:0001650]; nucleolus [GO:0005730]; nucleus [GO:0005634]; preribosome, large subunit precursor [GO:0030687]; 5S rRNA binding [GO:0008097]; RNA binding [GO:0003723]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; hematopoietic progenitor cell differentiation [GO:0002244]; mitotic metaphase plate congression [GO:0007080]; protein localization to nucleolus [GO:1902570]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; ribosomal large subunit export from nucleus [GO:0000055]


uniprotID: Q9BYD1
geneSymbol: MRPL13
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 178
go: ENSG00000172172;
name:
39S ribosomal protein L13, mitochondrial (L13mt) (MRP-L13) (Mitochondrial large ribosomal subunit protein uL13m)

sequence:
MSSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHKPVYHALSDCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPVAIVKLAIYGMLPKNLHRRTMMERLHLFPDEYIPEDILKNLVEELPQPRKIPKRLDEYTQEEIDAFPRLWTPPEDYRL

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; ribosome [GO:0005840]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; negative regulation of translation [GO:0017148]; translation [GO:0006412]


uniprotID: O60930
geneSymbol: RNASEH1
pdb: 2QK9;2QKB;2QKK;3BSU;
name: Ribonuclease H1 (RNase H1) (EC 3.1.26.4) (Ribonuclease H type II)
length: 286
go: ENSG00000171865;
snps: rs1136545 rs766294940 rs1057517675
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:

opentargets:
cytoplasm [GO:0005737]; magnesium ion binding [GO:0000287]; nucleic acid binding [GO:0003676]; ribonuclease activity [GO:0004540]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication, removal of RNA primer [GO:0043137]; RNA catabolic process [GO:0006401]; RNA phosphodiester bond hydrolysis, endonucleolytic [GO:0090502]


uniprotID: Q9NX20
geneSymbol: MRPL16
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 251
go: ENSG00000166902;
snps: rs7122468 rs12787462 rs491671
name:
39S ribosomal protein L16, mitochondrial (L16mt) (MRP-L16) (Mitochondrial large ribosomal subunit protein uL16m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: O75818
geneSymbol: RPP40
reactome: R-HSA-6784531;R-HSA-6791226;
name: Ribonuclease P protein subunit p40 (RNaseP protein p40) (EC 3.1.26.5) (RNase P subunit 1)
length: 363
go: ENSG00000124787;
snps: rs12332997
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000305}.
sequence:

opentargets:
nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ribonuclease P activity [GO:0004526]; tRNA processing [GO:0008033]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O75818-1; Sequence=Displayed; Name=2; IsoId=O75818-2; Sequence=VSP_037346; Note=No experimental confirmation available.; 


uniprotID: P62249
geneSymbol: RPS16
pdb: 4UG0;4V6X;5A2Q;5AJ0;5FLX;5LKS;5OA3;5T2C;5VYC;6EK0;6FEC;6G18;6G4S;6G4W;6G51;6G53;6G5H;6G5I;
name: 40S ribosomal protein S16 (Small ribosomal subunit protein uS9)
length: 146
go: ENSG00000105193;
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-6791226;R-HSA-72649;R-HSA-72689;R-HSA-72695;R-HSA-72702;R-HSA-72706;R-HSA-72764;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

sequence:
MPSKGPLQSVQVFGRKKTATAVAHCKRGNGLIKVNGRPLEMIEPRTLQYKLLEPVLLLGKERFAGVDIRVRVKGGGHVAQIYAIRQSISKALVAYYQKYVDEASKKEIKDILIQYDRTLLVADPRRCESKKFGGPGARARYQKSYR

opentargets:
cytosol [GO:0005829]; cytosolic small ribosomal subunit [GO:0022627]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleoplasm [GO:0005654]; small ribosomal subunit [GO:0015935]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to leukemia inhibitory factor [GO:1990830]; liver regeneration [GO:0097421]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P05388
geneSymbol: RPLP0
pdb: 4V6W;4V6X;5AJ0;
name: 60S acidic ribosomal protein P0 (60S ribosomal protein L10E) (Large ribosomal subunit protein uL10)
length: 317
go: ENSG00000089157;
reactome:
R-HSA-156827;R-HSA-156902;R-HSA-1799339;R-HSA-192823;R-HSA-2408557;R-HSA-6791226;R-HSA-72689;R-HSA-72706;R-HSA-72764;R-HSA-8950505;R-HSA-9010553;R-HSA-975956;R-HSA-975957;

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic ribonucleoprotein granule [GO:0036464]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleus [GO:0005634]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; ribonucleoprotein complex [GO:1990904]; large ribosomal subunit rRNA binding [GO:0070180]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; interleukin-12-mediated signaling pathway [GO:0035722]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit assembly [GO:0000027]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P05388-1; Sequence=Displayed; Name=2; IsoId=P05388-2; Sequence=VSP_055867; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19188445}. Cytoplasm {ECO:0000269|PubMed:19188445}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19188445}.


uniprotID: Q9Y3B7
geneSymbol: MRPL11
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 192
go: ENSG00000174547;
name:
39S ribosomal protein L11, mitochondrial (L11mt) (MRP-L11) (Mitochondrial large ribosomal subunit protein uL11m)

sequence:
MSKLGRAARGLRKPEVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGARQTGKEVAGLVTLKHVYEIARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVKDLSSEELAAFQKERAIFLAAQKEADLAAQEEAAKK

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9Y3B7-1; Sequence=Displayed; Name=2; IsoId=Q9Y3B7-2; Sequence=VSP_041077; Name=3; IsoId=Q9Y3B7-3; Sequence=VSP_045237; Note=No experimental confirmation available. {ECO:0000305}; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: P05387
geneSymbol: RPLP2
pdb: 1S4J;2JDL;2LBF;2W1O;4BEH;4V6X;5DDZ;5GU4;
length: 115
go: ENSG00000177600;
name:
60S acidic ribosomal protein P2 (Large ribosomal subunit protein P2) (Renal carcinoma antigen NY-REN-44)

sequence:
MRYVASYLLAALGGNSSPSAKDIKKILDSVGIEADDDRLNKVISELNGKNIEDVIAQGIGKLASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEKKEESEESDDDMGFGLFD

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; synapse [GO:0045202]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational elongation [GO:0006414]; translational initiation [GO:0006413]


uniprotID: Q9H2S5
geneSymbol: RNF39
name: RING finger protein 39 (Protein HZFw)
length: 420
go: ENSG00000204618;
opentargets: cytoplasm [GO:0005737]; metal ion binding [GO:0046872]
snps: rs2074479 rs2301752 rs1057539 rs2301753
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; Synonyms=HZFW1; IsoId=Q9H2S5-1; Sequence=Displayed; Name=2; Synonyms=HZFW2; IsoId=Q9H2S5-2; Sequence=VSP_014242; Name=3; Synonyms=HZFW3; IsoId=Q9H2S5-3; Sequence=VSP_014240, VSP_014241; 


uniprotID: P04843
geneSymbol: RPN1
reactome: R-HSA-1799339;R-HSA-446203;
length: 607
go: ENSG00000163902;
name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1)

sequence:

opentargets:
cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; integral component of membrane [GO:0016021]; melanosome [GO:0042470]; membrane [GO:0016020]; oligosaccharyltransferase complex [GO:0008250]; rough endoplasmic reticulum [GO:0005791]; dolichyl-diphosphooligosaccharide-protein glycotransferase activity [GO:0004579]; RNA binding [GO:0003723]; cellular protein modification process [GO:0006464]; protein N-linked glycosylation via asparagine [GO:0018279]

location:
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:E2RQ08, ECO:0000250|UniProtKB:Q9GMB0}. Endoplasmic reticulum membrane; Single-pass type I membrane protein {ECO:0000305}. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.


uniprotID: Q8TDP1
geneSymbol: RNASEH2C
pdb: 3P56;3PUF;
length: 164
go: ENSG00000172922;
opentargets: nucleus [GO:0005634]; ribonuclease H2 complex [GO:0032299]; RNA catabolic process [GO:0006401]
snps: rs75328625 rs773527127 rs78635798 rs76091978 rs75146158 rs78464826
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Ribonuclease H2 subunit C (RNase H2 subunit C) (Aicardi-Goutieres syndrome 3 protein) (AGS3) (RNase H1 small subunit) (Ribonuclease HI subunit C)

sequence:
MESGDEAAIERHRVHLRSATLRDAVPATLHLLPCEVAVDGPAPVGRFFTPAIRQGPEGLEVSFRGRCLRGEEVAVPPGLVGYVMVTEEKKVSMGKPDPLRDSGTDDQEEEPLERDFDRFIGATANFSRFTLWGLETIPGPDAKVRGALTWPSLAAAIHAQVPED


uniprotID: P83881
geneSymbol: RPL36A
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
length: 106
go: ENSG00000241343;
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
60S ribosomal protein L36a (60S ribosomal protein L44) (Cell growth-inhibiting gene 15 protein) (Cell migration-inducing gene 6 protein) (Large ribosomal subunit protein eL42)

sequence:
MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; polysomal ribosome [GO:0042788]; ribosome [GO:0005840]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P42766
geneSymbol: RPL35
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L35 (Large ribosomal subunit protein uL29)
length: 123
go: ENSG00000136942;
sequence:
MAKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRKSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEENLKTKKQQRKERLYPLRKYAVKA

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; nucleolus [GO:0005730]; mRNA binding [GO:0003729]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q13129
geneSymbol: RLF
name: Zinc finger protein Rlf (Rearranged L-myc fusion gene protein) (Zn-15-related protein)
length: 1914
go: ENSG00000117000;
snps: rs35189918 rs35563960 rs35042446 rs34123123 rs34141181 rs10889205
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleus [GO:0005634]; DNA binding [GO:0003677]; DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; zinc ion binding [GO:0008270]; chromosome organization [GO:0051276]; DNA integration [GO:0015074]; histone H3-K4 monomethylation [GO:0097692]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; regulation of DNA methylation [GO:0044030]; regulation of transcription, DNA-templated [GO:0006355]


uniprotID: O76064
geneSymbol: RNF8
reactome: R-HSA-5693565;R-HSA-5693571;R-HSA-5693607;R-HSA-69473;
pdb: 2CSW;2PIE;4AYC;4ORH;4WHV;
length: 485
go: ENSG00000112130;
snps: rs34338974 rs1139944
name:
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)

sequence:

opentargets:
chromosome, telomeric region [GO:0000781]; cytosol [GO:0005829]; midbody [GO:0030496]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; site of double-strand break [GO:0035861]; ubiquitin ligase complex [GO:0000151]; chromatin binding [GO:0003682]; histone binding [GO:0042393]; identical protein binding [GO:0042802]; protein homodimerization activity [GO:0042803]; ubiquitin binding [GO:0043130]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; cell cycle [GO:0007049]; cell division [GO:0051301]; cellular response to DNA damage stimulus [GO:0006974]; double-strand break repair [GO:0006302]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone exchange [GO:0043486]; histone H2A K63-linked ubiquitination [GO:0070535]; histone H2A ubiquitination [GO:0033522]; histone H2B ubiquitination [GO:0033523]; interstrand cross-link repair [GO:0036297]; isotype switching [GO:0045190]; negative regulation of transcription elongation from RNA polymerase II promoter [GO:0034244]; positive regulation of DNA repair [GO:0045739]; protein autoubiquitination [GO:0051865]; protein K48-linked ubiquitination [GO:0070936]; protein K63-linked ubiquitination [GO:0070534]; response to ionizing radiation [GO:0010212]; spermatid development [GO:0007286]; spermatogenesis, exchange of chromosomal proteins [GO:0035093]; ubiquitin-dependent protein catabolic process [GO:0006511]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O76064-1; Sequence=Displayed; Name=2; IsoId=O76064-2; Sequence=VSP_036671, VSP_037831; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.; Name=3; IsoId=O76064-3; Sequence=VSP_054037, VSP_054038; Note=No experimental confirmation available. Gene prediction based on EST data.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:11322894, ECO:0000269|PubMed:14981089, ECO:0000269|PubMed:16215985, ECO:0000269|PubMed:23233665}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03067}. Midbody {ECO:0000255|HAMAP-Rule:MF_03067}. Chromosome, telomere {ECO:0000255|HAMAP-Rule:MF_03067}. Note=Recruited at uncapped telomeres (By similarity). Following DNA damage, such as double-strand breaks, recruited to the sites of damage (PubMed:18001824, PubMed:18077395, PubMed:22266820, PubMed:23233665). During prophase, concomitant with nuclear envelope breakdown, localizes throughout the cell, with a dotted pattern. In telophase, again in the nucleus and also with a discrete dotted pattern in the cytoplasm. In late telophase and during cytokinesis, localizes in the midbody of the tubulin bridge joining the daughter cells. Does not seem to be associated with condensed chromosomes at any time during the cell cycle. During spermatogenesis, sequestered in the cytoplasm by PIWIL1: RNF8 is released following ubiquitination and degradation of PIWIL1. {ECO:0000255|HAMAP-Rule:MF_03067, ECO:0000269|PubMed:18001824, ECO:0000269|PubMed:18077395, ECO:0000269|PubMed:22266820, ECO:0000269|PubMed:23233665}.


uniprotID: P52815
geneSymbol: MRPL12
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
length: 198
go: ENSG00000262814;
snps: rs11546280
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:8626705}.
name:
39S ribosomal protein L12, mitochondrial (L12mt) (MRP-L12) (5c5-2) (Mitochondrial large ribosomal subunit protein bL12m)

sequence:
MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial transcription [GO:0006390]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; positive regulation of transcription, DNA-templated [GO:0045893]


uniprotID: P78317
geneSymbol: RNF4
reactome: R-HSA-5693607;R-HSA-983168;
pdb: 2EA6;2XEU;4PPE;
length: 190
go: ENSG00000063978;
location: SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
name:
E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (RING-type E3 ubiquitin transferase RNF4) (Small nuclear ring finger protein) (Protein SNURF)

sequence:
MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGDEIVDLTCESLEPVVVDLTHNDSVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSRDRDVYVTTHTPRNARDEGATGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI

opentargets:
cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; PML body [GO:0016605]; androgen receptor binding [GO:0050681]; DNA binding [GO:0003677]; DNA-binding transcription factor activity [GO:0003700]; identical protein binding [GO:0042802]; nucleosome binding [GO:0031491]; SUMO polymer binding [GO:0032184]; transcription coactivator activity [GO:0003713]; transcription factor binding [GO:0008134]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin-protein transferase activity [GO:0004842]; zinc ion binding [GO:0008270]; androgen receptor signaling pathway [GO:0030521]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription, DNA-templated [GO:0045893]; proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161]; protein autoubiquitination [GO:0051865]; protein K11-linked ubiquitination [GO:0070979]; protein K48-linked ubiquitination [GO:0070936]; protein K6-linked ubiquitination [GO:0085020]; protein K63-linked ubiquitination [GO:0070534]; regulation of kinetochore assembly [GO:0090234]; regulation of spindle assembly [GO:0090169]; response to arsenic-containing substance [GO:0046685]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P78317-1; Sequence=Displayed; Name=2; IsoId=P78317-2; Sequence=VSP_045789, VSP_045790; Note=No experimental confirmation available.; 


uniprotID: P62945
geneSymbol: RPL41
pdb: 4UG0;4V6X;5A2Q;5AJ0;5LKS;5OA3;5VYC;6EK0;6G5H;
name: 60S ribosomal protein L41 (HG12) (Large ribosomal subunit protein eL41)
sequence: MRAKWRKKRMRRLKRKRRKMRQRSK
length: 25
go: ENSG00000229117;
opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; polysomal ribosome [GO:0042788]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: O75792
geneSymbol: RNASEH2A
pdb: 3P56;3PUF;
length: 299
go: ENSG00000104889;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
name:
Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A)

sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; ribonuclease H2 complex [GO:0032299]; metal ion binding [GO:0046872]; ribonuclease activity [GO:0004540]; RNA binding [GO:0003723]; RNA-DNA hybrid ribonuclease activity [GO:0004523]; DNA replication [GO:0006260]; DNA replication, removal of RNA primer [GO:0043137]; mismatch repair [GO:0006298]; RNA catabolic process [GO:0006401]

snps:
rs76857106 rs76436818 rs77103971 rs7247284 rs62619782 rs79767407 rs75718910 rs79843600 rs15389 rs770898096 rs75037667 


uniprotID: Q9H0F5
geneSymbol: RNF38
pdb: 1X4J;4V3K;4V3L;
length: 515
go: ENSG00000137075;
snps: rs183475137
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23973461}.
name:
E3 ubiquitin-protein ligase RNF38 (EC 2.3.2.27) (RING finger protein 38) (RING-type E3 ubiquitin transferase RNF38)

sequence:

opentargets:
nucleoplasm [GO:0005654]; nucleus [GO:0005634]; sperm flagellum [GO:0036126]; metal ion binding [GO:0046872]; ubiquitin-protein transferase activity [GO:0004842]; male gonad development [GO:0008584]; protein ubiquitination [GO:0016567]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q9H0F5-1; Sequence=Displayed; Name=2; IsoId=Q9H0F5-2; Sequence=VSP_012243; Note=No experimental confirmation available.; Name=3; IsoId=Q9H0F5-3; Sequence=VSP_037337; Name=4; IsoId=Q9H0F5-4; Sequence=VSP_053846, VSP_053847; Note=No experimental confirmation available.; Name=5; IsoId=Q9H0F5-5; Sequence=VSP_053845; Note=No experimental confirmation available.; 


uniprotID: O94941
geneSymbol: UBOX5
reactome: R-HSA-983168;
length: 541
go: ENSG00000185019;
snps: rs999409 rs34205880
name:
RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)

sequence:

opentargets:
focal adhesion [GO:0005925]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; metal ion binding [GO:0046872]; ubiquitin protein ligase activity [GO:0061630]; ubiquitin protein ligase binding [GO:0031625]; ubiquitin-ubiquitin ligase activity [GO:0034450]; protein polyubiquitination [GO:0000209]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=O94941-1; Sequence=Displayed; Name=2; IsoId=O94941-2; Sequence=VSP_042899; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11274149, ECO:0000269|PubMed:11435423}. Note=Enriched in nuclear bodies. {ECO:0000269|PubMed:11274149}.


uniprotID: P62899
geneSymbol: RPL31
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L31 (Large ribosomal subunit protein eL31)
length: 125
go: ENSG00000071082;
sequence:
MAPAKKGGEKKKGRSAINEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTRLNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNLQTVNVDEN

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=P62899-1; Sequence=Displayed; Name=2; IsoId=P62899-2; Sequence=VSP_042572; Note=No experimental confirmation available.; Name=3; IsoId=P62899-3; Sequence=VSP_043224; Note=No experimental confirmation available.; 


uniprotID: P62910
geneSymbol: RPL32
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L32 (Large ribosomal subunit protein eL32)
length: 135
go: ENSG00000144713;
sequence:
MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P36578
geneSymbol: RPL4
pdb: 4UG0;4V6X;5A8L;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L4 (60S ribosomal protein L1) (Large ribosomal subunit protein uL4)
length: 427
go: ENSG00000174444;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; rough endoplasmic reticulum [GO:0005791]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: P61927
geneSymbol: RPL37
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L37 (G1.16) (Large ribosomal subunit protein eL37)
sequence: MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSAKAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPKRAAVAASSSS
length: 97
go: ENSG00000145592;
drug: DB02494;DB07374;DB08437;DB04602;DB04805;
opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; synapse [GO:0045202]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q6DKI1
geneSymbol: RPL7L1
name: 60S ribosomal protein L7-like 1 (Large ribosomal subunit protein uL30-like 1)
length: 246
sequence:

opentargets:
cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; blastocyst formation [GO:0001825]; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000463]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6DKI1-1; Sequence=Displayed; Name=2; IsoId=Q6DKI1-2; Sequence=VSP_056504; Note=No experimental confirmation available.; 


uniprotID: Q9Y3U8
geneSymbol: RPL36
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L36 (Large ribosomal subunit protein eL36)
length: 105
go: ENSG00000130255;
snps: rs11556110
sequence:
MALRYPMAVGLNKGHKVTKNVSKPRHSRRRGRLTKHTKFVRDMIREVCGFAPYERRAMELLKVSKDKRALKFIKKRVGTHIRAKRKREELSNVLAAMRKAAAKKD

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; membrane [GO:0016020]; nucleolus [GO:0005730]; polysomal ribosome [GO:0042788]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:25957688}. Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680}. Note=Detected on cytosolic polysomes (PubMed:25957688). {ECO:0000250|UniProtKB:Q2YGT9, ECO:0000269|PubMed:25957688}.


uniprotID: P18077
geneSymbol: RPL35A
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
length: 110
go: ENSG00000182899;
snps: rs116840808
name:
60S ribosomal protein L35a (Cell growth-inhibiting gene 33 protein) (Large ribosomal subunit protein eL33)

sequence:
MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; extracellular exosome [GO:0070062]; membrane [GO:0016020]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; tRNA binding [GO:0000049]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q969Q0
geneSymbol: RPL36AL
name: 60S ribosomal protein L36a-like (Large ribosomal subunit protein eL42-like)
length: 106
go: ENSG00000165502;
snps: rs3088024
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
sequence:
MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGRRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKGQVIQF

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; structural constituent of ribosome [GO:0003735]; translation [GO:0006412]


uniprotID: P46777
geneSymbol: RPL5
pdb: 4UG0;4V6X;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L5 (Large ribosomal subunit protein uL18)
length: 297
go: ENSG00000122406;
snps: rs121434406 rs11540832
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; membrane [GO:0016020]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; protein-containing complex [GO:0032991]; ribonucleoprotein complex [GO:1990904]; 5S rRNA binding [GO:0008097]; mRNA 3'-UTR binding [GO:0003730]; mRNA 5'-UTR binding [GO:0048027]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; ubiquitin ligase inhibitor activity [GO:1990948]; ubiquitin protein ligase binding [GO:0031625]; negative regulation of protein neddylation [GO:2000435]; negative regulation of ubiquitin protein ligase activity [GO:1904667]; negative regulation of ubiquitin-dependent protein catabolic process [GO:2000059]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; positive regulation of gene expression [GO:0010628]; positive regulation of translation [GO:0045727]; protein stabilization [GO:0050821]; regulation of signal transduction by p53 class mediator [GO:1901796]; ribosomal large subunit assembly [GO:0000027]; ribosomal large subunit biogenesis [GO:0042273]; rRNA processing [GO:0006364]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15469983, ECO:0000269|Ref.7}. Nucleus, nucleolus {ECO:0000269|PubMed:15469983, ECO:0000269|Ref.7}.


uniprotID: P62987
geneSymbol: UBA52
length: 128
go: ENSG00000221983;
reactome:
R-HSA-110312;R-HSA-110314;R-HSA-110320;R-HSA-1169091;R-HSA-1169408;R-HSA-1234176;R-HSA-1236382;R-HSA-1236974;R-HSA-1253288;R-HSA-1295596;R-HSA-1358803;R-HSA-156827;R-HSA-156902;R-HSA-162588;R-HSA-168638;R-HSA-168927;R-HSA-168928;R-HSA-174048;R-HSA-174084;R-HSA-174113;R-HSA-174154;R-HSA-174178;R-HSA-174184;R-HSA-174490;R-HSA-175474;R-HSA-179409;R-HSA-1799339;R-HSA-180534;R-HSA-180585;R-HSA-182971;R-HSA-187577;R-HSA-192823;R-HSA-195253;R-HSA-201681;R-HSA-202424;R-HSA-205043;R-HSA-209543;R-HSA-209560;R-HSA-211733;R-HSA-2122947;R-HSA-2122948;R-HSA-2173788;R-HSA-2173791;R-HSA-2173795;R-HSA-2173796;R-HSA-2408557;R-HSA-2467813;R-HSA-2559580;R-HSA-2559582;R-HSA-2559585;R-HSA-2565942;R-HSA-2644606;R-HSA-2672351;R-HSA-2691232;R-HSA-2871837;R-HSA-2894862;R-HSA-2979096;R-HSA-3134975;R-HSA-3322077;R-HSA-349425;R-HSA-3769402;R-HSA-3785653;R-HSA-382556;R-HSA-400253;R-HSA-445989;R-HSA-450302;R-HSA-450321;R-HSA-450408;R-HSA-4608870;R-HSA-4641257;R-HSA-4641258;R-HSA-4641263;R-HSA-5205685;R-HSA-532668;R-HSA-5357905;R-HSA-5357956;R-HSA-5358346;R-HSA-5362768;R-HSA-5607761;R-HSA-5607764;R-HSA-5610780;R-HSA-5610783;R-HSA-5610785;R-HSA-5632684;R-HSA-5654726;R-HSA-5654727;R-HSA-5654732;R-HSA-5654733;R-HSA-5655862;R-HSA-5656121;R-HSA-5656169;R-HSA-5658442;R-HSA-5668541;R-HSA-5675221;R-HSA-5675482;R-HSA-5676590;R-HSA-5678895;R-HSA-5684264;R-HSA-5685942;R-HSA-5687128;R-HSA-5689603;R-HSA-5689877;R-HSA-5689880;R-HSA-5689896;R-HSA-5689901;R-HSA-5693565;R-HSA-5693607;R-HSA-5696394;R-HSA-5696395;R-HSA-5696397;R-HSA-5696400;R-HSA-6781823;R-HSA-6781827;R-HSA-6782135;R-HSA-6782210;R-HSA-6783310;R-HSA-6791226;R-HSA-6804756;R-HSA-6804757;R-HSA-6804760;R-HSA-6807004;R-HSA-68827;R-HSA-68949;R-HSA-69017;R-HSA-69229;R-HSA-69231;R-HSA-69481;R-HSA-69541;R-HSA-69601;R-HSA-72689;R-HSA-72706;R-HSA-72764;R-HSA-8849469;R-HSA-8852276;R-HSA-8854050;R-HSA-8856825;R-HSA-8856828;R-HSA-8863795;R-HSA-8866652;R-HSA-8866654;R-HSA-8875360;R-HSA-8876493;R-HSA-8939236;R-HSA-8939902;R-HSA-8941858;R-HSA-8948747;R-HSA-8948751;R-HSA-8951664;R-HSA-901032;R-HSA-9010553;R-HSA-9013507;R-HSA-9013973;R-HSA-9014325;R-HSA-9020702;R-HSA-9033241;R-HSA-912631;R-HSA-917729;R-HSA-917937;R-HSA-936440;R-HSA-936964;R-HSA-937039;R-HSA-937041;R-HSA-937042;R-HSA-937072;R-HSA-9604323;R-HSA-975110;R-HSA-975144;R-HSA-975163;R-HSA-975956;R-HSA-975957;R-HSA-977225;R-HSA-983168;

pdb:
2LJ5;2MBH;2MJB;2MUR;2N3U;2N3V;2N3W;2NBD;2NBE;2RSU;4HJK;4JIO;4P4H;4PIG;4PIH;4PIJ;4RF0;4RF1;4S1Z;4UG0;4V6X;4XKL;5AJ0;5GO7;5GO8;5GOB;5GOC;5GOD;5GOG;5GOH;5GOI;5GOJ;5GOK;5HPK;5HPL;5HPS;5HPT;5J26;5J8P;5JBV;5JBY;5LKS;5T2C;6EK0;

name:
Ubiquitin-60S ribosomal protein L40 (CEP52) (Ubiquitin A-52 residue ribosomal protein fusion product 1) [Cleaved into: Ubiquitin; 60S ribosomal protein L40 (Large ribosomal subunit protein eL40)]

sequence:
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLRQLAQKYNCDKMICRKCYARLHPRAVNCRKKKCGHTNNLRPKKKVK

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; cytosolic small ribosomal subunit [GO:0022627]; endocytic vesicle membrane [GO:0030666]; endoplasmic reticulum [GO:0005783]; endoplasmic reticulum membrane [GO:0005789]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]; host cell [GO:0043657]; lysosomal membrane [GO:0005765]; mitochondrial outer membrane [GO:0005741]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; vesicle [GO:0031982]; protein tag [GO:0031386]; structural constituent of ribosome [GO:0003735]; ubiquitin protein ligase binding [GO:0031625]; activation of MAPK activity [GO:0000187]; anaphase-promoting complex-dependent catabolic process [GO:0031145]; cellular protein metabolic process [GO:0044267]; cellular protein modification process [GO:0006464]; cytokine-mediated signaling pathway [GO:0019221]; DNA damage response, detection of DNA damage [GO:0042769]; endosomal transport [GO:0016197]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; global genome nucleotide-excision repair [GO:0070911]; I-kappaB kinase/NF-kappaB signaling [GO:0007249]; interleukin-1-mediated signaling pathway [GO:0070498]; interstrand cross-link repair [GO:0036297]; intracellular transport of virus [GO:0075733]; JNK cascade [GO:0007254]; membrane organization [GO:0061024]; modification-dependent protein catabolic process [GO:0019941]; MyD88-dependent toll-like receptor signaling pathway [GO:0002755]; negative regulation of apoptotic process [GO:0043066]; negative regulation of transcription by RNA polymerase II [GO:0000122]; negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; nucleotide-binding oligomerization domain containing signaling pathway [GO:0070423]; nucleotide-excision repair, DNA damage recognition [GO:0000715]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; nucleotide-excision repair, preincision complex assembly [GO:0006294]; positive regulation of apoptotic process [GO:0043065]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein deubiquitination [GO:0016579]; protein polyubiquitination [GO:0000209]; protein targeting to peroxisome [GO:0006625]; protein ubiquitination [GO:0016567]; regulation of mRNA stability [GO:0043488]; regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061418]; response to insecticide [GO:0017085]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; stress-activated MAPK cascade [GO:0051403]; transcription-coupled nucleotide-excision repair [GO:0006283]; transforming growth factor beta receptor signaling pathway [GO:0007179]; translation [GO:0006412]; translational initiation [GO:0006413]; translesion synthesis [GO:0019985]; transmembrane transport [GO:0055085]; TRIF-dependent toll-like receptor signaling pathway [GO:0035666]; viral life cycle [GO:0019058]; virion assembly [GO:0019068]; Wnt signaling pathway [GO:0016055]

location:
SUBCELLULAR LOCATION: Ubiquitin: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.; SUBCELLULAR LOCATION: 60S ribosomal protein L40: Cytoplasm {ECO:0000250}.


uniprotID: Q9P015
geneSymbol: MRPL15
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 296
go: ENSG00000137547;
name:
39S ribosomal protein L15, mitochondrial (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein uL15m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; cellular response to leukemia inhibitory factor [GO:1990830]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q7L0R7
geneSymbol: RNF44
name: RING finger protein 44
length: 432
go: ENSG00000146083;
opentargets: metal ion binding [GO:0046872]
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7L0R7-1; Sequence=Displayed; Name=2; IsoId=Q7L0R7-2; Sequence=VSP_055432; Note=No experimental confirmation available.; 


uniprotID: Q8NHW5
geneSymbol: RPLP0P6
name: 60S acidic ribosomal protein P0-like (Large ribosomal subunit protein uL10-like)
length: 317
sequence:

opentargets:
cytosolic large ribosomal subunit [GO:0022625]; large ribosomal subunit rRNA binding [GO:0070180]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; ribosomal large subunit assembly [GO:0000027]


uniprotID: Q5VT52
geneSymbol: RPRD2
reactome: R-HSA-6807505;
pdb: 4FLB;
name: Regulation of nuclear pre-mRNA domain-containing protein 2
length: 1461
go: ENSG00000163125;
snps: rs41273537
sequence:

opentargets:
nucleoplasm [GO:0005654]; RNA polymerase II, holoenzyme [GO:0016591]; snRNA transcription by RNA polymerase II [GO:0042795]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; IsoId=Q5VT52-1; Sequence=Displayed; Name=2; IsoId=Q5VT52-2; Sequence=VSP_019546; Note=No experimental confirmation available.; Name=3; IsoId=Q5VT52-3; Sequence=VSP_019547; Name=4; IsoId=Q5VT52-4; Sequence=VSP_035574, VSP_035575; Note=Gene prediction based on EST data.; Name=5; IsoId=Q5VT52-5; Sequence=VSP_019547, VSP_053733, VSP_053734; Note=No experimental confirmation available.; 


uniprotID: P62917
geneSymbol: RPL8
pdb: 4CCM;4CCN;4CCO;4UG0;4V6X;4Y3O;5AJ0;5LKS;5T2C;6EK0;
name: 60S ribosomal protein L8 (Large ribosomal subunit protein uL2)
length: 257
go: ENSG00000161016;
drug: DB02494;DB07374;DB08437;
snps: rs11539893
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000303|PubMed:12962325}.
sequence:

opentargets:
cytosol [GO:0005829]; cytosolic large ribosomal subunit [GO:0022625]; focal adhesion [GO:0005925]; membrane [GO:0016020]; polysomal ribosome [GO:0042788]; postsynapse [GO:0098794]; postsynaptic density [GO:0014069]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; cytoplasmic translation [GO:0002181]; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [GO:0000184]; SRP-dependent cotranslational protein targeting to membrane [GO:0006614]; translation [GO:0006412]; translational initiation [GO:0006413]


uniprotID: Q8N122
geneSymbol: RPTOR
reactome: R-HSA-1632852;R-HSA-165159;R-HSA-166208;R-HSA-3371571;R-HSA-380972;R-HSA-5628897;R-HSA-8943724;
pdb: 5H64;6BCU;6BCX;
name: Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein)
length: 1335
go: ENSG00000141564;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic stress granule [GO:0010494]; cytosol [GO:0005829]; dendrite [GO:0030425]; lysosomal membrane [GO:0005765]; lysosome [GO:0005764]; neuronal cell body [GO:0043025]; nucleoplasm [GO:0005654]; TORC1 complex [GO:0031931]; 14-3-3 protein binding [GO:0071889]; protein binding, bridging [GO:0030674]; protein kinase activator activity [GO:0030295]; protein kinase binding [GO:0019901]; protein serine/threonine kinase inhibitor activity [GO:0030291]; protein-containing complex binding [GO:0044877]; RNA polymerase III type 1 promoter DNA binding [GO:0001030]; RNA polymerase III type 2 promoter DNA binding [GO:0001031]; RNA polymerase III type 3 promoter DNA binding [GO:0001032]; TFIIIC-class transcription factor complex binding [GO:0001156]; cell cycle arrest [GO:0007050]; cellular response to amino acid stimulus [GO:0071230]; cellular response to leucine [GO:0071233]; cellular response to nutrient levels [GO:0031669]; cellular response to starvation [GO:0009267]; positive regulation of cell growth [GO:0030307]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of G1/S transition of mitotic cell cycle [GO:1900087]; positive regulation of peptidyl-serine phosphorylation [GO:0033138]; positive regulation of peptidyl-threonine phosphorylation [GO:0010800]; positive regulation of protein serine/threonine kinase activity [GO:0071902]; positive regulation of TOR signaling [GO:0032008]; positive regulation of transcription by RNA polymerase III [GO:0045945]; regulation of cell growth [GO:0001558]; regulation of cell size [GO:0008361]; regulation of cellular response to heat [GO:1900034]; regulation of macroautophagy [GO:0016241]; TOR signaling [GO:0031929]; TORC1 signaling [GO:0038202]; viral process [GO:0016032]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8N122-1; Sequence=Displayed; Name=2; IsoId=Q8N122-2; Sequence=VSP_010174; Name=3; IsoId=Q8N122-3; Sequence=VSP_054042; 

location:
SUBCELLULAR LOCATION: Cytoplasm. Lysosome. Cytoplasmic granule {ECO:0000269|PubMed:25940091}. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.


uniprotID: Q9H633
geneSymbol: RPP21
reactome: R-HSA-6784531;R-HSA-6791226;
length: 154
go: ENSG00000241370;
snps: rs6986 rs974963
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11497433}.
name:
Ribonuclease P protein subunit p21 (RNaseP protein p21) (EC 3.1.26.5) (Ribonuclease P/MRP 21 kDa subunit) (Ribonucleoprotein V)

sequence:
MAGPVKDREAFQRLNFLYQAAHCVLAQDPENQALARFYCYTERTIAKRLVLRRDPSVKRTLCRGCSSLLVPGLTCTQRQRRCRGQRWTVQTCLTCQRSQRFLNDPGHLLWGDRPEAQLGSQADSKPLQPLPNTAHSISDRLPEEKMQTQGSSNQ

opentargets:
multimeric ribonuclease P complex [GO:0030681]; nucleolar ribonuclease P complex [GO:0005655]; nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; ribonuclease P activity [GO:0004526]; response to drug [GO:0042493]; tRNA 5'-leader removal [GO:0001682]; tRNA processing [GO:0008033]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; Synonyms=CAT60-V1; IsoId=Q9H633-1; Sequence=Displayed; Name=2; Synonyms=CAT60-V3; IsoId=Q9H633-2; Sequence=VSP_010695; Name=3; Synonyms=CAT60-V4; IsoId=Q9H633-3; Sequence=VSP_010696; Name=4; IsoId=Q9H633-4; Sequence=VSP_044901; Note=No experimental confirmation available.; 


uniprotID: Q86X10
geneSymbol: RALGAPB
reactome: R-HSA-1445148;
name: Ral GTPase-activating protein subunit beta (p170)
length: 1494
go: ENSG00000170471;
sequence:

opentargets:
GTPase activator activity [GO:0005096]; protein heterodimerization activity [GO:0046982]; activation of GTPase activity [GO:0090630]; regulation of small GTPase mediated signal transduction [GO:0051056]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q86X10-1; Sequence=Displayed; Name=2; IsoId=Q86X10-2; Sequence=VSP_009693, VSP_009696; Note=May be due to a competing acceptor splice site. No experimental confirmation available.; Name=3; IsoId=Q86X10-3; Sequence=VSP_009694, VSP_009696; Note=May be due to a competing acceptor splice site. No experimental confirmation available.; Name=4; IsoId=Q86X10-4; Sequence=VSP_009695; Note=Splicing acceptor site is not canonical. No experimental confirmation available.; 


uniprotID: Q8NEF9
geneSymbol: SRFBP1
length: 429
go: ENSG00000151304;
location: SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9CZ91}.
name:
Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP)

sequence:

opentargets:
90S preribosome [GO:0030686]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; RNA binding [GO:0003723]; maturation of SSU-rRNA [GO:0030490]


uniprotID: P0DJJ0
geneSymbol: SRGAP2C
name: SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1)
length: 459
go: ENSG00000171943;
sequence:

opentargets:
cytoplasm [GO:0005737]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; Rac GTPase binding [GO:0048365]; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration [GO:0021816]; negative regulation of cell migration [GO:0030336]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of filopodium assembly [GO:0051490]; positive regulation of neuron migration [GO:2001224]


uniprotID: O00411
geneSymbol: POLRMT
reactome: R-HSA-163282;R-HSA-2151201;
pdb: 3SPA;4BOC;5OLA;6ERP;6ERQ;
name: DNA-directed RNA polymerase, mitochondrial (MtRPOL) (EC 2.7.7.6)
length: 1230
go: ENSG00000099821;
snps: rs2238549
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
sequence:

opentargets:
mitochondrial DNA-directed RNA polymerase complex [GO:0034245]; mitochondrial matrix [GO:0005759]; mitochondrial nucleoid [GO:0042645]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; DNA-directed 5'-3' RNA polymerase activity [GO:0003899]; mitochondrial promoter sequence-specific DNA binding [GO:0001018]; RNA binding [GO:0003723]; sequence-specific DNA binding [GO:0043565]; mitochondrial transcription [GO:0006390]; mitochondrion organization [GO:0007005]; transcription initiation from mitochondrial promoter [GO:0006391]


uniprotID: Q9Y3A4
geneSymbol: RRP7A
reactome: R-HSA-6790901;R-HSA-6791226;
name: Ribosomal RNA-processing protein 7 homolog A (Gastric cancer antigen Zg14)
length: 280
go: ENSG00000189306;
snps: rs8139383 rs1812240 rs11553441
sequence:

opentargets:
CURI complex [GO:0032545]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; UTP-C complex [GO:0034456]; RNA binding [GO:0003723]; blastocyst formation [GO:0001825]; ribosomal small subunit assembly [GO:0000028]; rRNA processing [GO:0006364]


uniprotID: Q96EU6
geneSymbol: RRP36
reactome: R-HSA-6790901;R-HSA-6791226;
name: Ribosomal RNA processing protein 36 homolog
length: 259
go: ENSG00000124541;
snps: rs3749903
sequence:

opentargets:
90S preribosome [GO:0030686]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; RNA binding [GO:0003723]; cleavage involved in rRNA processing [GO:0000469]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; ribosomal small subunit biogenesis [GO:0042274]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96EU6-1; Sequence=Displayed; Name=2; IsoId=Q96EU6-2; Sequence=VSP_020884; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:20038530}. Note=Concentrated in the fibrillar region of the nucleolus.


uniprotID: Q15269
geneSymbol: PWP2
reactome: R-HSA-6790901;R-HSA-6791226;
name: Periodic tryptophan protein 2 homolog
length: 919
go: ENSG00000241945;
snps: rs2020945 rs35001460 rs17856422
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; Pwp2p-containing subcomplex of 90S preribosome [GO:0034388]; small-subunit processome [GO:0032040]; RNA binding [GO:0003723]; snoRNA binding [GO:0030515]; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000462]; rRNA processing [GO:0006364]


uniprotID: Q9Y3Y4
geneSymbol: PYGO1
reactome: R-HSA-201722;R-HSA-3769402;
pdb: 2VP7;2VPB;2VPD;2VPE;2VPG;
name: Pygopus homolog 1
length: 419
go: ENSG00000171016;
snps: rs11858624
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
nucleoplasm [GO:0005654]; metal ion binding [GO:0046872]; methylated histone binding [GO:0035064]; beta-catenin-TCF complex assembly [GO:1904837]; canonical Wnt signaling pathway [GO:0060070]; hematopoietic progenitor cell differentiation [GO:0002244]; kidney development [GO:0001822]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic development [GO:0009791]; protein localization to nucleus [GO:0034504]; spermatid nucleus differentiation [GO:0007289]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y3Y4-1; Sequence=Displayed; Name=2; IsoId=Q9Y3Y4-2; Sequence=VSP_056648; 


uniprotID: O14957
geneSymbol: UQCR11
reactome: R-HSA-611105;
pdb: 5XTE;5XTH;5XTI;
sequence: MVTRFLGPRYRELVKNWVPTAYTWGAVGAVGLVWATDWRLILDWVPYINGKFKKDN
length: 56
go: ENSG00000127540;
drug: DB08453;DB07778;DB07401;DB08330;DB08690;
location: SUBCELLULAR LOCATION: Mitochondrion inner membrane.
name:
Cytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 6.4 kDa protein)

opentargets:
integral component of membrane [GO:0016021]; mitochondrial inner membrane [GO:0005743]; respiratory chain [GO:0070469]; electron transfer activity [GO:0009055]; ubiquinol-cytochrome-c reductase activity [GO:0008121]; generation of precursor metabolites and energy [GO:0006091]


uniprotID: Q6NUJ5
geneSymbol: PWWP2B
pdb: 4LD6;
name: PWWP domain-containing protein 2B
length: 590
go: ENSG00000171813;
opentargets: nucleoplasm [GO:0005654]
snps: rs11146363 rs10747057
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q6NUJ5-1; Sequence=Displayed; Name=2; IsoId=Q6NUJ5-2; Sequence=VSP_054223, VSP_054224; 


uniprotID: P11498
geneSymbol: PC
reactome: R-HSA-196780;R-HSA-3371599;R-HSA-70263;
pdb: 3BG3;3BG9;
name: Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)
length: 1178
go: ENSG00000173599;
drug: DB00121;DB00119;
location: SUBCELLULAR LOCATION: Mitochondrion matrix.
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]; ATP binding [GO:0005524]; biotin binding [GO:0009374]; identical protein binding [GO:0042802]; metal ion binding [GO:0046872]; pyruvate carboxylase activity [GO:0004736]; biotin metabolic process [GO:0006768]; gluconeogenesis [GO:0006094]; lipid metabolic process [GO:0006629]; negative regulation of gene expression [GO:0010629]; positive regulation by host of viral process [GO:0044794]; positive regulation by host of viral release from host cell [GO:0044791]; pyruvate metabolic process [GO:0006090]; viral RNA genome packaging [GO:0019074]

snps:
rs7104156 rs28940591 rs119103241 rs1258494752 rs113994143 rs119103242 rs28940589 rs113994145 rs28940590 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P11498-1; Sequence=Displayed; Name=2; IsoId=P11498-2; Sequence=VSP_056358, VSP_056359; Note=No experimental confirmation available.; 


uniprotID: Q9BRQ0
geneSymbol: PYGO2
reactome: R-HSA-201722;R-HSA-3769402;
pdb: 2XB1;4UP0;4UP5;
name: Pygopus homolog 2
length: 406
go: ENSG00000163348;
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
sequence:

opentargets:
beta-catenin-TCF complex [GO:1990907]; nucleoplasm [GO:0005654]; chromatin binding [GO:0003682]; histone acetyltransferase regulator activity [GO:0035034]; histone binding [GO:0042393]; metal ion binding [GO:0046872]; beta-catenin-TCF complex assembly [GO:1904837]; brain development [GO:0007420]; canonical Wnt signaling pathway [GO:0060070]; developmental growth [GO:0048589]; in utero embryonic development [GO:0001701]; kidney development [GO:0001822]; lens development in camera-type eye [GO:0002088]; mammary gland development [GO:0030879]; positive regulation of chromatin binding [GO:0035563]; post-embryonic development [GO:0009791]; regulation of histone H3-K4 methylation [GO:0051569]; regulation of mammary gland epithelial cell proliferation [GO:0033599]; roof of mouth development [GO:0060021]; spermatid nucleus differentiation [GO:0007289]


uniprotID: Q9NX57
geneSymbol: RAB20
reactome: R-HSA-8873719;
name: Ras-related protein Rab-20
length: 234
go: ENSG00000139832;
snps: rs426453
sequence:

opentargets:
early endosome [GO:0005769]; endocytic vesicle [GO:0030139]; endosome [GO:0005768]; Golgi apparatus [GO:0005794]; intracellular membrane-bounded organelle [GO:0043231]; phagocytic vesicle [GO:0045335]; phagocytic vesicle membrane [GO:0030670]; plasma membrane [GO:0005886]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; cellular response to interferon-gamma [GO:0071346]; intracellular protein transport [GO:0006886]; phagosome acidification [GO:0090383]; phagosome-lysosome fusion [GO:0090385]; Rab protein signal transduction [GO:0032482]; regulation of endocytosis [GO:0030100]

location:
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16613320}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000250|UniProtKB:P35295, ECO:0000269|PubMed:21255211}.


uniprotID: Q96HA9
geneSymbol: PEX11G
length: 241
go: ENSG00000104883;
snps: rs2303146
name:
Peroxisomal membrane protein 11C (Peroxin-11C) (Peroxisomal biogenesis factor 11C) (Protein PEX11 homolog gamma) (PEX11-gamma)

sequence:

opentargets:
integral component of peroxisomal membrane [GO:0005779]; intrinsic component of peroxisomal membrane [GO:0031231]; peroxisome [GO:0005777]; protein-containing complex [GO:0032991]; peroxisome fission [GO:0016559]; regulation of peroxisome size [GO:0044375]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q96HA9-1; Sequence=Displayed; Name=2; IsoId=Q96HA9-2; Sequence=VSP_013539; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12417726, ECO:0000269|PubMed:12559946, ECO:0000269|PubMed:20826455}; Multi-pass membrane protein {ECO:0000269|PubMed:12417726, ECO:0000269|PubMed:12559946}.


uniprotID: Q5HYI8
geneSymbol: RABL3
name: Rab-like protein 3
length: 236
go: ENSG00000144840;
sequence:

opentargets:
intracellular [GO:0005622]; GTP binding [GO:0005525]; GTPase activity [GO:0003924]; intracellular protein transport [GO:0006886]; Rab protein signal transduction [GO:0032482]


uniprotID: Q8TBF2
geneSymbol: PRXL2B
reactome: R-HSA-2162123;
length: 198
location: SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9DB60}.
name:
Prostamide/prostaglandin F synthase (Prostamide/PG F synthase) (Prostamide/PGF synthase) (EC 1.11.1.20) (Peroxiredoxin-like 2B) (Protein FAM213B)

sequence:
MSTVDLARVGACILKHAVTGEAVELRSLWREHACVVAGLRRFGCVVCRWIAQDLSSLAGLLDQHGVRLVGVGPEALGLQEFLDGDYFAGELYLDESKQLYKELGFKRYNSLSILPAALGKPVRDVAAKAKAVGIQGNLSGDLLQSGGLLVVSKGGDKVLLHFVQKSPGDYVPKEHILQVLGISAEVCASDPPQCDREV

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum [GO:0005783]; extracellular exosome [GO:0070062]; myelin sheath [GO:0043209]; antioxidant activity [GO:0016209]; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616]; prostaglandin-F synthase activity [GO:0047017]; oxidation-reduction process [GO:0055114]; prostaglandin biosynthetic process [GO:0001516]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=6;  Name=1; IsoId=Q8TBF2-1; Sequence=Displayed; Name=2; IsoId=Q8TBF2-2; Sequence=VSP_024581; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBF2-3; Sequence=VSP_040901; Note=No experimental confirmation available.; Name=4; IsoId=Q8TBF2-4; Sequence=VSP_040903; Note=No experimental confirmation available.; Name=5; IsoId=Q8TBF2-6; Sequence=VSP_040904; Note=No experimental confirmation available.; Name=6; IsoId=Q8TBF2-7; Sequence=VSP_040901, VSP_024581; Note=No experimental confirmation available.; 


uniprotID: Q9H0J4
geneSymbol: QRICH2
name: Glutamine-rich protein 2
length: 1663
go: ENSG00000129646;
snps: rs6501880 rs6501878 rs6501879 rs6501874 rs2279054 rs2279053 rs2279052
sequence:

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q9H0J4-1; Sequence=Displayed; Name=2; IsoId=Q9H0J4-2; Sequence=VSP_027102, VSP_027103; Note=No experimental confirmation available.; Name=3; IsoId=Q9H0J4-3; Sequence=VSP_027101; Note=No experimental confirmation available.; 


uniprotID: Q8NFP0
geneSymbol: PXT1
name: Peroxisomal testis-specific protein 1 (Small testis-specific peroxisomal protein)
length: 134
go: ENSG00000179165;
location: SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
sequence:
MKKKHDGIVYETKEVLNPSPKVTHCCKSLWLKYSFQKAYMTQLVSSQPVPAMSRNPDHNLLSQPKEHSIVQKHHQEEIIHKLAMQLRHIGDNIDHRMVREDLQQDGRDALDHFVFFFFRRVQVLLHFFWNNHLL

opentargets:
nucleus [GO:0005634]; peroxisome [GO:0005777]; positive regulation of apoptotic process [GO:0043065]


uniprotID: Q7Z7A4
geneSymbol: PXK
name: PX domain-containing protein kinase-like protein (Modulator of Na,K-ATPase) (MONaKA)
length: 578
go: ENSG00000168297;
snps: rs55973253 rs56384862 rs34579268 rs34579268
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; microtubule organizing center [GO:0005815]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; protein-containing complex [GO:0032991]; actin binding [GO:0003779]; phosphatidylinositol binding [GO:0035091]; protein C-terminus binding [GO:0008022]; inflammatory response [GO:0006954]; modulation of chemical synaptic transmission [GO:0050804]; negative regulation of ATPase activity [GO:0032780]; negative regulation of ion transport [GO:0043271]; protein phosphorylation [GO:0006468]; regulation of membrane potential [GO:0042391]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=7;  Name=1 {ECO:0000269|PubMed:16135750}; Synonyms=Long {ECO:0000303|PubMed:16135750}, v1 {ECO:0000303|PubMed:16142408}; IsoId=Q7Z7A4-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:16135750}; Synonyms=Short {ECO:0000303|PubMed:16135750}; IsoId=Q7Z7A4-2; Sequence=VSP_051912, VSP_051913; Name=3 {ECO:0000269|PubMed:16142408}; Synonyms=v3 {ECO:0000303|PubMed:16142408}; IsoId=Q7Z7A4-3; Sequence=VSP_051907; Name=4 {ECO:0000305}; IsoId=Q7Z7A4-4; Sequence=VSP_051911; Note=No experimental confirmation available. {ECO:0000305}; Name=5 {ECO:0000269|PubMed:16142408}; Synonyms=v4 {ECO:0000303|PubMed:16142408}; IsoId=Q7Z7A4-5; Sequence=VSP_051908; Name=6 {ECO:0000269|PubMed:16142408}; Synonyms=v2 {ECO:0000303|PubMed:16142408}; IsoId=Q7Z7A4-6; Sequence=VSP_051910; Name=7 {ECO:0000269|PubMed:16142408}; Synonyms=v5 {ECO:0000303|PubMed:16142408}; IsoId=Q7Z7A4-7; Sequence=VSP_051909; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16142408}. Cell membrane {ECO:0000269|PubMed:16142408}; Peripheral membrane protein {ECO:0000269|PubMed:16142408}. Note=Also associates with the plasma membrane. Isoform 3 is present throughout the cell.


uniprotID: Q9H974
geneSymbol: QTRT2
reactome: R-HSA-6782315;
length: 415
go: ENSG00000151576;
name:
Queuine tRNA-ribosyltransferase accessory subunit 2 (Queuine tRNA-ribosyltransferase domain-containing protein 1)

sequence:

opentargets:
cytoplasm [GO:0005737]; mitochondrial outer membrane [GO:0005741]; mitochondrion [GO:0005739]; protein-containing complex [GO:0032991]; metal ion binding [GO:0046872]; protein heterodimerization activity [GO:0046982]; protein homodimerization activity [GO:0042803]; queuine tRNA-ribosyltransferase activity [GO:0008479]; tRNA-guanine transglycosylation [GO:0101030]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9H974-1; Sequence=Displayed; Name=2; IsoId=Q9H974-2; Sequence=VSP_045140; Name=3; IsoId=Q9H974-3; Sequence=VSP_045141; Name=4; IsoId=Q9H974-4; Sequence=VSP_046859; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255|HAMAP-Rule:MF_03043}.


uniprotID: Q8TE99
geneSymbol: PXYLP1
length: 480
go: ENSG00000155893;
name:
2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124)

sequence:

opentargets:
Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; integral component of membrane [GO:0016021]; phosphatase activity [GO:0016791]; chondroitin sulfate proteoglycan biosynthetic process [GO:0050650]; glycosaminoglycan biosynthetic process [GO:0006024]; positive regulation of heparan sulfate proteoglycan biosynthetic process [GO:0010909]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TE99-1; Sequence=Displayed; Name=2; IsoId=Q8TE99-2; Sequence=VSP_030432; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:24425863}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000269|PubMed:24425863}.


uniprotID: Q9H1K0
geneSymbol: RBSN
reactome: R-HSA-168138;R-HSA-983231;
pdb: 1YZM;1Z0J;1Z0K;
length: 784
go: ENSG00000131381;
snps: rs144008665 rs9868848 rs9851219 rs9830744
name:
Rabenosyn-5 (110 kDa protein) (FYVE finger-containing Rab5 effector protein rabenosyn-5) (RAB effector RBSN) (Zinc finger FYVE domain-containing protein 20)

sequence:

opentargets:
cytosol [GO:0005829]; early endosome membrane [GO:0031901]; endosome [GO:0005768]; endosome membrane [GO:0010008]; extracellular exosome [GO:0070062]; intracellular membrane-bounded organelle [GO:0043231]; plasma membrane [GO:0005886]; nucleic acid binding [GO:0003676]; Rab GTPase binding [GO:0017137]; zinc ion binding [GO:0008270]; blood coagulation [GO:0007596]; early endosome to Golgi transport [GO:0034498]; endosomal transport [GO:0016197]; Golgi to lysosome transport [GO:0090160]; protein transport [GO:0015031]; regulation of Golgi organization [GO:1903358]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9H1K0-1; Sequence=Displayed; Name=2; IsoId=Q9H1K0-2; Sequence=VSP_056003, VSP_056004; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane {ECO:0000269|PubMed:22308388}; Lipid-anchor. Note=Enriched in endosomes that are in close proximity to clathrin-enriched regions at the cell surface. {ECO:0000269|PubMed:22308388}.


uniprotID: Q9Y2P8
geneSymbol: RCL1
reactome: R-HSA-6790901;R-HSA-6791226;
name: RNA 3'-terminal phosphate cyclase-like protein
length: 373
go: ENSG00000120158;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
sequence:

opentargets:
nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; endoribonuclease activity [GO:0004521]; endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000480]; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [GO:0000447]; rRNA processing [GO:0006364]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9Y2P8-1; Sequence=Displayed; Name=2; IsoId=Q9Y2P8-2; Sequence=VSP_056452, VSP_056453; Note=No experimental confirmation available.; 


uniprotID: A6NDE4
geneSymbol: RBMY1B
name: RNA-binding motif protein, Y chromosome, family 1 member B
length: 496
location: SUBCELLULAR LOCATION: Nucleus.
sequence:

opentargets:
nucleus [GO:0005634]; ribonucleoprotein complex [GO:1990904]; spliceosomal complex [GO:0005681]; RNA binding [GO:0003723]; male gonad development [GO:0008584]; mRNA processing [GO:0006397]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; RNA splicing [GO:0008380]; spermatogenesis [GO:0007283]


uniprotID: Q0VAM2
geneSymbol: RASGEF1B
name: Ras-GEF domain-containing family member 1B (GPI gamma-4)
length: 473
go: ENSG00000138670;
sequence:

opentargets:
early endosome [GO:0005769]; late endosome [GO:0005770]; midbody [GO:0030496]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; positive regulation of GTPase activity [GO:0043547]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q0VAM2-1; Sequence=Displayed; Name=2; IsoId=Q0VAM2-2; Sequence=VSP_027313, VSP_027314; Name=3; IsoId=Q0VAM2-3; Sequence=VSP_027314; 

location:
SUBCELLULAR LOCATION: Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Midbody {ECO:0000269|PubMed:23894443}. Note=May shuttle between early and late endosomes (By similarity). Localizes to midbody at telophase. {ECO:0000250}.


uniprotID: P40937
geneSymbol: RFC5
pdb: 1LFS;
length: 340
go: ENSG00000111445;
snps: rs5745796
location: SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
reactome:
R-HSA-110312;R-HSA-110314;R-HSA-110320;R-HSA-174411;R-HSA-176187;R-HSA-5651801;R-HSA-5655862;R-HSA-5656121;R-HSA-5656169;R-HSA-5685938;R-HSA-5685942;R-HSA-5693607;R-HSA-5693616;R-HSA-5696397;R-HSA-5696400;R-HSA-6782135;R-HSA-6782210;R-HSA-6804756;R-HSA-69091;R-HSA-69473;

name:
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)

sequence:

opentargets:
Ctf18 RFC-like complex [GO:0031390]; DNA replication factor C complex [GO:0005663]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; ATP binding [GO:0005524]; DNA binding [GO:0003677]; enzyme binding [GO:0019899]; DNA damage response, detection of DNA damage [GO:0042769]; DNA repair [GO:0006281]; DNA replication [GO:0006260]; DNA-dependent DNA replication [GO:0006261]; error-free translesion synthesis [GO:0070987]; error-prone translesion synthesis [GO:0042276]; nucleotide-excision repair, DNA gap filling [GO:0006297]; nucleotide-excision repair, DNA incision [GO:0033683]; nucleotide-excision repair, DNA incision, 5'-to lesion [GO:0006296]; positive regulation of DNA-directed DNA polymerase activity [GO:1900264]; telomere maintenance via semi-conservative replication [GO:0032201]; transcription-coupled nucleotide-excision repair [GO:0006283]; translesion synthesis [GO:0019985]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=P40937-1; Sequence=Displayed; Name=2; IsoId=P40937-2; Sequence=VSP_043067; Note=No experimental confirmation available.; 


uniprotID: Q9BXF6
geneSymbol: RAB11FIP5
length: 653
go: ENSG00000135631;
name:
Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11)

sequence:

opentargets:
early endosome [GO:0005769]; early endosome membrane [GO:0031901]; Golgi apparatus [GO:0005794]; Golgi membrane [GO:0000139]; intracellular membrane-bounded organelle [GO:0043231]; microtubule organizing center [GO:0005815]; mitochondrial outer membrane [GO:0005741]; recycling endosome [GO:0055037]; recycling endosome membrane [GO:0055038]; secretory granule [GO:0030141]; transport vesicle membrane [GO:0030658]; gamma-tubulin binding [GO:0043015]; Rab GTPase binding [GO:0017137]; cellular response to acidic pH [GO:0071468]; insulin secretion involved in cellular response to glucose stimulus [GO:0035773]; negative regulation of adiponectin secretion [GO:0070164]; regulated exocytosis [GO:0045055]; regulation of protein localization to cell surface [GO:2000008]

location:
SUBCELLULAR LOCATION: Cytoplasm. Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion membrane; Peripheral membrane protein.


uniprotID: O75916
geneSymbol: RGS9
reactome: R-HSA-2514859;R-HSA-418594;R-HSA-6814122;
name: Regulator of G-protein signaling 9 (RGS9)
length: 674
go: ENSG00000108370;
snps: rs12452285 rs121908449
sequence:

opentargets:
cytoplasm [GO:0005737]; glutamatergic synapse [GO:0098978]; nucleus [GO:0005634]; photoreceptor disc membrane [GO:0097381]; postsynaptic density membrane [GO:0098839]; GTPase activator activity [GO:0005096]; dopamine receptor signaling pathway [GO:0007212]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; nervous system development [GO:0007399]; positive regulation of NMDA glutamate receptor activity [GO:1904783]; protein folding [GO:0006457]; regulation of calcium ion export across plasma membrane [GO:1905912]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; response to amphetamine [GO:0001975]; response to estradiol [GO:0032355]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=5;  Name=1; Synonyms=RGS9L; IsoId=O75916-1; Sequence=Displayed; Name=2; Synonyms=RGS9S; IsoId=O75916-2; Sequence=VSP_005675; Name=3; Synonyms=RGS9-1; IsoId=O75916-3; Sequence=VSP_038381, VSP_038382, VSP_038383; Name=4; IsoId=O75916-4; Sequence=VSP_005674; Name=5; IsoId=O75916-5; Sequence=VSP_038381; 

location:
SUBCELLULAR LOCATION: Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP. {ECO:0000250}.


uniprotID: Q2M5E4
geneSymbol: RGS21
reactome: R-HSA-416476;R-HSA-418594;
name: Regulator of G-protein signaling 21 (RGS21)
length: 152
go: ENSG00000253148;
opentargets: negative regulation of signal transduction [GO:0009968]
sequence:
MPVKCCFYRSPTAETMTWSENMDTLLANQAGLDAFRIFLKSEFSEENVEFWLACEDFKKTKNADKIASKAKMIYSEFIEADAPKEINIDFGTRDLISKNIAEPTLKCFDEAQKLIYCLMAKDSFPRFLKSEIYKKLVNSQQVPNHKKWLPFL


uniprotID: P41220
geneSymbol: RGS2
reactome: R-HSA-416476;
pdb: 2AF0;2V4Z;4EKC;4EKD;
length: 211
go: ENSG00000116741;
name:
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)

sequence:

opentargets:
cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]; mitochondrion [GO:0005739]; neuron projection [GO:0043005]; nucleolus [GO:0005730]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; beta-tubulin binding [GO:0048487]; calmodulin binding [GO:0005516]; G-protein alpha-subunit binding [GO:0001965]; GTPase activator activity [GO:0005096]; brain development [GO:0007420]; brown fat cell differentiation [GO:0050873]; cell cycle [GO:0007049]; maternal process involved in female pregnancy [GO:0060135]; negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process [GO:0140194]; negative regulation of cAMP-mediated signaling [GO:0043951]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of cell growth involved in cardiac muscle cell development [GO:0061052]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]; negative regulation of glycine import across plasma membrane [GO:1900924]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of phospholipase activity [GO:0010519]; negative regulation of translation [GO:0017148]; ovulation [GO:0030728]; positive regulation of cardiac muscle contraction [GO:0060452]; positive regulation of neuron projection development [GO:0010976]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]; relaxation of cardiac muscle [GO:0055119]; relaxation of vascular smooth muscle [GO:0060087]; response to amphetamine [GO:0001975]; response to ethanol [GO:0045471]; spermatogenesis [GO:0007283]

snps:
rs141030117 rs145125159 rs142499684 rs193051407 rs74466425 rs148489044 rs201233692 rs200339834 rs80221024 rs140811638 rs139237239 rs146862218 rs369752935 rs112707798 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative initiation; Named isoforms=4;  Name=1; IsoId=P41220-1; Sequence=Displayed; Name=2; IsoId=P41220-2; Sequence=VSP_041296; Name=3; IsoId=P41220-3; Sequence=VSP_041297; Note=Lacks type V adenylyl cyclase (AC) inhibitory function.; Name=4; IsoId=P41220-4; Sequence=VSP_041298; Note=Lacks type V adenylyl cyclase (AC) inhibitory function.; 

location:
SUBCELLULAR LOCATION: Isoform 1: Cell membrane {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199, ECO:0000269|PubMed:28784619}. Cytoplasm {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:11278586, ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane {ECO:0000269|PubMed:17901199}. Cytoplasm {ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane {ECO:0000269|PubMed:17901199}. Cytoplasm {ECO:0000269|PubMed:17901199}. Nucleus, nucleolus {ECO:0000269|PubMed:17901199}.; SUBCELLULAR LOCATION: Isoform 4: Cell membrane {ECO:0000269|PubMed:17901199}. Mitochondrion {ECO:0000269|PubMed:17901199}.


uniprotID: P49796
geneSymbol: RGS3
reactome: R-HSA-416476;
pdb: 2F5Y;2OJ4;3FBK;
name: Regulator of G-protein signaling 3 (RGP3) (RGS3)
length: 1198
go: ENSG00000138835;
snps: rs16933949 rs41305473
sequence:

opentargets:
cytosol [GO:0005829]; nucleoplasm [GO:0005654]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; inactivation of MAPK activity [GO:0000188]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=9;  Name=3; IsoId=P49796-3; Sequence=Displayed; Name=1; IsoId=P49796-1; Sequence=VSP_013958; Name=2; Synonyms=RGS3T; IsoId=P49796-2; Sequence=VSP_005662; Note=Nuclear. {ECO:0000269|PubMed:10749886}; Name=4; Synonyms=1; IsoId=P49796-4; Sequence=VSP_013959, VSP_013963; Name=5; IsoId=P49796-5; Sequence=VSP_013961, VSP_013962, VSP_013964, VSP_013965; Name=6; Synonyms=C2PA-RGS3; IsoId=P49796-6; Sequence=VSP_013960; Name=7; IsoId=P49796-7; Sequence=VSP_047029; Note=No experimental confirmation available.; Name=8; Synonyms=RGS3S; IsoId=P49796-8; Sequence=VSP_047029, VSP_053533; Name=9; IsoId=P49796-9; Sequence=VSP_013959, VSP_013963, VSP_054690; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9858594}. Nucleus {ECO:0000269|PubMed:10749886}. Cell membrane {ECO:0000269|PubMed:9858594}; Peripheral membrane protein {ECO:0000269|PubMed:9858594}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane (PubMed:9858594). Short isoforms are nuclear (PubMed:10749886).


uniprotID: Q96B86
geneSymbol: RGMA
reactome: R-HSA-373752;
pdb: 4UHY;
name: Repulsive guidance molecule A (RGM domain family member A)
length: 450
snps: rs4238485 rs4778078
location: SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
sequence:

opentargets:
anchored component of membrane [GO:0031225]; endoplasmic reticulum [GO:0005783]; plasma membrane [GO:0005886]; coreceptor activity [GO:0015026]; transferrin receptor binding [GO:1990459]; BMP signaling pathway [GO:0030509]; negative regulation of axon regeneration [GO:0048681]; positive regulation of transcription by RNA polymerase II [GO:0045944]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q96B86-1; Sequence=Displayed; Name=2; IsoId=Q96B86-3; Sequence=VSP_054070; Name=3; IsoId=Q96B86-4; Sequence=VSP_054071; Note=No experimental confirmation available.; 


uniprotID: Q13972
geneSymbol: RASGRF1
reactome: R-HSA-442982;R-HSA-5673001;
length: 1273
go: ENSG00000058335;
name:
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)

sequence:

opentargets:
cytosol [GO:0005829]; growth cone [GO:0030426]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; glutamate receptor binding [GO:0035254]; guanyl-nucleotide exchange factor activity [GO:0005085]; Ras guanyl-nucleotide exchange factor activity [GO:0005088]; Rho guanyl-nucleotide exchange factor activity [GO:0005089]; activation of GTPase activity [GO:0090630]; cell proliferation [GO:0008283]; long-term memory [GO:0007616]; MAPK cascade [GO:0000165]; neuron projection development [GO:0031175]; positive regulation of GTPase activity [GO:0043547]; positive regulation of Ras protein signal transduction [GO:0046579]; regulation of neuronal synaptic plasticity [GO:0048168]; regulation of NMDA receptor activity [GO:2000310]; regulation of Rac protein signal transduction [GO:0035020]; regulation of Ras protein signal transduction [GO:0046578]; regulation of Rho protein signal transduction [GO:0035023]; regulation of synaptic plasticity [GO:0048167]; response to endoplasmic reticulum stress [GO:0034976]; signal transduction [GO:0007165]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q13972-1; Sequence=Displayed; Name=2; IsoId=Q13972-2; Sequence=VSP_012032; Name=3; IsoId=Q13972-3; Sequence=VSP_054072, VSP_054073; 


uniprotID: P49758
geneSymbol: RGS6
reactome: R-HSA-418594;R-HSA-6814122;
pdb: 2ES0;
name: Regulator of G-protein signaling 6 (RGS6) (S914)
length: 472
go: ENSG00000182732;
sequence:

opentargets:
cytosol [GO:0005829]; extrinsic component of membrane [GO:0019898]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; GTPase activator activity [GO:0005096]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; positive regulation of GTPase activity [GO:0043547]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=15;  Comment=Additional isoforms seem to exist. {ECO:0000269|PubMed:12761221}; Name=1; Synonyms=RGS6Lalpha2; IsoId=P49758-4; Sequence=Displayed; Name=2; Synonyms=RGS6Lgamma1, RGS6Lbeta1 {ECO:0000303|PubMed:12761221}; IsoId=P49758-2; Sequence=VSP_035848; Name=3; Synonyms=RGS6Lalpha1; IsoId=P49758-3; Sequence=VSP_035847; Name=5; Synonyms=RGS6Lbeta; IsoId=P49758-5; Sequence=VSP_035849; Name=6; Synonyms=RGS6Lbeta-GGL; IsoId=P49758-6; Sequence=VSP_035846, VSP_035849; Name=7; Synonyms=RGS6Lalpha2-GGL; IsoId=P49758-7; Sequence=VSP_035846; Name=8; Synonyms=RGS6Lgamma2, RGS6Lbeta2 {ECO:0000303|PubMed:12761221}; IsoId=P49758-8; Sequence=VSP_035850; Name=9; Synonyms=RGS6Lalpha1-GGL; IsoId=P49758-9; Sequence=VSP_035846, VSP_035847; Name=10; Synonyms=RGS6Lgamma1-GGL; IsoId=P49758-10; Sequence=VSP_035846, VSP_035848; Name=11; Synonyms=RGS6Lgamma2-GGL; IsoId=P49758-11; Sequence=VSP_035846, VSP_035850; Name=12; Synonyms=RGS6Sbeta1 {ECO:0000303|PubMed:12761221}; IsoId=P49758-12; Sequence=VSP_035845, VSP_035848; Name=13; Synonyms=RGS6Lepsilon; IsoId=P49758-13; Sequence=VSP_047806; Name=14; Synonyms=RGS6Ldelta; IsoId=P49758-14; Sequence=VSP_047807; Name=15; Synonyms=RGS6Lgamma; IsoId=P49758-15; Sequence=VSP_047808; Name=16; Synonyms=RGS6Leta; IsoId=P49758-16; Sequence=VSP_047809; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12761221}. Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Membrane {ECO:0000269|PubMed:10521509}; Peripheral membrane protein {ECO:0000269|PubMed:10521509}. Nucleus {ECO:0000269|PubMed:12761221}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with GNB5 mediates translocation to the nucleus. {ECO:0000269|PubMed:12761221}.


uniprotID: O94810
geneSymbol: RGS11
reactome: R-HSA-418594;R-HSA-6814122;
name: Regulator of G-protein signaling 11 (RGS11)
length: 467
go: ENSG00000076344;
snps: rs9806942 rs739999
sequence:

opentargets:
intracellular [GO:0005622]; protein-containing complex [GO:0032991]; G-protein beta-subunit binding [GO:0031681]; GTPase activator activity [GO:0005096]; G protein-coupled receptor signaling pathway [GO:0007186]; intracellular signal transduction [GO:0035556]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=O94810-1; Sequence=Displayed; Name=2; IsoId=O94810-2; Sequence=VSP_023497; Name=3; IsoId=O94810-3; Sequence=VSP_046724; 


uniprotID: O14921
geneSymbol: RGS13
reactome: R-HSA-418594;
name: Regulator of G-protein signaling 13 (RGS13)
length: 159
go: ENSG00000127074;
snps: rs16834603
sequence:
MSRRNCWICKMCRDESKRPPSNLTLEEVLQWAQSFENLMATKYGPVVYAAYLKMEHSDENIQFWMACETYKKIASRWSRISRAKKLYKIYIQPQSPREINIDSSTRETIIRNIQEPTETCFEEAQKIVYMHMERDSYPRFLKSEMYQKLLKTMQSNNSF

opentargets:
cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of G protein-coupled receptor signaling pathway [GO:0045744]


uniprotID: Q9NS28
geneSymbol: RGS18
reactome: R-HSA-416476;R-HSA-418594;
pdb: 2DLV;2JM5;2OWI;
name: Regulator of G-protein signaling 18 (RGS18)
length: 235
go: ENSG00000150681;
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
sequence:

opentargets:
cytoplasm [GO:0005737]; GTPase activator activity [GO:0005096]; G protein-coupled receptor signaling pathway [GO:0007186]; negative regulation of signal transduction [GO:0009968]; regulation of G protein-coupled receptor signaling pathway [GO:0008277]


uniprotID: Q9BSD3
geneSymbol: RHNO1
reactome: R-HSA-5685938;R-HSA-5693607;R-HSA-5693616;R-HSA-6804756;R-HSA-69473;
length: 238
go: ENSG00000171792;
name:
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RAD9, RAD1, HUS1-interacting nuclear orphan protein)

sequence:

opentargets:
chromosome [GO:0005694]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; cell cycle [GO:0007049]; cellular response to ionizing radiation [GO:0071479]; cellular response to UV [GO:0034644]; DNA damage checkpoint [GO:0000077]; positive regulation of G0 to G1 transition [GO:0070318]; recombinational repair [GO:0000725]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BSD3-1; Sequence=Displayed; Name=2; IsoId=Q9BSD3-2; Sequence=VSP_045307; 

location:
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20811708}. Chromosome {ECO:0000269|PubMed:20811708}. Note=Localizes to sites of DNA damage in a H2AX-independent manner.


uniprotID: Q9P2N2
geneSymbol: ARHGAP28
reactome: R-HSA-194840;
name: Rho GTPase-activating protein 28 (Rho-type GTPase-activating protein 28)
length: 729
go: ENSG00000088756;
snps: rs2303978 rs6506448 rs1056408
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; negative regulation of GTP binding [GO:1904425]; negative regulation of stress fiber assembly [GO:0051497]; regulation of actin cytoskeleton organization [GO:0032956]; regulation of actin filament polymerization [GO:0030833]; regulation of small GTPase mediated signal transduction [GO:0051056]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=4;  Name=1; IsoId=Q9P2N2-1; Sequence=Displayed; Name=2; IsoId=Q9P2N2-2; Sequence=VSP_023726, VSP_023728; Name=3; IsoId=Q9P2N2-3; Sequence=VSP_023725, VSP_023727, VSP_023728; Note=No experimental confirmation available.; Name=5; IsoId=Q9P2N2-5; Sequence=VSP_039971; Note=No experimental confirmation available.; 


uniprotID: Q9UHA3
geneSymbol: RSL24D1
length: 163
go: ENSG00000137876;
drug: DB02494;DB07374;DB08437;
location: SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
name:
Probable ribosome biogenesis protein RLP24 (Ribosomal L24 domain-containing protein 1) (Ribosomal protein L24-like)

sequence:
MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVRWTKAFRKAAGKELTVDNSFEFEKRRNEPIKYQRELWNKTIDAMKRVEEIKQKRQAKFIMNRLKKNKELQKVQDIKEVKQNIHLIRAPLAGKGKQLEEKMVQQLQEDVDMEDAP

opentargets:
cytosolic large ribosomal subunit [GO:0022625]; nucleolus [GO:0005730]; nucleus [GO:0005634]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; assembly of large subunit precursor of preribosome [GO:1902626]; ribosomal large subunit assembly [GO:0000027]; translation [GO:0006412]


uniprotID: Q9BYD3
geneSymbol: MRPL4
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 311
go: ENSG00000105364;
name:
39S ribosomal protein L4, mitochondrial (L4mt) (MRP-L4) (Mitochondrial large ribosomal subunit protein uL4m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; Synonyms=isoform a; IsoId=Q9BYD3-1; Sequence=Displayed; Name=2; Synonyms=isoform b; IsoId=Q9BYD3-2; Sequence=VSP_019027, VSP_019028; 


uniprotID: Q9BYD2
geneSymbol: MRPL9
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 267
go: ENSG00000143436;
snps: rs7007 rs8480
name:
39S ribosomal protein L9, mitochondrial (L9mt) (MRP-L9) (Mitochondrial large ribosomal subunit protein bL9m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q9NRX2
geneSymbol: MRPL17
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 2CQM;3J7Y;3J9M;5OOL;5OOM;
length: 175
go: ENSG00000158042;
name:
39S ribosomal protein L17, mitochondrial (L17mt) (MRP-L17) (LYST-interacting protein 2) (Mitochondrial large ribosomal subunit protein bL17m)

sequence:
MRLSVAAAISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEAPWARVDEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTGGYTRMLQIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQSQEASNHSSHTAQTPGI

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; protein domain specific binding [GO:0019904]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]


uniprotID: Q9H0U6
geneSymbol: MRPL18
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;5OOL;5OOM;
length: 180
go: ENSG00000112110;
snps: rs1128670
location: SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:28892042}.
name:
39S ribosomal protein L18, mitochondrial (L18mt) (MRP-L18) (Mitochondrial large ribosomal subunit protein uL18m)

sequence:
MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE

opentargets:
extracellular space [GO:0005615]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; 5S rRNA binding [GO:0008097]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; rRNA import into mitochondrion [GO:0035928]; translation [GO:0006412]


uniprotID: P49406
geneSymbol: MRPL19
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 292
go: ENSG00000115364;
name:
39S ribosomal protein L19, mitochondrial (L19mt) (MRP-L19) (39S ribosomal protein L15, mitochondrial) (L15mt) (MRP-L15) (Mitochondrial large ribosomal subunit protein bL19m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; nuclear membrane [GO:0031965]; nucleus [GO:0005634]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10600119, ECO:0000269|PubMed:11543634, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: Q9BYC9
geneSymbol: MRPL20
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 149
go: ENSG00000242485;
name:
39S ribosomal protein L20, mitochondrial (L20mt) (MRP-L20) (Mitochondrial large ribosomal subunit protein bL20m)

sequence:
MVFLTAQLWLRNRVTDRYFRIQEVLKHARHFRGRKNRCYRLAVRTVIRAFVKCTKARYLKKKNMRTLWINRITAASQEHGLKYPALIGNLVKCQVELNRKVLADLAIYEPKTFKSLAALASRRRHEGFAAALGDGKEPEGIFSRVVQYH

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; rRNA binding [GO:0019843]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; ribosomal large subunit assembly [GO:0000027]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BYC9-1; Sequence=Displayed; Name=2; IsoId=Q9BYC9-2; Sequence=VSP_056084; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11279069, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}.


uniprotID: Q7Z2W9
geneSymbol: MRPL21
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 205
go: ENSG00000197345;
name:
39S ribosomal protein L21, mitochondrial (L21mt) (MRP-L21) (Mitochondrial large ribosomal subunit protein bL21m)

sequence:

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q7Z2W9-1; Sequence=Displayed; Name=2; IsoId=Q7Z2W9-2; Sequence=VSP_045633; Note=No experimental confirmation available.; 


uniprotID: Q86UR5
geneSymbol: RIMS1
reactome: R-HSA-181429;R-HSA-181430;R-HSA-210500;R-HSA-212676;R-HSA-264642;R-HSA-888590;
pdb: 2CSS;
length: 1692
go: ENSG00000079841;
snps: rs121918302
name:
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)

sequence:

opentargets:
cell junction [GO:0030054]; cytoskeleton of presynaptic active zone [GO:0048788]; cytosol [GO:0005829]; plasma membrane [GO:0005886]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; GTPase regulator activity [GO:0030695]; ion channel binding [GO:0044325]; metal ion binding [GO:0046872]; Rab GTPase binding [GO:0017137]; RNA binding [GO:0003723]; calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; intracellular protein transport [GO:0006886]; membrane fusion [GO:0061025]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic transmission [GO:0050806]; protein-containing complex assembly [GO:0065003]; regulated exocytosis [GO:0045055]; regulation of membrane potential [GO:0042391]; regulation of neurotransmitter secretion [GO:0046928]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]; response to stimulus [GO:0050896]; secretion [GO:0046903]; synaptic vesicle exocytosis [GO:0016079]; visual perception [GO:0007601]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=13;  Comment=Additional isoforms seem to exist.; Name=1; Synonyms=RIM1 alpha; IsoId=Q86UR5-1; Sequence=Displayed; Name=2; Synonyms=RIM short form; IsoId=Q86UR5-2; Sequence=VSP_008165; Note=May be due to intron retention.; Name=3; Synonyms=RIM long form, Rab3 interacting protein variant 2; IsoId=Q86UR5-3; Sequence=VSP_008164, VSP_008167, VSP_008171; Name=4; Synonyms=Rab3 interacting protein variant 1; IsoId=Q86UR5-4; Sequence=VSP_008166, VSP_008167; Name=5; Synonyms=Rab3 interacting protein variant 3; IsoId=Q86UR5-5; Sequence=VSP_008161, VSP_008163, VSP_008170; Name=6; Synonyms=Rab3 interacting protein variant 4; IsoId=Q86UR5-6; Sequence=VSP_008164, VSP_008168, VSP_008169; Name=7; Synonyms=Rab3 interacting protein variant 5; IsoId=Q86UR5-7; Sequence=VSP_008161, VSP_008164, VSP_008167, VSP_008169; Name=8; Synonyms=Rab3 interacting protein variant 6; IsoId=Q86UR5-8; Sequence=VSP_008161, VSP_008162, VSP_008169; Name=9; IsoId=Q86UR5-9; Sequence=VSP_043177, VSP_043178, VSP_008164, VSP_043179, VSP_043180, VSP_008169; Note=No experimental confirmation available.; Name=10; IsoId=Q86UR5-10; Sequence=VSP_045486, VSP_008164, VSP_043179, VSP_043180, VSP_008169; Note=No experimental confirmation available.; Name=11; IsoId=Q86UR5-11; Sequence=VSP_045485; Note=No experimental confirmation available.; Name=12; IsoId=Q86UR5-12; Sequence=VSP_046796, VSP_008161, VSP_008164, VSP_043179, VSP_043180; Name=13; IsoId=Q86UR5-13; Sequence=VSP_046796, VSP_008164, VSP_008167, VSP_008169; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.


uniprotID: Q16540
geneSymbol: MRPL23
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 153
go: ENSG00000214026;
snps: rs34134444 rs2240197 rs6512 rs4930142 rs12812
name:
39S ribosomal protein L23, mitochondrial (L23mt) (MRP-L23) (L23 mitochondrial-related protein) (Mitochondrial large ribosomal subunit protein uL23m) (Ribosomal protein L23-like)

sequence:
MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRIPMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLAHGQTFTFPDLFPEKDESPEGSAADDLYSMLEEERQQRQSSDPRRGGVPSWFGL

opentargets:
fibrillar center [GO:0001650]; mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translation [GO:0032543]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q9UQ26
geneSymbol: RIMS2
pdb: 1V27;1WFG;
length: 1411
go: ENSG00000176406;
name:
Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3)

sequence:

opentargets:
cell junction [GO:0030054]; cytoskeleton of presynaptic active zone [GO:0048788]; extracellular exosome [GO:0070062]; presynaptic active zone [GO:0048786]; presynaptic active zone cytoplasmic component [GO:0098831]; presynaptic membrane [GO:0042734]; synapse [GO:0045202]; ion channel binding [GO:0044325]; metal ion binding [GO:0046872]; Rab GTPase binding [GO:0017137]; calcium ion regulated exocytosis [GO:0017156]; calcium ion-regulated exocytosis of neurotransmitter [GO:0048791]; cAMP-mediated signaling [GO:0019933]; insulin secretion [GO:0030073]; intracellular protein transport [GO:0006886]; positive regulation of dendrite extension [GO:1903861]; positive regulation of excitatory postsynaptic potential [GO:2000463]; positive regulation of gene expression [GO:0010628]; positive regulation of inhibitory postsynaptic potential [GO:0097151]; positive regulation of synaptic transmission [GO:0050806]; regulation of exocytosis [GO:0017157]; regulation of membrane potential [GO:0042391]; regulation of synaptic plasticity [GO:0048167]; regulation of synaptic vesicle exocytosis [GO:2000300]; spontaneous neurotransmitter secretion [GO:0061669]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=8;  Name=6; Synonyms=RIM2-alpha; IsoId=Q9UQ26-6; Sequence=Displayed; Note=No experimental confirmation available.; Name=1; Synonyms=RIM2-beta; IsoId=Q9UQ26-1; Sequence=VSP_040865, VSP_040866; Name=2; IsoId=Q9UQ26-2; Sequence=VSP_040872, VSP_040873; Note=May be due to an intron retention. No experimental confirmation available.; Name=3; IsoId=Q9UQ26-3; Sequence=VSP_040865, VSP_040866, VSP_040867, VSP_040874; Note=No experimental confirmation available.; Name=4; Synonyms=RimL3a; IsoId=Q9UQ26-4; Sequence=VSP_040868, VSP_040871; Note=May be due to an intron retention. No experimental confirmation available.; Name=5; Synonyms=RimL3c; IsoId=Q9UQ26-5; Sequence=VSP_040869, VSP_040870; Note=May be due to an intron retention. No experimental confirmation available.; Name=7; Synonyms=RIM2-gamma; IsoId=Q9UQ26-7; Sequence=VSP_040864, VSP_040875; Name=8; IsoId=Q9UQ26-8; Sequence=VSP_044661, VSP_040867, VSP_044662; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.


uniprotID: P13489
geneSymbol: RNH1
pdb: 1A4Y;1Z7X;2BEX;2Q4G;
length: 461
go: ENSG00000023191;
snps: rs17585
location: SUBCELLULAR LOCATION: Cytoplasm.
name:
Ribonuclease inhibitor (Placental ribonuclease inhibitor) (Placental RNase inhibitor) (Ribonuclease/angiogenin inhibitor 1) (RAI)

sequence:

opentargets:
angiogenin-PRI complex [GO:0032311]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; nucleoplasm [GO:0005654]; ribonuclease inhibitor activity [GO:0008428]; mRNA catabolic process [GO:0006402]; regulation of angiogenesis [GO:0045765]


uniprotID: Q8WYP3
geneSymbol: RIN2
reactome: R-HSA-8876198;
length: 895
go: ENSG00000132669;
snps: rs3803981 rs199603
location: SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
name:
Ras and Rab interactor 2 (Ras association domain family 4) (Ras inhibitor JC265) (Ras interaction/interference protein 2)

sequence:

opentargets:
cytosol [GO:0005829]; GTPase activator activity [GO:0005096]; GTPase regulator activity [GO:0030695]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; endocytosis [GO:0006897]; small GTPase mediated signal transduction [GO:0007264]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8WYP3-1; Sequence=Displayed; Name=2; IsoId=Q8WYP3-2; Sequence=VSP_015145; Note=No experimental confirmation available.; 


uniprotID: Q8TB24
geneSymbol: RIN3
reactome: R-HSA-8876198;
pdb: 3U23;4WCI;
name: Ras and Rab interactor 3 (Ras interaction/interference protein 3)
length: 985
go: ENSG00000100599;
snps: rs2274542 rs3829947 rs3829947 rs3829947 rs3742717 rs3742717 rs12434929
sequence:

opentargets:
cytoplasmic vesicle [GO:0031410]; cytosol [GO:0005829]; early endosome [GO:0005769]; GTPase activator activity [GO:0005096]; Rab GTPase binding [GO:0017137]; Rab guanyl-nucleotide exchange factor activity [GO:0017112]; endocytosis [GO:0006897]; signal transduction [GO:0007165]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q8TB24-1; Sequence=Displayed; Name=4; IsoId=Q8TB24-4; Sequence=VSP_007587, VSP_007588; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Cytoplasmic vesicle {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Early endosome {ECO:0000269|PubMed:18486601}. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000269|PubMed:18486601}.


uniprotID: Q8TCC3
geneSymbol: MRPL30
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 161
go: ENSG00000185414;
snps: rs1044575
name:
39S ribosomal protein L30, mitochondrial (L30mt) (MRP-L30) (39S ribosomal protein L28, mitochondrial) (L28mt) (MRP-L28) (Mitochondrial large ribosomal subunit protein uL30m)

sequence:
MAGILRLVVQWPPGRLQTVTKGVESLICTDWIRHKFTRSRIPEKVFQASPEDHEKYGGDPQNPHKLHIVTRIKSTRRRPYWEKDIIKMLGLEKAHTPQVHKNIPSVNAKLKVVKHLIRIKPLKLPQGLPAEENMSNTCLKSTGELVVQWHLKPVEQKAHES

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrion [GO:0005739]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=3;  Name=1; IsoId=Q8TCC3-1; Sequence=Displayed; Name=2; IsoId=Q8TCC3-2; Sequence=VSP_021746; Note=No experimental confirmation available.; Name=3; IsoId=Q8TCC3-3; Sequence=VSP_021747; Note=No experimental confirmation available.; 


uniprotID: Q9BYC8
geneSymbol: MRPL32
reactome: R-HSA-5368286;R-HSA-5389840;R-HSA-5419276;
pdb: 3J7Y;3J9M;5OOL;5OOM;
length: 188
go: ENSG00000106591;
name:
39S ribosomal protein L32, mitochondrial (L32mt) (MRP-L32) (Mitochondrial large ribosomal subunit protein bL32m)

sequence:
MALAMLVLVVSPWSAARGVLRNYWERLLRKLPQSRPGFPSPPWGPALAVQGPAMFTEPANDTSGSKENSSLLDSIFWMAAPKNRRTIEVNRCRRRNPQKLIKVKNNIDVCPECGHLKQKHVLCAYCYEKVCKETAEIRRQIGKQEGGPFKAPTIETVVLYTGETPSEQDQGKRIIERDRKRPSWFTQN

opentargets:
mitochondrial inner membrane [GO:0005743]; mitochondrial large ribosomal subunit [GO:0005762]; mitochondrial ribosome [GO:0005761]; mitochondrion [GO:0005739]; RNA binding [GO:0003723]; structural constituent of ribosome [GO:0003735]; mitochondrial translational elongation [GO:0070125]; mitochondrial translational termination [GO:0070126]; translation [GO:0006412]


uniprotID: Q9BVS4
geneSymbol: RIOK2
reactome: R-HSA-6791226;
pdb: 5DHF;6G18;6G51;
name: Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)
length: 552
go: ENSG00000058729;
sequence:

opentargets:
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; preribosome, small subunit precursor [GO:0030688]; ATP binding [GO:0005524]; metal ion binding [GO:0046872]; protein kinase activity [GO:0004672]; protein serine/threonine kinase activity [GO:0004674]; cell cycle [GO:0007049]; maturation of SSU-rRNA [GO:0030490]; positive regulation of ribosomal small subunit export from nucleus [GO:2000208]; positive regulation of rRNA processing [GO:2000234]; protein autophosphorylation [GO:0046777]; regulation of mitotic metaphase/anaphase transition [GO:0030071]; ribosomal small subunit biogenesis [GO:0042274]

snps:
rs2544773 rs35165987 rs17849382 rs34916955 rs35713904 rs147608663 rs33996030 rs160632 rs12188395 rs35829000 rs34555783 

isoforms:
ALTERNATIVE PRODUCTS:  Event=Alternative splicing; Named isoforms=2;  Name=1; IsoId=Q9BVS4-1; Sequence=Displayed; Name=2; IsoId=Q9BVS4-2; Sequence=VSP_046388; Note=No experimental confirmation available.; 

location:
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16037817, ECO:0000269|PubMed:19564402}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. {ECO:0000269|PubMed:19564402}.


